NAV2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the neuron navigator gene family, which may play a role in cellular growth and migration. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)4.16048671
2histone H3-K4 trimethylation (GO:0080182)4.02418805
3lateral sprouting from an epithelium (GO:0060601)3.79830027
4regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.72643764
5notochord development (GO:0030903)3.42230660
6chondrocyte proliferation (GO:0035988)3.30975932
7neuronal ion channel clustering (GO:0045161)3.21388646
8planar cell polarity pathway involved in neural tube closure (GO:0090179)3.13983409
9axon extension involved in axon guidance (GO:0048846)3.10062404
10neuron projection extension involved in neuron projection guidance (GO:1902284)3.10062404
11peripheral nervous system axon ensheathment (GO:0032292)3.03107871
12myelination in peripheral nervous system (GO:0022011)3.03107871
13regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.96756756
14negative regulation of osteoblast proliferation (GO:0033689)2.94810657
15regulation of non-canonical Wnt signaling pathway (GO:2000050)2.93640962
16regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.90632559
17prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.88809761
18negative regulation of chondrocyte differentiation (GO:0032331)2.82736179
19presynaptic membrane assembly (GO:0097105)2.82262355
20hippo signaling (GO:0035329)2.81897022
21cell migration involved in sprouting angiogenesis (GO:0002042)2.79454657
22embryonic foregut morphogenesis (GO:0048617)2.78629968
23melanin biosynthetic process (GO:0042438)2.77819813
24adult heart development (GO:0007512)2.77614086
25regulation of pigment cell differentiation (GO:0050932)2.76597206
26dendrite morphogenesis (GO:0048813)2.75802934
27limb bud formation (GO:0060174)2.70458921
28branching involved in salivary gland morphogenesis (GO:0060445)2.68139139
29somite development (GO:0061053)2.65778422
30L-amino acid import (GO:0043092)2.64676435
31mesenchymal-epithelial cell signaling (GO:0060638)2.64310976
32regulation of axon guidance (GO:1902667)2.63627639
33detection of calcium ion (GO:0005513)2.62581597
34apical protein localization (GO:0045176)2.61480528
35locomotory exploration behavior (GO:0035641)2.58265327
36endothelial cell morphogenesis (GO:0001886)2.57219388
37glomerular visceral epithelial cell development (GO:0072015)2.57118191
38type B pancreatic cell development (GO:0003323)2.55464654
39lymphangiogenesis (GO:0001946)2.53931784
40negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.53860649
41negative regulation of translation, ncRNA-mediated (GO:0040033)2.53860649
42regulation of translation, ncRNA-mediated (GO:0045974)2.53860649
43histone H3-K4 methylation (GO:0051568)2.51309193
44Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.50942457
45spinal cord motor neuron differentiation (GO:0021522)2.50152601
46neuron cell-cell adhesion (GO:0007158)2.49612623
47mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.47459980
48mesenchymal cell differentiation (GO:0048762)2.47384347
49regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.45852177
50glomerular epithelial cell development (GO:0072310)2.45127175
51retina vasculature morphogenesis in camera-type eye (GO:0061299)2.44741797
52regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.44262163
53regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.44169887
54retrograde transport, vesicle recycling within Golgi (GO:0000301)2.42637045
55desmosome organization (GO:0002934)2.42480143
56central nervous system projection neuron axonogenesis (GO:0021952)2.41982188
57cytoskeletal anchoring at plasma membrane (GO:0007016)2.41867183
58pharyngeal system development (GO:0060037)2.41519644
59anterior/posterior axis specification, embryo (GO:0008595)2.41342116
60artery development (GO:0060840)2.41218151
61membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.40538911
62craniofacial suture morphogenesis (GO:0097094)2.39505767
63regulation of establishment of planar polarity (GO:0090175)2.39469807
64hemidesmosome assembly (GO:0031581)2.39437828
65regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.37911608
66cell differentiation involved in kidney development (GO:0061005)2.37322085
67cerebellar Purkinje cell differentiation (GO:0021702)2.36357790
68regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.36150783
69presynaptic membrane organization (GO:0097090)2.35925998
70regulation of cardioblast differentiation (GO:0051890)2.35761954
71cerebral cortex radially oriented cell migration (GO:0021799)2.34354176
72developmental pigmentation (GO:0048066)2.34142002
73ganglion development (GO:0061548)2.33821006
74secondary metabolite biosynthetic process (GO:0044550)2.33759584
75atrial septum morphogenesis (GO:0060413)2.33380192
76peptidyl-lysine trimethylation (GO:0018023)2.33244434
77regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.32747708
78cell adhesion mediated by integrin (GO:0033627)2.32487130
79melanin metabolic process (GO:0006582)2.31912094
80skin morphogenesis (GO:0043589)2.31709099
81ionotropic glutamate receptor signaling pathway (GO:0035235)2.31133204
82cellular response to cholesterol (GO:0071397)2.30719882
83regulation of gene silencing by RNA (GO:0060966)2.30501222
84regulation of posttranscriptional gene silencing (GO:0060147)2.30501222
85regulation of gene silencing by miRNA (GO:0060964)2.30501222
86heart morphogenesis (GO:0003007)2.30363313
87prostate gland growth (GO:0060736)2.28640622
88G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.28591742
89myotube differentiation (GO:0014902)2.28583961
90negative chemotaxis (GO:0050919)2.27575635
91non-canonical Wnt signaling pathway (GO:0035567)2.27533326
92collagen fibril organization (GO:0030199)2.27327900
