NCL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of integrated proviral latency (GO:0075713)6.20759913
2nuclear pore organization (GO:0006999)5.69675635
3nuclear pore complex assembly (GO:0051292)5.65547344
4DNA unwinding involved in DNA replication (GO:0006268)5.15146923
5DNA topological change (GO:0006265)5.14440533
6establishment of viral latency (GO:0019043)4.72703343
7protein localization to kinetochore (GO:0034501)4.67696834
8protein complex localization (GO:0031503)4.67248121
9folic acid-containing compound biosynthetic process (GO:0009396)4.59682984
10mitotic nuclear envelope disassembly (GO:0007077)4.49315473
11IMP biosynthetic process (GO:0006188)4.39374883
12mitotic sister chromatid cohesion (GO:0007064)4.35563518
13ribosome assembly (GO:0042255)4.27880812
14pore complex assembly (GO:0046931)4.24913810
15membrane disassembly (GO:0030397)4.20982973
16nuclear envelope disassembly (GO:0051081)4.20982973
17DNA replication initiation (GO:0006270)4.12431242
18regulation of mRNA stability (GO:0043488)4.12087077
19pre-miRNA processing (GO:0031054)4.06368788
20formation of translation preinitiation complex (GO:0001731)4.03754514
21nucleobase biosynthetic process (GO:0046112)4.01934296
22mitotic metaphase plate congression (GO:0007080)4.00539947
23ATP-dependent chromatin remodeling (GO:0043044)3.92140637
24DNA strand elongation involved in DNA replication (GO:0006271)3.91045158
25IMP metabolic process (GO:0046040)3.89230664
26nucleosome disassembly (GO:0006337)3.89051435
27protein-DNA complex disassembly (GO:0032986)3.89051435
28maturation of SSU-rRNA (GO:0030490)3.88775498
29DNA duplex unwinding (GO:0032508)3.88760500
30DNA geometric change (GO:0032392)3.86989498
31protein localization to chromosome, centromeric region (GO:0071459)3.84411621
32DNA replication-dependent nucleosome organization (GO:0034723)3.83367102
33DNA replication-dependent nucleosome assembly (GO:0006335)3.83367102
34regulation of RNA stability (GO:0043487)3.80183075
35DNA ligation (GO:0006266)3.72191766
36DNA strand elongation (GO:0022616)3.71208258
37cellular protein complex localization (GO:0034629)3.70857748
38heterochromatin organization (GO:0070828)3.69784263
39regulation of translational termination (GO:0006449)3.67611694
40negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.67339556
41mitotic sister chromatid segregation (GO:0000070)3.65710421
42sister chromatid segregation (GO:0000819)3.63984215
43metaphase plate congression (GO:0051310)3.59396942
44kinetochore organization (GO:0051383)3.54582717
45regulation of translational fidelity (GO:0006450)3.53815569
46ribosome biogenesis (GO:0042254)3.53247244
47mitotic chromosome condensation (GO:0007076)3.52347392
48regulation of gene silencing by RNA (GO:0060966)3.49783022
49regulation of posttranscriptional gene silencing (GO:0060147)3.49783022
50regulation of gene silencing by miRNA (GO:0060964)3.49783022
51regulation of spindle organization (GO:0090224)3.48642511
52regulation of RNA export from nucleus (GO:0046831)3.44027343
53histone exchange (GO:0043486)3.44016936
54purine nucleobase biosynthetic process (GO:0009113)3.42383246
55regulation of nucleobase-containing compound transport (GO:0032239)3.41042391
56non-recombinational repair (GO:0000726)3.40901459
57double-strand break repair via nonhomologous end joining (GO:0006303)3.40901459
58negative regulation of histone methylation (GO:0031061)3.40065653
59DNA replication checkpoint (GO:0000076)3.38632105
60telomere maintenance via semi-conservative replication (GO:0032201)3.34565224
61negative regulation of RNA splicing (GO:0033119)3.32784783
62positive regulation of chromosome segregation (GO:0051984)3.32462112
63regulation of mitotic spindle organization (GO:0060236)3.29077675
64termination of RNA polymerase II transcription (GO:0006369)3.27403377
65negative regulation of mRNA processing (GO:0050686)3.27001263
66histone H2B ubiquitination (GO:0033523)3.26582828
67mRNA splice site selection (GO:0006376)3.26349321
68histone arginine methylation (GO:0034969)3.25830672
69chromatin remodeling at centromere (GO:0031055)3.25546353
70nuclear envelope organization (GO:0006998)3.24347367
71ribonucleoprotein complex biogenesis (GO:0022613)3.24303381
72ribosomal large subunit biogenesis (GO:0042273)3.23757285
73regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.23684614
74regulation of histone H3-K9 methylation (GO:0051570)3.22837563
75DNA replication-independent nucleosome assembly (GO:0006336)3.21965631
76DNA replication-independent nucleosome organization (GO:0034724)3.21965631
77RNA splicing, via transesterification reactions (GO:0000375)3.21748219
78mRNA splicing, via spliceosome (GO:0000398)3.21511195
79RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.21511195
80regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.20935787
81dosage compensation (GO:0007549)3.20805188
82regulation of centrosome cycle (GO:0046605)3.18624757
83mitotic recombination (GO:0006312)3.16965347
84establishment of chromosome localization (GO:0051303)3.16094768
85negative regulation of mRNA metabolic process (GO:1903312)3.15869358
86regulation of helicase activity (GO:0051095)3.14042650
87histone H2A monoubiquitination (GO:0035518)3.13842094
88regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.12596945
89alternative mRNA splicing, via spliceosome (GO:0000380)3.12175351
90mRNA stabilization (GO:0048255)3.10676043
91RNA stabilization (GO:0043489)3.10676043
92CENP-A containing nucleosome assembly (GO:0034080)3.09946420
93DNA conformation change (GO:0071103)3.09838044
94chaperone-mediated protein complex assembly (GO:0051131)3.09831226
95regulation of centriole replication (GO:0046599)3.09683163
96peptidyl-arginine omega-N-methylation (GO:0035247)3.09338664
97telomere maintenance via recombination (GO:0000722)3.08122736
98somatic diversification of immune receptors via somatic mutation (GO:0002566)3.07910547
99somatic hypermutation of immunoglobulin genes (GO:0016446)3.07910547
100positive regulation of DNA-templated transcription, elongation (GO:0032786)3.07601777
101cytoplasmic mRNA processing body assembly (GO:0033962)3.06996498
102spliceosomal tri-snRNP complex assembly (GO:0000244)3.06766516
103attachment of spindle microtubules to kinetochore (GO:0008608)3.06757819
104regulation of DNA endoreduplication (GO:0032875)3.05257452
105chromatin assembly or disassembly (GO:0006333)3.04759425
106rRNA processing (GO:0006364)3.03833302
107mRNA transport (GO:0051028)3.03103789
108translational initiation (GO:0006413)3.03068092
109telomere maintenance via telomere lengthening (GO:0010833)3.00549357
110regulation of DNA damage checkpoint (GO:2000001)3.00133273
111peptidyl-arginine methylation (GO:0018216)2.98462517
112peptidyl-arginine N-methylation (GO:0035246)2.98462517
113positive regulation of SMAD protein import into nucleus (GO:0060391)2.98361167
114regulation of sister chromatid cohesion (GO:0007063)2.98356288
115chromatin assembly (GO:0031497)2.98332392
116glucocorticoid receptor signaling pathway (GO:0042921)2.97813187
117translational termination (GO:0006415)2.97583938
118DNA damage response, detection of DNA damage (GO:0042769)2.97447421
119ribosomal small subunit assembly (GO:0000028)2.96840742
120RNA export from nucleus (GO:0006405)2.96570545
121rRNA metabolic process (GO:0016072)2.95927541
122V(D)J recombination (GO:0033151)2.95643877
123ribonucleoprotein complex assembly (GO:0022618)2.94000930
124protein localization to chromosome (GO:0034502)2.92160949
125positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.91702673
126positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.91702673
127positive regulation of mitotic sister chromatid separation (GO:1901970)2.91702673
128nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.91700814
129regulation of chromosome segregation (GO:0051983)2.91631757
130viral transcription (GO:0019083)2.90873306
131mRNA export from nucleus (GO:0006406)2.89816782

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.82175792
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.47185894
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.98202734
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.37057318
5* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.23593480
6* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.19611078
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.18330539
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.78992110
9* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.63476487
10AR_21909140_ChIP-Seq_LNCAP_Human2.44629122
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.43381759
12MYC_22102868_ChIP-Seq_BL_Human2.43081156
13* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.31537079
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.27559260
15* XRN2_22483619_ChIP-Seq_HELA_Human2.26994591
16* E2F1_21310950_ChIP-Seq_MCF-7_Human2.24879715
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.13677639
18E2F7_22180533_ChIP-Seq_HELA_Human10.0074306
19CREB1_15753290_ChIP-ChIP_HEK293T_Human1.98637836
20* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.96471090
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.93056132
22* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.86287028
23KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.86066746
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.83199599
25POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.83182176
26GABP_17652178_ChIP-ChIP_JURKAT_Human1.79699642
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.79529151
