NAGK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the N-acetylhexosamine kinase family. The encoded protein catalyzes the conversion of N-acetyl-D-glucosamine to N-acetyl-D-glucosamine 6-phosphate, and is the major mammalian enzyme which recovers amino sugars. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.54126959
2negative regulation of cell killing (GO:0031342)5.54126959
3positive regulation of gamma-delta T cell activation (GO:0046645)5.48898336
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.21590538
5GMP metabolic process (GO:0046037)5.11224906
6short-term memory (GO:0007614)5.07331236
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.03124608
8positive regulation by organism of defense response of other organism involved in symbiotic interact5.03124608
9modulation by symbiont of host immune response (GO:0052553)5.03124608
10positive regulation by symbiont of host defense response (GO:0052509)5.03124608
11modulation by symbiont of host defense response (GO:0052031)5.03124608
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.03124608
13neuronal action potential propagation (GO:0019227)4.90094642
14antigen processing and presentation of endogenous antigen (GO:0019883)4.78050629
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.70497468
16neutrophil activation involved in immune response (GO:0002283)4.68111896
17detection of other organism (GO:0098543)4.66576622
18negative regulation of interleukin-12 production (GO:0032695)4.65650944
19macrophage activation involved in immune response (GO:0002281)4.61445200
20immunoglobulin mediated immune response (GO:0016064)4.54606458
21response to peptidoglycan (GO:0032494)4.54177064
22detection of bacterium (GO:0016045)4.50409939
23negative regulation of heart rate (GO:0010459)4.46908156
24presynaptic membrane assembly (GO:0097105)4.42007788
25negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)4.36613406
26antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.32485305
27mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.17673002
28regulation of B cell receptor signaling pathway (GO:0050855)4.17576670
29detection of external biotic stimulus (GO:0098581)4.00382417
30regulation of pigment cell differentiation (GO:0050932)3.93022187
31postsynaptic membrane organization (GO:0001941)3.92902635
32type I interferon signaling pathway (GO:0060337)3.92552495
33cellular response to type I interferon (GO:0071357)3.92552495
34response to type I interferon (GO:0034340)3.91006785
35regulation of interferon-beta biosynthetic process (GO:0045357)3.88723704
36regulation of gamma-delta T cell activation (GO:0046643)3.85348266
37detection of molecule of bacterial origin (GO:0032490)3.82427178
38interferon-gamma-mediated signaling pathway (GO:0060333)3.79397539
39melanin metabolic process (GO:0006582)3.77022874
40positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.75735463
41presynaptic membrane organization (GO:0097090)3.73088835
42regulation of mast cell degranulation (GO:0043304)3.66024618
43microglial cell activation (GO:0001774)3.63396286
44positive regulation of dendritic spine development (GO:0060999)3.63206697
45androgen biosynthetic process (GO:0006702)3.61428142
46neutrophil activation (GO:0042119)3.57819343
47cellular extravasation (GO:0045123)3.53258484
48response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.49563043
49response to host immune response (GO:0052572)3.49563043
50respiratory burst (GO:0045730)3.49191256
51facial nerve structural organization (GO:0021612)3.48428770
52positive regulation of mast cell activation (GO:0033005)3.48020486
53negative regulation of lymphocyte mediated immunity (GO:0002707)3.47514683
54detection of biotic stimulus (GO:0009595)3.47040306
55negative regulation of leukocyte chemotaxis (GO:0002689)3.46950370
56granulocyte activation (GO:0036230)3.46675486
57leukocyte aggregation (GO:0070486)3.45546382
58response to folic acid (GO:0051593)3.41718487
59defense response to protozoan (GO:0042832)3.40269768
60positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.40128928
61positive regulation of dendritic spine morphogenesis (GO:0061003)3.38594050
62myeloid cell activation involved in immune response (GO:0002275)3.37751318
63regulation of mast cell activation involved in immune response (GO:0033006)3.37294239
64positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.37153055
65regulation of antigen processing and presentation (GO:0002577)3.36422588
66macrophage activation (GO:0042116)3.36351121
67regulation of mast cell activation (GO:0033003)3.36192031
68B cell mediated immunity (GO:0019724)3.36084189
69regulation of dendritic cell antigen processing and presentation (GO:0002604)3.35169359
70negative regulation of leukocyte mediated immunity (GO:0002704)3.35164052
71cranial nerve morphogenesis (GO:0021602)3.34514193
72positive regulation of antigen processing and presentation (GO:0002579)3.34150142
73endothelium development (GO:0003158)3.34038915
74regulation of myeloid leukocyte mediated immunity (GO:0002886)3.32841615
75neuron cell-cell adhesion (GO:0007158)3.32482711
76positive regulation of protein homodimerization activity (GO:0090073)3.31284078
77regulation of T cell tolerance induction (GO:0002664)3.30064338
78positive regulation of synaptic transmission, GABAergic (GO:0032230)3.23713510
79melanin biosynthetic process (GO:0042438)3.22142592
80cAMP catabolic process (GO:0006198)3.20921032
81regulation of leukocyte degranulation (GO:0043300)3.20735671
82negative regulation of T cell mediated immunity (GO:0002710)3.20629384
83entrainment of circadian clock by photoperiod (GO:0043153)3.19743130
84respiratory electron transport chain (GO:0022904)3.19605474
85response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.18509710
86response to host (GO:0075136)3.18509710
87response to host defenses (GO:0052200)3.18509710
88regulation of relaxation of muscle (GO:1901077)3.17396372
89B cell receptor signaling pathway (GO:0050853)3.17370216
90regulation of cell communication by electrical coupling (GO:0010649)3.17315248
91positive regulation of synapse assembly (GO:0051965)3.15983314
92response to muramyl dipeptide (GO:0032495)3.14206921
93electron transport chain (GO:0022900)3.13338652
