NAGS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The N-acetylglutamate synthase gene encodes a mitochondrial enzyme that catalyzes the formation of N-acetylglutamate (NAG) from glutamate and acetyl coenzyme-A. NAG is a cofactor of carbamyl phosphate synthetase I (CPSI), the first enzyme of the urea cycle in mammals. This gene may regulate ureagenesis by altering NAG availability and, thereby, CPSI activity. Deficiencies in N-acetylglutamate synthase have been associated with hyperammonemia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)8.12428797
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.53050739
3L-phenylalanine catabolic process (GO:0006559)7.53050739
4L-phenylalanine metabolic process (GO:0006558)7.22784711
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.22784711
6exogenous drug catabolic process (GO:0042738)6.90474217
7aromatic amino acid family catabolic process (GO:0009074)6.78728877
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.49966952
9omega-hydroxylase P450 pathway (GO:0097267)6.41127944
10tryptophan catabolic process (GO:0006569)6.15305709
11indole-containing compound catabolic process (GO:0042436)6.15305709
12indolalkylamine catabolic process (GO:0046218)6.15305709
13drug metabolic process (GO:0017144)6.01960774
14kynurenine metabolic process (GO:0070189)6.00123105
15bile acid biosynthetic process (GO:0006699)5.90388536
16tryptophan metabolic process (GO:0006568)5.78716694
17glyoxylate metabolic process (GO:0046487)5.74660784
18high-density lipoprotein particle remodeling (GO:0034375)5.67321327
19negative regulation of fibrinolysis (GO:0051918)5.61410955
20alpha-linolenic acid metabolic process (GO:0036109)5.47154340
21* urea metabolic process (GO:0019627)5.41090177
22* urea cycle (GO:0000050)5.41090177
23regulation of fibrinolysis (GO:0051917)5.41018474
24cysteine metabolic process (GO:0006534)5.38499726
25sulfur amino acid catabolic process (GO:0000098)5.36785613
26peptidyl-glutamic acid carboxylation (GO:0017187)5.34486752
27protein carboxylation (GO:0018214)5.34486752
28regulation of protein activation cascade (GO:2000257)5.34030103
29complement activation, alternative pathway (GO:0006957)5.32752417
30serine family amino acid catabolic process (GO:0009071)5.12899529
31bile acid metabolic process (GO:0008206)5.06153279
32regulation of cholesterol esterification (GO:0010872)5.03025497
33regulation of triglyceride catabolic process (GO:0010896)5.00861316
34reverse cholesterol transport (GO:0043691)4.99583228
35regulation of complement activation (GO:0030449)4.98143785
36aromatic amino acid family metabolic process (GO:0009072)4.94386975
37* nitrogen cycle metabolic process (GO:0071941)4.93178641
38protein-lipid complex remodeling (GO:0034368)4.87002870
39macromolecular complex remodeling (GO:0034367)4.87002870
40plasma lipoprotein particle remodeling (GO:0034369)4.87002870
41hormone catabolic process (GO:0042447)4.84985254
42fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.84200709
43homocysteine metabolic process (GO:0050667)4.81918610
44tyrosine metabolic process (GO:0006570)4.76922739
45phospholipid efflux (GO:0033700)4.76465030
46acylglycerol homeostasis (GO:0055090)4.69739391
47triglyceride homeostasis (GO:0070328)4.69739391
48fat-soluble vitamin biosynthetic process (GO:0042362)4.64164720
49negative regulation of sterol transport (GO:0032372)4.63243230
50negative regulation of cholesterol transport (GO:0032375)4.63243230
51regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.62974243
52alpha-amino acid catabolic process (GO:1901606)4.62350880
53lysine metabolic process (GO:0006553)4.57103688
54lysine catabolic process (GO:0006554)4.57103688
55amino-acid betaine metabolic process (GO:0006577)4.56682643
56angiotensin maturation (GO:0002003)4.56637388
57plasma lipoprotein particle clearance (GO:0034381)4.43919431
58glycine metabolic process (GO:0006544)4.43591082
59bile acid and bile salt transport (GO:0015721)4.42647395
60cellular ketone body metabolic process (GO:0046950)4.37913503
61coenzyme catabolic process (GO:0009109)4.37764180
62cholesterol efflux (GO:0033344)4.35423502
63indolalkylamine metabolic process (GO:0006586)4.35310171
64imidazole-containing compound metabolic process (GO:0052803)4.32604464
65NADH metabolic process (GO:0006734)4.28643030
66amine catabolic process (GO:0009310)4.26217362
67cellular biogenic amine catabolic process (GO:0042402)4.26217362
68cellular amino acid catabolic process (GO:0009063)4.25627008
69cellular glucuronidation (GO:0052695)4.24885150
70regulation of plasminogen activation (GO:0010755)4.23351522
71phenylpropanoid metabolic process (GO:0009698)4.22357597
72serine family amino acid metabolic process (GO:0009069)4.19767101
73plasma lipoprotein particle assembly (GO:0034377)4.18916166
74proline metabolic process (GO:0006560)4.18204553
75alkaloid metabolic process (GO:0009820)4.14504669
76benzene-containing compound metabolic process (GO:0042537)4.09208457
77cellular modified amino acid catabolic process (GO:0042219)4.09134657
