NCBP2-AS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine deoxyribonucleotide catabolic process (GO:0009223)6.04126717
2ribosomal small subunit assembly (GO:0000028)5.88358457
3regulation of mitochondrial translation (GO:0070129)5.62651143
4deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.22078435
5pyrimidine nucleotide catabolic process (GO:0006244)4.99495301
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.99413999
7energy coupled proton transport, down electrochemical gradient (GO:0015985)4.83698089
8ATP synthesis coupled proton transport (GO:0015986)4.83698089
9maturation of SSU-rRNA (GO:0030490)4.83111874
10deoxyribonucleotide catabolic process (GO:0009264)4.82004512
11protein complex biogenesis (GO:0070271)4.78795862
12pseudouridine synthesis (GO:0001522)4.64001808
13ribosomal small subunit biogenesis (GO:0042274)4.62173538
14pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.55563053
15base-excision repair, AP site formation (GO:0006285)4.55138037
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.53390211
17deoxyribose phosphate catabolic process (GO:0046386)4.52688446
18viral transcription (GO:0019083)4.50926583
19mitochondrial respiratory chain complex assembly (GO:0033108)4.38324992
20translational termination (GO:0006415)4.37902606
21metallo-sulfur cluster assembly (GO:0031163)4.23221498
22iron-sulfur cluster assembly (GO:0016226)4.23221498
23respiratory electron transport chain (GO:0022904)4.22545765
24DNA deamination (GO:0045006)4.15625187
25mitochondrial respiratory chain complex I assembly (GO:0032981)4.15097955
26NADH dehydrogenase complex assembly (GO:0010257)4.15097955
27mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.15097955
28electron transport chain (GO:0022900)4.13069324
29cytochrome complex assembly (GO:0017004)4.12882402
30translational elongation (GO:0006414)4.05292691
31SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.01656376
32purine deoxyribonucleotide catabolic process (GO:0009155)3.99939628
33chaperone-mediated protein transport (GO:0072321)3.97410847
34cotranslational protein targeting to membrane (GO:0006613)3.92719738
35protein targeting to ER (GO:0045047)3.89919026
36respiratory chain complex IV assembly (GO:0008535)3.84610757
37proteasome assembly (GO:0043248)3.83261488
38negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.81784371
39protein localization to endoplasmic reticulum (GO:0070972)3.80418968
40peptidyl-histidine modification (GO:0018202)3.75704947
412-deoxyribonucleotide metabolic process (GO:0009394)3.73665622
42establishment of protein localization to endoplasmic reticulum (GO:0072599)3.68991891
43deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.66899606
44cellular component biogenesis (GO:0044085)3.60265328
45negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.59727960
46oxidative phosphorylation (GO:0006119)3.59568803
47deoxyribose phosphate metabolic process (GO:0019692)3.54997198
48protein targeting to mitochondrion (GO:0006626)3.54309410
49ribosomal large subunit biogenesis (GO:0042273)3.52730398
50viral life cycle (GO:0019058)3.52711990
51translation (GO:0006412)3.51851438
52RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.48722547
53tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.48722547
54nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.45579739
55translational initiation (GO:0006413)3.45511617
56nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.45386388
57regulation of cellular amino acid metabolic process (GO:0006521)3.42993970
58lipopolysaccharide biosynthetic process (GO:0009103)3.40143169
59exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.39196389
60mannosylation (GO:0097502)3.38505693
61rRNA modification (GO:0000154)3.36467418
62establishment of protein localization to mitochondrial membrane (GO:0090151)3.36105912
63establishment of protein localization to mitochondrion (GO:0072655)3.34913366
64cellular protein complex disassembly (GO:0043624)3.34685508
65DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.34217518
66ribonucleoprotein complex biogenesis (GO:0022613)3.31616986
67positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.28073783
68negative regulation of DNA-templated transcription, elongation (GO:0032785)3.26314604
69signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.22971249
70signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.22971249
71signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.22971249
72intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.22429931
73signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.22429931
74negative regulation of ligase activity (GO:0051352)3.21370345
75negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.21370345
76deoxyribonucleotide metabolic process (GO:0009262)3.16448348
77negative regulation of telomere maintenance (GO:0032205)3.16342225
78regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.14417544
79protein localization to mitochondrion (GO:0070585)3.13369981
80ubiquinone biosynthetic process (GO:0006744)3.12720668
81signal transduction involved in DNA damage checkpoint (GO:0072422)3.12282888
82signal transduction involved in DNA integrity checkpoint (GO:0072401)3.12282888
83signal transduction involved in cell cycle checkpoint (GO:0072395)3.08655137
84purine deoxyribonucleotide metabolic process (GO:0009151)3.07123959
85spliceosomal snRNP assembly (GO:0000387)3.05693563
86termination of RNA polymerase III transcription (GO:0006386)3.02521719
87transcription elongation from RNA polymerase III promoter (GO:0006385)3.02521719
88maturation of 5.8S rRNA (GO:0000460)3.01919237
89deoxyribose phosphate biosynthetic process (GO:0046385)2.99797281
902-deoxyribonucleotide biosynthetic process (GO:0009265)2.99797281
91telomere maintenance via semi-conservative replication (GO:0032201)2.98009997
92protein complex disassembly (GO:0043241)2.97709469
93rRNA processing (GO:0006364)2.97704814
94positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.94572633
95pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.93626513
96anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.92482958
97protein deneddylation (GO:0000338)2.91869053
98pentose metabolic process (GO:0019321)2.91818349
99macromolecular complex disassembly (GO:0032984)2.91499054
100purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.90425480

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.12128408
2JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.03085544
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.00337292
4ETS1_20019798_ChIP-Seq_JURKAT_Human3.50282869
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.47694602
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.37420853
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.30660455
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.25849409
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.21234339
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.18742684
11ELF1_17652178_ChIP-ChIP_JURKAT_Human3.05137876
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.98497630
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.71583535
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.67589782
15VDR_23849224_ChIP-Seq_CD4+_Human2.50281903
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.49717988
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.49039634
18THAP11_20581084_ChIP-Seq_MESCs_Mouse2.48228866
19FOXP3_21729870_ChIP-Seq_TREG_Human2.45448045
20GABP_19822575_ChIP-Seq_HepG2_Human2.43869875
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.41506907
22XRN2_22483619_ChIP-Seq_HELA_Human2.37754631
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.36876317
24SRF_21415370_ChIP-Seq_HL-1_Mouse2.35225410
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.17899800
26E2F7_22180533_ChIP-Seq_HELA_Human2.06347667
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.06227322
28CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.02441202
29DCP1A_22483619_ChIP-Seq_HELA_Human1.99400711
30YY1_21170310_ChIP-Seq_MESCs_Mouse1.98142397
31TTF2_22483619_ChIP-Seq_HELA_Human1.93100715
32NELFA_20434984_ChIP-Seq_ESCs_Mouse1.91211759
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.89937593
34ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.82269244
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.81187338
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.81037767
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.76246520
