NANOGNB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of retinoic acid receptor signaling pathway (GO:0048387)8.76156484
2regulation of retinoic acid receptor signaling pathway (GO:0048385)7.51988907
3sphingosine metabolic process (GO:0006670)5.29432224
4piRNA metabolic process (GO:0034587)5.13130094
5diol metabolic process (GO:0034311)4.95009765
6sphingoid metabolic process (GO:0046519)4.80097052
7DNA methylation involved in gamete generation (GO:0043046)4.77055898
8behavioral response to nicotine (GO:0035095)4.43890151
9regulation of meiosis I (GO:0060631)4.43699066
10regulation of nuclear cell cycle DNA replication (GO:0033262)3.91815292
11somite rostral/caudal axis specification (GO:0032525)3.74433025
12DNA deamination (GO:0045006)3.71565111
13establishment of protein localization to mitochondrial membrane (GO:0090151)3.71259414
14male meiosis I (GO:0007141)3.45476228
15L-fucose catabolic process (GO:0042355)3.43579071
16fucose catabolic process (GO:0019317)3.43579071
17L-fucose metabolic process (GO:0042354)3.43579071
18positive regulation of meiosis (GO:0045836)3.42278811
19sulfate transmembrane transport (GO:1902358)3.37374815
20centriole replication (GO:0007099)3.35097948
21protein-cofactor linkage (GO:0018065)3.34718436
22reciprocal DNA recombination (GO:0035825)3.31135913
23reciprocal meiotic recombination (GO:0007131)3.31135913
24nonmotile primary cilium assembly (GO:0035058)3.30254035
25negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.26273578
26meiotic chromosome segregation (GO:0045132)3.25238908
27positive regulation of meiotic cell cycle (GO:0051446)3.24807617
28sulfate transport (GO:0008272)3.21342604
29heme transport (GO:0015886)3.14741391
30detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.14699984
31multicellular organism reproduction (GO:0032504)3.11438589
32chaperone-mediated protein transport (GO:0072321)3.08856749
33regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.02130769
34glycerophospholipid catabolic process (GO:0046475)3.00538704
35regulation of rhodopsin mediated signaling pathway (GO:0022400)2.97916252
36mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.94422685
37mitochondrial respiratory chain complex I assembly (GO:0032981)2.94422685
38NADH dehydrogenase complex assembly (GO:0010257)2.94422685
39tachykinin receptor signaling pathway (GO:0007217)2.94066869
40protein complex biogenesis (GO:0070271)2.93912255
41positive regulation of uterine smooth muscle contraction (GO:0070474)2.93034853
42indolalkylamine metabolic process (GO:0006586)2.90133681
43negative regulation of DNA-dependent DNA replication (GO:2000104)2.87625057
44lipopolysaccharide biosynthetic process (GO:0009103)2.86101271
45mitochondrial respiratory chain complex assembly (GO:0033108)2.81892617
46protein-chromophore linkage (GO:0018298)2.79827454
47protein polyglutamylation (GO:0018095)2.79365625
48nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.78346812
49exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.78310080
50rhodopsin mediated signaling pathway (GO:0016056)2.73530156
51RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.73467479
52tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.73467479
53ribonucleoprotein complex disassembly (GO:0032988)2.72621303
54organelle disassembly (GO:1903008)2.72141311
55meiosis I (GO:0007127)2.71008564
56peptidyl-histidine modification (GO:0018202)2.68720357
57tryptophan catabolic process (GO:0006569)2.66773317
58indole-containing compound catabolic process (GO:0042436)2.66773317
59indolalkylamine catabolic process (GO:0046218)2.66773317
60retinal cone cell development (GO:0046549)2.64743302
