NCLP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)4.25473164
2DNA deamination (GO:0045006)4.07899725
3tryptophan catabolic process (GO:0006569)3.92612513
4indole-containing compound catabolic process (GO:0042436)3.92612513
5indolalkylamine catabolic process (GO:0046218)3.92612513
6negative regulation of cytosolic calcium ion concentration (GO:0051481)3.71729278
7water-soluble vitamin biosynthetic process (GO:0042364)3.69037592
8negative regulation of translation, ncRNA-mediated (GO:0040033)3.63416075
9regulation of translation, ncRNA-mediated (GO:0045974)3.63416075
10negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.63416075
11detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.61535599
12detection of light stimulus involved in sensory perception (GO:0050962)3.53875337
13detection of light stimulus involved in visual perception (GO:0050908)3.53875337
14protein K11-linked deubiquitination (GO:0035871)3.52140539
15synapsis (GO:0007129)3.49440851
16UDP-N-acetylglucosamine metabolic process (GO:0006047)3.43748611
17lactate metabolic process (GO:0006089)3.39258054
18behavioral response to nicotine (GO:0035095)3.37266328
19kidney morphogenesis (GO:0060993)3.31895706
20regulation of nuclear cell cycle DNA replication (GO:0033262)3.23158147
21piRNA metabolic process (GO:0034587)3.22581560
22L-fucose catabolic process (GO:0042355)3.17881603
23fucose catabolic process (GO:0019317)3.17881603
24L-fucose metabolic process (GO:0042354)3.17881603
25tryptophan metabolic process (GO:0006568)3.16003070
26inositol phosphate catabolic process (GO:0071545)3.13928334
27regulation of neurotransmitter uptake (GO:0051580)3.10331764
28regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.08046921
29polyol catabolic process (GO:0046174)3.06385364
30cornea development in camera-type eye (GO:0061303)3.03526420
31indolalkylamine metabolic process (GO:0006586)3.03016254
32replication fork processing (GO:0031297)2.98570342
33kynurenine metabolic process (GO:0070189)2.97726680
34cellular ketone body metabolic process (GO:0046950)2.94394262
35keratinocyte development (GO:0003334)2.93085582
36negative regulation of mast cell activation (GO:0033004)2.91961722
37regulation of glucokinase activity (GO:0033131)2.89078179
38regulation of hexokinase activity (GO:1903299)2.89078179
39cellular biogenic amine catabolic process (GO:0042402)2.88437728
40amine catabolic process (GO:0009310)2.88437728
41negative regulation of DNA-dependent DNA replication (GO:2000104)2.86842855
42recombinational repair (GO:0000725)2.84572142
43peristalsis (GO:0030432)2.83695039
44cellular response to ATP (GO:0071318)2.82743690
45positive regulation of meiosis (GO:0045836)2.82522657
46meiotic chromosome segregation (GO:0045132)2.82521102
47double-strand break repair via homologous recombination (GO:0000724)2.81655197
483-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.80932309
49purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.80932309
50protein K6-linked ubiquitination (GO:0085020)2.80306878
51respiratory chain complex IV assembly (GO:0008535)2.79091196
52membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.73299697
53ketone body metabolic process (GO:1902224)2.73132540
54positive regulation of triglyceride biosynthetic process (GO:0010867)2.72903477
55preassembly of GPI anchor in ER membrane (GO:0016254)2.71848082
56adaptation of signaling pathway (GO:0023058)2.71825728
57spinal cord motor neuron differentiation (GO:0021522)2.69958995
58aromatic amino acid family catabolic process (GO:0009074)2.68864337
59reflex (GO:0060004)2.68643238
