NCF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)6.01921963
2modulation by symbiont of host immune response (GO:0052553)5.81160573
3positive regulation by symbiont of host defense response (GO:0052509)5.81160573
4modulation by symbiont of host defense response (GO:0052031)5.81160573
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.81160573
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.81160573
7positive regulation by organism of defense response of other organism involved in symbiotic interact5.81160573
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.61304880
9response to peptidoglycan (GO:0032494)5.30646926
10regulation of B cell receptor signaling pathway (GO:0050855)4.71128125
11regulation of interferon-beta biosynthetic process (GO:0045357)4.67932002
12positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.64108318
13neutrophil activation (GO:0042119)4.62651970
14macrophage activation involved in immune response (GO:0002281)4.60632377
15detection of bacterium (GO:0016045)4.59718738
16detection of external biotic stimulus (GO:0098581)4.59492419
17* respiratory burst (GO:0045730)4.57250901
18neutrophil mediated immunity (GO:0002446)4.50786626
19immunoglobulin mediated immune response (GO:0016064)4.50136267
20granulocyte activation (GO:0036230)4.49138748
21leukocyte aggregation (GO:0070486)4.35197443
22cellular extravasation (GO:0045123)4.34909505
23response to host immune response (GO:0052572)4.23721642
24response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.23721642
25production of molecular mediator involved in inflammatory response (GO:0002532)4.18854110
26positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.17230999
27regulation of gamma-delta T cell activation (GO:0046643)4.11956857
28detection of biotic stimulus (GO:0009595)4.06660122
29regulation of mast cell degranulation (GO:0043304)4.00651918
30myeloid cell activation involved in immune response (GO:0002275)3.98549630
31positive regulation of gamma-delta T cell activation (GO:0046645)3.97814711
32positive regulation of interferon-alpha production (GO:0032727)3.90208670
33regulation of mast cell activation (GO:0033003)3.90047205
34positive regulation of B cell differentiation (GO:0045579)3.86913916
35response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.86706669
36response to host (GO:0075136)3.86706669
37response to host defenses (GO:0052200)3.86706669
38positive regulation of mast cell activation (GO:0033005)3.86176722
39positive regulation of antigen processing and presentation (GO:0002579)3.85503896
40negative regulation of lymphocyte mediated immunity (GO:0002707)3.85383991
41regulation of mast cell activation involved in immune response (GO:0033006)3.75850964
42regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.74154676
43response to muramyl dipeptide (GO:0032495)3.73755605
44regulation of interferon-alpha production (GO:0032647)3.69026755
45microglial cell activation (GO:0001774)3.66455122
46positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.62483250
47positive regulation of mast cell activation involved in immune response (GO:0033008)3.62374504
48positive regulation of mast cell degranulation (GO:0043306)3.62374504
49negative regulation of T cell mediated immunity (GO:0002710)3.54705616
50response to fungus (GO:0009620)3.51292661
51Arp2/3 complex-mediated actin nucleation (GO:0034314)3.51141422
52myeloid leukocyte mediated immunity (GO:0002444)3.49060962
53B cell receptor signaling pathway (GO:0050853)3.47006829
54cellular response to type I interferon (GO:0071357)3.46788637
55type I interferon signaling pathway (GO:0060337)3.46788637
56reactive oxygen species biosynthetic process (GO:1903409)3.44739161
57negative regulation of leukocyte mediated immunity (GO:0002704)3.43518595
58response to type I interferon (GO:0034340)3.43364651
59regulation of B cell differentiation (GO:0045577)3.42705313
60regulation of gamma-delta T cell differentiation (GO:0045586)3.41659431
61hydrogen peroxide biosynthetic process (GO:0050665)3.41417663
62negative regulation of phagocytosis (GO:0050765)3.39066713
63leukocyte mediated cytotoxicity (GO:0001909)3.38938385
64macrophage activation (GO:0042116)3.38673411
65defense response to protozoan (GO:0042832)3.37559453
66antigen processing and presentation of endogenous antigen (GO:0019883)3.35658637
67regulation of myeloid leukocyte mediated immunity (GO:0002886)3.35130150
68B cell mediated immunity (GO:0019724)3.34027375
69cellular response to zinc ion (GO:0071294)3.33882856
70negative regulation of mast cell activation (GO:0033004)3.33416666
71regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.32569345
72regulation of leukocyte degranulation (GO:0043300)3.31882737
73regulation of antigen processing and presentation (GO:0002577)3.31723545
74lipopolysaccharide-mediated signaling pathway (GO:0031663)3.31154488
75response to interleukin-15 (GO:0070672)3.29145552
76leukocyte migration involved in inflammatory response (GO:0002523)3.26727495
77pinocytosis (GO:0006907)3.26061818
78neutrophil chemotaxis (GO:0030593)3.25101653
79myeloid dendritic cell activation (GO:0001773)3.22979258
80antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.20466263
81antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.20466263
82regulation of tolerance induction (GO:0002643)3.19895034
83regulation of T cell tolerance induction (GO:0002664)3.19814537
84regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.19808546
85negative regulation of interleukin-12 production (GO:0032695)3.18597765
86* superoxide anion generation (GO:0042554)3.16202945
87neutrophil migration (GO:1990266)3.15406504
88myeloid leukocyte activation (GO:0002274)3.14692946
89regulation of T-helper 2 cell differentiation (GO:0045628)3.10902551
90T-helper 1 type immune response (GO:0042088)3.10543825
91positive regulation of cellular amide metabolic process (GO:0034250)3.10155319
92response to protozoan (GO:0001562)3.07992023
93antigen processing and presentation via MHC class Ib (GO:0002475)3.07155298
94leukocyte degranulation (GO:0043299)3.06263802
95regulation of interleukin-8 biosynthetic process (GO:0045414)3.06096325
96regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.05021251
97negative regulation of granulocyte differentiation (GO:0030853)3.02808743
98detection of molecule of bacterial origin (GO:0032490)3.02348795
99regulation of dendritic cell antigen processing and presentation (GO:0002604)3.01415594
100leukotriene metabolic process (GO:0006691)3.00677527
101negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.99053361
102negative regulation of cell killing (GO:0031342)2.99053361
103positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.97960186
104interferon-gamma-mediated signaling pathway (GO:0060333)2.96605361
105myeloid dendritic cell differentiation (GO:0043011)2.96344133
106detection of other organism (GO:0098543)2.94909201
107negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.94615965
108positive regulation of interferon-beta production (GO:0032728)2.94414594
109cellular response to interleukin-15 (GO:0071350)2.94091096
110negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.93026987
111modulation of growth of symbiont involved in interaction with host (GO:0044144)2.91609731
112regulation of growth of symbiont in host (GO:0044126)2.91609731
113negative regulation of growth of symbiont in host (GO:0044130)2.91609731
114negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.91609731
115germinal center formation (GO:0002467)2.91566389
116positive regulation of toll-like receptor signaling pathway (GO:0034123)2.91293393
117mast cell activation (GO:0045576)2.89521881
118negative regulation of cytokine production involved in immune response (GO:0002719)2.89086397
119natural killer cell mediated immunity (GO:0002228)2.87631581
120natural killer cell mediated cytotoxicity (GO:0042267)2.87631581
121T cell migration (GO:0072678)2.87089639
122negative regulation of erythrocyte differentiation (GO:0045647)2.86130385
123negative regulation of interleukin-17 production (GO:0032700)2.85728948
124positive regulation of type 2 immune response (GO:0002830)2.84794688
125dendritic cell migration (GO:0036336)2.84082816
126regulation of regulated secretory pathway (GO:1903305)2.84047638
127actin nucleation (GO:0045010)2.83731842
128positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.80484108
129regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.80170429
130granulocyte chemotaxis (GO:0071621)2.79438962
131leukocyte cell-cell adhesion (GO:0007159)2.79210897
132positive regulation of leukocyte degranulation (GO:0043302)2.78272501

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse6.12681684
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.98975745
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.60470547
4* IRF8_27001747_Chip-Seq_BMDM_Mouse4.27133424
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.16658957
6* MECOM_23826213_ChIP-Seq_KASUMI_Mouse4.10343982
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.66348264
8* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.62126400
