NAT16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.30347890
2nucleobase catabolic process (GO:0046113)4.19725230
3pyrimidine nucleobase catabolic process (GO:0006208)4.14806363
4neuron cell-cell adhesion (GO:0007158)3.85696719
5glycerophospholipid catabolic process (GO:0046475)3.62546419
6cellular ketone body metabolic process (GO:0046950)3.60173371
7postsynaptic membrane organization (GO:0001941)3.56658351
8proline transport (GO:0015824)3.50296162
9regulation of neurotransmitter uptake (GO:0051580)3.37351521
10behavioral response to ethanol (GO:0048149)3.36209178
11neuronal action potential propagation (GO:0019227)3.33693192
12dendritic spine morphogenesis (GO:0060997)3.33688493
13regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.27695686
14nonmotile primary cilium assembly (GO:0035058)3.25773698
15regulation of action potential (GO:0098900)3.23138416
16platelet dense granule organization (GO:0060155)3.21366941
17presynaptic membrane assembly (GO:0097105)3.20302145
18ketone body metabolic process (GO:1902224)3.20013192
19positive regulation of action potential (GO:0045760)3.19734403
20piRNA metabolic process (GO:0034587)3.19317820
21inositol phosphate catabolic process (GO:0071545)3.17847542
22response to pheromone (GO:0019236)3.16997860
23presynaptic membrane organization (GO:0097090)3.10943887
24positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.03761977
25gamma-aminobutyric acid transport (GO:0015812)3.02353149
26positive regulation of mitochondrial fission (GO:0090141)2.97965842
27startle response (GO:0001964)2.93881646
28epithelial cilium movement (GO:0003351)2.93687635
29anterograde synaptic vesicle transport (GO:0048490)2.92784034
30epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.92090295
31protein K11-linked deubiquitination (GO:0035871)2.89291237
32protein localization to cilium (GO:0061512)2.87185369
33negative regulation of cytosolic calcium ion concentration (GO:0051481)2.87173578
34preassembly of GPI anchor in ER membrane (GO:0016254)2.86521519
35negative regulation of synaptic transmission, GABAergic (GO:0032229)2.86254278
36regulation of short-term neuronal synaptic plasticity (GO:0048172)2.85971161
37neural tube formation (GO:0001841)2.85358832
38water-soluble vitamin biosynthetic process (GO:0042364)2.83334368
39inositol phosphate dephosphorylation (GO:0046855)2.77671101
40phosphorylated carbohydrate dephosphorylation (GO:0046838)2.77671101
41auditory behavior (GO:0031223)2.77183389
42protein localization to synapse (GO:0035418)2.75574559
43synaptic vesicle maturation (GO:0016188)2.74536305
44synapse assembly (GO:0007416)2.73699384
45protein-cofactor linkage (GO:0018065)2.73566552
46axoneme assembly (GO:0035082)2.70918939
47regulation of glucokinase activity (GO:0033131)2.68646171
48regulation of hexokinase activity (GO:1903299)2.68646171
49protein complex biogenesis (GO:0070271)2.68642208
50regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.67426530
51regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.67426530
52L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.65341667
53ionotropic glutamate receptor signaling pathway (GO:0035235)2.63694468
54retinal cone cell development (GO:0046549)2.63039690
55calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.62717270
56membrane depolarization during action potential (GO:0086010)2.62714202
57regulation of telomere maintenance (GO:0032204)2.60354085
58synaptic transmission, glutamatergic (GO:0035249)2.59954732
59establishment of protein localization to Golgi (GO:0072600)2.59898267
60negative regulation of heart rate (GO:0010459)2.59206322
61DNA methylation involved in gamete generation (GO:0043046)2.57600791
62detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.56789311
63C-terminal protein amino acid modification (GO:0018410)2.56764772
64C-terminal protein lipidation (GO:0006501)2.56022635
65NADH dehydrogenase complex assembly (GO:0010257)2.55531496
66mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.55531496
67mitochondrial respiratory chain complex I assembly (GO:0032981)2.55531496
68detection of light stimulus involved in sensory perception (GO:0050962)2.55443106
69detection of light stimulus involved in visual perception (GO:0050908)2.55443106
70respiratory chain complex IV assembly (GO:0008535)2.54851400
71synaptic transmission, cholinergic (GO:0007271)2.53448688
72reflex (GO:0060004)2.52134552
73neuronal action potential (GO:0019228)2.51701057
74glycosphingolipid biosynthetic process (GO:0006688)2.51114047
75glutamate receptor signaling pathway (GO:0007215)2.50862299
76kidney morphogenesis (GO:0060993)2.50075227
77protein polyglutamylation (GO:0018095)2.49763243
78cilium organization (GO:0044782)2.48036355
79cilium assembly (GO:0042384)2.46538525
80serotonin metabolic process (GO:0042428)2.46135491
81axonal fasciculation (GO:0007413)2.45276648
82dopamine transport (GO:0015872)2.44465250
83endocrine pancreas development (GO:0031018)2.44245852
84G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.43735724
85indolalkylamine metabolic process (GO:0006586)2.43162816
86polyol catabolic process (GO:0046174)2.42966825
87positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.42737651
88L-fucose catabolic process (GO:0042355)2.42237294
89fucose catabolic process (GO:0019317)2.42237294
90L-fucose metabolic process (GO:0042354)2.42237294
91cilium morphogenesis (GO:0060271)2.41999890
92negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.41083430
93negative regulation of translation, ncRNA-mediated (GO:0040033)2.41083430
94regulation of translation, ncRNA-mediated (GO:0045974)2.41083430
95protein targeting to Golgi (GO:0000042)2.39383149
96anterograde axon cargo transport (GO:0008089)2.38945255
97mitochondrial respiratory chain complex assembly (GO:0033108)2.38452744
98primary amino compound metabolic process (GO:1901160)2.38155031
99negative regulation of telomere maintenance (GO:0032205)2.37526877
100peptidyl-histidine modification (GO:0018202)2.36868697

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.64133746
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.35394913
3GBX2_23144817_ChIP-Seq_PC3_Human3.01519467
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.72551285
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.71196056
6IGF1R_20145208_ChIP-Seq_DFB_Human2.69913579
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.56034754
8EZH2_22144423_ChIP-Seq_EOC_Human2.47440638
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.42494698
10FUS_26573619_Chip-Seq_HEK293_Human2.40576233
11VDR_22108803_ChIP-Seq_LS180_Human2.36230362
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.31499549
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06189535
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.99790554
15REST_21632747_ChIP-Seq_MESCs_Mouse1.99568010
16TAF15_26573619_Chip-Seq_HEK293_Human1.94590501
17P300_19829295_ChIP-Seq_ESCs_Human1.89915217
18EWS_26573619_Chip-Seq_HEK293_Human1.76838231
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73192287
20REST_18959480_ChIP-ChIP_MESCs_Mouse1.68005387
21SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66918584
22SALL1_21062744_ChIP-ChIP_HESCs_Human1.66871673
23ER_23166858_ChIP-Seq_MCF-7_Human1.66446312
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.64000402
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61956655
26SMAD4_21799915_ChIP-Seq_A2780_Human1.61881779
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.59767731
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.58209391
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58123364
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.55487687
31STAT3_23295773_ChIP-Seq_U87_Human1.55440192
32AR_25329375_ChIP-Seq_VCAP_Human1.55426923
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.55422541
34BCAT_22108803_ChIP-Seq_LS180_Human1.55066783
35SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52328859
36TP53_22573176_ChIP-Seq_HFKS_Human1.49718217
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47440462
38CBP_20019798_ChIP-Seq_JUKART_Human1.45925067
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45925067
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.45574818
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44430077
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.43859023
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43564696
44SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.42627267
45TCF4_23295773_ChIP-Seq_U87_Human1.39122826
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.38700584
47MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33879498
48E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.33813478
49EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.33151198
50RNF2_27304074_Chip-Seq_NSC_Mouse1.32933346
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32811556
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.31143778
53NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31120580
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29814208
55GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28300534
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.28183217
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27031806
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27031806
59KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26216071
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24460389
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22957572
62TCF4_22108803_ChIP-Seq_LS180_Human1.21645789
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21401740
64EED_16625203_ChIP-ChIP_MESCs_Mouse1.17619488
65NANOG_18555785_Chip-Seq_ESCs_Mouse1.16823609
66JARID2_20064375_ChIP-Seq_MESCs_Mouse1.16162733
67RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15188622
68FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.14930647
69RUNX2_22187159_ChIP-Seq_PCA_Human1.14783252
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14207148
71KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.13835341
72ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.13817397
73EZH2_27304074_Chip-Seq_ESCs_Mouse1.13459043
74GABP_17652178_ChIP-ChIP_JURKAT_Human1.13404127
75HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.12983765
76NANOG_19829295_ChIP-Seq_ESCs_Human1.12606869
77SOX2_19829295_ChIP-Seq_ESCs_Human1.12606869
78TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11851078
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11490665
80SMAD4_21741376_ChIP-Seq_EPCs_Human1.10830872
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10815577
82FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08567951
83FOXA1_25329375_ChIP-Seq_VCAP_Human1.08567951
84FLI1_21867929_ChIP-Seq_TH2_Mouse1.08365776
85ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07002290
86RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06664426
87NCOR_22424771_ChIP-Seq_293T_Human1.06212270
88EZH2_27294783_Chip-Seq_NPCs_Mouse1.05580302
89EZH2_27294783_Chip-Seq_ESCs_Mouse1.04765480
90SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04165604
91SOX2_21211035_ChIP-Seq_LN229_Gbm1.03939103
92SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.02924348
93AR_21572438_ChIP-Seq_LNCaP_Human1.01859923
94P53_22387025_ChIP-Seq_ESCs_Mouse1.01575911
95GATA3_21878914_ChIP-Seq_MCF-7_Human1.01365611
96MYC_18940864_ChIP-ChIP_HL60_Human1.00129475
97SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.99781805
98TAL1_26923725_Chip-Seq_HPCs_Mouse0.99588885
99SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.99351006
100KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98583020

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.37752280
2MP0003787_abnormal_imprinting3.32948471
3MP0001968_abnormal_touch/_nociception2.75597197
4MP0002837_dystrophic_cardiac_calcinosis2.52929893
5MP0003122_maternal_imprinting2.45124191
6MP0002736_abnormal_nociception_after2.43226629
7MP0005645_abnormal_hypothalamus_physiol2.42647102
8MP0009046_muscle_twitch2.42288596
9MP0004270_analgesia2.31134032
10MP0001984_abnormal_olfaction2.18132938
11MP0009745_abnormal_behavioral_response2.16238465
12MP0004859_abnormal_synaptic_plasticity2.13625717
13MP0002638_abnormal_pupillary_reflex2.13376780
14MP0006072_abnormal_retinal_apoptosis2.09855299
15MP0003121_genomic_imprinting2.07540160
16MP0002909_abnormal_adrenal_gland2.07199264
17MP0002272_abnormal_nervous_system2.04424992
18MP0003195_calcinosis2.03186413
19MP0005551_abnormal_eye_electrophysiolog2.02532273
20MP0003635_abnormal_synaptic_transmissio1.89000283
21MP0003880_abnormal_central_pattern1.84568401
22MP0001501_abnormal_sleep_pattern1.81735939
23MP0001986_abnormal_taste_sensitivity1.81402647
24MP0005253_abnormal_eye_physiology1.80794052
25MP0006276_abnormal_autonomic_nervous1.80084327
26MP0005379_endocrine/exocrine_gland_phen1.79625030
27MP0002102_abnormal_ear_morphology1.79564084
28MP0002572_abnormal_emotion/affect_behav1.77476168
29MP0004885_abnormal_endolymph1.77469926
30MP0010386_abnormal_urinary_bladder1.76109789
31MP0001529_abnormal_vocalization1.72896679
32MP0002734_abnormal_mechanical_nocicepti1.71973213
33MP0002557_abnormal_social/conspecific_i1.71455156
34MP0005646_abnormal_pituitary_gland1.65647217
35MP0002063_abnormal_learning/memory/cond1.65397758
36MP0004142_abnormal_muscle_tone1.62533859
37MP0002876_abnormal_thyroid_physiology1.61380069
38MP0002064_seizures1.61348635
39MP0001486_abnormal_startle_reflex1.59528732
40MP0002735_abnormal_chemical_nociception1.56364590
41MP0001905_abnormal_dopamine_level1.52163444
42MP0001502_abnormal_circadian_rhythm1.50852290
43MP0005423_abnormal_somatic_nervous1.50562249
44MP0000631_abnormal_neuroendocrine_gland1.50084177
45MP0002733_abnormal_thermal_nociception1.46754867
46MP0001970_abnormal_pain_threshold1.45781560
47MP0000013_abnormal_adipose_tissue1.38927810
48MP0000778_abnormal_nervous_system1.36527443
49MP0002163_abnormal_gland_morphology1.34659083
50MP0005084_abnormal_gallbladder_morpholo1.34308441
51MP0004133_heterotaxia1.34273107
52MP0002928_abnormal_bile_duct1.33233790
53MP0002067_abnormal_sensory_capabilities1.31976357
54MP0004043_abnormal_pH_regulation1.29078594
55MP0003011_delayed_dark_adaptation1.26996630
56MP0005386_behavior/neurological_phenoty1.26465533
57MP0004924_abnormal_behavior1.26465533
58MP0009780_abnormal_chondrocyte_physiolo1.26244033
59MP0001188_hyperpigmentation1.25023694
60MP0002693_abnormal_pancreas_physiology1.21917766
61MP0002184_abnormal_innervation1.21218323
62MP0002229_neurodegeneration1.16789453
63MP0001440_abnormal_grooming_behavior1.15875130
64MP0001944_abnormal_pancreas_morphology1.15284023
65MP0000372_irregular_coat_pigmentation1.07589638
66MP0004742_abnormal_vestibular_system1.06968558
67MP0000427_abnormal_hair_cycle1.05215151
68MP0008872_abnormal_physiological_respon1.05078477
69MP0003646_muscle_fatigue1.03933933
70MP0002882_abnormal_neuron_morphology0.99710945
71MP0004811_abnormal_neuron_physiology0.99388561
72MP0002653_abnormal_ependyma_morphology0.95549766
73MP0004215_abnormal_myocardial_fiber0.92193625
74MP0002751_abnormal_autonomic_nervous0.92076214
75MP0003123_paternal_imprinting0.91148670
76MP0000955_abnormal_spinal_cord0.90163566
77MP0002069_abnormal_eating/drinking_beha0.89456126
78MP0002752_abnormal_somatic_nervous0.88576141
79MP0002938_white_spotting0.88099561
80MP0001485_abnormal_pinna_reflex0.87996361
81MP0008875_abnormal_xenobiotic_pharmacok0.87864458
82MP0004085_abnormal_heartbeat0.87769606
83MP0001919_abnormal_reproductive_system0.87007265
84MP0001764_abnormal_homeostasis0.86984460
85MP0005389_reproductive_system_phenotype0.85950985
86MP0000569_abnormal_digit_pigmentation0.84235997
87MP0004145_abnormal_muscle_electrophysio0.83944208
88MP0000639_abnormal_adrenal_gland0.83350856
89MP0002066_abnormal_motor_capabilities/c0.81111658
90MP0002160_abnormal_reproductive_system0.80784393
91MP0005195_abnormal_posterior_eye0.80608408
92MP0003633_abnormal_nervous_system0.80381667
93MP0008995_early_reproductive_senescence0.80238998
94MP0003698_abnormal_male_reproductive0.80016829
95MP0008789_abnormal_olfactory_epithelium0.79197398
96MP0008058_abnormal_DNA_repair0.78570675
97MP0001756_abnormal_urination0.77263580
98MP0006292_abnormal_olfactory_placode0.76807329
99MP0005448_abnormal_energy_balance0.75904788
100MP0005394_taste/olfaction_phenotype0.74965525

Predicted human phenotypes

RankGene SetZ-score
1Medial flaring of the eyebrow (HP:0010747)3.79292904
2Pancreatic cysts (HP:0001737)3.68462261
3Molar tooth sign on MRI (HP:0002419)3.61156604
4Abnormality of midbrain morphology (HP:0002418)3.61156604
5Hyperventilation (HP:0002883)3.43812967
6Pancreatic fibrosis (HP:0100732)3.39061540
7Nephronophthisis (HP:0000090)3.37755080
8Gait imbalance (HP:0002141)3.32417295
9Limb dystonia (HP:0002451)3.31886552
10True hermaphroditism (HP:0010459)3.23061574
11Congenital stationary night blindness (HP:0007642)3.03988056
12Agitation (HP:0000713)3.02302679
13Type II lissencephaly (HP:0007260)3.01704060
14Congenital primary aphakia (HP:0007707)2.98789059
15Abnormality of the renal cortex (HP:0011035)2.98674116
16Lissencephaly (HP:0001339)2.88637530
17Abnormality of the renal medulla (HP:0100957)2.79798692
18Nephrogenic diabetes insipidus (HP:0009806)2.76709881
19Hypothermia (HP:0002045)2.75021636
20Polydipsia (HP:0001959)2.65020363
21Abnormal drinking behavior (HP:0030082)2.65020363
22Acute necrotizing encephalopathy (HP:0006965)2.64778953
23Pendular nystagmus (HP:0012043)2.64167447
24Pachygyria (HP:0001302)2.63397902
25Progressive macrocephaly (HP:0004481)2.59080256
26Chronic hepatic failure (HP:0100626)2.57207156
27Hypsarrhythmia (HP:0002521)2.57104774
28Intestinal atresia (HP:0011100)2.56848273
29EEG with generalized epileptiform discharges (HP:0011198)2.54897409
30Abnormal rod and cone electroretinograms (HP:0008323)2.53447661
31Drooling (HP:0002307)2.49762883
32Epileptiform EEG discharges (HP:0011182)2.49415641
33Tubular atrophy (HP:0000092)2.48841070
34Retinal dysplasia (HP:0007973)2.48102306
35Attenuation of retinal blood vessels (HP:0007843)2.46675262
36Genital tract atresia (HP:0001827)2.44586854
37Hepatic necrosis (HP:0002605)2.44114411
38Renal cortical cysts (HP:0000803)2.41174665
39Large for gestational age (HP:0001520)2.39968994
40Febrile seizures (HP:0002373)2.38833074
41Polyphagia (HP:0002591)2.36875103
42Vaginal atresia (HP:0000148)2.32641700
43Hepatocellular necrosis (HP:0001404)2.32244568
44Mitochondrial inheritance (HP:0001427)2.31355165
45Excessive salivation (HP:0003781)2.22907008
46Abnormality of the labia minora (HP:0012880)2.21839499
47Broad-based gait (HP:0002136)2.20532914
48Ketoacidosis (HP:0001993)2.20037144
49Poor coordination (HP:0002370)2.19994477
50Acute encephalopathy (HP:0006846)2.19932397
51Cystic liver disease (HP:0006706)2.18511825
52Inability to walk (HP:0002540)2.16688390
53Abnormal mitochondria in muscle tissue (HP:0008316)2.15207811
54Epileptic encephalopathy (HP:0200134)2.10769904
55Bony spicule pigmentary retinopathy (HP:0007737)2.09803005
56Congenital sensorineural hearing impairment (HP:0008527)2.08363182
57Increased CSF lactate (HP:0002490)2.06238000
58Progressive cerebellar ataxia (HP:0002073)2.03865307
59Absent speech (HP:0001344)2.03697374
60Abnormal albumin level (HP:0012116)2.02176694
61Hypoalbuminemia (HP:0003073)2.02176694
62Sclerocornea (HP:0000647)2.00722630
63Dialeptic seizures (HP:0011146)2.00163009
64Hemiparesis (HP:0001269)1.99401343
65Polyuria (HP:0000103)1.98932229
66Abnormal biliary tract physiology (HP:0012439)1.98695987
67Bile duct proliferation (HP:0001408)1.98695987
68Hypoglycemic coma (HP:0001325)1.97201283
69Gaze-evoked nystagmus (HP:0000640)1.97006968
70Muscular hypotonia of the trunk (HP:0008936)1.96984096
71Occipital encephalocele (HP:0002085)1.94500909
72Cerebellar dysplasia (HP:0007033)1.92971831
73Aplasia/Hypoplasia of the tibia (HP:0005772)1.90542278
74Ketosis (HP:0001946)1.90472220
753-Methylglutaconic aciduria (HP:0003535)1.89837236
76Specific learning disability (HP:0001328)1.89690429
77Spastic tetraplegia (HP:0002510)1.88061094
78Adrenal hypoplasia (HP:0000835)1.86634814
79Lipid accumulation in hepatocytes (HP:0006561)1.86335213
80Postaxial hand polydactyly (HP:0001162)1.86038475
81Protruding tongue (HP:0010808)1.85864442
82Narrow forehead (HP:0000341)1.85262681
83Abolished electroretinogram (ERG) (HP:0000550)1.85025209
84Optic nerve hypoplasia (HP:0000609)1.82885696
85Glycosuria (HP:0003076)1.76018038
86Abnormality of urine glucose concentration (HP:0011016)1.76018038
87Aplasia/Hypoplasia of the tongue (HP:0010295)1.74915575
88Aplasia/hypoplasia of the uterus (HP:0008684)1.74773618
89Esotropia (HP:0000565)1.73819564
90Absence seizures (HP:0002121)1.73426252
91Progressive inability to walk (HP:0002505)1.73335744
92Late onset (HP:0003584)1.73211748
93Rib fusion (HP:0000902)1.72034840
94Optic disc pallor (HP:0000543)1.71816488
95Focal motor seizures (HP:0011153)1.69589333
96Severe muscular hypotonia (HP:0006829)1.67994251
97Increased corneal curvature (HP:0100692)1.67627904
98Keratoconus (HP:0000563)1.67627904
99Left ventricular hypertrophy (HP:0001712)1.66570020
100Volvulus (HP:0002580)1.66543639

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.14128137
2MAP4K24.02695990
3CASK3.23687058
4PINK13.06163175
5MARK12.91694420
6TNIK2.58063543
7MAP3K42.52032393
8WNK32.41956560
9GRK12.33315917
10ADRBK22.24029729
11MAPK132.04513885
12PAK31.91985957
13MKNK21.86756186
14NUAK11.83020307
15STK161.82602645
16TAOK31.79134728
17DYRK21.76227865
18MAP2K71.71621326
19DAPK21.69305477
20NTRK31.61735462
21WNK41.56226114
22TRIM281.51926389
23PNCK1.49842365
24BMPR1B1.48059516
25PHKG21.46544920
26PHKG11.46544920
27PRKCG1.41170693
28CSNK1G21.40820075
29MAP2K61.40355947
30BCR1.38515169
31CSNK1G31.38214195
32CSNK1G11.31026981
33MINK11.25784711
34PRKCE1.17535582
35SIK21.06258765
36INSRR1.00173804
37CSNK1A1L0.99947959
38FGFR20.95504415
39ERBB30.95463272
40EPHA40.95264874
41SRPK10.89648843
42AKT30.88494202
43MAP2K40.88448982
44PLK20.88251679
45NTRK20.85540791
46STK38L0.83778096
47ZAK0.81898959
48STK390.81680430
49SGK20.78630224
50SGK2230.78265280
51SGK4940.78265280
52ACVR1B0.78061858
53MAP3K90.76270394
54CAMK2A0.75212477
55OXSR10.74428496
56ADRBK10.71155842
57EIF2AK30.69899891
58MKNK10.69662075
59CAMK2D0.69243092
60LIMK10.67891136
61BCKDK0.67622321
62CAMKK20.65106476
63PRKCZ0.61609240
64PRKCI0.60988861
65EPHA30.59744887
66PRKCH0.58762432
67STK30.58106075
68CAMK1G0.57969626
69CSNK1A10.57758955
70PRKD30.57359064
71UHMK10.55114835
72WEE10.54322057
73IRAK10.51464309
74DYRK1A0.51462682
75STK110.49967201
76HIPK20.48796218
77CDK50.48382170
78PKN10.48008606
79PRKAA10.47982072
80DYRK30.46241263
81PAK60.45321714
82MAP3K60.45108635
83PRKACA0.44915898
84TAF10.44711928
85CSNK1D0.44675019
86CDK30.44427338
87NME10.43463092
88PRKG10.40879723
89MAPKAPK50.40201841
90TSSK60.39727532
91CSNK1E0.39615695
92MAP3K120.38886442
93EIF2AK20.36107501
94VRK10.34532370
95PTK2B0.34288515
96CAMK2B0.34199128
97SGK10.32948888
98RPS6KA50.32597102
99CAMK40.31225153
100MAP3K50.31114716

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.25116122
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.07146516
3Nicotine addiction_Homo sapiens_hsa050332.79567627
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.73185385
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.73139015
6Butanoate metabolism_Homo sapiens_hsa006502.55846511
7Selenocompound metabolism_Homo sapiens_hsa004502.43213988
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.39852194
9Phototransduction_Homo sapiens_hsa047442.37828419
10Protein export_Homo sapiens_hsa030602.22795370
11Sulfur metabolism_Homo sapiens_hsa009201.94320063
12Oxidative phosphorylation_Homo sapiens_hsa001901.92954235
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.92069524
14Linoleic acid metabolism_Homo sapiens_hsa005911.89777882
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.82202647
16Ether lipid metabolism_Homo sapiens_hsa005651.79648795
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.70547063
18Insulin secretion_Homo sapiens_hsa049111.69510571
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.65147723
20Circadian entrainment_Homo sapiens_hsa047131.57209592
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.56919730
22Morphine addiction_Homo sapiens_hsa050321.55436036
23GABAergic synapse_Homo sapiens_hsa047271.55241923
24Collecting duct acid secretion_Homo sapiens_hsa049661.47375532
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.43965172
26Parkinsons disease_Homo sapiens_hsa050121.43235565
27Synaptic vesicle cycle_Homo sapiens_hsa047211.42503867
28Glutamatergic synapse_Homo sapiens_hsa047241.41449062
29Propanoate metabolism_Homo sapiens_hsa006401.40874685
30Dopaminergic synapse_Homo sapiens_hsa047281.40427965
31Taste transduction_Homo sapiens_hsa047421.39282913
32Cocaine addiction_Homo sapiens_hsa050301.35209130
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.33629386
34Tryptophan metabolism_Homo sapiens_hsa003801.30764810
35Circadian rhythm_Homo sapiens_hsa047101.19807805
36Peroxisome_Homo sapiens_hsa041461.18726712
37RNA polymerase_Homo sapiens_hsa030201.17549439
38Regulation of autophagy_Homo sapiens_hsa041401.13373867
39Serotonergic synapse_Homo sapiens_hsa047261.10423868
40Steroid biosynthesis_Homo sapiens_hsa001001.10232772
41Fatty acid elongation_Homo sapiens_hsa000621.09406156
42Nitrogen metabolism_Homo sapiens_hsa009101.08114081
43Basal transcription factors_Homo sapiens_hsa030221.02460868
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00759948
45Amphetamine addiction_Homo sapiens_hsa050310.99149825
46Olfactory transduction_Homo sapiens_hsa047400.97163497
47Fatty acid metabolism_Homo sapiens_hsa012120.97114168
48Cardiac muscle contraction_Homo sapiens_hsa042600.93931321
49Fatty acid biosynthesis_Homo sapiens_hsa000610.93044635
50Long-term depression_Homo sapiens_hsa047300.91906264
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90192347
52ABC transporters_Homo sapiens_hsa020100.86192794
53beta-Alanine metabolism_Homo sapiens_hsa004100.86173390
54RNA degradation_Homo sapiens_hsa030180.83980609
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83004577
56Alzheimers disease_Homo sapiens_hsa050100.82336190
57Huntingtons disease_Homo sapiens_hsa050160.80573359
58Fatty acid degradation_Homo sapiens_hsa000710.79732031
59Salivary secretion_Homo sapiens_hsa049700.78511030
60Caffeine metabolism_Homo sapiens_hsa002320.74426754
61Purine metabolism_Homo sapiens_hsa002300.72335353
62Vitamin B6 metabolism_Homo sapiens_hsa007500.71265482
63Metabolic pathways_Homo sapiens_hsa011000.67427704
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66254680
65Sphingolipid metabolism_Homo sapiens_hsa006000.65765118
66Fat digestion and absorption_Homo sapiens_hsa049750.63540648
67Ovarian steroidogenesis_Homo sapiens_hsa049130.62814259
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62258521
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61514177
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.60287695
71Arachidonic acid metabolism_Homo sapiens_hsa005900.60048809
72Chemical carcinogenesis_Homo sapiens_hsa052040.58817135
73Type II diabetes mellitus_Homo sapiens_hsa049300.58587083
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.58226239
75Folate biosynthesis_Homo sapiens_hsa007900.57356921
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57276167
77Cholinergic synapse_Homo sapiens_hsa047250.56795973
78Renin secretion_Homo sapiens_hsa049240.56431691
79One carbon pool by folate_Homo sapiens_hsa006700.55925349
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54319341
81Retinol metabolism_Homo sapiens_hsa008300.54318125
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.53603697
83Calcium signaling pathway_Homo sapiens_hsa040200.52713830
84Fanconi anemia pathway_Homo sapiens_hsa034600.50536267
85Axon guidance_Homo sapiens_hsa043600.48987860
86Vibrio cholerae infection_Homo sapiens_hsa051100.48418496
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44096422
88cAMP signaling pathway_Homo sapiens_hsa040240.43019674
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42140219
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42035533
91Non-homologous end-joining_Homo sapiens_hsa034500.41912850
92Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.41505573
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40460857
94Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38716253
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38680080
96Gastric acid secretion_Homo sapiens_hsa049710.36681465
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36049610
98Pyruvate metabolism_Homo sapiens_hsa006200.34365647
99Pancreatic secretion_Homo sapiens_hsa049720.32967431
100Oxytocin signaling pathway_Homo sapiens_hsa049210.29059558

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