60regulation of non-canonical Wnt signaling pathway (GO:2000050)2.67787869
61protein polyglutamylation (GO:0018095)2.66604046
62protein-cofactor linkage (GO:0018065)2.64019406
63platelet dense granule organization (GO:0060155)2.63380051
64microtubule anchoring (GO:0034453)2.63354085
65axoneme assembly (GO:0035082)2.62678606
66positive regulation of meiotic cell cycle (GO:0051446)2.62145973
67DNA methylation involved in gamete generation (GO:0043046)2.62090746
68sulfation (GO:0051923)2.61470235
69histone mRNA catabolic process (GO:0071044)2.60927011
70centriole replication (GO:0007099)2.56688812
71startle response (GO:0001964)2.55649824
72auditory receptor cell stereocilium organization (GO:0060088)2.54766210
73photoreceptor cell maintenance (GO:0045494)2.54485522
74indole-containing compound metabolic process (GO:0042430)2.54163150
75S-adenosylmethionine metabolic process (GO:0046500)2.51865624
76reciprocal DNA recombination (GO:0035825)2.50620388
77reciprocal meiotic recombination (GO:0007131)2.50620388
78gamma-aminobutyric acid transport (GO:0015812)2.50424082
79proline transport (GO:0015824)2.50220673
80dopamine transport (GO:0015872)2.48699233
81mannosylation (GO:0097502)2.47165917
82estrogen metabolic process (GO:0008210)2.45056124
83RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.44563278
84otic vesicle formation (GO:0030916)2.44371749
85maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.43751717
86embryonic epithelial tube formation (GO:0001838)2.43347266
87histone H2A acetylation (GO:0043968)2.42970085
88somatic diversification of immune receptors via somatic mutation (GO:0002566)2.42800511
89somatic hypermutation of immunoglobulin genes (GO:0016446)2.42800511
90somite development (GO:0061053)2.42143960
91neural tube formation (GO:0001841)2.41863595
92G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.41326766
93regulation of action potential (GO:0098900)2.38932970
94nephron epithelium morphogenesis (GO:0072088)2.38851412
95nephron tubule morphogenesis (GO:0072078)2.38851412
96neuronal action potential (GO:0019228)2.38302770
97regulation of telomere maintenance (GO:0032204)2.37795134
98GPI anchor metabolic process (GO:0006505)2.37135461
99transepithelial transport (GO:0070633)2.36543158
100regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.36456029

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.42807627
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.12596616
3VDR_22108803_ChIP-Seq_LS180_Human2.92652862
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.82802613
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.79490257
6GBX2_23144817_ChIP-Seq_PC3_Human2.74984443
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.67179900
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.55072966
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.43842060
10EWS_26573619_Chip-Seq_HEK293_Human2.30022528
11FUS_26573619_Chip-Seq_HEK293_Human2.27929383
12IGF1R_20145208_ChIP-Seq_DFB_Human2.24426414
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.16851420
14P300_19829295_ChIP-Seq_ESCs_Human2.06619384
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.02335977
16ER_23166858_ChIP-Seq_MCF-7_Human1.86869003
17FLI1_27457419_Chip-Seq_LIVER_Mouse1.86028050
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.85558090
19NOTCH1_21737748_ChIP-Seq_TLL_Human1.85385043
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.84540352
21AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.84013698
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77086618
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72547546
24MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.71051628
25BCAT_22108803_ChIP-Seq_LS180_Human1.70706116
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.63865611
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63180698
28STAT3_23295773_ChIP-Seq_U87_Human1.63155728
29MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.62304900
30SMAD4_21799915_ChIP-Seq_A2780_Human1.59028607
31EZH2_22144423_ChIP-Seq_EOC_Human1.56849502
32TCF4_23295773_ChIP-Seq_U87_Human1.53371916
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52664850
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.52458245
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.51559744
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50562060
37NR3C1_21868756_ChIP-Seq_MCF10A_Human1.49235438
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.47752197
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.46796705
40TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46796705
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46226698
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45395164
43EZH2_27294783_Chip-Seq_NPCs_Mouse1.43665875
44AR_25329375_ChIP-Seq_VCAP_Human1.41332388
45GABP_17652178_ChIP-ChIP_JURKAT_Human1.40356809
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.40170789
47NFE2_27457419_Chip-Seq_LIVER_Mouse1.39421606
48TAF15_26573619_Chip-Seq_HEK293_Human1.37376745
49FOXA1_25329375_ChIP-Seq_VCAP_Human1.35179648
50FOXA1_27270436_Chip-Seq_PROSTATE_Human1.35179648
51TCF4_22108803_ChIP-Seq_LS180_Human1.34730991
52KLF5_20875108_ChIP-Seq_MESCs_Mouse1.34414840
53MYC_18940864_ChIP-ChIP_HL60_Human1.33750290
54CDX2_22108803_ChIP-Seq_LS180_Human1.33594148
55SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33464703
56KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.30781715
57NANOG_18555785_Chip-Seq_ESCs_Mouse1.30534205
58CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30148733
59NANOG_19829295_ChIP-Seq_ESCs_Human1.29214669
60SOX2_19829295_ChIP-Seq_ESCs_Human1.29214669
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27997897
62EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.27433818
63CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.27199614
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27115196
65CBP_20019798_ChIP-Seq_JUKART_Human1.27115196
66ELK1_19687146_ChIP-ChIP_HELA_Human1.27066323
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.26912890
68GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26743367
69PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25704823
70CRX_20693478_ChIP-Seq_RETINA_Mouse1.24449733
71TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23843611
72TP53_22573176_ChIP-Seq_HFKS_Human1.22024520
73EST1_17652178_ChIP-ChIP_JURKAT_Human1.21936899
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20145937
75FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20079171
76RUNX2_22187159_ChIP-Seq_PCA_Human1.18558487
77FLI1_21867929_ChIP-Seq_TH2_Mouse1.18460633
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18176927
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18087762
80SMAD4_21741376_ChIP-Seq_EPCs_Human1.17574367
81P53_22387025_ChIP-Seq_ESCs_Mouse1.12998680
82E2F1_18555785_Chip-Seq_ESCs_Mouse1.12269128
83PRDM14_20953172_ChIP-Seq_ESCs_Human1.09531445
84IRF1_19129219_ChIP-ChIP_H3396_Human1.09048778
85ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08157576
86RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08126894
87FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07009929
88OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06683597
89RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05603300
90NCOR_22424771_ChIP-Seq_293T_Human1.05496022
91BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05303247
92STAT3_18555785_Chip-Seq_ESCs_Mouse1.04813874
93HOXB7_26014856_ChIP-Seq_BT474_Human1.03757379
94TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02727474
95REST_21632747_ChIP-Seq_MESCs_Mouse1.01775749
96EGR1_23403033_ChIP-Seq_LIVER_Mouse1.01438947
97SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01314510
98SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00793369
99HTT_18923047_ChIP-ChIP_STHdh_Human1.00137624
100GATA3_21878914_ChIP-Seq_MCF-7_Human0.99508423

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.38724835
2MP0002837_dystrophic_cardiac_calcinosis2.77945659
3MP0008877_abnormal_DNA_methylation2.72078823
4MP0006072_abnormal_retinal_apoptosis2.66983676
5MP0002102_abnormal_ear_morphology2.38313675
6MP0000569_abnormal_digit_pigmentation2.35754924
7MP0005551_abnormal_eye_electrophysiolog2.34304826
8MP0005646_abnormal_pituitary_gland2.32665754
9MP0005379_endocrine/exocrine_gland_phen2.31858624
10MP0002876_abnormal_thyroid_physiology2.10633035
11MP0000372_irregular_coat_pigmentation2.09709809
12MP0000427_abnormal_hair_cycle2.03604136
13MP0003646_muscle_fatigue2.00907003
14MP0002160_abnormal_reproductive_system1.98445205
15MP0005253_abnormal_eye_physiology1.97765862
16MP0004885_abnormal_endolymph1.95049405
17MP0008058_abnormal_DNA_repair1.84971645
18MP0008875_abnormal_xenobiotic_pharmacok1.80103937
19MP0003890_abnormal_embryonic-extraembry1.80025821
20MP0008872_abnormal_physiological_respon1.78968037
21MP0003011_delayed_dark_adaptation1.77961914
22MP0005389_reproductive_system_phenotype1.75584814
23MP0003880_abnormal_central_pattern1.70844773
24MP0002938_white_spotting1.68393456
25MP0002163_abnormal_gland_morphology1.67055309
26MP0004145_abnormal_muscle_electrophysio1.65528356
27MP0005645_abnormal_hypothalamus_physiol1.65362667
28MP0002254_reproductive_system_inflammat1.63174918
29MP0001485_abnormal_pinna_reflex1.62158587
30MP0005174_abnormal_tail_pigmentation1.55728523
31MP0006292_abnormal_olfactory_placode1.55099833
32MP0004142_abnormal_muscle_tone1.55003904
33MP0009046_muscle_twitch1.52997500
34MP0001986_abnormal_taste_sensitivity1.50219162
35MP0000383_abnormal_hair_follicle1.47514509
36MP0003718_maternal_effect1.47513478
37MP0001968_abnormal_touch/_nociception1.47103001
38MP0000631_abnormal_neuroendocrine_gland1.45792307
39MP0005408_hypopigmentation1.43906712
40MP0005084_abnormal_gallbladder_morpholo1.39009760
41MP0003787_abnormal_imprinting1.37415104
42MP0005075_abnormal_melanosome_morpholog1.37213940
43MP0009745_abnormal_behavioral_response1.36585582
44MP0000015_abnormal_ear_pigmentation1.35496236
45MP0001486_abnormal_startle_reflex1.34679385
46MP0005377_hearing/vestibular/ear_phenot1.33594771
47MP0003878_abnormal_ear_physiology1.33594771
48MP0004133_heterotaxia1.31939255
49MP0001919_abnormal_reproductive_system1.24118173
50MP0003136_yellow_coat_color1.23747251
51MP0003567_abnormal_fetal_cardiomyocyte1.23388038
52MP0005367_renal/urinary_system_phenotyp1.23341165
53MP0000516_abnormal_urinary_system1.23341165
54MP0003786_premature_aging1.21586546
55MP0001501_abnormal_sleep_pattern1.19029062
56MP0002095_abnormal_skin_pigmentation1.17013776
57MP0002638_abnormal_pupillary_reflex1.16927641
58MP0002736_abnormal_nociception_after1.14222411
59MP0004742_abnormal_vestibular_system1.13577503
60MP0008057_abnormal_DNA_replication1.11480243
61MP0006276_abnormal_autonomic_nervous1.08891133
62MP0000647_abnormal_sebaceous_gland1.07198817
63MP0002272_abnormal_nervous_system1.06876917
