NAMPTP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.65106943
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.65106943
3positive regulation by organism of defense response of other organism involved in symbiotic interact5.65106943
4modulation by symbiont of host immune response (GO:0052553)5.65106943
5positive regulation by symbiont of host defense response (GO:0052509)5.65106943
6modulation by symbiont of host defense response (GO:0052031)5.65106943
7response to peptidoglycan (GO:0032494)5.43856823
8positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)5.33324746
9negative regulation of interleukin-12 production (GO:0032695)5.32049295
10negative regulation of cell killing (GO:0031342)5.26749312
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.26749312
12detection of molecule of bacterial origin (GO:0032490)5.26366529
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.13474562
14macrophage activation involved in immune response (GO:0002281)4.93845444
15positive regulation of gamma-delta T cell activation (GO:0046645)4.92792125
16neutrophil activation involved in immune response (GO:0002283)4.72317118
17detection of other organism (GO:0098543)4.67476535
18cellular extravasation (GO:0045123)4.52815197
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.38207648
20detection of external biotic stimulus (GO:0098581)4.38091456
21regulation of interferon-beta biosynthetic process (GO:0045357)4.25971195
22neutrophil activation (GO:0042119)4.25384970
23leukocyte aggregation (GO:0070486)4.23034728
24detection of bacterium (GO:0016045)4.16462792
25antigen processing and presentation of endogenous antigen (GO:0019883)4.14675682
26granulocyte activation (GO:0036230)4.06088879
27antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.01508048
28immunoglobulin mediated immune response (GO:0016064)4.00721982
29detection of biotic stimulus (GO:0009595)3.98084735
30neutrophil mediated immunity (GO:0002446)3.95344729
31regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.93789304
32lipopolysaccharide-mediated signaling pathway (GO:0031663)3.92864365
33microglial cell activation (GO:0001774)3.89433781
34respiratory burst (GO:0045730)3.85735989
35macrophage activation (GO:0042116)3.84550866
36type I interferon signaling pathway (GO:0060337)3.83636617
37cellular response to type I interferon (GO:0071357)3.83636617
38response to host immune response (GO:0052572)3.82546473
39response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.82546473
40production of molecular mediator involved in inflammatory response (GO:0002532)3.79484010
41response to type I interferon (GO:0034340)3.77751386
42regulation of B cell receptor signaling pathway (GO:0050855)3.76971610
43leukocyte migration involved in inflammatory response (GO:0002523)3.76940355
44regulation of gamma-delta T cell activation (GO:0046643)3.71095681
45response to interleukin-15 (GO:0070672)3.68727198
46germinal center formation (GO:0002467)3.63571064
47negative regulation of lymphocyte mediated immunity (GO:0002707)3.59997175
48T-helper 1 type immune response (GO:0042088)3.53574374
49interferon-gamma-mediated signaling pathway (GO:0060333)3.49894131
50defense response to protozoan (GO:0042832)3.49691806
51myeloid cell activation involved in immune response (GO:0002275)3.47285727
52cellular response to interleukin-15 (GO:0071350)3.43945519
53response to host (GO:0075136)3.43898076
54response to host defenses (GO:0052200)3.43898076
55response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.43898076
56negative regulation of T cell mediated immunity (GO:0002710)3.37862077
57positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.37448854
58regulation of interferon-alpha production (GO:0032647)3.37320197
59positive regulation of interferon-alpha production (GO:0032727)3.36651866
60regulation of T cell tolerance induction (GO:0002664)3.35720451
61positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.35296488
62B cell mediated immunity (GO:0019724)3.32068839
63positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.31715749
64myeloid leukocyte mediated immunity (GO:0002444)3.30535720
65positive regulation of NF-kappaB import into nucleus (GO:0042346)3.29695371
66negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.29583812
67regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.27592793
68regulation of tolerance induction (GO:0002643)3.27005506
69neutrophil chemotaxis (GO:0030593)3.23250074
70response to protozoan (GO:0001562)3.21292724
71regulation of dendritic cell antigen processing and presentation (GO:0002604)3.20191111
72positive regulation of toll-like receptor signaling pathway (GO:0034123)3.19126563
73regulation of T-helper 2 cell differentiation (GO:0045628)3.19003160
74positive regulation of type 2 immune response (GO:0002830)3.17232972
75neutrophil migration (GO:1990266)3.14881208
76negative regulation of leukocyte mediated immunity (GO:0002704)3.12346025
77positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.10984144
78response to muramyl dipeptide (GO:0032495)3.10280062
79negative regulation of cytokine production involved in immune response (GO:0002719)3.10161347
80regulation of mast cell degranulation (GO:0043304)3.08240093
81regulation of interleukin-8 biosynthetic process (GO:0045414)3.07286650
82negative regulation of T-helper cell differentiation (GO:0045623)3.07267754
83negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.07267754
84regulation of mast cell activation (GO:0033003)3.04875427
85positive regulation of mast cell activation (GO:0033005)3.03657486
86positive regulation of interleukin-1 beta secretion (GO:0050718)3.03138525
87response to interferon-alpha (GO:0035455)3.01648039
88positive regulation of acute inflammatory response (GO:0002675)3.00354411
89myeloid leukocyte activation (GO:0002274)2.99590689
90positive regulation of interleukin-10 production (GO:0032733)2.97974351
91regulation of interleukin-12 production (GO:0032655)2.97951740
92regulation of T cell mediated cytotoxicity (GO:0001914)2.96834786
93regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.95615981
94regulation of interleukin-6 biosynthetic process (GO:0045408)2.93637083
95positive regulation of interferon-beta production (GO:0032728)2.93007792
96regulation of regulatory T cell differentiation (GO:0045589)2.91415197
97positive regulation of T cell mediated cytotoxicity (GO:0001916)2.88626859
98cytokine secretion (GO:0050663)2.87353778
99positive regulation of tolerance induction (GO:0002645)2.87096115
100positive regulation of interleukin-1 secretion (GO:0050716)2.84813920

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.69322100
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.91530359
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.98649772
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.62805285
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.00527145
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.71289750
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.64807711
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.54865009
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.50110369
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.32796345
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.25242621
12MYB_21317192_ChIP-Seq_ERMYB_Mouse3.20242499
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.12015642
14RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.03856652
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.80769354
16SPI1_23547873_ChIP-Seq_NB4_Human2.78158641
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.61124368
18Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.59152155
19RUNX_20019798_ChIP-Seq_JUKART_Human2.58243215
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.57578877
21MYB_26560356_Chip-Seq_TH2_Human2.30882960
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.24399953
23EGR1_19374776_ChIP-ChIP_THP-1_Human2.21161938
24VDR_24763502_ChIP-Seq_THP-1_Human2.12848146
25SPI1_23127762_ChIP-Seq_K562_Human2.12044506
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.10860617
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.04866083
28BRD4_27068464_Chip-Seq_AML-cells_Mouse2.01315152
29VDR_24787735_ChIP-Seq_THP-1_Human2.00233253
30MAF_26560356_Chip-Seq_TH1_Human1.92418258
31MYB_26560356_Chip-Seq_TH1_Human1.88706598
32FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.86309492