94positive regulation of mast cell activation involved in immune response (GO:0033008)3.12204890
95positive regulation of mast cell degranulation (GO:0043306)3.12204890
96response to protozoan (GO:0001562)3.11889450
97regulation of gamma-delta T cell differentiation (GO:0045586)3.11331052
98protein localization to cilium (GO:0061512)3.09839314
99regulation of tolerance induction (GO:0002643)3.08170972
100lipopolysaccharide-mediated signaling pathway (GO:0031663)3.07234938
101cyclic nucleotide catabolic process (GO:0009214)3.06367194
102T-helper 1 type immune response (GO:0042088)3.01281723
103ATP synthesis coupled proton transport (GO:0015986)3.00866886
104energy coupled proton transport, down electrochemical gradient (GO:0015985)3.00866886
105tolerance induction (GO:0002507)2.99421903
106entrainment of circadian clock (GO:0009649)2.98853335
107positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.98641778
108mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.97120229
109positive thymic T cell selection (GO:0045059)2.96759670
110regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.96234284
111negative regulation of cytokine production involved in immune response (GO:0002719)2.96002790
112negative regulation of innate immune response (GO:0045824)2.95563257
113positive regulation of interferon-alpha production (GO:0032727)2.95390967
114regulation of cardiac muscle cell contraction (GO:0086004)2.95344170
115regulation of interferon-alpha production (GO:0032647)2.94961474
116positive regulation of cellular amide metabolic process (GO:0034250)2.93297877
117positive regulation of type 2 immune response (GO:0002830)2.92178783
118positive regulation of membrane potential (GO:0045838)2.91492864
119production of molecular mediator involved in inflammatory response (GO:0002532)2.91371603
120ionotropic glutamate receptor signaling pathway (GO:0035235)2.91268511
121germinal center formation (GO:0002467)2.90881994
122NIK/NF-kappaB signaling (GO:0038061)2.90565074
123regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.90500320
124protein localization to synapse (GO:0035418)2.89722877
125T cell migration (GO:0072678)2.88502595
126protein heterotetramerization (GO:0051290)2.87752512
127cellular response to interferon-gamma (GO:0071346)2.87070348
128antigen processing and presentation via MHC class Ib (GO:0002475)2.86962308
129cranial nerve structural organization (GO:0021604)2.85454825
130negative regulation of interleukin-6 production (GO:0032715)2.85084980
131mannosylation (GO:0097502)2.84933548
132regulation of T cell mediated cytotoxicity (GO:0001914)2.84500327
133sympathetic nervous system development (GO:0048485)2.84159391
134regulation of T-helper 2 cell differentiation (GO:0045628)2.82727798
135enteric nervous system development (GO:0048484)2.81586924
136positive regulation of B cell differentiation (GO:0045579)2.81094885
137regulation of regulated secretory pathway (GO:1903305)2.76986647
138membrane assembly (GO:0071709)2.76754941
139neutrophil mediated immunity (GO:0002446)2.76061208
140leukocyte migration involved in inflammatory response (GO:0002523)2.75460159
141positive regulation of cellular amine metabolic process (GO:0033240)2.74876896
142positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.74153226
143secondary metabolite biosynthetic process (GO:0044550)2.71695615
144myeloid dendritic cell differentiation (GO:0043011)2.71425339
145regulation of type 2 immune response (GO:0002828)2.71389590
146positive regulation of amino acid transport (GO:0051957)2.71369479
147respiratory chain complex IV assembly (GO:0008535)2.70522176
148regulation of B cell differentiation (GO:0045577)2.70111791
149response to interferon-gamma (GO:0034341)2.69910819
150myeloid leukocyte activation (GO:0002274)2.69123475
151negative regulation of calcium ion transport into cytosol (GO:0010523)2.69014666
152positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.68342366
153positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.67550516
154chaperone-mediated protein transport (GO:0072321)2.66484422
155photoperiodism (GO:0009648)2.65461104
156GTP biosynthetic process (GO:0006183)2.64450530
157central nervous system neuron axonogenesis (GO:0021955)2.63066045
158axon ensheathment in central nervous system (GO:0032291)2.62678208
159central nervous system myelination (GO:0022010)2.62678208
160DNA ligation (GO:0006266)2.61781998
161righting reflex (GO:0060013)2.60366288
162protein neddylation (GO:0045116)2.59720003
163negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.59710960
164aldehyde catabolic process (GO:0046185)2.58398813
165regulation of protein kinase A signaling (GO:0010738)2.50896201
166regulation of synapse assembly (GO:0051963)2.48533778
167regulation of ruffle assembly (GO:1900027)2.41081780
168neuronal action potential (GO:0019228)2.40438352
169positive regulation of action potential (GO:0045760)2.39722607
170vocalization behavior (GO:0071625)2.39327607
171negative regulation of synaptic transmission, GABAergic (GO:0032229)2.37386742
172cytochrome complex assembly (GO:0017004)2.37229649
173positive regulation of steroid hormone secretion (GO:2000833)2.35714552
174serotonin receptor signaling pathway (GO:0007210)2.35632323
175peripheral nervous system neuron development (GO:0048935)2.35425666
176negative regulation of cation channel activity (GO:2001258)2.33763903
177regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.33698337
178regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.33474128
179regulation of voltage-gated calcium channel activity (GO:1901385)2.31651536
180protein complex biogenesis (GO:0070271)2.29880242
181generation of neurons (GO:0048699)2.29549309
182glutamate receptor signaling pathway (GO:0007215)2.28564265
183positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.27630982
184long-chain fatty acid biosynthetic process (GO:0042759)2.27627814
185negative regulation of norepinephrine secretion (GO:0010700)2.27490014
186deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.26964785
187lymphoid progenitor cell differentiation (GO:0002320)2.26251002
188axon development (GO:0061564)2.25001839
189positive regulation of protein kinase C signaling (GO:0090037)2.24910876
190negative regulation of calcium ion transmembrane transport (GO:1903170)2.24895651
191negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.24895651
192oligodendrocyte differentiation (GO:0048709)2.24109948
193detection of temperature stimulus involved in sensory perception (GO:0050961)2.24019027
194detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.24019027
195regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.23807530
196regulation of synaptic transmission, GABAergic (GO:0032228)2.23406481
197developmental pigmentation (GO:0048066)2.23030016
198negative regulation of execution phase of apoptosis (GO:1900118)2.22810759
199response to pain (GO:0048265)2.22633832
200omega-hydroxylase P450 pathway (GO:0097267)10.0723484

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.39335409
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.31656530
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.69223930
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.21271198
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.14567095
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.93229611
7GBX2_23144817_ChIP-Seq_PC3_Human3.72063105
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.42349382
9IRF8_27001747_Chip-Seq_BMDM_Mouse3.37543311
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.30995861
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.27343288
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.18717199
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.95759163
14JARID2_20064375_ChIP-Seq_MESCs_Mouse2.87566126
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.68194157
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.55276160
17SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.51770717
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.50089857
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.48848776
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.43921945
21VDR_21846776_ChIP-Seq_THP-1_Human2.42712288
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.42001859
23VDR_24763502_ChIP-Seq_THP-1_Human2.41280345
24SPI1_23547873_ChIP-Seq_NB4_Human2.39261821
25JARID2_20075857_ChIP-Seq_MESCs_Mouse2.38606124
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.38366059
27EED_16625203_ChIP-ChIP_MESCs_Mouse2.36641181
28BMI1_23680149_ChIP-Seq_NPCS_Mouse2.35976417
29SPI1_23127762_ChIP-Seq_K562_Human2.34676236
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.34512372
31TAF15_26573619_Chip-Seq_HEK293_Human2.30865166
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.28879335
33MYB_21317192_ChIP-Seq_ERMYB_Mouse2.27923174
34CDX2_19796622_ChIP-Seq_MESCs_Mouse2.27397156
35RNF2_18974828_ChIP-Seq_MESCs_Mouse2.24277580
36EZH2_18974828_ChIP-Seq_MESCs_Mouse2.24277580
37RUNX_20019798_ChIP-Seq_JUKART_Human2.20849850
38* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.17303126
39SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.15467837
40SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.15005844
41STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.14883527
42STAT4_19710469_ChIP-ChIP_TH1__Mouse2.13014444
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.12796040
44Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.99883370
45SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.99635553
46EZH2_27294783_Chip-Seq_ESCs_Mouse1.99231278
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.97026297
48SUZ12_27294783_Chip-Seq_ESCs_Mouse1.95212120
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.94694265
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94645985
51MAF_26560356_Chip-Seq_TH1_Human1.94030433
52* RUNX1_22412390_ChIP-Seq_EML_Mouse1.93719085
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.91269886
54MTF2_20144788_ChIP-Seq_MESCs_Mouse1.90743000
55VDR_24787735_ChIP-Seq_THP-1_Human1.90724377
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.86208651
57MYB_26560356_Chip-Seq_TH2_Human1.85713443
58SCL_19346495_ChIP-Seq_HPC-7_Human1.85376148
59BRD4_27068464_Chip-Seq_AML-cells_Mouse1.80685436
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.78603033
61KDM2B_26808549_Chip-Seq_SUP-B15_Human1.78297007
62THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.75235439
63UTX_26944678_Chip-Seq_JUKART_Human1.72846707
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70949921
65* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.70913385
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70330542
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67283806
68LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.64970925
69RNF2_27304074_Chip-Seq_ESCs_Mouse1.60447173
70* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.54442297
71P300_19829295_ChIP-Seq_ESCs_Human1.51727579
72MYB_26560356_Chip-Seq_TH1_Human1.51217671
73MAF_26560356_Chip-Seq_TH2_Human1.50923167
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.47816500
75KDM2B_26808549_Chip-Seq_DND41_Human1.46455615
76PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43889448
77LXR_22292898_ChIP-Seq_THP-1_Human1.43164880
78GATA1_19941827_ChIP-Seq_MEL_Mouse1.42935604
79PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.40096444
80GATA3_27048872_Chip-Seq_THYMUS_Human1.39809534
81GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.39063779
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38674052
83RNF2_27304074_Chip-Seq_NSC_Mouse1.37430647
84CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.37341446
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36764125
86TCF7_22412390_ChIP-Seq_EML_Mouse1.36329807
87WT1_19549856_ChIP-ChIP_CCG9911_Human1.36071872
88* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.35439677
89ELK3_25401928_ChIP-Seq_HUVEC_Human1.35217432
90AR_21572438_ChIP-Seq_LNCaP_Human1.34987054
91MYC_22102868_ChIP-Seq_BL_Human1.33757135
92FLI1_27457419_Chip-Seq_LIVER_Mouse1.33079449
93PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32315653
94PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31584315
95REST_21632747_ChIP-Seq_MESCs_Mouse1.30152854
96BCL6_27268052_Chip-Seq_Bcells_Human1.28940423
97STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28558336
98CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28159771
99SMAD4_21799915_ChIP-Seq_A2780_Human1.27963574
100ER_23166858_ChIP-Seq_MCF-7_Human1.27538785
101RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26486784
102NANOG_18555785_Chip-Seq_ESCs_Mouse1.26184914
103VDR_22108803_ChIP-Seq_LS180_Human1.23510712
104EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22776779
105POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22605327
106LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22605176
107SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21542953
108TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21517851
109PU_27001747_Chip-Seq_BMDM_Mouse1.21146982
110CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20158044
111SMAD3_21741376_ChIP-Seq_EPCs_Human1.19464918
112GATA3_26560356_Chip-Seq_TH2_Human1.19248111
113SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18865542
114KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18071324
115P53_22387025_ChIP-Seq_ESCs_Mouse1.17563708
116GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16819597
117BCOR_27268052_Chip-Seq_Bcells_Human1.16348005
118SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15544530
119GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14729402
120PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14389116
121* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12278979
122RUNX1_27457419_Chip-Seq_LIVER_Mouse1.12234775
123KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11740102
124E2F1_18555785_Chip-Seq_ESCs_Mouse1.11682645
125SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11474096
126SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11206011
127NMYC_18555785_Chip-Seq_ESCs_Mouse1.11178628
128VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.10075174
129UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09736593
130TP53_18474530_ChIP-ChIP_U2OS_Human1.09674761
131P300_18555785_Chip-Seq_ESCs_Mouse1.08670120
132GATA2_21666600_ChIP-Seq_HMVEC_Human1.08453761
133IGF1R_20145208_ChIP-Seq_DFB_Human1.07964120
134RUNX2_22187159_ChIP-Seq_PCA_Human1.07827401
135NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07415400
136TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07134248
137STAT3_18555785_Chip-Seq_ESCs_Mouse1.07087964
138PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06011881
139EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05866633
140NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.05410918
141TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03534666
142GATA1_19941826_ChIP-Seq_K562_Human1.03079087
143SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02596840
144ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01544910
145CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.00937783
146GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00898344
147MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00318066
148KDM2B_26808549_Chip-Seq_REH_Human1.00161108
149CMYC_18555785_Chip-Seq_ESCs_Mouse0.99931756
150SOX2_18555785_Chip-Seq_ESCs_Mouse0.99386737
151NFE2_27457419_Chip-Seq_LIVER_Mouse0.97983111
152ELF1_20517297_ChIP-Seq_JURKAT_Human0.97879157
153STAT1_20625510_ChIP-Seq_HELA_Human0.95100304
154OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95011820
155EGR1_19374776_ChIP-ChIP_THP-1_Human0.94891550
156AR_25329375_ChIP-Seq_VCAP_Human0.94864954
157EZH2_27294783_Chip-Seq_NPCs_Mouse0.94361669
158CDX2_20551321_ChIP-Seq_CACO-2_Human0.93594414
159NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.93427775
160LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92877771
161GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92440035
162FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92097918
163KLF4_18555785_Chip-Seq_ESCs_Mouse0.91775603
164TP53_20018659_ChIP-ChIP_R1E_Mouse0.91381480
165SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90948798
166* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90032956
167NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.89700523
168* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88636365
169PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88352410
170SMAD_19615063_ChIP-ChIP_OVARY_Human0.87560578
171CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87433346
172CTCF_27219007_Chip-Seq_Bcells_Human0.87363960
173TAL1_26923725_Chip-Seq_HPCs_Mouse0.87079498
174CTCF_18555785_Chip-Seq_ESCs_Mouse0.86803163
175EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.86294291
176TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85590985
177FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.85115480
178ESRRB_18555785_Chip-Seq_ESCs_Mouse0.84067095
179SA1_27219007_Chip-Seq_ERYTHROID_Human0.83881731
180* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.83842864
181KDM2B_26808549_Chip-Seq_JURKAT_Human0.83770845
182REST_18959480_ChIP-ChIP_MESCs_Mouse0.83647027
183PU1_27457419_Chip-Seq_LIVER_Mouse0.82658924
184OCT4_18555785_Chip-Seq_ESCs_Mouse0.82582400
185CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.82511798
186CRX_20693478_ChIP-Seq_RETINA_Mouse0.82310294
187TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81974606
188SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.81277709
189CTCF_27219007_Chip-Seq_ERYTHROID_Human0.79584923
190DNAJC2_21179169_ChIP-ChIP_NT2_Human0.79553295
191CTCF_26484167_Chip-Seq_Bcells_Mouse0.78984834
192EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.78003362
193ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.76689508
194GATA1_22025678_ChIP-Seq_K562_Human0.75910924
195P300_27268052_Chip-Seq_Bcells_Human0.75685226

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.99208279
2MP0005409_darkened_coat_color4.65876124
3MP0009379_abnormal_foot_pigmentation4.37038112
4MP0001835_abnormal_antigen_presentation3.86062167
5MP0003436_decreased_susceptibility_to3.85333127
6MP0001188_hyperpigmentation3.69159721
7MP0003880_abnormal_central_pattern3.60983343
8MP0006082_CNS_inflammation3.23353615
9MP0001986_abnormal_taste_sensitivity3.22689387
10MP0005671_abnormal_response_to3.16870919
11MP0002419_abnormal_innate_immunity3.09278714
12MP0001790_abnormal_immune_system3.06283740
13MP0005387_immune_system_phenotype3.06283740
14MP0009785_altered_susceptibility_to3.01036012
15MP0000372_irregular_coat_pigmentation2.95494044
16MP0000685_abnormal_immune_system2.95303845
17MP0005025_abnormal_response_to2.90566662
