NATD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1oxygen transport (GO:0015671)7.96149163
2gas transport (GO:0015669)6.90773157
3protoporphyrinogen IX metabolic process (GO:0046501)6.70233411
4hemoglobin metabolic process (GO:0020027)5.99281427
5erythrocyte development (GO:0048821)5.50391612
6porphyrin-containing compound biosynthetic process (GO:0006779)5.33292508
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.20209789
8negative regulation of cell killing (GO:0031342)5.20209789
9erythrocyte maturation (GO:0043249)5.15057859
10protoporphyrinogen IX biosynthetic process (GO:0006782)4.99650832
11piRNA metabolic process (GO:0034587)4.77444748
12tetrapyrrole biosynthetic process (GO:0033014)4.65635945
13modulation by symbiont of host defense response (GO:0052031)4.51811718
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.51811718
15modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.51811718
16positive regulation by organism of defense response of other organism involved in symbiotic interact4.51811718
17modulation by symbiont of host immune response (GO:0052553)4.51811718
18positive regulation by symbiont of host defense response (GO:0052509)4.51811718
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.47371754
20regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.44193713
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.39557994
22porphyrin-containing compound metabolic process (GO:0006778)4.38188271
23negative regulation of erythrocyte differentiation (GO:0045647)4.23768495
24neutrophil activation involved in immune response (GO:0002283)4.14664048
25myeloid cell development (GO:0061515)4.13768147
26antigen processing and presentation of endogenous antigen (GO:0019883)4.07098572
27heme biosynthetic process (GO:0006783)4.00726801
28detection of other organism (GO:0098543)4.00297733
29antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.93473184
303-UTR-mediated mRNA stabilization (GO:0070935)3.91096358
31paraxial mesoderm development (GO:0048339)3.86662365
32detection of bacterium (GO:0016045)3.85834719
33mitotic chromosome condensation (GO:0007076)3.82754211
34mitotic metaphase plate congression (GO:0007080)3.82182068
35positive regulation of gamma-delta T cell activation (GO:0046645)3.81875838
36protein localization to kinetochore (GO:0034501)3.73762237
37leukocyte migration involved in inflammatory response (GO:0002523)3.61549833
38mitotic sister chromatid segregation (GO:0000070)3.60611312
39DNA replication-dependent nucleosome assembly (GO:0006335)3.57957900
40DNA replication-dependent nucleosome organization (GO:0034723)3.57957900
41leukocyte aggregation (GO:0070486)3.54591631
42negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.54547779
43histone H2A monoubiquitination (GO:0035518)3.53393044
44positive regulation of chromosome segregation (GO:0051984)3.53225873
45regulation of exit from mitosis (GO:0007096)3.53116451
46protein localization to chromosome, centromeric region (GO:0071459)3.50807422
47neutrophil activation (GO:0042119)3.48781742
48negative regulation of cAMP-mediated signaling (GO:0043951)3.47448214
49regulation of spindle organization (GO:0090224)3.46463149
50DNA damage response, signal transduction resulting in transcription (GO:0042772)3.44340427
51regulation of hippo signaling (GO:0035330)3.42651947
52granulocyte activation (GO:0036230)3.42587204
53gene silencing by RNA (GO:0031047)3.40841660
54sister chromatid segregation (GO:0000819)3.40724342
55regulation of sister chromatid cohesion (GO:0007063)3.39720286
56regulation of response to osmotic stress (GO:0047484)3.39385210
57macrophage activation involved in immune response (GO:0002281)3.39031323
58negative regulation of lymphocyte mediated immunity (GO:0002707)3.33376041
59response to peptidoglycan (GO:0032494)3.32790122
60heme metabolic process (GO:0042168)3.31750209
61DNA methylation involved in gamete generation (GO:0043046)3.31263957
62regulation of female gonad development (GO:2000194)3.30866749
63detection of external biotic stimulus (GO:0098581)3.29240083
64mitotic nuclear envelope disassembly (GO:0007077)3.28142355
65DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.27331478
66regulation of interferon-beta biosynthetic process (GO:0045357)3.25125530
67regulation of mast cell degranulation (GO:0043304)3.24159099
68cellular extravasation (GO:0045123)3.20796284
69microtubule depolymerization (GO:0007019)3.20011770
70regulation of B cell receptor signaling pathway (GO:0050855)3.17103578
71protein localization to chromosome (GO:0034502)3.16864961
72negative regulation of histone methylation (GO:0031061)3.16594749
73regulation of platelet aggregation (GO:0090330)3.15061516
74response to host immune response (GO:0052572)3.14403901
75response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.14403901
76notochord development (GO:0030903)3.14309456
77modulation by virus of host process (GO:0019054)3.14303433
78response to interleukin-15 (GO:0070672)3.13769796
79negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.11285766
80synaptonemal complex assembly (GO:0007130)3.11102614
81negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.10796614
82regulation of chromosome segregation (GO:0051983)3.09717170
83metaphase plate congression (GO:0051310)3.08532717
84response to methylmercury (GO:0051597)3.06885600
85cytoplasmic mRNA processing body assembly (GO:0033962)3.06231555
86DNA alkylation (GO:0006305)3.03817260
87DNA methylation (GO:0006306)3.03817260
88negative regulation of leukocyte mediated immunity (GO:0002704)3.02595931
89glycine transport (GO:0015816)3.01659824
90membrane disassembly (GO:0030397)3.01640718
91nuclear envelope disassembly (GO:0051081)3.01640718
92cellular response to virus (GO:0098586)3.00590759
93detection of molecule of bacterial origin (GO:0032490)3.00367186
94neutrophil mediated immunity (GO:0002446)2.98386847
95negative regulation of interleukin-12 production (GO:0032695)2.97664669
96positive regulation of fibroblast migration (GO:0010763)2.95526842
97respiratory burst (GO:0045730)2.95297536
98pre-miRNA processing (GO:0031054)2.95258883
99regulation of RNA export from nucleus (GO:0046831)2.94850086
100negative regulation of chromosome segregation (GO:0051985)2.94654169
101spindle checkpoint (GO:0031577)2.92795071
102positive regulation of SMAD protein import into nucleus (GO:0060391)2.90918057
103regulation of gamma-delta T cell activation (GO:0046643)2.90807182
104regulation of mast cell activation involved in immune response (GO:0033006)2.90493161
105positive thymic T cell selection (GO:0045059)2.89090129
106resolution of meiotic recombination intermediates (GO:0000712)2.88385839
107attachment of spindle microtubules to kinetochore (GO:0008608)2.88210623
108negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.87844231
109regulation of sequestering of triglyceride (GO:0010889)2.87721992
110detection of biotic stimulus (GO:0009595)2.87654035