38CIITA_25753668_ChIP-Seq_RAJI_Human1.72221128
39CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.66233544
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.61506417
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56869241
42PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.54691681
43E2F4_17652178_ChIP-ChIP_JURKAT_Human1.54669201
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.54175919
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52541901
46KDM5A_27292631_Chip-Seq_BREAST_Human1.50437223
47BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.50428324
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46825665
49DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.46372771
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45463546
51BP1_19119308_ChIP-ChIP_Hs578T_Human1.40765589
52CTCF_18555785_ChIP-Seq_MESCs_Mouse1.35236386
53SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.33200449
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32549031
55MYC_18940864_ChIP-ChIP_HL60_Human1.31229369
56FOXP1_21924763_ChIP-Seq_HESCs_Human1.31061706
57CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.30737393
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30424354
59ELK1_19687146_ChIP-ChIP_HELA_Human1.30211885
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.29308800
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27759745
62FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.26335554
63POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.26280492
64ELF1_20517297_ChIP-Seq_JURKAT_Human1.25389986
65CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.25154697
66TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24309794
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20110818
68TET1_21451524_ChIP-Seq_MESCs_Mouse1.19657027
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19570954
70SRY_22984422_ChIP-ChIP_TESTIS_Rat1.18989606
71BCL6_27268052_Chip-Seq_Bcells_Human1.18799299
72VDR_21846776_ChIP-Seq_THP-1_Human1.17847081
73YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15392169
74MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13022630
75NOTCH1_21737748_ChIP-Seq_TLL_Human1.12175018
76YY1_22570637_ChIP-Seq_MALME-3M_Human1.11059646
77CTCF_26484167_Chip-Seq_Bcells_Mouse1.10795261
78DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10686169
79MYCN_18555785_ChIP-Seq_MESCs_Mouse1.10527424
80GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09882787
81EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.09141676
82E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08895695
83RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.07531641
84FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04911823
85HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04107176
86P68_20966046_ChIP-Seq_HELA_Human1.03146941
87NANOG_18555785_ChIP-Seq_MESCs_Mouse1.01038092
88BCOR_27268052_Chip-Seq_Bcells_Human1.00068781
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97951130
90E2F1_20622854_ChIP-Seq_HELA_Human0.97619903
91IRF1_19129219_ChIP-ChIP_H3396_Human0.95371823
92SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95338575
93PHF8_20622854_ChIP-Seq_HELA_Human0.94230682
94CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.93577234
95CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93398114
96MAF_26560356_Chip-Seq_TH2_Human0.92353017
97ZNF263_19887448_ChIP-Seq_K562_Human0.92185232
98PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91359188
99PU.1_20513432_ChIP-Seq_Bcells_Mouse0.89668083
100KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.89312166

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.32235048
2MP0008058_abnormal_DNA_repair3.15215317
3MP0009379_abnormal_foot_pigmentation2.97061646
4MP0006292_abnormal_olfactory_placode2.80189550
5MP0005075_abnormal_melanosome_morpholog2.55094657
6MP0000372_irregular_coat_pigmentation2.51019747
7MP0006036_abnormal_mitochondrial_physio2.35727147
8MP0003186_abnormal_redox_activity2.25474710
9MP0002653_abnormal_ependyma_morphology2.23160041
10MP0010094_abnormal_chromosome_stability2.22565316
11MP0003646_muscle_fatigue2.20622578
12MP0001529_abnormal_vocalization2.16356357
13MP0003693_abnormal_embryo_hatching2.15348465