93protein targeting to Golgi (GO:0000042)2.27267754
94positive regulation of action potential (GO:0045760)2.27144857
95cell communication by electrical coupling (GO:0010644)2.26765474
96negative regulation of keratinocyte proliferation (GO:0010839)2.26689565
97negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.25904351
98cell migration involved in heart development (GO:0060973)2.25820853
99epithelial cell-cell adhesion (GO:0090136)2.25656577
100transmission of nerve impulse (GO:0019226)2.24563252
101positive regulation of smoothened signaling pathway (GO:0045880)2.23985219
102endodermal cell differentiation (GO:0035987)2.23316649
103regulation of transforming growth factor beta2 production (GO:0032909)2.23149053
104insulin-like growth factor receptor signaling pathway (GO:0048009)2.23031527
105glutamate receptor signaling pathway (GO:0007215)2.22523256
106lung-associated mesenchyme development (GO:0060484)2.22414697
107negative regulation of axon extension involved in axon guidance (GO:0048843)2.21688785
108response to redox state (GO:0051775)2.21499412
109basement membrane organization (GO:0071711)2.21446718
110establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.21120770
111dorsal/ventral axis specification (GO:0009950)2.20509799
112lung epithelium development (GO:0060428)2.20305125
113embryonic retina morphogenesis in camera-type eye (GO:0060059)2.20293742
114neural tube development (GO:0021915)2.20030619
115cardiac myofibril assembly (GO:0055003)2.19823001
116organ growth (GO:0035265)2.19803599
117establishment of protein localization to Golgi (GO:0072600)2.19662224
118gap junction assembly (GO:0016264)2.19556073
119bone trabecula formation (GO:0060346)2.19173690
120regulation of glutamate receptor signaling pathway (GO:1900449)2.19030914
121regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.17599597
122synaptic vesicle docking involved in exocytosis (GO:0016081)2.15563530
123regulation of hippo signaling (GO:0035330)2.15015908
124dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.14044228
125cell proliferation in forebrain (GO:0021846)2.12080424
126regulation of catenin import into nucleus (GO:0035412)2.11903782
127female gonad development (GO:0008585)2.11479777
128dendritic spine morphogenesis (GO:0060997)2.11417607
129positive regulation of meiosis (GO:0045836)2.11036146
130postsynaptic membrane organization (GO:0001941)2.10586912
131response to pheromone (GO:0019236)2.10173921
132positive regulation of catenin import into nucleus (GO:0035413)2.10167878
133myelination (GO:0042552)2.10106632
134asymmetric protein localization (GO:0008105)2.10071489
135establishment of apical/basal cell polarity (GO:0035089)2.09951328
136macroautophagy (GO:0016236)2.09788013
137negative regulation of hormone biosynthetic process (GO:0032353)2.09255912
138positive regulation of SMAD protein import into nucleus (GO:0060391)2.09238606
139convergent extension (GO:0060026)2.08669548
140negative regulation of smoothened signaling pathway (GO:0045879)2.07989349
141negative regulation of catenin import into nucleus (GO:0035414)2.07935715
142calcium ion import (GO:0070509)2.07798489
143substrate adhesion-dependent cell spreading (GO:0034446)2.07546130
144chondroitin sulfate catabolic process (GO:0030207)2.07419815
145membrane assembly (GO:0071709)2.07279662
146membrane depolarization during action potential (GO:0086010)2.06660495
147axon extension (GO:0048675)2.06510671
148amino acid import (GO:0043090)2.06448775
149cochlea morphogenesis (GO:0090103)2.06082199
150axonal fasciculation (GO:0007413)2.05566535
151negative regulation of Rho protein signal transduction (GO:0035024)2.05505341
152cardiac muscle hypertrophy (GO:0003300)2.05328644
153cytoplasmic mRNA processing body assembly (GO:0033962)2.05152033
154cell-substrate junction assembly (GO:0007044)2.04780916
155synaptic vesicle endocytosis (GO:0048488)2.04704482
156establishment or maintenance of bipolar cell polarity (GO:0061245)2.04507278
157establishment or maintenance of apical/basal cell polarity (GO:0035088)2.04507278
158regulation of smoothened signaling pathway (GO:0008589)2.04367863
159axon ensheathment (GO:0008366)2.04258647
160ensheathment of neurons (GO:0007272)2.04258647
161negative regulation of axon guidance (GO:1902668)2.03955853
162G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.03669446
163regulation of axon extension involved in axon guidance (GO:0048841)2.03653792
164adherens junction assembly (GO:0034333)2.03507980
165vocalization behavior (GO:0071625)2.03469187
166negative regulation of neurotransmitter secretion (GO:0046929)2.03107863
167body morphogenesis (GO:0010171)2.03076206
168myofibril assembly (GO:0030239)2.02274616
169eye photoreceptor cell differentiation (GO:0001754)2.01963165
170photoreceptor cell differentiation (GO:0046530)2.01963165
171positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.01773754
172neuron recognition (GO:0008038)2.01387108
173peptidyl-tyrosine autophosphorylation (GO:0038083)2.01292872
174glandular epithelial cell development (GO:0002068)2.00584784
175semaphorin-plexin signaling pathway (GO:0071526)1.99557708
176regulation of neuron migration (GO:2001222)1.99377193
177forebrain neuron development (GO:0021884)1.99376830
178pigmentation (GO:0043473)1.99247950
179positive regulation of bone mineralization (GO:0030501)1.98550458
180regulation of developmental pigmentation (GO:0048070)1.97461738
181regulation of keratinocyte proliferation (GO:0010837)1.97229857

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.61773242
2EZH2_22144423_ChIP-Seq_EOC_Human3.37488919
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.64562874
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.50710519
5DROSHA_22980978_ChIP-Seq_HELA_Human2.06929059
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.03135272