18MP0005000_abnormal_immune_tolerance2.90209202
19MP0001800_abnormal_humoral_immune2.89239155
20MP0008260_abnormal_autophagy2.84628440
21MP0002735_abnormal_chemical_nociception2.80677354
22MP0002876_abnormal_thyroid_physiology2.78762943
23MP0005058_abnormal_lysosome_morphology2.68407952
24MP0002452_abnormal_antigen_presenting2.62652898
25MP0003172_abnormal_lysosome_physiology2.62424754
26MP0002723_abnormal_immune_serum2.61440973
27MP0006276_abnormal_autonomic_nervous2.58032216
28MP0001968_abnormal_touch/_nociception2.57809564
29MP0000015_abnormal_ear_pigmentation2.54865603
30MP0004381_abnormal_hair_follicle2.50607552
31MP0006292_abnormal_olfactory_placode2.49713678
32MP0002420_abnormal_adaptive_immunity2.40478820
33MP0001819_abnormal_immune_cell2.38831197
34MP0003724_increased_susceptibility_to2.33466430
35MP0003300_gastrointestinal_ulcer2.29458947
36MP0001533_abnormal_skeleton_physiology2.15692521
37MP0003191_abnormal_cellular_cholesterol2.12209500
38MP0001970_abnormal_pain_threshold1.91415008
39MP0002405_respiratory_system_inflammati1.89970151
40MP0002736_abnormal_nociception_after1.89557528
41MP0004270_analgesia1.87505587
42MP0005464_abnormal_platelet_physiology1.85602699
43MP0002638_abnormal_pupillary_reflex1.84938375
44MP0001845_abnormal_inflammatory_respons1.84166290
45MP0002734_abnormal_mechanical_nocicepti1.80854578
46MP0009764_decreased_sensitivity_to1.78490179
47MP0002272_abnormal_nervous_system1.76593031
48MP0009745_abnormal_behavioral_response1.74579232
49MP0000716_abnormal_immune_system1.73210651
50MP0002733_abnormal_thermal_nociception1.72582276
51MP0010155_abnormal_intestine_physiology1.70863698
52MP0005174_abnormal_tail_pigmentation1.68337254
53MP0005171_absent_coat_pigmentation1.67348655
54MP0002751_abnormal_autonomic_nervous1.67199130
55MP0003183_abnormal_peptide_metabolism1.63507120
56MP0003763_abnormal_thymus_physiology1.63140640
57MP0010386_abnormal_urinary_bladder1.62652784
58MP0004510_myositis1.60894153
59MP0002064_seizures1.60515345
60MP0005310_abnormal_salivary_gland1.59281739
61MP0000604_amyloidosis1.58370995
62MP0003635_abnormal_synaptic_transmissio1.57631225
63MP0008469_abnormal_protein_level1.57418294
64MP0004947_skin_inflammation1.55446116
65MP0009333_abnormal_splenocyte_physiolog1.55301100
66MP0003075_altered_response_to1.55202632
67MP0002067_abnormal_sensory_capabilities1.54701068
68MP0002398_abnormal_bone_marrow1.54623229
69MP0001905_abnormal_dopamine_level1.53458999
70MP0009278_abnormal_bone_marrow1.53364431
71MP0009840_abnormal_foam_cell1.49772484
72MP0000343_altered_response_to1.48862425
73MP0003303_peritoneal_inflammation1.47354785
74MP0002557_abnormal_social/conspecific_i1.41474014
75MP0003690_abnormal_glial_cell1.39469088
76MP0002998_abnormal_bone_remodeling1.39255733
77MP0000689_abnormal_spleen_morphology1.35661188
78MP0004883_abnormal_blood_vessel1.32674350
79MP0000858_altered_metastatic_potential1.31186263
80MP0004742_abnormal_vestibular_system1.30579752
81MP0002429_abnormal_blood_cell1.29372652
82MP0005084_abnormal_gallbladder_morpholo1.27188996
83MP0003866_abnormal_defecation1.26852744
84MP0002184_abnormal_innervation1.25992702
85MP0002572_abnormal_emotion/affect_behav1.25617996
86MP0000465_gastrointestinal_hemorrhage1.25224696
87MP0009046_muscle_twitch1.23970584
88MP0002722_abnormal_immune_system1.23964112
89MP0004272_abnormal_basement_membrane1.21669389
90MP0001486_abnormal_startle_reflex1.21471574
91MP0005165_increased_susceptibility_to1.20846794
92MP0003868_abnormal_feces_composition1.19443571
93MP0005257_abnormal_intraocular_pressure1.18000629
94MP0003879_abnormal_hair_cell1.16669574
95MP0004859_abnormal_synaptic_plasticity1.13912169
96MP0001529_abnormal_vocalization1.10589219
97MP0005451_abnormal_body_composition1.10505345
98MP0004142_abnormal_muscle_tone1.10416058
99MP0002177_abnormal_outer_ear1.10278974
100MP0001440_abnormal_grooming_behavior1.09444855
101MP0003806_abnormal_nucleotide_metabolis1.09444477
102MP0005166_decreased_susceptibility_to1.08491508
103MP0005397_hematopoietic_system_phenotyp1.07817660
104MP0001545_abnormal_hematopoietic_system1.07817660
105MP0008569_lethality_at_weaning1.07693055
106MP0005423_abnormal_somatic_nervous1.06520581
107MP0001853_heart_inflammation1.06514905
108MP0005408_hypopigmentation1.05853410
109MP0002938_white_spotting1.03916528
110MP0005379_endocrine/exocrine_gland_phen1.03512629
111MP0000569_abnormal_digit_pigmentation1.03480563
112MP0005164_abnormal_response_to1.02400066
113MP0005390_skeleton_phenotype0.99883293
114MP0003448_altered_tumor_morphology0.99804329
115MP0000778_abnormal_nervous_system0.99439033
116MP0002229_neurodegeneration0.99403848
117MP0002132_abnormal_respiratory_system0.98151525
118MP0003938_abnormal_ear_development0.97820938
119MP0000026_abnormal_inner_ear0.97533790
120MP0000681_abnormal_thyroid_gland0.97330178
121MP0001963_abnormal_hearing_physiology0.96299110
122MP0002138_abnormal_hepatobiliary_system0.95611142
123MP0001664_abnormal_digestion0.92444724
124MP0001851_eye_inflammation0.91448626
125MP0003329_amyloid_beta_deposits0.90466803
126MP0005595_abnormal_vascular_smooth0.88863162
127MP0000703_abnormal_thymus_morphology0.88616682
128MP0000566_synostosis0.88422128
129MP0000920_abnormal_myelination0.87124067
130MP0003279_aneurysm0.85788225
131MP0009763_increased_sensitivity_to0.85594248
132MP0001501_abnormal_sleep_pattern0.85408515
133MP0002095_abnormal_skin_pigmentation0.84451138
134MP0000631_abnormal_neuroendocrine_gland0.84400238
135MP0001958_emphysema0.83261973
136MP0002882_abnormal_neuron_morphology0.83149923
137MP0002933_joint_inflammation0.82792192
138MP0002752_abnormal_somatic_nervous0.82140052
139MP0008789_abnormal_olfactory_epithelium0.81886914
140MP0005167_abnormal_blood-brain_barrier0.80104124
141MP0002148_abnormal_hypersensitivity_rea0.79646995
142MP0002063_abnormal_learning/memory/cond0.79523331
143MP0000613_abnormal_salivary_gland0.79295011
144MP0005551_abnormal_eye_electrophysiolog0.79245630
145MP0003315_abnormal_perineum_morphology0.78852744
146MP0001873_stomach_inflammation0.77058837
147MP0000371_diluted_coat_color0.74942935
148MP0001663_abnormal_digestive_system0.73494112
149MP0002160_abnormal_reproductive_system0.73066583
150MP0003795_abnormal_bone_structure0.72821320
151MP0002066_abnormal_motor_capabilities/c0.72294752