61sulfation (GO:0051923)2.64406315
62transcription from mitochondrial promoter (GO:0006390)2.63675302
63negative regulation of telomere maintenance (GO:0032205)2.63625473
64toxin metabolic process (GO:0009404)2.62957023
65negative regulation of cell cycle G2/M phase transition (GO:1902750)2.61875480
66ubiquinone biosynthetic process (GO:0006744)2.59198821
67iron coordination entity transport (GO:1901678)2.58214549
68pseudouridine synthesis (GO:0001522)2.57198484
69regulation of mesoderm development (GO:2000380)2.55558733
70embryonic axis specification (GO:0000578)2.54906076
71behavioral response to ethanol (GO:0048149)2.54497744
72adaptation of signaling pathway (GO:0023058)2.54192822
73recombinational repair (GO:0000725)2.54142451
74double-strand break repair via homologous recombination (GO:0000724)2.51879692
75phosphatidylinositol acyl-chain remodeling (GO:0036149)2.49119600
76meiotic cell cycle (GO:0051321)2.48939403
77tRNA processing (GO:0008033)2.48592969
78DNA replication checkpoint (GO:0000076)2.47529449
79G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.45469831
80epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.44987580
81mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.44858792
82replication fork processing (GO:0031297)2.44586137
83photoreceptor cell maintenance (GO:0045494)2.42935354
84epithelial cilium movement (GO:0003351)2.42362576
85male meiosis (GO:0007140)2.41789288
86platelet dense granule organization (GO:0060155)2.41145973
87chromatin remodeling at centromere (GO:0031055)2.40517932
88cell proliferation in forebrain (GO:0021846)2.40335026
89left/right axis specification (GO:0070986)2.39411720
90cornea development in camera-type eye (GO:0061303)2.38651805
91ubiquinone metabolic process (GO:0006743)2.38303877
92regulation of cilium movement (GO:0003352)2.38152662
93protein K6-linked ubiquitination (GO:0085020)2.37869630
94kynurenine metabolic process (GO:0070189)2.36001769
95notochord development (GO:0030903)2.35448942
96DNA double-strand break processing (GO:0000729)2.34952578
97negative regulation of transcription regulatory region DNA binding (GO:2000678)2.33518091
98water-soluble vitamin biosynthetic process (GO:0042364)2.32788074
99spermatid development (GO:0007286)2.31273659
100negative regulation of cytosolic calcium ion concentration (GO:0051481)2.30930036

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.25072162
2VDR_22108803_ChIP-Seq_LS180_Human3.14282807
3EZH2_22144423_ChIP-Seq_EOC_Human3.06329998
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.71628825
5IGF1R_20145208_ChIP-Seq_DFB_Human2.68573311
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.64874651
7NOTCH1_21737748_ChIP-Seq_TLL_Human2.55018525
8GBX2_23144817_ChIP-Seq_PC3_Human2.45256079
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.41111240
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.39104505
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.29378713
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.19541016
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.18558135
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.13783096
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.00996330
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.00478209
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00109346
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.97357303
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.95205593
20P300_19829295_ChIP-Seq_ESCs_Human1.90522719
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.75534844
22EST1_17652178_ChIP-ChIP_JURKAT_Human1.70951138