28VDR_23849224_ChIP-Seq_CD4+_Human1.79296414
29TTF2_22483619_ChIP-Seq_HELA_Human1.76593402
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.69021970
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.68230429
32FOXP3_21729870_ChIP-Seq_TREG_Human1.65995116
33YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65406276
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.62906699
35CIITA_25753668_ChIP-Seq_RAJI_Human1.62588189
36* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.60013259
37* CLOCK_20551151_ChIP-Seq_293T_Human1.59324327
38KDM5A_27292631_Chip-Seq_BREAST_Human1.58540209
39DCP1A_22483619_ChIP-Seq_HELA_Human1.56851231
40SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.56476779
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56044264
42* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.55594659
43TP63_19390658_ChIP-ChIP_HaCaT_Human1.55588571
44RBPJ_22232070_ChIP-Seq_NCS_Mouse1.55463588
45* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54549178
46ELK1_19687146_ChIP-ChIP_HELA_Human1.51766919
47GABP_19822575_ChIP-Seq_HepG2_Human1.50448354
48POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.47217879
49STAT3_1855785_ChIP-Seq_MESCs_Mouse1.44749444
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37500073
51PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.35916785
52* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35331860
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.35181232
54TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.34749869
55ESR1_15608294_ChIP-ChIP_MCF-7_Human1.31061840
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31049843
57KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29362504
58CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.28511189
59ELF1_17652178_ChIP-ChIP_JURKAT_Human1.28459745
60KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.25130306
61KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.25130306
62KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.25130306
63ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23713381
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20549414
65* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19768307
66SOX2_18555785_ChIP-Seq_MESCs_Mouse1.18408879
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17140003
68FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16417402
69TCF3_18692474_ChIP-Seq_MEFs_Mouse1.16063283
70DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14223830
71E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13607331
72* TFEB_21752829_ChIP-Seq_HELA_Human1.13423981
73* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.12069713
74TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11617921
75* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11384788
76VDR_21846776_ChIP-Seq_THP-1_Human1.07967470
77MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07328273
78HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06062030
79ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.05204171
80* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05185054
81SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04182865
82SOX17_20123909_ChIP-Seq_XEN_Mouse1.02141944
83NANOG_21062744_ChIP-ChIP_HESCs_Human1.01883546
84SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.00912868
85CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98257595
86NOTCH1_21737748_ChIP-Seq_TLL_Human0.98163265
87SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.97398138
88CHD1_26751641_Chip-Seq_LNCaP_Human0.96924499
89NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.95479572
90ZFP281_18757296_ChIP-ChIP_E14_Mouse0.94450314
91* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.92766160
92KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.92340098
93NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.91477298
94* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.91316310
95* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90305240
96YY1_21170310_ChIP-Seq_MESCs_Mouse0.89625965
97KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.89517583
98MYC_18940864_ChIP-ChIP_HL60_Human0.89129767
99SOX2_16153702_ChIP-ChIP_HESCs_Human0.89045186
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88408660
101NANOG_16153702_ChIP-ChIP_HESCs_Human0.88142671
102NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.87324085
103E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.86185308
104* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85805208
105TCF3_18692474_ChIP-Seq_MESCs_Mouse0.84704846
106HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.84460597
107SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.83256024
108ERG_20887958_ChIP-Seq_HPC-7_Mouse0.82948598
109ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.81437143
110HIF1A_21447827_ChIP-Seq_MCF-7_Human0.78176325
111OCT4_18692474_ChIP-Seq_MEFs_Mouse0.78067809
112EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.77834835
113GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.76089886
114ATF3_27146783_Chip-Seq_COLON_Human0.75202290

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.62408497
2MP0010094_abnormal_chromosome_stability4.33627927
3MP0004957_abnormal_blastocyst_morpholog4.14610072
4MP0003111_abnormal_nucleus_morphology4.11307353
5MP0008057_abnormal_DNA_replication3.84520567
6MP0003077_abnormal_cell_cycle3.65431567
7MP0010352_gastrointestinal_tract_polyps3.20072503
8MP0008058_abnormal_DNA_repair2.72194541
9MP0001730_embryonic_growth_arrest2.71771744
10MP0003123_paternal_imprinting2.65800590
11MP0008007_abnormal_cellular_replicative2.59037451
12MP0000350_abnormal_cell_proliferation2.47067380
13MP0002396_abnormal_hematopoietic_system2.36702237
14MP0008932_abnormal_embryonic_tissue2.33991426
15MP0005076_abnormal_cell_differentiation2.31053506
16MP0010307_abnormal_tumor_latency2.21111460
17MP0005380_embryogenesis_phenotype2.08820270
18MP0001672_abnormal_embryogenesis/_devel2.08820270
19MP0004197_abnormal_fetal_growth/weight/2.04000756
20MP0002084_abnormal_developmental_patter2.00078532
21MP0001697_abnormal_embryo_size1.99712379
22MP0008877_abnormal_DNA_methylation1.94653412
23MP0003984_embryonic_growth_retardation1.94504263
24MP0002088_abnormal_embryonic_growth/wei1.91280456
25MP0003705_abnormal_hypodermis_morpholog1.89188559
26MP0002085_abnormal_embryonic_tissue1.85498622
27MP0002086_abnormal_extraembryonic_tissu1.83125056
28MP0003567_abnormal_fetal_cardiomyocyte1.76712129
29MP0002080_prenatal_lethality1.76412178
30MP0003121_genomic_imprinting1.69013821
31MP0002254_reproductive_system_inflammat1.61546847
32MP0003890_abnormal_embryonic-extraembry1.59904774
33MP0004808_abnormal_hematopoietic_stem1.56932010
34MP0000537_abnormal_urethra_morphology1.53153605
35MP0003786_premature_aging1.49430284
36MP0010030_abnormal_orbit_morphology1.47286602
37MP0009053_abnormal_anal_canal1.46957158
38MP0002796_impaired_skin_barrier1.41634300
39MP0000490_abnormal_crypts_of1.41236951
40MP0001293_anophthalmia1.40856596
41MP0000313_abnormal_cell_death1.34617935
42MP0003566_abnormal_cell_adhesion1.26800951
43MP0002019_abnormal_tumor_incidence1.25137993
44MP0003941_abnormal_skin_development1.20692799
45MP0009672_abnormal_birth_weight1.20335637
46MP0001188_hyperpigmentation1.20145342
47MP0003119_abnormal_digestive_system1.16264663
48MP0000703_abnormal_thymus_morphology1.12126198
49MP0002009_preneoplasia1.10291940
50MP0000428_abnormal_craniofacial_morphol1.06749676
51MP0009703_decreased_birth_body1.06562653
52MP0001915_intracranial_hemorrhage1.04619828
53MP0003937_abnormal_limbs/digits/tail_de1.04445694
54MP0005023_abnormal_wound_healing1.03848710
55MP0000579_abnormal_nail_morphology1.00616779
56MP0000733_abnormal_muscle_development0.99251157
57MP0002111_abnormal_tail_morphology0.98143346
58MP0003763_abnormal_thymus_physiology0.97714606
59MP0001849_ear_inflammation0.96861496
60MP0003385_abnormal_body_wall0.96317417
61MP0002210_abnormal_sex_determination0.95706121
62MP0004264_abnormal_extraembryonic_tissu0.92775608
63MP0009697_abnormal_copulation0.91786622
64MP0001299_abnormal_eye_distance/0.91491715
65MP0002697_abnormal_eye_size0.89251633
66MP0001145_abnormal_male_reproductive0.86739045
67MP0003806_abnormal_nucleotide_metabolis0.86519994
68MP0002653_abnormal_ependyma_morphology0.86329332
69MP0002092_abnormal_eye_morphology0.86305120
70MP0010234_abnormal_vibrissa_follicle0.85596103
71MP0005397_hematopoietic_system_phenotyp0.85522690
72MP0001545_abnormal_hematopoietic_system0.85522690
73MP0009333_abnormal_splenocyte_physiolog0.84484739
74MP0002925_abnormal_cardiovascular_devel0.84287595
75MP0002398_abnormal_bone_marrow0.84132090
76MP0002877_abnormal_melanocyte_morpholog0.83778229
77MP0002081_perinatal_lethality0.83622104
78MP0001727_abnormal_embryo_implantation0.82034177
79MP0000762_abnormal_tongue_morphology0.82030965
80MP0000432_abnormal_head_morphology0.80962922
81MP0005621_abnormal_cell_physiology0.80536911
82MP0005384_cellular_phenotype0.79822170
83MP0002722_abnormal_immune_system0.79798752
84MP0009278_abnormal_bone_marrow0.79747520
85MP0001286_abnormal_eye_development0.79720778
86MP0002089_abnormal_postnatal_growth/wei0.79644371
87MP0004272_abnormal_basement_membrane0.77970346
88MP0010630_abnormal_cardiac_muscle0.77758083
89MP0004133_heterotaxia0.77260301
90MP0002060_abnormal_skin_morphology0.76731524
91MP0003115_abnormal_respiratory_system0.76155302
92MP0005623_abnormal_meninges_morphology0.75804806
93MP0006035_abnormal_mitochondrial_morpho0.75803544
94MP0003315_abnormal_perineum_morphology0.74962207
