NCR3LG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: B7H6 belongs to the B7 family (see MIM 605402) and is selectively expressed on tumor cells. Interaction of B7H6 with NKp30 (NCR3; MIM 611550) results in natural killer (NK) cell activation and cytotoxicity (Brandt et al., 2009 [PubMed 19528259]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)9.75377133
2nuclear pore organization (GO:0006999)8.75442776
3pore complex assembly (GO:0046931)7.51241796
4DNA unwinding involved in DNA replication (GO:0006268)5.75428180
5regulation of translational fidelity (GO:0006450)4.91644184
6chromosome condensation (GO:0030261)4.53020069
7regulation of RNA export from nucleus (GO:0046831)4.46208931
8DNA packaging (GO:0006323)4.43919667
9mitotic chromosome condensation (GO:0007076)4.34491951
10regulation of vitamin D biosynthetic process (GO:0060556)4.34137113
11mitotic nuclear envelope disassembly (GO:0007077)4.17791889
12DNA replication initiation (GO:0006270)4.15735571
13folic acid-containing compound biosynthetic process (GO:0009396)4.13089862
14mitotic sister chromatid cohesion (GO:0007064)4.12304077
15sister chromatid segregation (GO:0000819)4.09674987
16nuclear envelope disassembly (GO:0051081)4.07657828
17membrane disassembly (GO:0030397)4.07657828
18mitotic sister chromatid segregation (GO:0000070)3.90870949
19regulation of NFAT protein import into nucleus (GO:0051532)3.90318875
20regulation of histone H3-K27 methylation (GO:0061085)3.83721236
21regulation of nucleobase-containing compound transport (GO:0032239)3.82261251
22DNA conformation change (GO:0071103)3.79015372
23regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.77559928
24DNA synthesis involved in DNA repair (GO:0000731)3.74637824
25DNA strand elongation involved in DNA replication (GO:0006271)3.73679107
26DNA duplex unwinding (GO:0032508)3.71623070
27positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.68083880
28proline biosynthetic process (GO:0006561)3.64863669
29DNA strand elongation (GO:0022616)3.62799699
30COPII vesicle coating (GO:0048208)3.61970013
31dosage compensation (GO:0007549)3.60517715
32regulation of vitamin metabolic process (GO:0030656)3.56260866
33COPI coating of Golgi vesicle (GO:0048205)3.54187429
34Golgi transport vesicle coating (GO:0048200)3.54187429
35DNA geometric change (GO:0032392)3.53743035
36DNA topological change (GO:0006265)3.49122182
37cellular protein complex localization (GO:0034629)3.45454616
38oligosaccharide catabolic process (GO:0009313)3.40698727
39very-low-density lipoprotein particle assembly (GO:0034379)3.34698762
40tetrahydrofolate metabolic process (GO:0046653)3.34271495
41positive regulation of cell cycle checkpoint (GO:1901978)3.29484590
42regulation of sister chromatid cohesion (GO:0007063)3.27098788
43negative regulation of histone methylation (GO:0031061)3.27041787
44spliceosomal tri-snRNP complex assembly (GO:0000244)3.25208342
45regulation of DNA damage checkpoint (GO:2000001)3.11828474
46nuclear envelope organization (GO:0006998)3.10368101
47regulation of centriole replication (GO:0046599)3.10237171
48plasma lipoprotein particle assembly (GO:0034377)3.05175984
49protein localization to chromosome, centromeric region (GO:0071459)3.05031409
50telomere maintenance via semi-conservative replication (GO:0032201)3.01226088
51mRNA transport (GO:0051028)2.97967835
52regulation of translational elongation (GO:0006448)2.96821456
53protein-lipid complex assembly (GO:0065005)2.95003469
54DNA replication checkpoint (GO:0000076)2.94063362
55response to lipoprotein particle (GO:0055094)2.88433063
56IMP biosynthetic process (GO:0006188)2.87222427
57positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.87037354
