NBEAL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a beige and Chediak-Higashi (BEACH) domain and multiple WD40 domains, and may play a role in megakaryocyte alpha-granule biogenesis. Mutations in this gene are a cause of gray platelet syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.69158263
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.44663255
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.44663255
4negative regulation of cell killing (GO:0031342)6.02216938
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.02216938
6regulation of gamma-delta T cell differentiation (GO:0045586)5.76819193
7antigen processing and presentation of endogenous antigen (GO:0019883)5.56315623
8positive regulation by symbiont of host defense response (GO:0052509)5.34271624
9modulation by symbiont of host defense response (GO:0052031)5.34271624
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.34271624
11positive regulation by organism of defense response of other organism involved in symbiotic interact5.34271624
12modulation by symbiont of host immune response (GO:0052553)5.34271624
13regulation of gamma-delta T cell activation (GO:0046643)5.28900129
14positive thymic T cell selection (GO:0045059)5.19511722
15detection of other organism (GO:0098543)5.06985919
16detection of bacterium (GO:0016045)4.99193184
17negative T cell selection (GO:0043383)4.85353641
18leukocyte aggregation (GO:0070486)4.83340475
19neutrophil activation involved in immune response (GO:0002283)4.70045787
20positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.69607961
21negative thymic T cell selection (GO:0045060)4.69359024
22response to peptidoglycan (GO:0032494)4.51761971
23positive T cell selection (GO:0043368)4.49925652
24response to interleukin-15 (GO:0070672)4.48139845
25thymic T cell selection (GO:0045061)4.41603633
26macrophage activation involved in immune response (GO:0002281)4.38572656
27T cell migration (GO:0072678)4.32426127
28regulation of B cell receptor signaling pathway (GO:0050855)4.31926493
29interferon-gamma production (GO:0032609)4.29537044
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.12485115
31detection of external biotic stimulus (GO:0098581)4.11667665
32antigen processing and presentation via MHC class Ib (GO:0002475)4.08627235
33T cell selection (GO:0045058)4.08230402
34negative regulation of lymphocyte mediated immunity (GO:0002707)4.01919763
35leukocyte migration involved in inflammatory response (GO:0002523)3.86189678
36positive regulation of B cell differentiation (GO:0045579)3.82291503
37negative regulation of erythrocyte differentiation (GO:0045647)3.81345423
38regulation of interferon-beta biosynthetic process (GO:0045357)3.80291477
39cellular extravasation (GO:0045123)3.80211075
40regulation of B cell differentiation (GO:0045577)3.79900068
41activated T cell proliferation (GO:0050798)3.78964911
42response to host immune response (GO:0052572)3.71048697
43response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.71048697
44leukocyte cell-cell adhesion (GO:0007159)3.67576948
45cellular response to interleukin-15 (GO:0071350)3.66679955
46respiratory burst (GO:0045730)3.65754227
47detection of molecule of bacterial origin (GO:0032490)3.61039437
48negative regulation of leukocyte mediated immunity (GO:0002704)3.60384277
49detection of biotic stimulus (GO:0009595)3.60279131
50negative regulation of T cell mediated immunity (GO:0002710)3.54575352
51positive regulation of histone deacetylation (GO:0031065)3.53527710
52response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.52815398
53response to host (GO:0075136)3.52815398
54response to host defenses (GO:0052200)3.52815398
55positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.49565068
56regulation of mast cell degranulation (GO:0043304)3.42135125
57tolerance induction (GO:0002507)3.41225283
58B cell receptor signaling pathway (GO:0050853)3.39354788
59granulocyte activation (GO:0036230)3.37183560
60regulation of interleukin-12 biosynthetic process (GO:0045075)3.32339732
61myeloid cell activation involved in immune response (GO:0002275)3.31149723
62regulation of myeloid leukocyte mediated immunity (GO:0002886)3.27500993
63T cell receptor signaling pathway (GO:0050852)3.25221781
64negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.24533249
65regulation of leukocyte degranulation (GO:0043300)3.23046503
66negative regulation of phagocytosis (GO:0050765)3.22226319
67T cell homeostasis (GO:0043029)3.20374143
68JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.20094185
69Arp2/3 complex-mediated actin nucleation (GO:0034314)3.19685903
70regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.18423896
71regulation of natural killer cell mediated immunity (GO:0002715)3.18423896