95MP0006054_spinal_hemorrhage0.74612716
96MP0005257_abnormal_intraocular_pressure0.74219863
97MP0003935_abnormal_craniofacial_develop0.72465305
98MP0002233_abnormal_nose_morphology0.72369367
99MP0000477_abnormal_intestine_morphology0.71467123
100MP0004782_abnormal_surfactant_physiolog0.71039516
101MP0000653_abnormal_sex_gland0.70934996
102MP0003718_maternal_effect0.70056125
103MP0004233_abnormal_muscle_weight0.69300929
104MP0000689_abnormal_spleen_morphology0.68823546
105MP0003861_abnormal_nervous_system0.67833288
106MP0008770_decreased_survivor_rate0.67298897
107MP0002114_abnormal_axial_skeleton0.67008572
108MP0000858_altered_metastatic_potential0.66437852
109MP0003221_abnormal_cardiomyocyte_apopto0.64525013
110MP0001929_abnormal_gametogenesis0.62654497
111MP0000266_abnormal_heart_morphology0.61911634
112MP0003755_abnormal_palate_morphology0.60999488
113MP0005501_abnormal_skin_physiology0.60518742
114MP0001177_atelectasis0.59493832
115MP0003787_abnormal_imprinting0.59341130
116MP0000358_abnormal_cell_content/0.59324021
117MP0001346_abnormal_lacrimal_gland0.58900586
118MP0006292_abnormal_olfactory_placode0.58809898
119MP0000566_synostosis0.57699065
120MP0000377_abnormal_hair_follicle0.56809942
121MP0000627_abnormal_mammary_gland0.56809710
122MP0002429_abnormal_blood_cell0.56508582
123MP0003943_abnormal_hepatobiliary_system0.56489632
124MP0004087_abnormal_muscle_fiber0.56116325
125MP0004185_abnormal_adipocyte_glucose0.55439734
126MP0003300_gastrointestinal_ulcer0.55350306
127MP0003448_altered_tumor_morphology0.54974681

Predicted human phenotypes

RankGene SetZ-score
1Spastic diplegia (HP:0001264)4.15589153
2Ependymoma (HP:0002888)4.07001314
3Medulloblastoma (HP:0002885)3.70614555
4Multiple enchondromatosis (HP:0005701)3.56188856
5Selective tooth agenesis (HP:0001592)3.43939096
6Volvulus (HP:0002580)3.42862429
7Birth length less than 3rd percentile (HP:0003561)3.42820986
8Colon cancer (HP:0003003)3.35209789
9Chromsome breakage (HP:0040012)3.27300560
10Proximal placement of thumb (HP:0009623)3.24838322
11Deviation of the thumb (HP:0009603)3.22845884
12Abnormality of the labia minora (HP:0012880)3.19826760
13Cortical dysplasia (HP:0002539)3.14308309
14Reticulocytopenia (HP:0001896)3.05944415
15Increased nuchal translucency (HP:0010880)3.04575142
16Progressive muscle weakness (HP:0003323)2.94675971
17Astrocytoma (HP:0009592)2.93367935
18Abnormality of the astrocytes (HP:0100707)2.93367935
19Abnormal number of incisors (HP:0011064)2.88989560
20Nephroblastoma (Wilms tumor) (HP:0002667)2.86242022
21Rhabdomyosarcoma (HP:0002859)2.85603370
22Chromosomal breakage induced by crosslinking agents (HP:0003221)2.76515903
23Basal cell carcinoma (HP:0002671)2.74675260
24Progressive external ophthalmoplegia (HP:0000590)2.74298450
25Abnormality of chromosome stability (HP:0003220)2.73745029
26Agnosia (HP:0010524)2.72099347
27Insomnia (HP:0100785)2.71721155
28Overriding aorta (HP:0002623)2.67035753
29Embryonal renal neoplasm (HP:0011794)2.65978441
30Neoplasm of the oral cavity (HP:0100649)2.64023312
31Degeneration of anterior horn cells (HP:0002398)2.63565685
32Abnormality of the anterior horn cell (HP:0006802)2.63565685
33Abnormality of the musculature of the pelvis (HP:0001469)2.60613942
34Abnormality of the hip-girdle musculature (HP:0001445)2.60613942
35Patellar aplasia (HP:0006443)2.59049792
36Termporal pattern (HP:0011008)2.57994227
37Insidious onset (HP:0003587)2.57994227
38Biliary tract neoplasm (HP:0100574)2.55449690
39Glioma (HP:0009733)2.55133640
40Breast hypoplasia (HP:0003187)2.52280508
41Absent radius (HP:0003974)2.47855001
42Aplasia/Hypoplasia of the patella (HP:0006498)2.44669902
43Ectopic kidney (HP:0000086)2.44314848
44Hepatoblastoma (HP:0002884)2.40516270
45Back pain (HP:0003418)2.40394478
46Neoplasm of striated muscle (HP:0009728)2.36308286
47Oral leukoplakia (HP:0002745)2.35741933
48Atresia of the external auditory canal (HP:0000413)2.33857152
49Myelodysplasia (HP:0002863)2.33709700
50Amaurosis fugax (HP:0100576)2.31758153
51Missing ribs (HP:0000921)2.31381660
52Abnormality of the preputium (HP:0100587)2.31158881
53Aplasia involving forearm bones (HP:0009822)2.30050782
54Absent forearm bone (HP:0003953)2.30050782
55Meckel diverticulum (HP:0002245)2.29623651
56Long eyelashes (HP:0000527)2.27715810
57Dysmetric saccades (HP:0000641)2.23644010
58Absent thumb (HP:0009777)2.23634750
59Neoplasm of the pancreas (HP:0002894)2.19156597
60Impulsivity (HP:0100710)2.18686770
61Limb-girdle muscle atrophy (HP:0003797)2.17367413
62Prominent nose (HP:0000448)2.16869878
63Elfin facies (HP:0004428)2.16162680
64Abnormality of the ileum (HP:0001549)2.15881087
65Dysphonia (HP:0001618)2.15179216
66Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.15102775
67Short 4th metacarpal (HP:0010044)2.15102775
