NDE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Mutations in this gene cause lissencephaly 4, a disorder characterized by lissencephaly, severe brain atrophy, microcephaly, and severe mental retardation. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.31992618
2positive regulation by symbiont of host defense response (GO:0052509)5.11567465
3modulation by symbiont of host defense response (GO:0052031)5.11567465
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.11567465
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.11567465
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.11567465
7modulation by symbiont of host immune response (GO:0052553)5.11567465
8DNA unwinding involved in DNA replication (GO:0006268)5.08864906
9negative regulation of cell killing (GO:0031342)4.87292770
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.87292770
11protein localization to kinetochore (GO:0034501)4.75581817
12regulation of B cell receptor signaling pathway (GO:0050855)4.69602803
13regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.67846061
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.67845764
15regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.61153323
16mitotic chromosome condensation (GO:0007076)4.55627130
17DNA strand elongation involved in DNA replication (GO:0006271)4.50558115
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.50079621
19antigen processing and presentation of endogenous antigen (GO:0019883)4.45201259
20kinetochore organization (GO:0051383)4.44123177
21sister chromatid segregation (GO:0000819)4.37487550
22antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.36097680
23protein localization to chromosome, centromeric region (GO:0071459)4.36072634
24mitotic sister chromatid segregation (GO:0000070)4.30558355
25DNA strand elongation (GO:0022616)4.29616004
26mitotic metaphase plate congression (GO:0007080)4.28245074
27positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.24569996
28regulation of spindle organization (GO:0090224)4.19328654
29telomere maintenance via semi-conservative replication (GO:0032201)4.10051793
30cellular extravasation (GO:0045123)4.09875102
31negative thymic T cell selection (GO:0045060)4.04630922
32metaphase plate congression (GO:0051310)4.02612160
33CENP-A containing nucleosome assembly (GO:0034080)4.01380773
34regulation of gamma-delta T cell activation (GO:0046643)4.00682060
35regulation of mitotic spindle organization (GO:0060236)3.97207450
36DNA topological change (GO:0006265)3.95675068
37response to interleukin-15 (GO:0070672)3.92688996
38negative T cell selection (GO:0043383)3.90974857
39B cell receptor signaling pathway (GO:0050853)3.86095016
40chromatin remodeling at centromere (GO:0031055)3.82835379
41detection of other organism (GO:0098543)3.82441533
42response to peptidoglycan (GO:0032494)3.82338841
43attachment of spindle microtubules to kinetochore (GO:0008608)3.81693005
44response to muramyl dipeptide (GO:0032495)3.80094676
45mitotic recombination (GO:0006312)3.76342921
46macrophage activation involved in immune response (GO:0002281)3.72093752
47regulation of gamma-delta T cell differentiation (GO:0045586)3.70513173
48* establishment of chromosome localization (GO:0051303)3.70463972
49DNA replication initiation (GO:0006270)3.69916804
50detection of bacterium (GO:0016045)3.69765178
51ribosomal small subunit assembly (GO:0000028)3.68779437
52telomere maintenance via recombination (GO:0000722)3.67016810
53regulation of interferon-beta biosynthetic process (GO:0045357)3.64637393
54DNA replication-dependent nucleosome organization (GO:0034723)3.62319957
55DNA replication-dependent nucleosome assembly (GO:0006335)3.62319957
56DNA replication-independent nucleosome assembly (GO:0006336)3.62305341
57DNA replication-independent nucleosome organization (GO:0034724)3.62305341
58kinetochore assembly (GO:0051382)3.61501901
59mitotic nuclear envelope disassembly (GO:0007077)3.59932182
60leukocyte aggregation (GO:0070486)3.57778168
61positive regulation of chromosome segregation (GO:0051984)3.54611804
62response to host immune response (GO:0052572)3.48548263
63response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.48548263
64cellular response to interleukin-15 (GO:0071350)3.47967495
65spindle checkpoint (GO:0031577)3.44866413
66meiotic chromosome segregation (GO:0045132)3.43664169
67response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.40810527
68response to host (GO:0075136)3.40810527
69response to host defenses (GO:0052200)3.40810527
70positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.35772994
71T cell migration (GO:0072678)3.34432510
72regulation of chromosome segregation (GO:0051983)3.32309537
73DNA ligation (GO:0006266)3.32023681
74positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.31365237
75detection of external biotic stimulus (GO:0098581)3.30963400
76immunoglobulin mediated immune response (GO:0016064)3.30909037
77negative regulation of interleukin-12 production (GO:0032695)3.29862925
78nucleotide-excision repair, DNA gap filling (GO:0006297)3.29820589
79telomere maintenance via telomere lengthening (GO:0010833)3.29118239
80detection of molecule of bacterial origin (GO:0032490)3.28377618
81spindle assembly checkpoint (GO:0071173)3.27851158
82negative regulation of T cell mediated immunity (GO:0002710)3.27822842
83nuclear envelope disassembly (GO:0051081)3.27548460
84membrane disassembly (GO:0030397)3.27548460
85positive regulation of B cell differentiation (GO:0045579)3.24734199
86negative regulation of lymphocyte mediated immunity (GO:0002707)3.23261705
87thymic T cell selection (GO:0045061)3.22893205
88negative regulation of chromosome segregation (GO:0051985)3.22717414
89regulation of B cell differentiation (GO:0045577)3.22476008
90negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.21810102
91negative regulation of sister chromatid segregation (GO:0033046)3.21810102
92negative regulation of mitotic sister chromatid separation (GO:2000816)3.21810102
93negative regulation of mitotic sister chromatid segregation (GO:0033048)3.21810102