9* MYB_21317192_ChIP-Seq_ERMYB_Mouse3.61059425
10EGR1_19374776_ChIP-ChIP_THP-1_Human3.36614522
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.32539131
12* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.18350104
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.16586047
14Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.16205104
15E2F7_22180533_ChIP-Seq_HELA_Human3.07952834
16SCL_19346495_ChIP-Seq_HPC-7_Human2.87776308
17* SPI1_23547873_ChIP-Seq_NB4_Human2.82127922
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.73901877
19* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.57283035
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.56699673
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.52905521
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.41420712
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.40074210
24VDR_21846776_ChIP-Seq_THP-1_Human2.32066795
25* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.30724902
26VDR_24763502_ChIP-Seq_THP-1_Human2.22641259
27* RUNX1_22412390_ChIP-Seq_EML_Mouse2.09820601
28SPI1_23127762_ChIP-Seq_K562_Human2.03562071
29ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.03098058
30MYB_26560356_Chip-Seq_TH2_Human2.01224715
31MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.97468029
32* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.96924595
33RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.95689863
34* PU_27001747_Chip-Seq_BMDM_Mouse1.88761901
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.88428451
36PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.85594552
37RUNX_20019798_ChIP-Seq_JUKART_Human1.84771757
38MAF_26560356_Chip-Seq_TH1_Human1.82176039
39MYB_26560356_Chip-Seq_TH1_Human1.73911174
40LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.72192476
41CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.68630536
42* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.59228251
43LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.55279964
44CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.52711282
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52553506
46PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.52520511
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.50090351
48STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.48642798
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.46472383
50GATA2_22383799_ChIP-Seq_G1ME_Mouse1.46419038
51MYC_22102868_ChIP-Seq_BL_Human1.45295792
52* VDR_24787735_ChIP-Seq_THP-1_Human1.41687470
53UTX_26944678_Chip-Seq_JUKART_Human1.41538256
54KDM2B_26808549_Chip-Seq_DND41_Human1.40874279
55STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.38595454
56ELF1_17652178_ChIP-ChIP_JURKAT_Human1.36112776
57FOXM1_23109430_ChIP-Seq_U2OS_Human1.35507010
58TCF7_22412390_ChIP-Seq_EML_Mouse1.33483483
59CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31477359
60SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29271277
61CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29232436
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.28955148
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26711758
64* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.26269575
65PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22917361
66GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21962996
67GATA3_27048872_Chip-Seq_THYMUS_Human1.20993317
68GATA2_21666600_ChIP-Seq_HMVEC_Human1.17686031
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.17476986
70CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.17388673
71NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.17029224
72PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16942854
73STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16692895
74* GATA3_26560356_Chip-Seq_TH2_Human1.15820700
75GATA1_22025678_ChIP-Seq_K562_Human1.15447197
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14440036
77GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.14144179
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09557032
79GATA1_19941827_ChIP-Seq_MEL_Mouse1.08504111
80TFEB_21752829_ChIP-Seq_HELA_Human1.04200055
81SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.03230636
82TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01440896
83VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97936399
84MAF_26560356_Chip-Seq_TH2_Human0.94528992
85KDM2B_26808549_Chip-Seq_JURKAT_Human0.94443635
86LXR_22292898_ChIP-Seq_THP-1_Human0.91958874
87TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87280470
88PU.1_20513432_ChIP-Seq_Bcells_Mouse0.83044058