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.85987517
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.74719318
35NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.74211483
36CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.66093144
37GATA3_26560356_Chip-Seq_TH2_Human1.65610119
38STAT6_21828071_ChIP-Seq_BEAS2B_Human1.60142650
39GATA3_27048872_Chip-Seq_THYMUS_Human1.58901985
40PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.58728114
41PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.58076510
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.57392321
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.54328645
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.51467017
45UTX_26944678_Chip-Seq_JUKART_Human1.51137199
46GATA1_22025678_ChIP-Seq_K562_Human1.51121549
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50876410
48PU_27001747_Chip-Seq_BMDM_Mouse1.50392332
49SCL_19346495_ChIP-Seq_HPC-7_Human1.49603802
50VDR_21846776_ChIP-Seq_THP-1_Human1.48414678
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48380079
52LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.42034837
53CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35519673
54CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30804510
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.27446127
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.27172606
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26865027
58LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.25999663
59GATA2_21666600_ChIP-Seq_HMVEC_Human1.25521222
60CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24428754
61STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.22136704
62SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19900699
63MAF_26560356_Chip-Seq_TH2_Human1.17831986
64PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17784060
65NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.10419032
66TCF7_22412390_ChIP-Seq_EML_Mouse1.10404787
67VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10112609
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09719758
69TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09679867
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05529643
71GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03774714
72PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00836171
73HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97970510
74EGR1_19032775_ChIP-ChIP_M12_Human0.93775578
75BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.93540867
76RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.91809862
77GATA1_19941827_ChIP-Seq_MEL_Mouse0.86271994
78MYC_22102868_ChIP-Seq_BL_Human0.85497088
79VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.84374539
80GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84318881
81GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82146887
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80843663
83KDM2B_26808549_Chip-Seq_SUP-B15_Human0.80216117
84TFEB_21752829_ChIP-Seq_HELA_Human0.78239576
85PU.1_20513432_ChIP-Seq_Bcells_Mouse0.77104798
86ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.74920309
87SMRT_27268052_Chip-Seq_Bcells_Human0.74263599
88CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.72409049
89KDM2B_26808549_Chip-Seq_DND41_Human0.70306072
90TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.70297886
91JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.70006200
92CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.69636646
93STAT1_20625510_ChIP-Seq_HELA_Human0.69478747
94KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.67669897
95EGR1_23403033_ChIP-Seq_LIVER_Mouse0.67225217
96FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.65157847
97CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.63691584
98GATA3_26560356_Chip-Seq_TH1_Human0.62781066
99ELK3_25401928_ChIP-Seq_HUVEC_Human0.61519884
100KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.60394170

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.57306384
2MP0003303_peritoneal_inflammation4.66981778
3MP0003436_decreased_susceptibility_to4.20474858
4MP0001835_abnormal_antigen_presentation3.70921333