64MP0001764_abnormal_homeostasis1.06641535
65MP0009780_abnormal_chondrocyte_physiolo1.04976407
66MP0005647_abnormal_sex_gland1.04408372
67MP0001293_anophthalmia1.02228332
68MP0008775_abnormal_heart_ventricle1.01267908
69MP0010094_abnormal_chromosome_stability1.01205756
70MP0004043_abnormal_pH_regulation1.00484748
71MP0002557_abnormal_social/conspecific_i1.00390389
72MP0002928_abnormal_bile_duct0.98833130
73MP0003937_abnormal_limbs/digits/tail_de0.97350093
74MP0005195_abnormal_posterior_eye0.96072202
75MP0002735_abnormal_chemical_nociception0.95930730
76MP0001944_abnormal_pancreas_morphology0.93673433
77MP0001324_abnormal_eye_pigmentation0.87921566
78MP0004019_abnormal_vitamin_homeostasis0.87866240
79MP0005395_other_phenotype0.86200992
80MP0002751_abnormal_autonomic_nervous0.86098736
81MP0001529_abnormal_vocalization0.86047717
82MP0003693_abnormal_embryo_hatching0.85902482
83MP0005391_vision/eye_phenotype0.85070992
84MP0005386_behavior/neurological_phenoty0.84379692
85MP0004924_abnormal_behavior0.84379692
86MP0002064_seizures0.84359095
87MP0000653_abnormal_sex_gland0.83953955
88MP0003698_abnormal_male_reproductive0.83674003
89MP0010678_abnormal_skin_adnexa0.83412049
90MP0005332_abnormal_amino_acid0.82960532
91MP0010386_abnormal_urinary_bladder0.82657591
92MP0003252_abnormal_bile_duct0.81823948
93MP0002138_abnormal_hepatobiliary_system0.81000875
94MP0003943_abnormal_hepatobiliary_system0.80959356
95MP0001984_abnormal_olfaction0.80814938
96MP0004147_increased_porphyrin_level0.80712946
97MP0002693_abnormal_pancreas_physiology0.79665170
98MP0002184_abnormal_innervation0.79574479
99MP0002210_abnormal_sex_determination0.78962106
100MP0002229_neurodegeneration0.78946776

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.22160059
2Pancreatic fibrosis (HP:0100732)4.14873695
3Molar tooth sign on MRI (HP:0002419)4.11249952
4Abnormality of midbrain morphology (HP:0002418)4.11249952
5True hermaphroditism (HP:0010459)3.84555560
6Congenital stationary night blindness (HP:0007642)3.70732006
7Pendular nystagmus (HP:0012043)3.50857475
8Nephronophthisis (HP:0000090)3.40381515
9Chronic hepatic failure (HP:0100626)3.33677897
10Abnormality of the renal cortex (HP:0011035)3.24981597
11Intestinal atresia (HP:0011100)3.08365320
12Abnormality of the renal medulla (HP:0100957)3.07139037
13Abnormal rod and cone electroretinograms (HP:0008323)2.82664936
14Attenuation of retinal blood vessels (HP:0007843)2.81254554
15Hyperventilation (HP:0002883)2.80690160
16Methylmalonic acidemia (HP:0002912)2.77906996
17Cystic liver disease (HP:0006706)2.77855944
18Abolished electroretinogram (ERG) (HP:0000550)2.59996436
19Gaze-evoked nystagmus (HP:0000640)2.56878448
20Renal cortical cysts (HP:0000803)2.54118624
21Furrowed tongue (HP:0000221)2.45833444
22Keratoconus (HP:0000563)2.45566927
23Increased corneal curvature (HP:0100692)2.45566927
24Bile duct proliferation (HP:0001408)2.43967441
25Abnormal biliary tract physiology (HP:0012439)2.43967441
26Thyroiditis (HP:0100646)2.38994616
27Hemiparesis (HP:0001269)2.35532457
28Absent rod-and cone-mediated responses on ERG (HP:0007688)2.35055413
29Aplasia/Hypoplasia of the tongue (HP:0010295)2.33587891
30Tubular atrophy (HP:0000092)2.33250111
31Ketoacidosis (HP:0001993)2.32700176
32Abnormality of the nasal septum (HP:0000419)2.32242610
33Congenital sensorineural hearing impairment (HP:0008527)2.30258385
34Small hand (HP:0200055)2.28388297
35Anencephaly (HP:0002323)2.27504794
36Chorioretinal atrophy (HP:0000533)2.23612744
37Sclerocornea (HP:0000647)2.22820054
38Abnormality of the middle phalanges of the toes (HP:0010183)2.16706914