23AR_21572438_ChIP-Seq_LNCaP_Human1.68181192
24RBPJ_22232070_ChIP-Seq_NCS_Mouse1.66189403
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65561694
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.59311542
27TP63_19390658_ChIP-ChIP_HaCaT_Human1.57741106
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.57490920
29EWS_26573619_Chip-Seq_HEK293_Human1.57477233
30TP53_22573176_ChIP-Seq_HFKS_Human1.52486799
31ER_23166858_ChIP-Seq_MCF-7_Human1.52122380
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49905613
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.48839182
34POU5F1_16153702_ChIP-ChIP_HESCs_Human1.47909415
35ETS1_20019798_ChIP-Seq_JURKAT_Human1.46956524
36FUS_26573619_Chip-Seq_HEK293_Human1.44482564
37TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42950326
38POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42950326
39NANOG_19829295_ChIP-Seq_ESCs_Human1.42403143
40SOX2_19829295_ChIP-Seq_ESCs_Human1.42403143
41HOXB7_26014856_ChIP-Seq_BT474_Human1.38925733
42GATA3_21878914_ChIP-Seq_MCF-7_Human1.38761933
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38665648
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.36753820
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35326993
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34560531
47BCAT_22108803_ChIP-Seq_LS180_Human1.31052255
48MYC_18940864_ChIP-ChIP_HL60_Human1.30460733
49RNF2_27304074_Chip-Seq_NSC_Mouse1.30110410
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29803282
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.29725691
52NCOR_22424771_ChIP-Seq_293T_Human1.29112573
53AR_25329375_ChIP-Seq_VCAP_Human1.28807603
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28708546
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.26928492
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.26698998
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.26510087
58STAT3_23295773_ChIP-Seq_U87_Human1.25962422
59ETV2_25802403_ChIP-Seq_MESCs_Mouse1.25635327
60REST_21632747_ChIP-Seq_MESCs_Mouse1.25031732
61GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24458897
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.22473591
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.22473591
64TCF4_23295773_ChIP-Seq_U87_Human1.22047915
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.20352903
66SMAD4_21799915_ChIP-Seq_A2780_Human1.20241130
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17338827
68TCF4_22108803_ChIP-Seq_LS180_Human1.14224475
69EED_16625203_ChIP-ChIP_MESCs_Mouse1.14172284
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13716124
71VDR_23849224_ChIP-Seq_CD4+_Human1.13470877
72KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13274886
73FLI1_21867929_ChIP-Seq_TH2_Mouse1.12358511
74E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.12113513
75CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.11778354
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11575760
77LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11191079
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10613793
79EZH2_27304074_Chip-Seq_ESCs_Mouse1.09170321
80JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.08319424
81TAF15_26573619_Chip-Seq_HEK293_Human1.08046651
82EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07247775
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06249738
84CBP_20019798_ChIP-Seq_JUKART_Human1.06249738
85SMAD4_21741376_ChIP-Seq_EPCs_Human1.04438575
86CRX_20693478_ChIP-Seq_RETINA_Mouse1.03989671
87PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03873221
