NCAM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein and may function in selective fasciculation and zone-to-zone projection of the primary olfactory axons. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* neuron cell-cell adhesion (GO:0007158)5.59730242
2axon ensheathment in central nervous system (GO:0032291)5.07634329
3central nervous system myelination (GO:0022010)5.07634329
4presynaptic membrane assembly (GO:0097105)4.84888502
5sodium ion export (GO:0071436)4.73629788
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.70563277
7locomotory exploration behavior (GO:0035641)4.65436732
8regulation of short-term neuronal synaptic plasticity (GO:0048172)4.56254232
9vocalization behavior (GO:0071625)4.54038785
10presynaptic membrane organization (GO:0097090)4.50885560
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.39995543
12neuronal action potential propagation (GO:0019227)4.39050012
13synaptic vesicle maturation (GO:0016188)4.32134833
14protein localization to synapse (GO:0035418)4.25565228
15synaptic vesicle exocytosis (GO:0016079)4.20301278
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.16935301
17cerebellar Purkinje cell layer development (GO:0021680)4.14765904
18glutamate secretion (GO:0014047)4.02883841
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.00876140
20regulation of synaptic vesicle exocytosis (GO:2000300)3.91197541
21postsynaptic membrane organization (GO:0001941)3.89647439
22dendritic spine morphogenesis (GO:0060997)3.87166039
23regulation of glutamate receptor signaling pathway (GO:1900449)3.82651172
24L-amino acid import (GO:0043092)3.77007263
25gamma-aminobutyric acid transport (GO:0015812)3.76875561
26glutamate receptor signaling pathway (GO:0007215)3.76096010
27synaptic transmission, glutamatergic (GO:0035249)3.75969654
28* neuron recognition (GO:0008038)3.74169907
29neuron-neuron synaptic transmission (GO:0007270)3.74123881
30potassium ion homeostasis (GO:0055075)3.71768729
31exploration behavior (GO:0035640)3.68522558
32neurotransmitter-gated ion channel clustering (GO:0072578)3.66424289
33transmission of nerve impulse (GO:0019226)3.56026081
34negative regulation of neurotransmitter transport (GO:0051589)3.55372749
35synaptic vesicle endocytosis (GO:0048488)3.50753138
36gamma-aminobutyric acid signaling pathway (GO:0007214)3.50525272
37regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.47727673
38regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.46307251
39regulation of neuronal synaptic plasticity (GO:0048168)3.45161822
40long-chain fatty acid biosynthetic process (GO:0042759)3.42735414
41neurotransmitter uptake (GO:0001504)3.40682380
42positive regulation of synapse maturation (GO:0090129)3.39651251
43regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.37873460
44potassium ion import (GO:0010107)3.36330846
45regulation of long-term neuronal synaptic plasticity (GO:0048169)3.34702934
46cerebellar granule cell differentiation (GO:0021707)3.33766794
47* axonal fasciculation (GO:0007413)3.33318157
48positive regulation of membrane potential (GO:0045838)3.32328965
49neurotransmitter secretion (GO:0007269)3.30859001
50negative regulation of synaptic transmission, GABAergic (GO:0032229)3.30042984
51cellular sodium ion homeostasis (GO:0006883)3.29973290
52acidic amino acid transport (GO:0015800)3.29704233
53regulation of synaptic vesicle transport (GO:1902803)3.29592242
54dendrite morphogenesis (GO:0048813)3.28991537
55layer formation in cerebral cortex (GO:0021819)3.27991669
56regulation of excitatory postsynaptic membrane potential (GO:0060079)3.26347071
57startle response (GO:0001964)3.25732340
58positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.24689010
59positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.24166647
60synapse assembly (GO:0007416)3.22048191
61long-term memory (GO:0007616)3.21872394
62auditory behavior (GO:0031223)3.20697554
63cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.20238235
64negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.18517723
65establishment of mitochondrion localization (GO:0051654)3.16405685
66negative regulation of neurotransmitter secretion (GO:0046929)3.16162586
67membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.13016266
68regulation of synaptic transmission, glutamatergic (GO:0051966)3.12297502
69regulation of postsynaptic membrane potential (GO:0060078)3.11686893
70myelination (GO:0042552)3.11160607
71regulation of synapse structural plasticity (GO:0051823)3.10969960
72neuromuscular process controlling balance (GO:0050885)3.08872789