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.02825729
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.98979566
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.97603103
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.97384661
11* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.90830074
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.88771670
13* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.88641599
14VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.86436800
15PIAS1_25552417_ChIP-Seq_VCAP_Human1.85048375
16EED_16625203_ChIP-ChIP_MESCs_Mouse1.83916504
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83838925
18* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.83324946
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.81403287
20EZH2_27304074_Chip-Seq_ESCs_Mouse1.80204787
21EZH2_18974828_ChIP-Seq_MESCs_Mouse1.78753773
22RNF2_18974828_ChIP-Seq_MESCs_Mouse1.78753773
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.75564326
24AR_21572438_ChIP-Seq_LNCaP_Human1.72631161
25SMAD4_21799915_ChIP-Seq_A2780_Human1.72563970
26* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.71386057
27EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.71193056
28WT1_19549856_ChIP-ChIP_CCG9911_Human1.67392658
29* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.66514381
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65827919
31WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.65454496
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.65006061
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.63016572
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.61718628
35ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.60774320
36* STAT3_23295773_ChIP-Seq_U87_Human1.60057265
37* RNF2_27304074_Chip-Seq_ESCs_Mouse1.60004822
38JARID2_20075857_ChIP-Seq_MESCs_Mouse1.59305858
39AHR_22903824_ChIP-Seq_MCF-7_Human1.58489288
40NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.57539457
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.56679891
42ARNT_22903824_ChIP-Seq_MCF-7_Human1.53142203
43TP53_16413492_ChIP-PET_HCT116_Human1.52321367
44* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.52162967
45* P300_19829295_ChIP-Seq_ESCs_Human1.50949705
46NFIB_24661679_ChIP-Seq_LUNG_Mouse1.49636105
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47860496
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.47344458
49RARG_19884340_ChIP-ChIP_MEFs_Mouse1.46464618
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46337416
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.44761759
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42992517
53* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.42946106
54CJUN_26792858_Chip-Seq_BT549_Human1.42871823
55* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42710641
56* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42710641
57EP300_21415370_ChIP-Seq_HL-1_Mouse1.42120248
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41352787
59SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.41013928
60EZH2_27294783_Chip-Seq_ESCs_Mouse1.39124605
61SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.38534715
62STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.38209117
63* TCF4_23295773_ChIP-Seq_U87_Human1.37376147
64CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.36971970
65* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.36201826
66* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.33740903
67TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.33670404
68RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32861934
69SUZ12_27294783_Chip-Seq_ESCs_Mouse1.32761684
70SALL1_21062744_ChIP-ChIP_HESCs_Human1.32282067
71* SOX2_21211035_ChIP-Seq_LN229_Gbm1.32249493
72* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31099476
73FUS_26573619_Chip-Seq_HEK293_Human1.31085829
74TAF15_26573619_Chip-Seq_HEK293_Human1.30505258
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30478280
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28597544
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28009675
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.27510934
79IGF1R_20145208_ChIP-Seq_DFB_Human1.26201837
80* BRD4_25478319_ChIP-Seq_HGPS_Human1.26171988
81* REST_21632747_ChIP-Seq_MESCs_Mouse1.24564899
82PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24178137
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21245111
84ISL1_27105846_Chip-Seq_CPCs_Mouse1.21099908
85TP63_17297297_ChIP-ChIP_HaCaT_Human1.21097798
86RUNX2_22187159_ChIP-Seq_PCA_Human1.20753530
87* AR_19668381_ChIP-Seq_PC3_Human1.20452955
88NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20417162
89* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.20097814
90* FOXA2_19822575_ChIP-Seq_HepG2_Human1.19230645
91RING1B_27294783_Chip-Seq_NPCs_Mouse1.18925655
92* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.18908882
93* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.17733545
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15287242
95POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.14915179
96HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14664781
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14567662
98* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.14068625
99EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12454444
100* ESR2_21235772_ChIP-Seq_MCF-7_Human1.12448853
101RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12245807
102E2F1_18555785_Chip-Seq_ESCs_Mouse1.12135466
103DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.11517622
104RXR_22108803_ChIP-Seq_LS180_Human1.11501538
105CLOCK_20551151_ChIP-Seq_293T_Human1.11138631
106AR_25329375_ChIP-Seq_VCAP_Human1.10990346
107ER_23166858_ChIP-Seq_MCF-7_Human1.10848752
108TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09771407
109SMAD3_21741376_ChIP-Seq_HESCs_Human1.09509119
110LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09018216
111RING1B_27294783_Chip-Seq_ESCs_Mouse1.07890228
112CBX2_27304074_Chip-Seq_ESCs_Mouse1.07814362
113SOX9_26525672_Chip-Seq_HEART_Mouse1.07288766
114TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07186019
115* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.06053351
116NR3C1_23031785_ChIP-Seq_PC12_Mouse1.06014312
117AR_21909140_ChIP-Seq_LNCAP_Human1.05584935
118BCAT_22108803_ChIP-Seq_LS180_Human1.05340505
119ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05207045
120ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.05145680
121NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05111426
122NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05111426
123SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03976299
124* SMAD4_21741376_ChIP-Seq_HESCs_Human1.02653385
125TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.02599119
126BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02500810
127TCF4_18268006_ChIP-ChIP_LS174T_Human1.02135988
128TP53_18474530_ChIP-ChIP_U2OS_Human1.01229134
129BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01000432
130NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.00958727
131ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00884849
132PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00177365
133P53_22387025_ChIP-Seq_ESCs_Mouse0.99695306
134TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99690732
135TCF3_18692474_ChIP-Seq_MESCs_Mouse0.99678710
136TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99482017
137CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99340584
138CMYC_18555785_Chip-Seq_ESCs_Mouse0.99030486
139ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98313482
140TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98215056
141NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97743898
142UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97610017

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.31688129
2MP0000566_synostosis3.26062624
3MP0008438_abnormal_cutaneous_collagen3.03201109
4MP0003941_abnormal_skin_development2.72738550
5MP0005257_abnormal_intraocular_pressure2.63099232
6MP0001299_abnormal_eye_distance/2.38636379
7MP0009780_abnormal_chondrocyte_physiolo2.37976789
8MP0010030_abnormal_orbit_morphology2.33403876
9MP0004859_abnormal_synaptic_plasticity2.31540190
10MP0003705_abnormal_hypodermis_morpholog2.29080489
11MP0010368_abnormal_lymphatic_system2.27816928
12MP0003950_abnormal_plasma_membrane2.15920698
13MP0002938_white_spotting2.15159200
14MP0003787_abnormal_imprinting2.09018003
15MP0000462_abnormal_digestive_system2.06415134
16MP0004270_analgesia2.05266069
17MP0005187_abnormal_penis_morphology1.89060430
18MP0000778_abnormal_nervous_system1.87359477
19MP0005646_abnormal_pituitary_gland1.86957280
20MP0005409_darkened_coat_color1.83644031
21MP0009046_muscle_twitch1.77589748
22MP0002837_dystrophic_cardiac_calcinosis1.75697277
23MP0003183_abnormal_peptide_metabolism1.70974812
24MP0002089_abnormal_postnatal_growth/wei1.66769309
25MP0000579_abnormal_nail_morphology1.59266889
26MP0003868_abnormal_feces_composition1.58632329
27MP0001661_extended_life_span1.57782498
28MP0003635_abnormal_synaptic_transmissio1.57083282
29MP0003566_abnormal_cell_adhesion1.54688055
30MP0003045_fibrosis1.52213673
31MP0005623_abnormal_meninges_morphology1.51367419
32* MP0001486_abnormal_startle_reflex1.50335949
33MP0005248_abnormal_Harderian_gland1.47535028
34MP0000751_myopathy1.46977433
35MP0005275_abnormal_skin_tensile1.40810005
36* MP0002572_abnormal_emotion/affect_behav1.40119321
37MP0004134_abnormal_chest_morphology1.38625608
38MP0004145_abnormal_muscle_electrophysio1.37892791
39MP0002697_abnormal_eye_size1.37671408
40MP0000427_abnormal_hair_cycle1.37389036
41MP0004742_abnormal_vestibular_system1.36204592
42MP0003880_abnormal_central_pattern1.36159820
43MP0009745_abnormal_behavioral_response1.33372909
44MP0001440_abnormal_grooming_behavior1.32813009
45MP0000762_abnormal_tongue_morphology1.32759876
46MP0000534_abnormal_ureter_morphology1.32629141
47MP0000537_abnormal_urethra_morphology1.30024579
48MP0002877_abnormal_melanocyte_morpholog1.28744321
49MP0002557_abnormal_social/conspecific_i1.28137635
50MP0005408_hypopigmentation1.27295334
51MP0002064_seizures1.26574103
52MP0000372_irregular_coat_pigmentation1.26113872
53MP0002108_abnormal_muscle_morphology1.25961635
54MP0003172_abnormal_lysosome_physiology1.25708965
55MP0001485_abnormal_pinna_reflex1.24402416
56MP0001958_emphysema1.23810271
57MP0009384_cardiac_valve_regurgitation1.23782592
58MP0003942_abnormal_urinary_system1.23523590
59MP0000383_abnormal_hair_follicle1.23076333
60MP0001346_abnormal_lacrimal_gland1.22874674
61MP0001502_abnormal_circadian_rhythm1.21602232
62MP0002168_other_aberrant_phenotype1.19583442
63MP0003279_aneurysm1.19400706
64MP0005645_abnormal_hypothalamus_physiol1.18349701
65MP0002177_abnormal_outer_ear1.17711551
66MP0003283_abnormal_digestive_organ1.16403530
67MP0003632_abnormal_nervous_system1.15332681
68MP0005171_absent_coat_pigmentation1.14830866
69MP0003690_abnormal_glial_cell1.14813704
70MP0003890_abnormal_embryonic-extraembry1.14695847
71MP0002272_abnormal_nervous_system1.12773309
72MP0001849_ear_inflammation1.12719021
73MP0000428_abnormal_craniofacial_morphol1.12075084
74MP0002067_abnormal_sensory_capabilities1.10538959
75MP0004885_abnormal_endolymph1.09970582
76MP0000631_abnormal_neuroendocrine_gland1.08918018
77MP0010352_gastrointestinal_tract_polyps1.08736697
78MP0006276_abnormal_autonomic_nervous1.08266229
79MP0003119_abnormal_digestive_system1.08249097
80MP0002102_abnormal_ear_morphology1.08038917
81MP0003935_abnormal_craniofacial_develop1.07943824