94positive regulation of interferon-alpha production (GO:0032727)3.21777201
95mitotic spindle checkpoint (GO:0071174)3.21356424
96response to type I interferon (GO:0034340)3.20816803
97mitotic spindle assembly checkpoint (GO:0007094)3.20472785
98positive thymic T cell selection (GO:0045059)3.20142740
99neutrophil activation involved in immune response (GO:0002283)3.19364343
100cellular response to type I interferon (GO:0071357)3.17230326
101type I interferon signaling pathway (GO:0060337)3.17230326
102histone exchange (GO:0043486)3.15234155
103IMP biosynthetic process (GO:0006188)3.14865950
104positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.13399648
105regulation of mitotic metaphase/anaphase transition (GO:0030071)3.13209674
106chromosome segregation (GO:0007059)3.13076784
107negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.11968293
108microglial cell activation (GO:0001774)3.09954037
109protein localization to chromosome (GO:0034502)3.08329926
110chromosome condensation (GO:0030261)3.08160222
111DNA duplex unwinding (GO:0032508)3.08017604
112regulation of alpha-beta T cell proliferation (GO:0046640)3.07591380
113tolerance induction (GO:0002507)3.06527008
114germinal center formation (GO:0002467)3.06461736
115DNA geometric change (GO:0032392)3.05812773
116regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.05800104
117detection of biotic stimulus (GO:0009595)3.04671036
118IMP metabolic process (GO:0046040)3.04530131
119regulation of exit from mitosis (GO:0007096)3.03103737
120nuclear pore organization (GO:0006999)3.01881900
121histone-serine phosphorylation (GO:0035404)3.01181756
122regulation of sister chromatid cohesion (GO:0007063)2.98932216
123nuclear pore complex assembly (GO:0051292)2.98791352
124regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.97951856
125regulation of interferon-alpha production (GO:0032647)2.96852619
126T cell selection (GO:0045058)2.96085521
127positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.94958207
128positive regulation of granulocyte differentiation (GO:0030854)2.94864853
129B cell mediated immunity (GO:0019724)2.93084133
130regulation of mitotic sister chromatid separation (GO:0010965)2.92567788
131regulation of mitotic sister chromatid segregation (GO:0033047)2.92567788
132regulation of sister chromatid segregation (GO:0033045)2.92567788
133mitotic G2 DNA damage checkpoint (GO:0007095)2.91111149
134negative regulation of erythrocyte differentiation (GO:0045647)2.90713159
135negative regulation of leukocyte mediated immunity (GO:0002704)2.89260972
136DNA replication checkpoint (GO:0000076)2.88938175
137chromatin assembly or disassembly (GO:0006333)2.88686849
138mismatch repair (GO:0006298)2.87652803
139L-serine metabolic process (GO:0006563)2.87522696
140DNA conformation change (GO:0071103)2.84995933
141viral transcription (GO:0019083)2.84992904
142positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.83679315
143positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.83679315
144positive regulation of mitotic sister chromatid separation (GO:1901970)2.83679315
145negative regulation of phagocytosis (GO:0050765)2.82304262
146B cell homeostasis (GO:0001782)2.82049312
147mitotic G2/M transition checkpoint (GO:0044818)2.81962455
148respiratory burst (GO:0045730)2.80873879
149neutrophil activation (GO:0042119)2.80684482
150regulation of centrosome cycle (GO:0046605)2.79287975
151myeloid cell activation involved in immune response (GO:0002275)2.78882670
152ATP-dependent chromatin remodeling (GO:0043044)2.77991616
153translational termination (GO:0006415)2.77364780
154folic acid-containing compound biosynthetic process (GO:0009396)2.76078102
155telomere organization (GO:0032200)2.75032938
156telomere maintenance (GO:0000723)2.74321993
157defense response to protozoan (GO:0042832)2.74291743
158hepatocyte apoptotic process (GO:0097284)2.74240744
159positive T cell selection (GO:0043368)2.73721323
160mitotic sister chromatid cohesion (GO:0007064)2.73691597
161regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.71247182
162formation of translation preinitiation complex (GO:0001731)2.68339423
163interferon-gamma-mediated signaling pathway (GO:0060333)2.67276064
164antigen processing and presentation via MHC class Ib (GO:0002475)2.66568718
165positive regulation of alpha-beta T cell proliferation (GO:0046641)2.66481411
166NIK/NF-kappaB signaling (GO:0038061)2.66183201
167DNA packaging (GO:0006323)2.65355119
168response to protozoan (GO:0001562)2.64903929
169* mitotic cell cycle (GO:0000278)2.64744813
170maturation of SSU-rRNA (GO:0030490)2.64657927
171lymphocyte homeostasis (GO:0002260)2.64515745
172establishment of integrated proviral latency (GO:0075713)2.63708855
173nuclear envelope organization (GO:0006998)2.63688635
174negative regulation of mitosis (GO:0045839)2.63164545
175regulation of mast cell degranulation (GO:0043304)2.63041159
176base-excision repair (GO:0006284)2.62952297
177antigen receptor-mediated signaling pathway (GO:0050851)2.61949845
178negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.61594973
179macrophage activation (GO:0042116)2.61240107
180positive regulation of interleukin-2 production (GO:0032743)2.59840392
181T cell homeostasis (GO:0043029)2.58950015
182regulation of dendritic cell antigen processing and presentation (GO:0002604)2.55668179
183regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.55589174
184lipopolysaccharide-mediated signaling pathway (GO:0031663)2.54588604
185nucleobase biosynthetic process (GO:0046112)2.54510341
186translational elongation (GO:0006414)2.54497305
187negative regulation of innate immune response (GO:0045824)2.54117561
188ribosomal small subunit biogenesis (GO:0042274)2.53919845
189neutrophil mediated immunity (GO:0002446)2.53334244
190negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.53121107
191translesion synthesis (GO:0019985)2.53022592
192positive regulation of humoral immune response (GO:0002922)2.52543434
193granulocyte activation (GO:0036230)2.52209669
194positive regulation of isotype switching (GO:0045830)2.49306599
1953-UTR-mediated mRNA stabilization (GO:0070935)2.48283446