111response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.86882164
112response to host (GO:0075136)2.86882164
113response to host defenses (GO:0052200)2.86882164
114female gamete generation (GO:0007292)2.86698514
115mitotic spindle checkpoint (GO:0071174)2.85628344
116regulation of SMAD protein import into nucleus (GO:0060390)2.85371692
117mitotic spindle assembly checkpoint (GO:0007094)2.84973179
118negative regulation of sister chromatid segregation (GO:0033046)2.84855136
119negative regulation of mitotic sister chromatid separation (GO:2000816)2.84855136
120negative regulation of mitotic sister chromatid segregation (GO:0033048)2.84855136
121negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.84855136
122protein K6-linked ubiquitination (GO:0085020)2.83762954
123regulation of mitotic spindle organization (GO:0060236)2.83132858
124regulation of myeloid leukocyte mediated immunity (GO:0002886)2.82419286
125regulation of transforming growth factor beta2 production (GO:0032909)2.81915843
126regulation of gene silencing by RNA (GO:0060966)2.81725331
127regulation of posttranscriptional gene silencing (GO:0060147)2.81725331
128regulation of gene silencing by miRNA (GO:0060964)2.81725331
129regulation of telomere maintenance via telomerase (GO:0032210)2.81605090
130negative regulation of glial cell proliferation (GO:0060253)2.81345281
131regulation of necroptotic process (GO:0060544)2.80991688
132hippo signaling (GO:0035329)2.80304154
133positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.80154148
134positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.80154148
135positive regulation of mitotic sister chromatid separation (GO:1901970)2.80154148
136megakaryocyte development (GO:0035855)2.79631832
137gene silencing (GO:0016458)2.78212497
138protein targeting to plasma membrane (GO:0072661)2.77935816
139modulation by symbiont of host cellular process (GO:0044068)2.77888402
140spindle assembly checkpoint (GO:0071173)2.77833875
141positive regulation of protein homooligomerization (GO:0032464)2.76883732
142histone H2A ubiquitination (GO:0033522)2.76661656
143cellular response to interleukin-15 (GO:0071350)2.76278109
144regulation of leukocyte degranulation (GO:0043300)2.75754928
145regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.75748358
146positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.75399174
147regulation of meiosis I (GO:0060631)2.74758439
148positive regulation of Rap GTPase activity (GO:0032854)2.74751446
149DNA replication checkpoint (GO:0000076)2.73243998
150regulation of mitotic metaphase/anaphase transition (GO:0030071)2.73173101
151granulocyte differentiation (GO:0030851)2.72608015
152germinal center formation (GO:0002467)2.72431008
153synaptonemal complex organization (GO:0070193)2.71486632
154positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.71343675
155mitotic sister chromatid cohesion (GO:0007064)2.71134179
156negative regulation of phagocytosis (GO:0050765)2.71016385
157meiotic cell cycle (GO:0051321)2.67936424
158positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.67252972
159male meiosis (GO:0007140)2.66303665
160regulation of retinoic acid receptor signaling pathway (GO:0048385)2.65795478
161DNA damage induced protein phosphorylation (GO:0006975)2.65785436
162mitochondrion degradation (GO:0000422)2.65521506
163negative regulation of DNA-templated transcription, elongation (GO:0032785)2.65408161
164negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.65408161
165nuclear envelope organization (GO:0006998)2.65391249
166regulation of gamma-delta T cell differentiation (GO:0045586)2.65180150
167microglial cell activation (GO:0001774)2.64437096
168intracellular estrogen receptor signaling pathway (GO:0030520)2.63980835
169positive regulation of granulocyte differentiation (GO:0030854)2.62634203
170establishment of chromosome localization (GO:0051303)2.62284898
171negative regulation of necroptotic process (GO:0060546)2.61600120
172chromosome segregation (GO:0007059)2.60852160
173regulation of mitotic sister chromatid separation (GO:0010965)2.58773036
174regulation of mitotic sister chromatid segregation (GO:0033047)2.58773036
175regulation of sister chromatid segregation (GO:0033045)2.58773036
176positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.58454664
177tetrapyrrole metabolic process (GO:0033013)2.58280020
178myeloid cell activation involved in immune response (GO:0002275)2.58151341
179negative regulation of innate immune response (GO:0045824)2.58146024
180DNA replication-independent nucleosome assembly (GO:0006336)2.57981840
181DNA replication-independent nucleosome organization (GO:0034724)2.57981840
182oocyte maturation (GO:0001556)2.57921065
183phosphatidylethanolamine biosynthetic process (GO:0006646)2.56176994
184negative regulation of execution phase of apoptosis (GO:1900118)2.56125976
185monoubiquitinated protein deubiquitination (GO:0035520)2.55991947
186negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.55578695
187regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.54994523
188negative regulation of T cell mediated immunity (GO:0002710)2.54607179
189macrophage activation (GO:0042116)2.54196950
190regulation of meiosis (GO:0040020)2.53828355
191leukocyte degranulation (GO:0043299)2.53361018
192DNA methylation or demethylation (GO:0044728)2.50867576
193protein complex localization (GO:0031503)2.49627840
194lung-associated mesenchyme development (GO:0060484)2.48127933
195microtubule polymerization or depolymerization (GO:0031109)2.47000649
196negative regulation of mitosis (GO:0045839)2.46059289
197regulation of centrosome cycle (GO:0046605)2.46053009
198positive regulation of gene expression, epigenetic (GO:0045815)2.44484652
199nuclear pore complex assembly (GO:0051292)2.44448739
200meiotic nuclear division (GO:0007126)2.43006387

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.82733415
2E2F7_22180533_ChIP-Seq_HELA_Human5.46562403
3GATA1_19941826_ChIP-Seq_K562_Human3.82734772
4GATA1_22025678_ChIP-Seq_K562_Human3.64332042
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.50472357
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.13576741
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.87697252
8AR_21909140_ChIP-Seq_LNCAP_Human2.86349247
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.81719394
10NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.75456060
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.74809908
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.73720386
13VDR_21846776_ChIP-Seq_THP-1_Human2.70108149
14GATA1_19941827_ChIP-Seq_MEL_Mouse2.69018950
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.67247517
16SCL_19346495_ChIP-Seq_HPC-7_Human2.66945717
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.65496999
18KDM2B_26808549_Chip-Seq_SUP-B15_Human2.52693304
19TCF7_22412390_ChIP-Seq_EML_Mouse2.52295412
20TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.36517953
21GATA2_19941826_ChIP-Seq_K562_Human2.34905551