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.02220233
89CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.00697586
90AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99326700
91TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99150276
92PHF8_20622853_ChIP-Seq_HELA_Human0.98781147
93ELK1_19687146_ChIP-ChIP_HELA_Human0.98490531
94FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98049636
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97889430
96RUNX2_22187159_ChIP-Seq_PCA_Human0.97708347
97FOXH1_21741376_ChIP-Seq_ESCs_Human0.96744769
98ETV1_20927104_ChIP-Seq_GIST48_Human0.96459106
99KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96423405
100IRF1_19129219_ChIP-ChIP_H3396_Human0.96217492

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.97831347
2MP0003136_yellow_coat_color4.71590456
3MP0002653_abnormal_ependyma_morphology3.84843431
4MP0003646_muscle_fatigue3.27079163
5MP0005171_absent_coat_pigmentation3.08846223
6MP0003890_abnormal_embryonic-extraembry3.06520943
7MP0001986_abnormal_taste_sensitivity2.70513036
8MP0000569_abnormal_digit_pigmentation2.49936478
9MP0006292_abnormal_olfactory_placode2.43314940
10MP0005423_abnormal_somatic_nervous2.19534979
11MP0003195_calcinosis2.19417690
12MP0004147_increased_porphyrin_level2.13397489
13MP0004885_abnormal_endolymph2.08037167
14MP0002938_white_spotting2.07750477
15MP0002160_abnormal_reproductive_system2.00299612
16MP0008877_abnormal_DNA_methylation1.95967838
17MP0005551_abnormal_eye_electrophysiolog1.93765544
18MP0008875_abnormal_xenobiotic_pharmacok1.81624218
19MP0000427_abnormal_hair_cycle1.69279030
20MP0002102_abnormal_ear_morphology1.65989855
21MP0002254_reproductive_system_inflammat1.65729827
22MP0003787_abnormal_imprinting1.62311569
23MP0003045_fibrosis1.58560060
24MP0002095_abnormal_skin_pigmentation1.58243222
25MP0005646_abnormal_pituitary_gland1.56903164
26MP0004142_abnormal_muscle_tone1.56720371
27MP0001968_abnormal_touch/_nociception1.55122650
28MP0009745_abnormal_behavioral_response1.48658148
29MP0003718_maternal_effect1.47748085
30MP0004133_heterotaxia1.47303090
31MP0002876_abnormal_thyroid_physiology1.45721902
32MP0004043_abnormal_pH_regulation1.44729497
33MP0002277_abnormal_respiratory_mucosa1.44361789
34MP0005389_reproductive_system_phenotype1.41102608
35MP0002735_abnormal_chemical_nociception1.36764223
36MP0002736_abnormal_nociception_after1.36076252
37MP0002272_abnormal_nervous_system1.35574956
38MP0009046_muscle_twitch1.34428593
39MP0003879_abnormal_hair_cell1.32360253
40MP0006072_abnormal_retinal_apoptosis1.29899213
41MP0008789_abnormal_olfactory_epithelium1.25882569
42MP0005253_abnormal_eye_physiology1.25767311
43MP0001529_abnormal_vocalization1.23347417
44MP0001485_abnormal_pinna_reflex1.22309477
45MP0002138_abnormal_hepatobiliary_system1.22089314
46MP0003880_abnormal_central_pattern1.20274199
47MP0001486_abnormal_startle_reflex1.18982952
48MP0005085_abnormal_gallbladder_physiolo1.17908086
49MP0005174_abnormal_tail_pigmentation1.17590029
50MP0000778_abnormal_nervous_system1.16224282
51MP0006276_abnormal_autonomic_nervous1.13492818
52MP0003011_delayed_dark_adaptation1.13438471
53MP0001501_abnormal_sleep_pattern1.12958655
54MP0002210_abnormal_sex_determination1.12636426
55MP0008872_abnormal_physiological_respon1.11272841
56MP0002557_abnormal_social/conspecific_i1.08125329
57MP0004742_abnormal_vestibular_system1.07579775
58MP0003937_abnormal_limbs/digits/tail_de1.06489626
59MP0002572_abnormal_emotion/affect_behav1.06269144
60MP0005394_taste/olfaction_phenotype1.05450554
61MP0005499_abnormal_olfactory_system1.05450554
62MP0005075_abnormal_melanosome_morpholog1.03176291