5MP0009785_altered_susceptibility_to3.53916863
6MP0002419_abnormal_innate_immunity3.06198958
7MP0002148_abnormal_hypersensitivity_rea3.00512820
8MP0005000_abnormal_immune_tolerance2.95651787
9MP0005671_abnormal_response_to2.89104891
10MP0005025_abnormal_response_to2.84023265
11MP0006082_CNS_inflammation2.81804697
12MP0001790_abnormal_immune_system2.81195836
13MP0005387_immune_system_phenotype2.81195836
14MP0001800_abnormal_humoral_immune2.74820092
15MP0000685_abnormal_immune_system2.62238202
16MP0002723_abnormal_immune_serum2.58924214
17MP0002452_abnormal_antigen_presenting2.50205895
18MP0009764_decreased_sensitivity_to2.42606086
19MP0003300_gastrointestinal_ulcer2.35773807
20MP0002420_abnormal_adaptive_immunity2.31735366
21MP0001819_abnormal_immune_cell2.30297015
22MP0001533_abnormal_skeleton_physiology2.30009397
23MP0002405_respiratory_system_inflammati2.00703100
24MP0001845_abnormal_inflammatory_respons1.92233223
25MP0010155_abnormal_intestine_physiology1.90524916
26MP0004510_myositis1.88398665
27MP0004947_skin_inflammation1.82471398
28MP0003075_altered_response_to1.82063628
29MP0009278_abnormal_bone_marrow1.77359262
30MP0002277_abnormal_respiratory_mucosa1.74787046
31MP0003191_abnormal_cellular_cholesterol1.71679416
32MP0005451_abnormal_body_composition1.66905533
33MP0008004_abnormal_stomach_pH1.66278035
34MP0000716_abnormal_immune_system1.65694992
35MP0008469_abnormal_protein_level1.64871483
36MP0003828_pulmonary_edema1.58320108
37MP0002398_abnormal_bone_marrow1.58070300
38MP0005464_abnormal_platelet_physiology1.57764545
39MP0001853_heart_inflammation1.55627829
40MP0009333_abnormal_splenocyte_physiolog1.55419763
41MP0008260_abnormal_autophagy1.50171916
42MP0002132_abnormal_respiratory_system1.45861704
43MP0000343_altered_response_to1.44198140
44MP0003763_abnormal_thymus_physiology1.40190509
45MP0000465_gastrointestinal_hemorrhage1.38452569
46MP0005166_decreased_susceptibility_to1.38036718
47MP0005164_abnormal_response_to1.35855221
48MP0003806_abnormal_nucleotide_metabolis1.35719462
49MP0000689_abnormal_spleen_morphology1.32927184
50MP0003448_altered_tumor_morphology1.32157679
51MP0002722_abnormal_immune_system1.31621576
52MP0000858_altered_metastatic_potential1.29883762
53MP0002429_abnormal_blood_cell1.29045768
54MP0002332_abnormal_exercise_endurance1.26621861
55MP0005397_hematopoietic_system_phenotyp1.26139480
56MP0001545_abnormal_hematopoietic_system1.26139480
57MP0002998_abnormal_bone_remodeling1.24264528
58MP0005310_abnormal_salivary_gland1.19723915
59MP0005167_abnormal_blood-brain_barrier1.17840760
60MP0003866_abnormal_defecation1.13884263
61MP0004883_abnormal_blood_vessel1.08427498
62MP0009763_increased_sensitivity_to1.04282363
63MP0003172_abnormal_lysosome_physiology1.02690548
64MP0003656_abnormal_erythrocyte_physiolo1.02423976
65MP0002254_reproductive_system_inflammat1.01688761
66MP0009765_abnormal_xenobiotic_induced1.01681423
67MP0006054_spinal_hemorrhage1.00839033
68MP0002006_tumorigenesis0.99389915
69MP0003183_abnormal_peptide_metabolism0.98980430
70MP0003221_abnormal_cardiomyocyte_apopto0.98266239
71MP0003195_calcinosis0.97668910
72MP0000703_abnormal_thymus_morphology0.96130805
73MP0001851_eye_inflammation0.94983514
74MP0005390_skeleton_phenotype0.94516358
75MP0003045_fibrosis0.93220947
76MP0009840_abnormal_foam_cell0.88448105
77MP0002166_altered_tumor_susceptibility0.88038956
78MP0001663_abnormal_digestive_system0.82440485
79MP0000604_amyloidosis0.82323898
80MP0002138_abnormal_hepatobiliary_system0.81573650
81MP0003690_abnormal_glial_cell0.77117084
82MP0001873_stomach_inflammation0.71612508
83MP0005058_abnormal_lysosome_morphology0.69757338
84MP0010352_gastrointestinal_tract_polyps0.69628759
85MP0004381_abnormal_hair_follicle0.68055319
86MP0000249_abnormal_blood_vessel0.67051830
87MP0002933_joint_inflammation0.65612739
88MP0005319_abnormal_enzyme/_coenzyme0.63350698
89MP0002396_abnormal_hematopoietic_system0.63254351
90MP0004808_abnormal_hematopoietic_stem0.62968989
91MP0003795_abnormal_bone_structure0.62298788
92MP0008873_increased_physiological_sensi0.61473388
93MP0003453_abnormal_keratinocyte_physiol0.61466409
94MP0004484_altered_response_of0.58337965
95MP0008874_decreased_physiological_sensi0.53129087