72mannose metabolic process (GO:0006013)3.14960682
73antigen receptor-mediated signaling pathway (GO:0050851)3.13655240
74positive regulation of isotype switching (GO:0045830)3.12280800
75regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.11741962
76regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.11213188
77macrophage activation (GO:0042116)3.10562963
78regulation of mast cell activation involved in immune response (GO:0033006)3.10051636
79microglial cell activation (GO:0001774)3.09496666
80negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.07053808
81positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.05693111
82production of molecular mediator involved in inflammatory response (GO:0002532)3.04274508
83positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.03569371
84negative regulation of interleukin-12 production (GO:0032695)3.03409622
85T cell costimulation (GO:0031295)3.02995552
86regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.01714918
87regulation of tolerance induction (GO:0002643)3.01686954
88regulation of type I interferon-mediated signaling pathway (GO:0060338)2.98932771
89leukocyte degranulation (GO:0043299)2.97220317
90lymphocyte costimulation (GO:0031294)2.96346291
91defense response to protozoan (GO:0042832)2.94168490
92regulation of dendritic cell antigen processing and presentation (GO:0002604)2.92392349
93mast cell activation (GO:0045576)2.91794509
94T cell proliferation (GO:0042098)2.91707976
95lymphocyte homeostasis (GO:0002260)2.91547276
96negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.90128531
97neutrophil mediated immunity (GO:0002446)2.90035263
98negative regulation of innate immune response (GO:0045824)2.88878204
99regulation of T cell tolerance induction (GO:0002664)2.86403284
100regulation of T-helper 2 cell differentiation (GO:0045628)2.85760677
101regulation of isotype switching to IgG isotypes (GO:0048302)2.83024881
102interferon-gamma-mediated signaling pathway (GO:0060333)2.82132229
103response to muramyl dipeptide (GO:0032495)2.81917968
104negative regulation of interleukin-6 production (GO:0032715)2.81845033
105positive regulation of Cdc42 GTPase activity (GO:0043089)2.81444249
106hepatocyte apoptotic process (GO:0097284)2.81178900
107definitive hemopoiesis (GO:0060216)2.80706658
108leukocyte tethering or rolling (GO:0050901)2.78293145
109regulation of regulated secretory pathway (GO:1903305)2.77792244
110lipopolysaccharide-mediated signaling pathway (GO:0031663)2.77640408
111natural killer cell activation (GO:0030101)2.77458257
112regulation of mast cell activation (GO:0033003)2.76366441
113B cell mediated immunity (GO:0019724)2.75819931
114negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.74888673
115negative regulation of T-helper cell differentiation (GO:0045623)2.74888673
116natural killer cell differentiation (GO:0001779)2.74766866
117positive regulation of protein deacetylation (GO:0090312)2.74432918
118regulation of response to interferon-gamma (GO:0060330)2.73838772
119lymphocyte migration (GO:0072676)2.73733816
120positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.73357727
121mature B cell differentiation (GO:0002335)2.72632230
122regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.71062867
123regulation of T cell receptor signaling pathway (GO:0050856)2.68256541
124positive regulation of tolerance induction (GO:0002645)2.65706210
125mast cell activation involved in immune response (GO:0002279)2.63872928
126mast cell degranulation (GO:0043303)2.63872928
127neutrophil activation (GO:0042119)2.62607001
128response to protozoan (GO:0001562)2.61991484
129myeloid dendritic cell activation (GO:0001773)2.61852294
130response to type I interferon (GO:0034340)2.60781687
131regulation of alpha-beta T cell proliferation (GO:0046640)2.60703575
132lymph node development (GO:0048535)2.60599240
133leukocyte homeostasis (GO:0001776)2.59132906
134defense response to fungus (GO:0050832)2.59021471
135negative regulation of granulocyte differentiation (GO:0030853)2.57978460
136positive regulation of B cell mediated immunity (GO:0002714)2.57358548
137positive regulation of immunoglobulin mediated immune response (GO:0002891)2.57358548
138heterotypic cell-cell adhesion (GO:0034113)2.57352938
139positive regulation of interleukin-2 production (GO:0032743)2.56993775
140adaptation of signaling pathway (GO:0023058)2.54718139
141negative regulation of glycoprotein biosynthetic process (GO:0010561)2.54664809
142B cell homeostasis (GO:0001782)2.54193017
143immunoglobulin mediated immune response (GO:0016064)2.54158109
144positive regulation of lamellipodium assembly (GO:0010592)2.52056754
145cellular defense response (GO:0006968)2.51881514
