NCKAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.32738115
2locomotory exploration behavior (GO:0035641)5.24826108
3synaptic vesicle maturation (GO:0016188)5.16254720
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.88044607
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.74053724
6glutamate secretion (GO:0014047)4.60809355
7vocalization behavior (GO:0071625)4.57428596
8synaptic vesicle docking involved in exocytosis (GO:0016081)4.54028640
9synaptic vesicle exocytosis (GO:0016079)4.48913796
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.37608636
11regulation of synaptic vesicle exocytosis (GO:2000300)4.34276529
12regulation of glutamate receptor signaling pathway (GO:1900449)4.18943961
13layer formation in cerebral cortex (GO:0021819)4.13775137
14exploration behavior (GO:0035640)4.12070130
15regulation of long-term neuronal synaptic plasticity (GO:0048169)3.99576870
16regulation of neuronal synaptic plasticity (GO:0048168)3.94852970
17ionotropic glutamate receptor signaling pathway (GO:0035235)3.91809552
18protein localization to synapse (GO:0035418)3.88827028
19regulation of synaptic vesicle transport (GO:1902803)3.82851574
20neurotransmitter secretion (GO:0007269)3.73961107
21dendritic spine morphogenesis (GO:0060997)3.71617547
22regulation of synapse structural plasticity (GO:0051823)3.61148798
23neuron cell-cell adhesion (GO:0007158)3.60758673
24neurotransmitter-gated ion channel clustering (GO:0072578)3.60217744
25proline transport (GO:0015824)3.59498698
26regulation of dendritic spine morphogenesis (GO:0061001)3.53730967
27regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.53536076
28paraxial mesoderm development (GO:0048339)3.53393292
29neuronal action potential propagation (GO:0019227)3.53041988
30cellular potassium ion homeostasis (GO:0030007)3.52679242
31synaptic transmission, glutamatergic (GO:0035249)3.51713268
32glutamate receptor signaling pathway (GO:0007215)3.50494939
33activation of protein kinase A activity (GO:0034199)3.46366049
34hemidesmosome assembly (GO:0031581)3.42207162
35desmosome organization (GO:0002934)3.36005940
36neuron-neuron synaptic transmission (GO:0007270)3.34848809
37neuron recognition (GO:0008038)3.33256129
38positive regulation of synapse maturation (GO:0090129)3.31656102
39cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.29280996
40sodium ion export (GO:0071436)3.29261802
41axonal fasciculation (GO:0007413)3.27856631
42long-term memory (GO:0007616)3.27580440
43regulation of synaptic plasticity (GO:0048167)3.26295432
44regulation of excitatory postsynaptic membrane potential (GO:0060079)3.25092875
45innervation (GO:0060384)3.23360698
46membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.21645095
47neuromuscular process controlling balance (GO:0050885)3.20102821
48gamma-aminobutyric acid transport (GO:0015812)3.19544366
49cell communication by electrical coupling (GO:0010644)3.18170034
50dendrite morphogenesis (GO:0048813)3.18140881
51long-term synaptic potentiation (GO:0060291)3.16908067
52vesicle transport along microtubule (GO:0047496)3.16218338
53dendritic spine organization (GO:0097061)3.13004408
54regulation of postsynaptic membrane potential (GO:0060078)3.09183567
55positive regulation of membrane potential (GO:0045838)3.05110112
56positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.99386978
57neurotransmitter transport (GO:0006836)2.94587156
58positive regulation of dendritic spine morphogenesis (GO:0061003)2.91693831
59synaptic vesicle endocytosis (GO:0048488)2.91572861
60chemosensory behavior (GO:0007635)2.90042496
61notochord development (GO:0030903)2.87752679
62auditory behavior (GO:0031223)2.87251762
63establishment of nucleus localization (GO:0040023)2.86901664
64cytoskeletal anchoring at plasma membrane (GO:0007016)2.85822401
65regulation of neurotransmitter secretion (GO:0046928)2.85341708
66bundle of His cell to Purkinje myocyte communication (GO:0086069)2.84058491
67transmission of nerve impulse (GO:0019226)2.83400705
68regulation of dendritic spine development (GO:0060998)2.82210353
69behavioral defense response (GO:0002209)2.80794114
70behavioral fear response (GO:0001662)2.80794114
71regulation of female receptivity (GO:0045924)2.79410410
72regulation of synaptic transmission, glutamatergic (GO:0051966)2.79376607
73G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.78490182
74gamma-aminobutyric acid signaling pathway (GO:0007214)2.77882386
75regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.77287883
76regulation of vesicle fusion (GO:0031338)2.76518652
77organelle transport along microtubule (GO:0072384)2.76324474
78long term synaptic depression (GO:0060292)2.76086089
79nuclear pore complex assembly (GO:0051292)2.75524824
80regulation of clathrin-mediated endocytosis (GO:2000369)2.74731401
81regulation of neurotransmitter levels (GO:0001505)2.71526161
82cerebellar Purkinje cell layer development (GO:0021680)2.67286077
83fear response (GO:0042596)2.67045927
84cerebellar Purkinje cell differentiation (GO:0021702)2.65713349
85synapse organization (GO:0050808)2.65488868
86neuromuscular process (GO:0050905)2.64959890
87postsynaptic membrane organization (GO:0001941)2.64552634
88positive regulation of neurotransmitter secretion (GO:0001956)2.63311379
89mating behavior (GO:0007617)2.63217701
90positive regulation of dendritic spine development (GO:0060999)2.62744802
91positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.62540410
92regulation of neurotransmitter transport (GO:0051588)2.61184951
93response to histamine (GO:0034776)2.60893604
94response to auditory stimulus (GO:0010996)2.60589492
95cellular sodium ion homeostasis (GO:0006883)2.59466854