96MP0002693_abnormal_pancreas_physiology0.53100711
97MP0005535_abnormal_body_temperature0.52238047
98MP0000609_abnormal_liver_physiology0.52080755
99MP0005376_homeostasis/metabolism_phenot0.50289075
100MP0000490_abnormal_crypts_of0.46917925

Predicted human phenotypes

RankGene SetZ-score
1Orchitis (HP:0100796)6.86806442
2Retrobulbar optic neuritis (HP:0100654)6.77286047
3Optic neuritis (HP:0100653)6.77286047
4Myositis (HP:0100614)6.53876348
5Stomatitis (HP:0010280)6.34111251
6Eczematoid dermatitis (HP:0000976)6.00931373
7Recurrent bacterial skin infections (HP:0005406)5.79191814
8Abnormality of macrophages (HP:0004311)5.63959729
9Recurrent abscess formation (HP:0002722)5.60516971
10Elevated erythrocyte sedimentation rate (HP:0003565)5.24200517
11Keratoconjunctivitis sicca (HP:0001097)4.84012557
12Recurrent gram-negative bacterial infections (HP:0005420)4.71804604
13Keratoconjunctivitis (HP:0001096)4.52548844
14Mediastinal lymphadenopathy (HP:0100721)4.46687235
15Gastrointestinal infarctions (HP:0005244)4.44674410
16Vasculitis (HP:0002633)3.93089067
17Recurrent fungal infections (HP:0002841)3.92487515
18Recurrent skin infections (HP:0001581)3.80382931
19Encephalitis (HP:0002383)3.79496106
20Meningitis (HP:0001287)3.67089272
21Obstructive lung disease (HP:0006536)3.61817245
22Chronic obstructive pulmonary disease (HP:0006510)3.61817245
23Pulmonary infiltrates (HP:0002113)3.60562956
24Hemoptysis (HP:0002105)3.57169659
25Gangrene (HP:0100758)3.46343036
26Abnormal delayed hypersensitivity skin test (HP:0002963)3.42606398
27Anorexia (HP:0002039)3.42242697
28Urticaria (HP:0001025)3.40300441
29T lymphocytopenia (HP:0005403)3.38093339
30Episodic fever (HP:0001954)3.36441982
31Arterial thrombosis (HP:0004420)3.36397260
32Increased IgM level (HP:0003496)3.34754872
33Abnormality of T cell number (HP:0011839)3.31225187
34Recurrent cutaneous fungal infections (HP:0011370)3.28885000
35Chronic mucocutaneous candidiasis (HP:0002728)3.28885000
36Amyloidosis (HP:0011034)3.13051664
37Gingivitis (HP:0000230)3.11314598
38Chest pain (HP:0100749)3.11143651
39Leukocytosis (HP:0001974)3.01568059
40Peritonitis (HP:0002586)2.94889487
41Spontaneous hematomas (HP:0007420)2.84427851
42Increased IgE level (HP:0003212)2.83569254
43Abnormality of the pleura (HP:0002103)2.82202398
44Pulmonary embolism (HP:0002204)2.78850422
45Abnormality of T cells (HP:0002843)2.71161151
46Recurrent viral infections (HP:0004429)2.64752912
47Abnormality of glycolipid metabolism (HP:0010969)2.56794799
48Abnormality of liposaccharide metabolism (HP:0010968)2.56794799
49Abnormality of glycosphingolipid metabolism (HP:0004343)2.56794799
50Keratitis (HP:0000491)2.52776308
51Autoimmune hemolytic anemia (HP:0001890)2.46465703
52Glomerulopathy (HP:0100820)2.46118718
53Polyneuropathy (HP:0001271)2.42927446
54Abnormality of the endocardium (HP:0004306)2.41865782
55Gingival bleeding (HP:0000225)2.40593738
56Petechiae (HP:0000967)2.36195064
57Autoimmune thrombocytopenia (HP:0001973)2.34721543
58Cellulitis (HP:0100658)2.34586565
59Abnormality of T cell physiology (HP:0011840)2.30993923
60Pustule (HP:0200039)2.29591972
61Hypergammaglobulinemia (HP:0010702)2.29535677
62Premature loss of primary teeth (HP:0006323)2.29100839
63Abnormality of the pericardium (HP:0001697)2.28430118
64Vertigo (HP:0002321)2.27037888
65Loss of speech (HP:0002371)2.24920696
66Granulocytopenia (HP:0001913)2.22030294
67Abnormality of the peritoneum (HP:0002585)2.20603865
68Recurrent bronchitis (HP:0002837)2.19873666
69Eosinophilia (HP:0001880)2.19253088
70Osteomyelitis (HP:0002754)2.18986218
71Prolonged bleeding time (HP:0003010)2.17728078
72Acne (HP:0001061)2.16470774
73Lymphopenia (HP:0001888)2.13031001
74Acute hepatic failure (HP:0006554)2.12692123
75Increased serum ferritin (HP:0003281)2.11064176
76Sepsis (HP:0100806)2.10965998
77Epistaxis (HP:0000421)2.09512327
78Disinhibition (HP:0000734)2.08152184
79Joint swelling (HP:0001386)2.07768755
80Hypochromic microcytic anemia (HP:0004840)2.07635158
81Hypochromic anemia (HP:0001931)2.05769941
82Amaurosis fugax (HP:0100576)2.03938411
83Abnormality of cells of the lymphoid lineage (HP:0012140)2.02865976
84Hepatosplenomegaly (HP:0001433)2.01038407
85Chronic otitis media (HP:0000389)1.99442357