196myeloid dendritic cell activation (GO:0001773)2.46433252
197positive regulation of interferon-beta production (GO:0032728)2.46052348
198regulation of necroptotic process (GO:0060544)2.44738753
199mast cell activation (GO:0045576)2.43777624

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.84196796
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.39581285
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.13785382
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.06347101
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.84575654
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.32340116
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.28345609
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.24991643
9AR_21909140_ChIP-Seq_LNCAP_Human2.62616811
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.48876027
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.45204164
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.36494362
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.36152866
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.32501570
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.32096634
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.29558742
17RUNX_20019798_ChIP-Seq_JUKART_Human2.28830647
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.20469461
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.19673414
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.19370514
21E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.17837887
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.15222786
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.11235128
24TCF7_22412390_ChIP-Seq_EML_Mouse2.09636559
25* XRN2_22483619_ChIP-Seq_HELA_Human2.07195937
26IRF8_27001747_Chip-Seq_BMDM_Mouse2.04690603
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.01065159
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.99685359
29* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.99534637
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.97965812
31BP1_19119308_ChIP-ChIP_Hs578T_Human1.97072558
32FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.96994906
33MAF_26560356_Chip-Seq_TH2_Human1.96918101
34GABP_17652178_ChIP-ChIP_JURKAT_Human1.94988456
35* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.94176160
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.92997795
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.91896104
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.85602676
39ETS1_20019798_ChIP-Seq_JURKAT_Human1.84397937
40KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.84304322
41MYC_22102868_ChIP-Seq_BL_Human1.83970724
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.83916529
43SPI1_23127762_ChIP-Seq_K562_Human1.83592984
44HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.80222937
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.78818044
46KDM2B_26808549_Chip-Seq_SUP-B15_Human1.77565031
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.74606057
48JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.69564127
49E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65858505
50VDR_23849224_ChIP-Seq_CD4+_Human1.65217297
51TP63_17297297_ChIP-ChIP_HaCaT_Human1.64726837
52FOXP3_21729870_ChIP-Seq_TREG_Human1.64106657
53* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.61493674
54* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.61356535
55NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.61317395
56VDR_21846776_ChIP-Seq_THP-1_Human1.59839593
57KDM2B_26808549_Chip-Seq_DND41_Human1.59193055
58* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.58695368
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56470620
60MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.55215966
61CIITA_25753668_ChIP-Seq_RAJI_Human1.53870715
62TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.53098819
63DCP1A_22483619_ChIP-Seq_HELA_Human1.51630776
64* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.46985846
65* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.46331434
66ELK1_19687146_ChIP-ChIP_HELA_Human1.44761908
67TTF2_22483619_ChIP-Seq_HELA_Human1.44369838
68GATA3_27048872_Chip-Seq_THYMUS_Human1.44287971
69MYCN_18555785_ChIP-Seq_MESCs_Mouse1.44142597
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.41219205
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.38462451
72CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.34739244
73GATA1_19941827_ChIP-Seq_MEL_Mouse1.31499863
74ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30570511
75GABP_19822575_ChIP-Seq_HepG2_Human1.29924332
76THAP11_20581084_ChIP-Seq_MESCs_Mouse1.29657628
77GATA2_22383799_ChIP-Seq_G1ME_Mouse1.29645829
78FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.29453289
79NANOG_18555785_ChIP-Seq_MESCs_Mouse1.29137367
80ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28384010
81* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27310147
82* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.24911575
83NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.24730301
84PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24383983
85KDM5A_27292631_Chip-Seq_BREAST_Human1.22432274
86* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21594789
87YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20870489
88TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.20444746
89NCOR1_26117541_ChIP-Seq_K562_Human1.19610074
90KDM2B_26808549_Chip-Seq_JURKAT_Human1.19371654
91* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.18509359
92POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16667013
93MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.16302298
94SPI1_23547873_ChIP-Seq_NB4_Human1.13270317
95HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.12653737
96STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11814647
97* PU_27001747_Chip-Seq_BMDM_Mouse1.10439565
98FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09817514
99PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08682007
100GATA1_19941826_ChIP-Seq_K562_Human1.08552763
101CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07903830
102SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07686650
103TFEB_21752829_ChIP-Seq_HELA_Human1.07244502
104GATA3_26560356_Chip-Seq_TH2_Human1.07071376
105NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06984278
106PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06449576
107Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.04941683
108KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03421807
109* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.02787801
110BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01756736
111MYB_26560356_Chip-Seq_TH2_Human1.01633686
112GATA1_22025678_ChIP-Seq_K562_Human1.00411143
113LXR_22292898_ChIP-Seq_THP-1_Human1.00086444
114KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99358006
115* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98874829
116SRF_21415370_ChIP-Seq_HL-1_Mouse0.98649046
117CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98643298
118CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98452964
119MAF_26560356_Chip-Seq_TH1_Human0.98102956
120SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.96795093
121SCL_19346495_ChIP-Seq_HPC-7_Human0.96732622
122PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96653050
123CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95728749
124PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95434906
125STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95177988
126IRF8_21731497_ChIP-ChIP_J774_Mouse0.94860611
127PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93803818
128LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91965525
129MYB_21317192_ChIP-Seq_ERMYB_Mouse0.91844349
130* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91474240
131VDR_24787735_ChIP-Seq_THP-1_Human0.91025823
132SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90920943
133UTX_26944678_Chip-Seq_JUKART_Human0.90597074
134POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.89948758
135STAT4_19710469_ChIP-ChIP_TH1__Mouse0.88654459
136MYB_26560356_Chip-Seq_TH1_Human0.88457978
137RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88073965
138GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87004792
139VDR_24763502_ChIP-Seq_THP-1_Human0.86889718
140MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.86859682
141CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86728479
142RUNX1_22412390_ChIP-Seq_EML_Mouse0.86704538
143STAT3_1855785_ChIP-Seq_MESCs_Mouse0.86645978
144BCL6_27268052_Chip-Seq_Bcells_Human0.85884753
145CTCF_27219007_Chip-Seq_ERYTHROID_Human0.85469695
146* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.85321836
147CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84552629
148GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84430041
149HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.84315963
150CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83926893
151DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.82801085
152ELK3_25401928_ChIP-Seq_HUVEC_Human0.82515489
153PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.82409287
154* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.80957632
155* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.80837202
156ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.80105315
157* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.79261306

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.75577017
2MP0003111_abnormal_nucleus_morphology3.48390490
3MP0003077_abnormal_cell_cycle3.42673760
4MP0003693_abnormal_embryo_hatching3.29437469
5MP0003303_peritoneal_inflammation3.16582001
6MP0004957_abnormal_blastocyst_morpholog3.03581037
7MP0008007_abnormal_cellular_replicative2.94241074
8MP0008057_abnormal_DNA_replication2.78822707
9MP0001790_abnormal_immune_system2.72966327
10MP0005387_immune_system_phenotype2.72966327
11MP0002396_abnormal_hematopoietic_system2.46959902
12MP0003724_increased_susceptibility_to2.42636934
13MP0006054_spinal_hemorrhage2.22488824
14MP0010030_abnormal_orbit_morphology2.21558328
15MP0004381_abnormal_hair_follicle2.18261114
16MP0008932_abnormal_embryonic_tissue2.02005359
17MP0002148_abnormal_hypersensitivity_rea1.98315104
18MP0004947_skin_inflammation1.91824259
19MP0001730_embryonic_growth_arrest1.88155033
20MP0008058_abnormal_DNA_repair1.84671781
21MP0005451_abnormal_body_composition1.83330127
22MP0010352_gastrointestinal_tract_polyps1.82569585
23MP0005464_abnormal_platelet_physiology1.81008963
24MP0000350_abnormal_cell_proliferation1.76707497
25MP0010307_abnormal_tumor_latency1.74950452
26MP0008438_abnormal_cutaneous_collagen1.74910256
27MP0003300_gastrointestinal_ulcer1.73982536
28MP0008260_abnormal_autophagy1.69002165
29MP0003705_abnormal_hypodermis_morpholog1.58089552
30MP0001533_abnormal_skeleton_physiology1.53215252
31MP0003763_abnormal_thymus_physiology1.50972062
32MP0004808_abnormal_hematopoietic_stem1.47857104
33MP0009333_abnormal_splenocyte_physiolog1.46407692
34MP0003183_abnormal_peptide_metabolism1.45645565
35MP0001845_abnormal_inflammatory_respons1.43891900
36MP0005380_embryogenesis_phenotype1.43687018
37MP0001672_abnormal_embryogenesis/_devel1.43687018
38MP0001697_abnormal_embryo_size1.43266323
39MP0003191_abnormal_cellular_cholesterol1.42205126
40MP0002006_tumorigenesis1.40137475
41MP0003950_abnormal_plasma_membrane1.36124804
42MP0003984_embryonic_growth_retardation1.34135655
43MP0003279_aneurysm1.33164807
44MP0000685_abnormal_immune_system1.31495695
45MP0002019_abnormal_tumor_incidence1.30124106
46MP0002088_abnormal_embryonic_growth/wei1.29987694
47MP0002398_abnormal_bone_marrow1.29538759
48MP0005310_abnormal_salivary_gland1.28679615
49MP0006082_CNS_inflammation1.26724759
50MP0005076_abnormal_cell_differentiation1.26566261
51MP0002080_prenatal_lethality1.26476749
52MP0001851_eye_inflammation1.25883281
53MP0000015_abnormal_ear_pigmentation1.25678941
54MP0002085_abnormal_embryonic_tissue1.25547982
55MP0003123_paternal_imprinting1.24703464
56MP0000733_abnormal_muscle_development1.24376702
57MP0000490_abnormal_crypts_of1.23058635
58MP0005023_abnormal_wound_healing1.22943594
59MP0009053_abnormal_anal_canal1.21514738
