NANOS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)8.63226549
2regulation of female gonad development (GO:2000194)7.90350524
3female gamete generation (GO:0007292)6.40861158
4meiotic cell cycle (GO:0051321)5.94383889
5DNA methylation involved in gamete generation (GO:0043046)5.75517143
6mitotic metaphase plate congression (GO:0007080)5.72662456
7* regulation of meiosis (GO:0040020)5.67560857
8histone H2A monoubiquitination (GO:0035518)5.42753898
9oocyte maturation (GO:0001556)5.41711618
10regulation of exit from mitosis (GO:0007096)5.33233619
11male meiosis (GO:0007140)5.20100603
12regulation of meiosis I (GO:0060631)5.12804859
13negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.07036905
14mitotic chromosome condensation (GO:0007076)5.05923344
15attachment of spindle microtubules to kinetochore (GO:0008608)5.02443839
16maturation of 5.8S rRNA (GO:0000460)4.95718512
17metaphase plate congression (GO:0051310)4.72329089
18histone H2A ubiquitination (GO:0033522)4.66765210
19regulation of histone H3-K27 methylation (GO:0061085)4.63327453
20DNA damage induced protein phosphorylation (GO:0006975)4.62561636
21regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.62223757
22* regulation of meiotic cell cycle (GO:0051445)4.57196808
23meiotic chromosome segregation (GO:0045132)4.56297848
24glycerophospholipid catabolic process (GO:0046475)4.54769006
25establishment of chromosome localization (GO:0051303)4.36797872
26negative regulation of hormone biosynthetic process (GO:0032353)4.30762278
27negative regulation of hormone metabolic process (GO:0032351)4.30762278
28regulation of DNA methylation (GO:0044030)4.24107037
29negative regulation of smooth muscle cell differentiation (GO:0051151)4.10619005
30protein K6-linked ubiquitination (GO:0085020)4.07772167
31microtubule severing (GO:0051013)4.07631999
32mitotic sister chromatid segregation (GO:0000070)4.07321048
33regulation of sister chromatid cohesion (GO:0007063)4.07282329
34base-excision repair, AP site formation (GO:0006285)3.99669178
35regulation of retinoic acid receptor signaling pathway (GO:0048385)3.94874910
36female gonad development (GO:0008585)3.88471094
37positive regulation of meiosis (GO:0045836)3.85336858
38negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.76777508
39negative regulation of DNA-templated transcription, elongation (GO:0032785)3.76777508
40chaperone-mediated protein transport (GO:0072321)3.75388861
41chromosome segregation (GO:0007059)3.72343360
42positive regulation of megakaryocyte differentiation (GO:0045654)3.69314395
43DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.68967616
44positive regulation of meiotic cell cycle (GO:0051446)3.67247259
45regulation of acrosome reaction (GO:0060046)3.66742464
46DNA damage response, signal transduction resulting in transcription (GO:0042772)3.65537874
47pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.62629951
48DNA alkylation (GO:0006305)3.54102249
49DNA methylation (GO:0006306)3.54102249
50kinetochore assembly (GO:0051382)3.50661128
51positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.50636191
52gene silencing by RNA (GO:0031047)3.46950002
53righting reflex (GO:0060013)3.46916613
54chromatin remodeling at centromere (GO:0031055)3.44495964
55monoubiquitinated protein deubiquitination (GO:0035520)3.42753155
56CENP-A containing nucleosome assembly (GO:0034080)3.39361581
57negative regulation of reproductive process (GO:2000242)3.39314989
58oogenesis (GO:0048477)3.28276690
59phosphatidylglycerol biosynthetic process (GO:0006655)3.26375145
60type B pancreatic cell development (GO:0003323)3.25146987
