NCF1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)6.29172199
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.29172199
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.10537909
4positive regulation by symbiont of host defense response (GO:0052509)5.89168215
5modulation by symbiont of host defense response (GO:0052031)5.89168215
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.89168215
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.89168215
8positive regulation by organism of defense response of other organism involved in symbiotic interact5.89168215
9modulation by symbiont of host immune response (GO:0052553)5.89168215
10positive regulation of gamma-delta T cell activation (GO:0046645)5.72354413
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.53131848
12antigen processing and presentation of endogenous antigen (GO:0019883)5.51730416
13neutrophil activation involved in immune response (GO:0002283)5.29652535
14detection of other organism (GO:0098543)5.22618753
15detection of bacterium (GO:0016045)5.06997408
16macrophage activation involved in immune response (GO:0002281)5.01130635
17regulation of B cell receptor signaling pathway (GO:0050855)5.00826675
18antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.00667155
19response to peptidoglycan (GO:0032494)4.80103258
20leukocyte aggregation (GO:0070486)4.55647786
21negative regulation of interleukin-12 production (GO:0032695)4.50161266
22detection of external biotic stimulus (GO:0098581)4.46531591
23regulation of interferon-beta biosynthetic process (GO:0045357)4.39157105
24immunoglobulin mediated immune response (GO:0016064)4.37718746
25respiratory burst (GO:0045730)4.28495247
26positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.27392795
27detection of molecule of bacterial origin (GO:0032490)4.25166715
28neutrophil activation (GO:0042119)4.19179977
29cellular extravasation (GO:0045123)4.18325983
30positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.17494720
31negative regulation of lymphocyte mediated immunity (GO:0002707)4.16571423
32regulation of gamma-delta T cell activation (GO:0046643)4.10485483
33leukocyte migration involved in inflammatory response (GO:0002523)4.09107077
34response to host immune response (GO:0052572)4.08366646
35response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.08366646
36detection of biotic stimulus (GO:0009595)3.90251176
37granulocyte activation (GO:0036230)3.87952974
38microglial cell activation (GO:0001774)3.86094581
39cellular response to type I interferon (GO:0071357)3.85965191
40type I interferon signaling pathway (GO:0060337)3.85965191
41response to interleukin-15 (GO:0070672)3.85869472
42response to type I interferon (GO:0034340)3.82927446
43B cell receptor signaling pathway (GO:0050853)3.74939916
44neutrophil mediated immunity (GO:0002446)3.73789030
45response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.73738585
46response to host (GO:0075136)3.73738585
47response to host defenses (GO:0052200)3.73738585
48negative regulation of leukocyte mediated immunity (GO:0002704)3.70132943
49myeloid cell activation involved in immune response (GO:0002275)3.68680756
50regulation of mast cell degranulation (GO:0043304)3.66639825
51macrophage activation (GO:0042116)3.61598617
52production of molecular mediator involved in inflammatory response (GO:0002532)3.60393670
53cellular response to interleukin-15 (GO:0071350)3.54697356
54negative regulation of T cell mediated immunity (GO:0002710)3.52769330
55negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.50615731
56defense response to protozoan (GO:0042832)3.50207577
57B cell mediated immunity (GO:0019724)3.48376666
58interferon-gamma-mediated signaling pathway (GO:0060333)3.47280326
59regulation of gamma-delta T cell differentiation (GO:0045586)3.46265991
60germinal center formation (GO:0002467)3.43782156
61regulation of mast cell activation involved in immune response (GO:0033006)3.37242019
62regulation of myeloid leukocyte mediated immunity (GO:0002886)3.36529336
63response to muramyl dipeptide (GO:0032495)3.33688256
64antigen processing and presentation via MHC class Ib (GO:0002475)3.32390486