96suckling behavior (GO:0001967)2.59343446
97regulation of ARF protein signal transduction (GO:0032012)2.58731670
98cell adhesion mediated by integrin (GO:0033627)2.58410946
99learning (GO:0007612)2.58311133
100neuronal ion channel clustering (GO:0045161)2.57861475
101positive regulation of synaptic transmission (GO:0050806)2.57849832
102synapse assembly (GO:0007416)2.57780694
103positive regulation of synaptic transmission, GABAergic (GO:0032230)2.57706960
104membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.57568497
105regulation of synaptic transmission (GO:0050804)2.56930109
106cell communication involved in cardiac conduction (GO:0086065)2.56663630
107detection of calcium ion (GO:0005513)2.56422284
108cerebellar granule cell differentiation (GO:0021707)2.56221325
109hippo signaling (GO:0035329)2.55013987
110regulation of transforming growth factor beta2 production (GO:0032909)2.46853030
111negative regulation of keratinocyte proliferation (GO:0010839)2.43213245
112nuclear pore organization (GO:0006999)2.39680322
113cell-substrate junction assembly (GO:0007044)2.33585385
114negative regulation of hormone biosynthetic process (GO:0032353)2.32854573
115regulation of cardioblast differentiation (GO:0051890)2.27981729
116mitotic sister chromatid cohesion (GO:0007064)2.26968323
117cell migration involved in sprouting angiogenesis (GO:0002042)2.24477129
118chondrocyte proliferation (GO:0035988)2.24266250
119COPII vesicle coating (GO:0048208)2.23300461
120gap junction assembly (GO:0016264)2.21282156
121positive regulation of catenin import into nucleus (GO:0035413)2.20191357
122regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.19265081
123lymphangiogenesis (GO:0001946)2.17712774
124retina vasculature morphogenesis in camera-type eye (GO:0061299)2.15865540
125epithelial cell-cell adhesion (GO:0090136)2.15471704
126embryonic retina morphogenesis in camera-type eye (GO:0060059)2.15468797
127negative regulation of hormone metabolic process (GO:0032351)2.13494762
128planar cell polarity pathway involved in neural tube closure (GO:0090179)2.12222149
129COPI coating of Golgi vesicle (GO:0048205)2.11781228
130Golgi transport vesicle coating (GO:0048200)2.11781228
131adherens junction assembly (GO:0034333)2.07996461
132regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.07380963
133regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.03906415
134plasma membrane repair (GO:0001778)2.02026717
135negative regulation of chondrocyte differentiation (GO:0032331)2.01351571
136polarized epithelial cell differentiation (GO:0030859)1.99578626
137NLS-bearing protein import into nucleus (GO:0006607)1.99133339
138axon extension (GO:0048675)1.99131751
139negative regulation of dendrite morphogenesis (GO:0050774)1.97858523
140myelination in peripheral nervous system (GO:0022011)1.97013318
141peripheral nervous system axon ensheathment (GO:0032292)1.97013318
142* apical protein localization (GO:0045176)1.96416497
143focal adhesion assembly (GO:0048041)1.94334225
144cell-substrate adherens junction assembly (GO:0007045)1.94334225
145regulation of vascular endothelial growth factor signaling pathway (GO:1900746)1.93296866
146cellular protein complex localization (GO:0034629)1.91508209
147Wnt signaling pathway, planar cell polarity pathway (GO:0060071)1.90323078
148potassium ion homeostasis (GO:0055075)1.90092434
149skin morphogenesis (GO:0043589)1.89138939
150endothelial cell morphogenesis (GO:0001886)1.89134616
151regulation of axon extension involved in axon guidance (GO:0048841)1.88912648
152regulation of establishment of planar polarity (GO:0090175)1.88328403
153regulation of catenin import into nucleus (GO:0035412)1.87371050
154* asymmetric protein localization (GO:0008105)1.87007979
155collagen fibril organization (GO:0030199)1.86910728
156establishment of apical/basal cell polarity (GO:0035089)1.86697416
157morphogenesis of an epithelial sheet (GO:0002011)1.85579224
158protein localization to cell surface (GO:0034394)1.85257207
159endodermal cell differentiation (GO:0035987)1.85181676
160vesicle coating (GO:0006901)1.85100095
161neuron projection extension (GO:1990138)1.84536915
162positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)1.83597879
163ventricular cardiac muscle cell action potential (GO:0086005)1.83248059
164artery development (GO:0060840)1.83132514
165regulation of Rac protein signal transduction (GO:0035020)1.82631367
166righting reflex (GO:0060013)1.82193705
167cell-cell junction assembly (GO:0007043)1.81558011
168neuromuscular junction development (GO:0007528)1.81333783
169developmental cell growth (GO:0048588)1.80200528
170establishment of planar polarity (GO:0001736)1.79581494
171establishment of tissue polarity (GO:0007164)1.79581494
172substrate adhesion-dependent cell spreading (GO:0034446)1.79110454
173cell junction assembly (GO:0034329)1.78990065
174regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO1.78950857
175dorsal/ventral axis specification (GO:0009950)1.78530103
176* embryonic foregut morphogenesis (GO:0048617)1.77853687
177regulation of glucocorticoid metabolic process (GO:0031943)1.77577862
178negative regulation of protein localization to cell surface (GO:2000009)1.76575688
179midgut development (GO:0007494)1.76496400
180regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)1.74825714
181cardiac muscle cell action potential (GO:0086001)1.74573746

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.87696809
2GBX2_23144817_ChIP-Seq_PC3_Human3.16485477
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.82005080
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.80751900
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.66283965
