NAP1L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this intronless gene is a member of the nucleosome assembly protein (NAP) family. The encoded protein represents a class of tissue-specific factors that interact with chromatin to regulate neuronal cell proliferation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.86093287
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.80708591
3vocalization behavior (GO:0071625)5.41692539
4sodium ion export (GO:0071436)5.33026795
5glutamate secretion (GO:0014047)5.24516564
6regulation of synaptic vesicle exocytosis (GO:2000300)5.20133545
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.19672492
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.09869412
9neuronal action potential propagation (GO:0019227)5.01046718
10synaptic vesicle maturation (GO:0016188)4.99308699
11neuron cell-cell adhesion (GO:0007158)4.87722284
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.85971186
13synaptic vesicle docking involved in exocytosis (GO:0016081)4.85952085
14regulation of glutamate receptor signaling pathway (GO:1900449)4.82946221
15neurotransmitter secretion (GO:0007269)4.70538557
16protein localization to synapse (GO:0035418)4.70100819
17locomotory exploration behavior (GO:0035641)4.69018648
18regulation of synaptic vesicle transport (GO:1902803)4.58107554
19regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.49482800
20ionotropic glutamate receptor signaling pathway (GO:0035235)4.47412604
21L-amino acid import (GO:0043092)4.36285416
22cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.32778623
23potassium ion homeostasis (GO:0055075)4.23083479
24neuron-neuron synaptic transmission (GO:0007270)4.20935771
25synaptic transmission, glutamatergic (GO:0035249)4.13992061
26negative regulation of synaptic transmission, GABAergic (GO:0032229)4.13322781
27glutamate receptor signaling pathway (GO:0007215)4.12980898
28neurotransmitter-gated ion channel clustering (GO:0072578)4.07579675
29gamma-aminobutyric acid transport (GO:0015812)4.05451753
30regulation of neuronal synaptic plasticity (GO:0048168)3.96557325
31regulation of long-term neuronal synaptic plasticity (GO:0048169)3.96329159
32gamma-aminobutyric acid signaling pathway (GO:0007214)3.96133423
33exploration behavior (GO:0035640)3.95674684
34cell communication by electrical coupling (GO:0010644)3.95639530
35amino acid import (GO:0043090)3.91158527
36potassium ion import (GO:0010107)3.90734163
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.85930998
38neurotransmitter transport (GO:0006836)3.84288449
39synaptic vesicle endocytosis (GO:0048488)3.82427686
40proline transport (GO:0015824)3.76111708
41cellular sodium ion homeostasis (GO:0006883)3.75475068
42regulation of excitatory postsynaptic membrane potential (GO:0060079)3.71485507
43neuromuscular process controlling posture (GO:0050884)3.71153889
44positive regulation of dendritic spine morphogenesis (GO:0061003)3.69799940
45presynaptic membrane assembly (GO:0097105)3.67015724
46positive regulation of dendritic spine development (GO:0060999)3.66746207
47regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.66646850
48neuron recognition (GO:0008038)3.63671945
49neurotransmitter uptake (GO:0001504)3.62736557
50regulation of voltage-gated calcium channel activity (GO:1901385)3.62715114
51central nervous system myelination (GO:0022010)3.62117407
52axon ensheathment in central nervous system (GO:0032291)3.62117407
53cerebellar Purkinje cell differentiation (GO:0021702)3.59480920
54long-term synaptic potentiation (GO:0060291)3.58386234
55regulation of synapse structural plasticity (GO:0051823)3.56627803
56regulation of postsynaptic membrane potential (GO:0060078)3.55661198
57regulation of neurotransmitter levels (GO:0001505)3.52117014
58positive regulation of membrane potential (GO:0045838)3.51201806
59presynaptic membrane organization (GO:0097090)3.50543697
60positive regulation of synapse maturation (GO:0090129)3.50541452
61postsynaptic membrane organization (GO:0001941)3.49873164
62layer formation in cerebral cortex (GO:0021819)3.49601494
63regulation of synapse maturation (GO:0090128)3.45770039
64positive regulation of synaptic transmission, GABAergic (GO:0032230)3.44496903
65long-term memory (GO:0007616)3.42227108
66regulation of neurotransmitter secretion (GO:0046928)3.41745828