73long-term synaptic potentiation (GO:0060291)3.06346502
74regulation of dendritic spine morphogenesis (GO:0061001)3.06339661
75establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.05458686
76mitochondrion transport along microtubule (GO:0047497)3.05458686
77adult walking behavior (GO:0007628)3.05350664
78ensheathment of neurons (GO:0007272)3.05244988
79axon ensheathment (GO:0008366)3.05244988
80positive regulation of dendritic spine morphogenesis (GO:0061003)3.04326462
81amino acid import (GO:0043090)3.03603845
82positive regulation of synapse assembly (GO:0051965)3.01434465
83synaptic vesicle docking involved in exocytosis (GO:0016081)2.99846610
84mechanosensory behavior (GO:0007638)2.99495933
85regulation of dendritic spine development (GO:0060998)2.97157652
86membrane hyperpolarization (GO:0060081)2.96983842
87neurotransmitter transport (GO:0006836)2.96577119
88L-glutamate transport (GO:0015813)2.95886897
89response to auditory stimulus (GO:0010996)2.94267411
90positive regulation of dendritic spine development (GO:0060999)2.94119184
91G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.93651197
92regulation of synaptic plasticity (GO:0048167)2.91863489
93regulation of ARF protein signal transduction (GO:0032012)2.90730279
94righting reflex (GO:0060013)2.90088530
95negative regulation of dendrite morphogenesis (GO:0050774)2.89417312
96regulation of neurotransmitter secretion (GO:0046928)2.88498149
97regulation of respiratory system process (GO:0044065)2.85985619
98membrane depolarization during action potential (GO:0086010)2.85795370
99response to histamine (GO:0034776)2.85791159
100cerebral cortex radially oriented cell migration (GO:0021799)2.85293802
101cell differentiation in hindbrain (GO:0021533)2.84979404
102neuronal ion channel clustering (GO:0045161)2.84609926
103C4-dicarboxylate transport (GO:0015740)2.84565543
104synapse organization (GO:0050808)2.84111319
105cell communication by electrical coupling (GO:0010644)2.83806326
106behavioral response to cocaine (GO:0048148)2.83679273
107dendrite development (GO:0016358)2.82464526
108positive regulation of synaptic transmission, GABAergic (GO:0032230)2.80092969
109negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.79700221
110central nervous system projection neuron axonogenesis (GO:0021952)2.79561879
111activation of protein kinase A activity (GO:0034199)2.79164734
112regulation of voltage-gated calcium channel activity (GO:1901385)2.76359620
113learning (GO:0007612)2.76107951
114membrane depolarization (GO:0051899)2.75741058
115synaptic vesicle transport (GO:0048489)2.74673639
116establishment of synaptic vesicle localization (GO:0097480)2.74673639
117mating behavior (GO:0007617)2.73903719
118regulation of synaptic transmission (GO:0050804)2.73425248
119cellular potassium ion homeostasis (GO:0030007)2.72931028
120neuromuscular process (GO:0050905)2.72814344
121synaptic transmission (GO:0007268)2.71650563
122regulation of neurotransmitter transport (GO:0051588)2.71585157
123fatty acid elongation (GO:0030497)2.71395461
124regulation of respiratory gaseous exchange (GO:0043576)2.69229519
125cerebellar Purkinje cell differentiation (GO:0021702)2.68290707
126regulation of synaptic transmission, GABAergic (GO:0032228)2.66404784
127regulation of neurotransmitter levels (GO:0001505)2.65948373
128regulation of vesicle fusion (GO:0031338)2.64504652

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.31873624
2GBX2_23144817_ChIP-Seq_PC3_Human3.99681125
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.95077075
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.90108777
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.87901409
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.51282261
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.51282261
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.47221701
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.47141481
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.42950677
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.35967812
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.35619792
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.32000421
14TAF15_26573619_Chip-Seq_HEK293_Human2.29297800
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.28616415
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.24832067
17ESR1_20079471_ChIP-ChIP_T-47D_Human2.23489063
18AR_21572438_ChIP-Seq_LNCaP_Human2.20937818
19* REST_21632747_ChIP-Seq_MESCs_Mouse2.13373607
20DROSHA_22980978_ChIP-Seq_HELA_Human2.06914698