60MP0001835_abnormal_antigen_presentation1.21407813
61MP0000313_abnormal_cell_death1.20266493
62MP0004197_abnormal_fetal_growth/weight/1.20049129
63MP0001293_anophthalmia1.19601994
64MP0002086_abnormal_extraembryonic_tissu1.17676605
65MP0003866_abnormal_defecation1.16151595
66MP0001915_intracranial_hemorrhage1.15653951
67MP0003172_abnormal_lysosome_physiology1.15451250
68MP0000703_abnormal_thymus_morphology1.14611945
69MP0000689_abnormal_spleen_morphology1.13992797
70MP0001873_stomach_inflammation1.12791878
71MP0002722_abnormal_immune_system1.11702062
72MP0002084_abnormal_developmental_patter1.10678383
73MP0003567_abnormal_fetal_cardiomyocyte1.09180345
74MP0008961_abnormal_basal_metabolism1.08089975
75MP0002009_preneoplasia1.07465806
76MP0003566_abnormal_cell_adhesion1.06666687
77MP0004883_abnormal_blood_vessel1.05796503
78MP0001800_abnormal_humoral_immune1.04040947
79MP0003828_pulmonary_edema1.03967141
80MP0002429_abnormal_blood_cell1.03680357
81MP0003937_abnormal_limbs/digits/tail_de1.03489061
82MP0003045_fibrosis1.03262608
83MP0008469_abnormal_protein_level1.03161133
84MP0000858_altered_metastatic_potential1.02978152
85MP0005075_abnormal_melanosome_morpholog1.01182554
86MP0003453_abnormal_keratinocyte_physiol1.00947010
87MP0000465_gastrointestinal_hemorrhage0.99793268
88MP0002998_abnormal_bone_remodeling0.99335065
89MP0000716_abnormal_immune_system0.98616304
90MP0002452_abnormal_antigen_presenting0.97601962
91MP0005397_hematopoietic_system_phenotyp0.96249151
92MP0001545_abnormal_hematopoietic_system0.96249151
93MP0002420_abnormal_adaptive_immunity0.96050936
94MP0001853_heart_inflammation0.94337802
95MP0001819_abnormal_immune_cell0.93357559
96MP0002132_abnormal_respiratory_system0.91253636
97MP0003806_abnormal_nucleotide_metabolis0.90424065
98MP0000537_abnormal_urethra_morphology0.90032318
99MP0001243_abnormal_dermal_layer0.89675991
100MP0000569_abnormal_digit_pigmentation0.89246447
101MP0002092_abnormal_eye_morphology0.89085313
102MP0001879_abnormal_lymphatic_vessel0.88787825
103MP0005671_abnormal_response_to0.86635519
104MP0005164_abnormal_response_to0.86106242
105MP0005623_abnormal_meninges_morphology0.85875739
106MP0009278_abnormal_bone_marrow0.85102516
107MP0009764_decreased_sensitivity_to0.84467696
108MP0000566_synostosis0.83818888
109MP0003115_abnormal_respiratory_system0.83640009
110MP0003091_abnormal_cell_migration0.83520995
111MP0002405_respiratory_system_inflammati0.83076776
112MP0003121_genomic_imprinting0.83037712
113MP0003656_abnormal_erythrocyte_physiolo0.82565352
114MP0002166_altered_tumor_susceptibility0.82384785
115MP0004134_abnormal_chest_morphology0.82378318
116MP0000428_abnormal_craniofacial_morphol0.82044039
117MP0005083_abnormal_biliary_tract0.81164205
118MP0003786_premature_aging0.81154508
119MP0003448_altered_tumor_morphology0.80909574
120MP0002111_abnormal_tail_morphology0.80736697
121MP0000767_abnormal_smooth_muscle0.79743580
122MP0002925_abnormal_cardiovascular_devel0.79105805
123MP0005621_abnormal_cell_physiology0.78732120
124MP0002723_abnormal_immune_serum0.78410852
125MP0002932_abnormal_joint_morphology0.76657723
126MP0002877_abnormal_melanocyte_morpholog0.75848206
127MP0003186_abnormal_redox_activity0.74778299
128MP0001849_ear_inflammation0.74683664
129MP0009785_altered_susceptibility_to0.74351506
130MP0005025_abnormal_response_to0.72777747
131MP0002933_joint_inflammation0.72181431
132MP0010368_abnormal_lymphatic_system0.70323713
133MP0005000_abnormal_immune_tolerance0.70297645
134MP0002128_abnormal_blood_circulation0.69915386
135MP0000371_diluted_coat_color0.69340070
136MP0004272_abnormal_basement_membrane0.68975591
137MP0009931_abnormal_skin_appearance0.68479410
138MP0003943_abnormal_hepatobiliary_system0.67938182
139MP0003436_decreased_susceptibility_to0.67686714
140MP0003221_abnormal_cardiomyocyte_apopto0.67675627
141MP0009763_increased_sensitivity_to0.67235513
142MP0010155_abnormal_intestine_physiology0.66903256
143MP0002419_abnormal_innate_immunity0.66037816
144MP0005409_darkened_coat_color0.65516586
145MP0001348_abnormal_lacrimal_gland0.65507132
146MP0009115_abnormal_fat_cell0.64315394
147MP0001216_abnormal_epidermal_layer0.62320614
148MP0005390_skeleton_phenotype0.58892578

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.83171210
2Recurrent bacterial skin infections (HP:0005406)4.71693876
3Myositis (HP:0100614)4.43896930
4Recurrent abscess formation (HP:0002722)4.31793926
5Abnormal delayed hypersensitivity skin test (HP:0002963)4.17488946
6Orchitis (HP:0100796)3.98649023
7Recurrent fungal infections (HP:0002841)3.84647341
8Retrobulbar optic neuritis (HP:0100654)3.79400465
9Optic neuritis (HP:0100653)3.79400465
10Mediastinal lymphadenopathy (HP:0100721)3.66679063
11Meningitis (HP:0001287)3.65903581
12Abnormality of macrophages (HP:0004311)3.65855953
13Vasculitis (HP:0002633)3.53678247
14Stomatitis (HP:0010280)3.48098259
15Increased IgE level (HP:0003212)3.44414428
16Gastrointestinal infarctions (HP:0005244)3.42071121
17Reticulocytopenia (HP:0001896)3.35874006
18Recurrent skin infections (HP:0001581)3.33640940
19Panhypogammaglobulinemia (HP:0003139)3.32384816
20Recurrent cutaneous fungal infections (HP:0011370)3.31675422
21Chronic mucocutaneous candidiasis (HP:0002728)3.31675422
22Abnormal lung lobation (HP:0002101)3.21190180
23Encephalitis (HP:0002383)3.19026954
24Pustule (HP:0200039)3.07497706
25Spontaneous hematomas (HP:0007420)3.04948687
26Colon cancer (HP:0003003)3.00433418
27Viral hepatitis (HP:0006562)2.99365842
28Selective tooth agenesis (HP:0001592)2.98346650
29Keratoconjunctivitis sicca (HP:0001097)2.98088307
30Agammaglobulinemia (HP:0004432)2.97016996
31Chromsome breakage (HP:0040012)2.94870390
32Short 4th metacarpal (HP:0010044)2.91832565
33Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.91832565
34Gastrointestinal inflammation (HP:0004386)2.90095014
35Inflammation of the large intestine (HP:0002037)2.90073661
36Urticaria (HP:0001025)2.90050289
37Increased nuchal translucency (HP:0010880)2.88109711
38Obstructive lung disease (HP:0006536)2.86870212
39Chronic obstructive pulmonary disease (HP:0006510)2.86870212