146germinal center formation (GO:0002467)2.51236743
147regulation of interleukin-2 biosynthetic process (GO:0045076)2.50694975
148Peyers patch development (GO:0048541)2.50457267
149mucosal-associated lymphoid tissue development (GO:0048537)2.50457267
150type I interferon signaling pathway (GO:0060337)2.49811736
151cellular response to type I interferon (GO:0071357)2.49811736
152response to laminar fluid shear stress (GO:0034616)2.49204108
153modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.48850211

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.31551201
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.80953158
3* MYC_22102868_ChIP-Seq_BL_Human3.62471834
4E2F7_22180533_ChIP-Seq_HELA_Human3.57519089
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.31599499
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.31490445
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.21572726
8VDR_21846776_ChIP-Seq_THP-1_Human3.11460687
9SCL_19346495_ChIP-Seq_HPC-7_Human3.03362323
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.69689323
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.65868809
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.60511162
13MAF_26560356_Chip-Seq_TH1_Human2.59084813
14FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.57247887
15* TCF7_22412390_ChIP-Seq_EML_Mouse2.52922633
16* MYB_26560356_Chip-Seq_TH2_Human2.51197022
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.51111256
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.46072505
19* RUNX_20019798_ChIP-Seq_JUKART_Human2.44668237
20UTX_26944678_Chip-Seq_JUKART_Human2.43907302
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.40975621
22IRF8_21731497_ChIP-ChIP_J774_Mouse2.39404847
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.37247790
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.34386778
25MYB_26560356_Chip-Seq_TH1_Human2.28547905
26VDR_24763502_ChIP-Seq_THP-1_Human2.23610583
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.19949587
28BRD4_27068464_Chip-Seq_AML-cells_Mouse2.19165263
29STAT4_19710469_ChIP-ChIP_TH1__Mouse2.17616828
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.16358930
31IRF8_27001747_Chip-Seq_BMDM_Mouse2.15142328
32RUNX1_22412390_ChIP-Seq_EML_Mouse2.13404651
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.10088705
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.06355657
35KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.02400597
36* SPI1_23547873_ChIP-Seq_NB4_Human2.01341472
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.98366576
38KDM2B_26808549_Chip-Seq_DND41_Human1.94831687
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.89832518
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.86845010
41SPI1_23127762_ChIP-Seq_K562_Human1.83414514
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.76325420
43ELK3_25401928_ChIP-Seq_HUVEC_Human1.70179683
44MAF_26560356_Chip-Seq_TH2_Human1.69989471
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.64488456
46FOXM1_23109430_ChIP-Seq_U2OS_Human1.61715281
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.61144785
48* GATA3_27048872_Chip-Seq_THYMUS_Human1.57571489
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.53187760
50TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.52884358
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48285859
52GATA2_22383799_ChIP-Seq_G1ME_Mouse1.39817428
53LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.39610038
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38903668
55CIITA_25753668_ChIP-Seq_RAJI_Human1.36827075
56GATA1_19941827_ChIP-Seq_MEL_Mouse1.36462636
57GATA1_22383799_ChIP-Seq_G1ME_Mouse1.36211627
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.35197540
59RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.32361664
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30172153
61* LXR_22292898_ChIP-Seq_THP-1_Human1.29978879
62EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.28417159
63TP63_17297297_ChIP-ChIP_HaCaT_Human1.27217303
64PU_27001747_Chip-Seq_BMDM_Mouse1.25555433
65VDR_24787735_ChIP-Seq_THP-1_Human1.25119820
66* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23929210
67KDM2B_26808549_Chip-Seq_JURKAT_Human1.21871277
68* NCOR1_26117541_ChIP-Seq_K562_Human1.21593451
69KDM2B_26808549_Chip-Seq_K562_Human1.19078523
70KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16111635
71GATA1_22025678_ChIP-Seq_K562_Human1.15821648
72GATA1_19941826_ChIP-Seq_K562_Human1.14715100
73* BCOR_27268052_Chip-Seq_Bcells_Human1.14713437
74GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12879764
75BCL6_27268052_Chip-Seq_Bcells_Human1.12223649
76* SA1_27219007_Chip-Seq_ERYTHROID_Human1.11663726
77PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10259055
78GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09320130
79THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08825614
80CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08608073
81P68_20966046_ChIP-Seq_HELA_Human1.08549861
82* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06450527
83LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06319906
84EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05796098
85CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03936093
86STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03360391
87* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02934768
88* GATA2_19941826_ChIP-Seq_K562_Human1.00996707
89ELF1_17652178_ChIP-ChIP_JURKAT_Human1.00207246
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99831276
91CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99525084
92NOTCH1_21737748_ChIP-Seq_TLL_Human0.97954976
93SMC4_20622854_ChIP-Seq_HELA_Human0.97535460
94* RACK7_27058665_Chip-Seq_MCF-7_Human0.97065796
95RUNX1_27514584_Chip-Seq_MCF-7_Human0.96393052
96RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.96156530
97Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.95972441
98* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95969179
99ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95623241
100GATA3_26560356_Chip-Seq_TH2_Human0.93756845
101SMAD_19615063_ChIP-ChIP_OVARY_Human0.93174392
102VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93077103
103ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90808152
104NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90163920
105PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87779946
106* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87668407
107ELF1_20517297_ChIP-Seq_JURKAT_Human0.84273536
108GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84232825
109GATA2_21666600_ChIP-Seq_HMVEC_Human0.84085662
110CTCF_27219007_Chip-Seq_ERYTHROID_Human0.83383963
111GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83233506
112CTCF_21964334_ChIP-Seq_BJAB-B_Human0.81967200
113STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.80757513
114PU.1_20513432_ChIP-Seq_Bcells_Mouse0.80635685
115SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80287069
116FOXO3_23340844_ChIP-Seq_DLD1_Human0.79097606

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology3.10791935
2MP0005671_abnormal_response_to3.02207578
3MP0000685_abnormal_immune_system3.00817146
4MP0003300_gastrointestinal_ulcer2.93064538
5MP0001835_abnormal_antigen_presentation2.85728256
6MP0002396_abnormal_hematopoietic_system2.81257851
7MP0003436_decreased_susceptibility_to2.80362943
8MP0001800_abnormal_humoral_immune2.70405364
9MP0005387_immune_system_phenotype2.54176818
10MP0001790_abnormal_immune_system2.54176818
11MP0009278_abnormal_bone_marrow2.49801535
12MP0002166_altered_tumor_susceptibility2.46391563
13MP0003303_peritoneal_inflammation2.46013810
14MP0005464_abnormal_platelet_physiology2.45487880
15MP0002420_abnormal_adaptive_immunity2.40161661
16MP0001819_abnormal_immune_cell2.37516365
17MP0002398_abnormal_bone_marrow2.36083601
18MP0005000_abnormal_immune_tolerance2.35082833
19MP0004808_abnormal_hematopoietic_stem2.34871349
20MP0005025_abnormal_response_to2.34637005
21MP0002452_abnormal_antigen_presenting2.31413805
22MP0002723_abnormal_immune_serum2.31378736
23MP0001873_stomach_inflammation2.30338744
24MP0009785_altered_susceptibility_to2.25490340
25MP0008260_abnormal_autophagy2.25183916
26MP0004947_skin_inflammation2.18182613
27MP0002419_abnormal_innate_immunity2.14649566
28MP0000716_abnormal_immune_system2.06528496
29MP0010155_abnormal_intestine_physiology2.06177596
30MP0002405_respiratory_system_inflammati2.03870926
31MP0005451_abnormal_body_composition2.00976142
32MP0003866_abnormal_defecation1.98041725
33MP0009333_abnormal_splenocyte_physiolog1.97992929
34MP0000465_gastrointestinal_hemorrhage1.97498655
35MP0002722_abnormal_immune_system1.97006313
36MP0005397_hematopoietic_system_phenotyp1.94464071
37MP0001545_abnormal_hematopoietic_system1.94464071
38MP0000689_abnormal_spleen_morphology1.91822440
39MP0000703_abnormal_thymus_morphology1.90165482
40MP0002006_tumorigenesis1.89214324
41MP0006082_CNS_inflammation1.84171403
42MP0002429_abnormal_blood_cell1.75621055
43MP0004381_abnormal_hair_follicle1.75557190
44MP0001845_abnormal_inflammatory_respons1.66915012
45MP0010352_gastrointestinal_tract_polyps1.66823198
46MP0002148_abnormal_hypersensitivity_rea1.63394629
47MP0003172_abnormal_lysosome_physiology1.58459084
48MP0005174_abnormal_tail_pigmentation1.54501770
49MP0003724_increased_susceptibility_to1.50144633
50MP0005058_abnormal_lysosome_morphology1.47926438
51MP0001853_heart_inflammation1.45985100