65regulation of dendritic cell antigen processing and presentation (GO:0002604)3.31824208
66regulation of T cell tolerance induction (GO:0002664)3.30933691
67positive regulation of mast cell activation (GO:0033005)3.30908058
68regulation of B cell differentiation (GO:0045577)3.24888783
69regulation of leukocyte degranulation (GO:0043300)3.21804524
70regulation of mast cell activation (GO:0033003)3.21128202
71myeloid leukocyte mediated immunity (GO:0002444)3.21079957
72positive regulation of interferon-alpha production (GO:0032727)3.18338413
73lipopolysaccharide-mediated signaling pathway (GO:0031663)3.17953776
74negative regulation of phagocytosis (GO:0050765)3.17509209
75positive regulation of B cell differentiation (GO:0045579)3.17493573
76regulation of tolerance induction (GO:0002643)3.17091999
77regulation of T-helper 2 cell differentiation (GO:0045628)3.16377772
78regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.12282121
79response to protozoan (GO:0001562)3.12066793
80positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.11032278
81leukocyte degranulation (GO:0043299)3.09343562
82regulation of interferon-alpha production (GO:0032647)3.05348749
83regulation of T cell mediated cytotoxicity (GO:0001914)3.04771962
84positive thymic T cell selection (GO:0045059)3.04437912
85regulation of antigen processing and presentation (GO:0002577)3.01922756
86negative regulation of innate immune response (GO:0045824)2.97138142
87T cell migration (GO:0072678)2.97044731
88negative regulation of cytokine production involved in immune response (GO:0002719)2.96969175
89negative regulation of T-helper cell differentiation (GO:0045623)2.96698439
90negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.96698439
91negative thymic T cell selection (GO:0045060)2.96652757
92positive regulation of T cell mediated cytotoxicity (GO:0001916)2.95121503
93negative regulation of alpha-beta T cell activation (GO:0046636)2.93539145
94negative regulation of interleukin-6 production (GO:0032715)2.93428035
95regulation of natural killer cell mediated immunity (GO:0002715)2.91581594
96regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.91581594
97regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.90414846
98negative regulation of erythrocyte differentiation (GO:0045647)2.89034444
99regulation of alpha-beta T cell proliferation (GO:0046640)2.88933910
100regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.88390590

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.89273521
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.54092201
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.51615228
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.71603874
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.71304465
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.27861800
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.25866774
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.25596753
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.11277791
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.09342007
11VDR_21846776_ChIP-Seq_THP-1_Human2.87771877
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.84244378
13SPI1_23547873_ChIP-Seq_NB4_Human2.79681680
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.71283780
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.71112959
16VDR_24763502_ChIP-Seq_THP-1_Human2.68657854
17RUNX_20019798_ChIP-Seq_JUKART_Human2.59463808
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.55935773
19* SPI1_23127762_ChIP-Seq_K562_Human2.54222044
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.51022800
21MAF_26560356_Chip-Seq_TH1_Human2.45644086
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.40965952
23MYC_22102868_ChIP-Seq_BL_Human2.40582191
24E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.40548782
25MYB_26560356_Chip-Seq_TH2_Human2.34957114
26STAT4_19710469_ChIP-ChIP_TH1__Mouse2.31944554
27RUNX1_22412390_ChIP-Seq_EML_Mouse2.24742805
28SCL_19346495_ChIP-Seq_HPC-7_Human2.16783291
29UTX_26944678_Chip-Seq_JUKART_Human2.16699280
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.13146810
31BRD4_27068464_Chip-Seq_AML-cells_Mouse2.12754569
32FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.09760964
33MYB_26560356_Chip-Seq_TH1_Human2.04044867
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.98754251
35RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.96785613
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.95762739
37TCF7_22412390_ChIP-Seq_EML_Mouse1.91640101
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.88785763
39MAF_26560356_Chip-Seq_TH2_Human1.82124330
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.80927659
41VDR_24787735_ChIP-Seq_THP-1_Human1.71104930
42KDM2B_26808549_Chip-Seq_DND41_Human1.69186958
43GATA3_27048872_Chip-Seq_THYMUS_Human1.64925396
44NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.63886910
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.63144664
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.63003606
47KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.59308052
48CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.57203766
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.55691665
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54106789
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.53960741
52LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.52065016
53GATA1_19941827_ChIP-Seq_MEL_Mouse1.51549449
54KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.49029352
55TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.48592538
56CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.41113268
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.37919916
58ELK3_25401928_ChIP-Seq_HUVEC_Human1.35276445
59PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34501751
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.33803626
61LXR_22292898_ChIP-Seq_THP-1_Human1.32871059
62GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.30997991
63STAT6_21828071_ChIP-Seq_BEAS2B_Human1.30182104
64SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.29632039
65PU_27001747_Chip-Seq_BMDM_Mouse1.29558306
66PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28465469
67PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27445522
68* GATA3_26560356_Chip-Seq_TH2_Human1.27162841
69IKZF1_21737484_ChIP-ChIP_HCT116_Human1.26633079
70SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26228268
71CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24559487
72GATA1_22383799_ChIP-Seq_G1ME_Mouse1.23778486
73GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20780347
74CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18333876
75PU.1_20513432_ChIP-Seq_Bcells_Mouse1.16125919
76VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.15587187
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15498535
78* BCL6_27268052_Chip-Seq_Bcells_Human1.14968284
79GATA1_22025678_ChIP-Seq_K562_Human1.14599537
80GATA1_19941826_ChIP-Seq_K562_Human1.14434179
81SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12656002
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10752340
83KDM2B_26808549_Chip-Seq_JURKAT_Human1.10324103
84GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06874280
85NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06801416
86* BCOR_27268052_Chip-Seq_Bcells_Human1.06108921
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05276555
88PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04336969
89ELF1_17652178_ChIP-ChIP_JURKAT_Human1.03974474
90STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03693017
91GATA2_21666600_ChIP-Seq_HMVEC_Human0.94393054
92CTCF_27219007_Chip-Seq_ERYTHROID_Human0.89651341
93NCOR1_26117541_ChIP-Seq_K562_Human0.88902417
94RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88420851
95GATA2_19941826_ChIP-Seq_K562_Human0.86469597
96SPI1_20517297_ChIP-Seq_HL60_Human0.84178053
97RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.83662227
98TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.82950481
99STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.81453995
100ELF1_20517297_ChIP-Seq_JURKAT_Human0.79960898

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.73698969
2MP0003436_decreased_susceptibility_to4.31544505
3MP0003303_peritoneal_inflammation4.06643956
4MP0001835_abnormal_antigen_presentation3.90541192