89BCL6_27268052_Chip-Seq_Bcells_Human0.82302133
90E2F4_17652178_ChIP-ChIP_JURKAT_Human0.81410612
91GATA1_19941827_ChIP-Seq_MEL86_Mouse0.81117931
92BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.80152166
93THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.78909399
94* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78000059
95ELK3_25401928_ChIP-Seq_HUVEC_Human0.76169733
96SPI1_20517297_ChIP-Seq_HL60_Human0.75875184
97RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.74088853
98GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73719287
99* BCOR_27268052_Chip-Seq_Bcells_Human0.72790870
100SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72233963
101GATA2_19941826_ChIP-Seq_K562_Human0.72207030
102* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71086975
103ETS1_22383799_ChIP-Seq_G1ME_Mouse0.69825787
104KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.68845465
105KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.64512383
106KDM2B_26808549_Chip-Seq_SUP-B15_Human0.63839415
107FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.58499903
108SMAD_19615063_ChIP-ChIP_OVARY_Human0.58477279
109GATA1_19941826_ChIP-Seq_K562_Human0.57280179
110STAT1_20625510_ChIP-Seq_HELA_Human0.55886607
111NCOR1_26117541_ChIP-Seq_K562_Human0.55710093
112IKZF1_21737484_ChIP-ChIP_HCT116_Human0.55675791

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.46773313
2MP0003436_decreased_susceptibility_to3.82754700
3MP0003303_peritoneal_inflammation3.72207741
4MP0002419_abnormal_innate_immunity3.36989906
5MP0009785_altered_susceptibility_to3.19694483
6MP0002148_abnormal_hypersensitivity_rea3.06026424
7MP0005000_abnormal_immune_tolerance2.98185895
8MP0005058_abnormal_lysosome_morphology2.91433593
9MP0005025_abnormal_response_to2.86192264
10MP0002452_abnormal_antigen_presenting2.80849115
11MP0005387_immune_system_phenotype2.72839644
12MP0001790_abnormal_immune_system2.72839644
13MP0001800_abnormal_humoral_immune2.71107600
14MP0000685_abnormal_immune_system2.62120986
15MP0005671_abnormal_response_to2.59007771
16MP0002723_abnormal_immune_serum2.51282096
17MP0005464_abnormal_platelet_physiology2.50477123
18MP0001819_abnormal_immune_cell2.44763821
19MP0002420_abnormal_adaptive_immunity2.44415489
20MP0006082_CNS_inflammation2.43217613
21MP0003724_increased_susceptibility_to2.40629210
22MP0003172_abnormal_lysosome_physiology2.28030845
23MP0000569_abnormal_digit_pigmentation2.19190493
24MP0005174_abnormal_tail_pigmentation2.06980075
25MP0003183_abnormal_peptide_metabolism2.06105510
26MP0002405_respiratory_system_inflammati2.05089116
27MP0001853_heart_inflammation2.02041415
28MP0001533_abnormal_skeleton_physiology1.98396650
29MP0005451_abnormal_body_composition1.93969605
30MP0009278_abnormal_bone_marrow1.92940362
31MP0000716_abnormal_immune_system1.86240427
32MP0002398_abnormal_bone_marrow1.84842684
33MP0004510_myositis1.84725810
34MP0001845_abnormal_inflammatory_respons1.83704565
35MP0002396_abnormal_hematopoietic_system1.82284634
36MP0003191_abnormal_cellular_cholesterol1.78226956
37MP0005397_hematopoietic_system_phenotyp1.67767632
38MP0001545_abnormal_hematopoietic_system1.67767632
39MP0000343_altered_response_to1.66460334
40MP0000689_abnormal_spleen_morphology1.62570377
41MP0010155_abnormal_intestine_physiology1.62441683
42MP0000465_gastrointestinal_hemorrhage1.60995815
43MP0002429_abnormal_blood_cell1.55654526
44MP0003300_gastrointestinal_ulcer1.52286207
45MP0000015_abnormal_ear_pigmentation1.51347888
46MP0008469_abnormal_protein_level1.48822761
47MP0009333_abnormal_splenocyte_physiolog1.48569701
48MP0002722_abnormal_immune_system1.47892976
49MP0002166_altered_tumor_susceptibility1.47143412
50MP0004947_skin_inflammation1.46084867
51MP0004808_abnormal_hematopoietic_stem1.45514958
52MP0005310_abnormal_salivary_gland1.45512220
53MP0003448_altered_tumor_morphology1.43859226
54MP0002006_tumorigenesis1.43231020
55MP0009764_decreased_sensitivity_to1.43025859
56MP0003075_altered_response_to1.41105486
57MP0000858_altered_metastatic_potential1.37962063
58MP0001873_stomach_inflammation1.32032019
59MP0003828_pulmonary_edema1.27298647
60MP0001851_eye_inflammation1.27127148
61MP0000490_abnormal_crypts_of1.24605774
62MP0002998_abnormal_bone_remodeling1.20967292
63MP0010307_abnormal_tumor_latency1.20434594
64MP0002138_abnormal_hepatobiliary_system1.15986587
65MP0002277_abnormal_respiratory_mucosa1.14066172
66MP0005166_decreased_susceptibility_to1.12803470
67MP0004381_abnormal_hair_follicle1.12423928
68MP0008004_abnormal_stomach_pH1.09061609
69MP0002933_joint_inflammation1.08171455