14MP0005646_abnormal_pituitary_gland2.11952568
15MP0003786_premature_aging2.02877929
16MP0003122_maternal_imprinting1.92535512
17MP0008789_abnormal_olfactory_epithelium1.90121876
18MP0001905_abnormal_dopamine_level1.87974047
19MP0003121_genomic_imprinting1.85444667
20MP0002837_dystrophic_cardiac_calcinosis1.84524317
21MP0003880_abnormal_central_pattern1.79657609
22MP0003136_yellow_coat_color1.74866741
23MP0008995_early_reproductive_senescence1.74052547
24MP0005645_abnormal_hypothalamus_physiol1.73373111
25MP0003123_paternal_imprinting1.66572621
26MP0001968_abnormal_touch/_nociception1.65016955
27MP0006035_abnormal_mitochondrial_morpho1.64892290
28MP0008877_abnormal_DNA_methylation1.64120432
29MP0004147_increased_porphyrin_level1.62088662
30MP0006276_abnormal_autonomic_nervous1.54390871
31MP0002277_abnormal_respiratory_mucosa1.52596292
32MP0003111_abnormal_nucleus_morphology1.50213214
33MP0004142_abnormal_muscle_tone1.45314447
34MP0008007_abnormal_cellular_replicative1.43917942
35MP0002736_abnormal_nociception_after1.43675368
36MP0002163_abnormal_gland_morphology1.41720614
37MP0001986_abnormal_taste_sensitivity1.41577020
38MP0003787_abnormal_imprinting1.39148511
39MP0001764_abnormal_homeostasis1.38601606
40MP0008875_abnormal_xenobiotic_pharmacok1.37766972
41MP0002095_abnormal_skin_pigmentation1.37206123
42MP0005394_taste/olfaction_phenotype1.37110904
43MP0005499_abnormal_olfactory_system1.37110904
44MP0001727_abnormal_embryo_implantation1.33267846
45MP0001853_heart_inflammation1.32912883
46MP0004957_abnormal_blastocyst_morpholog1.30567405
47MP0003718_maternal_effect1.28472291
48MP0005671_abnormal_response_to1.27285242
49MP0009333_abnormal_splenocyte_physiolog1.23197801
50MP0002876_abnormal_thyroid_physiology1.22656607
51MP0008872_abnormal_physiological_respon1.19374265
52MP0002160_abnormal_reproductive_system1.19099007
53MP0003077_abnormal_cell_cycle1.15250687
54MP0008932_abnormal_embryonic_tissue1.15067895
55MP0006072_abnormal_retinal_apoptosis1.13906983
56MP0002822_catalepsy1.13568152
57MP0002132_abnormal_respiratory_system1.13149386
58MP0009278_abnormal_bone_marrow1.09126008
59MP0005379_endocrine/exocrine_gland_phen1.04289048
60MP0009046_muscle_twitch1.02804960
61MP0001984_abnormal_olfaction1.02547993
62MP0005389_reproductive_system_phenotype0.99101429
63MP0005423_abnormal_somatic_nervous0.96300500
64MP0005084_abnormal_gallbladder_morpholo0.96079825
65MP0001835_abnormal_antigen_presentation0.93807724
66MP0004858_abnormal_nervous_system0.93378408
67MP0004145_abnormal_muscle_electrophysio0.92465419
68MP0005551_abnormal_eye_electrophysiolog0.92396131
69MP0000631_abnormal_neuroendocrine_gland0.91631935
70MP0005670_abnormal_white_adipose0.91243740
71MP0000015_abnormal_ear_pigmentation0.91171747
72MP0002102_abnormal_ear_morphology0.90889952
73MP0001293_anophthalmia0.90491748
74MP0001919_abnormal_reproductive_system0.89193232
75MP0002148_abnormal_hypersensitivity_rea0.86852740
76MP0005397_hematopoietic_system_phenotyp0.86390643
77MP0001545_abnormal_hematopoietic_system0.86390643
78MP0003315_abnormal_perineum_morphology0.85463237
79MP0005451_abnormal_body_composition0.84626424
80MP0002210_abnormal_sex_determination0.82368212
81MP0005410_abnormal_fertilization0.81433798
82MP0002019_abnormal_tumor_incidence0.80839670
83MP0005636_abnormal_mineral_homeostasis0.80813704
84MP0000313_abnormal_cell_death0.80786238
85MP0000358_abnormal_cell_content/0.79901313
86MP0001929_abnormal_gametogenesis0.78461287
87MP0005266_abnormal_metabolism0.76908823
88MP0001145_abnormal_male_reproductive0.75446429
89MP0000049_abnormal_middle_ear0.73831914
90MP0000689_abnormal_spleen_morphology0.73575944
91MP0004133_heterotaxia0.73290056
92MP0002938_white_spotting0.72852637
93MP0000639_abnormal_adrenal_gland0.71159911
94MP0002398_abnormal_bone_marrow0.70205803
95MP0003011_delayed_dark_adaptation0.69888449
96MP0000653_abnormal_sex_gland0.68005563
97MP0003567_abnormal_fetal_cardiomyocyte0.67899018
98MP0002722_abnormal_immune_system0.67891693
99MP0001661_extended_life_span0.67184073
100MP0001485_abnormal_pinna_reflex0.65767312

Predicted human phenotypes

RankGene SetZ-score
1Abnormal mitochondria in muscle tissue (HP:0008316)5.22398634
2Acute necrotizing encephalopathy (HP:0006965)5.15892990