5MP0002419_abnormal_innate_immunity3.22493694
6MP0005671_abnormal_response_to3.17761944
7MP0005387_immune_system_phenotype3.13936809
8MP0001790_abnormal_immune_system3.13936809
9MP0009785_altered_susceptibility_to3.11475821
10MP0001800_abnormal_humoral_immune3.09194348
11MP0000685_abnormal_immune_system3.02868754
12MP0005025_abnormal_response_to3.01020066
13MP0005000_abnormal_immune_tolerance3.00925349
14MP0002723_abnormal_immune_serum2.73188274
15MP0002452_abnormal_antigen_presenting2.67056287
16MP0006082_CNS_inflammation2.66961582
17MP0002420_abnormal_adaptive_immunity2.63637617
18MP0001819_abnormal_immune_cell2.60969297
19MP0002148_abnormal_hypersensitivity_rea2.49911402
20MP0003300_gastrointestinal_ulcer2.40559688
21MP0003191_abnormal_cellular_cholesterol2.23556822
22MP0001533_abnormal_skeleton_physiology2.18478411
23MP0003763_abnormal_thymus_physiology2.11686991
24MP0002405_respiratory_system_inflammati2.03919136
25MP0002398_abnormal_bone_marrow1.97432000
26MP0000716_abnormal_immune_system1.95860983
27MP0008260_abnormal_autophagy1.93218946
28MP0005464_abnormal_platelet_physiology1.91509402
29MP0001845_abnormal_inflammatory_respons1.85551463
30MP0010155_abnormal_intestine_physiology1.85275465
31MP0003172_abnormal_lysosome_physiology1.82929100
32MP0003183_abnormal_peptide_metabolism1.74892261
33MP0009278_abnormal_bone_marrow1.74124003
34MP0004947_skin_inflammation1.70796998
35MP0002132_abnormal_respiratory_system1.66442207
36MP0000689_abnormal_spleen_morphology1.64007791
37MP0009764_decreased_sensitivity_to1.59556115
38MP0002722_abnormal_immune_system1.58655446
39MP0005451_abnormal_body_composition1.57633797
40MP0009333_abnormal_splenocyte_physiolog1.56447541
41MP0004510_myositis1.55325989
42MP0000465_gastrointestinal_hemorrhage1.55209392
43MP0002429_abnormal_blood_cell1.54307804
44MP0008469_abnormal_protein_level1.53816267
45MP0005310_abnormal_salivary_gland1.52572582
46MP0003828_pulmonary_edema1.49936215
47MP0002396_abnormal_hematopoietic_system1.47703301
48MP0003866_abnormal_defecation1.46932664
49MP0002277_abnormal_respiratory_mucosa1.34326096
50MP0000703_abnormal_thymus_morphology1.33812041
51MP0003075_altered_response_to1.32361618
52MP0000858_altered_metastatic_potential1.32101053
53MP0004883_abnormal_blood_vessel1.31803012
54MP0004381_abnormal_hair_follicle1.26262926
55MP0005397_hematopoietic_system_phenotyp1.24327764
56MP0001545_abnormal_hematopoietic_system1.24327764
57MP0005058_abnormal_lysosome_morphology1.20097162
58MP0002998_abnormal_bone_remodeling1.19735620
59MP0001851_eye_inflammation1.15804004
60MP0003690_abnormal_glial_cell1.05223780
61MP0000343_altered_response_to1.03277768
62MP0005164_abnormal_response_to1.02914036
63MP0005166_decreased_susceptibility_to1.02339700
64MP0002138_abnormal_hepatobiliary_system1.01631237
65MP0001853_heart_inflammation0.97911636
66MP0002166_altered_tumor_susceptibility0.96862566
67MP0008004_abnormal_stomach_pH0.94374610
68MP0003806_abnormal_nucleotide_metabolis0.93467770
69MP0001873_stomach_inflammation0.90113079
70MP0003448_altered_tumor_morphology0.88866714
71MP0009763_increased_sensitivity_to0.86803689
72MP0005390_skeleton_phenotype0.86612465
73MP0001663_abnormal_digestive_system0.86136475
74MP0000604_amyloidosis0.84480132
75MP0000490_abnormal_crypts_of0.79743843
76MP0005075_abnormal_melanosome_morpholog0.76862044
77MP0003656_abnormal_erythrocyte_physiolo0.76046687
78MP0003045_fibrosis0.75739168
79MP0004808_abnormal_hematopoietic_stem0.74618514
80MP0002933_joint_inflammation0.70711794
81MP0008874_decreased_physiological_sensi0.69005691
82MP0009765_abnormal_xenobiotic_induced0.67887945
83MP0002332_abnormal_exercise_endurance0.67200587
84MP0009840_abnormal_foam_cell0.64470538
85MP0003795_abnormal_bone_structure0.63447663
86MP0001986_abnormal_taste_sensitivity0.63131804
87MP0000249_abnormal_blood_vessel0.62282386
88MP0003221_abnormal_cardiomyocyte_apopto0.59964955
89MP0002006_tumorigenesis0.59627917
90MP0000015_abnormal_ear_pigmentation0.56697321
91MP0005319_abnormal_enzyme/_coenzyme0.56269771
92MP0002928_abnormal_bile_duct0.53234553
93MP0003091_abnormal_cell_migration0.52371739
94MP0002693_abnormal_pancreas_physiology0.48236743
95MP0002019_abnormal_tumor_incidence0.47472299