68Aplasia/Hypoplasia of the uvula (HP:0010293)2.13609130
69Increased density of long bones (HP:0006392)2.13025005
70Abnormality of cells of the erythroid lineage (HP:0012130)2.12441435
71Carpal bone hypoplasia (HP:0001498)2.11878050
72Supernumerary spleens (HP:0009799)2.11263366
73Malignant gastrointestinal tract tumors (HP:0006749)2.09846969
74Gastrointestinal carcinoma (HP:0002672)2.09846969
75Squamous cell carcinoma (HP:0002860)2.04617276
76Pelvic girdle muscle weakness (HP:0003749)2.04299646
77Esophageal atresia (HP:0002032)2.04089413
78Abnormality of the salivary glands (HP:0010286)2.02949435
79Microvesicular hepatic steatosis (HP:0001414)2.02635337
80Obsessive-compulsive behavior (HP:0000722)2.02014390
81Neuroblastic tumors (HP:0004376)2.00439635
82Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.00439635
83Neuroblastoma (HP:0003006)2.00439635
84Primitive neuroectodermal tumor (HP:0030065)2.00439635
85Small intestinal stenosis (HP:0012848)1.99755271
86Duodenal stenosis (HP:0100867)1.99755271
87Cafe-au-lait spot (HP:0000957)1.99429515
88Radioulnar synostosis (HP:0002974)1.99192996
89Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.99043429
90Facial hemangioma (HP:0000329)1.98805345
91Pseudobulbar signs (HP:0002200)1.97066424
92Skull defect (HP:0001362)1.96815944
93Abnormality of abdominal situs (HP:0011620)1.96284581
94Abdominal situs inversus (HP:0003363)1.96284581
95Supernumerary ribs (HP:0005815)1.96261953
96Supernumerary bones of the axial skeleton (HP:0009144)1.95257295
97Aplasia/Hypoplasia of the sternum (HP:0006714)1.95093367
98Unilateral renal agenesis (HP:0000122)1.94891780
99Overlapping toe (HP:0001845)1.93391402
100Hyperacusis (HP:0010780)1.92454314
10111 pairs of ribs (HP:0000878)1.92182933
102Sparse lateral eyebrow (HP:0005338)1.90398621
103Horseshoe kidney (HP:0000085)1.90388282
104Skin tags (HP:0010609)1.89978348
105Aplasia/hypoplasia of the humerus (HP:0006507)1.89401251
106Urethral obstruction (HP:0000796)1.89280100
107Rib fusion (HP:0000902)1.89122300
108Premature graying of hair (HP:0002216)1.88317776
109Facial cleft (HP:0002006)1.88158432
110Calcaneovalgus deformity (HP:0001848)1.87630011
111Trismus (HP:0000211)1.87360733
112Neoplasm of the small intestine (HP:0100833)1.86550033
113Uterine neoplasm (HP:0010784)1.86307122
114High pitched voice (HP:0001620)1.86180864
115Abnormal number of erythroid precursors (HP:0012131)1.86179946
116Tracheoesophageal fistula (HP:0002575)1.86079270
117Deep palmar crease (HP:0006191)1.85873054
118Orthostatic hypotension (HP:0001278)1.85610771
119Vertebral arch anomaly (HP:0008438)1.85461374
120Secondary amenorrhea (HP:0000869)1.85231917
121Renal duplication (HP:0000075)1.84389505
122Preauricular skin tag (HP:0000384)1.84220039
123Cutis marmorata (HP:0000965)1.83910357
124Renovascular hypertension (HP:0100817)1.83388138
125Acute myeloid leukemia (HP:0004808)1.83051680
126Rough bone trabeculation (HP:0100670)1.82914478
127Abnormality of the carotid arteries (HP:0005344)1.82845220
128Blepharitis (HP:0000498)1.82827686
129Sloping forehead (HP:0000340)1.81852260
130Deep philtrum (HP:0002002)1.79546198
131Abnormality of the duodenum (HP:0002246)1.78154545
132Embryonal neoplasm (HP:0002898)1.77940157
133Ovarian neoplasm (HP:0100615)1.76694899
134Sandal gap (HP:0001852)1.76034891
135Gonadotropin excess (HP:0000837)1.75710977
136Abnormality of chromosome segregation (HP:0002916)1.74964974
137Neoplasm of the adrenal cortex (HP:0100641)1.74674172
138High anterior hairline (HP:0009890)1.74087300
139Neoplasm of the colon (HP:0100273)1.73672933
140Abnormality of the calcaneus (HP:0008364)1.71903362
141Low anterior hairline (HP:0000294)1.71630697
142Chronic bronchitis (HP:0004469)1.71576015
143Shoulder girdle muscle weakness (HP:0003547)1.71491480
144Neoplasm of the rectum (HP:0100743)1.70227268
145Arnold-Chiari malformation (HP:0002308)1.69608211
146Transitional cell carcinoma of the bladder (HP:0006740)1.69208912
147Generalized hypotonia (HP:0001290)1.67863017
148Uterine leiomyosarcoma (HP:0002891)1.67171271
149Leiomyosarcoma (HP:0100243)1.67171271
150Long palpebral fissure (HP:0000637)1.66261619
151Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.61958426
152Spina bifida occulta (HP:0003298)1.61432969
153Asymmetry of the thorax (HP:0001555)1.61146264

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.66073393
2CDK123.95554787
3WEE13.43069340
4TSSK63.38173504
5EEF2K2.73603425
6NEK22.61312630
7BUB12.53560481
8SMG12.47682231
9NEK12.40573612
10MKNK12.34524535
11TTK2.33483798
12TNIK2.27614865
13SRPK12.21070442
14EIF2AK12.14913626
15RPS6KB22.14494761
16PASK2.12722359
17BRD42.03173787
18ALK1.93010486
19PLK41.92863334
20TAF11.85990190
21PLK31.80494005
22MKNK21.75982413
23PKN21.73583428
24PNCK1.73287647
25ATR1.73157749
26CDK71.71765524