82MP0009053_abnormal_anal_canal1.06921492
83MP0003115_abnormal_respiratory_system1.06743937
84MP0000955_abnormal_spinal_cord1.05642704
85MP0004381_abnormal_hair_follicle1.05538585
86MP0009250_abnormal_appendicular_skeleto1.05050646
87MP0004085_abnormal_heartbeat1.04763935
88* MP0002063_abnormal_learning/memory/cond1.04162436
89MP0002116_abnormal_craniofacial_bone1.02812637
90MP0005508_abnormal_skeleton_morphology1.02283199
91MP0003937_abnormal_limbs/digits/tail_de1.02006990
92MP0000920_abnormal_myelination1.01473031
93MP0000049_abnormal_middle_ear1.00516061
94MP0003385_abnormal_body_wall1.00276238
95MP0002233_abnormal_nose_morphology1.00239434
96MP0000733_abnormal_muscle_development0.99537969
97MP0003938_abnormal_ear_development0.99500320
98MP0001293_anophthalmia0.98973314
99MP0000647_abnormal_sebaceous_gland0.98907622
100MP0002693_abnormal_pancreas_physiology0.98125696
101MP0005379_endocrine/exocrine_gland_phen0.97841488
102MP0006292_abnormal_olfactory_placode0.97631777
103MP0002882_abnormal_neuron_morphology0.97330554
104MP0005023_abnormal_wound_healing0.97139134
105MP0000767_abnormal_smooth_muscle0.96133507
106MP0002734_abnormal_mechanical_nocicepti0.96065227
107MP0002928_abnormal_bile_duct0.95480562
108MP0005197_abnormal_uvea_morphology0.95447733
109MP0000749_muscle_degeneration0.94756006
110MP0004084_abnormal_cardiac_muscle0.93351586
111MP0003091_abnormal_cell_migration0.92595989
112MP0003634_abnormal_glial_cell0.91498114
113MP0003252_abnormal_bile_duct0.91196929
114MP0000015_abnormal_ear_pigmentation0.90081900
115MP0001879_abnormal_lymphatic_vessel0.88385983
116MP0003755_abnormal_palate_morphology0.88185256
117MP0005503_abnormal_tendon_morphology0.88124764
118MP0005220_abnormal_exocrine_pancreas0.87906839
119MP0002184_abnormal_innervation0.87295729
120MP0003567_abnormal_fetal_cardiomyocyte0.87059556
121MP0002092_abnormal_eye_morphology0.86199858
122MP0002896_abnormal_bone_mineralization0.84980793
123MP0004510_myositis0.84816682
124MP0003136_yellow_coat_color0.84425326
125MP0003861_abnormal_nervous_system0.84374032
126MP0006138_congestive_heart_failure0.84317042
127MP0000432_abnormal_head_morphology0.84232603
128MP0004133_heterotaxia0.83885070
129MP0001944_abnormal_pancreas_morphology0.83490702
130MP0001177_atelectasis0.83486291
131MP0000678_abnormal_parathyroid_gland0.82988662
132MP0002249_abnormal_larynx_morphology0.81298393
133MP0003137_abnormal_impulse_conducting0.80923164
134MP0004924_abnormal_behavior0.80917878
135MP0005386_behavior/neurological_phenoty0.80917878
136MP0002084_abnormal_developmental_patter0.80337300
137MP0005075_abnormal_melanosome_morpholog0.79061342
138MP0002751_abnormal_autonomic_nervous0.78672170
139MP0004272_abnormal_basement_membrane0.78230594
140MP0002060_abnormal_skin_morphology0.78204753
141MP0002152_abnormal_brain_morphology0.77675359
142MP0001286_abnormal_eye_development0.77480527
143MP0001915_intracranial_hemorrhage0.77356579
144MP0002282_abnormal_trachea_morphology0.76333413
145MP0000371_diluted_coat_color0.76212161
146MP0002295_abnormal_pulmonary_circulatio0.76079859
147MP0005076_abnormal_cell_differentiation0.75884396
148MP0003879_abnormal_hair_cell0.75093993
149MP0003122_maternal_imprinting0.73933790
150MP0002085_abnormal_embryonic_tissue0.73606857
151MP0004215_abnormal_myocardial_fiber0.72960360
152MP0002098_abnormal_vibrissa_morphology0.72504774
153MP0005174_abnormal_tail_pigmentation0.72360653
154MP0004858_abnormal_nervous_system0.72215443
155MP0008775_abnormal_heart_ventricle0.69718647
156MP0000467_abnormal_esophagus_morphology0.67872316
157MP0002932_abnormal_joint_morphology0.67332620
158MP0009672_abnormal_birth_weight0.67037173
159MP0002925_abnormal_cardiovascular_devel0.66231359
160MP0006054_spinal_hemorrhage0.65373585
161MP0004087_abnormal_muscle_fiber0.65336894
162MP0002081_perinatal_lethality0.64794519
163MP0002114_abnormal_axial_skeleton0.63444677
164MP0002109_abnormal_limb_morphology0.62758585

Predicted human phenotypes

RankGene SetZ-score
1Midline defect of the nose (HP:0004122)4.44818289
2Protrusio acetabuli (HP:0003179)3.73580196
3Abnormality of the parietal bone (HP:0002696)3.66741857
4Premature rupture of membranes (HP:0001788)3.61817798
5Abnormality of the nasal septum (HP:0000419)3.29573175
6Alacrima (HP:0000522)3.28537533
7Hypoplastic ischia (HP:0003175)3.20340165
8Abnormality of incisor morphology (HP:0011063)3.20100161
9Depressed nasal tip (HP:0000437)3.19603603
10Neonatal short-limb short stature (HP:0008921)2.99707664
11Trigonocephaly (HP:0000243)2.98564387
12Aplasia involving bones of the extremities (HP:0009825)2.98427328
13Aplasia involving bones of the upper limbs (HP:0009823)2.98427328
14Aplasia of the phalanges of the hand (HP:0009802)2.98427328
15Decreased lacrimation (HP:0000633)2.97627155
16Abnormality of the ischium (HP:0003174)2.88588659
17Nasolacrimal duct obstruction (HP:0000579)2.85876867
18Turricephaly (HP:0000262)2.85471969
19Anteriorly placed anus (HP:0001545)2.84695775
20Anal stenosis (HP:0002025)2.76187907
21Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.72977796
22Arterial tortuosity (HP:0005116)2.70292306
23Vascular tortuosity (HP:0004948)2.69818009
24Aortic dissection (HP:0002647)2.63798450
25Abnormality of the diencephalon (HP:0010662)2.63689115
26Cupped ear (HP:0000378)2.63406680
27Abnormality of the lacrimal duct (HP:0011481)2.59489889
28Mixed hearing impairment (HP:0000410)2.58606854
29Bell-shaped thorax (HP:0001591)2.55263837
30Genetic anticipation (HP:0003743)2.55140216
31Large earlobe (HP:0009748)2.51330852
32Atrophic scars (HP:0001075)2.49162035
33Neoplasm of the heart (HP:0100544)2.47953374
34Short 4th metacarpal (HP:0010044)2.44150413
35Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.44150413
36Abnormality of the nasolacrimal system (HP:0000614)2.42638532
37Absent speech (HP:0001344)2.42462253