39Abnormality of vitamin B metabolism (HP:0004340)2.15618392
40Volvulus (HP:0002580)2.14457062
41Bony spicule pigmentary retinopathy (HP:0007737)2.13891458
42Methylmalonic aciduria (HP:0012120)2.10824276
43Hypothermia (HP:0002045)2.07667038
44Stomach cancer (HP:0012126)2.06925964
45Chromsome breakage (HP:0040012)2.06668296
46Abnormal drinking behavior (HP:0030082)2.06080764
47Polydipsia (HP:0001959)2.06080764
48Gastrointestinal atresia (HP:0002589)2.05829286
49Progressive cerebellar ataxia (HP:0002073)2.05447033
50Shawl scrotum (HP:0000049)2.04566215
51Abnormality of macular pigmentation (HP:0008002)2.03249433
52Ketosis (HP:0001946)1.99160435
53Abnormality of the ileum (HP:0001549)1.96854886
54Large for gestational age (HP:0001520)1.95602608
55Hyperglycinemia (HP:0002154)1.94708858
56Progressive inability to walk (HP:0002505)1.94346990
57Aplasia/Hypoplasia involving the musculature (HP:0001460)1.93776306
58Meckel diverticulum (HP:0002245)1.93037739
59Male pseudohermaphroditism (HP:0000037)1.92185932
60Medial flaring of the eyebrow (HP:0010747)1.91896056
61Congenital hepatic fibrosis (HP:0002612)1.89167477
62Concave nail (HP:0001598)1.89029738
63Decreased central vision (HP:0007663)1.87820250
64Aplasia/Hypoplasia of the uvula (HP:0010293)1.85017930
65Hyperinsulinemic hypoglycemia (HP:0000825)1.85016777
66Abnormality of the proximal phalanges of the hand (HP:0009834)1.84389859
67Hypoplasia of the uterus (HP:0000013)1.84309557
68Chromosomal breakage induced by crosslinking agents (HP:0003221)1.82906274
69Aplasia/hypoplasia of the uterus (HP:0008684)1.82861621
70Abnormality of the phalanges of the 2nd finger (HP:0009541)1.80904898
71Hypoproteinemia (HP:0003075)1.80647421
72Abnormality of the vitamin B12 metabolism (HP:0004341)1.80213631
73Severe visual impairment (HP:0001141)1.79759037
74Hip dysplasia (HP:0001385)1.78504676
75Pancreatic islet-cell hyperplasia (HP:0004510)1.78284056
76Hypoplastic iliac wings (HP:0002866)1.76001145
77Broad-based gait (HP:0002136)1.75954894
78Dialeptic seizures (HP:0011146)1.75179459
79Abnormality of vitamin metabolism (HP:0100508)1.73433972
80Short hallux (HP:0010109)1.72807227
81Tubulointerstitial abnormality (HP:0001969)1.72643736
82Febrile seizures (HP:0002373)1.72524084
83Hamartoma of the eye (HP:0010568)1.71597870
84Abnormality of the neuromuscular junction (HP:0003398)1.70050097
85Fatigable weakness (HP:0003473)1.70050097
86Polyuria (HP:0000103)1.70013282
87Genetic anticipation (HP:0003743)1.69571056
88Inability to walk (HP:0002540)1.69245743
89Epidermoid cyst (HP:0200040)1.68731613
90Highly arched eyebrow (HP:0002553)1.67499041
91Oculomotor apraxia (HP:0000657)1.67407273
92Abnormality of the pancreatic islet cells (HP:0006476)1.66147088
93Abnormality of endocrine pancreas physiology (HP:0012093)1.66147088
94Aplasia/Hypoplasia of the tibia (HP:0005772)1.65601061
95Neoplasm of the adrenal cortex (HP:0100641)1.65505473
96Aplasia/Hypoplasia of the hallux (HP:0008362)1.65294641
97Sloping forehead (HP:0000340)1.64943010
98Type II lissencephaly (HP:0007260)1.64887260
99Supernumerary spleens (HP:0009799)1.63517736
100Preaxial hand polydactyly (HP:0001177)1.63303477

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.08526095
2BMPR1B2.95597799
3MAP4K22.81867602
4NUAK12.77500946
5ADRBK22.71955862
6INSRR2.54019053
7GRK12.41690791
8WNK32.39307144
9ACVR1B2.05793839
10TNIK1.96700700
11MKNK21.92648495
12PINK11.83385682
13MST41.83271372
14ZAK1.81414354
15PNCK1.71470506
16OXSR11.68467382
17FGFR21.68455037
18STK391.67212569
19WEE11.59784713
20EIF2AK31.58751623
21PLK21.46790813
22WNK41.45560473
23MAPK131.40735510
24MAPKAPK31.36206862
25MUSK1.23641452