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.58856099
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.54361436
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.54361436
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.46164581
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.45353845
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.40046863
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.37458539
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.35386735
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.31735298
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.31639018
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.26427242
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.25877521
18REST_21632747_ChIP-Seq_MESCs_Mouse2.24063378
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.21199564
20DROSHA_22980978_ChIP-Seq_HELA_Human2.16279626
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.11538967
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.08286813
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.00433445
24AR_21909140_ChIP-Seq_LNCAP_Human1.95072549
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.91647441
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.88832343
27WT1_19549856_ChIP-ChIP_CCG9911_Human1.81850098
28REST_18959480_ChIP-ChIP_MESCs_Mouse1.81092559
29SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.79734891
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75492973
31AR_21572438_ChIP-Seq_LNCaP_Human1.70405940
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70226748
33SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.68703665
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.64684351
35PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.64288412
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61996977
37* SMAD4_21799915_ChIP-Seq_A2780_Human1.59274740
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54314913
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.54072970
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.53481933
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.53145920
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50141637
43ZNF274_21170338_ChIP-Seq_K562_Hela1.49517865
44TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.49101542
45CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.47742097
46CTNNB1_20460455_ChIP-Seq_HCT116_Human1.46636163
47* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.41937258
48NR3C1_23031785_ChIP-Seq_PC12_Mouse1.41247783
49SOX2_21211035_ChIP-Seq_LN229_Gbm1.37757323
50* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.37327056
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37303572
52* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.35891106
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.34341469
54IKZF1_21737484_ChIP-ChIP_HCT116_Human1.33224662
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32806082
56* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30340253
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28753873
58NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.28686410
59CLOCK_20551151_ChIP-Seq_293T_Human1.28239779
60STAT3_23295773_ChIP-Seq_U87_Human1.27362168
61AR_19668381_ChIP-Seq_PC3_Human1.26394834
62TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25422307
63* SMAD3_21741376_ChIP-Seq_EPCs_Human1.24553096
64RING1B_27294783_Chip-Seq_ESCs_Mouse1.24425053
65CJUN_26792858_Chip-Seq_BT549_Human1.24375102
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22923184
67TAF15_26573619_Chip-Seq_HEK293_Human1.22893457
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.22621802
69TP53_16413492_ChIP-PET_HCT116_Human1.22353178
70PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.22281888
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21605194
72SMAD_19615063_ChIP-ChIP_OVARY_Human1.21485926
73* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21214164
74STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.20113385
75AR_25329375_ChIP-Seq_VCAP_Human1.19919372
76AHR_22903824_ChIP-Seq_MCF-7_Human1.19869550
77ISL1_27105846_Chip-Seq_CPCs_Mouse1.19195073
78* P300_19829295_ChIP-Seq_ESCs_Human1.19062170
79PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18633697
80ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.17974698
81ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17567651
82FOXM1_26456572_ChIP-Seq_MCF-7_Human1.17417110
83ESR1_21235772_ChIP-Seq_MCF-7_Human1.16590793
84RING1B_27294783_Chip-Seq_NPCs_Mouse1.16089215
85TBX3_20139965_ChIP-Seq_MESCs_Mouse1.15959074
86TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15787113
87* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14984230
88TBX3_20139965_ChIP-Seq_ESCs_Mouse1.14964477
89SOX9_24532713_ChIP-Seq_HFSC_Mouse1.14871262
90* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.13247960
91YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12438008
92KDM2B_26808549_Chip-Seq_K562_Human1.12268245
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10153532
94HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09604388
95RXR_22108803_ChIP-Seq_LS180_Human1.09332956
96RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09129072
97* BRD4_25478319_ChIP-Seq_HGPS_Human1.09059837
98TCF4_18268006_ChIP-ChIP_LS174T_Human1.07919920
99NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06455910
100BCAT_22108803_ChIP-Seq_LS180_Human1.05053133
101CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04673444
102SOX9_26525672_Chip-Seq_HEART_Mouse1.03918724
103EP300_21415370_ChIP-Seq_HL-1_Mouse1.03645689