38Hypoplastic labia majora (HP:0000059)2.38694133
39Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.37612177
40Aortic aneurysm (HP:0004942)2.37383069
41Narrow palate (HP:0000189)2.35416678
42Intestinal fistula (HP:0100819)2.34958798
43Excessive salivation (HP:0003781)2.33690814
44Drooling (HP:0002307)2.33690814
45Aplasia cutis congenita (HP:0001057)2.32100937
46Abnormality of dentin (HP:0010299)2.29559394
47Morphological abnormality of the middle ear (HP:0008609)2.28820901
48Lip pit (HP:0100267)2.22367490
49Abnormality of the labia majora (HP:0012881)2.22030572
50Ulnar bowing (HP:0003031)2.21083730
51Hypopigmentation of the fundus (HP:0007894)2.15611196
52Natal tooth (HP:0000695)2.14155608
53Abnormality of the antihelix (HP:0009738)2.13763406
54Cerebral aneurysm (HP:0004944)2.10749465
55Aqueductal stenosis (HP:0002410)2.10398935
56Decreased circulating renin level (HP:0003351)2.09848042
57White forelock (HP:0002211)2.09698667
58Febrile seizures (HP:0002373)2.09363027
59Vertebral arch anomaly (HP:0008438)2.09223546
60Blue irides (HP:0000635)2.08912777
61Ankle contracture (HP:0006466)2.07121454
62Limited hip movement (HP:0008800)2.06479964
63Supernumerary ribs (HP:0005815)2.06354040
64Hyperinsulinemic hypoglycemia (HP:0000825)2.04952002
65Bronchomalacia (HP:0002780)2.02643334
66Broad metatarsal (HP:0001783)2.02611051
67Widely spaced teeth (HP:0000687)2.01864104
68Humeroradial synostosis (HP:0003041)2.00784485
69Synostosis involving the elbow (HP:0003938)2.00784485
70Soft skin (HP:0000977)2.00379465
71Submucous cleft hard palate (HP:0000176)2.00101673
72Toxemia of pregnancy (HP:0100603)1.99996699
73Focal motor seizures (HP:0011153)1.99221720
74Abnormality of the fingertips (HP:0001211)1.98595241
75Urethral obstruction (HP:0000796)1.97976317
76Bladder diverticulum (HP:0000015)1.96565393
77Bowel diverticulosis (HP:0005222)1.96543959
78Slow saccadic eye movements (HP:0000514)1.96127471
79Progressive cerebellar ataxia (HP:0002073)1.96097469
80Abnormality of the incisor (HP:0000676)1.95092872
81Mitral valve prolapse (HP:0001634)1.95061549
82Hypoplasia of the iris (HP:0007676)1.93401896
83Labial hypoplasia (HP:0000066)1.93099150
84Spinal rigidity (HP:0003306)1.92782857
85Wide anterior fontanel (HP:0000260)1.92331574
86Abnormality of the columella (HP:0009929)1.90149418
87Hypoglycemic seizures (HP:0002173)1.89644559
88Myelomeningocele (HP:0002475)1.89083638
89Choanal stenosis (HP:0000452)1.87048798
90Cervical subluxation (HP:0003308)1.87015089
91Wormian bones (HP:0002645)1.85843647
92Skin pits (HP:0100276)1.85442877
93Hypoventilation (HP:0002791)1.83857260
94Cutaneous syndactyly (HP:0012725)1.82761266
95Abnormality of salivation (HP:0100755)1.82623483
96Broad face (HP:0000283)1.82351080
97Hyperglycemia (HP:0003074)1.81592909
98Obstructive sleep apnea (HP:0002870)1.79311725
99Abnormality of the distal phalanx of the thumb (HP:0009617)1.78417449
100Overgrowth (HP:0001548)1.77989057
101Neoplasm of the oral cavity (HP:0100649)1.77724344
102Patchy hypopigmentation of hair (HP:0011365)1.77599193
103Bifid scrotum (HP:0000048)1.77493867
104Prolonged QT interval (HP:0001657)1.77360598
105Supernumerary bones of the axial skeleton (HP:0009144)1.77146888
106Anophthalmia (HP:0000528)1.76386650
107Hypoplastic nipples (HP:0002557)1.74867313
108Hypoplastic female external genitalia (HP:0012815)1.74230146
109Macroorchidism (HP:0000053)1.74166678
110Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.71481377
111Bilateral microphthalmos (HP:0007633)1.71340901
112Sparse lateral eyebrow (HP:0005338)1.70237895
113Shallow orbits (HP:0000586)1.69259746
114Syncope (HP:0001279)1.69183106
115Facial cleft (HP:0002006)1.68903040
116Focal seizures (HP:0007359)1.68087479
117Cutaneous finger syndactyly (HP:0010554)1.67633128
118Hyperkalemia (HP:0002153)1.67378306
119Genu recurvatum (HP:0002816)1.66981626
120Insulin-resistant diabetes mellitus (HP:0000831)1.66813958
121Abnormality of the right ventricle (HP:0001707)1.66655196
122Renovascular hypertension (HP:0100817)1.66338752
123Vitreoretinal degeneration (HP:0000655)1.65694475
124Hyperventilation (HP:0002883)1.65488673
125Renal duplication (HP:0000075)1.64731616
126Intellectual disability, moderate (HP:0002342)1.64584915
127Atrial fibrillation (HP:0005110)1.63999869
128Fragile skin (HP:0001030)1.63822112
129Protruding tongue (HP:0010808)1.63492463
130Abnormality of the pubic bones (HP:0003172)1.63047231
131Broad long bones (HP:0005622)1.62398272
132Advanced eruption of teeth (HP:0006288)1.62369158
133Abnormality of the parathyroid morphology (HP:0011766)1.61458590
134Aortic regurgitation (HP:0001659)1.61424172
135Coronal craniosynostosis (HP:0004440)1.61185011
136Epileptic encephalopathy (HP:0200134)1.60440021
137Abnormality of the 4th metacarpal (HP:0010012)1.59522650
138Exostoses (HP:0100777)1.59267258
139Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.59122633
140Degeneration of the lateral corticospinal tracts (HP:0002314)1.59122633
141Recurrent corneal erosions (HP:0000495)1.58529897
142Short nail (HP:0001799)1.58260928
143Arnold-Chiari malformation (HP:0002308)1.57895764
144Abnormal number of incisors (HP:0011064)1.57352827
145Mitral stenosis (HP:0001718)1.57208110
146Hyperacusis (HP:0010780)1.56893573
147Right ventricular cardiomyopathy (HP:0011663)1.56586265
148Laryngomalacia (HP:0001601)1.56232364
149Delayed eruption of teeth (HP:0000684)1.55859336
150Wrist flexion contracture (HP:0001239)1.55039074
151Preaxial foot polydactyly (HP:0001841)1.54851760
152Mitral regurgitation (HP:0001653)1.53297242
153Selective tooth agenesis (HP:0001592)1.52959782
154Hip contracture (HP:0003273)1.51452835
155Broad thumb (HP:0011304)1.49714060
156Hypoplasia of the fovea (HP:0007750)1.49638078
157Aplasia/Hypoplasia of the fovea (HP:0008060)1.49638078