70MP0009840_abnormal_foam_cell1.06959946
71MP0003763_abnormal_thymus_physiology1.04608664
72MP0008260_abnormal_autophagy0.95144589
73MP0003690_abnormal_glial_cell0.93741778
74MP0005390_skeleton_phenotype0.93181693
75MP0003806_abnormal_nucleotide_metabolis0.92418001
76MP0000371_diluted_coat_color0.92061755
77MP0000703_abnormal_thymus_morphology0.88362709
78MP0003866_abnormal_defecation0.86187618
79MP0002095_abnormal_skin_pigmentation0.85049202
80MP0004782_abnormal_surfactant_physiolog0.84261571
81MP0003566_abnormal_cell_adhesion0.84101835
82MP0002332_abnormal_exercise_endurance0.82730111
83MP0009763_increased_sensitivity_to0.81000792
84MP0003656_abnormal_erythrocyte_physiolo0.79310097
85MP0005076_abnormal_cell_differentiation0.77588806
86MP0001663_abnormal_digestive_system0.77460297
87MP0005164_abnormal_response_to0.77282121
88MP0005167_abnormal_blood-brain_barrier0.76187767
89MP0000604_amyloidosis0.75874329
90MP0000249_abnormal_blood_vessel0.75082572
91MP0003329_amyloid_beta_deposits0.74946962
92MP0003221_abnormal_cardiomyocyte_apopto0.74019571
93MP0005075_abnormal_melanosome_morpholog0.73481193
94MP0009765_abnormal_xenobiotic_induced0.72634688
95MP0003091_abnormal_cell_migration0.72106315
96MP0008874_decreased_physiological_sensi0.69796530
97MP0006054_spinal_hemorrhage0.69542309
98MP0004883_abnormal_blood_vessel0.67590368
99MP0000920_abnormal_myelination0.67378825
100MP0002132_abnormal_respiratory_system0.66898872
101MP0003045_fibrosis0.66666452
102MP0003795_abnormal_bone_structure0.66176695
103MP0002019_abnormal_tumor_incidence0.66154391
104MP0003186_abnormal_redox_activity0.64051646
105MP0008057_abnormal_DNA_replication0.60252983
106MP0001986_abnormal_taste_sensitivity0.58445985
107MP0000767_abnormal_smooth_muscle0.56068455
108MP0004130_abnormal_muscle_cell0.55702099
109MP0003693_abnormal_embryo_hatching0.54790887
110MP0005319_abnormal_enzyme/_coenzyme0.53207881
111MP0002136_abnormal_kidney_physiology0.50955195
112MP0003453_abnormal_keratinocyte_physiol0.50548668
113MP0001958_emphysema0.49159632
114MP0002133_abnormal_respiratory_system0.48809992
115MP0003279_aneurysm0.46536051
116MP0002254_reproductive_system_inflammat0.46433600
117MP0008873_increased_physiological_sensi0.45861823

Predicted human phenotypes

RankGene SetZ-score
1* Recurrent abscess formation (HP:0002722)7.44755693
2* Recurrent bacterial skin infections (HP:0005406)6.53801154
3* Eczematoid dermatitis (HP:0000976)6.11232746
4* Recurrent gram-negative bacterial infections (HP:0005420)5.04817962
5Vacuolated lymphocytes (HP:0001922)4.64329174
6* Abnormality of macrophages (HP:0004311)4.54264220
7Myositis (HP:0100614)4.37878215
8* Recurrent skin infections (HP:0001581)4.17469423
9* Mediastinal lymphadenopathy (HP:0100721)4.12541237
10* Obstructive lung disease (HP:0006536)4.04227042
11* Chronic obstructive pulmonary disease (HP:0006510)4.04227042
12Systemic lupus erythematosus (HP:0002725)4.04172365
13* Recurrent fungal infections (HP:0002841)4.00260810
14Gastrointestinal infarctions (HP:0005244)4.00122939
15Increased cerebral lipofuscin (HP:0011813)3.97896734
16Increased neuronal autofluorescent lipopigment (HP:0002074)3.76184555
17Orchitis (HP:0100796)3.73084157
18Elevated erythrocyte sedimentation rate (HP:0003565)3.63398737
19* Gingivitis (HP:0000230)3.59788368
20Retrobulbar optic neuritis (HP:0100654)3.56674850
21Optic neuritis (HP:0100653)3.56674850
22Recurrent viral infections (HP:0004429)3.51477800
23Chronic mucocutaneous candidiasis (HP:0002728)3.45847444
24Recurrent cutaneous fungal infections (HP:0011370)3.45847444
25* Cellulitis (HP:0100658)3.44400932
26Stomatitis (HP:0010280)3.39642232
27T lymphocytopenia (HP:0005403)3.31603151
28* Meningitis (HP:0001287)3.26005960
29Abnormality of liposaccharide metabolism (HP:0010968)3.24595703
30Abnormality of glycosphingolipid metabolism (HP:0004343)3.24595703
31Abnormality of glycolipid metabolism (HP:0010969)3.24595703
32Dysostosis multiplex (HP:0000943)3.24246581
33Periodontitis (HP:0000704)3.20914094
34Vasculitis (HP:0002633)3.17406606
35Prostate neoplasm (HP:0100787)3.15406944
36Abnormality of T cell number (HP:0011839)3.14299795
37Autoimmune thrombocytopenia (HP:0001973)3.10525919
38Spontaneous hematomas (HP:0007420)3.08907659
39Amyloidosis (HP:0011034)3.03009865
40Disinhibition (HP:0000734)2.95200844
41IgM deficiency (HP:0002850)2.92194124
42Petechiae (HP:0000967)2.91318334
43Pustule (HP:0200039)2.87707217
44Episodic fever (HP:0001954)2.83649598
45Chronic otitis media (HP:0000389)2.79992042
46Glomerulonephritis (HP:0000099)2.78480213
47Abnormal delayed hypersensitivity skin test (HP:0002963)2.76175653