104TCF4_23295773_ChIP-Seq_U87_Human1.03351966
105ZFP57_27257070_Chip-Seq_ESCs_Mouse1.03101250
106* FUS_26573619_Chip-Seq_HEK293_Human1.02484608
107SMAD3_21741376_ChIP-Seq_HESCs_Human1.02040562
108SMAD4_21741376_ChIP-Seq_HESCs_Human1.02015701
109TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01908082
110EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00570961
111EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.00413803
112ESR2_21235772_ChIP-Seq_MCF-7_Human1.00202433
113SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.99986038
114SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.99986038
115TP53_18474530_ChIP-ChIP_U2OS_Human0.99816818
116* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99272955
117ESR1_20079471_ChIP-ChIP_T-47D_Human0.99233789
118PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97993965
119* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.97701309
120DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97638507
121SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97238377
122* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94964151
123CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94418961
124RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94402435
125NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.94002371
126BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93953144
127SMAD3_21741376_ChIP-Seq_ESCs_Human0.93706753
128RUNX2_22187159_ChIP-Seq_PCA_Human0.93115794
129TRIM28_21343339_ChIP-Seq_HEK293_Human0.93019861
130FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.93002415
131CBX2_27304074_Chip-Seq_ESCs_Mouse0.92778867
132ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92704403
133TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92445214
134SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91803393
135P53_22127205_ChIP-Seq_FIBROBLAST_Human0.91287070
136POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90408499
137NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89928359
138NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89928359
139* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.89440245
140MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88949852
141ZFP281_27345836_Chip-Seq_ESCs_Mouse0.88597957

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.38137176
2MP0003880_abnormal_central_pattern4.01632518
3MP0003635_abnormal_synaptic_transmissio3.79263663
4MP0004270_analgesia3.72012605
5MP0009780_abnormal_chondrocyte_physiolo3.10104704
6MP0002063_abnormal_learning/memory/cond3.09702717
7MP0009745_abnormal_behavioral_response2.91896515
8MP0003941_abnormal_skin_development2.61744488
9MP0002064_seizures2.61191889
10MP0004272_abnormal_basement_membrane2.45876267
11MP0008438_abnormal_cutaneous_collagen2.44258675
12MP0002572_abnormal_emotion/affect_behav2.43066825
13MP0001968_abnormal_touch/_nociception2.37164120
14MP0009046_muscle_twitch2.28549412
15MP0002822_catalepsy2.28105241
16MP0002734_abnormal_mechanical_nocicepti2.26812919
17MP0002909_abnormal_adrenal_gland2.20588595
18MP0010368_abnormal_lymphatic_system2.19146384
19MP0001486_abnormal_startle_reflex2.09946319
20MP0002272_abnormal_nervous_system2.06726464
21MP0010352_gastrointestinal_tract_polyps1.95228629
22MP0003329_amyloid_beta_deposits1.93986607
23MP0000579_abnormal_nail_morphology1.91515876
24MP0005409_darkened_coat_color1.89043267
25MP0005275_abnormal_skin_tensile1.87921521
26MP0001440_abnormal_grooming_behavior1.85765979
27MP0004858_abnormal_nervous_system1.85683293
28MP0001501_abnormal_sleep_pattern1.83154413
29MP0010234_abnormal_vibrissa_follicle1.81108350
30MP0002736_abnormal_nociception_after1.78207260
31MP0005423_abnormal_somatic_nervous1.75819934
32MP0000778_abnormal_nervous_system1.71963505
33MP0002733_abnormal_thermal_nociception1.70959128
34MP0003283_abnormal_digestive_organ1.70353889
35MP0003566_abnormal_cell_adhesion1.65090923
36MP0002735_abnormal_chemical_nociception1.63253405
37MP0004885_abnormal_endolymph1.58124400
38MP0000566_synostosis1.57227651
39MP0004811_abnormal_neuron_physiology1.56627734
40MP0002184_abnormal_innervation1.56590129
41MP0002067_abnormal_sensory_capabilities1.54749165
42MP0001970_abnormal_pain_threshold1.53614567
43MP0002557_abnormal_social/conspecific_i1.49084867
44MP0005646_abnormal_pituitary_gland1.48986113
45MP0000013_abnormal_adipose_tissue1.48982695
46MP0004924_abnormal_behavior1.47787610
47MP0005386_behavior/neurological_phenoty1.47787610
48MP0000955_abnormal_spinal_cord1.45880390
49MP0008569_lethality_at_weaning1.45205588
50MP0000762_abnormal_tongue_morphology1.43512521
51MP0003937_abnormal_limbs/digits/tail_de1.41803196
52MP0000462_abnormal_digestive_system1.40814220
53MP0009053_abnormal_anal_canal1.36901409
54MP0003890_abnormal_embryonic-extraembry1.33698836
55MP0010678_abnormal_skin_adnexa1.29693293
56MP0010030_abnormal_orbit_morphology1.29629030
57MP0003787_abnormal_imprinting1.29287098
58MP0004084_abnormal_cardiac_muscle1.26715768
59MP0003879_abnormal_hair_cell1.24795374
60MP0003950_abnormal_plasma_membrane1.24680017
61MP0005257_abnormal_intraocular_pressure1.23214616
62MP0002882_abnormal_neuron_morphology1.22538454
63MP0003122_maternal_imprinting1.22080760
64MP0002066_abnormal_motor_capabilities/c1.21272317
65MP0003633_abnormal_nervous_system1.20262471
66MP0005187_abnormal_penis_morphology1.20188087
67MP0003385_abnormal_body_wall1.19763304
68MP0001984_abnormal_olfaction1.18504618
69MP0005503_abnormal_tendon_morphology1.15940235
70MP0002837_dystrophic_cardiac_calcinosis1.15532452
71MP0005623_abnormal_meninges_morphology1.15209079
72MP0000383_abnormal_hair_follicle1.13345304
73MP0001879_abnormal_lymphatic_vessel1.13043321