58nucleus organization (GO:0006997)2.82995564
59telomere maintenance via recombination (GO:0000722)2.82621183
60regulation of cholesterol homeostasis (GO:2000188)2.82060579
61regulation of histone H3-K4 methylation (GO:0051569)2.80781171
62low-density lipoprotein particle clearance (GO:0034383)2.79627766
63meiotic chromosome segregation (GO:0045132)2.75929615
64glucocorticoid receptor signaling pathway (GO:0042921)2.75425284
65folic acid-containing compound metabolic process (GO:0006760)2.73658334
66mitochondrial DNA metabolic process (GO:0032042)2.72003223
67vesicle coating (GO:0006901)2.70952161
68non-recombinational repair (GO:0000726)2.69774290
69double-strand break repair via nonhomologous end joining (GO:0006303)2.69774290
70folic acid metabolic process (GO:0046655)2.69525448
71protein export from nucleus (GO:0006611)2.67388092
72dicarboxylic acid biosynthetic process (GO:0043650)2.65905673
73positive regulation of protein export from nucleus (GO:0046827)2.65695089
74regulation of centrosome cycle (GO:0046605)2.64723480
75regulation of centrosome duplication (GO:0010824)2.64505061
76ribosome assembly (GO:0042255)2.61964411
77mitotic recombination (GO:0006312)2.60307843
78protein complex localization (GO:0031503)2.57650542
79glutamine metabolic process (GO:0006541)2.56961433
80proline metabolic process (GO:0006560)2.56607171
81activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.54610981
82positive regulation of DNA-templated transcription, initiation (GO:2000144)2.54048976
83positive regulation of DNA-dependent DNA replication (GO:2000105)2.53962227
84positive regulation of steroid biosynthetic process (GO:0010893)2.53944883
85IMP metabolic process (GO:0046040)2.53708753
86nucleotide-excision repair, DNA gap filling (GO:0006297)2.52804662
87glycosphingolipid catabolic process (GO:0046479)2.52579626
88nucleic acid transport (GO:0050657)2.52418653
89RNA transport (GO:0050658)2.52418653
90establishment of RNA localization (GO:0051236)2.52418653
91positive regulation of nuclease activity (GO:0032075)2.51873438
92negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.50923197
93RNA stabilization (GO:0043489)2.50397316
94mRNA stabilization (GO:0048255)2.50397316
95histone H3-K9 demethylation (GO:0033169)2.50023635
96negative regulation of fatty acid biosynthetic process (GO:0045717)2.49300164
97regulation of mammary gland epithelial cell proliferation (GO:0033599)2.47299383
98positive regulation vascular endothelial growth factor production (GO:0010575)2.46116665
99regulation of fever generation (GO:0031620)2.44396786
100heterochromatin organization (GO:0070828)2.43667727

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human4.94138461
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.73594392
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.47872998
4KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.20797550
5AR_21909140_ChIP-Seq_LNCAP_Human2.87475346
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.82795744
7E2F1_21310950_ChIP-Seq_MCF-7_Human2.72892331
8MYC_22102868_ChIP-Seq_BL_Human2.56157414
9PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.41475335
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.39067000
11CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.29242403
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.17158267
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.11149047
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.00087322
15E2F7_22180533_ChIP-Seq_HELA_Human12.9501291
16POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.99954916
17CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.99136350
18YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.98244448
19TFEB_21752829_ChIP-Seq_HELA_Human1.96005878
20MYC_19030024_ChIP-ChIP_MESCs_Mouse1.89251483
21MYCN_18555785_ChIP-Seq_MESCs_Mouse1.88297204
22KDM5A_27292631_Chip-Seq_BREAST_Human1.84297199
23XRN2_22483619_ChIP-Seq_HELA_Human1.81042721
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.80147731
25CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.76683163
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73732585
27ZFX_18555785_ChIP-Seq_MESCs_Mouse1.68752754
28MYC_19079543_ChIP-ChIP_MESCs_Mouse1.63490325
29ZNF263_19887448_ChIP-Seq_K562_Human1.62586039
30ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.62575832
31DCP1A_22483619_ChIP-Seq_HELA_Human1.59200873
32MYC_18358816_ChIP-ChIP_MESCs_Mouse1.57402271
33TTF2_22483619_ChIP-Seq_HELA_Human1.53943879
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.53155909
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.52598621
36GATA1_22025678_ChIP-Seq_K562_Human1.52066220
37DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.51830263
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.50367526
39ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.41752028
40NCOR1_26117541_ChIP-Seq_K562_Human1.39214187
41CIITA_25753668_ChIP-Seq_RAJI_Human1.36600561
42ESR1_15608294_ChIP-ChIP_MCF-7_Human1.35637894
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.33019617
44PKCTHETA_26484144_Chip-Seq_BREAST_Human1.30733300
45TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.30189990
46DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.29650651
47ETS1_20019798_ChIP-Seq_JURKAT_Human1.27136000
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23361492
49GABP_19822575_ChIP-Seq_HepG2_Human1.22953677
50ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21517989
51E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.21247783
52TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18148169
53CHD1_26751641_Chip-Seq_LNCaP_Human1.18027905
54FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.17257211
55CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.16772465
56CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15632925
57KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12263110
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12091473
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11982441
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11694195
61KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09178224
62KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08881790
63SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.07599283
64TP63_19390658_ChIP-ChIP_HaCaT_Human1.07296989
65KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.05691149
66CLOCK_20551151_ChIP-Seq_293T_Human1.04344186
67NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.04053626
68UBF1/2_26484160_Chip-Seq_HMECs_Human1.01854018
69ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00838813
70GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99697840
71HNF4A_19822575_ChIP-Seq_HepG2_Human0.95186380
72SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95023602
73FOXA2_19822575_ChIP-Seq_HepG2_Human0.94650699
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94037940
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91443312
76NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90646141
77DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90320401
78NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.89756561
79JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.89534569
80SALL1_21062744_ChIP-ChIP_HESCs_Human0.89420216
81GATA1_19941826_ChIP-Seq_K562_Human0.88694502