67auditory behavior (GO:0031223)3.41694103
68transmission of nerve impulse (GO:0019226)3.41125653
69regulation of synaptic plasticity (GO:0048167)3.39980821
70regulation of synaptic transmission, glutamatergic (GO:0051966)3.38893628
71activation of protein kinase A activity (GO:0034199)3.38460501
72negative regulation of dendrite morphogenesis (GO:0050774)3.37837722
73negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.37550365
74positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.37526711
75response to histamine (GO:0034776)3.35375330
76regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.32083884
77regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.31441556
78G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.29736844
79cell migration in hindbrain (GO:0021535)3.23395884
80cerebellar granule cell differentiation (GO:0021707)3.22677073
81positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.22403496
82regulation of neurotransmitter transport (GO:0051588)3.20669815
83regulation of vesicle fusion (GO:0031338)3.18669505
84ATP hydrolysis coupled proton transport (GO:0015991)3.17491453
85energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.17491453
86mating behavior (GO:0007617)3.17267245
87membrane depolarization (GO:0051899)3.17191182
88membrane depolarization during action potential (GO:0086010)3.16405765
89detection of calcium ion (GO:0005513)3.16204377
90positive regulation of neurotransmitter transport (GO:0051590)3.15378094
91synaptic transmission (GO:0007268)3.14542824
92regulation of dendritic spine development (GO:0060998)3.14301436
93cellular potassium ion homeostasis (GO:0030007)3.14161780
94regulation of glutamate secretion (GO:0014048)3.13491228
95dendritic spine morphogenesis (GO:0060997)3.12727641
96acidic amino acid transport (GO:0015800)3.11179624
97regulation of ARF protein signal transduction (GO:0032012)3.10077191
98membrane hyperpolarization (GO:0060081)3.10047240
99cell communication involved in cardiac conduction (GO:0086065)3.09505362
100regulation of dendritic spine morphogenesis (GO:0061001)3.09071064
101positive regulation of synapse assembly (GO:0051965)3.09032862
102axonal fasciculation (GO:0007413)3.08659365
103neuromuscular process controlling balance (GO:0050885)3.07568561
104regulation of synaptic transmission, GABAergic (GO:0032228)3.07308087
105positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.07123711
106cell differentiation in hindbrain (GO:0021533)3.07081777
107transferrin transport (GO:0033572)3.06588388
108establishment of synaptic vesicle localization (GO:0097480)3.06308514
109synaptic vesicle transport (GO:0048489)3.06308514
110synapse assembly (GO:0007416)3.06106950
111behavioral response to cocaine (GO:0048148)3.05969130
112behavioral defense response (GO:0002209)3.05466021
113behavioral fear response (GO:0001662)3.05466021
114startle response (GO:0001964)3.02669406
115positive regulation of synaptic transmission (GO:0050806)3.02504046
116social behavior (GO:0035176)3.02177774
117intraspecies interaction between organisms (GO:0051703)3.02177774
118adult walking behavior (GO:0007628)3.01557298
119neuromuscular process (GO:0050905)3.01358316
120neuromuscular synaptic transmission (GO:0007274)3.01303884
121regulation of respiratory system process (GO:0044065)2.99817310
122regulation of synaptic transmission (GO:0050804)2.99290814
123learning (GO:0007612)2.98962510
124striatum development (GO:0021756)2.97061194
125negative regulation of dendrite development (GO:2000171)2.96271620
126neuronal ion channel clustering (GO:0045161)2.94733449
127positive regulation of neurotransmitter secretion (GO:0001956)2.94554123

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.80121786
2GBX2_23144817_ChIP-Seq_PC3_Human4.01247186
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.17174695
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.04136219
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.02070427
6REST_21632747_ChIP-Seq_MESCs_Mouse2.94724418
7JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60398183
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60032929
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60032929
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58210708
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.50103483
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48468038