3Mitochondrial inheritance (HP:0001427)4.94467447
4Hepatocellular necrosis (HP:0001404)4.90143056
5Acute encephalopathy (HP:0006846)4.64674059
6Increased CSF lactate (HP:0002490)4.58292270
7Hepatic necrosis (HP:0002605)4.42975333
8Increased intramyocellular lipid droplets (HP:0012240)4.18117653
9Progressive macrocephaly (HP:0004481)4.14545634
10Microvesicular hepatic steatosis (HP:0001414)4.10632193
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.94346198
12Decreased activity of mitochondrial respiratory chain (HP:0008972)3.94346198
13Abnormality of cells of the erythroid lineage (HP:0012130)3.90029914
14Increased muscle lipid content (HP:0009058)3.88496526
15Abnormal number of erythroid precursors (HP:0012131)3.56832422
16Increased serum lactate (HP:0002151)3.55304549
17Increased hepatocellular lipid droplets (HP:0006565)3.52548365
18Lipid accumulation in hepatocytes (HP:0006561)3.49950309
19Reticulocytopenia (HP:0001896)3.47188460
20Cerebral edema (HP:0002181)3.39865421
21Lactic acidosis (HP:0003128)3.36973876
223-Methylglutaconic aciduria (HP:0003535)3.12871744
23Exercise intolerance (HP:0003546)3.06152946
24Renal Fanconi syndrome (HP:0001994)2.99335879
25Abnormal protein glycosylation (HP:0012346)2.97740676
26Abnormal glycosylation (HP:0012345)2.97740676
27Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.97740676
28Abnormal protein N-linked glycosylation (HP:0012347)2.97740676
29Hyperglycinemia (HP:0002154)2.91958944
30Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.89909231
31Aplasia/Hypoplasia of the sacrum (HP:0008517)2.87116130
32Type I transferrin isoform profile (HP:0003642)2.85251831
33Progressive microcephaly (HP:0000253)2.82515033
34Respiratory failure (HP:0002878)2.70547671
35Aplastic anemia (HP:0001915)2.66682479
36Cerebral hypomyelination (HP:0006808)2.59972372
37Abnormality of dicarboxylic acid metabolism (HP:0010995)2.59308430
38Dicarboxylic aciduria (HP:0003215)2.59308430
39Optic disc pallor (HP:0000543)2.56741361
40Emotional lability (HP:0000712)2.55462066
41Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.54605698
42Lethargy (HP:0001254)2.54009614
43Absent thumb (HP:0009777)2.52196983
44Respiratory difficulties (HP:0002880)2.47759684
45CNS demyelination (HP:0007305)2.43240702
46Failure to thrive in infancy (HP:0001531)2.37664252
47Pancytopenia (HP:0001876)2.34344683
48Ragged-red muscle fibers (HP:0003200)2.30690277
49Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.27157863
50Abnormality of alanine metabolism (HP:0010916)2.27157863
51Hyperalaninemia (HP:0003348)2.27157863
52Macrocytic anemia (HP:0001972)2.26175749
53Microretrognathia (HP:0000308)2.25359514
54Colon cancer (HP:0003003)2.19117854
55Exertional dyspnea (HP:0002875)2.17422018
56Pallor (HP:0000980)2.15883508
57Methylmalonic aciduria (HP:0012120)2.14853789
58Elevated erythrocyte sedimentation rate (HP:0003565)2.14760020
59Leukodystrophy (HP:0002415)2.12063525
60Increased serum pyruvate (HP:0003542)2.08817480
61Septo-optic dysplasia (HP:0100842)2.07313586
62Cerebral palsy (HP:0100021)2.00946319
63Congenital stationary night blindness (HP:0007642)2.00786893
64Absent rod-and cone-mediated responses on ERG (HP:0007688)2.00040273
65Testicular atrophy (HP:0000029)1.97704291
66Panhypogammaglobulinemia (HP:0003139)1.96533179
67Abnormality of renal resorption (HP:0011038)1.90819628
68Tubulointerstitial nephritis (HP:0001970)1.86961056
69Degeneration of anterior horn cells (HP:0002398)1.86810036
70Abnormality of the anterior horn cell (HP:0006802)1.86810036
71Medial flaring of the eyebrow (HP:0010747)1.86804930
72Sclerocornea (HP:0000647)1.85837966
73Thrombocytosis (HP:0001894)1.85257938
74Rhabdomyolysis (HP:0003201)1.84087330
75Abnormal rod and cone electroretinograms (HP:0008323)1.83507247
76Neutropenia (HP:0001875)1.82718908
77Abnormality of glycolysis (HP:0004366)1.81207798
78Decreased electroretinogram (ERG) amplitude (HP:0000654)1.80358374
79IgG deficiency (HP:0004315)1.79226958
80B lymphocytopenia (HP:0010976)1.78493506
81Nephrogenic diabetes insipidus (HP:0009806)1.78458993
82Increased IgM level (HP:0003496)1.78382209
83Hyperglycinuria (HP:0003108)1.78119861
84Rib fusion (HP:0000902)1.76533575
85Reduced antithrombin III activity (HP:0001976)1.76227842