61snRNA transcription (GO:0009301)3.21911067
62sphingosine metabolic process (GO:0006670)3.21519446
63notochord development (GO:0030903)3.21004938
64regulation of transforming growth factor beta2 production (GO:0032909)3.20147007
65sister chromatid cohesion (GO:0007062)3.20096774
66protein localization to chromosome (GO:0034502)3.19235733
67positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.18611525
68microtubule nucleation (GO:0007020)3.17154144
69meiotic nuclear division (GO:0007126)3.16447643
70multicellular organism reproduction (GO:0032504)3.15870841
71DNA replication-independent nucleosome assembly (GO:0006336)3.15829083
72DNA replication-independent nucleosome organization (GO:0034724)3.15829083
73male meiosis I (GO:0007141)3.15449402
74spindle checkpoint (GO:0031577)3.15316959
75sister chromatid segregation (GO:0000819)3.14189015
76histone exchange (GO:0043486)3.13055873
77mitotic sister chromatid cohesion (GO:0007064)3.12638738
78parturition (GO:0007567)3.12344659
79negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.12320581
80regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.11989668
81regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.11989668
82meiotic cell cycle process (GO:1903046)3.09999047
83synaptonemal complex assembly (GO:0007130)3.07676634
84protein localization to kinetochore (GO:0034501)3.07568371
85regulation of chromosome segregation (GO:0051983)3.03012709
86citrulline biosynthetic process (GO:0019240)3.02494507
87regulation of RIG-I signaling pathway (GO:0039535)3.01772161
88positive regulation of DNA-dependent DNA replication (GO:2000105)3.01347352
89kinetochore organization (GO:0051383)3.00332172
90pyrimidine nucleotide catabolic process (GO:0006244)2.99470879
91diol metabolic process (GO:0034311)2.99144015
92protein localization to chromosome, centromeric region (GO:0071459)2.97678912
93regulation of cell maturation (GO:1903429)2.97030962
94positive regulation of chromosome segregation (GO:0051984)2.96284743
95protein monoubiquitination (GO:0006513)2.93211323
96regulation of spindle organization (GO:0090224)2.93029431
97regulation of mitotic spindle organization (GO:0060236)2.92356818
98cellular response to gamma radiation (GO:0071480)2.90554753
99regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.90409638
100meiosis I (GO:0007127)2.84689286

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human3.52766619
2EZH2_22144423_ChIP-Seq_EOC_Human3.44986588
3MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.18913640
4SMAD_19615063_ChIP-ChIP_OVARY_Human3.02688735
5KAP1_22055183_ChIP-Seq_ESCs_Mouse2.95731469
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.80402647
7IGF1R_20145208_ChIP-Seq_DFB_Human2.56482792
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.47180864
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.41632520
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.36750707
11SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.28378289
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.27553280
13GBX2_23144817_ChIP-Seq_PC3_Human2.23444186
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.23162843
15E2F7_22180533_ChIP-Seq_HELA_Human2.06711718
16GATA1_26923725_Chip-Seq_HPCs_Mouse2.05856054
17RNF2_27304074_Chip-Seq_NSC_Mouse2.05285038
18MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.94802873
19CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91378484
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83507461
21POU3F2_20337985_ChIP-ChIP_501MEL_Human1.82661245
22FUS_26573619_Chip-Seq_HEK293_Human1.80051946
23LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76772463
24SUZ12_27294783_Chip-Seq_NPCs_Mouse1.72560465
25AR_21909140_ChIP-Seq_LNCAP_Human1.71736293
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.66068507
27MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.65606435
28POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.63937771
29TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63937771
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62601421
31STAT3_23295773_ChIP-Seq_U87_Human1.61408726
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59115794
33NANOG_18555785_Chip-Seq_ESCs_Mouse1.58174498
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56897864
35NFE2_27457419_Chip-Seq_LIVER_Mouse1.56839446
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.54304958
37TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.53300405
38RUNX1_26923725_Chip-Seq_HPCs_Mouse1.52008807
39BP1_19119308_ChIP-ChIP_Hs578T_Human1.50563301
40SMAD4_21799915_ChIP-Seq_A2780_Human1.49239382
41TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.46361904
42EZH2_27294783_Chip-Seq_NPCs_Mouse1.45068111
43CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.42718245
44EWS_26573619_Chip-Seq_HEK293_Human1.37485861
45EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.36810814
46KDM2B_26808549_Chip-Seq_REH_Human1.34899078
47NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.34879454
48RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.33304325
49NMYC_18555785_Chip-Seq_ESCs_Mouse1.32514854
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32249152
51STAT1_17558387_ChIP-Seq_HELA_Human1.31550698
52STAT3_18555785_Chip-Seq_ESCs_Mouse1.31315876
53MYC_18940864_ChIP-ChIP_HL60_Human1.30100768
54KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.29807376
55RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29386476
56AR_21572438_ChIP-Seq_LNCaP_Human1.28185593
57SOX2_18555785_Chip-Seq_ESCs_Mouse1.27989920
58CTCF_18555785_Chip-Seq_ESCs_Mouse1.24471513
59TAL1_26923725_Chip-Seq_HPCs_Mouse1.23313176
60KLF4_18555785_Chip-Seq_ESCs_Mouse1.22858642
61E2F1_18555785_Chip-Seq_ESCs_Mouse1.21100856
62OCT4_18555785_Chip-Seq_ESCs_Mouse1.20621945
63ELK4_26923725_Chip-Seq_MESODERM_Mouse1.20163141
64EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.19137290
65LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18136537
66P300_19829295_ChIP-Seq_ESCs_Human1.16061619
67CMYC_18555785_Chip-Seq_ESCs_Mouse1.15732106
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.14585105
69ESRRB_18555785_Chip-Seq_ESCs_Mouse1.14534606
70* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13598464
71SUZ12_18555785_Chip-Seq_ESCs_Mouse1.13282893
72P53_22387025_ChIP-Seq_ESCs_Mouse1.13038182
73ZFX_18555785_Chip-Seq_ESCs_Mouse1.12877581
74CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11918409
75CDX2_22108803_ChIP-Seq_LS180_Human1.11256317
76NFYA_21822215_ChIP-Seq_K562_Human1.10962385
77TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.09327983
78TAF15_26573619_Chip-Seq_HEK293_Human1.08575057
79HTT_18923047_ChIP-ChIP_STHdh_Human1.08562702
80TBL1_22424771_ChIP-Seq_293T_Human1.07396571
81JUN_21703547_ChIP-Seq_K562_Human1.07237953
82AR_25329375_ChIP-Seq_VCAP_Human1.06303368
83JARID2_20064375_ChIP-Seq_MESCs_Mouse1.06046861
84E2F4_17652178_ChIP-ChIP_JURKAT_Human1.05740374
85GATA3_21867929_ChIP-Seq_TH1_Mouse1.05691705
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.04940802
87TP63_19390658_ChIP-ChIP_HaCaT_Human1.03293631
88* TCF4_23295773_ChIP-Seq_U87_Human1.03087133
89RUNX1_27457419_Chip-Seq_LIVER_Mouse1.01376668
90PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00685994
91ESR1_20079471_ChIP-ChIP_T-47D_Human1.00495527
92TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99980784
93SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99670766
94OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99289910
95P300_18555785_Chip-Seq_ESCs_Mouse0.98474644
96FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98160283
97GF1B_26923725_Chip-Seq_HPCs_Mouse0.97675908
98CRX_20693478_ChIP-Seq_RETINA_Mouse0.97410965
99P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97001892
100SOX2_21211035_ChIP-Seq_LN229_Gbm0.96677851

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect5.70233561
2MP0005451_abnormal_body_composition5.63814564
3MP0003646_muscle_fatigue5.59074126
4MP0002102_abnormal_ear_morphology3.97538896
5MP0008877_abnormal_DNA_methylation3.92241371
6MP0003693_abnormal_embryo_hatching3.27790181
7MP0002653_abnormal_ependyma_morphology2.74442950
8MP0010094_abnormal_chromosome_stability2.69716491
9MP0005646_abnormal_pituitary_gland2.63676306
10MP0001119_abnormal_female_reproductive2.60825990
11MP0003787_abnormal_imprinting2.59774827
12MP0003699_abnormal_female_reproductive2.58808162
13MP0005395_other_phenotype2.55858637
14MP0003111_abnormal_nucleus_morphology2.43624017
15MP0006292_abnormal_olfactory_placode2.41343421
16* MP0001929_abnormal_gametogenesis2.15122888
17MP0001529_abnormal_vocalization2.12956970
18MP0003077_abnormal_cell_cycle2.07541240
19MP0000579_abnormal_nail_morphology2.05247505
20* MP0000653_abnormal_sex_gland2.01907884
21* MP0002210_abnormal_sex_determination1.93288379
22MP0003123_paternal_imprinting1.91608490
23MP0003880_abnormal_central_pattern1.90950984
24MP0003937_abnormal_limbs/digits/tail_de1.87950980
25MP0005257_abnormal_intraocular_pressure1.81759356
26MP0004859_abnormal_synaptic_plasticity1.77398524
27MP0010386_abnormal_urinary_bladder1.76126515
28MP0002249_abnormal_larynx_morphology1.74370367
29MP0003121_genomic_imprinting1.73268864
30MP0004957_abnormal_blastocyst_morpholog1.61517519
31MP0005408_hypopigmentation1.61129466
32MP0001905_abnormal_dopamine_level1.56952962
33MP0003315_abnormal_perineum_morphology1.52769257
34* MP0002161_abnormal_fertility/fecundity1.42448526
35MP0002734_abnormal_mechanical_nocicepti1.42092540
36MP0005310_abnormal_salivary_gland1.35393356
37MP0006276_abnormal_autonomic_nervous1.35129629
38MP0008260_abnormal_autophagy1.32896152
39MP0004484_altered_response_of1.29787160
40* MP0001145_abnormal_male_reproductive1.28643394
41MP0004185_abnormal_adipocyte_glucose1.25748514
42MP0000639_abnormal_adrenal_gland1.23405242
43MP0002163_abnormal_gland_morphology1.21396258
44MP0001346_abnormal_lacrimal_gland1.20691549
45MP0002736_abnormal_nociception_after1.18000046
46MP0008932_abnormal_embryonic_tissue1.16510902
47MP0004145_abnormal_muscle_electrophysio1.16201920
48MP0004270_analgesia1.13035801
49MP0001502_abnormal_circadian_rhythm1.09855069
50MP0000462_abnormal_digestive_system1.03187416
51MP0008058_abnormal_DNA_repair1.02319091
52MP0005187_abnormal_penis_morphology1.00345699
53MP0002085_abnormal_embryonic_tissue0.97324571
54MP0000613_abnormal_salivary_gland0.93128433
55MP0010368_abnormal_lymphatic_system0.92435121
56MP0006072_abnormal_retinal_apoptosis0.92078326
57* MP0003698_abnormal_male_reproductive0.91782583
58MP0001919_abnormal_reproductive_system0.87410334
59MP0001968_abnormal_touch/_nociception0.84126454
60MP0003635_abnormal_synaptic_transmissio0.84032509
61MP0000427_abnormal_hair_cycle0.82304757
62MP0000678_abnormal_parathyroid_gland0.80415753
63MP0000631_abnormal_neuroendocrine_gland0.79150830