78fructose metabolic process (GO:0006000)4.08247928
79oxidative demethylation (GO:0070989)4.04100856
80ethanol oxidation (GO:0006069)4.03982685
81serine family amino acid biosynthetic process (GO:0009070)4.03216047
82negative regulation of hemostasis (GO:1900047)4.02493346
83negative regulation of blood coagulation (GO:0030195)4.02493346
84acute-phase response (GO:0006953)4.01394104
85fibrinolysis (GO:0042730)4.00184154
86drug catabolic process (GO:0042737)4.00000994
87dicarboxylic acid biosynthetic process (GO:0043650)3.99728569
88* glutamate metabolic process (GO:0006536)3.98733202
89low-density lipoprotein particle remodeling (GO:0034374)3.98574533
90positive regulation of lipoprotein lipase activity (GO:0051006)3.98057342
91positive regulation of triglyceride lipase activity (GO:0061365)3.98057342
92aldehyde catabolic process (GO:0046185)3.96975247
93ethanol metabolic process (GO:0006067)3.92003902
94blood coagulation, intrinsic pathway (GO:0007597)3.87472865
95very-low-density lipoprotein particle assembly (GO:0034379)3.86458748
96regulation of bile acid biosynthetic process (GO:0070857)3.85330965
97cholesterol homeostasis (GO:0042632)3.83267309
98positive regulation of fatty acid biosynthetic process (GO:0045723)3.82942819
99cofactor catabolic process (GO:0051187)3.81499995
100positive regulation of lipid catabolic process (GO:0050996)3.79279483
101complement activation, classical pathway (GO:0006958)3.78806031
102ketone body metabolic process (GO:1902224)3.78720131
103sterol homeostasis (GO:0055092)3.77175724
104uronic acid metabolic process (GO:0006063)3.76886444
105glucuronate metabolic process (GO:0019585)3.76886444
106protein-lipid complex assembly (GO:0065005)3.75576554
107negative regulation of lipase activity (GO:0060192)3.75288273
108phospholipid homeostasis (GO:0055091)3.74694870
109negative regulation of coagulation (GO:0050819)3.74255497
110plasma lipoprotein particle organization (GO:0071827)3.73811078
111intestinal absorption (GO:0050892)3.73266623
112protein activation cascade (GO:0072376)3.72708672
113complement activation (GO:0006956)3.72602866
114carboxylic acid catabolic process (GO:0046395)3.71175676
115organic acid catabolic process (GO:0016054)3.71175676
116regulation of cholesterol homeostasis (GO:2000188)3.70347613
117cytolysis (GO:0019835)3.67001613
118negative regulation of wound healing (GO:0061045)3.65885201
119* arginine metabolic process (GO:0006525)3.64811072
120acetyl-CoA metabolic process (GO:0006084)3.61533685
121intestinal cholesterol absorption (GO:0030299)3.60176221
122flavonoid metabolic process (GO:0009812)3.59658789
123NAD biosynthetic process (GO:0009435)3.58026677
124opsonization (GO:0008228)3.50336474
125positive regulation of triglyceride metabolic process (GO:0090208)3.46906047
126diacylglycerol metabolic process (GO:0046339)3.37840723
127arginine catabolic process (GO:0006527)3.35576476
128regulation of humoral immune response (GO:0002920)3.31182709
129phosphate ion transmembrane transport (GO:0035435)3.30940342
130negative regulation of protein activation cascade (GO:2000258)3.30334653
131lipoprotein metabolic process (GO:0042157)3.27589424
132* glutamine family amino acid biosynthetic process (GO:0009084)3.24005936
133regulation of cholesterol metabolic process (GO:0090181)3.23744095
134heme transport (GO:0015886)3.21839210
135proline biosynthetic process (GO:0006561)3.18104620
136renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.14458553
137protein-lipid complex subunit organization (GO:0071825)3.09255947
138regulation of cholesterol biosynthetic process (GO:0045540)3.08872114
139renal system process involved in regulation of blood volume (GO:0001977)3.07293105

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.38483138
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.23269316
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.03305635
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.47575570
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.31207558
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.19279803
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.89234754
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.05380711
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.03978993
10TP63_17297297_ChIP-ChIP_HaCaT_Human3.32117194
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.10951447
12TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.06801111
13* ELK3_25401928_ChIP-Seq_HUVEC_Human2.06374610
14* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9583210
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98694036
16RACK7_27058665_Chip-Seq_MCF-7_Human1.89878932
17TET1_21451524_ChIP-Seq_MESCs_Mouse1.71077207
18SRY_22984422_ChIP-ChIP_TESTIS_Rat1.67386504
19STAT6_21828071_ChIP-Seq_BEAS2B_Human1.61379359
20TRIM28_21343339_ChIP-Seq_HEK293_Human1.59393252
21FOXA2_19822575_ChIP-Seq_HepG2_Human1.58638788
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.53456967
23CLOCK_20551151_ChIP-Seq_293T_Human1.52227161
24HTT_18923047_ChIP-ChIP_STHdh_Human1.51200487