82GATA6_25053715_ChIP-Seq_YYC3_Human0.88664389
83VDR_21846776_ChIP-Seq_THP-1_Human0.88281721
84MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.87964524
85HOXB4_20404135_ChIP-ChIP_EML_Mouse0.86564036
86TP63_17297297_ChIP-ChIP_HaCaT_Human0.86258412
87P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86208207
88TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.84526630
89KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.83013301
90MYB_21317192_ChIP-Seq_ERMYB_Mouse0.82712485
91ATF3_27146783_Chip-Seq_COLON_Human0.82321760
92HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.81790054
93TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.81726949
94CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.80405967
95GATA4_21415370_ChIP-Seq_HL-1_Mouse0.79128104
96STAT3_1855785_ChIP-Seq_MESCs_Mouse0.78720110
97BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.77788927
98SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.77527425
99FOXP3_21729870_ChIP-Seq_TREG_Human0.76010748
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.74480283

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.91342863
2MP0010352_gastrointestinal_tract_polyps3.78308578
3MP0003111_abnormal_nucleus_morphology3.74984487
4MP0005451_abnormal_body_composition3.54959220
5MP0010094_abnormal_chromosome_stability3.49262873
6MP0002009_preneoplasia3.12825282
7MP0008007_abnormal_cellular_replicative2.62923094
8MP0002877_abnormal_melanocyte_morpholog2.54781398
9MP0004233_abnormal_muscle_weight2.49998010
10MP0003077_abnormal_cell_cycle2.48373732
11MP0003303_peritoneal_inflammation2.46297674
12MP0003656_abnormal_erythrocyte_physiolo2.45190544
13MP0002139_abnormal_hepatobiliary_system2.40235454
14MP0009697_abnormal_copulation2.39549411
15MP0005076_abnormal_cell_differentiation2.38832112
16MP0004957_abnormal_blastocyst_morpholog2.15850434
17MP0005410_abnormal_fertilization2.11620031
18MP0003693_abnormal_embryo_hatching2.08819063
19MP0010307_abnormal_tumor_latency1.91817802
20MP0008058_abnormal_DNA_repair1.91753364
21MP0003172_abnormal_lysosome_physiology1.81372245
22MP0003123_paternal_imprinting1.76146620
23MP0005058_abnormal_lysosome_morphology1.73980497
24MP0001730_embryonic_growth_arrest1.65045483
25MP0008932_abnormal_embryonic_tissue1.64574742
26MP0000350_abnormal_cell_proliferation1.60523271
27MP0001661_extended_life_span1.58025398
28MP0000678_abnormal_parathyroid_gland1.50430543
29MP0003984_embryonic_growth_retardation1.48587192
30MP0001915_intracranial_hemorrhage1.47472485
31MP0001672_abnormal_embryogenesis/_devel1.46965916
32MP0005380_embryogenesis_phenotype1.46965916
33MP0001346_abnormal_lacrimal_gland1.45153609
34MP0004808_abnormal_hematopoietic_stem1.44577543
35MP0005409_darkened_coat_color1.43329592
36MP0003705_abnormal_hypodermis_morpholog1.41910694
37MP0002088_abnormal_embryonic_growth/wei1.39700457
38MP0002396_abnormal_hematopoietic_system1.35546117
39MP0002006_tumorigenesis1.31649170
40MP0004185_abnormal_adipocyte_glucose1.30397233
41MP0002086_abnormal_extraembryonic_tissu1.22881926
42MP0001697_abnormal_embryo_size1.19005360
43MP0002080_prenatal_lethality1.18499687
44MP0005167_abnormal_blood-brain_barrier1.16047121
45MP0001929_abnormal_gametogenesis1.10284899
46MP0003221_abnormal_cardiomyocyte_apopto1.08829089
47MP0000609_abnormal_liver_physiology1.07657152
48MP0000313_abnormal_cell_death1.07380024
49MP0003195_calcinosis1.04370559
50MP0009278_abnormal_bone_marrow1.03546756
51MP0009840_abnormal_foam_cell1.03037865
52MP0003385_abnormal_body_wall1.01776221
53MP0003698_abnormal_male_reproductive0.98135106
54MP0001545_abnormal_hematopoietic_system0.97441594
55MP0005397_hematopoietic_system_phenotyp0.97441594