64MP0005386_behavior/neurological_phenoty0.78617620
65MP0004924_abnormal_behavior0.78617620
66MP0005647_abnormal_sex_gland0.77860309
67MP0008004_abnormal_stomach_pH0.76999625
68MP0002063_abnormal_learning/memory/cond0.76623506
69MP0004782_abnormal_surfactant_physiolog0.74127320
70MP0002733_abnormal_thermal_nociception0.72422357
71MP0005389_reproductive_system_phenotype0.71416949
72MP0003755_abnormal_palate_morphology0.70731967
73MP0005379_endocrine/exocrine_gland_phen0.70686491
74MP0002572_abnormal_emotion/affect_behav0.70531669
75MP0001970_abnormal_pain_threshold0.69973384
76MP0004264_abnormal_extraembryonic_tissu0.68654945
77MP0003861_abnormal_nervous_system0.67579752
78MP0000350_abnormal_cell_proliferation0.66795837
79MP0002084_abnormal_developmental_patter0.65510915
80MP0003329_amyloid_beta_deposits0.65463231
81MP0004510_myositis0.64947460
82MP0002184_abnormal_innervation0.64885497
83MP0000538_abnormal_urinary_bladder0.64569258
84MP0002177_abnormal_outer_ear0.63226814
85MP0001697_abnormal_embryo_size0.62733589
86MP0001730_embryonic_growth_arrest0.62528386
87MP0009250_abnormal_appendicular_skeleto0.62047428
88MP0002735_abnormal_chemical_nociception0.59548700
89MP0000490_abnormal_crypts_of0.56899467
90MP0002067_abnormal_sensory_capabilities0.56455942
91MP0002282_abnormal_trachea_morphology0.56114938
92MP0008057_abnormal_DNA_replication0.55805305
93MP0002332_abnormal_exercise_endurance0.55580007
94MP0002019_abnormal_tumor_incidence0.54288979
95MP0002116_abnormal_craniofacial_bone0.53721593
96MP0001915_intracranial_hemorrhage0.51980926
97MP0002752_abnormal_somatic_nervous0.51885354
98MP0002127_abnormal_cardiovascular_syste0.50283179
99MP0001851_eye_inflammation0.50087214
100MP0002932_abnormal_joint_morphology0.50037329

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)8.48487550
2Chromsome breakage (HP:0040012)5.35498926
3Chromosomal breakage induced by crosslinking agents (HP:0003221)5.02416542
4Infertility (HP:0000789)4.54906355
5Birth length less than 3rd percentile (HP:0003561)4.49535849
6Papillary thyroid carcinoma (HP:0002895)4.39530459
7Oligodactyly (hands) (HP:0001180)4.34722508
8Adrenal hypoplasia (HP:0000835)4.08782607
9Abnormality of the labia minora (HP:0012880)3.96711203
10Premature ovarian failure (HP:0008209)3.78886487
11Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.78653588
12Breast hypoplasia (HP:0003187)3.62599358
13Shawl scrotum (HP:0000049)3.62069759
14Flat capital femoral epiphysis (HP:0003370)3.57451862
15Patellar aplasia (HP:0006443)3.54686253
16Facial hemangioma (HP:0000329)3.49518732
17Secondary amenorrhea (HP:0000869)3.41977322
18Cortical dysplasia (HP:0002539)3.38912502
19Fetal akinesia sequence (HP:0001989)3.35205830
20Oligodactyly (HP:0012165)3.32603213
21Aplasia/Hypoplasia of the patella (HP:0006498)3.22776672
22Breast aplasia (HP:0100783)3.16243739
23Aplasia/Hypoplasia of the breasts (HP:0010311)3.12881768
24Capillary hemangiomas (HP:0005306)3.01488477
25Hypergonadotropic hypogonadism (HP:0000815)2.97459772
26Arterial tortuosity (HP:0005116)2.94939929
27Abnormality of lateral ventricle (HP:0030047)2.82849882
28Pulmonary fibrosis (HP:0002206)2.80147400
29Abnormality of chromosome segregation (HP:0002916)2.79744376
30Abnormal respiratory motile cilium physiology (HP:0012261)2.79428113
31Primary amenorrhea (HP:0000786)2.71867280
32Absent hand (HP:0004050)2.66282708
33Insulin-resistant diabetes mellitus (HP:0000831)2.62900490
34Supernumerary spleens (HP:0009799)2.56392025
35Nonprogressive disorder (HP:0003680)2.54854619
36Abnormality of the fovea (HP:0000493)2.52599648