26STK31.22290372
27AKT31.19965547
28STK161.18699616
29PLK31.18292127
30FLT31.16403827
31PAK31.16274553
32NLK1.12146630
33CASK1.07651847
34NTRK31.06795926
35PRKCE1.04023271
36TRIM280.98225964
37BRSK20.96924406
38FER0.94290569
39TLK10.89841008
40DAPK20.89071447
41LATS10.88466027
42PDK20.84607311
43VRK10.83970690
44STK38L0.83007903
45MKNK10.82001779
46ADRBK10.81921103
47DYRK20.80853168
48CSNK1G10.79530233
49PLK40.74423041
50TGFBR10.73992528
51NEK10.72620469
52TXK0.70666027
53BUB10.68787983
54ERBB30.64885876
55FGFR30.64556231
56PRKCG0.64295826
57PRKCI0.62318019
58PRKAA10.61996795
59CAMK1G0.56893972
60FGFR10.56631435
61CSNK1G20.56551260
62MARK10.56093361
63IKBKB0.54282273
64PRKCH0.51317229
65TSSK60.49483516
66ATM0.48868019
67STK110.48477923
68PLK10.47547027
69STK240.47015471
70CCNB10.46840985
71ATR0.46638742
72TEC0.46580649
73CSNK1A10.45741229
74PTK2B0.44963772
75CDK30.43660660
76PHKG20.42019384
77PHKG10.42019384
78MAP2K60.41370205
79PBK0.41299956
80DYRK30.41131536
81PIK3CA0.40739723
82CSNK1G30.39526231
83TNK20.38812732
84VRK20.38803317
85SRPK10.38355406
86EIF2AK10.37869561
87SGK20.37400623
88CAMK2A0.37210135
89PRKACA0.36105306
90GRK50.35549613
91IRAK10.35314503
92PRKAA20.35309638
93NEK20.34696777
94MAP3K70.34459309
95MAP3K40.34387385
96DAPK10.34260672
97MELK0.33810614
98CSNK1A1L0.33528475
99MAP2K10.32574257
100CHEK20.31682682

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.71846946
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.64410151
3Caffeine metabolism_Homo sapiens_hsa002322.52861151
4Butanoate metabolism_Homo sapiens_hsa006502.39228515
5Phototransduction_Homo sapiens_hsa047442.37872821
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.36114305
7Homologous recombination_Homo sapiens_hsa034402.27430267
8Sulfur metabolism_Homo sapiens_hsa009202.27055152
9Selenocompound metabolism_Homo sapiens_hsa004502.24069816
10Nitrogen metabolism_Homo sapiens_hsa009102.19459146
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.19043522
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.05705111
13Protein export_Homo sapiens_hsa030601.95947940
14Linoleic acid metabolism_Homo sapiens_hsa005911.95579609
15RNA polymerase_Homo sapiens_hsa030201.87960213
16Propanoate metabolism_Homo sapiens_hsa006401.87084786
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.78574132
18One carbon pool by folate_Homo sapiens_hsa006701.75018762
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.71461958
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.69391801
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.69239839
22Fanconi anemia pathway_Homo sapiens_hsa034601.69036637
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.66550211
24Tryptophan metabolism_Homo sapiens_hsa003801.64727732
25Ether lipid metabolism_Homo sapiens_hsa005651.58429886
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.58256953
27RNA degradation_Homo sapiens_hsa030181.53256740
28Non-homologous end-joining_Homo sapiens_hsa034501.48842127
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.48263416
30Pentose and glucuronate interconversions_Homo sapiens_hsa000401.47212310
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.44472822
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.42666434
33Retinol metabolism_Homo sapiens_hsa008301.40584442
34Chemical carcinogenesis_Homo sapiens_hsa052041.40524454
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.39451501
36Basal transcription factors_Homo sapiens_hsa030221.35326274
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.33275479
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.29140867