96MP0000609_abnormal_liver_physiology0.46079635
97MP0005381_digestive/alimentary_phenotyp0.45918086
98MP0003453_abnormal_keratinocyte_physiol0.45547167
99MP0005167_abnormal_blood-brain_barrier0.44418751
100MP0005083_abnormal_biliary_tract0.43866434

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)7.10942246
2Recurrent bacterial skin infections (HP:0005406)6.31251116
3Recurrent abscess formation (HP:0002722)6.31245069
4Myositis (HP:0100614)5.77680560
5Abnormality of macrophages (HP:0004311)5.72266267
6Orchitis (HP:0100796)5.52725776
7Recurrent gram-negative bacterial infections (HP:0005420)5.36526579
8Retrobulbar optic neuritis (HP:0100654)5.26176313
9Optic neuritis (HP:0100653)5.26176313
10Stomatitis (HP:0010280)4.85619681
11Mediastinal lymphadenopathy (HP:0100721)4.64034001
12Elevated erythrocyte sedimentation rate (HP:0003565)4.44480672
13Chronic obstructive pulmonary disease (HP:0006510)4.42202701
14Obstructive lung disease (HP:0006536)4.42202701
15Meningitis (HP:0001287)4.37610966
16Recurrent fungal infections (HP:0002841)4.26846781
17Gastrointestinal infarctions (HP:0005244)4.22056153
18Recurrent skin infections (HP:0001581)4.04421613
19Abnormal delayed hypersensitivity skin test (HP:0002963)4.00619402
20Hypochromic microcytic anemia (HP:0004840)3.84186061
21Keratoconjunctivitis sicca (HP:0001097)3.79966819
22Encephalitis (HP:0002383)3.76990287
23Vasculitis (HP:0002633)3.74759583
24Urticaria (HP:0001025)3.70202824
25Cellulitis (HP:0100658)3.66579370
26Increased IgE level (HP:0003212)3.62727432
27Gingivitis (HP:0000230)3.62690824
28Spontaneous hematomas (HP:0007420)3.59388935
29Keratoconjunctivitis (HP:0001096)3.51415613
30Chronic mucocutaneous candidiasis (HP:0002728)3.50941948
31Recurrent cutaneous fungal infections (HP:0011370)3.50941948
32Hypochromic anemia (HP:0001931)3.35223820
33Chest pain (HP:0100749)3.15208471
34Pulmonary infiltrates (HP:0002113)3.13098415
35Prolonged bleeding time (HP:0003010)3.09535931
36Hemoptysis (HP:0002105)3.07213404
37Episodic fever (HP:0001954)2.95370722
38Recurrent viral infections (HP:0004429)2.90879008
39Inflammation of the large intestine (HP:0002037)2.90728020
40T lymphocytopenia (HP:0005403)2.90533617
41Osteomyelitis (HP:0002754)2.86365121
42Abnormality of T cell number (HP:0011839)2.83067192
43Gastrointestinal inflammation (HP:0004386)2.80145326
44Increased IgM level (HP:0003496)2.78806566
45Anorexia (HP:0002039)2.76832911
46Gingival bleeding (HP:0000225)2.75146684
47Arterial thrombosis (HP:0004420)2.74623908
48Leukocytosis (HP:0001974)2.73905256
49Lymphopenia (HP:0001888)2.66653409
50Petechiae (HP:0000967)2.65668526
51Pulmonary embolism (HP:0002204)2.65555103
52Peritonitis (HP:0002586)2.63624837
53Agammaglobulinemia (HP:0004432)2.62553510
54Sepsis (HP:0100806)2.61991406
55Panhypogammaglobulinemia (HP:0003139)2.61680872
56Epistaxis (HP:0000421)2.58426054
57Abnormality of T cells (HP:0002843)2.57305913
58Pustule (HP:0200039)2.57124845
59Gastrointestinal stroma tumor (HP:0100723)2.50635992
60Amyloidosis (HP:0011034)2.50436646
61Abnormality of cells of the lymphoid lineage (HP:0012140)2.49619373
62Abnormality of the pleura (HP:0002103)2.44162387
63Granulocytopenia (HP:0001913)2.43449572
64Colitis (HP:0002583)2.43392784
65Microcytic anemia (HP:0001935)2.42029022
66Gangrene (HP:0100758)2.41064939
67Recurrent pneumonia (HP:0006532)2.38970722
68Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.36905462
69Recurrent bronchitis (HP:0002837)2.33477709
70Hypergammaglobulinemia (HP:0010702)2.31015759
71Abnormality of T cell physiology (HP:0011840)2.26316045
72Abnormality of the peritoneum (HP:0002585)2.24989585
73Recurrent sinusitis (HP:0011108)2.20072185
74Purpura (HP:0000979)2.19826941
75IgM deficiency (HP:0002850)2.19748144
76Skin ulcer (HP:0200042)2.15778041
77Abnormality of glycolipid metabolism (HP:0010969)2.12851220
78Abnormality of liposaccharide metabolism (HP:0010968)2.12851220
79Abnormality of glycosphingolipid metabolism (HP:0004343)2.12851220
80Glomerulopathy (HP:0100820)2.12055332
81Hepatosplenomegaly (HP:0001433)2.12022626
82Recurrent lower respiratory tract infections (HP:0002783)2.11576198
83Abnormality of the endocardium (HP:0004306)2.11525257
84Premature loss of primary teeth (HP:0006323)2.10364856