74MP0000428_abnormal_craniofacial_morphol1.07561873
75MP0002697_abnormal_eye_size1.07181554
76MP0002152_abnormal_brain_morphology1.05999996
77MP0001299_abnormal_eye_distance/1.04766033
78MP0001177_atelectasis1.03228795
79MP0006276_abnormal_autonomic_nervous1.03167571
80MP0003942_abnormal_urinary_system1.03114766
81MP0003935_abnormal_craniofacial_develop1.00213611
82MP0000751_myopathy0.99864479
83MP0000467_abnormal_esophagus_morphology0.99318686
84MP0003631_nervous_system_phenotype0.99272207
85MP0004145_abnormal_muscle_electrophysio0.99019453
86MP0002060_abnormal_skin_morphology0.98059976
87MP0002796_impaired_skin_barrier0.97712171
88MP0001502_abnormal_circadian_rhythm0.97543664
89MP0003755_abnormal_palate_morphology0.94947986
90MP0004043_abnormal_pH_regulation0.94071766
91* MP0002084_abnormal_developmental_patter0.93836075
92MP0002234_abnormal_pharynx_morphology0.92369731
93MP0000569_abnormal_digit_pigmentation0.91836057
94MP0004036_abnormal_muscle_relaxation0.91360212
95MP0001958_emphysema0.91172500
96MP0004233_abnormal_muscle_weight0.90264450
97MP0008961_abnormal_basal_metabolism0.90168323
98MP0006138_congestive_heart_failure0.90097181
99MP0009672_abnormal_birth_weight0.89990299
100MP0009384_cardiac_valve_regurgitation0.89532430
101MP0009250_abnormal_appendicular_skeleto0.88774743
102MP0002069_abnormal_eating/drinking_beha0.88666871
103MP0000432_abnormal_head_morphology0.87437822
104MP0004085_abnormal_heartbeat0.87312426
105MP0002108_abnormal_muscle_morphology0.86281565
106MP0010386_abnormal_urinary_bladder0.85446572
107MP0005645_abnormal_hypothalamus_physiol0.84839248
108MP0002233_abnormal_nose_morphology0.83287142
109MP0000537_abnormal_urethra_morphology0.80906300
110MP0000749_muscle_degeneration0.80206096
111MP0003868_abnormal_feces_composition0.79160369
112MP0000631_abnormal_neuroendocrine_gland0.79140477
113MP0009703_decreased_birth_body0.78848052
114MP0004215_abnormal_myocardial_fiber0.78023693
115MP0001188_hyperpigmentation0.76213941
116MP0003632_abnormal_nervous_system0.75915806
117MP0003634_abnormal_glial_cell0.75746587
118MP0000534_abnormal_ureter_morphology0.74466920
119MP0003123_paternal_imprinting0.74392583
120MP0009697_abnormal_copulation0.74196114
121MP0003115_abnormal_respiratory_system0.73291213
122* MP0003119_abnormal_digestive_system0.73058111
123* MP0002085_abnormal_embryonic_tissue0.72669966
124MP0004087_abnormal_muscle_fiber0.72456468
125MP0004484_altered_response_of0.72353663
126MP0005171_absent_coat_pigmentation0.72077669
127MP0000733_abnormal_muscle_development0.71936290
128MP0003690_abnormal_glial_cell0.71599291
129MP0005167_abnormal_blood-brain_barrier0.71139891
130MP0005535_abnormal_body_temperature0.70548422
131MP0004197_abnormal_fetal_growth/weight/0.70213412
132MP0000427_abnormal_hair_cycle0.70124405
133MP0005023_abnormal_wound_healing0.70007373
134MP0001849_ear_inflammation0.69976615
135MP0004130_abnormal_muscle_cell0.69455133
136MP0000604_amyloidosis0.69135261
137MP0002090_abnormal_vision0.68790747
138MP0001529_abnormal_vocalization0.68342273
139MP0002229_neurodegeneration0.68333247
140MP0010630_abnormal_cardiac_muscle0.66855895
141MP0003705_abnormal_hypodermis_morpholog0.66721293
142MP0002896_abnormal_bone_mineralization0.66678758
143MP0002269_muscular_atrophy0.66233460
144MP0000003_abnormal_adipose_tissue0.65166971
145MP0002081_perinatal_lethality0.65086647
146MP0003075_altered_response_to0.64994136
147MP0001672_abnormal_embryogenesis/_devel0.64432276
148MP0005380_embryogenesis_phenotype0.64432276
149MP0008874_decreased_physiological_sensi0.64012059
150MP0005248_abnormal_Harderian_gland0.63722156
151MP0005620_abnormal_muscle_contractility0.63695509
152MP0002876_abnormal_thyroid_physiology0.63531246
153MP0002089_abnormal_postnatal_growth/wei0.63523321
154MP0000647_abnormal_sebaceous_gland0.63361730
155MP0001485_abnormal_pinna_reflex0.63086286
156MP0005501_abnormal_skin_physiology0.62748927
157* MP0003861_abnormal_nervous_system0.61557870
158MP0005499_abnormal_olfactory_system0.61429584
159MP0005394_taste/olfaction_phenotype0.61429584
160MP0001664_abnormal_digestion0.60126246
161MP0002877_abnormal_melanocyte_morpholog0.59409330
162MP0003045_fibrosis0.59401670
163MP0001963_abnormal_hearing_physiology0.59398178
164MP0008872_abnormal_physiological_respon0.58474762

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.01111659
2Myokymia (HP:0002411)5.34904218
3Focal seizures (HP:0007359)4.65993724
4Visual hallucinations (HP:0002367)4.23074736
5Epileptic encephalopathy (HP:0200134)3.70806311
6Atonic seizures (HP:0010819)3.58330008
7Action tremor (HP:0002345)3.55248323
8Absence seizures (HP:0002121)3.36374694
9Progressive cerebellar ataxia (HP:0002073)3.19487969
10Generalized tonic-clonic seizures (HP:0002069)3.08676961
11Premature rupture of membranes (HP:0001788)3.02575104
12Dialeptic seizures (HP:0011146)2.99431335
13Impaired vibration sensation in the lower limbs (HP:0002166)2.94883445
14Protrusio acetabuli (HP:0003179)2.94463368
15Cerebral inclusion bodies (HP:0100314)2.92935440
16Febrile seizures (HP:0002373)2.89499707
17Supranuclear gaze palsy (HP:0000605)2.88534054
18Right ventricular cardiomyopathy (HP:0011663)2.87729794
19Hyperventilation (HP:0002883)2.84888938
20Abnormality of the lower motor neuron (HP:0002366)2.84074952
21Dysdiadochokinesis (HP:0002075)2.79412077
22Poor eye contact (HP:0000817)2.76203602
23Depression (HP:0000716)2.73838092
24Termporal pattern (HP:0011008)2.71428726
25Insidious onset (HP:0003587)2.71428726
26Papilledema (HP:0001085)2.68454301
27Broad-based gait (HP:0002136)2.66582761
28Impaired social interactions (HP:0000735)2.64487328
29Abnormal social behavior (HP:0012433)2.64487328
30Ankle clonus (HP:0011448)2.64414744