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.06440211
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.04650858
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.04624407
24* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00493454
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00220721
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99365973
27* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89377635
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.84785264
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.79928872
30* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72590175
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71926495
32SMAD4_21799915_ChIP-Seq_A2780_Human1.71422994
33P300_19829295_ChIP-Seq_ESCs_Human1.70669012
34RARB_27405468_Chip-Seq_BRAIN_Mouse1.70224233
35* CBX2_27304074_Chip-Seq_ESCs_Mouse1.65759465
36ESR2_21235772_ChIP-Seq_MCF-7_Human1.62958004
37* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62342063
38* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61004087
39REST_18959480_ChIP-ChIP_MESCs_Mouse1.60714126
40* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59606197
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.59053266
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.54618396
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.54239521
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.53429711
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.51497091
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.49733990
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47219670
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47150300
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43261083
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40662739
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37233718
52FUS_26573619_Chip-Seq_HEK293_Human1.35534602
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.35261976
54STAT3_23295773_ChIP-Seq_U87_Human1.34693211
55ER_23166858_ChIP-Seq_MCF-7_Human1.32739284
56IGF1R_20145208_ChIP-Seq_DFB_Human1.32144153
57* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29880871
58TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28998536
59* CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.28477470
60RNF2_27304074_Chip-Seq_NSC_Mouse1.27737151
61* SOX2_21211035_ChIP-Seq_LN229_Gbm1.26440369
62RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.23379630
63RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.22379599
64* AR_25329375_ChIP-Seq_VCAP_Human1.21374106
65ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.21183302
66NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21144214
67* SOX9_26525672_Chip-Seq_HEART_Mouse1.20810718
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.20780316
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.18951973
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17636796
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.17609214
72AHR_22903824_ChIP-Seq_MCF-7_Human1.17499080
73* TCF4_23295773_ChIP-Seq_U87_Human1.17445532
74RING1B_27294783_Chip-Seq_ESCs_Mouse1.17028121
75ERG_21242973_ChIP-ChIP_JURKAT_Human1.15776931
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14983515
77TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14731648
78* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14629920
79ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13705219
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13270588
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13170590
82MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.12321374
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.11419867
84RUNX2_22187159_ChIP-Seq_PCA_Human1.10802808
85P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10732541
86ZNF274_21170338_ChIP-Seq_K562_Hela1.10205602
87RING1B_27294783_Chip-Seq_NPCs_Mouse1.08614353
88TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07965520
89TP53_16413492_ChIP-PET_HCT116_Human1.06343964
90AR_19668381_ChIP-Seq_PC3_Human1.06127463
91VDR_22108803_ChIP-Seq_LS180_Human1.06127383
92TP53_18474530_ChIP-ChIP_U2OS_Human1.04135720
93POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04005076
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04005076
95GATA1_26923725_Chip-Seq_HPCs_Mouse1.03494750
96PRDM14_20953172_ChIP-Seq_ESCs_Human1.03232813
97* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03219276
98ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03207680
99CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02376293
100DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02101853
101RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00277608
102MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99899950
103YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99665000
104EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98338131
105CMYC_18555785_Chip-Seq_ESCs_Mouse0.97440234
106E2F1_18555785_Chip-Seq_ESCs_Mouse0.97249734
107ESR1_21235772_ChIP-Seq_MCF-7_Human0.97148214
108PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95874746
109* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95601312
110LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95300412
111* JUN_21703547_ChIP-Seq_K562_Human0.95107856
112CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.94426914
113WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93720674
114STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93361745
115SMAD4_21741376_ChIP-Seq_HESCs_Human0.92622728
116CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.92475155
117PKCTHETA_26484144_Chip-Seq_BREAST_Human0.92176792
118TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91327431
119* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90149908
120ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.85284746

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.97756443
2MP0004859_abnormal_synaptic_plasticity4.90337673
3MP0004270_analgesia3.69789123
4MP0003635_abnormal_synaptic_transmissio3.57115924
5MP0009745_abnormal_behavioral_response3.12266457
6MP0002064_seizures3.01403430
7MP0001486_abnormal_startle_reflex2.91316853
8MP0002063_abnormal_learning/memory/cond2.86308408
9MP0009046_muscle_twitch2.86157688
10MP0005423_abnormal_somatic_nervous2.83405598
11MP0002272_abnormal_nervous_system2.72546628
12MP0002572_abnormal_emotion/affect_behav2.64548279
13MP0001968_abnormal_touch/_nociception2.55710553
14MP0002734_abnormal_mechanical_nocicepti2.55426401
15MP0002822_catalepsy2.35291119
16MP0000778_abnormal_nervous_system2.32127311
17MP0000920_abnormal_myelination2.13974668
18MP0002735_abnormal_chemical_nociception2.12685711
19MP0001984_abnormal_olfaction2.12522497
20MP0001440_abnormal_grooming_behavior2.11546212
21MP0003329_amyloid_beta_deposits2.06956941
22MP0001529_abnormal_vocalization2.03306109
23MP0002067_abnormal_sensory_capabilities1.99904616
24MP0002736_abnormal_nociception_after1.89198209
25MP0004885_abnormal_endolymph1.87212103
26MP0005645_abnormal_hypothalamus_physiol1.83854819
27MP0001970_abnormal_pain_threshold1.83600399
28MP0001501_abnormal_sleep_pattern1.83302286
29MP0004742_abnormal_vestibular_system1.79898860
30MP0002733_abnormal_thermal_nociception1.79134833
31MP0002184_abnormal_innervation1.77421340
32MP0002557_abnormal_social/conspecific_i1.75909980
33MP0006276_abnormal_autonomic_nervous1.73796058
34MP0001905_abnormal_dopamine_level1.73038234
35MP0005386_behavior/neurological_phenoty1.72612554
36MP0004924_abnormal_behavior1.72612554
37MP0005646_abnormal_pituitary_gland1.68769582
38MP0008569_lethality_at_weaning1.68093972
39MP0004142_abnormal_muscle_tone1.67928967
40MP0003123_paternal_imprinting1.63715816
41MP0003690_abnormal_glial_cell1.62610820
42MP0000955_abnormal_spinal_cord1.59710088
43MP0002882_abnormal_neuron_morphology1.56569828
44MP0004858_abnormal_nervous_system1.55982444
45MP0002066_abnormal_motor_capabilities/c1.43660574
46MP0004811_abnormal_neuron_physiology1.39726113
47MP0003633_abnormal_nervous_system1.38921212
48MP0005551_abnormal_eye_electrophysiolog1.38419331
49MP0003634_abnormal_glial_cell1.35110143
50MP0001485_abnormal_pinna_reflex1.31197039
51MP0009780_abnormal_chondrocyte_physiolo1.30330481
52MP0003631_nervous_system_phenotype1.29244282
53MP0005171_absent_coat_pigmentation1.28157242
54MP0005409_darkened_coat_color1.25963089
55MP0001346_abnormal_lacrimal_gland1.24757171
56MP0003136_yellow_coat_color1.24188974
57MP0002229_neurodegeneration1.22850736
58MP0005248_abnormal_Harderian_gland1.22022306
59MP0001963_abnormal_hearing_physiology1.21422499
60MP0001502_abnormal_circadian_rhythm1.18328658
61MP0004233_abnormal_muscle_weight1.15441828
62MP0004147_increased_porphyrin_level1.13838029
63MP0003632_abnormal_nervous_system1.13356249
64* MP0002152_abnormal_brain_morphology1.13338881
65MP0003122_maternal_imprinting1.11632228
66MP0002752_abnormal_somatic_nervous1.10914993
67MP0003879_abnormal_hair_cell1.07402112
68MP0000569_abnormal_digit_pigmentation1.07302263
69MP0001188_hyperpigmentation1.06250084
70MP0003121_genomic_imprinting1.03647666