25BCL6_27268052_Chip-Seq_Bcells_Human1.50777355
26* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.50576566
27TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49646991
28GATA1_22025678_ChIP-Seq_K562_Human1.46564135
29VDR_21846776_ChIP-Seq_THP-1_Human1.46128143
30HNF4A_19822575_ChIP-Seq_HepG2_Human1.43947797
31P68_20966046_ChIP-Seq_HELA_Human1.41982337
32TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41030805
33* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38448217
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34434478
35KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.34235212
36KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.30076819
37* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29733201
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.28244160
39SA1_27219007_Chip-Seq_ERYTHROID_Human1.28057543
40SMC4_20622854_ChIP-Seq_HELA_Human1.27614937
41KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26621231
42HIF1A_21447827_ChIP-Seq_MCF-7_Human1.22832453
43RXRA_24833708_ChIP-Seq_LIVER_Mouse1.22797661
44STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.22447800
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22376929
46P63_26484246_Chip-Seq_KERATINOCYTES_Human1.17460117
47CTCF_27219007_Chip-Seq_Bcells_Human1.15683367
48SA1_27219007_Chip-Seq_Bcells_Human1.14984654
49CTCF_20526341_ChIP-Seq_ESCs_Human1.14386896
50JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.12446682
51E2F1_20622854_ChIP-Seq_HELA_Human1.11897956
52BP1_19119308_ChIP-ChIP_Hs578T_Human1.10164897
53RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09999439
54ATF3_27146783_Chip-Seq_COLON_Human1.09890419
55ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09742527
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08715711
57ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08575016
58CTCF_27219007_Chip-Seq_ERYTHROID_Human1.07885228
59PHF8_20622854_ChIP-Seq_HELA_Human1.07327861
60ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04446250
61TP53_22127205_ChIP-Seq_IMR90_Human1.02823119
62KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02702589
63SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02228404
64TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02196698
65SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.01737627
66IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00956841
67* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98660791
68ELF1_20517297_ChIP-Seq_JURKAT_Human0.97936937
69DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95825975
70UBF1/2_26484160_Chip-Seq_HMECs_Human0.95655330
71TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.95637896
72ETS1_21867929_ChIP-Seq_TH2_Mouse0.95594163
73* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95351596
74CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.94197819
75CREB1_26743006_Chip-Seq_LNCaP_Human0.93574286
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93143614
77OCT4_18692474_ChIP-Seq_MEFs_Mouse0.92597988
78* CTCF_21964334_Chip-Seq_Bcells_Human0.92551975
79NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.92085220
80P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91416345
81SOX2_21211035_ChIP-Seq_LN229_Human0.90024086
82* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.89481080
83GATA4_25053715_ChIP-Seq_YYC3_Human0.89333944
84TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88706208
85PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87461205
86IRF8_22096565_ChIP-ChIP_GC-B_Human0.86042103
87ZNF263_19887448_ChIP-Seq_K562_Human0.84299873
88SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.81110706
89AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80527136
90ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.80298598
91KAP1_22055183_ChIP-Seq_ESCs_Mouse0.79964229
92RARG_19884340_ChIP-ChIP_MEFs_Mouse0.79937106
93SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79295008
94RARA_24833708_ChIP-Seq_LIVER_Mouse0.79004682
95PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.78854095
96* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.77563860
97Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.72020571
98BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.71786668
99RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.70241716
100CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.69922649
101NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.69047048
102SALL4_18804426_ChIP-ChIP_XEN_Mouse0.67256749
103RARB_24833708_ChIP-Seq_LIVER_Mouse0.67168583
104AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.66545127
105ESR2_21235772_ChIP-Seq_MCF-7_Human0.65806599
106NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.64658475
107RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63461144
108BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61635252
109STAT3_1855785_ChIP-Seq_MESCs_Mouse0.61458266
110CEBPB_22108803_ChIP-Seq_LS180_Human0.59346054
111CDX2_20551321_ChIP-Seq_CACO-2_Human0.59308609
112NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.57694971
113NRF2_20460467_ChIP-Seq_MEFs_Mouse0.57694971
114* LXR_22292898_ChIP-Seq_THP-1_Human0.54471323
115AR_20517297_ChIP-Seq_VCAP_Human0.53515511
116FOXA1_25552417_ChIP-Seq_VCAP_Human0.52507521
117EGR1_19032775_ChIP-ChIP_M12_Human0.52201444
118PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.51944183
119MYC_19915707_ChIP-ChIP_AK7_Human0.51700464
120FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.51491163
121FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.50790916
122GATA6_25053715_ChIP-Seq_YYC3_Human0.49637121
123NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.48807264
124ESET_19884257_ChIP-Seq_ESCs_Mouse0.48527980
125P53_21459846_ChIP-Seq_SAOS-2_Human0.47365827
126PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.47184776
127STAT1_17558387_ChIP-Seq_HELA_Human0.47054353
128E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.47013724
129GATA1_19941827_ChIP-Seq_MEL_Mouse0.46214611
130ESR1_21235772_ChIP-Seq_MCF-7_Human0.45559478
131CBP_21632823_ChIP-Seq_H3396_Human0.45376883
132FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.44910163
133PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.44891977
134TAF2_19829295_ChIP-Seq_ESCs_Human0.44725066
135GATA1_19941826_ChIP-Seq_K562_Human0.44496661
136PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.44150572
137GATA2_19941826_ChIP-Seq_K562_Human0.42933691
138FOXO3_23340844_ChIP-Seq_DLD1_Human0.42543018
139PPAR_26484153_Chip-Seq_NCI-H1993_Human0.41588378
140* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.41444128
141SPI1_26923725_Chip-Seq_HPCs_Mouse0.38917745
142CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.38113772
143STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.37524271
144ERG_21242973_ChIP-ChIP_JURKAT_Human0.36977243
145BCOR_27268052_Chip-Seq_Bcells_Human0.36802298
146CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.36394403
147LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.35939522
148ERG_20517297_ChIP-Seq_VCAP_Human0.35670776
149* MYC_27129775_Chip-Seq_CORNEA_Mouse0.35088967
150SOX2_20726797_ChIP-Seq_SW620_Human0.34868024
151SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.34668154
152NCOR_22424771_ChIP-Seq_293T_Human0.33775086
153OCT4_20526341_ChIP-Seq_ESCs_Human0.33259606
154FOXH1_21741376_ChIP-Seq_EPCs_Human0.33223145
155GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.33083407
156GATA3_24758297_ChIP-Seq_MCF-7_Human0.32869423

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.22304633
2MP0005360_urolithiasis7.73081600
3MP0005085_abnormal_gallbladder_physiolo6.42818340
4MP0005365_abnormal_bile_salt6.11807026
5MP0008875_abnormal_xenobiotic_pharmacok5.09548594
6MP0003806_abnormal_nucleotide_metabolis4.26320846
7MP0003252_abnormal_bile_duct3.91389802
8MP0010329_abnormal_lipoprotein_level3.62924904
9MP0009840_abnormal_foam_cell3.42305845
10MP0005083_abnormal_biliary_tract2.99553583
11MP0001666_abnormal_nutrient_absorption2.77865772
12MP0005332_abnormal_amino_acid2.75172000
13MP0003195_calcinosis2.73949072
14MP0003191_abnormal_cellular_cholesterol2.39952640
15MP0005409_darkened_coat_color2.22212227
16MP0000609_abnormal_liver_physiology2.17089509
17MP0004019_abnormal_vitamin_homeostasis2.17020189
18MP0002118_abnormal_lipid_homeostasis2.08654963
19MP0002138_abnormal_hepatobiliary_system1.93195408
20MP0003868_abnormal_feces_composition1.89824037
21MP0005319_abnormal_enzyme/_coenzyme1.82960341
22MP0000566_synostosis1.81386935
23MP0001764_abnormal_homeostasis1.69851400
24MP0009697_abnormal_copulation1.61201914
25MP0010234_abnormal_vibrissa_follicle1.61183797
26MP0005584_abnormal_enzyme/coenzyme_acti1.55124379
27MP0005451_abnormal_body_composition1.45642480
28MP0004858_abnormal_nervous_system1.39402616
29MP0003011_delayed_dark_adaptation1.39199380
30MP0003656_abnormal_erythrocyte_physiolo1.35880600
31MP0005058_abnormal_lysosome_morphology1.35433053
32MP0003183_abnormal_peptide_metabolism1.32865809
33MP0000678_abnormal_parathyroid_gland1.27436268
34MP0003186_abnormal_redox_activity1.25150225
35MP0009643_abnormal_urine_homeostasis1.23203370
36MP0003705_abnormal_hypodermis_morpholog1.17891957
37MP0000598_abnormal_liver_morphology1.17880808
38MP0005647_abnormal_sex_gland1.10843457
39MP0009379_abnormal_foot_pigmentation1.07958578
40MP0000604_amyloidosis1.06248418
41MP0002254_reproductive_system_inflammat1.06239940
42MP0009764_decreased_sensitivity_to1.05459532
43MP0005257_abnormal_intraocular_pressure1.03528534
44MP0000467_abnormal_esophagus_morphology1.01618244
45MP0009763_increased_sensitivity_to1.00784355
46MP0005023_abnormal_wound_healing0.99244363
47MP0010155_abnormal_intestine_physiology0.97249982
48MP0005636_abnormal_mineral_homeostasis0.94516737
49MP0004233_abnormal_muscle_weight0.93726245
50MP0001849_ear_inflammation0.93147304
51MP0003879_abnormal_hair_cell0.93052226
52MP0000858_altered_metastatic_potential0.92714814
53MP0008469_abnormal_protein_level0.90183362
54MP0010368_abnormal_lymphatic_system0.88284212
55MP0009642_abnormal_blood_homeostasis0.87597793