158Mild short stature (HP:0003502)1.49560168
159Pterygium (HP:0001059)1.49219680
160Popliteal pterygium (HP:0009756)1.48033302
161Aplasia/Hypoplasia of the macula (HP:0008059)1.47155020
162Skull defect (HP:0001362)1.45681277
163Cardiovascular calcification (HP:0011915)1.44776832
164Long eyelashes (HP:0000527)1.44557114
165Vertebral clefting (HP:0008428)1.44431455
166Broad phalanx (HP:0006009)1.43938717
167Hyperextensible skin (HP:0000974)1.42888049
168Thin ribs (HP:0000883)1.42198301
169Increased nuchal translucency (HP:0010880)1.40969204
170Partial duplication of the phalanx of hand (HP:0009999)1.40519093
171Tracheal stenosis (HP:0002777)1.40460837
172Midface retrusion (HP:0011800)1.40456809
173Knee flexion contracture (HP:0006380)1.40306099
174Asymmetry of the thorax (HP:0001555)1.39781081
175Abnormal auditory evoked potentials (HP:0006958)1.39425234
176Septo-optic dysplasia (HP:0100842)1.39411907
177Broad finger (HP:0001500)1.37681113
178Hepatoblastoma (HP:0002884)1.36957416

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR3.71082291
2TNIK3.25833594
3LATS13.20229787
4CAMK1G2.61303805
5PDGFRA2.47865797
6NTRK32.26793771
7MET2.16966205
8CASK2.05390027
9TAOK32.05116940
10SIK22.01553828
11CAMK1D2.01342790
12PRPF4B1.99860792
13SIK11.84913430
14FGFR21.79713702
15RIPK11.72892486
16EPHA41.69926072
17DMPK1.69413611
18TTN1.68625706
19MYLK1.64272160
20MARK21.57841999
21MAPK131.56953024
22SGK21.56921428
23CDK121.49677111
24CDC42BPA1.42882940
25EPHB21.40926760
26BRD41.39928257
27MAPK151.39759825
28MST1R1.34942770
29WNK11.32656915
30NUAK11.31437474
31ICK1.30933956
32PKN11.30399361
33PKN21.24294586
34PIK3CA1.23412718
35SGK2231.23407627
36SGK4941.23407627
37MAP3K41.23354122
38SGK31.17656306
39MUSK1.17303336
40EPHA21.15363603
41LMTK21.13904860
42PAK21.12448976
43FGFR11.11452523
44NTRK21.10997084
45MARK11.10646239
46EPHB11.09332795
47PNCK1.08976835
48TYRO31.04663767
49WEE11.04434138
50STK391.04222868
51SGK11.02270930
52PAK41.01960049
53FGFR41.00206431
54SIK30.99877531
55PHKG10.93911316
56PHKG20.93911316
57DAPK20.93201688
58NEK20.92385335
59PRKAA20.91585493
60TTK0.91361073
61TRIB30.89765565
62PDGFRB0.88977426
63ROCK20.88962315
64ERBB40.87835616
65PTK20.87604408
66MAP3K60.87585909
67PAK60.87377158
68WNK40.86815606
69FES0.86624777
70CDK30.85373203
71MOS0.84616118
72MAP2K70.84356200
73EEF2K0.82865412
74FRK0.81172389
75CAMK40.80516762
76LIMK10.79215101
77PRKCE0.79026789
78MELK0.76926471
79PAK30.76762712
80NEK60.75213568
81PRKD20.74565110
82HIPK20.74534143
83MAP3K70.74052018
84OBSCN0.74045609
85STK38L0.73938563
86PRKD30.72558180
87STK380.72305347
88FLT30.71127941
89MAP3K90.69577170
90CSNK1A1L0.68508195
91MAPK70.67589942
92AKT30.67081780
93MTOR0.66059436
94IRAK20.65060851
95CAMK2D0.64589163
96FGR0.64407811
97UHMK10.63790300
98PRKAA10.62807241
99CAMK10.62669653
100CAMK2A0.62561694
101OXSR10.62381587
102BMPR1B0.62223557
103MAP3K130.61588148
104IRAK10.61347946
105CDK50.60960231
106DDR20.60758766
107FER0.59655776
108RPS6KA20.59527145
109ROCK10.59328671
110MAPK100.59044717
111STK240.58679581
112PLK30.58408909
113ERBB20.58351979
114IRAK30.58144991
115PRKG10.56725758
116STK30.56203522
117PRKD10.55657744
118GSK3A0.54328902
119TRPM70.53904380
120DYRK20.52110703
121MKNK20.52107658
122BMX0.51923554
123MAP2K40.50640322
124PRKCH0.50475871
125RIPK40.47938298
126WNK30.47673334
127FGFR30.47536420
128BCR0.47241310
129PRKCG0.46760017
130LATS20.46730343
131CSNK1G10.46377398
132TGFBR20.45297140
133GSK3B0.45100431
134NEK90.44612339
135NTRK10.44430056
136CDK80.43981074
137MKNK10.43534017
138CSNK1E0.43373820
139RPS6KA30.43211362
140TIE10.43027182
141NLK0.42672127
142JAK10.41779390
143PBK0.41745445
144PLK20.41665604
145PTK2B0.41304959
146CSNK1G20.38549071

Predicted pathways (KEGG)

RankGene SetZ-score
1Type II diabetes mellitus_Homo sapiens_hsa049302.38680920
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.13233021
3Hippo signaling pathway_Homo sapiens_hsa043902.08719232
4Nicotine addiction_Homo sapiens_hsa050331.92678569
5Lysine degradation_Homo sapiens_hsa003101.91841905
6Insulin secretion_Homo sapiens_hsa049111.89865342
7Glutamatergic synapse_Homo sapiens_hsa047241.82351306
8Tight junction_Homo sapiens_hsa045301.78891300
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.59483701
10Dilated cardiomyopathy_Homo sapiens_hsa054141.59148500
11Axon guidance_Homo sapiens_hsa043601.58877993
12Circadian entrainment_Homo sapiens_hsa047131.55242964
13Taste transduction_Homo sapiens_hsa047421.52118526
14TGF-beta signaling pathway_Homo sapiens_hsa043501.46055230
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.44232222
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.39418240
17Morphine addiction_Homo sapiens_hsa050321.38924537
18Protein digestion and absorption_Homo sapiens_hsa049741.35549517
19GABAergic synapse_Homo sapiens_hsa047271.34027263
20Cholinergic synapse_Homo sapiens_hsa047251.33478310
21Phosphatidylinositol signaling system_Homo sapiens_hsa040701.31697232
22cAMP signaling pathway_Homo sapiens_hsa040241.30778613
23Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29825028
24Serotonergic synapse_Homo sapiens_hsa047261.29205724
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.28783138
26Basal cell carcinoma_Homo sapiens_hsa052171.28588817
27Ovarian steroidogenesis_Homo sapiens_hsa049131.22926119
28Vitamin B6 metabolism_Homo sapiens_hsa007501.20859911
29Amphetamine addiction_Homo sapiens_hsa050311.19889699
30Long-term potentiation_Homo sapiens_hsa047201.16870381
31Renin secretion_Homo sapiens_hsa049241.16075984
32Calcium signaling pathway_Homo sapiens_hsa040201.15662856
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15048928
34Cocaine addiction_Homo sapiens_hsa050301.14795297
35Hedgehog signaling pathway_Homo sapiens_hsa043401.14280930
36Complement and coagulation cascades_Homo sapiens_hsa046101.12106961