52MP0003566_abnormal_cell_adhesion1.43526341
53MP0000858_altered_metastatic_potential1.40135651
54MP0000490_abnormal_crypts_of1.38153945
55MP0004510_myositis1.35986469
56MP0002933_joint_inflammation1.33250706
57MP0001533_abnormal_skeleton_physiology1.29191872
58MP0003191_abnormal_cellular_cholesterol1.28966051
59MP0003448_altered_tumor_morphology1.26080905
60MP0005310_abnormal_salivary_gland1.25652799
61MP0003183_abnormal_peptide_metabolism1.21951049
62MP0005076_abnormal_cell_differentiation1.21496559
63MP0008961_abnormal_basal_metabolism1.21149735
64MP0010307_abnormal_tumor_latency1.21070012
65MP0001851_eye_inflammation1.18914055
66MP0010234_abnormal_vibrissa_follicle1.18894283
67MP0004883_abnormal_blood_vessel1.18649711
68MP0000569_abnormal_digit_pigmentation1.18191932
69MP0008469_abnormal_protein_level1.17003244
70MP0005023_abnormal_wound_healing1.09246925
71MP0002009_preneoplasia1.06015346
72MP0002019_abnormal_tumor_incidence1.00420306
73MP0009840_abnormal_foam_cell0.94038248
74MP0002877_abnormal_melanocyte_morpholog0.92646827
75MP0005075_abnormal_melanosome_morpholog0.92357355
76MP0002277_abnormal_respiratory_mucosa0.91864606
77MP0009764_decreased_sensitivity_to0.89465122
78MP0003705_abnormal_hypodermis_morpholog0.89457958
79MP0008004_abnormal_stomach_pH0.86898616
80MP0002796_impaired_skin_barrier0.85096490
81MP0003453_abnormal_keratinocyte_physiol0.83746315
82MP0003045_fibrosis0.83383418
83MP0005164_abnormal_response_to0.82973204
84MP0003690_abnormal_glial_cell0.80334682
85MP0002132_abnormal_respiratory_system0.78647508
86MP0001216_abnormal_epidermal_layer0.78570488
87MP0003828_pulmonary_edema0.78520136
88MP0005390_skeleton_phenotype0.78143798
89MP0000343_altered_response_to0.77706134
90MP0000477_abnormal_intestine_morphology0.76183150
91MP0009763_increased_sensitivity_to0.74413150
92MP0003656_abnormal_erythrocyte_physiolo0.70934261
93MP0002928_abnormal_bile_duct0.70902723
94MP0005166_decreased_susceptibility_to0.70322598
95MP0002138_abnormal_hepatobiliary_system0.70286497
96MP0001663_abnormal_digestive_system0.69294568
97MP0004185_abnormal_adipocyte_glucose0.69036327
98MP0000609_abnormal_liver_physiology0.68507461
99MP0002136_abnormal_kidney_physiology0.67327054
100MP0000015_abnormal_ear_pigmentation0.66605963
101MP0004264_abnormal_extraembryonic_tissu0.65769730
102MP0005083_abnormal_biliary_tract0.65700499
103MP0002998_abnormal_bone_remodeling0.65374626
104MP0003795_abnormal_bone_structure0.64489665
105MP0000371_diluted_coat_color0.64093863
106MP0005409_darkened_coat_color0.63347233
107MP0006054_spinal_hemorrhage0.63094761
108MP0009931_abnormal_skin_appearance0.62452362
109MP0001849_ear_inflammation0.62412486
110MP0002095_abnormal_skin_pigmentation0.61683381
111MP0003693_abnormal_embryo_hatching0.60108755
112MP0001191_abnormal_skin_condition0.60005688
113MP0000249_abnormal_blood_vessel0.59957596
114MP0003075_altered_response_to0.58804516
115MP0003091_abnormal_cell_migration0.58798519
116MP0001986_abnormal_taste_sensitivity0.57648680
117MP0005666_abnormal_adipose_tissue0.57568104
118MP0008874_decreased_physiological_sensi0.56787558
119MP0003221_abnormal_cardiomyocyte_apopto0.55314230
120MP0000598_abnormal_liver_morphology0.54998738
121MP0003943_abnormal_hepatobiliary_system0.54842459

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.60562066
2T lymphocytopenia (HP:0005403)4.29786757
3Recurrent abscess formation (HP:0002722)4.29742409
4Recurrent fungal infections (HP:0002841)4.26238551
5Abnormal delayed hypersensitivity skin test (HP:0002963)4.12708389
6Recurrent viral infections (HP:0004429)4.12087907
7Nasal polyposis (HP:0100582)4.09123888
8Abnormality of T cell number (HP:0011839)4.03120989
9Pustule (HP:0200039)4.01236005
10IgM deficiency (HP:0002850)3.90085072
11Gastrointestinal infarctions (HP:0005244)3.83839778
12Chronic otitis media (HP:0000389)3.83565285
13Abnormality of the nasal mucosa (HP:0000433)3.78531692
14Recurrent bacterial skin infections (HP:0005406)3.75648041
15Myositis (HP:0100614)3.71881134
16Abnormality of the fingertips (HP:0001211)3.68902756
17Panhypogammaglobulinemia (HP:0003139)3.65182987
18Abnormality of T cells (HP:0002843)3.50452154
19Inflammation of the large intestine (HP:0002037)3.47219517
20Gastrointestinal inflammation (HP:0004386)3.42898631
21Elevated erythrocyte sedimentation rate (HP:0003565)3.38767595
22Spontaneous hematomas (HP:0007420)3.31509479
23Increased IgE level (HP:0003212)3.21383609
24Keratoconjunctivitis sicca (HP:0001097)3.18370108
25Recurrent cutaneous fungal infections (HP:0011370)3.16869011
26Chronic mucocutaneous candidiasis (HP:0002728)3.16869011
27Urticaria (HP:0001025)3.10023040
28Meningitis (HP:0001287)3.04745804
29Recurrent bronchitis (HP:0002837)3.04681473