71MP0004145_abnormal_muscle_electrophysio0.98226051
72MP0000537_abnormal_urethra_morphology0.97275572
73MP0010234_abnormal_vibrissa_follicle0.96277266
74MP0000631_abnormal_neuroendocrine_gland0.95553856
75MP0002909_abnormal_adrenal_gland0.94596391
76MP0000604_amyloidosis0.92109470
77MP0005187_abnormal_penis_morphology0.91896437
78MP0002009_preneoplasia0.90466993
79MP0003787_abnormal_imprinting0.89777578
80MP0001299_abnormal_eye_distance/0.89024875
81MP0000579_abnormal_nail_morphology0.89010891
82MP0001177_atelectasis0.85220026
83MP0002069_abnormal_eating/drinking_beha0.83920513
84MP0000026_abnormal_inner_ear0.81413738
85MP0004085_abnormal_heartbeat0.79383499
86MP0000427_abnormal_hair_cycle0.78179557
87MP0000462_abnormal_digestive_system0.77648979
88MP0002638_abnormal_pupillary_reflex0.75770387
89MP0008874_decreased_physiological_sensi0.73232110
90MP0005623_abnormal_meninges_morphology0.73230640
91MP0005394_taste/olfaction_phenotype0.73148544
92MP0005499_abnormal_olfactory_system0.73148544
93MP0003011_delayed_dark_adaptation0.73095733
94MP0010386_abnormal_urinary_bladder0.72850191
95MP0005379_endocrine/exocrine_gland_phen0.72726639
96MP0002653_abnormal_ependyma_morphology0.71276927
97MP0001664_abnormal_digestion0.71065898
98MP0008872_abnormal_physiological_respon0.70831256
99MP0005195_abnormal_posterior_eye0.66173506
100MP0003137_abnormal_impulse_conducting0.65717237
101MP0003861_abnormal_nervous_system0.65478022
102MP0000751_myopathy0.64709356
103MP0002090_abnormal_vision0.63693146
104MP0005253_abnormal_eye_physiology0.63461213
105MP0001943_abnormal_respiration0.62984751
106MP0002751_abnormal_autonomic_nervous0.62750077
107MP0004134_abnormal_chest_morphology0.62510535
108MP0000534_abnormal_ureter_morphology0.61478232
109MP0003938_abnormal_ear_development0.60929858
110MP0001919_abnormal_reproductive_system0.59757036
111MP0002102_abnormal_ear_morphology0.59611982
112MP0002249_abnormal_larynx_morphology0.58584396
113MP0000566_synostosis0.58351493
114MP0005410_abnormal_fertilization0.57214379
115MP0010769_abnormal_survival0.57150603
116MP0000383_abnormal_hair_follicle0.55485070
117MP0008260_abnormal_autophagy0.54894101
118MP0010678_abnormal_skin_adnexa0.54348031
119MP0010770_preweaning_lethality0.53838701
120MP0002082_postnatal_lethality0.53838701
121MP0006072_abnormal_retinal_apoptosis0.53088429

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.30411155
2Myokymia (HP:0002411)5.61548932
3Focal seizures (HP:0007359)4.71824781
4Degeneration of the lateral corticospinal tracts (HP:0002314)4.36692386
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.36692386
6Epileptic encephalopathy (HP:0200134)4.27388418
7Atonic seizures (HP:0010819)4.08268003
8Abnormality of the corticospinal tract (HP:0002492)4.06759071
9Hyperventilation (HP:0002883)3.80387302
10Progressive cerebellar ataxia (HP:0002073)3.77072753
11Neurofibrillary tangles (HP:0002185)3.71334520
12Febrile seizures (HP:0002373)3.57661918
13Broad-based gait (HP:0002136)3.53752929
14Termporal pattern (HP:0011008)3.44340468
15Insidious onset (HP:0003587)3.44340468
16Spastic gait (HP:0002064)3.34771001
17Ankle clonus (HP:0011448)3.34087154
18Action tremor (HP:0002345)3.31536585
19Absence seizures (HP:0002121)3.31315239
20Visual hallucinations (HP:0002367)3.25339937
21Supranuclear gaze palsy (HP:0000605)3.24332020
22Dialeptic seizures (HP:0011146)3.21514818
23Generalized tonic-clonic seizures (HP:0002069)3.18922226
24Dysmetria (HP:0001310)3.12685651
25Gaze-evoked nystagmus (HP:0000640)3.01561343
26Cerebral inclusion bodies (HP:0100314)2.99364895
27Scanning speech (HP:0002168)2.85152699
28Retinal dysplasia (HP:0007973)2.84087795
29Drooling (HP:0002307)2.82285296
30Excessive salivation (HP:0003781)2.82285296
31Urinary bladder sphincter dysfunction (HP:0002839)2.80566016
32Impaired vibration sensation in the lower limbs (HP:0002166)2.74899615
33Dysdiadochokinesis (HP:0002075)2.74825321
34Intention tremor (HP:0002080)2.71480724
35Progressive inability to walk (HP:0002505)2.71070912
36Truncal ataxia (HP:0002078)2.65986671
37Absent speech (HP:0001344)2.62835852
38Peripheral hypomyelination (HP:0007182)2.61965910
39Obstructive sleep apnea (HP:0002870)2.61168248
40Sparse lateral eyebrow (HP:0005338)2.56565715
41Pheochromocytoma (HP:0002666)2.56119731
42Dysmetric saccades (HP:0000641)2.55278130
43Blue irides (HP:0000635)2.54024646
44Hemiplegia (HP:0002301)2.49948799
45Poor eye contact (HP:0000817)2.49121745
46Limb dystonia (HP:0002451)2.45946195
47Lower limb muscle weakness (HP:0007340)2.45688723