152MP0003011_delayed_dark_adaptation0.70349938
153MP0001661_extended_life_span0.70329892
154MP0005075_abnormal_melanosome_morpholog0.70272196
155MP0006054_spinal_hemorrhage0.69166018
156MP0003959_abnormal_lean_body0.68786941
157MP0000249_abnormal_blood_vessel0.68083265
158MP0000955_abnormal_spinal_cord0.67028901
159MP0008004_abnormal_stomach_pH0.66747793
160MP0005394_taste/olfaction_phenotype0.66541904
161MP0005499_abnormal_olfactory_system0.66541904
162MP0003045_fibrosis0.65196302
163MP0001542_abnormal_bone_strength0.64666569
164MP0003634_abnormal_glial_cell0.64643240
165MP0002254_reproductive_system_inflammat0.64450225
166MP0008874_decreased_physiological_sensi0.63503777
167MP0002277_abnormal_respiratory_mucosa0.62454599
168MP0003091_abnormal_cell_migration0.62283656
169MP0009765_abnormal_xenobiotic_induced0.61606126
170MP0005381_digestive/alimentary_phenotyp0.61017244
171MP0002332_abnormal_exercise_endurance0.60202106
172MP0002102_abnormal_ear_morphology0.60149095
173MP0002166_altered_tumor_susceptibility0.59398905
174MP0001984_abnormal_olfaction0.58067007
175MP0003828_pulmonary_edema0.57899921
176MP0000230_abnormal_systemic_arterial0.57830460
177MP0000049_abnormal_middle_ear0.57702901
178MP0005410_abnormal_fertilization0.55888645
179MP0001502_abnormal_circadian_rhythm0.55779879
180MP0004145_abnormal_muscle_electrophysio0.54837311
181MP0002693_abnormal_pancreas_physiology0.53537765
182MP0005319_abnormal_enzyme/_coenzyme0.52785366
183MP0003453_abnormal_keratinocyte_physiol0.50573354
184MP0002653_abnormal_ependyma_morphology0.46755232

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.86968506
2Recurrent bacterial skin infections (HP:0005406)5.65397673
3Recurrent abscess formation (HP:0002722)5.46110744
4Agitation (HP:0000713)5.44744610
5Abnormality of macrophages (HP:0004311)5.44706621
6Abnormality of glycolipid metabolism (HP:0010969)5.20683586
7Abnormality of liposaccharide metabolism (HP:0010968)5.20683586
8Abnormality of glycosphingolipid metabolism (HP:0004343)5.20683586
9Myositis (HP:0100614)4.90405169
10Type I transferrin isoform profile (HP:0003642)4.87551103
11Orchitis (HP:0100796)4.66270433
12Retrobulbar optic neuritis (HP:0100654)4.44902062
13Optic neuritis (HP:0100653)4.44902062
14Recurrent gram-negative bacterial infections (HP:0005420)4.40032268
15Mediastinal lymphadenopathy (HP:0100721)4.35031523
16Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.24683213
17Hypothermia (HP:0002045)4.05151681
18Reduced antithrombin III activity (HP:0001976)4.00884820
19Elevated erythrocyte sedimentation rate (HP:0003565)3.98931284
20Restlessness (HP:0000711)3.97302480
21Recurrent fungal infections (HP:0002841)3.94848364
22Increased hepatocellular lipid droplets (HP:0006565)3.83709881
23Ulnar claw (HP:0001178)3.81972334
24Recurrent skin infections (HP:0001581)3.80836897
25Hypercortisolism (HP:0001578)3.76131600
26Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.73158951
27Renal Fanconi syndrome (HP:0001994)3.72794153
28Increased cerebral lipofuscin (HP:0011813)3.71243612
29Chronic mucocutaneous candidiasis (HP:0002728)3.58247226
30Recurrent cutaneous fungal infections (HP:0011370)3.58247226
31Focal motor seizures (HP:0011153)3.56984635
32Sensory axonal neuropathy (HP:0003390)3.55972522
33Abnormal delayed hypersensitivity skin test (HP:0002963)3.53596707
34Meningitis (HP:0001287)3.53498982
35Gastrointestinal infarctions (HP:0005244)3.50401916
36Acute necrotizing encephalopathy (HP:0006965)3.45215113
37Optic disc pallor (HP:0000543)3.41422355
383-Methylglutaconic aciduria (HP:0003535)3.41203493
39Mitochondrial inheritance (HP:0001427)3.39863576
40Dysostosis multiplex (HP:0000943)3.35291478
41Vasculitis (HP:0002633)3.32403936
42Aplasia/Hypoplasia of the fovea (HP:0008060)3.30672227
43Hypoplasia of the fovea (HP:0007750)3.30672227
44Nonprogressive disorder (HP:0003680)3.28861780
45Lipid accumulation in hepatocytes (HP:0006561)3.24589127
46Pulmonary infiltrates (HP:0002113)3.21501748
47Systemic lupus erythematosus (HP:0002725)3.16555423
48Increased IgE level (HP:0003212)3.14443409
49Myokymia (HP:0002411)3.14209396
50Loss of speech (HP:0002371)3.13865159
51Abnormality of magnesium homeostasis (HP:0004921)3.13231954
52Spontaneous hematomas (HP:0007420)3.12441001
53Abnormality of secondary sexual hair (HP:0009888)3.11300899
54Abnormality of the axillary hair (HP:0100134)3.11300899
55Increased neuronal autofluorescent lipopigment (HP:0002074)3.06950952
56Encephalitis (HP:0002383)3.04760018
57Keratoconjunctivitis sicca (HP:0001097)3.04286965
58Gingivitis (HP:0000230)3.04012055
59Hemoptysis (HP:0002105)3.03992991
60Urticaria (HP:0001025)3.03318209
61Attenuation of retinal blood vessels (HP:0007843)3.02546717
62Abnormal protein glycosylation (HP:0012346)3.00141563
63Abnormal glycosylation (HP:0012345)3.00141563
64Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.00141563
65Abnormal protein N-linked glycosylation (HP:0012347)3.00141563
66Hepatocellular necrosis (HP:0001404)2.89025274
67Pustule (HP:0200039)2.88175471
68Keratoconjunctivitis (HP:0001096)2.86081686
69Progressive macrocephaly (HP:0004481)2.85379750
70Dry hair (HP:0011359)2.82858467
71Hypomagnesemia (HP:0002917)2.82363693
72Lower limb hyperreflexia (HP:0002395)2.76714185
73Abnormal mitochondria in muscle tissue (HP:0008316)2.76673834
74Abnormality of polysaccharide metabolism (HP:0011012)2.71983620
75Abnormality of glycosaminoglycan metabolism (HP:0004371)2.71983620
76Abnormality of mucopolysaccharide metabolism (HP:0011020)2.71983620
77Recurrent viral infections (HP:0004429)2.71925127
78Cellulitis (HP:0100658)2.71487146
79Abnormality of the fovea (HP:0000493)2.63849702
80Exertional dyspnea (HP:0002875)2.62033443
81Disinhibition (HP:0000734)2.60548154
82Testicular atrophy (HP:0000029)2.57819457
83Autoimmune thrombocytopenia (HP:0001973)2.57590533
84Amyloidosis (HP:0011034)2.57048883
85T lymphocytopenia (HP:0005403)2.56620177
86Acute encephalopathy (HP:0006846)2.56017788
87Increased IgM level (HP:0003496)2.54640949
88Abnormality of T cell number (HP:0011839)2.53744192
89Abnormality of renal resorption (HP:0011038)2.50854909
90Abnormal sex determination (HP:0012244)2.50339221
91Sex reversal (HP:0012245)2.50339221
92Increased CSF lactate (HP:0002490)2.49271138