40Hypochromic anemia (HP:0001931)2.86559170
41Colitis (HP:0002583)2.82651839
42Abnormality of T cell number (HP:0011839)2.80739287
43Abnormality of T cells (HP:0002843)2.79838378
44Gastrointestinal stroma tumor (HP:0100723)2.78799523
45Chest pain (HP:0100749)2.76254941
46Recurrent gram-negative bacterial infections (HP:0005420)2.75758009
47Pulmonary infiltrates (HP:0002113)2.74718775
48Prolonged bleeding time (HP:0003010)2.72579547
49Lymphopenia (HP:0001888)2.71696473
50Abnormality of T cell physiology (HP:0011840)2.70122748
51Keratoconjunctivitis (HP:0001096)2.69326128
52Abnormality of cells of the lymphoid lineage (HP:0012140)2.67169393
53Chromosomal breakage induced by crosslinking agents (HP:0003221)2.65678529
54Abnormality of the fingertips (HP:0001211)2.64061976
55Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.63273236
56Duplicated collecting system (HP:0000081)2.60889569
57Arterial thrombosis (HP:0004420)2.56837415
58Abnormality of the calcaneus (HP:0008364)2.53712075
59Osteomyelitis (HP:0002754)2.49051776
60Gingivitis (HP:0000230)2.48160553
61Granulocytopenia (HP:0001913)2.43099318
62Hypochromic microcytic anemia (HP:0004840)2.42349653
63Subacute progressive viral hepatitis (HP:0006572)2.41672775
64Medulloblastoma (HP:0002885)2.39892552
65Verrucae (HP:0200043)2.37291734
66Papilloma (HP:0012740)2.37291734
67Breast hypoplasia (HP:0003187)2.36650565
68Recurrent bronchitis (HP:0002837)2.35969293
69Thrombocytosis (HP:0001894)2.35646706
7011 pairs of ribs (HP:0000878)2.33839998
71Epistaxis (HP:0000421)2.32988839
72Abnormality of the renal collecting system (HP:0004742)2.32220792
73Nephroblastoma (Wilms tumor) (HP:0002667)2.32127613
74Ectopic kidney (HP:0000086)2.31790015
75Small intestinal stenosis (HP:0012848)2.31362704
76Duodenal stenosis (HP:0100867)2.31362704
77Embryonal renal neoplasm (HP:0011794)2.28308226
78Acute hepatic failure (HP:0006554)2.27597436
79Autoimmune hemolytic anemia (HP:0001890)2.26996000
80Deviation of the thumb (HP:0009603)2.25855164
81Recurrent sinusitis (HP:0011108)2.25434355
82Gingival bleeding (HP:0000225)2.24784165
83Leukocytosis (HP:0001974)2.23864130
84Sepsis (HP:0100806)2.21932908
85Increased IgM level (HP:0003496)2.21746791
86Mesangial abnormality (HP:0001966)2.21533761
87Protrusio acetabuli (HP:0003179)2.21491974
88Spinal cord lesions (HP:0100561)2.21344521
89Syringomyelia (HP:0003396)2.21344521
90Skin ulcer (HP:0200042)2.19706461
91Birth length less than 3rd percentile (HP:0003561)2.19479006
92Myelodysplasia (HP:0002863)2.18968913
93Aplasia/Hypoplasia of the sacrum (HP:0008517)2.16854740
94Patellar aplasia (HP:0006443)2.16546978
95Proximal placement of thumb (HP:0009623)2.16244714
96Abnormality of cells of the erythroid lineage (HP:0012130)2.16066461
97Ependymoma (HP:0002888)2.15549918
98Calcaneovalgus deformity (HP:0001848)2.15199828
99High pitched voice (HP:0001620)2.13985051
100Missing ribs (HP:0000921)2.13519971
101Abnormality of chromosome stability (HP:0003220)2.13181312
102IgA deficiency (HP:0002720)2.13117423
103Meckel diverticulum (HP:0002245)2.11663543
104Abnormal number of incisors (HP:0011064)2.11314991
105Abnormal number of erythroid precursors (HP:0012131)2.10725017
106Gangrene (HP:0100758)2.10608641
107Episodic fever (HP:0001954)2.08665122
108Abnormality of the peritoneum (HP:0002585)2.06465665
109Hemoptysis (HP:0002105)2.06018489
110Fatigue (HP:0012378)2.05480515
111Chronic otitis media (HP:0000389)2.05168590
112Agnosia (HP:0010524)2.04290071
113Abnormality of the 4th metacarpal (HP:0010012)2.03719789
114Abnormality of the ileum (HP:0001549)2.02354562
115Abnormality of the pleura (HP:0002103)2.02310428
116Anorexia (HP:0002039)2.00286155
117Cutaneous melanoma (HP:0012056)1.99212841
118IgG deficiency (HP:0004315)1.98643521
119Aplasia/Hypoplasia of the patella (HP:0006498)1.97856142
120Slow saccadic eye movements (HP:0000514)1.96990503
121Volvulus (HP:0002580)1.96588219
122Rhabdomyosarcoma (HP:0002859)1.92996126
123Lymphoma (HP:0002665)1.91812717
124Glomerulopathy (HP:0100820)1.91715770
125Neoplasm of the pancreas (HP:0002894)1.91277363
126Deformed tarsal bones (HP:0008119)1.90280980
127Abnormality of chromosome segregation (HP:0002916)1.88705519
128Eosinophilia (HP:0001880)1.88469581
129Chronic diarrhea (HP:0002028)1.87647084
130Peritonitis (HP:0002586)1.86674412
131Abnormality of the duodenum (HP:0002246)1.86601136
132Emphysema (HP:0002097)1.86426455
133Hypoplasia of the capital femoral epiphysis (HP:0003090)1.86134842
134Soft skin (HP:0000977)1.86121927
135Abnormality of nail color (HP:0100643)1.86059636
136Abnormal platelet volume (HP:0011876)1.85836964
137Broad distal phalanx of finger (HP:0009836)1.85830190
138Increased mean platelet volume (HP:0011877)1.85151125
139Absent radius (HP:0003974)1.85021289
140Elevated erythrocyte sedimentation rate (HP:0003565)1.84936279
141Trigonocephaly (HP:0000243)1.84206782
142Skin rash (HP:0000988)1.82778334
143Ankle contracture (HP:0006466)1.82534787
144Leukopenia (HP:0001882)1.82534388
145* Sloping forehead (HP:0000340)1.82065625
146Ovarian neoplasm (HP:0100615)1.81360053
147Hypergammaglobulinemia (HP:0010702)1.81283175
148Cellulitis (HP:0100658)1.80119996
149* Aplasia/Hypoplasia of the thymus (HP:0010515)1.79619799
150Cafe-au-lait spot (HP:0000957)1.79322672
151Hypoplastic pelvis (HP:0008839)1.78970810
152Microcytic anemia (HP:0001935)1.78162699
153Short middle phalanx of the 5th finger (HP:0004220)1.77603180
154Basal cell carcinoma (HP:0002671)1.77151002
155Arthralgia (HP:0002829)1.76926132
156Atresia of the external auditory canal (HP:0000413)1.76756003
157Premature graying of hair (HP:0002216)1.76596012
158Segmental peripheral demyelination/remyelination (HP:0003481)1.76147200
159Neoplasm of the colon (HP:0100273)1.74721348
160Recurrent viral infections (HP:0004429)1.74073798
161Amaurosis fugax (HP:0100576)1.73964749
162Recurrent lower respiratory tract infections (HP:0002783)1.73854892
163Abnormality of the astrocytes (HP:0100707)1.73686435
164Astrocytoma (HP:0009592)1.73686435
165Cheilitis (HP:0100825)1.73521101
166Aplasia/Hypoplasia of the uvula (HP:0010293)1.73466187
167Aplastic anemia (HP:0001915)1.73216714