56MP0003453_abnormal_keratinocyte_physiol0.84809446
57MP0003566_abnormal_cell_adhesion0.84494464
58MP0008260_abnormal_autophagy0.83813495
59MP0006036_abnormal_mitochondrial_physio0.82729598
60MP0005408_hypopigmentation0.82639375
61MP0005376_homeostasis/metabolism_phenot0.81252052
62MP0005084_abnormal_gallbladder_morpholo0.79907947
63MP0009765_abnormal_xenobiotic_induced0.78703350
64MP0002876_abnormal_thyroid_physiology0.76693363
65MP0002078_abnormal_glucose_homeostasis0.76428746
66MP0000537_abnormal_urethra_morphology0.73971212
67MP0004272_abnormal_basement_membrane0.73227176
68MP0005670_abnormal_white_adipose0.72444626
69MP0002971_abnormal_brown_adipose0.71000817
70MP0005220_abnormal_exocrine_pancreas0.70171139
71MP0000538_abnormal_urinary_bladder0.69297992
72MP0000490_abnormal_crypts_of0.68719663
73MP0005334_abnormal_fat_pad0.68307374
74MP0005266_abnormal_metabolism0.67722346
75MP0009053_abnormal_anal_canal0.66552023
76MP0002089_abnormal_postnatal_growth/wei0.66175908
77MP0005501_abnormal_skin_physiology0.64112896
78MP0005535_abnormal_body_temperature0.64001389
79MP0004130_abnormal_muscle_cell0.62522636
80MP0001661_extended_life_span0.62394265
81MP0000477_abnormal_intestine_morphology0.61415059
82MP0003690_abnormal_glial_cell0.61262719
83MP0005448_abnormal_energy_balance0.58144512
84MP0006035_abnormal_mitochondrial_morpho0.58067104
85MP0000639_abnormal_adrenal_gland0.57852941
86MP0001216_abnormal_epidermal_layer0.57733567
87MP0003329_amyloid_beta_deposits0.57547432
88MP0009785_altered_susceptibility_to0.57265600
89MP0002234_abnormal_pharynx_morphology0.57031473
90MP0001756_abnormal_urination0.55860589
91MP0005464_abnormal_platelet_physiology0.55490382
92MP0001663_abnormal_digestive_system0.55230521
93MP0001664_abnormal_digestion0.54957577
94MP0003718_maternal_effect0.53749670
95MP0002822_catalepsy0.53626430
96MP0002896_abnormal_bone_mineralization0.51750841
97MP0001915_intracranial_hemorrhage0.50040317
98MP0001765_abnormal_ion_homeostasis0.49574044
99MP0004043_abnormal_pH_regulation0.49240449
100MP0002098_abnormal_vibrissa_morphology0.49077290
101MP0002249_abnormal_larynx_morphology0.48578750
102MP0005395_other_phenotype0.48576935
103MP0005197_abnormal_uvea_morphology0.47680401
104MP0001873_stomach_inflammation0.47579162
105MP0008873_increased_physiological_sensi0.46446233
106MP0003638_abnormal_response/metabolism_0.45988901
107MP0004147_increased_porphyrin_level0.45699908
108MP0003315_abnormal_perineum_morphology0.45076121
109MP0002136_abnormal_kidney_physiology0.44896438
110MP0003436_decreased_susceptibility_to0.44526223
111MP0004782_abnormal_surfactant_physiolog0.42853839
112MP0008874_decreased_physiological_sensi0.42840446
113MP0003724_increased_susceptibility_to0.41240182
114MP0002928_abnormal_bile_duct0.40949042
115MP0005166_decreased_susceptibility_to0.40854858
116MP0008872_abnormal_physiological_respon0.40771317
117MP0003953_abnormal_hormone_level0.39832674
118MP0003075_altered_response_to0.39362915
119MP0002796_impaired_skin_barrier0.38325486
120MP0004381_abnormal_hair_follicle0.38060651
121MP0005248_abnormal_Harderian_gland0.37483517
122MP0005666_abnormal_adipose_tissue0.35700875
123MP0000579_abnormal_nail_morphology0.34840319
124MP0009115_abnormal_fat_cell0.33835265
125MP0004264_abnormal_extraembryonic_tissu0.33727854
126MP0009672_abnormal_birth_weight0.33717162
127MP0006082_CNS_inflammation0.32827380
128MP0009384_cardiac_valve_regurgitation0.32525694
129MP0001243_abnormal_dermal_layer0.32433057
130MP0000249_abnormal_blood_vessel0.31771789
131MP0001845_abnormal_inflammatory_respons0.30222651
132MP0002837_dystrophic_cardiac_calcinosis0.30152253
133MP0002970_abnormal_white_adipose0.30150383
134MP0001881_abnormal_mammary_gland0.29898937
135MP0002132_abnormal_respiratory_system0.29213179
136MP0004883_abnormal_blood_vessel0.29160212
137MP0001853_heart_inflammation0.29070683
138MP0000230_abnormal_systemic_arterial0.29068647
139MP0002168_other_aberrant_phenotype0.25097798
140MP0002060_abnormal_skin_morphology0.24002287
141MP0005164_abnormal_response_to0.23597484

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.37283739
2Deep venous thrombosis (HP:0002625)7.32090649
3Intrahepatic cholestasis (HP:0001406)7.25863419
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.76446165
5Hypobetalipoproteinemia (HP:0003563)6.70633362
6Prolonged partial thromboplastin time (HP:0003645)6.55364636
7Xanthomatosis (HP:0000991)6.27779973
8Hyperlipoproteinemia (HP:0010980)5.53631816
9Complement deficiency (HP:0004431)5.37371808
10Hypolipoproteinemia (HP:0010981)4.94682983
11Joint hemorrhage (HP:0005261)4.76481970
12Epidermoid cyst (HP:0200040)4.49398930
13Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.49356635
14Abnormality of the common coagulation pathway (HP:0010990)4.46629110
15* Hyperammonemia (HP:0001987)4.40090701
16Hyperglycinemia (HP:0002154)4.37347199
17Abnormality of glutamine family amino acid metabolism (HP:0010902)4.33085874
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.30432008
19Abnormality of methionine metabolism (HP:0010901)4.27743851