48Peritonitis (HP:0002586)2.73449778
49Inflammation of the large intestine (HP:0002037)2.73134334
50* Osteomyelitis (HP:0002754)2.72238460
51Agnosia (HP:0010524)2.72206108
52Prolonged bleeding time (HP:0003010)2.71919907
53Anorexia (HP:0002039)2.69622484
54Urinary glycosaminoglycan excretion (HP:0003541)2.66443917
55Mucopolysacchariduria (HP:0008155)2.66443917
56Pulmonary embolism (HP:0002204)2.66424102
57Abnormality of the prostate (HP:0008775)2.66190527
58Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.65762617
59Interstitial pulmonary disease (HP:0006530)2.65605544
60Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.63907595
61Axonal loss (HP:0003447)2.63297449
62Hypochromic microcytic anemia (HP:0004840)2.63177764
63Thrombocytosis (HP:0001894)2.61246621
64Abnormality of mucopolysaccharide metabolism (HP:0011020)2.61066310
65Abnormality of polysaccharide metabolism (HP:0011012)2.61066310
66Abnormality of glycosaminoglycan metabolism (HP:0004371)2.61066310
67Pulmonary infiltrates (HP:0002113)2.60701816
68* Recurrent pneumonia (HP:0006532)2.60330983
69Leukocytosis (HP:0001974)2.58482634
70Basal ganglia calcification (HP:0002135)2.57188596
71Gangrene (HP:0100758)2.55603106
72Gastrointestinal inflammation (HP:0004386)2.54287886
73Colitis (HP:0002583)2.51981869
74Hematochezia (HP:0002573)2.49469570
75Increased IgM level (HP:0003496)2.49402603
76Arterial thrombosis (HP:0004420)2.48800649
77* Urticaria (HP:0001025)2.46463376
78Hemoptysis (HP:0002105)2.43958570
79Epistaxis (HP:0000421)2.42371144
80Abnormality of T cells (HP:0002843)2.42290027
81Gingival bleeding (HP:0000225)2.41579754
82Hypochromic anemia (HP:0001931)2.40796293
83Albinism (HP:0001022)2.39200042
84Agammaglobulinemia (HP:0004432)2.35672215
85Abnormality of the pleura (HP:0002103)2.35345904
86Eosinophilia (HP:0001880)2.33272119
87* Recurrent lower respiratory tract infections (HP:0002783)2.30987336
88Hepatosplenomegaly (HP:0001433)2.29263001
89Keratoconjunctivitis sicca (HP:0001097)2.26660243
90Abnormality of the endocardium (HP:0004306)2.23308977
91Loss of speech (HP:0002371)2.23029412
92Purpura (HP:0000979)2.22110733
93Thoracic kyphosis (HP:0002942)2.21303268
94Glomerulopathy (HP:0100820)2.20333274
95Abnormality of the peritoneum (HP:0002585)2.18047332
96Increased serum ferritin (HP:0003281)2.17659739
97Polyneuropathy (HP:0001271)2.16868390
98Vertigo (HP:0002321)2.15886470
99Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.15883006
100Cheilitis (HP:0100825)2.15489626
101Granulocytopenia (HP:0001913)2.14024255
102J-shaped sella turcica (HP:0002680)2.11794388
103Thyroiditis (HP:0100646)2.10629225
104Abnormality of T cell physiology (HP:0011840)2.10605347
105Keratoconjunctivitis (HP:0001096)2.09752670
106Panhypogammaglobulinemia (HP:0003139)2.09743049
107Encephalitis (HP:0002383)2.09437147
108Chest pain (HP:0100749)2.07944017
109Increased IgE level (HP:0003212)2.07676463
110Slow saccadic eye movements (HP:0000514)2.07045529
111Impaired platelet aggregation (HP:0003540)2.05949584
112Abnormal platelet function (HP:0011869)2.05949584
113Lymphopenia (HP:0001888)2.05003252
114Premature loss of primary teeth (HP:0006323)2.03966924
115Joint hemorrhage (HP:0005261)2.03631655
116Abnormality of cells of the lymphoid lineage (HP:0012140)2.02143867
117Acne (HP:0001061)2.00899492
118Thick nail (HP:0001805)2.00543010
119Gastrointestinal stroma tumor (HP:0100723)1.99858250
120* Sepsis (HP:0100806)1.98394785
121Keratitis (HP:0000491)1.98252300
122* Skin ulcer (HP:0200042)1.97337178
123Abnormality of iron homeostasis (HP:0011031)1.96898834
124Microcytic anemia (HP:0001935)1.96732743
125Myocardial infarction (HP:0001658)1.96689170
126Abnormality of the pericardium (HP:0001697)1.94731794
127Amaurosis fugax (HP:0100576)1.94378756
128Viral hepatitis (HP:0006562)1.93644415
129Abnormality of the thoracic spine (HP:0100711)1.90667230
130Hypergammaglobulinemia (HP:0010702)1.90080191
131Subacute progressive viral hepatitis (HP:0006572)1.89155911
132Osteolytic defects of the hand bones (HP:0009699)1.87184861

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK44.38064221
2BLK3.85707519
3RIPK43.54604418
4MAP4K13.41423478
5MAP3K143.04853268
6IRAK32.82673247
7KIT2.81461443
8TYK22.50557266
9TBK12.43722176
10BTK2.35737568
11PRPF4B2.21490833
12CSF1R2.19361596
13TEC2.16480366
14TGFBR22.04854972
15IKBKB1.97893719
16TXK1.82425507
17IKBKE1.80649902
18FES1.80418063
19TAOK31.80211626
20SYK1.78028979
21ZAP701.76588888
22JAK31.72923125
23TAOK11.72607031
24HCK1.64716687
25ERN11.64179426
26CSK1.62516169
27MAP2K31.61251587