31Atrophic scars (HP:0001075)2.62843582
32Amblyopia (HP:0000646)2.62765645
33Drooling (HP:0002307)2.60826984
34Excessive salivation (HP:0003781)2.60826984
35Megalencephaly (HP:0001355)2.56073537
36Neurofibrillary tangles (HP:0002185)2.53818626
37Urinary bladder sphincter dysfunction (HP:0002839)2.52070637
38Dysmetria (HP:0001310)2.51557978
39Arterial tortuosity (HP:0005116)2.49821389
40Vascular tortuosity (HP:0004948)2.48927012
41Truncal ataxia (HP:0002078)2.47808118
42Anxiety (HP:0000739)2.47708692
43Epileptiform EEG discharges (HP:0011182)2.44521685
44Shallow orbits (HP:0000586)2.44511382
45Postural instability (HP:0002172)2.36392433
46Gaze-evoked nystagmus (HP:0000640)2.35736219
47EEG with generalized epileptiform discharges (HP:0011198)2.34159742
48Urinary urgency (HP:0000012)2.34025507
49Torticollis (HP:0000473)2.33162520
50Coronal craniosynostosis (HP:0004440)2.28659389
51Intention tremor (HP:0002080)2.27401076
52Hypsarrhythmia (HP:0002521)2.26131563
53Genetic anticipation (HP:0003743)2.25965695
54Impaired smooth pursuit (HP:0007772)2.22734066
55Ankyloglossia (HP:0010296)2.21063826
56Vertebral arch anomaly (HP:0008438)2.18312892
57Abnormal eating behavior (HP:0100738)2.15060666
58Scanning speech (HP:0002168)2.13097903
59Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.10551538
60Dysmetric saccades (HP:0000641)2.09932912
61Hemiparesis (HP:0001269)2.09413838
62Neonatal short-limb short stature (HP:0008921)2.09051768
63Aplasia involving bones of the upper limbs (HP:0009823)2.07766715
64Aplasia of the phalanges of the hand (HP:0009802)2.07766715
65Aplasia involving bones of the extremities (HP:0009825)2.07766715
66Focal dystonia (HP:0004373)2.07304168
67Broad metatarsal (HP:0001783)2.06413335
68Bronchomalacia (HP:0002780)2.04229778
69Ventricular fibrillation (HP:0001663)2.04007128
70Spastic gait (HP:0002064)2.01894240
71Abnormality of the corticospinal tract (HP:0002492)2.00276475
72Resting tremor (HP:0002322)1.99227769
73Bradykinesia (HP:0002067)1.98282028
74Lower limb muscle weakness (HP:0007340)1.97645137
75Mutism (HP:0002300)1.96608467
76Stereotypic behavior (HP:0000733)1.96372397
77Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.96006357
78Blue irides (HP:0000635)1.94278833
79Ankle contracture (HP:0006466)1.93564514
80Aortic dissection (HP:0002647)1.93184174
81Pheochromocytoma (HP:0002666)1.91963969
82Hemiplegia (HP:0002301)1.91828823
83Impaired vibratory sensation (HP:0002495)1.89730562
84Insomnia (HP:0100785)1.88997950
85Abnormality of ocular smooth pursuit (HP:0000617)1.88526403
86Agitation (HP:0000713)1.87043110
87Macroorchidism (HP:0000053)1.86920831
88Craniofacial dystonia (HP:0012179)1.83703510
89Bladder diverticulum (HP:0000015)1.82808123
90Lower limb asymmetry (HP:0100559)1.82001198
91Status epilepticus (HP:0002133)1.81752577
92Annular pancreas (HP:0001734)1.81410425
93Absent speech (HP:0001344)1.81074208
94Pointed chin (HP:0000307)1.80828954
95Papillary thyroid carcinoma (HP:0002895)1.80082560
96Fragile skin (HP:0001030)1.77838309
97Spinal rigidity (HP:0003306)1.76707893
98Buphthalmos (HP:0000557)1.75000201
99Intellectual disability, profound (HP:0002187)1.73706814
100Bundle branch block (HP:0011710)1.72968790
101Abnormality of binocular vision (HP:0011514)1.72807683
102Diplopia (HP:0000651)1.72807683
103Overgrowth (HP:0001548)1.71729972
104Amyotrophic lateral sclerosis (HP:0007354)1.71721436
105Abnormality of dentin (HP:0010299)1.68890490
106Wormian bones (HP:0002645)1.68697575
107Gait ataxia (HP:0002066)1.66748924
108Obstructive sleep apnea (HP:0002870)1.66114564
109Generalized myoclonic seizures (HP:0002123)1.66081441
110Abnormality of salivation (HP:0100755)1.65976914
111Aortic aneurysm (HP:0004942)1.65619906
112Advanced eruption of teeth (HP:0006288)1.65224682
113Rapidly progressive (HP:0003678)1.64730035
114Hepatoblastoma (HP:0002884)1.64501323
115Mildly elevated creatine phosphokinase (HP:0008180)1.64413919
116Fetal akinesia sequence (HP:0001989)1.64403836
117Aqueductal stenosis (HP:0002410)1.63937011
118Limited hip movement (HP:0008800)1.63841804
119Hypoventilation (HP:0002791)1.63763877
120Turricephaly (HP:0000262)1.63136077
121Bowel diverticulosis (HP:0005222)1.62968639
122Clonus (HP:0002169)1.62741092
123Cutaneous finger syndactyly (HP:0010554)1.60900438
124Pterygium (HP:0001059)1.60282472
125Abnormality of oral frenula (HP:0000190)1.59872421
126Incomplete penetrance (HP:0003829)1.59809062
127Postural tremor (HP:0002174)1.58988423
128Lower limb amyotrophy (HP:0007210)1.58067556
129Ulnar bowing (HP:0003031)1.57397096
130Increased nuchal translucency (HP:0010880)1.55422349
131Soft skin (HP:0000977)1.55317573
132Cardiovascular calcification (HP:0011915)1.54299083
133Microglossia (HP:0000171)1.53733149
134Type 1 muscle fiber predominance (HP:0003803)1.52167425
135Mitral valve prolapse (HP:0001634)1.51870101
136Hammertoe (HP:0001765)1.51110806
137Natal tooth (HP:0000695)1.48747815
138Relative macrocephaly (HP:0004482)1.45581378
139Vertebral clefting (HP:0008428)1.45064747
140Arnold-Chiari malformation (HP:0002308)1.44662214
141Preaxial foot polydactyly (HP:0001841)1.43992043
142Limb-girdle muscle weakness (HP:0003325)1.43198756
143Cutaneous syndactyly (HP:0012725)1.43077993
144Hypoplastic labia majora (HP:0000059)1.42654140
145Pulmonic stenosis (HP:0001642)1.42284012
146Abnormality of molar (HP:0011077)1.40357418
147Abnormality of molar morphology (HP:0011070)1.40357418
148Short nail (HP:0001799)1.40299176
149Asymmetry of the thorax (HP:0001555)1.39388062
150Follicular hyperkeratosis (HP:0007502)1.37932766
151Abnormality of the dental root (HP:0006486)1.35659466
152Taurodontia (HP:0000679)1.35659466
153Abnormality of permanent molar morphology (HP:0011071)1.35659466