30Colitis (HP:0002583)3.02002798
31Recurrent skin infections (HP:0001581)2.97899873
32Autoimmune thrombocytopenia (HP:0001973)2.91848167
33Hypochromic anemia (HP:0001931)2.90310125
34Recurrent gram-negative bacterial infections (HP:0005420)2.88392174
35Thrombocytosis (HP:0001894)2.87823558
36Keratoconjunctivitis (HP:0001096)2.87285075
37Cellulitis (HP:0100658)2.83797574
38Abnormality of T cell physiology (HP:0011840)2.82525825
39Abnormality of macrophages (HP:0004311)2.74105725
40Periodontitis (HP:0000704)2.74088534
41* Prolonged bleeding time (HP:0003010)2.73678958
42Abnormal platelet volume (HP:0011876)2.70017207
43Hypochromic microcytic anemia (HP:0004840)2.69230527
44Petechiae (HP:0000967)2.63717841
45Abnormality of B cell number (HP:0010975)2.59138502
46B lymphocytopenia (HP:0010976)2.59138502
47Mediastinal lymphadenopathy (HP:0100721)2.58726903
48Verrucae (HP:0200043)2.57372055
49Papilloma (HP:0012740)2.57372055
50Gingival bleeding (HP:0000225)2.54885625
51Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.54617977
52Interstitial pulmonary disease (HP:0006530)2.54145207
53Obstructive lung disease (HP:0006536)2.53060460
54Chronic obstructive pulmonary disease (HP:0006510)2.53060460
55Pulmonary infiltrates (HP:0002113)2.52265408
56Arterial thrombosis (HP:0004420)2.47306800
57* Epistaxis (HP:0000421)2.44860732
58Leukocytosis (HP:0001974)2.44738702
59Eosinophilia (HP:0001880)2.44671978
60Thyroiditis (HP:0100646)2.44150632
61Gingivitis (HP:0000230)2.41587112
62Hematochezia (HP:0002573)2.40900826
63Orchitis (HP:0100796)2.39819133
64Vasculitis (HP:0002633)2.39150879
65Episodic fever (HP:0001954)2.38984456
66Chest pain (HP:0100749)2.37761859
67Vacuolated lymphocytes (HP:0001922)2.36292328
68Stomatitis (HP:0010280)2.36216498
69Granulocytopenia (HP:0001913)2.30741882
70Lymphopenia (HP:0001888)2.29861705
71Sepsis (HP:0100806)2.27751907
72Increased IgM level (HP:0003496)2.25619735
73Viral hepatitis (HP:0006562)2.24589688
74Anorexia (HP:0002039)2.24521825
75Increased density of long bones (HP:0006392)2.24334664
76Increased mean platelet volume (HP:0011877)2.24203654
77Encephalitis (HP:0002383)2.23704644
78Abnormality of cells of the lymphoid lineage (HP:0012140)2.23324851
79Ureteral stenosis (HP:0000071)2.21458849
80Severe combined immunodeficiency (HP:0004430)2.21022743
81Dysostosis multiplex (HP:0000943)2.20852377
82Hypergammaglobulinemia (HP:0010702)2.20374465
83Metaphyseal cupping (HP:0003021)2.19062006
84Hemoptysis (HP:0002105)2.17078305
85Cerebral aneurysm (HP:0004944)2.16648944
86Slow saccadic eye movements (HP:0000514)2.16226718
87Gastrointestinal stroma tumor (HP:0100723)2.15402243
88Abnormality of eosinophils (HP:0001879)2.13946827
89Peritonitis (HP:0002586)2.13667463
90Retrobulbar optic neuritis (HP:0100654)2.12295560
91Optic neuritis (HP:0100653)2.12295560
92Combined immunodeficiency (HP:0005387)2.11301082
93Premature loss of primary teeth (HP:0006323)2.11236571
94Thoracic kyphosis (HP:0002942)2.10049983
95Amyloidosis (HP:0011034)2.06983645
96Skin ulcer (HP:0200042)2.06890896
97Chronic diarrhea (HP:0002028)2.05964311
98Hyperacusis (HP:0010780)2.05818591
99Agammaglobulinemia (HP:0004432)2.05575977
100Ureteral obstruction (HP:0006000)2.04375221
101Increased serum ferritin (HP:0003281)1.99761345
102Malnutrition (HP:0004395)1.99728760
103Abnormality of the thoracic spine (HP:0100711)1.99221470
104Abnormality of the peritoneum (HP:0002585)1.98618146
105Fatigue (HP:0012378)1.97988107
106Microcytic anemia (HP:0001935)1.97126251
107Gangrene (HP:0100758)1.96551065
108Autoimmune hemolytic anemia (HP:0001890)1.96483823
109Abnormality of the pleura (HP:0002103)1.96472538
110Joint swelling (HP:0001386)1.96003307
111Broad face (HP:0000283)1.95007882
112Urinary glycosaminoglycan excretion (HP:0003541)1.94482784
113Mucopolysacchariduria (HP:0008155)1.94482784
114Cheilitis (HP:0100825)1.94098217
115IgG deficiency (HP:0004315)1.93504348
116Subacute progressive viral hepatitis (HP:0006572)1.92413449
117Systemic lupus erythematosus (HP:0002725)1.91816891
118Polygenic inheritance (HP:0010982)1.91091890
119IgA deficiency (HP:0002720)1.90953453
120Increased cerebral lipofuscin (HP:0011813)1.88532454
121Basal cell carcinoma (HP:0002671)1.88377507
122Pulmonary embolism (HP:0002204)1.86309758
123Spondylolisthesis (HP:0003302)1.86162874
124Restrictive lung disease (HP:0002091)1.85666062
125Segmental peripheral demyelination/remyelination (HP:0003481)1.85136388
126Abnormality of polysaccharide metabolism (HP:0011012)1.84429977
127Abnormality of glycosaminoglycan metabolism (HP:0004371)1.84429977
128Abnormality of mucopolysaccharide metabolism (HP:0011020)1.84429977
129Abnormality of the endocardium (HP:0004306)1.83349946
130Purpura (HP:0000979)1.82860705