48Urinary urgency (HP:0000012)2.43132653
49Abnormal eating behavior (HP:0100738)2.42912268
50Sensory axonal neuropathy (HP:0003390)2.37060795
51Postural instability (HP:0002172)2.35793453
52Hemiparesis (HP:0001269)2.35050626
53Mutism (HP:0002300)2.32948988
54Anxiety (HP:0000739)2.32003383
55Dynein arm defect of respiratory motile cilia (HP:0012255)2.31724995
56Absent/shortened dynein arms (HP:0200106)2.31724995
57Papilledema (HP:0001085)2.30501451
58Status epilepticus (HP:0002133)2.29961096
59Epileptiform EEG discharges (HP:0011182)2.29685943
60Generalized myoclonic seizures (HP:0002123)2.25618291
61EEG with generalized epileptiform discharges (HP:0011198)2.20645641
62Hammertoe (HP:0001765)2.20012567
63Abnormal social behavior (HP:0012433)2.19414729
64Impaired social interactions (HP:0000735)2.19414729
65Aplasia involving bones of the extremities (HP:0009825)2.19003312
66Aplasia involving bones of the upper limbs (HP:0009823)2.19003312
67Aplasia of the phalanges of the hand (HP:0009802)2.19003312
68Polyphagia (HP:0002591)2.18929536
69Amblyopia (HP:0000646)2.18002544
70Onion bulb formation (HP:0003383)2.17091451
71Neuroendocrine neoplasm (HP:0100634)2.16285369
72Abnormality of salivation (HP:0100755)2.15889192
73Papillary thyroid carcinoma (HP:0002895)2.13088760
74Akinesia (HP:0002304)2.13064402
75Sleep apnea (HP:0010535)2.11875916
76Concave nail (HP:0001598)2.11094464
77Clumsiness (HP:0002312)2.08722946
78Hypsarrhythmia (HP:0002521)2.08449777
79Gait imbalance (HP:0002141)2.08007732
80Alacrima (HP:0000522)2.07742078
81Megalencephaly (HP:0001355)2.07017080
82Inability to walk (HP:0002540)2.04944276
83Aqueductal stenosis (HP:0002410)2.04593433
84Germ cell neoplasia (HP:0100728)2.00412760
85Depression (HP:0000716)2.00060399
86Widely spaced teeth (HP:0000687)1.98868586
87Agitation (HP:0000713)1.96285284
88Thickened helices (HP:0000391)1.95221164
89Abnormal ciliary motility (HP:0012262)1.92516975
90Diplopia (HP:0000651)1.92372915
91Abnormality of binocular vision (HP:0011514)1.92372915
92Neuronal loss in central nervous system (HP:0002529)1.91753383
93Impaired smooth pursuit (HP:0007772)1.90672936
94Fair hair (HP:0002286)1.90272897
95Specific learning disability (HP:0001328)1.89999844
96Stereotypic behavior (HP:0000733)1.89406787
97Sensorimotor neuropathy (HP:0007141)1.86247082
98Hypoplasia of the corpus callosum (HP:0002079)1.84724568
99Fetal akinesia sequence (HP:0001989)1.84206499
100Clonus (HP:0002169)1.82855893
101Impaired vibratory sensation (HP:0002495)1.82076308
102Genetic anticipation (HP:0003743)1.81865918
103Torticollis (HP:0000473)1.81465762
104Protruding tongue (HP:0010808)1.81397250
105Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.80403144
106Genital tract atresia (HP:0001827)1.80118913
107Morphological abnormality of the pyramidal tract (HP:0002062)1.79284864
108Limb ataxia (HP:0002070)1.78061102
109Abnormality of saccadic eye movements (HP:0000570)1.77301997
110Spastic tetraparesis (HP:0001285)1.76439277
111Abnormality of the parathyroid morphology (HP:0011766)1.76095312
112Abnormal hair whorl (HP:0010721)1.75861974
113Insomnia (HP:0100785)1.75769532
114Esotropia (HP:0000565)1.75110513
115Diminished movement (HP:0002374)1.75000799
116Spastic tetraplegia (HP:0002510)1.73997220
117Vaginal atresia (HP:0000148)1.72762885
118Generalized hypopigmentation of hair (HP:0011358)1.72745994
119Anosmia (HP:0000458)1.71526560
120Exotropia (HP:0000577)1.71121795
121Abnormality of ocular smooth pursuit (HP:0000617)1.70884653
122Hypothermia (HP:0002045)1.70538595
123Gait ataxia (HP:0002066)1.70252512
124Postural tremor (HP:0002174)1.69596534
125Abnormality of the lower motor neuron (HP:0002366)1.68720341
126Amyotrophic lateral sclerosis (HP:0007354)1.67721484
127Paraplegia (HP:0010550)1.66476660
128Spastic paraplegia (HP:0001258)1.60552690
129Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.60213523
130Cerebral hypomyelination (HP:0006808)1.57221040

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.60499439
2CASK3.45123866
3MARK13.42094909
4EPHA43.08860816
5STK392.76480183
6OXSR12.64399196
7MAP3K42.56915386
8TNIK2.41246291
9MAP2K72.25598619
10NTRK12.19223224
11NTRK22.18993265
12MAP3K92.16694005
13CDK192.01996512
14PNCK1.91273597
15MINK11.89392063
16PAK61.79390674
17MAPK131.78932876
18PRPF4B1.56722801
19PKN11.52981974
20DAPK21.47027241
21CAMK1D1.44219841
22UHMK11.41983292
23CDK51.36703855
24MAP2K41.36206026
25TYRO31.32489221
26PHKG21.31361740
27PHKG11.31361740
28LATS21.30578293
29SGK2231.30152504
30SGK4941.30152504
31NEK61.28611755
32FGFR21.24880766
33PLK21.24054582