20Hypoalphalipoproteinemia (HP:0003233)4.21102367
21Fat malabsorption (HP:0002630)4.18680596
22Ketosis (HP:0001946)4.18486107
23Abnormality of aspartate family amino acid metabolism (HP:0010899)4.17048751
24Hyperglycinuria (HP:0003108)3.96481904
25Abnormality of complement system (HP:0005339)3.93042509
26Abnormality of pyrimidine metabolism (HP:0004353)3.92157317
27Abnormality of glycine metabolism (HP:0010895)3.91828818
28Abnormality of serine family amino acid metabolism (HP:0010894)3.91828818
29Hypoglycemic coma (HP:0001325)3.79684998
30Abnormality of the intrinsic pathway (HP:0010989)3.78875734
31Conjugated hyperbilirubinemia (HP:0002908)3.73883084
32Hypercholesterolemia (HP:0003124)3.64431809
33Hyperbilirubinemia (HP:0002904)3.36799934
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.36567163
35Abnormality of fatty-acid metabolism (HP:0004359)3.30507534
36Spontaneous abortion (HP:0005268)3.10782799
37Steatorrhea (HP:0002570)3.10523594
38Abnormality of nucleobase metabolism (HP:0010932)3.09087000
39Abnormality of serum amino acid levels (HP:0003112)3.05420251
40Delayed CNS myelination (HP:0002188)3.00877340
41Hypochromic microcytic anemia (HP:0004840)3.00520395
42Hepatocellular carcinoma (HP:0001402)2.96112648
43Ketoacidosis (HP:0001993)2.94822374
44Myocardial infarction (HP:0001658)2.94056184
45Acanthocytosis (HP:0001927)2.89248958
46Metabolic acidosis (HP:0001942)2.79749217
47Skin nodule (HP:0200036)2.76457001
48Systemic lupus erythematosus (HP:0002725)2.74941318
49Abnormality of purine metabolism (HP:0004352)2.67551842
50Popliteal pterygium (HP:0009756)2.62908603
51Widely patent fontanelles and sutures (HP:0004492)2.59766977
52Vascular calcification (HP:0004934)2.56540818
53Dicarboxylic aciduria (HP:0003215)2.55533465
54Abnormality of dicarboxylic acid metabolism (HP:0010995)2.55533465
55* Lethargy (HP:0001254)2.49684410
56Abnormal gallbladder morphology (HP:0012437)2.48123595
57Glomerulonephritis (HP:0000099)2.46490858
58Spastic diplegia (HP:0001264)2.44239447
59Cholelithiasis (HP:0001081)2.43287600
60Malnutrition (HP:0004395)2.42453883
61Abnormal gallbladder physiology (HP:0012438)2.42050849
62Cholecystitis (HP:0001082)2.42050849
63Hypoglycemic seizures (HP:0002173)2.41397130
64Cerebral edema (HP:0002181)2.41320439
65Gout (HP:0001997)2.38905728
66Recurrent gram-negative bacterial infections (HP:0005420)2.38183106
67Purpura (HP:0000979)2.35123105
68Irritability (HP:0000737)2.35020499
69Amyloidosis (HP:0011034)2.34795622
70Thin bony cortex (HP:0002753)2.34427495
71Mitral stenosis (HP:0001718)2.33057748
72Elevated alkaline phosphatase (HP:0003155)2.32428713
73Neonatal onset (HP:0003623)2.32386568
74Abnormality of alkaline phosphatase activity (HP:0004379)2.29084941
75Cardiovascular calcification (HP:0011915)2.26692236
76Gingival bleeding (HP:0000225)2.25535235
77Hypophosphatemia (HP:0002148)2.23273843
78Esophageal varix (HP:0002040)2.22705743
79Poikilocytosis (HP:0004447)2.22014936
80Reduced antithrombin III activity (HP:0001976)2.20310530
81Abnormality of the Achilles tendon (HP:0005109)2.20213906
82Late onset (HP:0003584)2.14955161
83Pancreatitis (HP:0001733)2.14781022
84Brushfield spots (HP:0001088)2.14254867
85Menorrhagia (HP:0000132)2.13540438
86Sensorimotor neuropathy (HP:0007141)2.12474946
87Thrombophlebitis (HP:0004418)2.10186522
88Vertebral compression fractures (HP:0002953)2.09633307
89Focal segmental glomerulosclerosis (HP:0000097)2.09592148
90Ileus (HP:0002595)2.08121420
91Wide cranial sutures (HP:0010537)2.05754641
92Glycosuria (HP:0003076)2.05345945
93Abnormality of urine glucose concentration (HP:0011016)2.05345945
94Enlarged kidneys (HP:0000105)2.05032168
95Nephrolithiasis (HP:0000787)2.03713989
96Abnormality of the gallbladder (HP:0005264)2.01770702
97Opisthotonus (HP:0002179)2.01508605
98Entropion (HP:0000621)1.99655550
99Hemorrhage of the eye (HP:0011885)1.99278711
100* Vomiting (HP:0002013)1.98700247
101Hyperinsulinemic hypoglycemia (HP:0000825)1.97914512
102Hydroxyprolinuria (HP:0003080)1.97591147
103Abnormality of proline metabolism (HP:0010907)1.97591147
104Generalized aminoaciduria (HP:0002909)1.97357055
105Abnormality of iron homeostasis (HP:0011031)1.96678911
106Pterygium (HP:0001059)1.95885388
107Abnormal urine phosphate concentration (HP:0012599)1.95867568
108Abnormality of transition element cation homeostasis (HP:0011030)1.95348089
109Poikiloderma (HP:0001029)1.95109763
110Hyperphosphaturia (HP:0003109)1.92830763
111Rickets (HP:0002748)1.92652379
112Glomerulosclerosis (HP:0000096)1.92165749
113Abnormal cartilage morphology (HP:0002763)1.90090227
114Abdominal distention (HP:0003270)1.87004221
115Facial shape deformation (HP:0011334)1.84907704
116Potter facies (HP:0002009)1.84907704
117Elevated hepatic transaminases (HP:0002910)1.81923355
118Hypophosphatemic rickets (HP:0004912)1.81332830
119Abnormal enzyme/coenzyme activity (HP:0012379)1.80437728
120Alkalosis (HP:0001948)1.80218368
121Ulnar bowing (HP:0003031)1.79168043
122Renal cortical cysts (HP:0000803)1.78692713