56MP0010234_abnormal_vibrissa_follicle0.95788089
57MP0005621_abnormal_cell_physiology0.94281685
58MP0003943_abnormal_hepatobiliary_system0.93053535
59MP0005187_abnormal_penis_morphology0.92140562
60MP0003942_abnormal_urinary_system0.90034724
61MP0000003_abnormal_adipose_tissue0.89905106
62MP0005384_cellular_phenotype0.89554244
63MP0003786_premature_aging0.87924189
64MP0009115_abnormal_fat_cell0.87473442
65MP0005666_abnormal_adipose_tissue0.87451776
66MP0000358_abnormal_cell_content/0.86442070
67MP0002092_abnormal_eye_morphology0.86243364
68MP0002970_abnormal_white_adipose0.84804567
69MP0004197_abnormal_fetal_growth/weight/0.83293907
70MP0001270_distended_abdomen0.82840267
71MP0000598_abnormal_liver_morphology0.82368800
72MP0002084_abnormal_developmental_patter0.82032507
73MP0002161_abnormal_fertility/fecundity0.81424876
74MP0000428_abnormal_craniofacial_morphol0.77941210
75MP0005266_abnormal_metabolism0.76973348
76MP0005647_abnormal_sex_gland0.74836387
77MP0001666_abnormal_nutrient_absorption0.74472275
78MP0003115_abnormal_respiratory_system0.73689312
79MP0002085_abnormal_embryonic_tissue0.73227925
80MP0003300_gastrointestinal_ulcer0.71693617
81MP0000371_diluted_coat_color0.70634296
82MP0001727_abnormal_embryo_implantation0.69863130
83MP0003632_abnormal_nervous_system0.69238793
84MP0006035_abnormal_mitochondrial_morpho0.68122415
85MP0005375_adipose_tissue_phenotype0.67740743
86MP0003868_abnormal_feces_composition0.66708311
87MP0008995_early_reproductive_senescence0.64705071
88MP0003315_abnormal_perineum_morphology0.64639858
89MP0003122_maternal_imprinting0.64041111
90MP0002697_abnormal_eye_size0.63245480
91MP0002210_abnormal_sex_determination0.62972505
92MP0002075_abnormal_coat/hair_pigmentati0.62462765
93MP0005220_abnormal_exocrine_pancreas0.61926202
94MP0005670_abnormal_white_adipose0.60561936
95MP0003453_abnormal_keratinocyte_physiol0.60401310
96MP0004947_skin_inflammation0.59941064
97MP0009046_muscle_twitch0.59539023
98MP0001186_pigmentation_phenotype0.59222265
99MP0005310_abnormal_salivary_gland0.59186745
100MP0010329_abnormal_lipoprotein_level0.58983698

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)3.87010111
2Chromsome breakage (HP:0040012)3.79635728
3Deep venous thrombosis (HP:0002625)3.79577273
4Septate vagina (HP:0001153)3.67174125
5Submucous cleft hard palate (HP:0000176)3.52515730
6Dysmetric saccades (HP:0000641)3.25236890
7Ankyloglossia (HP:0010296)3.22164406
8Relative macrocephaly (HP:0004482)3.11556688
9Heterotopia (HP:0002282)3.00507609
10Overlapping toe (HP:0001845)2.96550347
11Abnormality of cochlea (HP:0000375)2.83491803
12Pancreatic islet-cell hyperplasia (HP:0004510)2.82535878
13Sandal gap (HP:0001852)2.60417343
14Abnormal large intestine physiology (HP:0012700)2.59344114
15Abnormality of the common coagulation pathway (HP:0010990)2.58940590
16Abnormal foot bone ossification (HP:0010675)2.57034885
17Insidious onset (HP:0003587)2.56969662
18Termporal pattern (HP:0011008)2.56969662
19Acanthocytosis (HP:0001927)2.52154306
20Lower limb hyperreflexia (HP:0002395)2.50114618
21Truncus arteriosus (HP:0001660)2.47526559
22Asymmetry of the thorax (HP:0001555)2.43497901
23Bowel incontinence (HP:0002607)2.40445010
24Abnormality of glycolysis (HP:0004366)2.40390889
25Obsessive-compulsive behavior (HP:0000722)2.39433215
26Acute myeloid leukemia (HP:0004808)2.39021697
27Abnormality of oral frenula (HP:0000190)2.38963340
28Acute lymphatic leukemia (HP:0006721)2.38926330
29Papillary thyroid carcinoma (HP:0002895)2.36908652
30Increased nuchal translucency (HP:0010880)2.35451366
3111 pairs of ribs (HP:0000878)2.34441085
32Abnormality of chromosome segregation (HP:0002916)2.29779801
33Orthostatic hypotension (HP:0001278)2.27829239