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.32955337
23IRF8_22096565_ChIP-ChIP_GC-B_Human2.25769784
24KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.23757968
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.17668059
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.17246347
27VDR_24763502_ChIP-Seq_THP-1_Human2.17176992
28MAF_26560356_Chip-Seq_TH1_Human2.15753780
29CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.11074567
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.06841456
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.06200223
32KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.03572567
33KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse2.03431664
34TP63_19390658_ChIP-ChIP_HaCaT_Human2.03183571
35NANOG_21062744_ChIP-ChIP_HESCs_Human2.01624044
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.99833123
37KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.99134954
38POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.98134387
39ELK3_25401928_ChIP-Seq_HUVEC_Human1.97663868
40UTX_26944678_Chip-Seq_JUKART_Human1.97351173
41ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.97151082
42SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.96002771
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.95147673
44SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.94790362
45SPI1_23127762_ChIP-Seq_K562_Human1.93841279
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.88431893
47LXR_22292898_ChIP-Seq_THP-1_Human1.87590592
48MYC_18555785_ChIP-Seq_MESCs_Mouse1.86487249
49MYB_21317192_ChIP-Seq_ERMYB_Mouse1.86189600
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.83089729
51CTCF_27219007_Chip-Seq_ERYTHROID_Human1.82534199
52BRD4_27068464_Chip-Seq_AML-cells_Mouse1.80311906
53SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.79543030
54GATA1_22383799_ChIP-Seq_G1ME_Mouse1.79523389
55MYCN_18555785_ChIP-Seq_MESCs_Mouse1.77592128
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.77526702
57KDM2B_26808549_Chip-Seq_K562_Human1.74469106
58SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.73966484
59IRF8_27001747_Chip-Seq_BMDM_Mouse1.72568197
60NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.71710114
61MYC_19079543_ChIP-ChIP_MESCs_Mouse1.71180443
62SOX2_18555785_ChIP-Seq_MESCs_Mouse1.70790234
63RUNX_20019798_ChIP-Seq_JUKART_Human1.70414048
64SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.70048023
65MAF_26560356_Chip-Seq_TH2_Human1.69207777
66GATA1_26923725_Chip-Seq_HPCs_Mouse1.68941495
67RARG_19884340_ChIP-ChIP_MEFs_Mouse1.68651423
68MYC_22102868_ChIP-Seq_BL_Human1.67956252
69ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.67880048
70KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.65610110
71KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.65610110
72KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.65610110
73CIITA_25753668_ChIP-Seq_RAJI_Human1.64517970
74FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.64270063
75LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.62920919
76MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.62665336
77KDM2B_26808549_Chip-Seq_JURKAT_Human1.61825035
78KLF4_18555785_ChIP-Seq_MESCs_Mouse1.61562804
79TCF3_18692474_ChIP-Seq_MEFs_Mouse1.58552786
80GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.57337994
81E2F1_21310950_ChIP-Seq_MCF-7_Human1.56227983
82TCF3_18692474_ChIP-Seq_MESCs_Mouse1.54886323
83HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.54421019
84POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.54130448
85MYC_19030024_ChIP-ChIP_MESCs_Mouse1.54007142
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.53777110
87NCOR1_26117541_ChIP-Seq_K562_Human1.52340486
88LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.51674500
89EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.50244397
90CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.48237803
91SA1_27219007_Chip-Seq_ERYTHROID_Human1.47656567
92E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.47531052
93VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.46550591
94GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.45715633
95CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.45580752
96GATA2_22383799_ChIP-Seq_G1ME_Mouse1.44088751
97EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.43636602
98GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.43385994
99NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.43219882
100CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.42952651
101SPI1_23547873_ChIP-Seq_NB4_Human1.40379684
102NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.39652009
103RACK7_27058665_Chip-Seq_MCF-7_Human1.39411494
104XRN2_22483619_ChIP-Seq_HELA_Human1.38336639
105TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.37401309
106BCL6_27268052_Chip-Seq_Bcells_Human1.36983279
107TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36953787
108BCOR_27268052_Chip-Seq_Bcells_Human1.36780673
109TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.36493366
110IRF8_21731497_ChIP-ChIP_J774_Mouse1.36301669
111PPARA_22158963_ChIP-Seq_LIVER_Mouse1.36205652
112IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.35791174
113SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.35358198
114P68_20966046_ChIP-Seq_HELA_Human1.34338143
115KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.33854752
116MYC_18358816_ChIP-ChIP_MESCs_Mouse1.32629199
117NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.29611907
118STAT4_19710469_ChIP-ChIP_TH1__Mouse1.27175000
119Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.24981797
120CTCF_21964334_ChIP-Seq_BJAB-B_Human1.24559976
121MYB_26560356_Chip-Seq_TH1_Human1.24095894
122POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24017003
123MYB_26560356_Chip-Seq_TH2_Human1.22105843
124TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21980918
125ELF1_20517297_ChIP-Seq_JURKAT_Human1.21735772
126CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20575578
127SOX2_18692474_ChIP-Seq_MESCs_Mouse1.20492578
128CREB1_15753290_ChIP-ChIP_HEK293T_Human1.20432437
129FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.20420883
130ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19876491
131E2F1_18555785_ChIP-Seq_MESCs_Mouse1.19219539
132PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19188263
133FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.18828465
134EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.18699717
135FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.17799562
136ZNF263_19887448_ChIP-Seq_K562_Human1.17556691
137ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16635971
138DNAJC2_21179169_ChIP-ChIP_NT2_Human1.16525935
139KDM5A_27292631_Chip-Seq_BREAST_Human1.16320042
140RXR_22158963_ChIP-Seq_LIVER_Mouse1.16028384
141TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15602374
142E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15482522
143GABP_19822575_ChIP-Seq_HepG2_Human1.15259470
144PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.14782640
145PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14470530
146POU5F1_16518401_ChIP-PET_MESCs_Mouse1.13941665
147KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13536229
148SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.12776388
149ETS1_20019798_ChIP-Seq_JURKAT_Human1.12554543
150TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12209629
151CTCF_21964334_Chip-Seq_Bcells_Human1.11777986
152NANOG_18692474_ChIP-Seq_MESCs_Mouse1.11266375
153YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10849892
154CHD1_26751641_Chip-Seq_LNCaP_Human1.10542419
155EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09755518
156P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08886383
157SOX2_16153702_ChIP-ChIP_HESCs_Human1.08437504
158CREB1_26743006_Chip-Seq_LNCaP_Human1.08230057
159EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07255175
160ISL1_27105846_Chip-Seq_CPCs_Mouse1.06811165
161STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.06399278
162SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06302717
163SOX2_18692474_ChIP-Seq_MEFs_Mouse1.05905888
164POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.05667985
165SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04525473
166PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.03786198
167CLOCK_20551151_ChIP-Seq_293T_Human1.01959024
168TP53_22127205_ChIP-Seq_IMR90_Human1.01785626
169GATA3_27048872_Chip-Seq_THYMUS_Human1.01572340
170FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.00829153
171NANOG_18692474_ChIP-Seq_MEFs_Mouse1.00382540
172SMC4_20622854_ChIP-Seq_HELA_Human0.99564353
173CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99275508
174SA1_27219007_Chip-Seq_Bcells_Human0.99178852
175SALL4_18804426_ChIP-ChIP_XEN_Mouse0.99135111
176KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99075025
177SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99019396
178TFEB_21752829_ChIP-Seq_HELA_Human0.98113127
179STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98083481
180CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.97998915
181PU_27001747_Chip-Seq_BMDM_Mouse0.97947614
182ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97903268
183ATF3_27146783_Chip-Seq_COLON_Human0.96836820
184POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.96536772
185OCT4_19829295_ChIP-Seq_ESCs_Human0.96406169
186KAP1_27257070_Chip-Seq_ESCs_Mouse0.95924753
187NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95713898
188PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95600173
189CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95562338
190EGR1_19374776_ChIP-ChIP_THP-1_Human0.95545366
191SPI1_20517297_ChIP-Seq_HL60_Human0.95105423
192HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.94918183
193EST1_17652178_ChIP-ChIP_JURKAT_Human0.94082951
194KDM2B_26808549_Chip-Seq_DND41_Human0.93883030

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level5.14827601
2MP0005083_abnormal_biliary_tract3.79576853
3MP0003724_increased_susceptibility_to3.61192531
4MP0003303_peritoneal_inflammation3.43287006
5MP0002653_abnormal_ependyma_morphology3.29919885
6MP0003436_decreased_susceptibility_to2.89544752
7MP0003111_abnormal_nucleus_morphology2.63634321
8MP0004130_abnormal_muscle_cell2.58107936
9MP0003077_abnormal_cell_cycle2.51242071
10MP0003718_maternal_effect2.47786291
11MP0010094_abnormal_chromosome_stability2.45032121
12MP0003693_abnormal_embryo_hatching2.44063693
13MP0008438_abnormal_cutaneous_collagen2.40838718
14MP0004957_abnormal_blastocyst_morpholog2.40005015
15MP0001545_abnormal_hematopoietic_system2.38680254
16MP0005397_hematopoietic_system_phenotyp2.38680254
17MP0003191_abnormal_cellular_cholesterol2.34134115
18MP0009278_abnormal_bone_marrow2.24534500
19MP0010030_abnormal_orbit_morphology2.16709198
20MP0000685_abnormal_immune_system2.15451913
21MP0000537_abnormal_urethra_morphology2.08557098
22MP0000749_muscle_degeneration2.08034330
23MP0001730_embryonic_growth_arrest2.07675108
24MP0003878_abnormal_ear_physiology2.06334194
25MP0005377_hearing/vestibular/ear_phenot2.06334194
26MP0004145_abnormal_muscle_electrophysio2.00901986
27MP0002419_abnormal_innate_immunity1.97878138
28MP0008877_abnormal_DNA_methylation1.92130756
29MP0004185_abnormal_adipocyte_glucose1.91099473
30MP0002085_abnormal_embryonic_tissue1.89071712
31MP0003937_abnormal_limbs/digits/tail_de1.84431749
32MP0005025_abnormal_response_to1.84211709
33MP0003828_pulmonary_edema1.80952709
34MP0008932_abnormal_embryonic_tissue1.79973656
35MP0005380_embryogenesis_phenotype1.79472984
36MP0001672_abnormal_embryogenesis/_devel1.79472984
37MP0003123_paternal_imprinting1.77804301
38MP0002084_abnormal_developmental_patter1.76274197
39MP0000350_abnormal_cell_proliferation1.76091948
40MP0005076_abnormal_cell_differentiation1.75682277
41MP0003121_genomic_imprinting1.75677578
42MP0001697_abnormal_embryo_size1.68793556
43MP0002132_abnormal_respiratory_system1.67322701
44MP0003315_abnormal_perineum_morphology1.64905266
45MP0001849_ear_inflammation1.63134206
46MP0003984_embryonic_growth_retardation1.62503733
47MP0001835_abnormal_antigen_presentation1.62196325
48MP0003705_abnormal_hypodermis_morpholog1.61351974
49MP0002088_abnormal_embryonic_growth/wei1.59138840
50MP0001790_abnormal_immune_system1.59063449
51MP0005387_immune_system_phenotype1.59063449
52MP0003172_abnormal_lysosome_physiology1.55862189
53MP0005464_abnormal_platelet_physiology1.55136117
54MP0000733_abnormal_muscle_development1.53873945
55MP0005000_abnormal_immune_tolerance1.52760675
56MP0003890_abnormal_embryonic-extraembry1.52667237
57MP0009785_altered_susceptibility_to1.51392465
58MP0002210_abnormal_sex_determination1.50895370
59MP0002420_abnormal_adaptive_immunity1.48944589
60MP0002249_abnormal_larynx_morphology1.47704307
61MP0001819_abnormal_immune_cell1.47015824
62MP0000751_myopathy1.45220069
63MP0002405_respiratory_system_inflammati1.43341651
64MP0003119_abnormal_digestive_system1.43191075
65MP0001929_abnormal_gametogenesis1.40469279
66MP0002332_abnormal_exercise_endurance1.39969192
67MP0002398_abnormal_bone_marrow1.38550860
68MP0001800_abnormal_humoral_immune1.36254511
69MP0001533_abnormal_skeleton_physiology1.33824765
70MP0004197_abnormal_fetal_growth/weight/1.31911279
71MP0002723_abnormal_immune_serum1.31108404
72MP0000534_abnormal_ureter_morphology1.29936061
73MP0000747_muscle_weakness1.29800030
74MP0000428_abnormal_craniofacial_morphol1.29184287
75MP0000653_abnormal_sex_gland1.29098532
76MP0003755_abnormal_palate_morphology1.27188034
77MP0003300_gastrointestinal_ulcer1.27136196
78MP0003045_fibrosis1.26655468
79MP0003942_abnormal_urinary_system1.26569437
80MP0000003_abnormal_adipose_tissue1.26353604
81MP0002086_abnormal_extraembryonic_tissu1.25353158
82MP0009333_abnormal_splenocyte_physiolog1.25228638
83MP0000759_abnormal_skeletal_muscle1.24353152
84MP0005275_abnormal_skin_tensile1.23778880
85MP0001145_abnormal_male_reproductive1.23543439
86MP0003763_abnormal_thymus_physiology1.22471252
87MP0003935_abnormal_craniofacial_develop1.22196777
88MP0005395_other_phenotype1.21941123
89MP0008007_abnormal_cellular_replicative1.21772634
90MP0002080_prenatal_lethality1.21614694
91MP0000689_abnormal_spleen_morphology1.20784178
92MP0002722_abnormal_immune_system1.20428154
93MP0001293_anophthalmia1.19887953
94MP0008057_abnormal_DNA_replication1.19570049
95MP0002452_abnormal_antigen_presenting1.19566345
96MP0006082_CNS_inflammation1.19385233
97MP0002932_abnormal_joint_morphology1.18867855
98MP0004510_myositis1.18710392
99MP0003656_abnormal_erythrocyte_physiolo1.18565114
100MP0003646_muscle_fatigue1.18283133
101MP0002106_abnormal_muscle_physiology1.18077276
102MP0004264_abnormal_extraembryonic_tissu1.17803806
103MP0004233_abnormal_muscle_weight1.17792066
104MP0000432_abnormal_head_morphology1.15852911
105MP0003115_abnormal_respiratory_system1.15661126
106MP0003699_abnormal_female_reproductive1.15521162
107MP0003861_abnormal_nervous_system1.15282706
108MP0003221_abnormal_cardiomyocyte_apopto1.14994484
109MP0009053_abnormal_anal_canal1.14320600
110MP0009764_decreased_sensitivity_to1.12999594
111MP0000462_abnormal_digestive_system1.12405960
112MP0004381_abnormal_hair_follicle1.11150470
113MP0005671_abnormal_response_to1.10524332
114MP0002116_abnormal_craniofacial_bone1.08740024
115MP0008004_abnormal_stomach_pH1.08632950
116MP0004087_abnormal_muscle_fiber1.08276654
117MP0009384_cardiac_valve_regurgitation1.08233255
118MP0000716_abnormal_immune_system1.07848844
119MP0005508_abnormal_skeleton_morphology1.06961861
120MP0002282_abnormal_trachea_morphology1.05991535
121MP0002111_abnormal_tail_morphology1.05619086
122MP0004947_skin_inflammation1.05339923
123MP0004272_abnormal_basement_membrane1.04725297
124MP0005503_abnormal_tendon_morphology1.03076576
125MP0000566_synostosis1.01513433
126MP0001119_abnormal_female_reproductive1.01326196
127MP0003567_abnormal_fetal_cardiomyocyte1.01137955
128MP0002429_abnormal_blood_cell1.00658112
129MP0005451_abnormal_body_composition1.00126894
130MP0003950_abnormal_plasma_membrane0.99734956
131MP0002971_abnormal_brown_adipose0.98024618
132MP0002102_abnormal_ear_morphology0.98008311
133MP0000703_abnormal_thymus_morphology0.97644972
134MP0005369_muscle_phenotype0.97626489
135MP0004084_abnormal_cardiac_muscle0.97253911
136MP0003879_abnormal_hair_cell0.96492060
137MP0001286_abnormal_eye_development0.96111569
138MP0005257_abnormal_intraocular_pressure0.94865806
139MP0005375_adipose_tissue_phenotype0.92971616
140MP0002092_abnormal_eye_morphology0.92424494
141MP0002138_abnormal_hepatobiliary_system0.92396127
142MP0009250_abnormal_appendicular_skeleto0.92371690
143MP0002925_abnormal_cardiovascular_devel0.91645367
144MP0002233_abnormal_nose_morphology0.91530003
145MP0008058_abnormal_DNA_repair0.90848210
146MP0004133_heterotaxia0.90529811
147MP0002161_abnormal_fertility/fecundity0.90138857
148MP0002148_abnormal_hypersensitivity_rea0.89385178
149MP0005666_abnormal_adipose_tissue0.89091895
150MP0000858_altered_metastatic_potential0.88981675
151MP0008789_abnormal_olfactory_epithelium0.88939722
152MP0000750_abnormal_muscle_regeneration0.87725337
153MP0001915_intracranial_hemorrhage0.86991874
154MP0000343_altered_response_to0.86172962
155MP0009840_abnormal_foam_cell0.85821831
156MP0009672_abnormal_birth_weight0.85288893
157MP0001845_abnormal_inflammatory_respons0.85233841
158MP0000049_abnormal_middle_ear0.84393315
159MP0005058_abnormal_lysosome_morphology0.84021893
160MP0004036_abnormal_muscle_relaxation0.83739408
161MP0001529_abnormal_vocalization0.83371505
162MP0005187_abnormal_penis_morphology0.83020963
163MP0002822_catalepsy0.82835311
164MP0010352_gastrointestinal_tract_polyps0.82691632
165MP0003566_abnormal_cell_adhesion0.82554364
166MP0002114_abnormal_axial_skeleton0.80958016
167MP0006138_congestive_heart_failure0.80858283
168MP0005623_abnormal_meninges_morphology0.80314270
169MP0005620_abnormal_muscle_contractility0.80263416
170MP0003385_abnormal_body_wall0.79850997
171MP0002277_abnormal_respiratory_mucosa0.79526304
172MP0008260_abnormal_autophagy0.78690684
173MP0008469_abnormal_protein_level0.77377604
174MP0003866_abnormal_defecation0.76708341
175MP0009115_abnormal_fat_cell0.75971658
176MP0004858_abnormal_nervous_system0.75761425
177MP0006036_abnormal_mitochondrial_physio0.74646245
178MP0002998_abnormal_bone_remodeling0.74539168
179MP0001986_abnormal_taste_sensitivity0.73539422
180MP0010155_abnormal_intestine_physiology0.73538752
181MP0010630_abnormal_cardiac_muscle0.73256334
182MP0002972_abnormal_cardiac_muscle0.71720257
183MP0009931_abnormal_skin_appearance0.70458035
184MP0005310_abnormal_salivary_gland0.69140748
185MP0004808_abnormal_hematopoietic_stem0.69088969
186MP0002396_abnormal_hematopoietic_system0.67591225
187MP0008874_decreased_physiological_sensi0.67170313
188MP0000465_gastrointestinal_hemorrhage0.67040569
189MP0002254_reproductive_system_inflammat0.66775757

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)9.18220606
2Hypochromic microcytic anemia (HP:0004840)8.45848232
3Poikilocytosis (HP:0004447)6.04804757
4Microcytic anemia (HP:0001935)5.88634162
5Hypochromic anemia (HP:0001931)5.85591074
6Abnormal hemoglobin (HP:0011902)4.56499973
7Eczematoid dermatitis (HP:0000976)4.27719238
8Reticulocytosis (HP:0001923)4.05958488
9Gastrointestinal infarctions (HP:0005244)3.93612087
10Muscle fiber inclusion bodies (HP:0100299)3.91802531
11Polycythemia (HP:0001901)3.89876168
12Paralysis (HP:0003470)3.86444028
13Nemaline bodies (HP:0003798)3.80034366
14Cholelithiasis (HP:0001081)3.71600732
15Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.71041186
16Breast hypoplasia (HP:0003187)3.63964913
17Recurrent abscess formation (HP:0002722)3.59189111
18Myositis (HP:0100614)3.59137317
19Exercise-induced myalgia (HP:0003738)3.53543009
20Type 1 muscle fiber predominance (HP:0003803)3.52196556
21Increased connective tissue (HP:0009025)3.52145945
22Shallow orbits (HP:0000586)3.43083236
23Recurrent bacterial skin infections (HP:0005406)3.41073682
24Abnormality of the labia minora (HP:0012880)3.39972643
25Toxemia of pregnancy (HP:0100603)3.38982156
26Orchitis (HP:0100796)3.34186158
27Abnormal gallbladder morphology (HP:0012437)3.31357116
28Myopathic facies (HP:0002058)3.23544702
29Abnormality of macrophages (HP:0004311)3.23022819
30Male infertility (HP:0003251)3.22603723
31Shawl scrotum (HP:0000049)3.11168907
32Patellar aplasia (HP:0006443)3.10340518
33Prolonged bleeding time (HP:0003010)3.07997426
34Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.07967209
35Short 4th metacarpal (HP:0010044)3.07967209
36Ankle contracture (HP:0006466)3.07447261
37Abnormality of skeletal muscle fiber size (HP:0012084)3.05926381
38Increased variability in muscle fiber diameter (HP:0003557)3.00662109
39Retrobulbar optic neuritis (HP:0100654)2.96521411
40Optic neuritis (HP:0100653)2.96521411
41Cerebral hypomyelination (HP:0006808)2.93646037
42Stomatitis (HP:0010280)2.92313592
43Aplasia/Hypoplasia of the patella (HP:0006498)2.90812665
44Pustule (HP:0200039)2.86824517
45Spontaneous hematomas (HP:0007420)2.79125759
46Facial hemangioma (HP:0000329)2.78455302
47Cortical dysplasia (HP:0002539)2.76921218
48Hyporeflexia of lower limbs (HP:0002600)2.74643793
49Recurrent gram-negative bacterial infections (HP:0005420)2.74275969
50Premature ovarian failure (HP:0008209)2.71877268
51Abnormal delayed hypersensitivity skin test (HP:0002963)2.71694068
52Diaphragmatic weakness (HP:0009113)2.70580969
53Abnormality of iron homeostasis (HP:0011031)2.69952949
54Urticaria (HP:0001025)2.67244140
55Keratoconjunctivitis sicca (HP:0001097)2.61284331
56Abnormality of the fingertips (HP:0001211)2.58406739
57Wrist flexion contracture (HP:0001239)2.57488804
58Increased IgE level (HP:0003212)2.55386035
59Abnormality of the 4th metacarpal (HP:0010012)2.54895204
60Keratoconjunctivitis (HP:0001096)2.53172397
61Oligodactyly (HP:0012165)2.52163148
62Ulnar deviation of the wrist (HP:0003049)2.50616115
63Gingivitis (HP:0000230)2.48593609
64Elevated erythrocyte sedimentation rate (HP:0003565)2.47012407
65Premature rupture of membranes (HP:0001788)2.43665293
66Absent radius (HP:0003974)2.41561600
67Secondary amenorrhea (HP:0000869)2.39272394
68Overlapping toe (HP:0001845)2.38238545
69Chronic obstructive pulmonary disease (HP:0006510)2.37955925
70Obstructive lung disease (HP:0006536)2.37955925
71Recurrent skin infections (HP:0001581)2.37923463
72Ileus (HP:0002595)2.37635955
73Acanthocytosis (HP:0001927)2.37453216
74Ependymoma (HP:0002888)2.36432283
75EMG: myopathic abnormalities (HP:0003458)2.36050905
76Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.35435118
77Aplasia involving forearm bones (HP:0009822)2.35423784
78Absent forearm bone (HP:0003953)2.35423784
79Abnormality of the gallbladder (HP:0005264)2.34646667
80Recurrent fungal infections (HP:0002841)2.33775463
81Impulsivity (HP:0100710)2.32427219
82Round ear (HP:0100830)2.31575900
83Adrenal hypoplasia (HP:0000835)2.31032981
84Increased serum ferritin (HP:0003281)2.29619416
85Aplasia/Hypoplasia of the sternum (HP:0006714)2.28944757
86Birth length less than 3rd percentile (HP:0003561)2.28002189
87Peritonitis (HP:0002586)2.27786376
88Asymmetric septal hypertrophy (HP:0001670)2.27039232
89Abnormality of transition element cation homeostasis (HP:0011030)2.25684852
90Cellulitis (HP:0100658)2.21143989
91Vasculitis (HP:0002633)2.20916544
92Osteomalacia (HP:0002749)2.20861145
93Osteomyelitis (HP:0002754)2.20067276
94Selective tooth agenesis (HP:0001592)2.20018616
95Recurrent cutaneous fungal infections (HP:0011370)2.19687912
96Chronic mucocutaneous candidiasis (HP:0002728)2.19687912
97Protrusio acetabuli (HP:0003179)2.19079997
98Chest pain (HP:0100749)2.18498411
99Nasal polyposis (HP:0100582)2.16047848
100Neoplasm of the oral cavity (HP:0100649)2.14677266
101Abnormality of the aortic arch (HP:0012303)2.14593174
102Encephalitis (HP:0002383)2.14351666
103Meningitis (HP:0001287)2.13822130
104Bicornuate uterus (HP:0000813)2.13817923
105Exercise-induced muscle cramps (HP:0003710)2.13114022
106Centrally nucleated skeletal muscle fibers (HP:0003687)2.12417160
107Abnormality of reticulocytes (HP:0004312)2.12336637
108Abnormality of the astrocytes (HP:0100707)2.11356162
109Astrocytoma (HP:0009592)2.11356162
110Hypertriglyceridemia (HP:0002155)2.10084160
111Anorexia (HP:0002039)2.08476519
112Abnormality of chromosome segregation (HP:0002916)2.08031702
113EMG: neuropathic changes (HP:0003445)2.07877191
114Carpal bone hypoplasia (HP:0001498)2.07489257
115Trigonocephaly (HP:0000243)2.06776068
116Mediastinal lymphadenopathy (HP:0100721)2.06481122
117Increased nuchal translucency (HP:0010880)2.05696385
118Leukocytosis (HP:0001974)2.04442423
119Distal arthrogryposis (HP:0005684)2.02983915
120Episodic fever (HP:0001954)2.02681876
121Broad alveolar ridges (HP:0000187)2.01191545
122Epistaxis (HP:0000421)2.00129242
123Hyperbilirubinemia (HP:0002904)1.99983409
124Oligodactyly (hands) (HP:0001180)1.98656178
125Muscle fiber splitting (HP:0003555)1.98342863
126Rhabdomyolysis (HP:0003201)1.97820844
127Atresia of the external auditory canal (HP:0000413)1.96505879
128Abnormality of the nasal mucosa (HP:0000433)1.96485461
129Distal lower limb muscle weakness (HP:0009053)1.96378692
130Esophageal atresia (HP:0002032)1.95191855
131Ectopic kidney (HP:0000086)1.95021274
132Muscle hypertrophy of the lower extremities (HP:0008968)1.93960897
133Rib fusion (HP:0000902)1.93337238
134Easy fatigability (HP:0003388)1.92259867
135Aplasia/hypoplasia of the humerus (HP:0006507)1.92229140
136Absent hand (HP:0004050)1.92148885
137High anterior hairline (HP:0009890)1.90650304
138Acne (HP:0001061)1.90173734
139Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.89603432
140Aplasia/Hypoplasia of the breasts (HP:0010311)1.89372704
141Short humerus (HP:0005792)1.89327092
142Slender build (HP:0001533)1.89247055
143Hematochezia (HP:0002573)1.89218361
144Renal duplication (HP:0000075)1.88818213
145Metaphyseal cupping (HP:0003021)1.88118366
146Medulloblastoma (HP:0002885)1.85174261
147Subaortic stenosis (HP:0001682)1.85170082
148Abnormality of the left ventricular outflow tract (HP:0011103)1.85170082
149Neoplasm of striated muscle (HP:0009728)1.84738670
150Aortic dissection (HP:0002647)1.83871082
151Increased IgM level (HP:0003496)1.83346205
152Overriding aorta (HP:0002623)1.82936571
153Pulmonary infiltrates (HP:0002113)1.82185714
154Obstructive sleep apnea (HP:0002870)1.81711946
155Heterotopia (HP:0002282)1.80262492
156Breast aplasia (HP:0100783)1.80109333
157Hypercortisolism (HP:0001578)1.79179908
158Deviation of the thumb (HP:0009603)1.78759203
159Hypoplastic labia majora (HP:0000059)1.78023262
160Coronal craniosynostosis (HP:0004440)1.77585131
161Proximal placement of thumb (HP:0009623)1.75877798
162Difficulty running (HP:0009046)1.75468686
163Papillary thyroid carcinoma (HP:0002895)1.74898597
164Midline defect of the nose (HP:0004122)1.71552456
165Soft skin (HP:0000977)1.71361406
166Abnormality of the distal phalanx of the thumb (HP:0009617)1.71110249
167Sparse lateral eyebrow (HP:0005338)1.70787851
168Adactyly (HP:0009776)1.70621327
169Abnormality of the labia majora (HP:0012881)1.70386739
170Abnormality of the ileum (HP:0001549)1.68810175
171Glioma (HP:0009733)1.68489385
172Short phalanx of the thumb (HP:0009660)1.68182368
173Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.67964993
174Deviation of the hallux (HP:0010051)1.67271834
175Hallux valgus (HP:0001822)1.66950696
176Abnormality of the diencephalon (HP:0010662)1.65076273
177Skull defect (HP:0001362)1.64801413
178Preaxial foot polydactyly (HP:0001841)1.64494262
179Abnormality of the carotid arteries (HP:0005344)1.63341502
180Broad toe (HP:0001837)1.62715655
181Hemivertebrae (HP:0002937)1.62021902
182Supernumerary spleens (HP:0009799)1.61972274
183Aplasia/Hypoplasia of the uvula (HP:0010293)1.61504499
184Meckel diverticulum (HP:0002245)1.61255379
185Small intestinal stenosis (HP:0012848)1.60914784
186Duodenal stenosis (HP:0100867)1.60914784
187Genu recurvatum (HP:0002816)1.60746384
188Aplasia/Hypoplasia involving the musculature (HP:0001460)1.60156253
189Chromsome breakage (HP:0040012)1.60081607
190Cerebral aneurysm (HP:0004944)1.59738412
191Spina bifida occulta (HP:0003298)1.59506430
192Bladder diverticulum (HP:0000015)1.59242744
193Broad hallux (HP:0010055)1.58582833
194Short 1st metacarpal (HP:0010034)1.57252526
195Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.57252526
196Megalocornea (HP:0000485)1.56497404
197Malignant gastrointestinal tract tumors (HP:0006749)1.54422861
198Gastrointestinal carcinoma (HP:0002672)1.54422861

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP2K34.16753437
2LATS13.26717565
3TYRO33.15246575
4PRPF4B3.13253845
5TAOK23.09083322
6CDK122.97958806
7RIPK42.72754508
8TRIB32.62881215
9MAP3K112.58997880
10TTK2.58385435
11MAP3K32.54483495
12LATS22.47830751
13ERN12.47146457
14EEF2K2.38952624
15NEK22.33862647
16GRK62.25627545
17CDC72.16351778
18OBSCN2.08372374
19TESK22.04537445
20BUB11.99256519
21FGFR21.98011593
22TNK21.97839799
23MAP3K101.95889553
24MAP4K11.91779063
25ICK1.90049202
26PLK41.89555975
27STK38L1.71174692
28CHEK21.69530312
29PDGFRA1.66189157
30IRAK41.65757391
31TTN1.65246940
32STK101.62862915
33STK31.61388360
34DYRK21.59581959
35BRD41.58669050
36MELK1.58475650
37ZAP701.57906822
38MAP3K11.57347099
39PRKD31.55997645
40FES1.54268927
41CSK1.53544625
42TYK21.52100859
43EPHB21.48438818
44PLK11.43546843
45MARK21.41962359
46CDK71.40859609
47BLK1.38325305
48MAP3K71.34860219
49MTOR1.28090459
50BMX1.27127353
51MAP3K131.26771054
52PASK1.25896720
53DYRK31.22344733
54MAPK121.21739872
55LIMK11.21357251
56IKBKE1.18869900
57KSR11.17341247
58SGK31.17002408
59HIPK21.16373482
60WNK11.16289820
61MARK31.14311333
62MAP3K81.12977904
63EPHA31.12930395
64HCK1.12153431
65TBK11.11470238
66WEE11.10075348
67SMG11.08982056
68SIK21.08943076
69PIM11.06067602
70CHEK11.05000964
71MAP3K61.04208910
72NEK11.04074312
73SIK31.03922957
74EPHB11.00424763
75MAP2K41.00231311
76BCR0.99907787
77AURKA0.99539982
78SYK0.98272295
79PAK40.98201461
80MAPKAPK30.98102753
81JAK20.97683293
82PRKAA20.96861781
83RPS6KC10.95860763
84RPS6KL10.95860763
85DMPK0.95383447
86FGR0.95235322
87KSR20.95039200
88PTK2B0.94365090
89BTK0.94255769
90STK110.93835368
91AURKB0.93608440
92EIF2AK10.93541002
93MAP3K50.93428115
94EPHA20.93372701
95SGK20.92635695
96CDK90.92277273
97BRAF0.92221603
98JAK30.91843147
99ERBB40.91372336
100TAOK10.90570122
101DDR20.85350497
102STK380.84530810
103RPS6KA60.83969134
104CDK40.83724253
105STK40.82878263
106PDK40.82755006
107PDK30.82755006
108PHKG20.82014207
109PHKG10.82014207
110PKN20.81592226
111RPS6KA20.81163058
112SRPK10.79024697
113DYRK1B0.77303253
114PIK3CG0.76867087
115TESK10.75643076
116MAP2K60.75507823
117PLK30.74602282
118PTK60.74123645
119IKBKB0.73147872
120NTRK20.72539405
121PINK10.72468532
122CSNK1A1L0.72265335
123BRSK10.70845185
124LYN0.69952982
125CAMK40.69308707
126CSNK1G10.69223112
127FGFR40.69124254
128RPS6KA40.68160579
129BRSK20.66025863
130RPS6KB20.65994822
131PDPK10.65871855
132TAOK30.65418074
133PRKAA10.64909126
134CDK20.63660495
135TXK0.62639222
136PRKD20.62636956
137MET0.62433036
138ATR0.62291008
139FGFR10.62185920
140CSNK1G30.62080754
141SGK2230.61793469
142SGK4940.61793469
143MAP2K10.61115891
144YES10.59722395
145MAPK70.59647863
146PAK10.59310741
147SIK10.58194929
148PDGFRB0.57948603
149CDK10.57925184
150ATM0.57763157
151PTK20.56780300
152TLK10.56712309
153CDK60.53647771
154LRRK20.53194780
155CAMK1G0.52469484
156PDK10.51165121
157TRPM70.49617029
158MKNK10.49333135
159CSNK1D0.48312487
160TGFBR20.48007542
161PAK60.47402445
162MAP2K20.46721702
163RET0.46710404
164LCK0.46442552
165IRAK20.44894113
166MARK10.44729858
167CHUK0.44541824
168CAMK10.44532792
169CDC42BPA0.44304412
170ERBB20.43908927
171MAP3K140.43660596
172DAPK20.42681501
173PRKCZ0.42212264
174SGK10.41720917
175ROCK20.41497131
176STK390.41030850
177ACVR1B0.39211114
178RPS6KA50.37728620
179PRKCI0.37609562
180PDK20.37405507
181PAK20.37285396
182CAMK1D0.37234663

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041103.31486056
2Malaria_Homo sapiens_hsa051442.91376897
3Vitamin B6 metabolism_Homo sapiens_hsa007502.85764973
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.69543599
5Osteoclast differentiation_Homo sapiens_hsa043802.53837721
6RNA transport_Homo sapiens_hsa030132.47180605
7Acute myeloid leukemia_Homo sapiens_hsa052212.21613415
8Basal transcription factors_Homo sapiens_hsa030222.14698597
9Hippo signaling pathway_Homo sapiens_hsa043902.05112142
10p53 signaling pathway_Homo sapiens_hsa041152.03730986
11Basal cell carcinoma_Homo sapiens_hsa052172.01082106
12DNA replication_Homo sapiens_hsa030301.96976201
13MicroRNAs in cancer_Homo sapiens_hsa052061.91017936
14Notch signaling pathway_Homo sapiens_hsa043301.89301783
15Mismatch repair_Homo sapiens_hsa034301.84610805
16RNA polymerase_Homo sapiens_hsa030201.84559934
17Spliceosome_Homo sapiens_hsa030401.82836182
18Base excision repair_Homo sapiens_hsa034101.79471773
19mRNA surveillance pathway_Homo sapiens_hsa030151.77572921
20Leishmaniasis_Homo sapiens_hsa051401.76522017
21B cell receptor signaling pathway_Homo sapiens_hsa046621.75795542
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.74737844
23Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.69985607
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.69203898
25Hedgehog signaling pathway_Homo sapiens_hsa043401.68344927
26Homologous recombination_Homo sapiens_hsa034401.68056585
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.65310025
28TGF-beta signaling pathway_Homo sapiens_hsa043501.63234431
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.61269266
30Adipocytokine signaling pathway_Homo sapiens_hsa049201.61069349
31Tuberculosis_Homo sapiens_hsa051521.60388196
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.56020475
33Fanconi anemia pathway_Homo sapiens_hsa034601.55687894
34Renal cell carcinoma_Homo sapiens_hsa052111.55447318
35Pancreatic cancer_Homo sapiens_hsa052121.51276814
36Staphylococcus aureus infection_Homo sapiens_hsa051501.50721796
37African trypanosomiasis_Homo sapiens_hsa051431.47208683
38Adherens junction_Homo sapiens_hsa045201.47013507
39Small cell lung cancer_Homo sapiens_hsa052221.46880142
40Dorso-ventral axis formation_Homo sapiens_hsa043201.46128612
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.43137207
42Oocyte meiosis_Homo sapiens_hsa041141.41148228
43RNA degradation_Homo sapiens_hsa030181.40970161
44Nucleotide excision repair_Homo sapiens_hsa034201.40512930
45Colorectal cancer_Homo sapiens_hsa052101.40234951
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.39843337
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.35555272
48Non-homologous end-joining_Homo sapiens_hsa034501.34171316
49Chronic myeloid leukemia_Homo sapiens_hsa052201.32652931
50Chemokine signaling pathway_Homo sapiens_hsa040621.31028410
51T cell receptor signaling pathway_Homo sapiens_hsa046601.30148559
52mTOR signaling pathway_Homo sapiens_hsa041501.26579199
53Endometrial cancer_Homo sapiens_hsa052131.26253352
54Insulin signaling pathway_Homo sapiens_hsa049101.26072262
55NOD-like receptor signaling pathway_Homo sapiens_hsa046211.22985491
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.22914229
57Measles_Homo sapiens_hsa051621.22913041
58Insulin resistance_Homo sapiens_hsa049311.21222787
59Lysine degradation_Homo sapiens_hsa003101.19302693
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.18392383
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.18312394
62Steroid biosynthesis_Homo sapiens_hsa001001.17969820
63Hepatitis C_Homo sapiens_hsa051601.17624283
64Toxoplasmosis_Homo sapiens_hsa051451.16816780
65Prostate cancer_Homo sapiens_hsa052151.14604508
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.13672569
67Bladder cancer_Homo sapiens_hsa052191.13512023
68Hematopoietic cell lineage_Homo sapiens_hsa046401.12074019
69Neurotrophin signaling pathway_Homo sapiens_hsa047221.11174674
70Tight junction_Homo sapiens_hsa045301.10643584
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.09643190
72Influenza A_Homo sapiens_hsa051641.08705986
73TNF signaling pathway_Homo sapiens_hsa046681.06712365
74Non-small cell lung cancer_Homo sapiens_hsa052231.06579566
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05775532
76Hepatitis B_Homo sapiens_hsa051611.05453501
77Collecting duct acid secretion_Homo sapiens_hsa049661.04596971
78Leukocyte transendothelial migration_Homo sapiens_hsa046701.03131287
79Prolactin signaling pathway_Homo sapiens_hsa049171.02851702
80Linoleic acid metabolism_Homo sapiens_hsa005910.98445197
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.98234664
82Apoptosis_Homo sapiens_hsa042100.98032963
83Inositol phosphate metabolism_Homo sapiens_hsa005620.96116665
84GnRH signaling pathway_Homo sapiens_hsa049120.95096919
85Phagosome_Homo sapiens_hsa041450.94503694
86Viral carcinogenesis_Homo sapiens_hsa052030.94223702
87Ether lipid metabolism_Homo sapiens_hsa005650.93842148
88Proteoglycans in cancer_Homo sapiens_hsa052050.92682577
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91869169
90Platelet activation_Homo sapiens_hsa046110.91319504
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91224030
92HTLV-I infection_Homo sapiens_hsa051660.91106804
93Pathways in cancer_Homo sapiens_hsa052000.90728696
94Herpes simplex infection_Homo sapiens_hsa051680.88734855
95NF-kappa B signaling pathway_Homo sapiens_hsa040640.88282060
96MAPK signaling pathway_Homo sapiens_hsa040100.87902069
97RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.87103765
98Wnt signaling pathway_Homo sapiens_hsa043100.86568844
99AMPK signaling pathway_Homo sapiens_hsa041520.86514892
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85751670
101Axon guidance_Homo sapiens_hsa043600.85610439
102Focal adhesion_Homo sapiens_hsa045100.84395044
103Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.83955293
104Choline metabolism in cancer_Homo sapiens_hsa052310.83517743
105ECM-receptor interaction_Homo sapiens_hsa045120.83072028
106Ovarian steroidogenesis_Homo sapiens_hsa049130.82604987
107VEGF signaling pathway_Homo sapiens_hsa043700.80821565
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79372795
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79197896
110Type II diabetes mellitus_Homo sapiens_hsa049300.78605264
111Epstein-Barr virus infection_Homo sapiens_hsa051690.77850270
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77254855
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77169355
114Pyrimidine metabolism_Homo sapiens_hsa002400.75097540
115Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74900626
116Primary immunodeficiency_Homo sapiens_hsa053400.74662636
117Graft-versus-host disease_Homo sapiens_hsa053320.73821937
118FoxO signaling pathway_Homo sapiens_hsa040680.72172853
119Viral myocarditis_Homo sapiens_hsa054160.69718343
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.69087363
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68360988
122Melanoma_Homo sapiens_hsa052180.68074102
123Amoebiasis_Homo sapiens_hsa051460.67838983
124Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67290867
125Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66572692
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66081314
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64903197
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64688158
129PI3K-Akt signaling pathway_Homo sapiens_hsa041510.60358852
130Glioma_Homo sapiens_hsa052140.60077218
131One carbon pool by folate_Homo sapiens_hsa006700.59489686
132Circadian rhythm_Homo sapiens_hsa047100.58568765
133Legionellosis_Homo sapiens_hsa051340.58470509
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.58366329
135Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58278734
136Autoimmune thyroid disease_Homo sapiens_hsa053200.58024562
137Endocytosis_Homo sapiens_hsa041440.57229755
138Central carbon metabolism in cancer_Homo sapiens_hsa052300.57153948
139Allograft rejection_Homo sapiens_hsa053300.56203138
140Other glycan degradation_Homo sapiens_hsa005110.54662599
141Systemic lupus erythematosus_Homo sapiens_hsa053220.54600814
142Biosynthesis of amino acids_Homo sapiens_hsa012300.53997163
143Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53870571
144Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.52582337
145Regulation of autophagy_Homo sapiens_hsa041400.51374493
146Fatty acid biosynthesis_Homo sapiens_hsa000610.51054534
147Thyroid cancer_Homo sapiens_hsa052160.50807425
148Long-term potentiation_Homo sapiens_hsa047200.50319625
149Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50194476
150Rap1 signaling pathway_Homo sapiens_hsa040150.50186742
151Phospholipase D signaling pathway_Homo sapiens_hsa040720.49798226
152SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48434011
153Glycerolipid metabolism_Homo sapiens_hsa005610.48299734
154Lysosome_Homo sapiens_hsa041420.47809981
155Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46838214
156Glucagon signaling pathway_Homo sapiens_hsa049220.46767094
157Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45393295
158Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44876801
1592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44224067
160HIF-1 signaling pathway_Homo sapiens_hsa040660.43512181
161ErbB signaling pathway_Homo sapiens_hsa040120.42748515
162Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42099509
163Cysteine and methionine metabolism_Homo sapiens_hsa002700.41369927
164Pentose phosphate pathway_Homo sapiens_hsa000300.39790400
165Purine metabolism_Homo sapiens_hsa002300.39519703
166AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39416601
167Arginine and proline metabolism_Homo sapiens_hsa003300.38700176
168Shigellosis_Homo sapiens_hsa051310.38655980

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