154Upper limb amyotrophy (HP:0009129)1.35429547
155Distal upper limb amyotrophy (HP:0007149)1.35429547
156Hyperextensible skin (HP:0000974)1.34452315
157Hyperacusis (HP:0010780)1.34051688
158Cubitus valgus (HP:0002967)1.30849254
159Missing ribs (HP:0000921)1.30433389
160Heterotopia (HP:0002282)1.30269687
161Cervical subluxation (HP:0003308)1.29741296
162Back pain (HP:0003418)1.29458420
163Knee flexion contracture (HP:0006380)1.29294053
164Cerebral aneurysm (HP:0004944)1.27496902
165Abnormality of the labia majora (HP:0012881)1.27473840
166Vascular calcification (HP:0004934)1.27227575
167Osteolytic defects of the phalanges of the hand (HP:0009771)1.27128449
168Osteolytic defects of the hand bones (HP:0009699)1.27128449
169Wide anterior fontanel (HP:0000260)1.26767786
170Ventricular tachycardia (HP:0004756)1.26623065
171Absent eyelashes (HP:0000561)1.26595799
172Abnormality of the distal phalanx of the thumb (HP:0009617)1.25093023
173Abnormality of the ischium (HP:0003174)1.24633049
174Sudden death (HP:0001699)1.24153172
175Spinal cord compression (HP:0002176)1.23807314
176Abnormality of the salivary glands (HP:0010286)1.23288851
177Hypoglycemic seizures (HP:0002173)1.22932545
178Biliary tract neoplasm (HP:0100574)1.22828103

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.32781404
2NTRK34.21486584
3MAP3K93.53752598
4MET2.91248893
5MAP3K42.77793291
6MARK12.69226971
7MINK12.48138359
8KSR22.45297378
9PRKD32.44863628
10MST1R2.27503745
11DAPK22.25527923
12PAK62.15279715
13NTRK12.03891831
14STK38L1.99202949
15MAP3K21.95095558
16KSR11.91164061
17MAP2K71.84378194
18MAP2K41.82426189
19CAMKK11.78433027
20LATS21.67962718
21NTRK21.59655103
22EPHA21.43720358
23RIPK41.43316640
24PLK21.42498017
25TYRO31.40057585
26CDK51.39790226
27STK381.38158141
28TTK1.34510528
29PNCK1.26770534
30PBK1.24867321
31DAPK11.24392153
32TTN1.22743972
33STK391.18289055
34STK31.16294173
35RET1.15641225
36CASK1.14789695
37ERBB41.14718338
38PAK31.13147949
39FER1.12788240
40EEF2K1.12508731
41MAP3K121.09669994
42PRKCG1.06808322
43PDGFRA1.06459976
44EPHB21.06432091
45DDR21.06142427
46GRK51.05272791
47MYLK1.04805410
48PDGFRB1.00603606
49CDK120.99085382
50TSSK60.97967635
51LMTK20.97681364
52CAMKK20.96817725
53PTK2B0.95513221
54FRK0.93137841
55CAMK2A0.92935607
56SCYL20.90277837
57PAK20.88082063
58ARAF0.87527091
59PHKG20.87316544
60PHKG10.87316544
61WEE10.87178478
62RIPK10.87108804
63FGFR10.86657524
64PRPF4B0.86586224
65UHMK10.85958835
66SGK4940.85351439
67SGK2230.85351439
68PRKCH0.84984540
69CAMK2B0.84489229
70TIE10.84121326
71LIMK10.82897899
72TRIB30.82469105
73FGFR20.81806126
74PKN20.80220684
75STK110.77654936
76CDK140.77331278
77TAOK10.77103911
78STK240.76720671
79ERBB30.75817852
80CDK180.75109827
81RAF10.74442352
82CDK150.73494097
83LATS10.73019816
84SGK30.72417622
85SGK20.72335168
86MAPK130.71589348
87BRSK20.70842918
88SIK20.70612745
89MTOR0.70497454
90MAP3K130.70473213
91PAK40.70247871
92NEK90.70219947
93MAP2K10.69888848
94MAP3K10.69492012
95SGK10.68924231
96OXSR10.67386971
97CAMK1G0.66748752
98CSNK1G20.65787861
99CDK190.64941977
100DMPK0.64092253
101ALK0.63750109
102NEK10.62744733
103ROCK10.62129713
104ACVR1B0.62045368
105PDPK10.62024631
106OBSCN0.61471995
107BRSK10.61115425
108AKT30.60867031
109CDC42BPA0.60858847
110CDK11A0.59976157
111ROCK20.59934175
112WNK30.59845100
113PTK20.59393545
114CAMK10.59036801
115NEK60.58521576
116CAMK2G0.57144933
117PDK10.56744362
118BMPR20.56580937
119MAP3K70.55897643
120WNK40.55464760
121INSRR0.53974988
122DYRK1A0.52894593
123PRKCE0.52870428
124WNK10.52583976
125TRPM70.52427556
126MARK20.51523285
127BCR0.50831900
128PINK10.49883537
129TESK10.49546230
130CAMK2D0.49544266
131RPS6KA30.48789225
132PRKCZ0.48721257
133ICK0.45442054
134MAPK100.44787588
135BMX0.44402694
136CSNK1E0.44200369
137PLK30.43690132
138FES0.43199991
139TNIK0.42398101

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.94149039
2Long-term potentiation_Homo sapiens_hsa047202.64688683
3Synaptic vesicle cycle_Homo sapiens_hsa047212.53646018
4Circadian entrainment_Homo sapiens_hsa047132.40915432
5Amphetamine addiction_Homo sapiens_hsa050312.37343251
6GABAergic synapse_Homo sapiens_hsa047272.25685442
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.25450234
8Olfactory transduction_Homo sapiens_hsa047402.24036675
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.22748771
10Glutamatergic synapse_Homo sapiens_hsa047242.22698493
11ECM-receptor interaction_Homo sapiens_hsa045122.05390154
12Insulin secretion_Homo sapiens_hsa049112.04052566
13Salivary secretion_Homo sapiens_hsa049702.01839912
14Dopaminergic synapse_Homo sapiens_hsa047282.01102455
15Nitrogen metabolism_Homo sapiens_hsa009102.00446120
16Morphine addiction_Homo sapiens_hsa050321.99109131
17Gastric acid secretion_Homo sapiens_hsa049711.83645712
18Adherens junction_Homo sapiens_hsa045201.77433134
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.75970300
20Cholinergic synapse_Homo sapiens_hsa047251.69137352
21Renin secretion_Homo sapiens_hsa049241.67894553
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58722591
23Long-term depression_Homo sapiens_hsa047301.57925042
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.56556270
25Oxytocin signaling pathway_Homo sapiens_hsa049211.52139470
26Cocaine addiction_Homo sapiens_hsa050301.50432414
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.47648520
28GnRH signaling pathway_Homo sapiens_hsa049121.47393830
29Taste transduction_Homo sapiens_hsa047421.45430780
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.39822294
31Gap junction_Homo sapiens_hsa045401.39163703
32Vitamin B6 metabolism_Homo sapiens_hsa007501.35953491
33Serotonergic synapse_Homo sapiens_hsa047261.32825237