34Cubitus valgus (HP:0002967)2.25324537
35Limited elbow extension (HP:0001377)2.25282448
36Deep philtrum (HP:0002002)2.23998856
37Macroorchidism (HP:0000053)2.20799872
38Flat acetabular roof (HP:0003180)2.18780687
39Cortical dysplasia (HP:0002539)2.17711682
40Hypobetalipoproteinemia (HP:0003563)2.12605610
41Abnormality of the pancreatic islet cells (HP:0006476)2.10613506
42Abnormality of endocrine pancreas physiology (HP:0012093)2.10613506
43Subacute progressive viral hepatitis (HP:0006572)2.10075193
44Long eyelashes (HP:0000527)2.04166139
45Limb hypertonia (HP:0002509)2.03731324
46Abnormal tarsal ossification (HP:0008369)2.02655586
47Myocardial infarction (HP:0001658)2.02425054
48Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.01532448
49Renovascular hypertension (HP:0100817)2.01136465
50Sparse lateral eyebrow (HP:0005338)1.99497301
51Microvesicular hepatic steatosis (HP:0001414)1.96749330
52Self-mutilation (HP:0000742)1.96465207
53Increased serum pyruvate (HP:0003542)1.93424969
54Abnormality of the lumbar spine (HP:0100712)1.93398147
55Personality changes (HP:0000751)1.91908929
56Attention deficit hyperactivity disorder (HP:0007018)1.91666365
57Abnormality of chromosome stability (HP:0003220)1.91641769
58Coarse hair (HP:0002208)1.91292314
59Broad palm (HP:0001169)1.89545075
60Abnormality of carpal bone ossification (HP:0006257)1.86834638
61Tubulointerstitial nephritis (HP:0001970)1.84645729
62Deviation of the thumb (HP:0009603)1.82359376
63Abnormality of the astrocytes (HP:0100707)1.81819852
64Astrocytoma (HP:0009592)1.81819852
65Hypolipoproteinemia (HP:0010981)1.81526312
66Cutis marmorata (HP:0000965)1.79927977
67Proximal placement of thumb (HP:0009623)1.79669230
68Medulloblastoma (HP:0002885)1.77989059
69Abnormality of the fingertips (HP:0001211)1.77121151
70Hammertoe (HP:0001765)1.76513266
71Menstrual irregularities (HP:0000858)1.75940256
72Progressive hearing impairment (HP:0001730)1.75700029
73Cafe-au-lait spot (HP:0000957)1.75326650
74Abnormality of the tricuspid valve (HP:0001702)1.74214559
75Upper limb muscle weakness (HP:0003484)1.72694045
76Smooth philtrum (HP:0000319)1.72117874
77Nephroblastoma (Wilms tumor) (HP:0002667)1.71992196
78Abnormal gallbladder physiology (HP:0012438)1.70330868
79Cholecystitis (HP:0001082)1.70330868
80Deep palmar crease (HP:0006191)1.69820599
81Abnormal ossification of hand bones (HP:0005921)1.69424576
82Leiomyosarcoma (HP:0100243)1.69118085
83Uterine leiomyosarcoma (HP:0002891)1.69118085
84Hemorrhage of the eye (HP:0011885)1.67969859
85Renal cell carcinoma (HP:0005584)1.67273028
86Open mouth (HP:0000194)1.66238760
87Capillary hemangiomas (HP:0005306)1.66011191
88Drooling (HP:0002307)1.64617328
89Embryonal neoplasm (HP:0002898)1.64511340
90Patellar dislocation (HP:0002999)1.63343059
91Premature ovarian failure (HP:0008209)1.63307104
92Abnormality of the acetabulum (HP:0003170)1.62900517
93Abnormal hand bone ossification (HP:0010660)1.62705721
94Anal stenosis (HP:0002025)1.61706020
95Volvulus (HP:0002580)1.61537243
96Disproportionate tall stature (HP:0001519)1.61528176
97Myelodysplasia (HP:0002863)1.60786030
98Morphological abnormality of the inner ear (HP:0011390)1.60776352
99Hypercholesterolemia (HP:0003124)1.60697356
100Hyperacusis (HP:0010780)1.57645396

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK36.20760949
2CDK124.49082288
3EEF2K3.82783738
4ICK3.14486656
5AKT32.97117383
6BRD42.88860384
7CAMK1G2.71140050
8CAMK1D2.54392446
9CDC72.24590141
10PLK42.22256080
11TRIB32.06667255
12TTK1.99552179
13KSR21.93047825
14SRPK11.89238722
15DDR21.73124162
16SCYL21.62823568
17EIF2AK11.45687616
18IRAK21.43307715
19CHEK21.40367868
20MAP3K21.39324452
21TYRO31.26360465