85Chronic otitis media (HP:0000389)2.10045008
86Loss of speech (HP:0002371)2.09497035
87Increased cerebral lipofuscin (HP:0011813)2.09383302
88Abnormality of the pericardium (HP:0001697)2.05845360
89Eosinophilia (HP:0001880)2.04189203
90Increased serum ferritin (HP:0003281)2.03160880
91Restrictive lung disease (HP:0002091)2.02358400
92Slow saccadic eye movements (HP:0000514)1.98846936
93Acne (HP:0001061)1.96563599
94Keratitis (HP:0000491)1.95936688
95Skin rash (HP:0000988)1.95771988
96Vertigo (HP:0002321)1.92705022
97Polyneuropathy (HP:0001271)1.92177261
98Viral hepatitis (HP:0006562)1.91922093
99Abnormality of iron homeostasis (HP:0011031)1.91852792
100Verrucae (HP:0200043)1.91065235

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.94987111
2IRAK43.79252557
3MAP4K13.78850824
4BLK3.43994670
5ERN12.95106969
6TYK22.84095915
7MAP2K32.79025071
8CSK2.70594803
9FES2.39363683
10TNK22.35214919
11GRK62.23124191
12PRPF4B2.12513739
13ZAP701.90186875
14TAOK11.89822970
15FGR1.88956991
16BTK1.86445561
17EPHB11.84988995
18JAK31.84878570
19TXK1.82929062
20MAP3K141.81316462
21SYK1.80265672
22MAP3K111.78219679
23IKBKE1.75900218
24HCK1.73432892
25MAP3K31.72419929
26TBK11.62192594
27SIK31.50782646
28LYN1.49350795
29MAP3K131.40011960
30JAK21.36222383
31JAK11.31067326
32CSF1R1.27336695
33MAP3K11.20546828
34KSR21.19382343
35KIT1.18455059
36TESK21.18089200
37LCK1.16885884
38SIK21.13497799
39MARK31.11226976
40MATK1.10596479
41YES11.08458603
42TAOK21.06486879
43TAOK31.06274200
44IKBKB1.02210893
45MARK20.95855307
46ITK0.95142404
47BMPR20.95072571
48IRAK10.94972271
49IRAK20.91993569
50PRKD20.89211500
51CDK190.89052778
52STK100.88071182
53PDK10.83099277
54TEC0.82572296
55TRIB30.81012940
56PTK60.80142908
57SMG10.75272459
58PDPK10.70817713
59TGFBR20.69226953
60CDC42BPA0.69022777
61FYN0.68342236
62MAP3K60.63200213
63LRRK20.62584277
64IRAK30.61280538
65MAPK120.57585000
66SIK10.57145090
67MAP3K50.56531628
68MAP3K70.56496500
69PRKCQ0.56486180
70GRK70.56248207
71FGFR40.56133698
72PTK2B0.54096727
73DYRK1B0.52904489
74STK110.51451991
75PIM10.51156651
76MAPK70.49045822
77HIPK20.48154135
78MAP2K40.48097300
79FGFR30.47792630
80MAP3K20.44862842
81RAF10.44378548
82RPS6KC10.43039474
83RPS6KL10.43039474
84EPHA30.42384970
85MAP2K60.40302654
86MAPKAPK20.39218957
87SGK30.38021608
88RPS6KA60.35946194
89DAPK20.35928423
90KSR10.35464185
91PIK3CG0.35185768
92PRKCZ0.32124056
93NLK0.31744507
94STK380.31688311
95RET0.30807722
96PRKG20.30778108
97CAMKK10.30462178
98PRKCD0.29926942
99MAP3K80.27986141
100MOS0.26934205

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.16415052
2Osteoclast differentiation_Homo sapiens_hsa043803.03365146
3Staphylococcus aureus infection_Homo sapiens_hsa051502.92768061
4Allograft rejection_Homo sapiens_hsa053302.76264522
5Graft-versus-host disease_Homo sapiens_hsa053322.71052577
6Autoimmune thyroid disease_Homo sapiens_hsa053202.53350602
7B cell receptor signaling pathway_Homo sapiens_hsa046622.44689465
8Primary immunodeficiency_Homo sapiens_hsa053402.33434332
9Tuberculosis_Homo sapiens_hsa051522.22807109
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.20761186
11Toll-like receptor signaling pathway_Homo sapiens_hsa046202.17384926
12Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.05825804
13Type I diabetes mellitus_Homo sapiens_hsa049402.04613041
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.03471063
15Malaria_Homo sapiens_hsa051441.96969983
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.87420072
17Antigen processing and presentation_Homo sapiens_hsa046121.82960492
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.80153734
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.78371717
20Measles_Homo sapiens_hsa051621.77292856
21Asthma_Homo sapiens_hsa053101.73275924
22Hematopoietic cell lineage_Homo sapiens_hsa046401.71765648
23Viral myocarditis_Homo sapiens_hsa054161.70805425
24Chemokine signaling pathway_Homo sapiens_hsa040621.67412607
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.60432388
26Influenza A_Homo sapiens_hsa051641.60383773
27Toxoplasmosis_Homo sapiens_hsa051451.60341158
28Acute myeloid leukemia_Homo sapiens_hsa052211.57694106