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.07769763
38Dorso-ventral axis formation_Homo sapiens_hsa043201.07035655
39Long-term depression_Homo sapiens_hsa047301.06845875
40ErbB signaling pathway_Homo sapiens_hsa040121.06658493
41Carbohydrate digestion and absorption_Homo sapiens_hsa049731.06497808
42Steroid biosynthesis_Homo sapiens_hsa001001.06157613
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.05845457
44Small cell lung cancer_Homo sapiens_hsa052221.04011512
45Dopaminergic synapse_Homo sapiens_hsa047281.02667303
46Salivary secretion_Homo sapiens_hsa049701.02308046
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02251328
48Circadian rhythm_Homo sapiens_hsa047101.01561858
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01422833
50Choline metabolism in cancer_Homo sapiens_hsa052311.01281181
51Oxytocin signaling pathway_Homo sapiens_hsa049211.00001865
52GnRH signaling pathway_Homo sapiens_hsa049120.99942983
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98602433
54cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97446221
55Wnt signaling pathway_Homo sapiens_hsa043100.95625048
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.94787240
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93933795
58Melanoma_Homo sapiens_hsa052180.93287423
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92814957
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92325933
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.91935517
62Amoebiasis_Homo sapiens_hsa051460.90384495
63Ether lipid metabolism_Homo sapiens_hsa005650.90309391
64Gastric acid secretion_Homo sapiens_hsa049710.89570075
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.89127583
66Ras signaling pathway_Homo sapiens_hsa040140.86604698
67Notch signaling pathway_Homo sapiens_hsa043300.86158905
68Prostate cancer_Homo sapiens_hsa052150.84627669
69Pancreatic secretion_Homo sapiens_hsa049720.82897856
70Pathways in cancer_Homo sapiens_hsa052000.82842780
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.82329689
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81313123
73PI3K-Akt signaling pathway_Homo sapiens_hsa041510.80741069
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80646063
75ABC transporters_Homo sapiens_hsa020100.79692189
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79554075
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.79256719
78Butanoate metabolism_Homo sapiens_hsa006500.79108352
79Tyrosine metabolism_Homo sapiens_hsa003500.79013592
80Thyroid cancer_Homo sapiens_hsa052160.78924743
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76008856
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75985266
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75795707
84Estrogen signaling pathway_Homo sapiens_hsa049150.75731936
85MAPK signaling pathway_Homo sapiens_hsa040100.75416047
86Olfactory transduction_Homo sapiens_hsa047400.74898827
87Synaptic vesicle cycle_Homo sapiens_hsa047210.74004642
88Insulin resistance_Homo sapiens_hsa049310.73469584
89Histidine metabolism_Homo sapiens_hsa003400.73232529
90Adherens junction_Homo sapiens_hsa045200.72690388
91Renal cell carcinoma_Homo sapiens_hsa052110.72646667
92ECM-receptor interaction_Homo sapiens_hsa045120.71985094
93Glioma_Homo sapiens_hsa052140.71849271
94Melanogenesis_Homo sapiens_hsa049160.71176442
95Glucagon signaling pathway_Homo sapiens_hsa049220.70776387
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69112770
97Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68906184
98Prion diseases_Homo sapiens_hsa050200.68899632
99Fatty acid elongation_Homo sapiens_hsa000620.67930738
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67847184
101Inositol phosphate metabolism_Homo sapiens_hsa005620.65821100
102Oocyte meiosis_Homo sapiens_hsa041140.65050754
103Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64565411
104Rap1 signaling pathway_Homo sapiens_hsa040150.63410206
105AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62968569
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62886058
107Focal adhesion_Homo sapiens_hsa045100.61560199
108Endometrial cancer_Homo sapiens_hsa052130.61091084
109Collecting duct acid secretion_Homo sapiens_hsa049660.60307721
110MicroRNAs in cancer_Homo sapiens_hsa052060.59171712
111Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58716215
112Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58199180
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57790468
114Arginine biosynthesis_Homo sapiens_hsa002200.55912541
115Sphingolipid metabolism_Homo sapiens_hsa006000.54051915
116mTOR signaling pathway_Homo sapiens_hsa041500.51795160
117AMPK signaling pathway_Homo sapiens_hsa041520.51749083
118Gap junction_Homo sapiens_hsa045400.51665417
119Cardiac muscle contraction_Homo sapiens_hsa042600.51589973
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50857288
121Insulin signaling pathway_Homo sapiens_hsa049100.50693809
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49866962
123Bile secretion_Homo sapiens_hsa049760.49611000
124Thyroid hormone synthesis_Homo sapiens_hsa049180.49567660
125Cell cycle_Homo sapiens_hsa041100.48185500
126Fatty acid metabolism_Homo sapiens_hsa012120.47958580
127Sulfur metabolism_Homo sapiens_hsa009200.46539110
128Prolactin signaling pathway_Homo sapiens_hsa049170.46053070
129Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45933947
130Adipocytokine signaling pathway_Homo sapiens_hsa049200.45858406
131Vibrio cholerae infection_Homo sapiens_hsa051100.45761863
132Fatty acid biosynthesis_Homo sapiens_hsa000610.45035802
133Proteoglycans in cancer_Homo sapiens_hsa052050.44508010
134mRNA surveillance pathway_Homo sapiens_hsa030150.42653440
135Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42366648

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