63MP0001929_abnormal_gametogenesis1.02028539
64MP0003121_genomic_imprinting1.01177877
65MP0003137_abnormal_impulse_conducting1.00790481
66MP0003698_abnormal_male_reproductive1.00507360
67MP0000026_abnormal_inner_ear1.00236111
68MP0001984_abnormal_olfaction0.99791470
69MP0000631_abnormal_neuroendocrine_gland0.99583014
70MP0000647_abnormal_sebaceous_gland0.98274468
71MP0005395_other_phenotype0.95933653
72MP0001324_abnormal_eye_pigmentation0.94130413
73MP0005377_hearing/vestibular/ear_phenot0.94029719
74MP0003878_abnormal_ear_physiology0.94029719
75MP0001970_abnormal_pain_threshold0.92968908
76MP0002064_seizures0.91887323
77MP0005410_abnormal_fertilization0.87767027
78MP0008058_abnormal_DNA_repair0.86589744
79MP0002638_abnormal_pupillary_reflex0.86346736
80MP0005365_abnormal_bile_salt0.86343258
81MP0005195_abnormal_posterior_eye0.85755726
82MP0000653_abnormal_sex_gland0.84922807
83MP0002234_abnormal_pharynx_morphology0.84716577
84MP0001764_abnormal_homeostasis0.84106161
85MP0001145_abnormal_male_reproductive0.83397099
86MP0003119_abnormal_digestive_system0.82691047
87MP0001905_abnormal_dopamine_level0.81770965
88MP0002734_abnormal_mechanical_nocicepti0.81504224
89MP0009379_abnormal_foot_pigmentation0.81312488
90MP0004924_abnormal_behavior0.80356280
91MP0005386_behavior/neurological_phenoty0.80356280
92MP0001502_abnormal_circadian_rhythm0.80062203
93MP0002168_other_aberrant_phenotype0.79185701
94MP0000049_abnormal_middle_ear0.77683490
95MP0002163_abnormal_gland_morphology0.77029085
96MP0002067_abnormal_sensory_capabilities0.76376800
97MP0001963_abnormal_hearing_physiology0.74088167
98MP0001919_abnormal_reproductive_system0.73920410
99MP0002752_abnormal_somatic_nervous0.73626092
100MP0002733_abnormal_thermal_nociception0.72505115

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.45835184
2Molar tooth sign on MRI (HP:0002419)3.81548426
3Abnormality of midbrain morphology (HP:0002418)3.81548426
4Focal motor seizures (HP:0011153)3.71147268
5Amelogenesis imperfecta (HP:0000705)3.61061831
6Pendular nystagmus (HP:0012043)3.54433817
7Pancreatic fibrosis (HP:0100732)3.46607202
8Congenital stationary night blindness (HP:0007642)3.37966231
9True hermaphroditism (HP:0010459)3.33829439
10Nephronophthisis (HP:0000090)3.24157264
11Hyperalaninemia (HP:0003348)3.06141342
12Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.06141342
13Abnormality of alanine metabolism (HP:0010916)3.06141342
14Abnormality of the renal cortex (HP:0011035)3.02830542
15Abnormality of the renal medulla (HP:0100957)2.96066204
16Progressive inability to walk (HP:0002505)2.86735459
17Medial flaring of the eyebrow (HP:0010747)2.83534630
18Type II lissencephaly (HP:0007260)2.66475037
19Parakeratosis (HP:0001036)2.66002127
20Colon cancer (HP:0003003)2.62960584
21Tubular atrophy (HP:0000092)2.61615812
22Aplasia/Hypoplasia of the uvula (HP:0010293)2.59337165
23Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.50774943
24Inability to walk (HP:0002540)2.49028244
25Gait imbalance (HP:0002141)2.41679295
26Abnormal drinking behavior (HP:0030082)2.34980653
27Polydipsia (HP:0001959)2.34980653
28Acute necrotizing encephalopathy (HP:0006965)2.34710523
29Congenital primary aphakia (HP:0007707)2.33285068
30Cystic liver disease (HP:0006706)2.30847660
31Attenuation of retinal blood vessels (HP:0007843)2.27833654
323-Methylglutaconic aciduria (HP:0003535)2.25324130
33Increased CSF lactate (HP:0002490)2.24721312
34Anencephaly (HP:0002323)2.19921708
35Increased hepatocellular lipid droplets (HP:0006565)2.17423286
36Aplasia/hypoplasia of the uterus (HP:0008684)2.16167765
37Birth length less than 3rd percentile (HP:0003561)2.15756266