86Arthralgia (HP:0002829)1.92979498
87Thrombophlebitis (HP:0004418)1.92842150
88Vacuolated lymphocytes (HP:0001922)1.92170732
89Inflammation of the large intestine (HP:0002037)1.92128479
90Alveolar cell carcinoma (HP:0006519)1.92091404
91Neoplasm of the tracheobronchial system (HP:0100552)1.89654895
92IgG deficiency (HP:0004315)1.89260877
93Abnormality of eosinophils (HP:0001879)1.89184026
94Subacute progressive viral hepatitis (HP:0006572)1.88730098
95Increased cerebral lipofuscin (HP:0011813)1.88644792
96Abnormality of iron homeostasis (HP:0011031)1.88474862
97Hematochezia (HP:0002573)1.87754612
98Skin ulcer (HP:0200042)1.87250421
99Segmental peripheral demyelination/remyelination (HP:0003481)1.84947297
100Skin rash (HP:0000988)1.83217368

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.25569198
2IRAK43.97313774
3MAP4K13.25706557
4BLK3.23556167
5IRAK32.96514835
6TYK22.96206969
7CSK2.93623225
8MAP3K142.91733710
9TXK2.87902942
10MAP2K32.54022296
11IKBKE2.26700483
12SIK32.23207506
13ZAP702.08663084
14JAK32.07267993
15MAP3K32.06654949
16ERN12.05066152
17TBK11.98550134
18FGR1.92264418
19BMPR21.86963010
20IRAK11.86818430
21MATK1.85950304
22EPHB11.84804100
23FES1.77204682
24TAOK31.76944861
25TAOK11.68860510
26IKBKB1.68290167
27GRK61.61135055
28JAK21.59195419
29IRAK21.56417662
30HCK1.54627815
31JAK11.52328287
32TNK21.47197122
33MAP3K111.46598020
34LYN1.41637221
35MAP3K131.39170487
36BTK1.36086405
37GRK71.34184397
38SYK1.32071266
39MAP3K11.31450564
40TAOK21.27414004
41PRPF4B1.23350123
42LCK1.07588261
43TGFBR21.05850907
44STK101.04365828
45YES11.01808202
46KSR21.01502902
47STK241.01314867
48MARK30.90734140
49MAP3K50.85133755
50CSF1R0.85115570
51ITK0.84923678
52KIT0.83003267
53ACVR1B0.82762138
54TEC0.81360400
55EPHA30.77378156
56CHUK0.76019808
57MAP3K120.73898610
58MOS0.73481016
59MAP3K20.71514232
60DYRK30.68760739
61KSR10.62800193
62MAP2K60.60818925
63MST40.57958392
64TESK20.53551143
65PDK10.53018169
66PTK60.47897253
67PIM10.47653379
68FYN0.47154856
69FGFR30.46179640
70PIK3CG0.45944630
71ALK0.45716742
72DAPK20.43703360
73HIPK20.42158893
74RAF10.41330316
75PRKCQ0.40928041
76CDC42BPA0.39397682
77NLK0.36695318
78MAP3K60.36161133
79CDK190.34812304
80MAP2K40.34763826
81PTK2B0.33987126
82ADRBK20.33975346
83PDPK10.33887377
84WNK10.32070324
85MAPK70.31896178
86PRKG20.31629329
87PRKCD0.29932271
88MAPKAPK20.29389680
89ABL10.27703458
90PAK40.25625809
91EGFR0.24934131
92LRRK20.23293648
93CLK10.22878595
94INSR0.20286834
95PRKD20.19257294
96MARK20.19022516
97STK110.18616548
98SIK20.18327342
99FGFR40.16947656
100MAP3K80.16222927

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.21673262
2Osteoclast differentiation_Homo sapiens_hsa043803.01021318
3Staphylococcus aureus infection_Homo sapiens_hsa051502.84852617
4NOD-like receptor signaling pathway_Homo sapiens_hsa046212.81768854
5Allograft rejection_Homo sapiens_hsa053302.78203962
6Graft-versus-host disease_Homo sapiens_hsa053322.76379786
7Legionellosis_Homo sapiens_hsa051342.65767438
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.62432435
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.52806342
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.46736290
11Autoimmune thyroid disease_Homo sapiens_hsa053202.42289009
12Malaria_Homo sapiens_hsa051442.32388985
13Tuberculosis_Homo sapiens_hsa051522.26889558
14Type I diabetes mellitus_Homo sapiens_hsa049402.20021099
15Measles_Homo sapiens_hsa051622.02612095
16TNF signaling pathway_Homo sapiens_hsa046682.01916499
17Rheumatoid arthritis_Homo sapiens_hsa053232.00330481
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.96881289
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.88985196
20Influenza A_Homo sapiens_hsa051641.82849285
21Hematopoietic cell lineage_Homo sapiens_hsa046401.80247773
22Asthma_Homo sapiens_hsa053101.77012752
23Antigen processing and presentation_Homo sapiens_hsa046121.70601706
24Chemokine signaling pathway_Homo sapiens_hsa040621.69228928
25B cell receptor signaling pathway_Homo sapiens_hsa046621.68368199
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.66870814
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.65192022
28Toxoplasmosis_Homo sapiens_hsa051451.62495985
29Pertussis_Homo sapiens_hsa051331.61510004