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.55349473
30T cell receptor signaling pathway_Homo sapiens_hsa046601.53186426
31Herpes simplex infection_Homo sapiens_hsa051681.51873711
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.51151219
33Legionellosis_Homo sapiens_hsa051341.48627239
34Phagosome_Homo sapiens_hsa041451.45174377
35African trypanosomiasis_Homo sapiens_hsa051431.44956945
36TNF signaling pathway_Homo sapiens_hsa046681.36367375
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.31999088
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.31040147
39Other glycan degradation_Homo sapiens_hsa005111.25188154
40Rheumatoid arthritis_Homo sapiens_hsa053231.24255683
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.15024214
42Hepatitis B_Homo sapiens_hsa051611.12738120
43Hepatitis C_Homo sapiens_hsa051601.11062676
44Pertussis_Homo sapiens_hsa051331.08455187
45Salmonella infection_Homo sapiens_hsa051321.03528026
46Non-small cell lung cancer_Homo sapiens_hsa052231.00773578
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.00421941
48Shigellosis_Homo sapiens_hsa051311.00316681
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99210785
50Platelet activation_Homo sapiens_hsa046110.97804654
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94778782
52Apoptosis_Homo sapiens_hsa042100.91787545
53Pancreatic cancer_Homo sapiens_hsa052120.85765373
54VEGF signaling pathway_Homo sapiens_hsa043700.83629177
55Lysosome_Homo sapiens_hsa041420.82570308
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82407836
57Chronic myeloid leukemia_Homo sapiens_hsa052200.79583474
58Epstein-Barr virus infection_Homo sapiens_hsa051690.78937791
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77350761
60Prolactin signaling pathway_Homo sapiens_hsa049170.72994652
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.71091459
62Endocytosis_Homo sapiens_hsa041440.70952590
63Renal cell carcinoma_Homo sapiens_hsa052110.68071900
64Sphingolipid signaling pathway_Homo sapiens_hsa040710.66460240
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66386011
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.65818703
67Viral carcinogenesis_Homo sapiens_hsa052030.64735423
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60691971
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60144261
70Notch signaling pathway_Homo sapiens_hsa043300.58057361
71HTLV-I infection_Homo sapiens_hsa051660.57684396
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.57242412
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57218882
74FoxO signaling pathway_Homo sapiens_hsa040680.55839271
75Amoebiasis_Homo sapiens_hsa051460.53924939
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48596648
77GnRH signaling pathway_Homo sapiens_hsa049120.48465356
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47895012
79Endometrial cancer_Homo sapiens_hsa052130.46302345
80Choline metabolism in cancer_Homo sapiens_hsa052310.45629606
81HIF-1 signaling pathway_Homo sapiens_hsa040660.45549609
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44930871
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.44674284
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43042567
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42496934
86Type II diabetes mellitus_Homo sapiens_hsa049300.42355094
87MAPK signaling pathway_Homo sapiens_hsa040100.41919423
88Dorso-ventral axis formation_Homo sapiens_hsa043200.40171090
89Insulin resistance_Homo sapiens_hsa049310.39951609
90Regulation of autophagy_Homo sapiens_hsa041400.38058616
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37967088
92Colorectal cancer_Homo sapiens_hsa052100.37930088
93mTOR signaling pathway_Homo sapiens_hsa041500.37239209
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35098453
95Rap1 signaling pathway_Homo sapiens_hsa040150.34853191
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.34581393
97Inositol phosphate metabolism_Homo sapiens_hsa005620.32745230
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32512188
99ErbB signaling pathway_Homo sapiens_hsa040120.27151794
100Systemic lupus erythematosus_Homo sapiens_hsa053220.25315692

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