38Mitochondrial inheritance (HP:0001427)2.14460622
39Nephrogenic diabetes insipidus (HP:0009806)2.14022816
40Lipid accumulation in hepatocytes (HP:0006561)2.13619385
41Oligodactyly (hands) (HP:0001180)2.12369255
42Decreased circulating renin level (HP:0003351)2.12147140
43Cerebellar dysplasia (HP:0007033)2.10806182
44Dialeptic seizures (HP:0011146)2.10119966
45Sclerocornea (HP:0000647)2.09843829
46Abnormal rod and cone electroretinograms (HP:0008323)2.07326912
47Acute encephalopathy (HP:0006846)2.06842882
48Abnormal mitochondria in muscle tissue (HP:0008316)2.04790694
49Aplastic anemia (HP:0001915)2.01628187
50Glycosuria (HP:0003076)2.01250500
51Abnormality of urine glucose concentration (HP:0011016)2.01250500
52Chronic hepatic failure (HP:0100626)1.98948149
53Progressive macrocephaly (HP:0004481)1.98460029
54Aplasia/Hypoplasia of the tibia (HP:0005772)1.97869993
55Patellar aplasia (HP:0006443)1.97589013
56Polyuria (HP:0000103)1.97541307
57Male pseudohermaphroditism (HP:0000037)1.97470959
58Absent rod-and cone-mediated responses on ERG (HP:0007688)1.97460204
59Optic disc pallor (HP:0000543)1.96027694
60Genital tract atresia (HP:0001827)1.95712887
61Abnormal pancreas size (HP:0012094)1.93093946
62Vaginal atresia (HP:0000148)1.92731968
63Congenital malformation of the right heart (HP:0011723)1.92420907
64Double outlet right ventricle (HP:0001719)1.92420907
65Aplasia/Hypoplasia of the patella (HP:0006498)1.92358786
66Furrowed tongue (HP:0000221)1.90664263
67Dynein arm defect of respiratory motile cilia (HP:0012255)1.87747873
68Absent/shortened dynein arms (HP:0200106)1.87747873
69Renal Fanconi syndrome (HP:0001994)1.87585931
70Retinitis pigmentosa (HP:0000510)1.87109582
71Focal seizures (HP:0007359)1.86694611
72Concave nail (HP:0001598)1.84059317
73Abnormal number of erythroid precursors (HP:0012131)1.83995646
74Supernumerary spleens (HP:0009799)1.83139062
75Hyperventilation (HP:0002883)1.82943943
76Abolished electroretinogram (ERG) (HP:0000550)1.80613033
77Congenital hepatic fibrosis (HP:0002612)1.79096117
78Increased serum lactate (HP:0002151)1.77821248
79Constricted visual fields (HP:0001133)1.77575544
80Chorioretinal atrophy (HP:0000533)1.76799102
81Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74776488
82Aplasia/Hypoplasia of the tongue (HP:0010295)1.72952877
83Bony spicule pigmentary retinopathy (HP:0007737)1.72900611
84Hypoplasia of the pons (HP:0012110)1.72325447
85Abnormality of the ileum (HP:0001549)1.71706525
86Increased corneal curvature (HP:0100692)1.71658827
87Keratoconus (HP:0000563)1.71658827
88Meckel diverticulum (HP:0002245)1.70940023
89Ectopic kidney (HP:0000086)1.70753122
90Aplasia/Hypoplasia of the fovea (HP:0008060)1.70480374
91Hypoplasia of the fovea (HP:0007750)1.70480374
92Ulnar claw (HP:0001178)1.69039559
93Poor coordination (HP:0002370)1.68120051
94Anophthalmia (HP:0000528)1.67683854
95Septo-optic dysplasia (HP:0100842)1.67182982
96Abnormality of the labia minora (HP:0012880)1.67077364
97Congenital, generalized hypertrichosis (HP:0004540)1.66725010
98Tubulointerstitial fibrosis (HP:0005576)1.65381678
99Postaxial foot polydactyly (HP:0001830)1.64771961
100Abnormality of cells of the erythroid lineage (HP:0012130)1.63156088

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS15.07252710
2FRK4.44373653
3STK38L3.63168709
4ZAK3.44002817
5ACVR1B2.86601818
6PNCK2.84064434
7LATS22.76978067
8BMPR1B2.76291507
9WNK32.45425987
10TLK12.40682230
11ADRBK22.27356116
12WNK42.18074739
13GRK12.15232966
14INSRR1.87176455
15NLK1.77087472
16PINK11.71957473
17NUAK11.70029869
18WEE11.55026656
19STK391.51600258