30Primary immunodeficiency_Homo sapiens_hsa053401.61258132
31African trypanosomiasis_Homo sapiens_hsa051431.58774227
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.58709393
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.58270475
34Herpes simplex infection_Homo sapiens_hsa051681.54344851
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.54091366
36Salmonella infection_Homo sapiens_hsa051321.52801949
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.49314334
38Viral myocarditis_Homo sapiens_hsa054161.46080359
39T cell receptor signaling pathway_Homo sapiens_hsa046601.40897517
40Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.38031182
41Phagosome_Homo sapiens_hsa041451.36901383
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.31846486
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.25073899
44Shigellosis_Homo sapiens_hsa051311.24571659
45Hepatitis B_Homo sapiens_hsa051611.19487303
46Hepatitis C_Homo sapiens_hsa051601.17289344
47Acute myeloid leukemia_Homo sapiens_hsa052211.05693118
48Apoptosis_Homo sapiens_hsa042100.92513335
49Epstein-Barr virus infection_Homo sapiens_hsa051690.80835653
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79516687
51Leukocyte transendothelial migration_Homo sapiens_hsa046700.78479549
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77152251
53Lysosome_Homo sapiens_hsa041420.74193332
54SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73703094
55Amoebiasis_Homo sapiens_hsa051460.73049478
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69134500
57Prolactin signaling pathway_Homo sapiens_hsa049170.68670217
58Dorso-ventral axis formation_Homo sapiens_hsa043200.68608851
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.64230953
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61721120
61Other glycan degradation_Homo sapiens_hsa005110.61121828
62Pancreatic cancer_Homo sapiens_hsa052120.60720524
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59829210
64Platelet activation_Homo sapiens_hsa046110.59718334
65HIF-1 signaling pathway_Homo sapiens_hsa040660.58146770
66VEGF signaling pathway_Homo sapiens_hsa043700.56985896
67Renal cell carcinoma_Homo sapiens_hsa052110.54322756
68Bladder cancer_Homo sapiens_hsa052190.53763691
69Viral carcinogenesis_Homo sapiens_hsa052030.52840673
70Non-small cell lung cancer_Homo sapiens_hsa052230.52774721
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49673581
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47505012
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47208891
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.44857988
75Collecting duct acid secretion_Homo sapiens_hsa049660.44608717
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.44243755
77HTLV-I infection_Homo sapiens_hsa051660.43080283
78Endocytosis_Homo sapiens_hsa041440.43047969
79FoxO signaling pathway_Homo sapiens_hsa040680.42023881
80Regulation of autophagy_Homo sapiens_hsa041400.41033752
81Chronic myeloid leukemia_Homo sapiens_hsa052200.40501600
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37899140
83Complement and coagulation cascades_Homo sapiens_hsa046100.37378010
84Type II diabetes mellitus_Homo sapiens_hsa049300.33015988
85MAPK signaling pathway_Homo sapiens_hsa040100.30691518
86Notch signaling pathway_Homo sapiens_hsa043300.29521503
87Prion diseases_Homo sapiens_hsa050200.24793994
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.24586416
89Insulin resistance_Homo sapiens_hsa049310.24109844
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.22722640
91Mineral absorption_Homo sapiens_hsa049780.19578173
92GnRH signaling pathway_Homo sapiens_hsa049120.18850160
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.18090930
94Rap1 signaling pathway_Homo sapiens_hsa040150.14792026
95Systemic lupus erythematosus_Homo sapiens_hsa053220.14572283
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.13829685
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.11014620
98Fatty acid biosynthesis_Homo sapiens_hsa000610.10216282
99Arachidonic acid metabolism_Homo sapiens_hsa005900.09935034
100mTOR signaling pathway_Homo sapiens_hsa041500.08535771

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