22FGFR31.21653866
23PNCK1.19730651
24CLK11.19421961
25MAPK111.18431019
26NTRK31.18400568
27MAP3K141.18296213
28WNK11.17231382
29ATR1.16635807
30CHEK11.15595542
31CDK41.15108659
32LATS21.13361824
33BMPR21.13055071
34SMG11.12793795
35MTOR1.12356992
36LATS11.08712600
37RAF11.04549356
38CDK71.04440575
39NEK11.03542862
40MAP3K101.01578499
41CDK61.01574733
42FGFR40.99322261
43PDGFRA0.99200313
44CDK80.98924428
45BRAF0.94059723
46ATM0.91886689
47MST1R0.90029189
48IRAK40.86221062
49KSR10.85910113
50INSRR0.85227599
51EIF2AK30.83191869
52CDK20.74240300
53RPS6KB10.73317324
54BRSK20.72745048
55CDK10.71441071
56PRKAA20.69220718
57IRAK10.66754129
58PIM20.62874054
59PRKAA10.62112250
60MAP3K80.60258200
61ALK0.59314632
62CSNK1E0.57431483
63CCNB10.56527001
64PDPK10.55862523
65SIK20.55248325
66PRPF4B0.54382843
67MKNK10.53990783
68WEE10.52932255
69MAP3K40.51860892
70CSNK1A1L0.51268791
71MAPK100.51131415
72TRPM70.50335812
73SGK30.49037370
74CDK90.49027191
75CAMKK20.48200944
76RET0.46931097
77PKN20.45952809
78CDK30.45118972
79GSK3B0.45034475
80WNK40.44304918
81MAPK140.43593402
82MATK0.42578553
83PAK20.41313280
84NEK20.41135668
85AURKB0.40559635
86NEK90.40535947
87RIPK40.40396339
88PDK10.39241024
89PRKDC0.39168769
90STK30.37661540
91RIPK10.36522497
92NME20.34048754
93MAPKAPK50.33247502
94MAP3K10.33230907
95PDGFRB0.32613449
96AKT10.31945222
97SGK10.31916858
98PLK10.30312223
99RPS6KB20.30182428
100MAP2K30.29989516

Predicted pathways (KEGG)

RankGene SetZ-score
1Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.04829580
2Fatty acid biosynthesis_Homo sapiens_hsa000612.98933074
3DNA replication_Homo sapiens_hsa030302.91901771
4One carbon pool by folate_Homo sapiens_hsa006702.46417864
5Other glycan degradation_Homo sapiens_hsa005112.14045934
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.07271611
7Cell cycle_Homo sapiens_hsa041102.01652305
8Chronic myeloid leukemia_Homo sapiens_hsa052201.96036436
9RNA transport_Homo sapiens_hsa030131.92286956
10Non-small cell lung cancer_Homo sapiens_hsa052231.78098240
11Bladder cancer_Homo sapiens_hsa052191.75203027
12Mismatch repair_Homo sapiens_hsa034301.72627778
13mTOR signaling pathway_Homo sapiens_hsa041501.72397971
14Steroid biosynthesis_Homo sapiens_hsa001001.69153704
15Non-homologous end-joining_Homo sapiens_hsa034501.66993747
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.65330871
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.63977499
18Type II diabetes mellitus_Homo sapiens_hsa049301.62908381
19Lysine degradation_Homo sapiens_hsa003101.53520255
20mRNA surveillance pathway_Homo sapiens_hsa030151.48139585
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.47036927
22Pancreatic cancer_Homo sapiens_hsa052121.42987188
23Prion diseases_Homo sapiens_hsa050201.41869709
24Adipocytokine signaling pathway_Homo sapiens_hsa049201.41012615
25Nucleotide excision repair_Homo sapiens_hsa034201.40537727
26Acute myeloid leukemia_Homo sapiens_hsa052211.35643014
27AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.33337508
28Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.32688020
29Spliceosome_Homo sapiens_hsa030401.26385863
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.20616291
31MicroRNAs in cancer_Homo sapiens_hsa052061.19589033
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.18856007
33Glioma_Homo sapiens_hsa052141.17999079
34Thyroid cancer_Homo sapiens_hsa052161.16447366
35Longevity regulating pathway - mammal_Homo sapiens_hsa042111.12436849
36Prostate cancer_Homo sapiens_hsa052151.08983966
37Viral carcinogenesis_Homo sapiens_hsa052031.07988151
38N-Glycan biosynthesis_Homo sapiens_hsa005101.04618587
39Fatty acid metabolism_Homo sapiens_hsa012121.03126971