20TAOK31.47918951
21MAP4K21.47287178
22NEK21.33537327
23OXSR11.30742649
24TIE11.29183763
25STK31.22094438
26MAPK131.15981580
27TNIK1.15892008
28MAP3K91.13416840
29MAP2K21.12579059
30PRKD31.08037859
31DYRK21.05374446
32EPHB21.04473022
33MAP3K41.01554540
34EPHA41.01161591
35MARK11.01116483
36TRIM281.00324217
37MKNK20.98719811
38PLK30.96396169
39PLK40.94207740
40MELK0.93356353
41STK380.93003731
42TGFBR10.91378232
43PRKCG0.90986446
44ADRBK10.89962947
45PLK10.89342955
46DAPK20.89027937
47PDK20.85982152
48TAF10.85576034
49EIF2AK30.77653731
50TTK0.77557788
51NEK10.75686072
52BRSK20.74866990
53CHEK20.72825616
54VRK10.69263396
55PRKAA20.67973586
56AKT30.66637012
57PRKCE0.64841413
58CASK0.61468114
59SRPK10.60307599
60NME10.59748525
61BUB10.58238124
62NTRK30.56163451
63CDC70.52745662
64PLK20.49929569
65PHKG20.49862010
66PHKG10.49862010
67NTRK20.49765362
68PTK2B0.49535582
69VRK20.48344055
70CSNK1A1L0.48043691
71STK160.47274175
72LIMK10.45377748
73MAP2K70.44387094
74CDK190.44360776
75MKNK10.43859168
76TNK20.43135403
77DYRK30.41275518
78PIM10.40924097
79PRKACA0.40214296
80STK110.40054080
81ATR0.39827844
82PRKCI0.38517177
83CAMK2A0.38442804
84TXK0.37140518
85GRK70.35992613
86TEC0.35903401
87GRK50.35055099
88PAK30.34342078
89CSNK2A10.34303012
90MAPK150.32150308
91PIK3CG0.32070867
92PKN10.30041514
93PRKCZ0.27876151
94CDK30.27400689
95AURKA0.27009716
96PRKACB0.25637536
97CSNK1D0.24552664
98CSNK1G20.23960086
99CSNK1A10.23365772
100ATM0.22984703

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.38660931
2Phototransduction_Homo sapiens_hsa047443.21214032
3Basal transcription factors_Homo sapiens_hsa030222.52721211
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.37953104
5Oxidative phosphorylation_Homo sapiens_hsa001902.37639248
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.25626898
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.24493730
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.21987406
9Ribosome_Homo sapiens_hsa030102.20686332
10Nitrogen metabolism_Homo sapiens_hsa009102.11605772
11Protein export_Homo sapiens_hsa030602.09769536
12Nicotine addiction_Homo sapiens_hsa050332.08261805
13Linoleic acid metabolism_Homo sapiens_hsa005912.03253530
14Homologous recombination_Homo sapiens_hsa034401.93407818
15Parkinsons disease_Homo sapiens_hsa050121.91342158
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.90854978
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88513090
18Caffeine metabolism_Homo sapiens_hsa002321.82389638
19Fanconi anemia pathway_Homo sapiens_hsa034601.81125655
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.77506971
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.77374445
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.75769304
23RNA polymerase_Homo sapiens_hsa030201.75010536
24Butanoate metabolism_Homo sapiens_hsa006501.65704236
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.62407342
26Taste transduction_Homo sapiens_hsa047421.58995016
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.53990246
28Dorso-ventral axis formation_Homo sapiens_hsa043201.52228683
29Huntingtons disease_Homo sapiens_hsa050161.49528581
30Tryptophan metabolism_Homo sapiens_hsa003801.47944703
31Regulation of autophagy_Homo sapiens_hsa041401.46538610
32One carbon pool by folate_Homo sapiens_hsa006701.45370695
33Selenocompound metabolism_Homo sapiens_hsa004501.40475398
34Morphine addiction_Homo sapiens_hsa050321.32081020
35Propanoate metabolism_Homo sapiens_hsa006401.30835666
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.26941239
37Sulfur relay system_Homo sapiens_hsa041221.26380264
38Ether lipid metabolism_Homo sapiens_hsa005651.21525011