37Cholecystitis (HP:0001082)2.48712960
38Abnormal gallbladder physiology (HP:0012438)2.48712960
39Vascular tortuosity (HP:0004948)2.46645400
40Hypoplastic iliac wings (HP:0002866)2.43179499
41Abnormality of chromosome stability (HP:0003220)2.41464745
42Aplasia/Hypoplasia of the fovea (HP:0008060)2.41200485
43Hypoplasia of the fovea (HP:0007750)2.41200485
44Abnormality of the fingertips (HP:0001211)2.37381973
45Aplasia/Hypoplasia of the uvula (HP:0010293)2.36590606
46Abnormality of the preputium (HP:0100587)2.30283601
47Aplasia/Hypoplasia of the sternum (HP:0006714)2.28710279
48Thyroid carcinoma (HP:0002890)2.25836824
49Atelectasis (HP:0100750)2.24838835
50Fibular aplasia (HP:0002990)2.20892427
51Prostate neoplasm (HP:0100787)2.19454393
52Focal motor seizures (HP:0011153)2.15791098
53Sandal gap (HP:0001852)2.14624601
54Midline defect of the nose (HP:0004122)2.12062136
55Meckel diverticulum (HP:0002245)2.09232876
56Abnormality of the epiphysis of the femoral head (HP:0010574)2.09102604
57Abnormal ciliary motility (HP:0012262)2.05967287
58Abnormality of placental membranes (HP:0011409)2.05329815
59Amniotic constriction ring (HP:0009775)2.05329815
60Acute myeloid leukemia (HP:0004808)2.03661122
61Pendular nystagmus (HP:0012043)1.99221333
62Duodenal stenosis (HP:0100867)1.97903883
63Small intestinal stenosis (HP:0012848)1.97903883
64Spondylolisthesis (HP:0003302)1.97107398
65Abnormality of the proximal phalanges of the hand (HP:0009834)1.96979255
66Lip pit (HP:0100267)1.96501410
67Febrile seizures (HP:0002373)1.96268210
68Ectopic kidney (HP:0000086)1.96223386
69Absent forearm bone (HP:0003953)1.93946663
70Aplasia involving forearm bones (HP:0009822)1.93946663
71Abnormality of the femoral head (HP:0003368)1.93313945
72Abnormality of the phalanges of the hallux (HP:0010057)1.93279047
73Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.93254583
74Overlapping toe (HP:0001845)1.91690903
75Absent radius (HP:0003974)1.91184226
76Abnormality of the ileum (HP:0001549)1.90652308
77Wrist flexion contracture (HP:0001239)1.89753953
78Short thumb (HP:0009778)1.88614834
79Tetany (HP:0001281)1.88061837
80Abnormality of the clitoris (HP:0000056)1.87544124
81Anomalous pulmonary venous return (HP:0010772)1.87283497
82Anterior segment dysgenesis (HP:0007700)1.87088824
83Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.85194170
84Abnormality of femoral epiphyses (HP:0006499)1.85194170
85Rib fusion (HP:0000902)1.84057538
86Chronic bronchitis (HP:0004469)1.82749665
87Hypogonadotrophic hypogonadism (HP:0000044)1.82583192
88Aplasia/Hypoplasia involving the musculature (HP:0001460)1.81548369
89Azoospermia (HP:0000027)1.77957232
90Abnormality of the carotid arteries (HP:0005344)1.75957071
91Microglossia (HP:0000171)1.75907445
92Atonic seizures (HP:0010819)1.75790843
93Anosmia (HP:0000458)1.74245761
94Type 2 muscle fiber atrophy (HP:0003554)1.72276220
95Clubbing of toes (HP:0100760)1.71771729
96Erectile abnormalities (HP:0100639)1.71206388
97Carpal bone hypoplasia (HP:0001498)1.71193633
98Sloping forehead (HP:0000340)1.70079055
99Cystic hygroma (HP:0000476)1.69605355
100Bundle branch block (HP:0011710)1.68872615

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K64.47604077
2TAOK34.10860822
3LATS14.03194210
4LATS23.68925651
5ERBB43.39593635
6MAP3K93.26844424
7KSR23.08580941
8STK38L3.06756139
9MOS3.05976347
10MUSK2.90171690
11PLK42.87039793
12BMPR22.84155490
13TTK2.63030518
14CDK82.47361327
15BRAF2.44358418
16EEF2K2.38322522
17MAP3K132.31615256
18MAP3K41.90258518
19RAF11.87548662
20PRKD31.83347736
21CDC71.82601006
22ARAF1.77539420
23TAOK11.74122736
24MAP2K71.66599858
25MAPK131.59669993
26DYRK21.54225806
27MELK1.45888301
28STK31.45729007
29PAK61.41892547
30CDK91.36598970
31CHEK21.30502747
32STK381.28625771
33MAPKAPK31.28059087
34KSR11.27147647
35MAPKAPK51.03133098
36DMPK1.00571328
37MAP2K41.00302021
38PLK11.00149904
39NEK20.82438624
40TYRO30.81594208
41PRKD20.81331477
42NTRK20.75529099
43EPHA40.75225892
44STK100.70171231
45ABL20.70057345
46MAP3K80.69914589
47RET0.68047553
48BUB10.65401535
49CSNK1G10.64667436
50PINK10.62750743
51CSNK1G20.62137822
52AURKB0.56931127
53MAPK110.53241254
54NUAK10.52914329
55FGR0.51559045
56CSNK1G30.50766796
57CAMK2A0.50159969
58STK240.47027570
59NLK0.46500469
60AURKA0.45999342
61PRKAA20.45586068
62SGK20.45260376
63MAP3K50.41753073
64PLK20.41702682
65PIK3CG0.41570859
66PRKAA10.41192118
67MAP3K120.37789636
68MARK20.37461604
69CDK30.37456080
70PLK30.36334021
71SGK4940.36259382
72SGK2230.36259382
73ATM0.35610242
74STK110.34993994
75CHEK10.34568545
76HIPK20.33296690
77CSNK1A1L0.32544377
78BMPR1B0.30625361
79TRPM70.30617642
80ABL10.28591179
81NTRK30.27743178
82CDK10.25715743
83BCR0.24235500
84MAP3K10.24211506
85CDK70.22313755
86DYRK30.21581519
87CASK0.21143257
88MAP2K10.20733738
89CDK150.20655020
90CDK180.18801875
91RPS6KB20.17893542
92CDK20.16500880
93JAK30.16133221
94OXSR10.15181094
95EPHA30.15039465
96CCNB10.13290720
97CDK11A0.13276789
98CSNK1D0.12433758
99NTRK10.12286875
100MAPK100.12046438

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049133.98883156
2Cell cycle_Homo sapiens_hsa041103.59403548
3RNA degradation_Homo sapiens_hsa030183.48944513
4Basal transcription factors_Homo sapiens_hsa030223.24938305
5Circadian rhythm_Homo sapiens_hsa047102.99831738
6Vitamin B6 metabolism_Homo sapiens_hsa007502.53086076
7Oocyte meiosis_Homo sapiens_hsa041142.38739628
8Linoleic acid metabolism_Homo sapiens_hsa005912.25735398
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.24234668
10Ether lipid metabolism_Homo sapiens_hsa005652.21656990
11Fanconi anemia pathway_Homo sapiens_hsa034602.21006376
12Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.17163572
13GnRH signaling pathway_Homo sapiens_hsa049122.15266531
14Pancreatic cancer_Homo sapiens_hsa052122.05264300
15Homologous recombination_Homo sapiens_hsa034401.92636346
16Nicotine addiction_Homo sapiens_hsa050331.76217702
17TGF-beta signaling pathway_Homo sapiens_hsa043501.62490673
18Non-homologous end-joining_Homo sapiens_hsa034501.59941884
19Long-term depression_Homo sapiens_hsa047301.53892077
20Choline metabolism in cancer_Homo sapiens_hsa052311.47483512
21RNA polymerase_Homo sapiens_hsa030201.46852101
22Dorso-ventral axis formation_Homo sapiens_hsa043201.45978701
23Colorectal cancer_Homo sapiens_hsa052101.44041536
24Glutamatergic synapse_Homo sapiens_hsa047241.38730296
25RNA transport_Homo sapiens_hsa030131.32691705
26Prolactin signaling pathway_Homo sapiens_hsa049171.29520006
27p53 signaling pathway_Homo sapiens_hsa041151.26737449
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17423328
29Serotonergic synapse_Homo sapiens_hsa047261.17244950
30Base excision repair_Homo sapiens_hsa034101.13488524
31Renal cell carcinoma_Homo sapiens_hsa052111.11327927
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.09087163
33MicroRNAs in cancer_Homo sapiens_hsa052061.05848334
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04980357
35Glycerophospholipid metabolism_Homo sapiens_hsa005641.04256384
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.02986842
37VEGF signaling pathway_Homo sapiens_hsa043701.00507347
38Synaptic vesicle cycle_Homo sapiens_hsa047210.99929812
39mRNA surveillance pathway_Homo sapiens_hsa030150.93889769
40Phospholipase D signaling pathway_Homo sapiens_hsa040720.93052422
41Inositol phosphate metabolism_Homo sapiens_hsa005620.92080063
42Nucleotide excision repair_Homo sapiens_hsa034200.91949342
43Ras signaling pathway_Homo sapiens_hsa040140.91611159
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.89565546
45Hippo signaling pathway_Homo sapiens_hsa043900.88013005
46Endometrial cancer_Homo sapiens_hsa052130.86138581
47FoxO signaling pathway_Homo sapiens_hsa040680.84357128
48Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83503603
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82436064
50ErbB signaling pathway_Homo sapiens_hsa040120.82164647
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.78795301
52Olfactory transduction_Homo sapiens_hsa047400.77965635
53Adherens junction_Homo sapiens_hsa045200.76126826
54Estrogen signaling pathway_Homo sapiens_hsa049150.73701868
55Long-term potentiation_Homo sapiens_hsa047200.72647377
56Mismatch repair_Homo sapiens_hsa034300.72328609
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72086588
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71358337
59Collecting duct acid secretion_Homo sapiens_hsa049660.69367922
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69167890
61Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65901310
62MAPK signaling pathway_Homo sapiens_hsa040100.63386058
63cAMP signaling pathway_Homo sapiens_hsa040240.63317947
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.62491640
65Oxytocin signaling pathway_Homo sapiens_hsa049210.62101758
66Morphine addiction_Homo sapiens_hsa050320.61334765
67Cholinergic synapse_Homo sapiens_hsa047250.58967804
68mTOR signaling pathway_Homo sapiens_hsa041500.57245617
69Wnt signaling pathway_Homo sapiens_hsa043100.56743812
70Non-small cell lung cancer_Homo sapiens_hsa052230.56356534
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56346225
72Other glycan degradation_Homo sapiens_hsa005110.54219400
73DNA replication_Homo sapiens_hsa030300.53798275
74Bladder cancer_Homo sapiens_hsa052190.53094813
75Gap junction_Homo sapiens_hsa045400.52892640
76Hedgehog signaling pathway_Homo sapiens_hsa043400.52619299
77Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51702532
78Purine metabolism_Homo sapiens_hsa002300.50534719
79Taste transduction_Homo sapiens_hsa047420.48239315
80Salivary secretion_Homo sapiens_hsa049700.47798345
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47543467
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47410719
83Thyroid cancer_Homo sapiens_hsa052160.47223197
84Sphingolipid metabolism_Homo sapiens_hsa006000.46509595
85Dopaminergic synapse_Homo sapiens_hsa047280.44335517
86Glioma_Homo sapiens_hsa052140.43823065
87Cocaine addiction_Homo sapiens_hsa050300.43177899
88Amphetamine addiction_Homo sapiens_hsa050310.43105462
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40995730
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39268002
91Arachidonic acid metabolism_Homo sapiens_hsa005900.39157091
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.39001950
93Melanogenesis_Homo sapiens_hsa049160.37047840
94Steroid biosynthesis_Homo sapiens_hsa001000.36282399
95Hepatitis B_Homo sapiens_hsa051610.36206459
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34294596
97GABAergic synapse_Homo sapiens_hsa047270.33259631
98Melanoma_Homo sapiens_hsa052180.32368146
99Small cell lung cancer_Homo sapiens_hsa052220.31505167
100Insulin secretion_Homo sapiens_hsa049110.31121365

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