93Chest pain (HP:0100749)2.47686899
94Urinary glycosaminoglycan excretion (HP:0003541)2.45005636
95Mucopolysacchariduria (HP:0008155)2.45005636
96Mutism (HP:0002300)2.44644605
97Leukocytosis (HP:0001974)2.44521314
98Purpura (HP:0000979)2.42505081
99Vacuolated lymphocytes (HP:0001922)2.39257681
100Inflammation of the large intestine (HP:0002037)2.39121314
101Episodic fever (HP:0001954)2.38612442
102Gastrointestinal stroma tumor (HP:0100723)2.38475320
103Adrenal overactivity (HP:0002717)2.36784613
104Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.35308525
105Microvesicular hepatic steatosis (HP:0001414)2.34323110
106Dynein arm defect of respiratory motile cilia (HP:0012255)2.34309802
107Absent/shortened dynein arms (HP:0200106)2.34309802
108Peritonitis (HP:0002586)2.34207781
109Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.34132219
110Panhypogammaglobulinemia (HP:0003139)2.32817216
111Abnormal ciliary motility (HP:0012262)2.32244017
112Striae distensae (HP:0001065)2.32112871
113Hepatic necrosis (HP:0002605)2.31998035
114Glomerulonephritis (HP:0000099)2.31746248
115Abnormality of T cells (HP:0002843)2.30285873
116Prolonged bleeding time (HP:0003010)2.29342233
117Hypergammaglobulinemia (HP:0010702)2.28850104
118Petechiae (HP:0000967)2.28735647
119Gastrointestinal inflammation (HP:0004386)2.26127878
120Parakeratosis (HP:0001036)2.25253909
121Steppage gait (HP:0003376)2.24246258
122Pulmonary embolism (HP:0002204)2.24204137
123Thyroid-stimulating hormone excess (HP:0002925)2.24128604
124Increased intramyocellular lipid droplets (HP:0012240)2.23153000
125Abnormality of calcium-phosphate metabolism (HP:0100530)2.22320132
126Hypochromic anemia (HP:0001931)2.21511641
127Lymphopenia (HP:0001888)2.21022305
128Gingival bleeding (HP:0000225)2.20623597
129Abnormality of the pleura (HP:0002103)2.20268625
130Osteomyelitis (HP:0002754)2.19566992
131Short tibia (HP:0005736)2.19544741
132Agammaglobulinemia (HP:0004432)2.19339158
133Recurrent bronchitis (HP:0002837)2.18703277
134Aplasia/hypoplasia of the uterus (HP:0008684)2.18456928
135Increased serum ferritin (HP:0003281)2.17658162
136Anorexia (HP:0002039)2.17334499
137Recurrent pneumonia (HP:0006532)2.16287292
138Abnormality of the peritoneum (HP:0002585)2.15549729
139Peripheral hypomyelination (HP:0007182)2.15039067
140Restrictive lung disease (HP:0002091)2.14984267
141Anxiety (HP:0000739)2.14592277
142Colitis (HP:0002583)2.13671025
143Epistaxis (HP:0000421)2.13601199
144Arterial thrombosis (HP:0004420)2.13393114
145Hematochezia (HP:0002573)2.12411320
146Basal ganglia calcification (HP:0002135)2.11826610
147Gangrene (HP:0100758)2.11410638
148Hypochromic microcytic anemia (HP:0004840)2.10708237
149Cerebral edema (HP:0002181)2.10664956
150Progressive external ophthalmoplegia (HP:0000590)2.08415908
151Cortical visual impairment (HP:0100704)2.07059141
152Aplasia/Hypoplasia of the tibia (HP:0005772)2.07033847
153Hepatosplenomegaly (HP:0001433)2.07022508
154Recurrent sinusitis (HP:0011108)2.04009413
155Abnormality of cells of the lymphoid lineage (HP:0012140)2.03341009
156IgM deficiency (HP:0002850)2.03320043
157Gaze-evoked nystagmus (HP:0000640)2.03014569
158Atonic seizures (HP:0010819)2.02814465
159Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.02395071
160Abnormality of T cell physiology (HP:0011840)2.01876203
161Progressive inability to walk (HP:0002505)2.01028314
162Absent rod-and cone-mediated responses on ERG (HP:0007688)1.98786314
163Recurrent lower respiratory tract infections (HP:0002783)1.98034032
164Aplasia/Hypoplasia of the macula (HP:0008059)1.97950559
165Sepsis (HP:0100806)1.97727839
166Renal tubular dysfunction (HP:0000124)1.96707534
167Progressive neurologic deterioration (HP:0002344)1.96170821
168Medial flaring of the eyebrow (HP:0010747)1.94537545
169Abnormality of iron homeostasis (HP:0011031)1.94022749
170Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.93122551
171Acne (HP:0001061)1.92576094
172Febrile seizures (HP:0002373)1.92421754
173Granulocytopenia (HP:0001913)1.92107305
174Abnormal respiratory motile cilium physiology (HP:0012261)1.91556911
175Hyperphosphaturia (HP:0003109)1.91138583
176Stomatitis (HP:0010280)1.89684835
177Congenital glaucoma (HP:0001087)1.87099559
178Impaired proprioception (HP:0010831)1.84857529
179Exercise intolerance (HP:0003546)1.84283453
180Focal seizures (HP:0007359)1.83858934
181Stage 5 chronic kidney disease (HP:0003774)1.83780200
182Chronic obstructive pulmonary disease (HP:0006510)1.83264593
183Obstructive lung disease (HP:0006536)1.83264593
184Blue irides (HP:0000635)1.80097073
185Psychosis (HP:0000709)1.79531484
186Late onset (HP:0003584)1.77653067
187Depression (HP:0000716)1.77022108
188Capillary hemangiomas (HP:0005306)1.76956005
189Abnormal urine phosphate concentration (HP:0012599)1.76918885
190Gait imbalance (HP:0002141)1.75208346
191Aplasia/Hypoplasia affecting the retina (HP:0008061)1.74522753
192Patchy hypopigmentation of hair (HP:0011365)1.73893533
193Abnormal respiratory epithelium morphology (HP:0012253)1.73674731
194Abnormal respiratory motile cilium morphology (HP:0005938)1.73674731
195Limb dystonia (HP:0002451)1.71906691
196Increased muscle lipid content (HP:0009058)1.71646554

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.24319374
2CASK4.47927268
3MAPK134.13135991
4TNIK4.03937264
5MAP4K13.60546617
6TYK23.10457875
7ERN12.77297372
8FES2.63629728
9MKNK22.47910516
10MUSK2.45927311
11TBK12.03342820
12IRAK32.02783752
13MAP2K32.02479587
14JAK32.01171789
15IKBKE1.96498562
16MAPK121.95850182
17GRK51.95756520
18MAP3K131.93590428
19MAP3K111.90559946
20TEC1.87950255
21ZAP701.86961685
22TXK1.82375657
23TLK11.78290939
24MAP3K121.75695816
25MST41.67993651
26GRK61.67402094
27TAOK31.63885719
28STK161.61698511
29RIPK41.58107826
30MAP3K31.57637879
31PIM21.53334937
32CSF1R1.52979156
33EPHB11.52318242
34STK391.50094582
35GRK71.49291104
36TAOK11.48381092
37JAK11.47279580
38HCK1.46539499
39PRPF4B1.41182058
40IRAK41.40658652
41IKBKB1.39387024
42ARAF1.39381812
43MAPK111.38914605
44TESK21.36472807
45MAP2K71.35945624
46SIK31.28760769
47IRAK21.27035284
48CAMK11.26097662
49TGFBR21.25059826
50ADRBK21.22259464
51PRKD21.20948441
52LCK1.20729031
53AKT31.16990316
54MKNK11.16642851
55FER1.15845165
56NTRK31.14457630
57JAK21.11697526
58CDC42BPA1.07594620