27PLK11.70485608
28STK101.67251839
29CHEK11.59272867
30CDK41.59181143
31ACVR1B1.55417473
32AURKB1.55325146
33MAP3K81.53295982
34EPHA21.52699705
35TGFBR11.50447819
36RPS6KA41.50295745
37MAP3K101.44950949
38VRK21.43378363
39SCYL21.42766212
40CDK61.35461140
41BRSK21.34393096
42STK241.32427579
43TESK21.22631665
44CHEK21.18881229
45ATM1.16593670
46EIF2AK31.06752732
47* CDK21.05665776
48MTOR1.04466519
49PAK41.03527173
50LATS11.02834130
51MAP3K90.97585789
52CAMK1G0.94795161
53STK30.93074763
54LRRK20.89971069
55PAK20.89860296
56CAMK1D0.87090322
57AURKA0.85249225
58PBK0.84843248
59MAP4K10.84124332
60DYRK30.83001701
61FGFR10.82242954
62PIM10.82162317
63CSNK1E0.81052744
64ERBB40.79735253
65* CDK10.77083956
66LATS20.74621673
67* CSNK2A20.74266125
68TRIB30.73828582
69STK40.72706502
70KDR0.70850522
71CLK10.68832791
72BRSK10.67528851
73NTRK10.65677715
74MELK0.65445054
75NME20.65334865
76FLT30.64657107
77EIF2AK20.63966525
78PRKDC0.61853937
79FGFR40.59814895
80MAP2K30.56804114
81CDK11A0.55919173
82CDK180.52610157
83VRK10.52285916
84YES10.52235614
85CSNK2A10.52161592
86CDK150.51972395
87CDK30.51237975
88RIPK10.51225600
89PAK10.49253549
90BCR0.47043604
91MAP2K20.45713003
92* MAPK140.45633122
93* CSNK1D0.43901691
94AKT20.43617249
95MAP3K130.43342298
96PTK60.43103516
97TTN0.42178175
98ARAF0.41967414
99PRKCI0.41134333
100CDK140.40335184
101TAOK20.39635596
102CHUK0.39613146
103ZAK0.38238900
104BMX0.37874130
105JAK30.37134230
106DMPK0.35260416
107STK38L0.34927916
108TESK10.34782406
109MAPK10.34629550
110PIM20.33564576
111DAPK10.32718616
112AKT10.32306666
113* GSK3B0.32020387
114TAOK10.31740594
115RPS6KA10.31271542
116RPS6KB10.29619251
117ZAP700.29467694
118MAP3K110.29058451
119PDGFRA0.29005343
120CDK80.28774449
121MST40.28460157
122MAPK90.28362289
123ICK0.28180916
124PRPF4B0.27312678
125CDK90.27118378
126PDK20.24997665
127BTK0.24649568
128MAP3K140.23127573
129TLK10.23118953
130MAPK100.22290996
131BRAF0.21805082
132MAPKAPK20.21467768
133MAP3K30.20550091
134RPS6KA50.20347929

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.35612922
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.07725694
3Mismatch repair_Homo sapiens_hsa034303.93077880
4Spliceosome_Homo sapiens_hsa030403.64731478
5RNA transport_Homo sapiens_hsa030133.59399672
6One carbon pool by folate_Homo sapiens_hsa006703.31895503
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.91643720
8Cell cycle_Homo sapiens_hsa041102.83231044
9Nucleotide excision repair_Homo sapiens_hsa034202.57532724
10Base excision repair_Homo sapiens_hsa034102.51809796
11Homologous recombination_Homo sapiens_hsa034402.48363386
12RNA polymerase_Homo sapiens_hsa030202.39413562
13Ribosome_Homo sapiens_hsa030102.37869341
14mRNA surveillance pathway_Homo sapiens_hsa030152.35921020
15Non-homologous end-joining_Homo sapiens_hsa034502.11085181
16RNA degradation_Homo sapiens_hsa030182.09915839
17Fanconi anemia pathway_Homo sapiens_hsa034601.97057910
18Proteasome_Homo sapiens_hsa030501.77043937
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.74107249
20Pyrimidine metabolism_Homo sapiens_hsa002401.72522155
21Basal transcription factors_Homo sapiens_hsa030221.62482887
22p53 signaling pathway_Homo sapiens_hsa041151.58496136
23Antigen processing and presentation_Homo sapiens_hsa046121.33659461
24Epstein-Barr virus infection_Homo sapiens_hsa051691.30975051
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.26962458
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.22846808
27MicroRNAs in cancer_Homo sapiens_hsa052061.20509645
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.19959408
29Viral carcinogenesis_Homo sapiens_hsa052031.19912747
30HTLV-I infection_Homo sapiens_hsa051661.11539157
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.07965851
32Herpes simplex infection_Homo sapiens_hsa051681.07709891
33Thyroid cancer_Homo sapiens_hsa052161.06435769
34Small cell lung cancer_Homo sapiens_hsa052221.04108524
35Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.03128027
36Oocyte meiosis_Homo sapiens_hsa041141.01482698
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.97858663
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.97413381
39Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93462390
40Chronic myeloid leukemia_Homo sapiens_hsa052200.91971730
41Pyruvate metabolism_Homo sapiens_hsa006200.91597370
42Vitamin B6 metabolism_Homo sapiens_hsa007500.88365229
43Hippo signaling pathway_Homo sapiens_hsa043900.88157716
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86427937
45Selenocompound metabolism_Homo sapiens_hsa004500.82504769
46Basal cell carcinoma_Homo sapiens_hsa052170.81519677
47Protein export_Homo sapiens_hsa030600.81129057
48TGF-beta signaling pathway_Homo sapiens_hsa043500.80215991
49Purine metabolism_Homo sapiens_hsa002300.78692896