168Nonimmune hydrops fetalis (HP:0001790)1.71780103
169T lymphocytopenia (HP:0005403)1.71485128
170Oral leukoplakia (HP:0002745)1.71213289
171Cerebral hypomyelination (HP:0006808)1.70805313
172Prominent nose (HP:0000448)1.70721711
173Flared metaphyses (HP:0003015)1.70524644
174Bicuspid aortic valve (HP:0001647)1.70294327
175Biconcave vertebral bodies (HP:0004586)1.70225924
176Petechiae (HP:0000967)1.70209335
177Ascites (HP:0001541)1.69306977
178Skull defect (HP:0001362)1.68984287
179IgM deficiency (HP:0002850)1.67065092
180Absent forearm bone (HP:0003953)1.66339214
181Aplasia involving forearm bones (HP:0009822)1.66339214
182Carpal bone hypoplasia (HP:0001498)1.66114428
183Asplenia (HP:0001746)1.64165726
184Bone marrow hypocellularity (HP:0005528)1.64030161
185Renal duplication (HP:0000075)1.63844941
186Multiple enchondromatosis (HP:0005701)1.63377148
187Asymmetry of the thorax (HP:0001555)1.63202708
188Abnormal umbilical cord blood vessels (HP:0011403)1.63083257
189Single umbilical artery (HP:0001195)1.63083257
190Abnormality of the fetal cardiovascular system (HP:0010948)1.63083257

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.93017985
2RIPK43.83941481
3CDC73.63415540
4WEE12.96880033
5SMG12.71050471
6IRAK42.63769962
7STK102.40825977
8BRSK22.40503577
9NEK22.36947292
10TESK22.16315932
11EIF2AK12.03824557
12TTK2.02000346
13BLK1.79698085
14PBK1.77646499
15CSK1.77390669
16GRK61.76021931
17TAOK21.72535100
18MAP3K131.71707364
19MKNK11.70109970
20CLK11.69805320
21MAP3K101.69687931
22STK41.65183488
23MAP4K11.64032138
24AURKB1.61612536
25EEF2K1.59302464
26TGFBR11.57563217
27BRSK11.57059471
28PLK11.55738007
29TLK11.53568014
30SRPK11.49607824
31LRRK21.48735275
32MAP3K81.47437158
33PLK41.47076968
34IKBKE1.46939116
35FGFR41.41320084
36SYK1.40771496
37PASK1.39196509
38RPS6KA41.37194560
39RPS6KB21.35962154
40PKN21.35691414
41CDK121.32448814
42NME21.32082326
43FES1.31466682
44CDK71.29938484
45PAK41.29836645
46MAP3K31.29715662
47SIK31.28153810
48SIK21.28012156
49HCK1.26269123
50ATR1.25197499
51CDK41.24820379
52TAOK31.24275596
53TXK1.23554141
54NEK11.21855223
55IKBKB1.21450337
56FGR1.18911740
57MAP3K111.18751230
58MELK1.18680990
59FLT31.18581441
60TSSK61.17693266
61NEK91.17525753
62TTN1.16393102
63PLK31.15598748
64LATS11.15593287
65JAK11.15215692
66SCYL21.15094171
67TAOK11.14968470
68TNK21.12220838
69SIK11.09053102
70CHEK21.08609110
71IRAK31.05481111
72PRPF4B1.02598533
73CDK61.02025327
74VRK11.01468718
75FGFR31.01277863
76CDC42BPA0.99124901
77TRIB30.97814714
78MST40.97730331
79LYN0.96696726
80MARK20.94530503
81AURKA0.94030954
82MAP3K10.93372511
83CHEK10.90269886
84MAP2K30.89807181
85KDR0.84907515
86CSF1R0.84502851
87EPHB10.84148609
88TAF10.83684362
89CDK80.83617297
90BTK0.83308428
91WNK10.82676618
92IRAK10.82407474
93BMPR20.79242705
94KIT0.78862866
95JAK20.78766682
96MAPK110.77583329
97STK30.77437904
98ACVR1B0.72982475
99CCNB10.72114366
100CAMK1D0.71874693
101TYK20.69469385
102HIPK20.68588203
103MAP3K70.67805319
104JAK30.67408135
105KSR20.67178503
106ATM0.66315438
107NUAK10.65665045
108PAK10.65105429
109MAPKAPK20.64881605
110EIF2AK30.64328568
111ILK0.63294133
112UHMK10.62028251
113BRD40.61267204
114PIM10.61225848
115TGFBR20.59915745
116ITK0.58938389
117MATK0.58103980
118ERN10.57203555
119MARK30.56546899
120PDK10.55552625
121* CDK20.55240119
122PRKD20.53792420
123DYRK30.53753068
124MKNK20.52520241
125RPS6KA50.51756367
126* CDK10.51446472
127TRPM70.49522260
128CDK90.48906730
129PAK20.48558739
130PRKCQ0.48479893
131EIF2AK20.48472154
132ZAK0.47590533
133TESK10.47024585
134IRAK20.46394857
135ICK0.46274851
136VRK20.45607844
137PTK60.45541190
138ZAP700.44462057
139MAP3K140.43689198
140NLK0.43640304
141LIMK10.42985087
142LCK0.40351274
143FGFR10.39572833
144MAPK70.39426067
145PDPK10.38930219
146MTOR0.37847382
147CSNK2A10.37650717
148PIK3CG0.36132207
149CHUK0.35861985
150ROCK20.35008798
151TEC0.34933892
152TBK10.34746428
153YES10.33879379
154RPS6KL10.28364058
155RPS6KC10.28364058
156SGK30.27020540

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.78034720
2Mismatch repair_Homo sapiens_hsa034303.88969861
3Base excision repair_Homo sapiens_hsa034103.27495301
4Cell cycle_Homo sapiens_hsa041102.90111162
5Spliceosome_Homo sapiens_hsa030402.75724443
6Homologous recombination_Homo sapiens_hsa034402.71411119
7Nucleotide excision repair_Homo sapiens_hsa034202.54659903
8One carbon pool by folate_Homo sapiens_hsa006702.37776650
9Ribosome_Homo sapiens_hsa030102.36153845
10Osteoclast differentiation_Homo sapiens_hsa043802.26848009
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.24450699
12RNA transport_Homo sapiens_hsa030132.21875816
13Graft-versus-host disease_Homo sapiens_hsa053322.19394701
14Non-homologous end-joining_Homo sapiens_hsa034502.09672632
15Proteasome_Homo sapiens_hsa030501.89176605
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.88469241
17Autoimmune thyroid disease_Homo sapiens_hsa053201.87170782
18RNA polymerase_Homo sapiens_hsa030201.78995700
19Fanconi anemia pathway_Homo sapiens_hsa034601.74853622
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.68848680
21p53 signaling pathway_Homo sapiens_hsa041151.62661521
22Pyrimidine metabolism_Homo sapiens_hsa002401.59885974
23Tuberculosis_Homo sapiens_hsa051521.58257308
24Staphylococcus aureus infection_Homo sapiens_hsa051501.58091682
25RNA degradation_Homo sapiens_hsa030181.47339820
26Systemic lupus erythematosus_Homo sapiens_hsa053221.40587077
27TNF signaling pathway_Homo sapiens_hsa046681.37654407
28mRNA surveillance pathway_Homo sapiens_hsa030151.37343693
29Type I diabetes mellitus_Homo sapiens_hsa049401.33085855
30Primary immunodeficiency_Homo sapiens_hsa053401.31550266
31Basal transcription factors_Homo sapiens_hsa030221.29155205
32Viral carcinogenesis_Homo sapiens_hsa052031.28385798
33Chemokine signaling pathway_Homo sapiens_hsa040621.24166674
34Small cell lung cancer_Homo sapiens_hsa052221.16612812
35Herpes simplex infection_Homo sapiens_hsa051681.16457602
36Epstein-Barr virus infection_Homo sapiens_hsa051691.16407655
37Renal cell carcinoma_Homo sapiens_hsa052111.15086901
38Antigen processing and presentation_Homo sapiens_hsa046121.14439475