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46772641
14RARB_27405468_Chip-Seq_BRAIN_Mouse2.45973692
15TAF15_26573619_Chip-Seq_HEK293_Human2.45742572
16REST_18959480_ChIP-ChIP_MESCs_Mouse2.45670023
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.43983331
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.43696110
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.41923694
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.22947894
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.16311060
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15543149
23DROSHA_22980978_ChIP-Seq_HELA_Human2.13292831
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.10491988
25CTBP2_25329375_ChIP-Seq_LNCAP_Human2.10017995
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.08664586
27EZH2_27294783_Chip-Seq_ESCs_Mouse2.08238065
28IKZF1_21737484_ChIP-ChIP_HCT116_Human2.05519183
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94997133
30AR_21572438_ChIP-Seq_LNCaP_Human1.89269322
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.80824614
32* SMAD4_21799915_ChIP-Seq_A2780_Human1.75302549
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.74548986
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.67611444
35* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.67226615
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.61544565
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59673694
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57850795
39P300_19829295_ChIP-Seq_ESCs_Human1.57801148
40ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.53772396
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51570710
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46266625
43RNF2_27304074_Chip-Seq_NSC_Mouse1.43670253
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.41381503
45ZNF274_21170338_ChIP-Seq_K562_Hela1.40681990
46RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.36930985
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36733656
48SOX2_21211035_ChIP-Seq_LN229_Gbm1.36099909
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35049570
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34851629
51VDR_22108803_ChIP-Seq_LS180_Human1.34611074
52AR_25329375_ChIP-Seq_VCAP_Human1.33507831
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.32653687
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32588384
55GATA1_26923725_Chip-Seq_HPCs_Mouse1.32176958
56IGF1R_20145208_ChIP-Seq_DFB_Human1.31729762
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28704753
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26013088
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23275745
60THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23012535
61STAT3_23295773_ChIP-Seq_U87_Human1.22999909
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22764882
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.21002844
64RING1B_27294783_Chip-Seq_ESCs_Mouse1.20784352
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19181790
66FUS_26573619_Chip-Seq_HEK293_Human1.18436376
67SMAD_19615063_ChIP-ChIP_OVARY_Human1.17076998
68TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16926476
69AR_19668381_ChIP-Seq_PC3_Human1.14451895
70P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13128017
71TCF4_23295773_ChIP-Seq_U87_Human1.11410733
72TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09362627
73DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08031512
74RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07647864
75MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06339536
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04195941
77RING1B_27294783_Chip-Seq_NPCs_Mouse1.03234305
78RUNX2_22187159_ChIP-Seq_PCA_Human1.02239272
79TET1_21490601_ChIP-Seq_MESCs_Mouse1.01536219
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01524194
81CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01385896
82YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01083300
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.00951819
84LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00430620
85ER_23166858_ChIP-Seq_MCF-7_Human0.98546859
86JUN_21703547_ChIP-Seq_K562_Human0.97773017
87KDM2B_26808549_Chip-Seq_K562_Human0.96747904
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96568791
89TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96238828
90AHR_22903824_ChIP-Seq_MCF-7_Human0.95818317
91ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95232659
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94815596
93WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.94447814
94PRDM14_20953172_ChIP-Seq_ESCs_Human0.94321582
95OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.93217198
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92987345
97WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92925290
98SMAD3_21741376_ChIP-Seq_ESCs_Human0.91767836
99NANOG_18555785_Chip-Seq_ESCs_Mouse0.90107164
100HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.88929768
101TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88677888
102ZFP281_18757296_ChIP-ChIP_E14_Mouse0.88000447
103KDM2B_26808549_Chip-Seq_REH_Human0.84803299
104ZNF217_24962896_ChIP-Seq_MCF-7_Human0.84708624
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.84513277
106TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84513277
107CDX2_19796622_ChIP-Seq_MESCs_Mouse0.84485745
108STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.83877003
109CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.83864971
110CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83327229
111SOX9_26525672_Chip-Seq_HEART_Mouse0.82074986
112* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.79753797
113SMAD4_21741376_ChIP-Seq_HESCs_Human0.79629502
114NR3C1_21868756_ChIP-Seq_MCF10A_Human0.78785742
115EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.78623516

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.62017689
2MP0003880_abnormal_central_pattern5.18227098
3MP0003635_abnormal_synaptic_transmissio4.03819350
4MP0009046_muscle_twitch3.57921200
5MP0004270_analgesia3.50040553
6MP0009745_abnormal_behavioral_response3.41513371
7MP0002064_seizures3.32175086
8MP0002063_abnormal_learning/memory/cond3.28119901
9MP0001968_abnormal_touch/_nociception3.27064503
10MP0002572_abnormal_emotion/affect_behav2.92306961
11MP0002272_abnormal_nervous_system2.77158148
12MP0002736_abnormal_nociception_after2.75419066
13MP0002734_abnormal_mechanical_nocicepti2.69881106
14MP0002735_abnormal_chemical_nociception2.56693952
15MP0005423_abnormal_somatic_nervous2.51644600
16MP0001486_abnormal_startle_reflex2.44598929
17MP0001501_abnormal_sleep_pattern2.37835842
18MP0002822_catalepsy2.26692029
19MP0001440_abnormal_grooming_behavior2.25260879
20MP0002733_abnormal_thermal_nociception2.19703922
21MP0002067_abnormal_sensory_capabilities2.19023477
22MP0006276_abnormal_autonomic_nervous2.17506581
23MP0001970_abnormal_pain_threshold2.13333449
24MP0002184_abnormal_innervation1.89708576
25MP0004924_abnormal_behavior1.81970962
26MP0005386_behavior/neurological_phenoty1.81970962
27MP0008569_lethality_at_weaning1.80181833
28MP0003122_maternal_imprinting1.77908259
29MP0001529_abnormal_vocalization1.76853155
30MP0002557_abnormal_social/conspecific_i1.74371735
31MP0005646_abnormal_pituitary_gland1.73520247
32MP0004142_abnormal_muscle_tone1.73245254
33MP0000778_abnormal_nervous_system1.72370293
34MP0004811_abnormal_neuron_physiology1.70220123
35MP0001984_abnormal_olfaction1.69039391
36MP0003787_abnormal_imprinting1.67297533
37MP0009780_abnormal_chondrocyte_physiolo1.65181372
38MP0005645_abnormal_hypothalamus_physiol1.64500549
39MP0003879_abnormal_hair_cell1.59604147
40MP0000955_abnormal_spinal_cord1.59577744
41MP0003329_amyloid_beta_deposits1.58764246
42MP0003123_paternal_imprinting1.58140481
43MP0002909_abnormal_adrenal_gland1.52888448
44MP0004858_abnormal_nervous_system1.50688105
45MP0002066_abnormal_motor_capabilities/c1.45785196
46MP0002882_abnormal_neuron_morphology1.40707973
47MP0003690_abnormal_glial_cell1.36517244
48MP0001905_abnormal_dopamine_level1.30049450
49MP0000920_abnormal_myelination1.27125935
50MP0002837_dystrophic_cardiac_calcinosis1.26830398
51MP0003633_abnormal_nervous_system1.24290266
52MP0001502_abnormal_circadian_rhythm1.22549725
53MP0000013_abnormal_adipose_tissue1.22365257
54MP0001188_hyperpigmentation1.20882321
55MP0000751_myopathy1.13193291
56MP0004147_increased_porphyrin_level1.08566224
57MP0004885_abnormal_endolymph1.06013136
58MP0002152_abnormal_brain_morphology1.05927286
59MP0003631_nervous_system_phenotype1.04956593
60MP0002229_neurodegeneration1.00164057
61MP0008872_abnormal_physiological_respon0.98892446