34FES1.23027132
35CAMK2B1.21371983
36WNK11.19386989
37BCR1.17510576
38CAMK2A1.17338807
39CSNK1G21.16751825
40TRIB31.12423502
41GRK51.11279038
42SCYL21.11260005
43PAK31.09735922
44FER1.08903368
45TNK21.05593794
46MAP3K121.04668791
47MAPKAPK51.04077527
48CAMK1G0.99839865
49MUSK0.98929087
50WNK40.98321353
51KSR10.96374344
52CAMKK20.96361159
53PRKCG0.95023949
54CCNB10.93612780
55EEF2K0.92841059
56KSR20.92517231
57CSNK1G30.92386128
58PKN20.91413145
59FGR0.90235972
60CSNK1A1L0.88927905
61TSSK60.86239224
62RIPK40.85201631
63CDK140.84324036
64MARK20.84102401
65CAMK2D0.83863509
66EPHB10.83104140
67CDK180.82074168
68CAMKK10.80283379
69MAP3K20.79866723
70CDK150.79783458
71PRKCE0.77648993
72PRKD30.73520861
73CAMK10.73453969
74ROCK20.73004619
75PRKCZ0.72287465
76ARAF0.71262033
77TESK10.69345583
78MAPK100.68698342
79PIK3CA0.68176606
80CDK11A0.67314264
81DYRK20.67289792
82CAMK2G0.66376816
83SGK20.66204021
84SGK10.65637617
85STK110.65497768
86PDPK10.64195323
87CSNK1G10.63490618
88DAPK10.63489588
89GRK70.61452397
90LIMK10.61277504
91TAF10.61196038
92STK380.59482711
93BMPR20.59233319
94DYRK1A0.57735336
95ERBB30.57056584
96RET0.56971621
97FYN0.56193143
98SIK20.56117945
99RPS6KB10.55300097
100MAP3K130.53539074
101ERBB40.52921774
102PDK10.51575214
103EPHA30.50063028
104MAPKAPK30.50039764
105WNK30.49824724
106RPS6KA30.49367297
107CLK10.48571173
108PRKG10.48426778
109PRKCH0.48258713
110AKT30.48217671
111IRAK20.47591197
112BMPR1B0.47320378
113ALK0.46907975
114CSNK1E0.46079349
115PRKD20.45402543
116SIK10.45299013
117RAF10.45296677
118DMPK0.43499004
119PINK10.42936829
120SIK30.40787836
121ICK0.39990978
122SGK30.39657134
123PRKCQ0.39519127
124PTK2B0.38713170
125MAPK120.38438919
126CSNK1D0.38241675
127RIPK10.38164143
128MAP4K20.37644983
129CAMK40.37640308

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.62918558
2GABAergic synapse_Homo sapiens_hsa047272.68020909
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.61807431
4Synaptic vesicle cycle_Homo sapiens_hsa047212.61384414
5Olfactory transduction_Homo sapiens_hsa047402.61146146
6Glutamatergic synapse_Homo sapiens_hsa047242.56282277
7Morphine addiction_Homo sapiens_hsa050322.51761293
8Circadian entrainment_Homo sapiens_hsa047132.43101241
9Amphetamine addiction_Homo sapiens_hsa050312.14325482
10Salivary secretion_Homo sapiens_hsa049702.04538144
11Long-term potentiation_Homo sapiens_hsa047202.01793368
12Dopaminergic synapse_Homo sapiens_hsa047282.00706560
13Serotonergic synapse_Homo sapiens_hsa047261.94501709
14Taste transduction_Homo sapiens_hsa047421.86505868
15Cholinergic synapse_Homo sapiens_hsa047251.84605952
16Insulin secretion_Homo sapiens_hsa049111.75491257
17Cocaine addiction_Homo sapiens_hsa050301.73999115
18Axon guidance_Homo sapiens_hsa043601.71689978
19Long-term depression_Homo sapiens_hsa047301.71302119
20Gastric acid secretion_Homo sapiens_hsa049711.67709626
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.66026707
22Renin secretion_Homo sapiens_hsa049241.56643355
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.55128030
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.50171637
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.47063489
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.43525680
27Collecting duct acid secretion_Homo sapiens_hsa049661.40123515
28Calcium signaling pathway_Homo sapiens_hsa040201.39535514
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.38938945
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35950086
31Oxytocin signaling pathway_Homo sapiens_hsa049211.35611933
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.34846108
33Phototransduction_Homo sapiens_hsa047441.24674453
34Gap junction_Homo sapiens_hsa045401.22545794
35cAMP signaling pathway_Homo sapiens_hsa040241.19753753
36Nitrogen metabolism_Homo sapiens_hsa009101.19294019
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18467385
38Steroid biosynthesis_Homo sapiens_hsa001001.17658933
39* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.16773719
40Vitamin B6 metabolism_Homo sapiens_hsa007501.15207048
41Dorso-ventral axis formation_Homo sapiens_hsa043201.14229380
42GnRH signaling pathway_Homo sapiens_hsa049121.10909340
43ErbB signaling pathway_Homo sapiens_hsa040121.03656743
44Ether lipid metabolism_Homo sapiens_hsa005651.01842384
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.00119826
46Fatty acid elongation_Homo sapiens_hsa000620.99029316
47Cardiac muscle contraction_Homo sapiens_hsa042600.95860536
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.94574240