131* Impaired platelet aggregation (HP:0003540)1.82788536
132* Abnormal platelet function (HP:0011869)1.82788536
133Acute myeloid leukemia (HP:0004808)1.82782580
134Bicuspid aortic valve (HP:0001647)1.81043331
135Osteomyelitis (HP:0002754)1.80429981
136Obstructive sleep apnea (HP:0002870)1.80192904
137Abnormality of iron homeostasis (HP:0011031)1.79841030
138Hepatosplenomegaly (HP:0001433)1.79533525

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.82337357
2EEF2K3.25535965
3PRPF4B3.22211884
4PKN22.75789105
5TRIB32.71031785
6TXK2.58139404
7JAK32.47732019
8STK102.41997129
9ZAP702.35329314
10TYK22.18284756
11MAP3K102.17647863
12ITK2.15317438
13GRK62.07847221
14BTK1.92523601
15EPHB11.91412366
16TAOK31.86238756
17ERN11.81498651
18SMG11.75597830
19FGFR41.70136839
20TTN1.59462024
21TGFBR21.58657493
22LRRK21.58048499
23CDK121.56595747
24SIK21.55915671
25JAK11.54882141
26KIT1.51846860
27PTK61.50175100
28CSK1.49353480
29HCK1.45908040
30FES1.43986573
31IRAK41.43359713
32SIK31.42718620
33BLK1.42153696
34TEC1.40448550
35MAP2K31.38665377
36LCK1.38133574
37SYK1.34404867
38MAP3K131.33937480
39FGR1.32395137
40IKBKE1.31337958
41FGFR31.28754017
42TBK11.28393902
43CSF1R1.22470510
44FLT31.21821585
45MAP3K141.18793352
46MAP3K71.18128417
47CAMK1D1.16951874
48KSR21.16939897
49MAP3K61.13022795
50RIPK11.08435771
51CAMK1G1.05542980
52PIM10.99600892
53CDC42BPA0.99434208
54RPS6KA40.98947368
55PRKCH0.98730517
56MARK30.97170163
57JAK20.95182955
58TRPM70.94880036
59YES10.92998425
60CDK40.88732475
61NEK20.85854214
62CLK10.84185061
63RPS6KB20.81593206
64RIPK40.81090411
65PDPK10.80485375
66TAOK20.77841607
67TAOK10.77778221
68HIPK20.77609918
69TNK20.77263496
70IRAK10.77138263
71SIK10.76214999
72PAK40.74383838
73IRAK20.73543157
74MAPK120.73045783
75ALK0.72455023
76ICK0.72127892
77BRD40.72050876
78MATK0.70599577
79CDK60.70044122
80KDR0.69396326
81IKBKB0.68042666
82IRAK30.66436177
83MAPK70.65618423
84NLK0.63993265
85LYN0.61481609
86MAP3K20.60299436
87SCYL20.58625691
88CHUK0.58531922
89MAPKAPK30.58515711
90MST40.58200941
91PRKCQ0.56854300
92NME20.56369554
93FYN0.56187992
94PDGFRB0.55703558
95TGFBR10.55623424
96BMPR20.54854675
97STK40.54539627
98DMPK0.51970407
99TESK20.51379062
100MAP2K60.51068286
101PDK10.50123790
102EPHA30.48799403
103CDK90.48771335
104MAP3K80.48497766
105MTOR0.46641984
106RPS6KA60.46514062
107PASK0.45785859
108MARK20.45726338
109PRKD20.45141737
110PTK2B0.43314201
111MST1R0.43203318
112BMX0.42949900
113RPS6KL10.41730768
114RPS6KC10.41730768
115MAP3K110.40987195
116PTK20.40339226
117MAPKAPK20.40097874
118STK110.40050375
119CAMKK10.40027022
120SGK30.39683161
121MAP3K30.39229810
122MAP3K10.39049884
123MAP2K20.38622650
124MAPK110.38478471
125RPS6KA20.38144540
126DYRK1B0.36797567
127RET0.35150748
128STK380.34557316
129MAP2K40.32272309

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.48930116
2Leishmaniasis_Homo sapiens_hsa051402.50305478
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.47708648
4T cell receptor signaling pathway_Homo sapiens_hsa046602.37652562
5B cell receptor signaling pathway_Homo sapiens_hsa046622.35998019
6Antigen processing and presentation_Homo sapiens_hsa046122.27453484
7Osteoclast differentiation_Homo sapiens_hsa043802.21595828
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.18673971
9Staphylococcus aureus infection_Homo sapiens_hsa051502.06241854
10Hematopoietic cell lineage_Homo sapiens_hsa046402.05751275
11Measles_Homo sapiens_hsa051622.03873509
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.92210746
13Leukocyte transendothelial migration_Homo sapiens_hsa046701.88996567
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.85726118
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.84359593
16Acute myeloid leukemia_Homo sapiens_hsa052211.82980865
17Autoimmune thyroid disease_Homo sapiens_hsa053201.79968641
18Jak-STAT signaling pathway_Homo sapiens_hsa046301.67873074
19Other glycan degradation_Homo sapiens_hsa005111.66461582
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.63062023
21Chronic myeloid leukemia_Homo sapiens_hsa052201.62849256
22Toxoplasmosis_Homo sapiens_hsa051451.60852527
23Platelet activation_Homo sapiens_hsa046111.51787583
24Graft-versus-host disease_Homo sapiens_hsa053321.50051674
25Chemokine signaling pathway_Homo sapiens_hsa040621.46065886
26Viral myocarditis_Homo sapiens_hsa054161.40560285
27Herpes simplex infection_Homo sapiens_hsa051681.33988423
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.31544804
29Pancreatic cancer_Homo sapiens_hsa052121.31160779
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.31097876
31Hepatitis B_Homo sapiens_hsa051611.30232462
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.29500640
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.26879915