40TNF signaling pathway_Homo sapiens_hsa046681.02692821
41Legionellosis_Homo sapiens_hsa051341.02005751
42Hepatitis B_Homo sapiens_hsa051611.01712021
43ErbB signaling pathway_Homo sapiens_hsa040120.99706819
44Central carbon metabolism in cancer_Homo sapiens_hsa052300.98775332
45Glycosaminoglycan degradation_Homo sapiens_hsa005310.98467196
46Thyroid hormone signaling pathway_Homo sapiens_hsa049190.97484580
47Small cell lung cancer_Homo sapiens_hsa052220.96808468
48Fanconi anemia pathway_Homo sapiens_hsa034600.94914706
49Neurotrophin signaling pathway_Homo sapiens_hsa047220.94249660
50Complement and coagulation cascades_Homo sapiens_hsa046100.93641178
51Prolactin signaling pathway_Homo sapiens_hsa049170.90831200
52Biosynthesis of amino acids_Homo sapiens_hsa012300.90549522
53Base excision repair_Homo sapiens_hsa034100.90355114
54Homologous recombination_Homo sapiens_hsa034400.88814427
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.87818488
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87792180
57Sphingolipid metabolism_Homo sapiens_hsa006000.85585501
58Insulin signaling pathway_Homo sapiens_hsa049100.84997604
59NF-kappa B signaling pathway_Homo sapiens_hsa040640.83860318
60Endometrial cancer_Homo sapiens_hsa052130.82925060
61Insulin resistance_Homo sapiens_hsa049310.82799377
62VEGF signaling pathway_Homo sapiens_hsa043700.82564707
63HIF-1 signaling pathway_Homo sapiens_hsa040660.81267009
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74712655
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71502581
66AMPK signaling pathway_Homo sapiens_hsa041520.71169823
67Alcoholism_Homo sapiens_hsa050340.69535665
68Renal cell carcinoma_Homo sapiens_hsa052110.68734955
69Vitamin B6 metabolism_Homo sapiens_hsa007500.67530270
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66391494
71Toll-like receptor signaling pathway_Homo sapiens_hsa046200.66309654
72FoxO signaling pathway_Homo sapiens_hsa040680.65954573
73Selenocompound metabolism_Homo sapiens_hsa004500.65204955
74Colorectal cancer_Homo sapiens_hsa052100.65095661
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63730974
76Inositol phosphate metabolism_Homo sapiens_hsa005620.60680231
77Thyroid hormone synthesis_Homo sapiens_hsa049180.59902470
78Influenza A_Homo sapiens_hsa051640.59097791
79Systemic lupus erythematosus_Homo sapiens_hsa053220.58985426
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58377575
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58182869
82Choline metabolism in cancer_Homo sapiens_hsa052310.57026934
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54323449
84RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.54158829
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51581078
86Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51000038
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50979370
88Pertussis_Homo sapiens_hsa051330.50725783
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50062871
90B cell receptor signaling pathway_Homo sapiens_hsa046620.49767406
91Pyrimidine metabolism_Homo sapiens_hsa002400.46311082
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45949228
93Carbon metabolism_Homo sapiens_hsa012000.45474952
94Salmonella infection_Homo sapiens_hsa051320.44641407
95Apoptosis_Homo sapiens_hsa042100.43535014
96Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42807122
97Dorso-ventral axis formation_Homo sapiens_hsa043200.42131042
98Estrogen signaling pathway_Homo sapiens_hsa049150.41518880
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.40080744
100Fructose and mannose metabolism_Homo sapiens_hsa000510.39801620

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