28CLK11.59791396
29EPHB11.53541499
30JAK11.44097045
31LYN1.43503633
32STK101.43369126
33PIM21.35349067
34MAP3K11.31182735
35KSR21.29162173
36PIM11.22604372
37IRAK21.20170185
38MAP3K131.18291955
39LCK1.17699612
40TAOK21.13287307
41MATK1.13159201
42FGR1.08654211
43ITK1.06313674
44RPS6KA41.05390935
45TRPM71.03989251
46CHUK1.01959174
47PBK1.01551637
48STK40.98316790
49NEK90.97536868
50GRK60.93614983
51YES10.93389027
52NME20.91550312
53GRK70.91414540
54MARK30.91040378
55JAK20.86054794
56PDK10.85787446
57CAMK1D0.85747640
58MAP3K20.85511873
59MARK20.84112861
60EIF2AK20.83585396
61PDPK10.77630531
62CDC42BPA0.74310650
63SIK20.71076304
64MAP3K110.67784198
65PAK40.67615973
66LRRK20.66341957
67FLT30.64727995
68PRKCD0.63213019
69FYN0.62933777
70ABL10.60591367
71RPS6KA60.60555616
72SIK30.59378976
73SGK30.58989451
74MAP3K120.58423870
75MOS0.57248221
76TRIB30.57226594
77MAPKAPK20.56051693
78MAP2K40.55876278
79MAP3K30.55673606
80FGFR30.55516971
81KSR10.55311983
82BMPR20.55152747
83IRAK10.54746324
84CDK190.54527335
85PRKD20.53954740
86MAPK120.52510031
87PTK2B0.52371414
88CDK60.52298297
89ABL20.51824670
90ZAK0.50880349
91EPHA30.49793311
92DAPK20.49349527
93RPS6KL10.49344323
94RPS6KC10.49344323
95EIF2AK30.49143284
96RAF10.48909275
97MAPK70.48762181
98FGFR40.46812496
99ADRBK20.46743950
100STK110.45767309
101DYRK1B0.45225972
102EGFR0.44921084
103MAPK40.44742842
104ACVR1B0.43484323
105MAP2K60.42460733
106SGK20.41555553
107TNK20.40652461
108HIPK20.40409204
109RIPK10.39484423
110SCYL20.39333631
111PIK3CG0.38824877
112MAP3K60.38739891
113CAMKK10.38431901
114BMX0.35992477
115VRK10.35962295
116MST40.35619047
117TESK20.35241731
118PTK60.34980936
119TTN0.34394456
120MAP3K50.34232937
121SMG10.33982439
122RET0.33873668
123CAMKK20.33699307
124CAMK1G0.33540745
125PKN20.31418840
126MAP3K70.31339394
127NLK0.30391755
128NEK20.29882250
129GRK10.29533441
130PRKCQ0.29484312
131DYRK30.29388975
132MAP3K100.29336778
133MAP3K80.29200109
134CDK90.28931521
135RPS6KA20.28579023
136STK240.28560787
137CDK40.28125780

Predicted pathways (KEGG)

RankGene SetZ-score
1* Leishmaniasis_Homo sapiens_hsa051403.30050017
2Staphylococcus aureus infection_Homo sapiens_hsa051502.89423954
3Other glycan degradation_Homo sapiens_hsa005112.53414950
4* Osteoclast differentiation_Homo sapiens_hsa043802.52829338
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.43992036
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.43370167
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.35917102
8B cell receptor signaling pathway_Homo sapiens_hsa046622.27569674
9Pertussis_Homo sapiens_hsa051332.25136083
10Tuberculosis_Homo sapiens_hsa051522.22825537
11Lysosome_Homo sapiens_hsa041422.17236569
12Legionellosis_Homo sapiens_hsa051342.12680400
13NOD-like receptor signaling pathway_Homo sapiens_hsa046212.00080822
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.99176305
15Measles_Homo sapiens_hsa051621.90695764
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.89923752
17Malaria_Homo sapiens_hsa051441.89021925
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.88914949
19Hematopoietic cell lineage_Homo sapiens_hsa046401.85648580
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.75560163
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.74188183
22Graft-versus-host disease_Homo sapiens_hsa053321.70385390
23Asthma_Homo sapiens_hsa053101.69860627
24Primary immunodeficiency_Homo sapiens_hsa053401.61127900
25Rheumatoid arthritis_Homo sapiens_hsa053231.60898152
26* Phagosome_Homo sapiens_hsa041451.60781835
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.57456356
28Influenza A_Homo sapiens_hsa051641.55113911
29Antigen processing and presentation_Homo sapiens_hsa046121.53604348
30Toxoplasmosis_Homo sapiens_hsa051451.52416570
31Salmonella infection_Homo sapiens_hsa051321.49975354
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.49707267
33Allograft rejection_Homo sapiens_hsa053301.48806446
34Herpes simplex infection_Homo sapiens_hsa051681.47666187
35Chemokine signaling pathway_Homo sapiens_hsa040621.44326044
36Shigellosis_Homo sapiens_hsa051311.44312389
37TNF signaling pathway_Homo sapiens_hsa046681.40792422
38Apoptosis_Homo sapiens_hsa042101.39340496
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.38013622
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.31164119
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.31065259
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.20097059
43* Leukocyte transendothelial migration_Homo sapiens_hsa046701.15965121
44Hepatitis B_Homo sapiens_hsa051611.14788973
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.02658256