34Calcium signaling pathway_Homo sapiens_hsa040201.32075822
35Glioma_Homo sapiens_hsa052141.29236177
36Type II diabetes mellitus_Homo sapiens_hsa049301.28490313
37Estrogen signaling pathway_Homo sapiens_hsa049151.27632478
38Melanogenesis_Homo sapiens_hsa049161.20388112
39cAMP signaling pathway_Homo sapiens_hsa040241.19490121
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.18173786
41Axon guidance_Homo sapiens_hsa043601.15791187
42TGF-beta signaling pathway_Homo sapiens_hsa043501.13626209
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.09157758
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09085621
45Protein digestion and absorption_Homo sapiens_hsa049741.08161943
46Dorso-ventral axis formation_Homo sapiens_hsa043201.07960431
47Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05321654
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.03745475
49Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.02631238
50Thyroid hormone synthesis_Homo sapiens_hsa049181.00730370
51Basal cell carcinoma_Homo sapiens_hsa052171.00493982
52ErbB signaling pathway_Homo sapiens_hsa040121.00222965
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.96622634
54Thyroid cancer_Homo sapiens_hsa052160.95028954
55Pancreatic secretion_Homo sapiens_hsa049720.93203018
56Collecting duct acid secretion_Homo sapiens_hsa049660.92454020
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90591408
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89629307
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89240064
60Oocyte meiosis_Homo sapiens_hsa041140.89123485
61Bile secretion_Homo sapiens_hsa049760.88338475
62Glucagon signaling pathway_Homo sapiens_hsa049220.87530663
63MicroRNAs in cancer_Homo sapiens_hsa052060.87293110
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83807156
65mTOR signaling pathway_Homo sapiens_hsa041500.82581763
66Vibrio cholerae infection_Homo sapiens_hsa051100.81417246
67Dilated cardiomyopathy_Homo sapiens_hsa054140.80215458
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.76807129
69Choline metabolism in cancer_Homo sapiens_hsa052310.74647339
70Small cell lung cancer_Homo sapiens_hsa052220.74355639
71* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73562920
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72883017
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72191180
74VEGF signaling pathway_Homo sapiens_hsa043700.72053161
75Melanoma_Homo sapiens_hsa052180.69945825
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68523203
77Arginine and proline metabolism_Homo sapiens_hsa003300.67628789
78Endometrial cancer_Homo sapiens_hsa052130.66752008
79Lysine degradation_Homo sapiens_hsa003100.66230268
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66164433
81Pyruvate metabolism_Homo sapiens_hsa006200.64533288
82Propanoate metabolism_Homo sapiens_hsa006400.64018067
83Rap1 signaling pathway_Homo sapiens_hsa040150.63294882
84PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63075945
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62366439
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61746538
87Amoebiasis_Homo sapiens_hsa051460.61483428
88Cell cycle_Homo sapiens_hsa041100.60764303
892-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60713529
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59563049
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.59529182
92Fatty acid metabolism_Homo sapiens_hsa012120.58653856
93MAPK signaling pathway_Homo sapiens_hsa040100.58116653
94Arginine biosynthesis_Homo sapiens_hsa002200.57742939
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57661606
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57423194
97Steroid biosynthesis_Homo sapiens_hsa001000.56793637
98Insulin signaling pathway_Homo sapiens_hsa049100.56781436
99Wnt signaling pathway_Homo sapiens_hsa043100.56493089
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55313323
101Tight junction_Homo sapiens_hsa045300.55210918
102Ras signaling pathway_Homo sapiens_hsa040140.55146248
103Renal cell carcinoma_Homo sapiens_hsa052110.54223267
104Cardiac muscle contraction_Homo sapiens_hsa042600.53832275
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53237174
106Pathways in cancer_Homo sapiens_hsa052000.52970667
107Prion diseases_Homo sapiens_hsa050200.52672079
108Circadian rhythm_Homo sapiens_hsa047100.49830807
109Fatty acid biosynthesis_Homo sapiens_hsa000610.48596618
110Non-small cell lung cancer_Homo sapiens_hsa052230.48447388
111Butanoate metabolism_Homo sapiens_hsa006500.48402742
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47849052
113Ovarian steroidogenesis_Homo sapiens_hsa049130.46991887
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45862041
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.45139701
116Hippo signaling pathway_Homo sapiens_hsa043900.44481428
117Inositol phosphate metabolism_Homo sapiens_hsa005620.44320989
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43441935
119Endocytosis_Homo sapiens_hsa041440.41886707
120Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40705535
121Focal adhesion_Homo sapiens_hsa045100.40306965
122Phototransduction_Homo sapiens_hsa047440.40169710
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.38486624
124Hedgehog signaling pathway_Homo sapiens_hsa043400.38408430
125Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36932953
126AMPK signaling pathway_Homo sapiens_hsa041520.36033681
127Proteoglycans in cancer_Homo sapiens_hsa052050.35921611
128Alcoholism_Homo sapiens_hsa050340.34887176
129Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33695456

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