62MP0004233_abnormal_muscle_weight0.96998289
63MP0005551_abnormal_eye_electrophysiolog0.93421468
64MP0010386_abnormal_urinary_bladder0.93414217
65MP0004145_abnormal_muscle_electrophysio0.93323796
66MP0002069_abnormal_eating/drinking_beha0.92186214
67MP0002876_abnormal_thyroid_physiology0.89945460
68MP0005171_absent_coat_pigmentation0.89661752
69MP0004742_abnormal_vestibular_system0.89476614
70MP0001963_abnormal_hearing_physiology0.87972386
71MP0005394_taste/olfaction_phenotype0.87689911
72MP0005499_abnormal_olfactory_system0.87689911
73MP0008874_decreased_physiological_sensi0.83065346
74MP0002752_abnormal_somatic_nervous0.81898124
75MP0003634_abnormal_glial_cell0.79352362
76MP0005535_abnormal_body_temperature0.76285818
77MP0004085_abnormal_heartbeat0.75411354
78MP0000631_abnormal_neuroendocrine_gland0.74170998
79MP0003283_abnormal_digestive_organ0.72351286
80MP0008877_abnormal_DNA_methylation0.71167788
81MP0004215_abnormal_myocardial_fiber0.68763081
82MP0003632_abnormal_nervous_system0.68732347
83MP0004484_altered_response_of0.67227107
84MP0001485_abnormal_pinna_reflex0.67145208
85MP0001664_abnormal_digestion0.66395274
86MP0006072_abnormal_retinal_apoptosis0.65256169
87MP0000569_abnormal_digit_pigmentation0.64734233
88MP0001986_abnormal_taste_sensitivity0.64690695
89MP0001943_abnormal_respiration0.63818880
90MP0001299_abnormal_eye_distance/0.63531088
91MP0001177_atelectasis0.63011673
92MP0003121_genomic_imprinting0.62629376
93MP0003183_abnormal_peptide_metabolism0.62467187
94MP0002638_abnormal_pupillary_reflex0.61909112
95MP0000604_amyloidosis0.61448280
96MP0003137_abnormal_impulse_conducting0.60958860
97MP0003861_abnormal_nervous_system0.59896834
98MP0003646_muscle_fatigue0.59696810
99MP0002653_abnormal_ependyma_morphology0.58620624
100MP0002090_abnormal_vision0.58233569
101MP0004043_abnormal_pH_regulation0.56969025
102MP0005623_abnormal_meninges_morphology0.56909897
103MP0001348_abnormal_lacrimal_gland0.56454075
104MP0010770_preweaning_lethality0.56215303
105MP0002082_postnatal_lethality0.56215303
106MP0010769_abnormal_survival0.56087071
107MP0000579_abnormal_nail_morphology0.55211975
108MP0001346_abnormal_lacrimal_gland0.54303916
109MP0010768_mortality/aging0.53589980
110MP0003956_abnormal_body_size0.53196689
111MP0000026_abnormal_inner_ear0.52548340
112MP0005187_abnormal_penis_morphology0.51445895
113MP0000566_synostosis0.50699522
114MP0005167_abnormal_blood-brain_barrier0.46749094
115MP0003938_abnormal_ear_development0.45177072
116MP0002873_normal_phenotype0.43415259

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.01306245
2Myokymia (HP:0002411)6.25088275
3Atonic seizures (HP:0010819)5.88374327
4Focal seizures (HP:0007359)5.66073943
5Febrile seizures (HP:0002373)5.27558324
6Epileptic encephalopathy (HP:0200134)5.20139006
7Visual hallucinations (HP:0002367)5.07160590
8Absence seizures (HP:0002121)4.67741539
9Progressive cerebellar ataxia (HP:0002073)4.35132491
10Dialeptic seizures (HP:0011146)4.20125234
11Generalized tonic-clonic seizures (HP:0002069)3.92714924
12Hyperventilation (HP:0002883)3.56132800
13Action tremor (HP:0002345)3.43527392
14Neurofibrillary tangles (HP:0002185)3.41642233
15Pheochromocytoma (HP:0002666)3.34313693
16Broad-based gait (HP:0002136)3.29881372
17Abnormal eating behavior (HP:0100738)3.23608323
18Gaze-evoked nystagmus (HP:0000640)3.23535285
19Dysdiadochokinesis (HP:0002075)3.16708255
20Impaired vibration sensation in the lower limbs (HP:0002166)3.08556912
21Neuroendocrine neoplasm (HP:0100634)3.03063949
22Cerebral hypomyelination (HP:0006808)3.02268941
23Supranuclear gaze palsy (HP:0000605)3.01608148
24Truncal ataxia (HP:0002078)2.94420653
25Amblyopia (HP:0000646)2.93561214
26Tetraplegia (HP:0002445)2.93128709
27Poor eye contact (HP:0000817)2.91883250
28Failure to thrive in infancy (HP:0001531)2.85436303
29Depression (HP:0000716)2.83734505
30Anxiety (HP:0000739)2.82685883
31Ankle clonus (HP:0011448)2.82199100
32Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.82151340
33Degeneration of the lateral corticospinal tracts (HP:0002314)2.82151340
34Progressive inability to walk (HP:0002505)2.81593991
35Polyphagia (HP:0002591)2.80412486
36Dysmetria (HP:0001310)2.77514516
37Impaired social interactions (HP:0000735)2.74067753
38Abnormal social behavior (HP:0012433)2.74067753
39Fetal akinesia sequence (HP:0001989)2.64090365