49Vibrio cholerae infection_Homo sapiens_hsa051100.94211846
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93613923
51Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92727869
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88910802
53Melanogenesis_Homo sapiens_hsa049160.88310285
54Endometrial cancer_Homo sapiens_hsa052130.87249966
55Estrogen signaling pathway_Homo sapiens_hsa049150.86720460
56Pancreatic secretion_Homo sapiens_hsa049720.85386728
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85168184
58Type II diabetes mellitus_Homo sapiens_hsa049300.82783280
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.82773530
60Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82282091
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80171595
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79674466
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.78687415
64mTOR signaling pathway_Homo sapiens_hsa041500.78447117
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77572056
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76768860
67Ras signaling pathway_Homo sapiens_hsa040140.74382122
68Mineral absorption_Homo sapiens_hsa049780.74349996
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73993679
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.72791835
71Glioma_Homo sapiens_hsa052140.71636499
72AMPK signaling pathway_Homo sapiens_hsa041520.70474943
73Butanoate metabolism_Homo sapiens_hsa006500.69707168
74Choline metabolism in cancer_Homo sapiens_hsa052310.69636101
75VEGF signaling pathway_Homo sapiens_hsa043700.68587673
76Alzheimers disease_Homo sapiens_hsa050100.67600671
77Arginine and proline metabolism_Homo sapiens_hsa003300.66912959
78MAPK signaling pathway_Homo sapiens_hsa040100.66443982
79Fatty acid metabolism_Homo sapiens_hsa012120.65570723
80Ovarian steroidogenesis_Homo sapiens_hsa049130.65517875
81Dilated cardiomyopathy_Homo sapiens_hsa054140.65261647
82Thyroid hormone synthesis_Homo sapiens_hsa049180.65153407
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64832173
84Sphingolipid metabolism_Homo sapiens_hsa006000.64118053
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.63576509
86Oxidative phosphorylation_Homo sapiens_hsa001900.63537635
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63377563
88beta-Alanine metabolism_Homo sapiens_hsa004100.62039376
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61872016
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59660005
91Histidine metabolism_Homo sapiens_hsa003400.58831792
92Alcoholism_Homo sapiens_hsa050340.56772286
93Renal cell carcinoma_Homo sapiens_hsa052110.53506492
94Circadian rhythm_Homo sapiens_hsa047100.53157055
95Fatty acid biosynthesis_Homo sapiens_hsa000610.52866759
96Glucagon signaling pathway_Homo sapiens_hsa049220.50745326
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50478034
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49894897
99Insulin signaling pathway_Homo sapiens_hsa049100.49863103
100Rap1 signaling pathway_Homo sapiens_hsa040150.49642008
101Bile secretion_Homo sapiens_hsa049760.49393413
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48883480
103Wnt signaling pathway_Homo sapiens_hsa043100.48167776
1042-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47216873
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45546649
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43329980
107Prolactin signaling pathway_Homo sapiens_hsa049170.43062015
108Oocyte meiosis_Homo sapiens_hsa041140.42224495
109Inositol phosphate metabolism_Homo sapiens_hsa005620.41462771
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41458311
111Hippo signaling pathway_Homo sapiens_hsa043900.40603463
112Hedgehog signaling pathway_Homo sapiens_hsa043400.39023190
113Arginine biosynthesis_Homo sapiens_hsa002200.37885769
114* Prion diseases_Homo sapiens_hsa050200.37081462
115Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36700008
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.36268997
117Tight junction_Homo sapiens_hsa045300.35031578
118Endocytosis_Homo sapiens_hsa041440.34215915
119Parkinsons disease_Homo sapiens_hsa050120.34130691
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31309538
121Rheumatoid arthritis_Homo sapiens_hsa053230.31104576
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29168394
123Sulfur metabolism_Homo sapiens_hsa009200.29109945
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26521887
125African trypanosomiasis_Homo sapiens_hsa051430.25789738

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