34Influenza A_Homo sapiens_hsa051641.23268993
35Shigellosis_Homo sapiens_hsa051311.23239152
36Apoptosis_Homo sapiens_hsa042101.22491886
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.21903105
38Pertussis_Homo sapiens_hsa051331.21700292
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.20600547
40Caffeine metabolism_Homo sapiens_hsa002321.18161735
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.16617143
42Non-small cell lung cancer_Homo sapiens_hsa052231.16563116
43TNF signaling pathway_Homo sapiens_hsa046681.12642079
44Tuberculosis_Homo sapiens_hsa051521.10624240
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08039861
46VEGF signaling pathway_Homo sapiens_hsa043701.07884207
47Transcriptional misregulation in cancer_Homo sapiens_hsa052021.06598242
48African trypanosomiasis_Homo sapiens_hsa051431.02820296
49Neurotrophin signaling pathway_Homo sapiens_hsa047221.01668198
50Allograft rejection_Homo sapiens_hsa053301.00995574
51Legionellosis_Homo sapiens_hsa051341.00530422
52Small cell lung cancer_Homo sapiens_hsa052220.99612299
53Lysine degradation_Homo sapiens_hsa003100.98792666
54Malaria_Homo sapiens_hsa051440.97880557
55HTLV-I infection_Homo sapiens_hsa051660.96641479
56Choline metabolism in cancer_Homo sapiens_hsa052310.95443578
57Phagosome_Homo sapiens_hsa041450.92283954
58Hepatitis C_Homo sapiens_hsa051600.91619817
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90639951
60Insulin resistance_Homo sapiens_hsa049310.90088453
61Prolactin signaling pathway_Homo sapiens_hsa049170.88892055
62GnRH signaling pathway_Homo sapiens_hsa049120.87323271
63Colorectal cancer_Homo sapiens_hsa052100.86005203
64Notch signaling pathway_Homo sapiens_hsa043300.82839290
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80941555
66mTOR signaling pathway_Homo sapiens_hsa041500.75850095
67ABC transporters_Homo sapiens_hsa020100.75688411
68Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75440096
69Salmonella infection_Homo sapiens_hsa051320.75343588
70Viral carcinogenesis_Homo sapiens_hsa052030.74689620
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74414575
72Lysosome_Homo sapiens_hsa041420.70663054
73Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69374828
74ErbB signaling pathway_Homo sapiens_hsa040120.69223702
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69206260
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66588555
77Epstein-Barr virus infection_Homo sapiens_hsa051690.66222359
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65805271
79Endometrial cancer_Homo sapiens_hsa052130.62100238
80Proteoglycans in cancer_Homo sapiens_hsa052050.61325420
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61269751
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.60522595
83Estrogen signaling pathway_Homo sapiens_hsa049150.60031526
84Asthma_Homo sapiens_hsa053100.59040728
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58854901
86Inositol phosphate metabolism_Homo sapiens_hsa005620.58716957
87FoxO signaling pathway_Homo sapiens_hsa040680.58020616
88Glioma_Homo sapiens_hsa052140.57966138
89Endocytosis_Homo sapiens_hsa041440.56782292
90Renal cell carcinoma_Homo sapiens_hsa052110.54844627
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54794116
92Focal adhesion_Homo sapiens_hsa045100.54218663
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.53537731
94HIF-1 signaling pathway_Homo sapiens_hsa040660.53421117
95Thyroid cancer_Homo sapiens_hsa052160.52508604
96MAPK signaling pathway_Homo sapiens_hsa040100.52451562
97Bladder cancer_Homo sapiens_hsa052190.51721528
98Rheumatoid arthritis_Homo sapiens_hsa053230.51155692
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50456596
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50011859
101Rap1 signaling pathway_Homo sapiens_hsa040150.49727855
102Type II diabetes mellitus_Homo sapiens_hsa049300.49469617
103Amoebiasis_Homo sapiens_hsa051460.47940423
104MicroRNAs in cancer_Homo sapiens_hsa052060.47534807
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45335029
106Prostate cancer_Homo sapiens_hsa052150.45251291
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.42775629
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.42546248
109Insulin signaling pathway_Homo sapiens_hsa049100.40412509
110Pathways in cancer_Homo sapiens_hsa052000.40258959
111Type I diabetes mellitus_Homo sapiens_hsa049400.39025586
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.38872136
113Adherens junction_Homo sapiens_hsa045200.38789328
114Dorso-ventral axis formation_Homo sapiens_hsa043200.38541933
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35828144

Most similar genes based on co-expression Upload to Enrichr

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