86Aplasia/hypoplasia of the uterus (HP:0008684)1.75864083
87Gliosis (HP:0002171)1.75386970
88Abnormality of B cell number (HP:0010975)1.73905561
89Opisthotonus (HP:0002179)1.72693952
90Abnormality of serine family amino acid metabolism (HP:0010894)1.71770392
91Abnormality of glycine metabolism (HP:0010895)1.71770392
92Severe combined immunodeficiency (HP:0004430)1.71183063
93Multiple enchondromatosis (HP:0005701)1.70340989
94Atrophy/Degeneration involving motor neurons (HP:0007373)1.69184264
95Flat capital femoral epiphysis (HP:0003370)1.68296546
96Hyperthyroidism (HP:0000836)1.68081901
97Abnormality of serum amino acid levels (HP:0003112)1.68014666
98Methylmalonic acidemia (HP:0002912)1.66111262
99Hypoplasia of the uterus (HP:0000013)1.65619325
100Congenital primary aphakia (HP:0007707)1.65468434

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.56093945
2BCKDK4.14069795
3TESK23.95731612
4NME23.70922084
5MAP4K22.87474340
6STK162.81995679
7KDR2.72390124
8PIM22.48449058
9SRPK12.31698139
10ZAK2.22804477
11TESK12.15916856
12CDC72.02285483
13VRK11.98480057
14BUB11.88356815
15TLK11.80885250
16LIMK11.68764719
17TAOK31.67767912
18ARAF1.67123307
19SCYL21.60302879
20NUAK11.54111547
21CSNK1G31.51234539
22MAP3K111.50257123
23PINK11.43053460
24MAP2K71.35909144
25CDK191.32983867
26DYRK21.24652623
27ABL21.21632606
28RPS6KA41.17485848
29DAPK11.15561825
30CSNK1G21.14492016
31MAP4K11.13239802
32CSNK1A1L1.13123482
33MAP3K121.12814428
34CCNB11.08346785
35PDK21.07987024
36ATR1.06545706
37PBK1.05968133
38LRRK21.05760091
39EIF2AK11.02684994
40RPS6KA51.01691544
41AURKA1.00910816
42CSNK1G10.97147317
43TNK20.91523632
44FLT30.89565239
45NME10.83907764
46CDK80.78929353
47PLK10.78909738
48DAPK30.77615263
49AURKB0.76335032
50GRK60.74823525
51CHEK20.74813808
52PIM10.73319625
53PLK40.72894458
54CSNK2A20.71961344
55ADRBK20.70708081
56BMPR1B0.70041141
57CSF1R0.69284391
58WNK40.68616367
59TXK0.68587133
60GRK10.67769765
61TEC0.66333909
62NEK10.66115756
63CSNK2A10.63147213
64PRKCQ0.60697051
65MAPKAPK30.60115253
66IKBKB0.59434066
67EPHA40.59218267
68ERN10.58662616
69RPS6KB20.52887901
70CDK70.51725881
71TBK10.50911053
72KIT0.49885681
73MST40.49611181
74PRKCI0.48771948
75RAF10.48764615
76BCR0.47932494
77BTK0.47769854
78PLK30.46304762
79CSNK1A10.45926630
80TRIM280.45585779
81TAF10.44171388
82MAP3K50.41863545
83PAK10.39612091
84CHEK10.37945484
85DYRK30.37117111
86GRK50.35661568
87DYRK1B0.34485182
88TIE10.34240036
89SYK0.33864755
90CDK140.33249960
91MAPK130.33133820
92AKT20.33114107
93CAMK10.32982118
94LYN0.32093030
95ITK0.31562490
96MAP2K20.31533663
97BRAF0.31345844
98LCK0.30965052
99TAOK20.29523413
100PRKCD0.28834919

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.32813159
2Proteasome_Homo sapiens_hsa030504.18870538
3Oxidative phosphorylation_Homo sapiens_hsa001903.92754546
4Parkinsons disease_Homo sapiens_hsa050123.46920889
5DNA replication_Homo sapiens_hsa030303.12056282
6Base excision repair_Homo sapiens_hsa034102.92171689
7Sulfur relay system_Homo sapiens_hsa041222.82280827
8RNA polymerase_Homo sapiens_hsa030202.64386399
9Huntingtons disease_Homo sapiens_hsa050162.40017161
10Homologous recombination_Homo sapiens_hsa034402.26537202
11Alzheimers disease_Homo sapiens_hsa050102.22810162
12Mismatch repair_Homo sapiens_hsa034302.18598534
13Pyrimidine metabolism_Homo sapiens_hsa002402.08855443
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.04741215
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.01878245
16Spliceosome_Homo sapiens_hsa030402.00201863
17Protein export_Homo sapiens_hsa030601.96891834
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.94241799
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.88500735
20Fanconi anemia pathway_Homo sapiens_hsa034601.74654243
21Nucleotide excision repair_Homo sapiens_hsa034201.57448600
22Primary immunodeficiency_Homo sapiens_hsa053401.51608060
23Cardiac muscle contraction_Homo sapiens_hsa042601.50926069
24Fatty acid elongation_Homo sapiens_hsa000621.47137502
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38488432
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.37958705
27One carbon pool by folate_Homo sapiens_hsa006701.31805246
28Non-homologous end-joining_Homo sapiens_hsa034501.30945135
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30210346
30Sulfur metabolism_Homo sapiens_hsa009201.26543638
31Asthma_Homo sapiens_hsa053101.26532207
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.26155044
33RNA degradation_Homo sapiens_hsa030181.23789668
34Folate biosynthesis_Homo sapiens_hsa007901.23183012
35RNA transport_Homo sapiens_hsa030131.16792326
36Purine metabolism_Homo sapiens_hsa002301.12591255
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10473947
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.09427664
39Peroxisome_Homo sapiens_hsa041461.06118278
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00347726
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.99269450
42Cysteine and methionine metabolism_Homo sapiens_hsa002700.96083450
43Glutathione metabolism_Homo sapiens_hsa004800.94561782
44Basal transcription factors_Homo sapiens_hsa030220.92628964
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90550479
46Allograft rejection_Homo sapiens_hsa053300.90275608
47Metabolic pathways_Homo sapiens_hsa011000.88860364
48Carbon metabolism_Homo sapiens_hsa012000.88209391
49Autoimmune thyroid disease_Homo sapiens_hsa053200.85737654
50Biosynthesis of amino acids_Homo sapiens_hsa012300.85458178
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83635444
52Pyruvate metabolism_Homo sapiens_hsa006200.80828046
53Propanoate metabolism_Homo sapiens_hsa006400.80472678
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80295769
55Systemic lupus erythematosus_Homo sapiens_hsa053220.79720757
56N-Glycan biosynthesis_Homo sapiens_hsa005100.74496453
57Phototransduction_Homo sapiens_hsa047440.71744169
58Butanoate metabolism_Homo sapiens_hsa006500.71613685
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70837456
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.68821416
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.66749224
62Graft-versus-host disease_Homo sapiens_hsa053320.65141972
63Collecting duct acid secretion_Homo sapiens_hsa049660.59493921
64Pentose phosphate pathway_Homo sapiens_hsa000300.57149227
65Type I diabetes mellitus_Homo sapiens_hsa049400.56133882
66Antigen processing and presentation_Homo sapiens_hsa046120.55730655
67Arginine and proline metabolism_Homo sapiens_hsa003300.55010455
68Steroid biosynthesis_Homo sapiens_hsa001000.54438158
69Epstein-Barr virus infection_Homo sapiens_hsa051690.50307467
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47198722
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.46313969
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45829155
73Selenocompound metabolism_Homo sapiens_hsa004500.45092916
74Rheumatoid arthritis_Homo sapiens_hsa053230.43151493
75Regulation of autophagy_Homo sapiens_hsa041400.42586029
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40362841
77Tryptophan metabolism_Homo sapiens_hsa003800.37394625
78Herpes simplex infection_Homo sapiens_hsa051680.36346262
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33807232
80Fatty acid metabolism_Homo sapiens_hsa012120.32730477
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32021975
82Vitamin B6 metabolism_Homo sapiens_hsa007500.30766767
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30539256
84Tyrosine metabolism_Homo sapiens_hsa003500.30451601
85Phenylalanine metabolism_Homo sapiens_hsa003600.27588590
86Alcoholism_Homo sapiens_hsa050340.27141617
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.26474621
88Synaptic vesicle cycle_Homo sapiens_hsa047210.25081995
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24391311
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.23815119
91Cell cycle_Homo sapiens_hsa041100.22852427
92mRNA surveillance pathway_Homo sapiens_hsa030150.22784925
93Viral myocarditis_Homo sapiens_hsa054160.22643206
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.22039368
95p53 signaling pathway_Homo sapiens_hsa041150.21893404
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21491873
97Hematopoietic cell lineage_Homo sapiens_hsa046400.18147958
98Arachidonic acid metabolism_Homo sapiens_hsa005900.17107480
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.16881150
100Vibrio cholerae infection_Homo sapiens_hsa051100.16151229

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