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.13881108
40MicroRNAs in cancer_Homo sapiens_hsa052061.08128707
41HTLV-I infection_Homo sapiens_hsa051661.07520036
42Endometrial cancer_Homo sapiens_hsa052131.05435804
43Hepatitis C_Homo sapiens_hsa051601.04940691
44VEGF signaling pathway_Homo sapiens_hsa043701.04828755
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.04212369
46Asthma_Homo sapiens_hsa053101.01960245
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98056901
48Neurotrophin signaling pathway_Homo sapiens_hsa047220.97611437
49Viral myocarditis_Homo sapiens_hsa054160.97511736
50Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.96625792
51Measles_Homo sapiens_hsa051620.92933479
52Chronic myeloid leukemia_Homo sapiens_hsa052200.92579956
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.92014369
54African trypanosomiasis_Homo sapiens_hsa051430.91869060
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91862618
56Prolactin signaling pathway_Homo sapiens_hsa049170.91181487
57Shigellosis_Homo sapiens_hsa051310.88885293
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.88200133
59Legionellosis_Homo sapiens_hsa051340.87905750
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85637638
61FoxO signaling pathway_Homo sapiens_hsa040680.85388612
62Apoptosis_Homo sapiens_hsa042100.83358932
63Vitamin B6 metabolism_Homo sapiens_hsa007500.81877333
64Notch signaling pathway_Homo sapiens_hsa043300.76292308
65Leukocyte transendothelial migration_Homo sapiens_hsa046700.75960233
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74159899
67Basal cell carcinoma_Homo sapiens_hsa052170.74096471
68B cell receptor signaling pathway_Homo sapiens_hsa046620.74039549
69HIF-1 signaling pathway_Homo sapiens_hsa040660.73350674
70Hepatitis B_Homo sapiens_hsa051610.71347474
71Oocyte meiosis_Homo sapiens_hsa041140.70774604
72ErbB signaling pathway_Homo sapiens_hsa040120.70494593
73Inositol phosphate metabolism_Homo sapiens_hsa005620.70447379
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70336457
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69382334
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.68136023
77Biosynthesis of amino acids_Homo sapiens_hsa012300.68007593
78Purine metabolism_Homo sapiens_hsa002300.67848465
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67733196
80Leishmaniasis_Homo sapiens_hsa051400.67296360
81Dorso-ventral axis formation_Homo sapiens_hsa043200.67067535
82mTOR signaling pathway_Homo sapiens_hsa041500.64352233
83Hippo signaling pathway_Homo sapiens_hsa043900.63387762
84Hematopoietic cell lineage_Homo sapiens_hsa046400.62472626
85Malaria_Homo sapiens_hsa051440.62210100
86Pancreatic cancer_Homo sapiens_hsa052120.61741564
87Steroid biosynthesis_Homo sapiens_hsa001000.61460064
88TGF-beta signaling pathway_Homo sapiens_hsa043500.61006558
89Glioma_Homo sapiens_hsa052140.60739255
90Phagosome_Homo sapiens_hsa041450.59523592
91Pentose phosphate pathway_Homo sapiens_hsa000300.58650500
92Choline metabolism in cancer_Homo sapiens_hsa052310.57663747
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56705869
94Protein export_Homo sapiens_hsa030600.56637148
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55846224
96Endocytosis_Homo sapiens_hsa041440.54143446
97ECM-receptor interaction_Homo sapiens_hsa045120.53875720
98Other glycan degradation_Homo sapiens_hsa005110.53460538
99Adherens junction_Homo sapiens_hsa045200.53039363
100MAPK signaling pathway_Homo sapiens_hsa040100.53008203
101Toxoplasmosis_Homo sapiens_hsa051450.52838322
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.52643645
103Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52172229
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51057684
105Colorectal cancer_Homo sapiens_hsa052100.50980713
106Pathways in cancer_Homo sapiens_hsa052000.50263834
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49458389
108Influenza A_Homo sapiens_hsa051640.49252367
109Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48591585
110Glutathione metabolism_Homo sapiens_hsa004800.48320331
111NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48287711
112Prostate cancer_Homo sapiens_hsa052150.48202876
113Salmonella infection_Homo sapiens_hsa051320.47308639
114Pertussis_Homo sapiens_hsa051330.46619314
115Intestinal immune network for IgA production_Homo sapiens_hsa046720.46285067
116Thyroid cancer_Homo sapiens_hsa052160.46218900
117Allograft rejection_Homo sapiens_hsa053300.46207058
118Proteoglycans in cancer_Homo sapiens_hsa052050.45405089
119Bladder cancer_Homo sapiens_hsa052190.45326725
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45265012
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.44233405
122Non-small cell lung cancer_Homo sapiens_hsa052230.42782071
123T cell receptor signaling pathway_Homo sapiens_hsa046600.42726234
124Cysteine and methionine metabolism_Homo sapiens_hsa002700.42104046
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.41933636
126Acute myeloid leukemia_Homo sapiens_hsa052210.41518947
127Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.41065205
128Selenocompound metabolism_Homo sapiens_hsa004500.40986838
129Insulin resistance_Homo sapiens_hsa049310.40706208
130Focal adhesion_Homo sapiens_hsa045100.40473348
131PI3K-Akt signaling pathway_Homo sapiens_hsa041510.40289397
132Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39750231
133Fatty acid elongation_Homo sapiens_hsa000620.39539337
134GnRH signaling pathway_Homo sapiens_hsa049120.39391765
135Carbon metabolism_Homo sapiens_hsa012000.37091542
136Platelet activation_Homo sapiens_hsa046110.36664989
137Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33856480
138AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.33547061
139Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33345413
140Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33099491
141Jak-STAT signaling pathway_Homo sapiens_hsa046300.32573307
142RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.31756621
143Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31235408

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »