NAPSB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1immunoglobulin mediated immune response (GO:0016064)6.70509773
2antigen processing and presentation of endogenous antigen (GO:0019883)6.02881141
3regulation of B cell receptor signaling pathway (GO:0050855)5.71069751
4positive regulation of gamma-delta T cell activation (GO:0046645)5.60373904
5B cell receptor signaling pathway (GO:0050853)5.35567719
6B cell mediated immunity (GO:0019724)5.32319377
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.30671995
8positive regulation by organism of defense response of other organism involved in symbiotic interact5.30671995
9modulation by symbiont of host immune response (GO:0052553)5.30671995
10positive regulation by symbiont of host defense response (GO:0052509)5.30671995
11modulation by symbiont of host defense response (GO:0052031)5.30671995
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.30671995
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.29854159
14interferon-gamma-mediated signaling pathway (GO:0060333)5.10190206
15regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.07540484
16detection of bacterium (GO:0016045)4.94922390
17antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.90309142
18macrophage activation involved in immune response (GO:0002281)4.87949591
19positive thymic T cell selection (GO:0045059)4.81421916
20detection of other organism (GO:0098543)4.78708781
21regulation of interferon-beta biosynthetic process (GO:0045357)4.78349638
22neutrophil activation involved in immune response (GO:0002283)4.68078192
23regulation of antigen processing and presentation (GO:0002577)4.66145984
24regulation of dendritic cell antigen processing and presentation (GO:0002604)4.64653634
25antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.62815966
26negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.60119140
27negative regulation of cell killing (GO:0031342)4.60119140
28positive regulation of type 2 immune response (GO:0002830)4.24065131
29positive regulation of antigen processing and presentation (GO:0002579)4.23196312
30positive regulation of mast cell activation (GO:0033005)4.15474378
31type I interferon signaling pathway (GO:0060337)4.13789250
32cellular response to type I interferon (GO:0071357)4.13789250
33defense response to protozoan (GO:0042832)4.12558882
34positive regulation of B cell differentiation (GO:0045579)4.09280615
35response to type I interferon (GO:0034340)4.08374570
36response to peptidoglycan (GO:0032494)4.07970326
37positive regulation of mast cell degranulation (GO:0043306)4.07900306
38positive regulation of mast cell activation involved in immune response (GO:0033008)4.07900306
39regulation of B cell differentiation (GO:0045577)4.01690292
40antigen processing and presentation via MHC class Ib (GO:0002475)3.92109951
41T cell costimulation (GO:0031295)3.92102141
42regulation of gamma-delta T cell activation (GO:0046643)3.90568510
43microglial cell activation (GO:0001774)3.86514184
44lymphocyte costimulation (GO:0031294)3.86489019
45cellular response to interferon-gamma (GO:0071346)3.85314488
46detection of external biotic stimulus (GO:0098581)3.83115575
47response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.81576634
48response to host immune response (GO:0052572)3.81576634
49negative thymic T cell selection (GO:0045060)3.81317551
50regulation of mast cell degranulation (GO:0043304)3.75825745
51positive T cell selection (GO:0043368)3.69225418
52myeloid cell activation involved in immune response (GO:0002275)3.66221765
53positive regulation of interferon-alpha production (GO:0032727)3.65041460
54response to protozoan (GO:0001562)3.61194722
55antigen receptor-mediated signaling pathway (GO:0050851)3.61032032
56B cell proliferation (GO:0042100)3.56987573
57regulation of mast cell activation (GO:0033003)3.56903659
58T cell selection (GO:0045058)3.56373243
59negative T cell selection (GO:0043383)3.54475198
60thymic T cell selection (GO:0045061)3.52663631
61positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.48556488
62positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.48083730
63response to host (GO:0075136)3.47127507
64response to host defenses (GO:0052200)3.47127507
65response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.47127507
66regulation of mast cell activation involved in immune response (GO:0033006)3.46203345
67regulation of T-helper 2 cell differentiation (GO:0045628)3.43911417
68response to interferon-gamma (GO:0034341)3.43821484
69production of molecular mediator involved in inflammatory response (GO:0002532)3.43061243
70regulation of hypersensitivity (GO:0002883)3.42049203
71regulation of interferon-alpha production (GO:0032647)3.40263053
72positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.36512451
73positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.34807137
74NIK/NF-kappaB signaling (GO:0038061)3.34345398
75detection of biotic stimulus (GO:0009595)3.32961076
76regulation of type 2 immune response (GO:0002828)3.31861456
77regulation of alpha-beta T cell proliferation (GO:0046640)3.30567561
78regulation of T cell tolerance induction (GO:0002664)3.30396991
79regulation of gamma-delta T cell differentiation (GO:0045586)3.28770785
80respiratory burst (GO:0045730)3.28490798
81regulation of myeloid leukocyte mediated immunity (GO:0002886)3.27051280
82B cell homeostasis (GO:0001782)3.25130565
83negative regulation of lymphocyte mediated immunity (GO:0002707)3.22282299
84macrophage activation (GO:0042116)3.18630856
85regulation of tolerance induction (GO:0002643)3.13152759
86germinal center formation (GO:0002467)3.13040646
87neutrophil activation (GO:0042119)3.11736248
88regulation of germinal center formation (GO:0002634)3.11433936
89positive regulation of B cell proliferation (GO:0030890)3.09883422
90T-helper 1 type immune response (GO:0042088)3.08871881
91T cell migration (GO:0072678)3.08721729
92cellular extravasation (GO:0045123)3.07409345
93negative regulation of interleukin-12 production (GO:0032695)3.06811978
94negative regulation of T cell mediated immunity (GO:0002710)3.06778973
95regulation of B cell proliferation (GO:0030888)3.06552886
96adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli3.06039281
97regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.05290260
98positive regulation of B cell activation (GO:0050871)3.03590096
99regulation of MHC class I biosynthetic process (GO:0045343)3.02612927
100regulation of leukocyte degranulation (GO:0043300)3.00969933

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.87678466
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.94338621
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.39162338
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.90343067
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.47565421
6MYC_22102868_ChIP-Seq_BL_Human3.40803588
7SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.36666457
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.35976356
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.23085446
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.20829748
11IRF8_27001747_Chip-Seq_BMDM_Mouse3.19463388
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.16821670
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.05987557
14SPI1_23547873_ChIP-Seq_NB4_Human2.86814593
15VDR_21846776_ChIP-Seq_THP-1_Human2.76812325
16E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.76795087
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.63829339
18MYB_26560356_Chip-Seq_TH2_Human2.55568476
19VDR_24763502_ChIP-Seq_THP-1_Human2.51100054
20RUNX_20019798_ChIP-Seq_JUKART_Human2.43105272
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.38676071
22CIITA_25753668_ChIP-Seq_RAJI_Human2.37998296
23* MAF_26560356_Chip-Seq_TH1_Human2.34328498
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.28047182
25MYB_21317192_ChIP-Seq_ERMYB_Mouse2.23282258
26SPI1_23127762_ChIP-Seq_K562_Human2.20763186
27MYB_26560356_Chip-Seq_TH1_Human2.19135020
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.16272172
29SCL_19346495_ChIP-Seq_HPC-7_Human2.15528213
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.08502795
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.08342166
32UTX_26944678_Chip-Seq_JUKART_Human2.04106528
33RUNX1_22412390_ChIP-Seq_EML_Mouse2.01681557
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.97337436
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.92241438
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.92228957
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.86081223
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.84027197
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.77475799
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.76976629
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.75188650
42MAF_26560356_Chip-Seq_TH2_Human1.69013978
43GATA3_27048872_Chip-Seq_THYMUS_Human1.68484722
44RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.67957698
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.54705146
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.51007011
47TCF7_22412390_ChIP-Seq_EML_Mouse1.49409813
48LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.41660642
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.39625145
50NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.38790568
51GATA3_26560356_Chip-Seq_TH2_Human1.38649662
52CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35485462
53* VDR_24787735_ChIP-Seq_THP-1_Human1.33297335
54KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.33278173
55THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30501168
56NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.30436059
57Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29834233
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.29584934
59KDM2B_26808549_Chip-Seq_DND41_Human1.29211642
60BCL6_27268052_Chip-Seq_Bcells_Human1.26467658
61PU.1_20513432_ChIP-Seq_Bcells_Mouse1.26117548
62PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25504467
63LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24856869
64PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22444146
65KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.22144586
66TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20727911
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19934958
68VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.18861051
69CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16394553
70GATA1_19941827_ChIP-Seq_MEL_Mouse1.15134208
71CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14990573
72TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14493264
73GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13140702
74SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12322377
75LXR_22292898_ChIP-Seq_THP-1_Human1.12322314
76PU_27001747_Chip-Seq_BMDM_Mouse1.11747020
77PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10496942
78CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09858562
79GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09088025
80* BCOR_27268052_Chip-Seq_Bcells_Human1.08848243
81TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08073389
82ELF1_20517297_ChIP-Seq_JURKAT_Human1.00968727
83SMRT_27268052_Chip-Seq_Bcells_Human0.97473683
84GATA1_22025678_ChIP-Seq_K562_Human0.96533165
85* P300_27268052_Chip-Seq_Bcells_Human0.94604096
86SMAD_19615063_ChIP-ChIP_OVARY_Human0.94585914
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92304303
88PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88596820
89* SPI1_20517297_ChIP-Seq_HL60_Human0.87383934
90RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86644405
91STAT1_20625510_ChIP-Seq_HELA_Human0.85841945
92* ELK3_25401928_ChIP-Seq_HUVEC_Human0.84811729
93NCOR1_26117541_ChIP-Seq_K562_Human0.79354042
94GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78090447
95SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76656396
96FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76254768
97SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76145997
98STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.75414895
99RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.74606110
100CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74546504

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.97279370
2MP0001800_abnormal_humoral_immune3.96722147
3MP0005671_abnormal_response_to3.83023436
4MP0001790_abnormal_immune_system3.67450802
5MP0005387_immune_system_phenotype3.67450802
6MP0000685_abnormal_immune_system3.64828678
7MP0003303_peritoneal_inflammation3.46787308
8MP0005000_abnormal_immune_tolerance3.35456725
9MP0003436_decreased_susceptibility_to3.30201469
10MP0002452_abnormal_antigen_presenting3.21825419
11MP0003724_increased_susceptibility_to3.10845104
12MP0002723_abnormal_immune_serum3.05937456
13MP0009785_altered_susceptibility_to2.96661222
14MP0005025_abnormal_response_to2.88038070
15MP0002420_abnormal_adaptive_immunity2.85516978
16MP0001819_abnormal_immune_cell2.84971997
17MP0002419_abnormal_innate_immunity2.77899493
18MP0003763_abnormal_thymus_physiology2.55594099
19MP0002148_abnormal_hypersensitivity_rea2.45287011
20MP0002398_abnormal_bone_marrow2.31444647
21MP0006082_CNS_inflammation2.27733844
22MP0000716_abnormal_immune_system2.22298921
23MP0003183_abnormal_peptide_metabolism2.05133696
24MP0002166_altered_tumor_susceptibility2.05010752
25MP0010155_abnormal_intestine_physiology2.00632083
26MP0005464_abnormal_platelet_physiology1.97085532
27MP0002138_abnormal_hepatobiliary_system1.96852998
28MP0000689_abnormal_spleen_morphology1.92938828
29MP0002405_respiratory_system_inflammati1.89992365
30MP0001845_abnormal_inflammatory_respons1.83156256
31MP0002429_abnormal_blood_cell1.77445343
32MP0003300_gastrointestinal_ulcer1.76228275
33MP0001873_stomach_inflammation1.70661603
34MP0002722_abnormal_immune_system1.68542493
35MP0003172_abnormal_lysosome_physiology1.67909687
36MP0005310_abnormal_salivary_gland1.67245954
37MP0002396_abnormal_hematopoietic_system1.65180936
38MP0003866_abnormal_defecation1.56509523
39MP0009333_abnormal_splenocyte_physiolog1.55444105
40MP0008469_abnormal_protein_level1.49015192
41MP0000465_gastrointestinal_hemorrhage1.47160113
42MP0001533_abnormal_skeleton_physiology1.46456629
43MP0005451_abnormal_body_composition1.42099290
44MP0001853_heart_inflammation1.41691069
45MP0004947_skin_inflammation1.38632324
46MP0008260_abnormal_autophagy1.33735823
47MP0000703_abnormal_thymus_morphology1.33423026
48MP0002006_tumorigenesis1.30265781
49MP0009764_decreased_sensitivity_to1.26054837
50MP0001986_abnormal_taste_sensitivity1.24502907
51MP0003191_abnormal_cellular_cholesterol1.19299879
52MP0005166_decreased_susceptibility_to1.17977638
53MP0005075_abnormal_melanosome_morpholog1.16257916
54MP0003075_altered_response_to1.12448670
55MP0000858_altered_metastatic_potential1.11186019
56MP0002132_abnormal_respiratory_system1.08522655
57MP0002009_preneoplasia1.04261083
58MP0001348_abnormal_lacrimal_gland0.99773476
59MP0005397_hematopoietic_system_phenotyp0.94105868
60MP0001545_abnormal_hematopoietic_system0.94105868
61MP0001663_abnormal_digestive_system0.93101932
62MP0009278_abnormal_bone_marrow0.92921779
63MP0002998_abnormal_bone_remodeling0.91629594
64MP0009763_increased_sensitivity_to0.84705569
65MP0003828_pulmonary_edema0.83571287
66MP0004883_abnormal_blood_vessel0.82541823
67MP0003806_abnormal_nucleotide_metabolis0.82195958
68MP0005058_abnormal_lysosome_morphology0.81702286
69MP0001851_eye_inflammation0.81272128
70MP0004381_abnormal_hair_follicle0.78436019
71MP0000490_abnormal_crypts_of0.75888005
72MP0003045_fibrosis0.75496562
73MP0004510_myositis0.74588927
74MP0000249_abnormal_blood_vessel0.72215601
75MP0000015_abnormal_ear_pigmentation0.68864336
76MP0004808_abnormal_hematopoietic_stem0.68830288
77MP0002019_abnormal_tumor_incidence0.67610556
78MP0002933_joint_inflammation0.65806903
79MP0003690_abnormal_glial_cell0.65339830
80MP0003252_abnormal_bile_duct0.64846429
81MP0000343_altered_response_to0.60969601
82MP0003091_abnormal_cell_migration0.60748171
83MP0003448_altered_tumor_morphology0.59083692
84MP0002136_abnormal_kidney_physiology0.55497655
85MP0008004_abnormal_stomach_pH0.53493534
86MP0005645_abnormal_hypothalamus_physiol0.52186821
87MP0002928_abnormal_bile_duct0.51521110
88MP0005381_digestive/alimentary_phenotyp0.51030149
89MP0008874_decreased_physiological_sensi0.50247565
90MP0002693_abnormal_pancreas_physiology0.50073740
91MP0005390_skeleton_phenotype0.46672099
92MP0003795_abnormal_bone_structure0.46229128
93MP0002277_abnormal_respiratory_mucosa0.45408141
94MP0005584_abnormal_enzyme/coenzyme_acti0.44965511
95MP0006036_abnormal_mitochondrial_physio0.44442833
96MP0005164_abnormal_response_to0.43245996
97MP0000609_abnormal_liver_physiology0.41220460
98MP0009642_abnormal_blood_homeostasis0.40916348
99MP0000371_diluted_coat_color0.40508557
100MP0000313_abnormal_cell_death0.36715565

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)6.22226297
2Meningitis (HP:0001287)5.58646687
3Eczematoid dermatitis (HP:0000976)5.34110046
4Recurrent bacterial skin infections (HP:0005406)5.23293944
5Chronic obstructive pulmonary disease (HP:0006510)5.00328310
6Obstructive lung disease (HP:0006536)5.00328310
7Recurrent abscess formation (HP:0002722)5.00213091
8Vasculitis (HP:0002633)4.78555238
9Mediastinal lymphadenopathy (HP:0100721)4.77537027
10Gastrointestinal stroma tumor (HP:0100723)4.65211799
11Chronic mucocutaneous candidiasis (HP:0002728)4.47318891
12Recurrent cutaneous fungal infections (HP:0011370)4.47318891
13Cellulitis (HP:0100658)4.40000787
14Recurrent fungal infections (HP:0002841)4.32295351
15Abnormality of macrophages (HP:0004311)4.22844102
16Abnormal delayed hypersensitivity skin test (HP:0002963)4.20428169
17Recurrent gram-negative bacterial infections (HP:0005420)4.09658811
18Recurrent bronchitis (HP:0002837)4.09419393
19Panhypogammaglobulinemia (HP:0003139)4.08418487
20Gastrointestinal infarctions (HP:0005244)4.06126184
21Colitis (HP:0002583)4.03092262
22Recurrent skin infections (HP:0001581)4.01250810
23Recurrent viral infections (HP:0004429)3.98504535
24Recurrent sinusitis (HP:0011108)3.98326150
25Hemoptysis (HP:0002105)3.63379317
26Chest pain (HP:0100749)3.62745890
27Pulmonary infiltrates (HP:0002113)3.62022703
28Elevated erythrocyte sedimentation rate (HP:0003565)3.60869148
29Inflammation of the large intestine (HP:0002037)3.57396908
30Myositis (HP:0100614)3.56568361
31Urticaria (HP:0001025)3.56457816
32Abnormality of the prostate (HP:0008775)3.53491748
33Lymphopenia (HP:0001888)3.52488862
34Gastrointestinal inflammation (HP:0004386)3.47765858
35Osteomyelitis (HP:0002754)3.47212293
36Restrictive lung disease (HP:0002091)3.39132763
37Papilloma (HP:0012740)3.34141154
38Verrucae (HP:0200043)3.34141154
39Encephalitis (HP:0002383)3.26561517
40Abnormality of cells of the lymphoid lineage (HP:0012140)3.26116506
41Skin rash (HP:0000988)3.22749382
42Abnormality of the pleura (HP:0002103)3.22644273
43Emphysema (HP:0002097)3.22163540
44Recurrent pneumonia (HP:0006532)3.22045214
45Optic neuritis (HP:0100653)3.20296486
46Retrobulbar optic neuritis (HP:0100654)3.20296486
47Orchitis (HP:0100796)3.19629494
48Increased IgE level (HP:0003212)3.03291604
49IgM deficiency (HP:0002850)2.98458098
50Recurrent lower respiratory tract infections (HP:0002783)2.97873426
51Stomatitis (HP:0010280)2.83467106
52Chronic otitis media (HP:0000389)2.77819561
53Sepsis (HP:0100806)2.77002243
54Epistaxis (HP:0000421)2.70211106
55Gingivitis (HP:0000230)2.64753850
56Chronic sinusitis (HP:0011109)2.63716450
57Abnormality of T cell physiology (HP:0011840)2.57804995
58Increased IgM level (HP:0003496)2.55704029
59Skin ulcer (HP:0200042)2.55586834
60Abnormality of T cells (HP:0002843)2.49300864
61Prolonged bleeding time (HP:0003010)2.48417847
62Gingival bleeding (HP:0000225)2.47860457
63Pulmonary embolism (HP:0002204)2.46903077
64Gangrene (HP:0100758)2.45996089
65Petechiae (HP:0000967)2.43093611
66Spontaneous hematomas (HP:0007420)2.42930339
67Arterial thrombosis (HP:0004420)2.41230160
68Glomerulopathy (HP:0100820)2.40641973
69Amyloidosis (HP:0011034)2.39454853
70IgG deficiency (HP:0004315)2.38226517
71Abnormality of the peritoneum (HP:0002585)2.37932200
72Keratoconjunctivitis sicca (HP:0001097)2.37792177
73Acrocyanosis (HP:0001063)2.37723538
74Fatigue (HP:0012378)2.34859075
75Pustule (HP:0200039)2.33696696
76Pulmonary fibrosis (HP:0002206)2.32206353
77Viral hepatitis (HP:0006562)2.30647815
78Bronchitis (HP:0012387)2.30198121
79Keratoconjunctivitis (HP:0001096)2.28564273
80Chronic diarrhea (HP:0002028)2.24524051
81Abnormality of B cell number (HP:0010975)2.24471485
82Hypertensive crisis (HP:0100735)2.23142119
83Lymphoma (HP:0002665)2.23046706
84Amaurosis fugax (HP:0100576)2.21136604
85Abnormality of male internal genitalia (HP:0000022)2.18677340
86Abnormality of T cell number (HP:0011839)2.15595822
87Leukocytosis (HP:0001974)2.15402927
88Granulocytopenia (HP:0001913)2.14781559
89Arthralgia (HP:0002829)2.14670306
90T lymphocytopenia (HP:0005403)2.13890051
91Anorexia (HP:0002039)2.11048097
92Recurrent otitis media (HP:0000403)2.09515045
93B lymphocytopenia (HP:0010976)2.09512533
94Xerostomia (HP:0000217)2.08787063
95Hypoplasia of the thymus (HP:0000778)2.07818637
96Systemic lupus erythematosus (HP:0002725)2.05284415
97Purpura (HP:0000979)2.04855218
98Hypergammaglobulinemia (HP:0010702)2.03972648
99Polyneuropathy (HP:0001271)2.01925351
100Ureteral stenosis (HP:0000071)1.97678293

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.21311230
2RIPK44.99278746
3BLK3.98453336
4TYK23.19210412
5ERN13.00534488
6BMPR22.73296747
7CSF1R2.66729659
8IRAK42.64446068
9JAK32.60437980
10SYK2.43790474
11MAP3K132.26734842
12BTK2.26293474
13MAP3K142.21527133
14FES2.11458308
15KIT2.05113119
16PRPF4B2.02866913
17IKBKE1.97364203
18CSK1.85343786
19CDK191.83229180
20LYN1.76017246
21TNK21.62408588
22TBK11.60430870
23ITK1.56272768
24JAK11.53238146
25GRK61.50016751
26MAP2K31.49646080
27IKBKB1.48433655
28MAP3K101.47489245
29ZAP701.47092819
30HCK1.45313619
31SIK31.41031321
32TEC1.34460192
33TESK21.24176538
34FGR1.22784780
35LCK1.22187695
36TXK1.19920180
37SIK21.11538930
38PIK3CG1.07823040
39JAK21.03152428
40MARK30.96341145
41PDK10.94625444
42MATK0.90011035
43MAPK120.87408588
44STK100.82844714
45PRKCQ0.76739111
46MAPK70.75795147
47TAOK30.71999714
48MAP3K110.71407451
49SMG10.71043801
50MAP3K30.69144108
51MAPK110.68270077
52KDR0.67581432
53PDPK10.65530838
54FGFR40.64628727
55MAP3K10.64079881
56CDC42BPA0.63942312
57FYN0.60164534
58TLK10.57459883
59LRRK20.57385300
60PASK0.57167677
61CDK40.56500467
62TAOK10.56152111
63TRIB30.52235606
64RPS6KA40.50357989
65TAOK20.50274372
66HIPK20.49634973
67PIM10.48417528
68YES10.48246495
69IRAK10.44660873
70SCYL20.43922482
71MAP3K80.43711048
72ABL10.43683748
73FGFR30.43666806
74MOS0.43578270
75IRAK20.42745989
76MARK20.42714036
77NEK90.41332067
78KSR20.41149972
79CHUK0.40903092
80MAP2K20.40879482
81MAPKAPK20.39193802
82MAP3K120.38453382
83GRK70.36224470
84SIK10.34661338
85CDK120.34214598
86EPHB10.34151625
87NME20.33895567
88MAPK40.33579324
89PRKCD0.33428161
90MAP3K70.30707114
91RPS6KC10.30573429
92RPS6KL10.30573429
93EGFR0.29876603
94OXSR10.28569176
95CCNB10.28039733
96ARAF0.26587377
97TGFBR20.25307376
98MST40.24284718
99RPS6KA60.23279371
100DYRK1B0.22474911

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053105.09140855
2Allograft rejection_Homo sapiens_hsa053304.88026973
3Autoimmune thyroid disease_Homo sapiens_hsa053204.74735298
4Graft-versus-host disease_Homo sapiens_hsa053324.55972935
5Intestinal immune network for IgA production_Homo sapiens_hsa046724.16483188
6Type I diabetes mellitus_Homo sapiens_hsa049403.88627326
7Staphylococcus aureus infection_Homo sapiens_hsa051503.37510204
8Leishmaniasis_Homo sapiens_hsa051403.26503250
9Viral myocarditis_Homo sapiens_hsa054163.02010213
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.94861715
11Antigen processing and presentation_Homo sapiens_hsa046122.90867651
12Primary immunodeficiency_Homo sapiens_hsa053402.50005945
13B cell receptor signaling pathway_Homo sapiens_hsa046622.33590640
14Tuberculosis_Homo sapiens_hsa051521.93787624
15Rheumatoid arthritis_Homo sapiens_hsa053231.86898781
16Toxoplasmosis_Homo sapiens_hsa051451.80914391
17Influenza A_Homo sapiens_hsa051641.79459171
18Herpes simplex infection_Homo sapiens_hsa051681.77973623
19Hematopoietic cell lineage_Homo sapiens_hsa046401.71554678
20Osteoclast differentiation_Homo sapiens_hsa043801.66990813
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.50104112
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.39822202
23Systemic lupus erythematosus_Homo sapiens_hsa053221.33451569
24Phagosome_Homo sapiens_hsa041451.29463953
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.25215972
26Measles_Homo sapiens_hsa051621.22480073
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17306095
28Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.06862936
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05205977
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.98842364
31Epstein-Barr virus infection_Homo sapiens_hsa051690.98034759
32T cell receptor signaling pathway_Homo sapiens_hsa046600.94527848
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88343013
34NOD-like receptor signaling pathway_Homo sapiens_hsa046210.87160567
35Chemokine signaling pathway_Homo sapiens_hsa040620.86841094
36Jak-STAT signaling pathway_Homo sapiens_hsa046300.75605542
37Pertussis_Homo sapiens_hsa051330.75579954
38HTLV-I infection_Homo sapiens_hsa051660.67555017
39Legionellosis_Homo sapiens_hsa051340.67523087
40Hepatitis B_Homo sapiens_hsa051610.65280503
41Acute myeloid leukemia_Homo sapiens_hsa052210.65230913
42African trypanosomiasis_Homo sapiens_hsa051430.63953407
43Malaria_Homo sapiens_hsa051440.59836216
44Hepatitis C_Homo sapiens_hsa051600.59714448
45Platelet activation_Homo sapiens_hsa046110.59506442
46Other glycan degradation_Homo sapiens_hsa005110.57970995
47TNF signaling pathway_Homo sapiens_hsa046680.54809784
48Shigellosis_Homo sapiens_hsa051310.52536654
49Leukocyte transendothelial migration_Homo sapiens_hsa046700.48841800
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46537658
51Salmonella infection_Homo sapiens_hsa051320.45950729
52Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43939836
53Apoptosis_Homo sapiens_hsa042100.43001033
54SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40477873
55Viral carcinogenesis_Homo sapiens_hsa052030.37053228
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35913544
57Regulation of autophagy_Homo sapiens_hsa041400.34555282
58Non-small cell lung cancer_Homo sapiens_hsa052230.32837859
59Sphingolipid signaling pathway_Homo sapiens_hsa040710.30005114
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28802648
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26177575
62Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25385625
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.22125625
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.22022581
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.21449811
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.21140907
67Pancreatic cancer_Homo sapiens_hsa052120.21070275
68Lysosome_Homo sapiens_hsa041420.17891693
69Endocytosis_Homo sapiens_hsa041440.17826509
70Prolactin signaling pathway_Homo sapiens_hsa049170.16484307
71VEGF signaling pathway_Homo sapiens_hsa043700.15532478
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.14074524
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.12046116
74Chronic myeloid leukemia_Homo sapiens_hsa052200.11594305
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.11165076
76Renal cell carcinoma_Homo sapiens_hsa052110.10745293
77Notch signaling pathway_Homo sapiens_hsa043300.08191605
78HIF-1 signaling pathway_Homo sapiens_hsa040660.06708356
79MAPK signaling pathway_Homo sapiens_hsa040100.05641848
80GnRH signaling pathway_Homo sapiens_hsa049120.05616961
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.05488369
82Ribosome_Homo sapiens_hsa030100.02960261
83FoxO signaling pathway_Homo sapiens_hsa040680.02806021
84Choline metabolism in cancer_Homo sapiens_hsa052310.02762642
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.02111709
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.00392430
87Prostate cancer_Homo sapiens_hsa05215-0.0994381
88Cholinergic synapse_Homo sapiens_hsa04725-0.0986308
89Amoebiasis_Homo sapiens_hsa05146-0.0983952
90mTOR signaling pathway_Homo sapiens_hsa04150-0.0901214
91Regulation of actin cytoskeleton_Homo sapiens_hsa04810-0.0862374
92Type II diabetes mellitus_Homo sapiens_hsa04930-0.0787584
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750-0.0655237
94Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0604425
95Colorectal cancer_Homo sapiens_hsa05210-0.0425871
96Insulin resistance_Homo sapiens_hsa04931-0.0417829
97Inositol phosphate metabolism_Homo sapiens_hsa00562-0.0343708
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760-0.0233489
99Alcoholism_Homo sapiens_hsa05034-0.0091543
100Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0086645

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