46African trypanosomiasis_Homo sapiens_hsa051431.01836674
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99030761
48Acute myeloid leukemia_Homo sapiens_hsa052210.98872318
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.97735826
50Platelet activation_Homo sapiens_hsa046110.94615983
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93364922
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91597940
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83696374
54Hepatitis C_Homo sapiens_hsa051600.82879845
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82688995
56Chronic myeloid leukemia_Homo sapiens_hsa052200.82103192
57T cell receptor signaling pathway_Homo sapiens_hsa046600.81193590
58Pancreatic cancer_Homo sapiens_hsa052120.80716643
59Viral myocarditis_Homo sapiens_hsa054160.79045562
60Epstein-Barr virus infection_Homo sapiens_hsa051690.75759064
61Renal cell carcinoma_Homo sapiens_hsa052110.74102611
62DNA replication_Homo sapiens_hsa030300.73992787
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73707468
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72978847
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71053726
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.69332619
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.67068677
68Type I diabetes mellitus_Homo sapiens_hsa049400.67032575
69Caffeine metabolism_Homo sapiens_hsa002320.66561377
70Sphingolipid metabolism_Homo sapiens_hsa006000.66314985
71Amoebiasis_Homo sapiens_hsa051460.61657005
72Base excision repair_Homo sapiens_hsa034100.61479832
73Homologous recombination_Homo sapiens_hsa034400.59036683
74Autoimmune thyroid disease_Homo sapiens_hsa053200.58454065
75Viral carcinogenesis_Homo sapiens_hsa052030.58352837
76Dorso-ventral axis formation_Homo sapiens_hsa043200.55834286
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.55068568
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.54801289
79Complement and coagulation cascades_Homo sapiens_hsa046100.54177935
80GnRH signaling pathway_Homo sapiens_hsa049120.52716324
81Type II diabetes mellitus_Homo sapiens_hsa049300.49588142
82Prolactin signaling pathway_Homo sapiens_hsa049170.49276384
83Non-homologous end-joining_Homo sapiens_hsa034500.48917522
84Endometrial cancer_Homo sapiens_hsa052130.47198660
85Systemic lupus erythematosus_Homo sapiens_hsa053220.46464710
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44794336
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43416865
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42785667
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42311216
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41930716
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41633757
92Small cell lung cancer_Homo sapiens_hsa052220.41567530
93mTOR signaling pathway_Homo sapiens_hsa041500.41408893
94Renin-angiotensin system_Homo sapiens_hsa046140.41287680
95Insulin resistance_Homo sapiens_hsa049310.40970841
96HIF-1 signaling pathway_Homo sapiens_hsa040660.40578535
97Endocytosis_Homo sapiens_hsa041440.39710988
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39283307
99p53 signaling pathway_Homo sapiens_hsa041150.38490478
100Choline metabolism in cancer_Homo sapiens_hsa052310.37831884
101Non-small cell lung cancer_Homo sapiens_hsa052230.37698408
102HTLV-I infection_Homo sapiens_hsa051660.37259457
103MAPK signaling pathway_Homo sapiens_hsa040100.36859574
104Bladder cancer_Homo sapiens_hsa052190.36260853
105Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35834093
106Arachidonic acid metabolism_Homo sapiens_hsa005900.33343124
107Inositol phosphate metabolism_Homo sapiens_hsa005620.33051278
108Pentose phosphate pathway_Homo sapiens_hsa000300.32496915
109Fanconi anemia pathway_Homo sapiens_hsa034600.31914110
110Rap1 signaling pathway_Homo sapiens_hsa040150.31235094
111VEGF signaling pathway_Homo sapiens_hsa043700.30282259
112ErbB signaling pathway_Homo sapiens_hsa040120.30166412
113Notch signaling pathway_Homo sapiens_hsa043300.29497154
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26876988
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26784981
116Mismatch repair_Homo sapiens_hsa034300.23563174
117Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23480255
118FoxO signaling pathway_Homo sapiens_hsa040680.23251859
119Collecting duct acid secretion_Homo sapiens_hsa049660.22948508
120ABC transporters_Homo sapiens_hsa020100.21274198

Most similar genes based on co-expression Upload to Enrichr

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