123Delayed epiphyseal ossification (HP:0002663)1.78676964
124Urinary glycosaminoglycan excretion (HP:0003541)1.78659765
125Mucopolysacchariduria (HP:0008155)1.78659765
126Reticulocytosis (HP:0001923)1.78351111
127Abnormality of vitamin metabolism (HP:0100508)1.76359572
128Status epilepticus (HP:0002133)1.76175508
129Bone pain (HP:0002653)1.75681905
130Nephritis (HP:0000123)1.75379375
131Increased serum ferritin (HP:0003281)1.74130859
132Osteomalacia (HP:0002749)1.74043296
133Proximal tubulopathy (HP:0000114)1.72194234
134Abnormality of carpal bone ossification (HP:0006257)1.71411722
135Abnormal tarsal ossification (HP:0008369)1.70409762
136Lower limb hyperreflexia (HP:0002395)1.69098019

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.11857380
2ERN14.65250553
3FGFR44.63303967
4EPHA24.55230085
5SIK14.54407208
6TAOK33.01872688
7TESK22.99940179
8ERBB42.98668426
9INSRR2.77505276
10TESK12.40825212
11MST1R2.33281259
12STK242.27193928
13MAP2K42.26474519
14PKN22.11604138
15MAPK111.96403021
16FLT31.84997867
17TRIB31.84461785
18PAK41.84305826
19ACVR1B1.80558194
20TYK21.73240222
21EPHB21.72544481
22NME21.71898486
23PIK3CG1.67798990
24FRK1.59907718
25LMTK21.59138402
26WNK41.59062738
27LATS11.58546967
28PRPF4B1.57762178
29PRKG21.55481885
30PTK61.55269733
31MAP3K21.53379585
32ABL21.49117329
33DAPK21.41833144
34GRK61.36594899
35NEK91.35126363
36ARAF1.33787651
37EEF2K1.30437588
38KDR1.29044093
39JAK21.27326479
40PDGFRA1.27237498
41ZAP701.26200094
42TBK11.22902224
43MAP3K101.18662218
44SMG11.15059936
45MAP3K71.13730371
46FGFR21.13664494
47PRKAA21.13114904
48PIM21.10722361
49DDR21.08960689
50ERBB21.08845129
51MAP2K31.08360803
52PINK11.07567289
53MAP3K111.02189045
54JAK11.00700034
55MAPK40.97506762
56MAP3K140.96903259
57MST40.96378091
58STK390.94391915
59MAP3K30.93727184
60PRKCZ0.91066469
61MET0.90967321
62ILK0.90559889
63MUSK0.90093370
64MAPK150.89185951
65STK38L0.86131130
66CDK60.84549607
67MYLK0.84082890
68NTRK10.83721270
69STK380.83559242
70EPHB10.82464206
71MAP3K120.81523551
72MAP2K60.80547050
73RPS6KA20.79622689
74TTN0.78840713
75DYRK1B0.78719335
76MAPK120.77380127
77BRAF0.76806307
78PRKACG0.76106879
79CAMK2G0.73202444
80RIPK10.72811280
81PRKCI0.72491161
82LIMK10.71133819
83SCYL20.70893871
84IRAK30.70656686
85CCNB10.70014294
86CSK0.68475905
87GSK3A0.67942045
88PRKAA10.67473898
89EPHA30.66917480
90STK160.66252556
91MOS0.65491340
92TIE10.62134832
93MAP3K80.61320395
94PDGFRB0.59413288
95IKBKE0.58355682
96PTK20.57848652
97MAP3K50.56855397
98PDPK10.56423870
99RPS6KC10.55760561
100RPS6KL10.55760561
101CSF1R0.54664593
102SGK30.52996007
103GRK10.52881993
104CAMK1D0.52623990
105PBK0.52452420
106TGFBR20.51632172
107TAOK20.51613326
108MAPK70.50717030
109PRKCQ0.50714775
110CDK40.50455690
111ICK0.48212214
112JAK30.47040750
113FGFR30.46419003
114MAP2K20.44680938
115SRC0.44462649
116MAP2K10.44169287
117AKT20.43957368
118PRKD20.42621559
119CSNK1G10.42485822
120RPS6KA60.41411517
121MAP3K60.39111091
122IGF1R0.38467059
123PRKCG0.36560043
124LRRK20.36110210
125MTOR0.35944399
126WNK10.35813361
127FGR0.35413160
128CDC42BPA0.35016915
129RET0.34154195
130PDK10.33915547
131MAP3K130.32467188
132PAK10.32119097
133SGK20.31862297
134TAOK10.31753199
135MAP3K10.31483751
136EGFR0.31265340
137AURKA0.30966580
138PKN10.30639478
139CAMK40.30280028
140AKT30.29734522
141EPHA40.29362725
142BMX0.29333514
143STK100.28828721
144PRKCA0.25593769
145MELK0.24689356
146PDK30.22734601
147PDK40.22734601
148MAPKAPK30.20983522
149ABL10.20898090
150SGK4940.19209216
151SGK2230.19209216
152LATS20.18794479
153CSNK1G20.18021921
154MAPKAPK20.17917497
155MAPK30.17903394
156IRAK10.17795189
157STK30.17341729

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.51340826
2Nitrogen metabolism_Homo sapiens_hsa009103.56798675
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.45358307
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.35489113
5* Arginine biosynthesis_Homo sapiens_hsa002202.91288291
6Complement and coagulation cascades_Homo sapiens_hsa046102.76281525
7Tryptophan metabolism_Homo sapiens_hsa003802.71477393
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.61603404
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.59369947
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.55425043
11Fatty acid degradation_Homo sapiens_hsa000712.47788961
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.35080923
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.25695373
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.12989317
15Butanoate metabolism_Homo sapiens_hsa006502.09160844
16Peroxisome_Homo sapiens_hsa041462.06012142
17Chemical carcinogenesis_Homo sapiens_hsa052041.94651806
18Histidine metabolism_Homo sapiens_hsa003401.93653709
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.92647011
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.90936628
21PPAR signaling pathway_Homo sapiens_hsa033201.87317083
22Propanoate metabolism_Homo sapiens_hsa006401.86476602
23Caffeine metabolism_Homo sapiens_hsa002321.83717570
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.77419079