40Obstructive sleep apnea (HP:0002870)2.63827532
41Urinary bladder sphincter dysfunction (HP:0002839)2.62177559
42Epileptiform EEG discharges (HP:0011182)2.61705907
43Morphological abnormality of the pyramidal tract (HP:0002062)2.59376232
44Gait imbalance (HP:0002141)2.58646063
45Abnormal hair whorl (HP:0010721)2.58344084
46Scanning speech (HP:0002168)2.55433535
47Limb dystonia (HP:0002451)2.55038310
48Craniofacial dystonia (HP:0012179)2.54020583
49Abnormality of binocular vision (HP:0011514)2.49162559
50Diplopia (HP:0000651)2.49162559
51Abnormality of the lower motor neuron (HP:0002366)2.47573647
52Excessive salivation (HP:0003781)2.47013864
53Drooling (HP:0002307)2.47013864
54EEG with generalized epileptiform discharges (HP:0011198)2.45768956
55Poor suck (HP:0002033)2.41130184
56Postural instability (HP:0002172)2.38054796
57Urinary urgency (HP:0000012)2.35338199
58Genetic anticipation (HP:0003743)2.35326846
59Neuronal loss in central nervous system (HP:0002529)2.35204054
60Impaired smooth pursuit (HP:0007772)2.34739322
61Mutism (HP:0002300)2.33961633
62Termporal pattern (HP:0011008)2.33834401
63Insidious onset (HP:0003587)2.33834401
64Hypsarrhythmia (HP:0002521)2.33431691
65Status epilepticus (HP:0002133)2.32770513
66Dysmetric saccades (HP:0000641)2.32600326
67Spastic tetraparesis (HP:0001285)2.32141629
68Peripheral hypomyelination (HP:0007182)2.31619738
69Rigidity (HP:0002063)2.30727063
70Hemiparesis (HP:0001269)2.28665733
71Bradykinesia (HP:0002067)2.27660484
72Specific learning disability (HP:0001328)2.25985881
73Spastic gait (HP:0002064)2.25164319
74Clonus (HP:0002169)2.24543935
75Congenital primary aphakia (HP:0007707)2.23204224
76Inability to walk (HP:0002540)2.22255462
77Apathy (HP:0000741)2.21281182
78Abnormality of the labia minora (HP:0012880)2.15608947
79Choreoathetosis (HP:0001266)2.14841783
80Annular pancreas (HP:0001734)2.14824478
81Narrow nasal bridge (HP:0000446)2.14113715
82Medial flaring of the eyebrow (HP:0010747)2.12278480
83Impaired vibratory sensation (HP:0002495)2.08817051
84Abnormality of saccadic eye movements (HP:0000570)2.08522652
85Abnormality of the corticospinal tract (HP:0002492)2.08502584
86Torticollis (HP:0000473)2.08080325
87Nephrogenic diabetes insipidus (HP:0009806)2.06705402
88Resting tremor (HP:0002322)2.05921925
89Generalized myoclonic seizures (HP:0002123)2.04900061
90Absent speech (HP:0001344)2.04789290
91Neoplasm of the peripheral nervous system (HP:0100007)2.03135921
92Focal dystonia (HP:0004373)2.01982449
93Hypoventilation (HP:0002791)2.01888642
94Increased circulating renin level (HP:0000848)2.01298977
95Abnormality of ocular smooth pursuit (HP:0000617)2.00715703
96Acute necrotizing encephalopathy (HP:0006965)1.99576635
97Diminished motivation (HP:0000745)1.97403076
98Esotropia (HP:0000565)1.96962578
99Spastic tetraplegia (HP:0002510)1.95126495
100Megalencephaly (HP:0001355)1.94918284
101Abnormal mitochondria in muscle tissue (HP:0008316)1.94742169
102Stereotypic behavior (HP:0000733)1.94289700
103Oligomenorrhea (HP:0000876)1.93432791
104CNS hypomyelination (HP:0003429)1.93400167
105Akinesia (HP:0002304)1.93330401
106Agitation (HP:0000713)1.92890311
107Psychosis (HP:0000709)1.92835296
108Progressive macrocephaly (HP:0004481)1.92048083
109Delusions (HP:0000746)1.91492755
110Blue irides (HP:0000635)1.91476701
111Ventricular fibrillation (HP:0001663)1.89850553
112Papilledema (HP:0001085)1.89545748
113Incomplete penetrance (HP:0003829)1.88901431
114Rapidly progressive (HP:0003678)1.88842793
115Lower limb muscle weakness (HP:0007340)1.88685196
116Cerebral inclusion bodies (HP:0100314)1.88263066
117Intention tremor (HP:0002080)1.87556221
118Hemiplegia (HP:0002301)1.87161256
119Protruding tongue (HP:0010808)1.86622396
120Amyotrophic lateral sclerosis (HP:0007354)1.86421914
121Gait ataxia (HP:0002066)1.85870181
122Sleep apnea (HP:0010535)1.85130302
123Muscular hypotonia of the trunk (HP:0008936)1.84559640
124Generalized hypotonia (HP:0001290)1.82543620
125Diminished movement (HP:0002374)1.78857587
126Bundle branch block (HP:0011710)1.76728280
127Postural tremor (HP:0002174)1.73286520
128Paraplegia (HP:0010550)1.68561043
129Prolonged QT interval (HP:0001657)1.68320563

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.32307827
2CASK3.44598835
3MAP3K43.44452132
4MAP3K93.37197886
5EPHA43.28109650
6MAP3K123.25780063
7MAP2K73.04734820