50Colorectal cancer_Homo sapiens_hsa052100.78667974
51Adherens junction_Homo sapiens_hsa045200.78559004
52Biosynthesis of amino acids_Homo sapiens_hsa012300.77931130
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74786277
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.74230198
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.71727142
56Legionellosis_Homo sapiens_hsa051340.71293799
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.69639194
58Notch signaling pathway_Homo sapiens_hsa043300.68185317
59Lysine degradation_Homo sapiens_hsa003100.66019245
60Viral myocarditis_Homo sapiens_hsa054160.65812429
61Bladder cancer_Homo sapiens_hsa052190.61557412
62Acute myeloid leukemia_Homo sapiens_hsa052210.60727741
63Systemic lupus erythematosus_Homo sapiens_hsa053220.60672769
64mTOR signaling pathway_Homo sapiens_hsa041500.60467363
65NF-kappa B signaling pathway_Homo sapiens_hsa040640.59142274
66Hepatitis B_Homo sapiens_hsa051610.58538609
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57832315
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56969988
69Prostate cancer_Homo sapiens_hsa052150.56641832
70Apoptosis_Homo sapiens_hsa042100.56423912
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55704736
72Pathways in cancer_Homo sapiens_hsa052000.54274457
73Primary immunodeficiency_Homo sapiens_hsa053400.53870963
74Proteoglycans in cancer_Homo sapiens_hsa052050.53528171
75Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50746929
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49671969
77HIF-1 signaling pathway_Homo sapiens_hsa040660.49563240
78Measles_Homo sapiens_hsa051620.49394450
79* Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49064196
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47856710
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46683683
82Hedgehog signaling pathway_Homo sapiens_hsa043400.46203727
83Shigellosis_Homo sapiens_hsa051310.45006275
84Wnt signaling pathway_Homo sapiens_hsa043100.43672129
85T cell receptor signaling pathway_Homo sapiens_hsa046600.43013910
86Tight junction_Homo sapiens_hsa045300.42470207
87Non-small cell lung cancer_Homo sapiens_hsa052230.42147738
88Endometrial cancer_Homo sapiens_hsa052130.41633567
89Pentose phosphate pathway_Homo sapiens_hsa000300.41593384
90Sulfur relay system_Homo sapiens_hsa041220.41116851
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40560061
92Renin-angiotensin system_Homo sapiens_hsa046140.40221211
93Fructose and mannose metabolism_Homo sapiens_hsa000510.38925564
94Pancreatic cancer_Homo sapiens_hsa052120.37925697
95Folate biosynthesis_Homo sapiens_hsa007900.34747261
96Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34289150
97Galactose metabolism_Homo sapiens_hsa000520.33767994
98Arginine and proline metabolism_Homo sapiens_hsa003300.33753871
99Steroid biosynthesis_Homo sapiens_hsa001000.33731017
100Insulin signaling pathway_Homo sapiens_hsa049100.32570933
101Influenza A_Homo sapiens_hsa051640.32353871
102PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31547000
103Type I diabetes mellitus_Homo sapiens_hsa049400.31354083
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.30534693
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29945033
106Melanoma_Homo sapiens_hsa052180.28736939
107AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.28176627
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.27580313
109Drug metabolism - other enzymes_Homo sapiens_hsa009830.27366657
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.25502009
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.24720330
112Thyroid hormone synthesis_Homo sapiens_hsa049180.24539376
113AMPK signaling pathway_Homo sapiens_hsa041520.24419921
114Focal adhesion_Homo sapiens_hsa045100.24095629
115ErbB signaling pathway_Homo sapiens_hsa040120.24001461
116Glucagon signaling pathway_Homo sapiens_hsa049220.23584013
117Toxoplasmosis_Homo sapiens_hsa051450.23446695
118Renal cell carcinoma_Homo sapiens_hsa052110.23419326
119FoxO signaling pathway_Homo sapiens_hsa040680.22672010
120B cell receptor signaling pathway_Homo sapiens_hsa046620.22488902
121Carbon metabolism_Homo sapiens_hsa012000.22095671
122Hematopoietic cell lineage_Homo sapiens_hsa046400.21776009
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.21264478
124Jak-STAT signaling pathway_Homo sapiens_hsa046300.21051020
125Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.19629187
126Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.18933950
127ECM-receptor interaction_Homo sapiens_hsa045120.18689737
128N-Glycan biosynthesis_Homo sapiens_hsa005100.18140173
129Propanoate metabolism_Homo sapiens_hsa006400.16599732
130Estrogen signaling pathway_Homo sapiens_hsa049150.16528702

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