25Fatty acid metabolism_Homo sapiens_hsa012121.76090359
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.75529286
27Staphylococcus aureus infection_Homo sapiens_hsa051501.73864412
28Retinol metabolism_Homo sapiens_hsa008301.70902294
29beta-Alanine metabolism_Homo sapiens_hsa004101.69514314
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.68465020
31Selenocompound metabolism_Homo sapiens_hsa004501.59843666
32Phenylalanine metabolism_Homo sapiens_hsa003601.57293989
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54167219
34Bile secretion_Homo sapiens_hsa049761.50577401
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50324778
36Tyrosine metabolism_Homo sapiens_hsa003501.43797599
37Sulfur metabolism_Homo sapiens_hsa009201.38477271
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.36420568
39Pyruvate metabolism_Homo sapiens_hsa006201.36065434
40Fat digestion and absorption_Homo sapiens_hsa049751.34745487
41Folate biosynthesis_Homo sapiens_hsa007901.32841475
42Starch and sucrose metabolism_Homo sapiens_hsa005001.32569434
43Fatty acid elongation_Homo sapiens_hsa000621.28406303
44* 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.20592436
45ABC transporters_Homo sapiens_hsa020101.19244680
46Steroid biosynthesis_Homo sapiens_hsa001001.19045435
47* Biosynthesis of amino acids_Homo sapiens_hsa012301.15623077
48Carbon metabolism_Homo sapiens_hsa012001.13941669
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.07134534
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.04391237
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03490981
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01386977
53Vitamin B6 metabolism_Homo sapiens_hsa007501.00002028
54Arginine and proline metabolism_Homo sapiens_hsa003300.99918212
55Sulfur relay system_Homo sapiens_hsa041220.99665442
56Vitamin digestion and absorption_Homo sapiens_hsa049770.97724151
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92442838
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86302961
59Lysine degradation_Homo sapiens_hsa003100.79658022
60One carbon pool by folate_Homo sapiens_hsa006700.78016412
61Other glycan degradation_Homo sapiens_hsa005110.77526481
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72702701
63Glutathione metabolism_Homo sapiens_hsa004800.71037431
64Glycerolipid metabolism_Homo sapiens_hsa005610.69775845
65Protein digestion and absorption_Homo sapiens_hsa049740.63451072
66Pentose phosphate pathway_Homo sapiens_hsa000300.62797815
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54656113
68Fatty acid biosynthesis_Homo sapiens_hsa000610.52190008
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48027023
70* Metabolic pathways_Homo sapiens_hsa011000.46999251
71Pertussis_Homo sapiens_hsa051330.46439516
72Prion diseases_Homo sapiens_hsa050200.35761825
73Galactose metabolism_Homo sapiens_hsa000520.34764262
74Fructose and mannose metabolism_Homo sapiens_hsa000510.32180774
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28537986
76Linoleic acid metabolism_Homo sapiens_hsa005910.25365932
77N-Glycan biosynthesis_Homo sapiens_hsa005100.24324273
78Sphingolipid metabolism_Homo sapiens_hsa006000.23117636
79Insulin resistance_Homo sapiens_hsa049310.22314614
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.20557031
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.18983486
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17045119
83Glucagon signaling pathway_Homo sapiens_hsa049220.07037202
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.02195576
85AMPK signaling pathway_Homo sapiens_hsa041520.01305510
86Amoebiasis_Homo sapiens_hsa05146-0.2435000
87Ether lipid metabolism_Homo sapiens_hsa00565-0.2332603
88Bladder cancer_Homo sapiens_hsa05219-0.2296668
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1938889
90Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1914616
91Mineral absorption_Homo sapiens_hsa04978-0.1895340
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1874475
93Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1792665
94Hepatitis C_Homo sapiens_hsa05160-0.1637507
95Regulation of autophagy_Homo sapiens_hsa04140-0.1555476
96Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1542267
97Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1509136
98African trypanosomiasis_Homo sapiens_hsa05143-0.1306539
99Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1300818
100Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1274241
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1265461
102Insulin signaling pathway_Homo sapiens_hsa04910-0.1175602
103Notch signaling pathway_Homo sapiens_hsa04330-0.0906903
104Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0898767
105Renin-angiotensin system_Homo sapiens_hsa04614-0.0601650
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0251368
107Lysosome_Homo sapiens_hsa04142-0.0212125
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0062343
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603-0.0007779

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