8MARK12.75174748
9MINK12.70714831
10MAP2K42.19836024
11DAPK22.15153336
12CDK192.12231514
13DAPK12.03871732
14NTRK21.84917614
15PLK21.81105046
16PAK61.71090820
17GRK51.61282311
18RIPK41.56100220
19PRPF4B1.49812962
20KSR21.47794614
21ARAF1.47429538
22NTRK11.42561466
23UHMK11.40551760
24CDK51.39405359
25AKT31.38402485
26PNCK1.37595624
27MAPK131.33234495
28KSR11.31546953
29PRKCG1.27855687
30CAMKK11.22604525
31OXSR11.20858073
32TNIK1.12871596
33PINK11.10161227
34CAMK2A1.08469450
35CAMKK21.07967589
36PHKG21.07561935
37PHKG11.07561935
38SIK21.07446639
39STK381.01950771
40LATS20.99786680
41FES0.99130982
42SGK2230.98384015
43SGK4940.98384015
44TYRO30.97404662
45NME10.93272602
46PRKD30.93269755
47CAMK2B0.93263685
48CDK180.90232979
49MAP3K60.89310891
50ALK0.89174244
51SGK20.88679850
52CDK140.86131292
53SIK30.84889999
54CDK150.84758404
55CCNB10.84391183
56TNK20.80857395
57FGR0.80255124
58CDK11A0.72828453
59MAP3K20.71839768
60CAMK40.71477389
61BMPR20.69037363
62RIPK10.69012898
63MAPK120.67553075
64STK110.64692664
65MAP3K130.64078884
66RAF10.63473537
67PDK30.63469495
68PDK40.63469495
69BRAF0.62853374
70SGK10.62693127
71PTK2B0.62019854
72NEK10.61943708
73SGK30.61935634
74CAMK2G0.61815569
75PRKCE0.61747605
76MAPKAPK50.61608068
77TSSK60.60795655
78FGFR20.60646165
79DYRK1A0.59759357
80CAMK2D0.59079767
81LMTK20.59003669
82CAMK10.58799608
83PRKCH0.58535618
84NEK60.58257507
85CSNK1G20.57234869
86FER0.55396046
87GRK70.55341060
88RET0.54111439
89WNK30.52707529
90TAOK10.51943538
91PAK30.51630689
92BCR0.50637691
93DDR20.49178863
94PKN10.48672166
95ADRBK10.47965620
96IRAK20.47385369
97WNK10.46530420
98BRSK10.45981810
99CDC42BPA0.45946725
100LIMK10.45267292
101PRKCZ0.44485002
102MAP3K10.43084016
103RPS6KA30.42615682
104DYRK20.41431730
105MAP2K10.41329814
106PDK10.40336936
107PDPK10.39273727
108CSNK1G30.39261302
109ROCK20.38052055
110CSNK1E0.37980714
111CAMK1G0.37472846
112MAPK100.37090191
113MARK20.36846891
114MAP3K110.36499400
115PRKCA0.35397542
116FYN0.35363187
117DAPK30.34682445
118CSNK1D0.33483593
119PRKG10.31364790
120STK390.31359813
121PRKACA0.29278359
122PRKCB0.29089424
123CSNK1G10.28512311

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.13307352
2Synaptic vesicle cycle_Homo sapiens_hsa047213.98578791
3GABAergic synapse_Homo sapiens_hsa047272.83233707
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.78688310
5Olfactory transduction_Homo sapiens_hsa047402.67866943
6Collecting duct acid secretion_Homo sapiens_hsa049662.62724127
7Long-term potentiation_Homo sapiens_hsa047202.54637671
8Morphine addiction_Homo sapiens_hsa050322.52894215
9Circadian entrainment_Homo sapiens_hsa047132.51808348
10Amphetamine addiction_Homo sapiens_hsa050312.42173931
11Glutamatergic synapse_Homo sapiens_hsa047242.39071110
12Dopaminergic synapse_Homo sapiens_hsa047282.16333463
13Taste transduction_Homo sapiens_hsa047422.07904329
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.05778420
15Salivary secretion_Homo sapiens_hsa049701.98296473
16Insulin secretion_Homo sapiens_hsa049111.92318674
17Long-term depression_Homo sapiens_hsa047301.74134304
18Serotonergic synapse_Homo sapiens_hsa047261.70713453
19Cholinergic synapse_Homo sapiens_hsa047251.70364046
20Gastric acid secretion_Homo sapiens_hsa049711.65990410
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.63923434
22Vibrio cholerae infection_Homo sapiens_hsa051101.63747712
23Renin secretion_Homo sapiens_hsa049241.61182047
24Oxidative phosphorylation_Homo sapiens_hsa001901.56599154
25Cocaine addiction_Homo sapiens_hsa050301.53171301
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.51903123
27Calcium signaling pathway_Homo sapiens_hsa040201.51291627
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49523069
29Oxytocin signaling pathway_Homo sapiens_hsa049211.46421532
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.35100358
31Gap junction_Homo sapiens_hsa045401.33946805
32Vitamin B6 metabolism_Homo sapiens_hsa007501.32634784
33Cardiac muscle contraction_Homo sapiens_hsa042601.30589526
34GnRH signaling pathway_Homo sapiens_hsa049121.26389150
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26107137
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23939608
37Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.22554133
38Parkinsons disease_Homo sapiens_hsa050121.14750194
39Alzheimers disease_Homo sapiens_hsa050101.14170326