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.26500590
40Nicotine addiction_Homo sapiens_hsa050331.23211122
41Taste transduction_Homo sapiens_hsa047421.20946764
42Insulin secretion_Homo sapiens_hsa049111.15890480
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.13882917
44Glycerolipid metabolism_Homo sapiens_hsa005611.08631494
45Dorso-ventral axis formation_Homo sapiens_hsa043201.06261107
46Circadian rhythm_Homo sapiens_hsa047101.05100910
47Olfactory transduction_Homo sapiens_hsa047400.99358988
48Steroid biosynthesis_Homo sapiens_hsa001000.97400772
49Oxidative phosphorylation_Homo sapiens_hsa001900.96836998
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.95708093
51Fat digestion and absorption_Homo sapiens_hsa049750.91681591
52ABC transporters_Homo sapiens_hsa020100.89494984
53Peroxisome_Homo sapiens_hsa041460.85768944
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81303740
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81123016
56Circadian entrainment_Homo sapiens_hsa047130.76010201
57Purine metabolism_Homo sapiens_hsa002300.75812363
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75742230
59Morphine addiction_Homo sapiens_hsa050320.75473066
60RNA transport_Homo sapiens_hsa030130.73349107
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.70582052
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.70138929
63Nucleotide excision repair_Homo sapiens_hsa034200.68932279
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.68602547
65Starch and sucrose metabolism_Homo sapiens_hsa005000.67430281
66Fatty acid degradation_Homo sapiens_hsa000710.67392570
67beta-Alanine metabolism_Homo sapiens_hsa004100.67166449
68Metabolic pathways_Homo sapiens_hsa011000.64949593
69Glutamatergic synapse_Homo sapiens_hsa047240.63696031
70Ovarian steroidogenesis_Homo sapiens_hsa049130.61030393
71Parkinsons disease_Homo sapiens_hsa050120.60146952
72Regulation of autophagy_Homo sapiens_hsa041400.59522060
73Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58712844
74Serotonergic synapse_Homo sapiens_hsa047260.58482065
75Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.57060863
76Salivary secretion_Homo sapiens_hsa049700.56828432
77Histidine metabolism_Homo sapiens_hsa003400.55720134
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55561315
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54789778
80Arachidonic acid metabolism_Homo sapiens_hsa005900.54391392
81Primary immunodeficiency_Homo sapiens_hsa053400.53004267
82Proteasome_Homo sapiens_hsa030500.51291637
83Vitamin digestion and absorption_Homo sapiens_hsa049770.50571356
84Mineral absorption_Homo sapiens_hsa049780.49336844
85GABAergic synapse_Homo sapiens_hsa047270.49303421
86Calcium signaling pathway_Homo sapiens_hsa040200.46811682
87Collecting duct acid secretion_Homo sapiens_hsa049660.46676002
88Lysine degradation_Homo sapiens_hsa003100.45958116
89Pyrimidine metabolism_Homo sapiens_hsa002400.42126002
90TGF-beta signaling pathway_Homo sapiens_hsa043500.41501052
91Fatty acid metabolism_Homo sapiens_hsa012120.37315048
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.36821316
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35615228
94Hedgehog signaling pathway_Homo sapiens_hsa043400.34458514
95Dopaminergic synapse_Homo sapiens_hsa047280.34445182
96Base excision repair_Homo sapiens_hsa034100.34219329
97Mismatch repair_Homo sapiens_hsa034300.34025204
98Sulfur relay system_Homo sapiens_hsa041220.32404883
99Fatty acid biosynthesis_Homo sapiens_hsa000610.31755643
100N-Glycan biosynthesis_Homo sapiens_hsa005100.31601566

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