39RNA degradation_Homo sapiens_hsa030181.16670659
40Sphingolipid metabolism_Homo sapiens_hsa006001.15959927
41Folate biosynthesis_Homo sapiens_hsa007901.13579183
42Cardiac muscle contraction_Homo sapiens_hsa042601.12221776
43Ovarian steroidogenesis_Homo sapiens_hsa049131.11908543
44Steroid biosynthesis_Homo sapiens_hsa001001.09867890
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.06547607
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.06506626
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.05407760
48Alzheimers disease_Homo sapiens_hsa050101.05234041
49GABAergic synapse_Homo sapiens_hsa047270.99116466
50Basal cell carcinoma_Homo sapiens_hsa052170.96096438
51Collecting duct acid secretion_Homo sapiens_hsa049660.88585332
52Serotonergic synapse_Homo sapiens_hsa047260.85977844
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81717886
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79595922
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.78448153
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78415305
57Olfactory transduction_Homo sapiens_hsa047400.76790554
58Glutamatergic synapse_Homo sapiens_hsa047240.76474928
59Insulin secretion_Homo sapiens_hsa049110.76416535
60Peroxisome_Homo sapiens_hsa041460.76222084
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75785820
62Chemical carcinogenesis_Homo sapiens_hsa052040.75243572
63Hedgehog signaling pathway_Homo sapiens_hsa043400.72736183
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71320250
65Mismatch repair_Homo sapiens_hsa034300.70192013
66ABC transporters_Homo sapiens_hsa020100.69125979
67Purine metabolism_Homo sapiens_hsa002300.66888417
68RNA transport_Homo sapiens_hsa030130.66755632
69Metabolic pathways_Homo sapiens_hsa011000.66234586
70Arachidonic acid metabolism_Homo sapiens_hsa005900.65990451
71Pyrimidine metabolism_Homo sapiens_hsa002400.65031093
72Proteasome_Homo sapiens_hsa030500.64350563
73Calcium signaling pathway_Homo sapiens_hsa040200.63186872
74Histidine metabolism_Homo sapiens_hsa003400.63098588
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57902204
76beta-Alanine metabolism_Homo sapiens_hsa004100.57018655
77Retinol metabolism_Homo sapiens_hsa008300.53097786
78Circadian entrainment_Homo sapiens_hsa047130.50287792
79Hippo signaling pathway_Homo sapiens_hsa043900.48695594
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48229925
81Nucleotide excision repair_Homo sapiens_hsa034200.47832614
82Arginine and proline metabolism_Homo sapiens_hsa003300.42588845
83Vitamin digestion and absorption_Homo sapiens_hsa049770.40186677
84Spliceosome_Homo sapiens_hsa030400.38937605
85p53 signaling pathway_Homo sapiens_hsa041150.38897464
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35048911
87Non-homologous end-joining_Homo sapiens_hsa034500.34980939
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34855527
89Glycerolipid metabolism_Homo sapiens_hsa005610.34787187
90Oocyte meiosis_Homo sapiens_hsa041140.33381338
91Mineral absorption_Homo sapiens_hsa049780.32893092
92Fat digestion and absorption_Homo sapiens_hsa049750.31999117
93Wnt signaling pathway_Homo sapiens_hsa043100.31117891
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30910548
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.29170857
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29072277
97Cell cycle_Homo sapiens_hsa041100.28488913
98Pyruvate metabolism_Homo sapiens_hsa006200.27595759
99Fatty acid biosynthesis_Homo sapiens_hsa000610.27409432
100Bile secretion_Homo sapiens_hsa049760.27178504

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