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10541039
41cAMP signaling pathway_Homo sapiens_hsa040241.08100870
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04921933
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.02753527
44Estrogen signaling pathway_Homo sapiens_hsa049151.00326826
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99872462
46ErbB signaling pathway_Homo sapiens_hsa040120.97985223
47Phototransduction_Homo sapiens_hsa047440.94249377
48Type II diabetes mellitus_Homo sapiens_hsa049300.94039878
49Axon guidance_Homo sapiens_hsa043600.93336982
50Oocyte meiosis_Homo sapiens_hsa041140.88784353
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86522451
52Glioma_Homo sapiens_hsa052140.86209152
53Melanogenesis_Homo sapiens_hsa049160.85299763
54cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83679294
55Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79406074
56Huntingtons disease_Homo sapiens_hsa050160.77031970
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.75317349
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.72060642
59Bile secretion_Homo sapiens_hsa049760.68381438
60Type I diabetes mellitus_Homo sapiens_hsa049400.67778489
61MAPK signaling pathway_Homo sapiens_hsa040100.66747894
62Dorso-ventral axis formation_Homo sapiens_hsa043200.65787678
63Pancreatic secretion_Homo sapiens_hsa049720.63442853
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62394956
65Thyroid hormone synthesis_Homo sapiens_hsa049180.61173622
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61161347
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60389508
68Rheumatoid arthritis_Homo sapiens_hsa053230.60012366
69Choline metabolism in cancer_Homo sapiens_hsa052310.54227940
70Dilated cardiomyopathy_Homo sapiens_hsa054140.54173139
71Glucagon signaling pathway_Homo sapiens_hsa049220.53939325
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.51002909
73Circadian rhythm_Homo sapiens_hsa047100.49246054
74Ras signaling pathway_Homo sapiens_hsa040140.48729462
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48490194
76Phagosome_Homo sapiens_hsa041450.48196513
77Inositol phosphate metabolism_Homo sapiens_hsa005620.46466293
78Alcoholism_Homo sapiens_hsa050340.46148344
79Arginine and proline metabolism_Homo sapiens_hsa003300.45507244
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.44255035
81mTOR signaling pathway_Homo sapiens_hsa041500.42096721
82VEGF signaling pathway_Homo sapiens_hsa043700.41239523
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40956222
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40906906
85Rap1 signaling pathway_Homo sapiens_hsa040150.38124449
86Insulin signaling pathway_Homo sapiens_hsa049100.37941785
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37749466
88Wnt signaling pathway_Homo sapiens_hsa043100.37041100
89Regulation of autophagy_Homo sapiens_hsa041400.35693096
90Arginine biosynthesis_Homo sapiens_hsa002200.35605111
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35407819
92Endocytosis_Homo sapiens_hsa041440.35313895
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.33355464
94Prion diseases_Homo sapiens_hsa050200.32531675
952-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.31849602
96Fatty acid biosynthesis_Homo sapiens_hsa000610.31769906
97Mineral absorption_Homo sapiens_hsa049780.31208906
98Tight junction_Homo sapiens_hsa045300.30939962
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30700612
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29655136
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28617943
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28303430
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.28105093
104Renal cell carcinoma_Homo sapiens_hsa052110.27704059
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27068962
106Endometrial cancer_Homo sapiens_hsa052130.26898011
107Butanoate metabolism_Homo sapiens_hsa006500.26777899
108Hippo signaling pathway_Homo sapiens_hsa043900.26348354
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.25126886
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25041056
111AMPK signaling pathway_Homo sapiens_hsa041520.20964230
112Histidine metabolism_Homo sapiens_hsa003400.20177577
113beta-Alanine metabolism_Homo sapiens_hsa004100.19526219

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