59MAPK151.06368376
60NME11.06323806
61ITK1.03321765
62BMPR1B1.02835202
63BLK1.01395939
64FGR1.00553113
65NLK0.99690563
66UHMK10.96205473
67CAMKK20.95597041
68IRAK10.95281196
69CAMK2B0.94555052
70EIF2AK30.93957842
71MARK20.91534441
72OXSR10.89610464
73YES10.87957385
74MARK30.86133099
75INSRR0.85795185
76MAPKAPK50.85243636
77BMPR20.80874645
78KSR20.78412206
79MAPK70.77943996
80BRAF0.77504915
81MYLK0.76749860
82CDK190.75902526
83SRPK10.75124886
84WNK40.74549885
85CSNK1G30.74516955
86PDK10.74515063
87TAOK20.74485667
88CDK140.73027717
89MAPK40.72197262
90CLK10.72171359
91CSNK1G10.71907085
92MOS0.70255877
93PDPK10.69643863
94HIPK20.68210932
95EPHA30.67707726
96MAP3K60.65685919
97GRK10.65192383
98FYN0.63539604
99LIMK10.62804762
100PTK2B0.62202444
101PRKCQ0.60917636
102DYRK1B0.58486743
103CAMK2A0.58094188
104EPHB20.56635217
105PRKCE0.56409529
106FGFR40.56371767
107TRIB30.56274033
108EIF2AK20.55221100
109PRKACA0.54999503
110MARK10.52913578
111ADRBK10.52652411
112NTRK10.52629618
113CHUK0.52595880
114DYRK20.51463834
115CSK0.50996004
116CAMK2D0.50867079
117MAP2K20.50587150
118STK100.49550513
119PIK3CG0.49331847
120TNK20.47005803
121RPS6KC10.46849100
122RPS6KL10.46849100
123DAPK20.46290751
124PTK60.45300394
125RPS6KA60.45260519
126CSNK1A1L0.45197290
127BTK0.44073685
128CSNK1G20.43670541
129LYN0.43390049
130TIE10.42632817
131MAP3K70.42331660
132PKN10.41661007
133ABL10.41595305
134MAP3K50.41317522
135VRK10.41093446
136PRKG10.40286768
137PNCK0.40049184
138CAMKK10.39562414
139SIK10.39144204
140RPS6KA20.38468483
141MAP2K60.38099391
142PRKCD0.37594800
143MAP2K40.37426818
144DDR20.36632427
145CDK50.36489186
146MATK0.36072120
147CAMK2G0.36059165
148PRKCZ0.35463033
149FGFR30.35279683
150PRKD10.34971861
151KIT0.34803285
152SGK4940.34055857
153SGK2230.34055857
154SYK0.33940749
155MINK10.33688378
156MAP3K140.33671365
157MAP3K10.33645113
158NEK60.33270531
159PRKG20.32944994
160SIK20.32934963
161EPHA40.32647806
162LRRK20.32643628
163MAPKAPK20.32201366
164PIM10.30517954
165DYRK1A0.30379129
166PRKCH0.30060181

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.39148351
2Parkinsons disease_Homo sapiens_hsa050123.21935291
3Staphylococcus aureus infection_Homo sapiens_hsa051503.19546452
4Leishmaniasis_Homo sapiens_hsa051402.84860846
5Osteoclast differentiation_Homo sapiens_hsa043802.77449251
6Alzheimers disease_Homo sapiens_hsa050102.76857036
7Ribosome_Homo sapiens_hsa030102.69715085
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.64556746
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.63842139
10Protein export_Homo sapiens_hsa030602.61650469
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.45251991
12Phototransduction_Homo sapiens_hsa047442.27286691
13Tuberculosis_Homo sapiens_hsa051522.25607459
14Huntingtons disease_Homo sapiens_hsa050162.25127410
15Type I diabetes mellitus_Homo sapiens_hsa049402.20281876
16Primary immunodeficiency_Homo sapiens_hsa053402.17683470
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.15080632
18Toll-like receptor signaling pathway_Homo sapiens_hsa046202.11790664
19Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.11759001
20Nicotine addiction_Homo sapiens_hsa050332.10934964
21Antigen processing and presentation_Homo sapiens_hsa046122.00090118
22Arachidonic acid metabolism_Homo sapiens_hsa005901.97621984
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.96657795
24Collecting duct acid secretion_Homo sapiens_hsa049661.89686683
25B cell receptor signaling pathway_Homo sapiens_hsa046621.89216057
26Morphine addiction_Homo sapiens_hsa050321.82891965
27Taste transduction_Homo sapiens_hsa047421.76028679
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.74224966
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.71667808
30Viral myocarditis_Homo sapiens_hsa054161.71496032
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.70950484
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.69190420
33Serotonergic synapse_Homo sapiens_hsa047261.66596718
34NOD-like receptor signaling pathway_Homo sapiens_hsa046211.64038152
35Cardiac muscle contraction_Homo sapiens_hsa042601.56028963
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.55823746
37Toxoplasmosis_Homo sapiens_hsa051451.54656473
38Sphingolipid metabolism_Homo sapiens_hsa006001.54408215
39Glutamatergic synapse_Homo sapiens_hsa047241.52466295
40Fatty acid elongation_Homo sapiens_hsa000621.51797353
41Ether lipid metabolism_Homo sapiens_hsa005651.50273869
42Influenza A_Homo sapiens_hsa051641.49446095
43Chemokine signaling pathway_Homo sapiens_hsa040621.45075480
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.43049986
45Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.42504459
46Measles_Homo sapiens_hsa051621.41144251
47Other glycan degradation_Homo sapiens_hsa005111.40046602
48Vibrio cholerae infection_Homo sapiens_hsa051101.39433885
49GABAergic synapse_Homo sapiens_hsa047271.30396358
50TNF signaling pathway_Homo sapiens_hsa046681.29785361
51Synaptic vesicle cycle_Homo sapiens_hsa047211.26240953
52Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.26117023
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.26000119
54T cell receptor signaling pathway_Homo sapiens_hsa046601.25993774
55Herpes simplex infection_Homo sapiens_hsa051681.25986339
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.25366701
57Legionellosis_Homo sapiens_hsa051341.24740267
58Rheumatoid arthritis_Homo sapiens_hsa053231.24408526
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.21511110
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.19028685
61RNA polymerase_Homo sapiens_hsa030201.16086156
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.12790425
63Salmonella infection_Homo sapiens_hsa051321.12570365
64Long-term depression_Homo sapiens_hsa047301.05319117
65Jak-STAT signaling pathway_Homo sapiens_hsa046301.05128375
66Acute myeloid leukemia_Homo sapiens_hsa052211.04903434
67Salivary secretion_Homo sapiens_hsa049701.03820099
68Linoleic acid metabolism_Homo sapiens_hsa005911.03613567
69Steroid hormone biosynthesis_Homo sapiens_hsa001401.02839786
70SNARE interactions in vesicular transport_Homo sapiens_hsa041301.00455812
71Circadian entrainment_Homo sapiens_hsa047130.99745951
72Hepatitis C_Homo sapiens_hsa051600.99083878
73Regulation of autophagy_Homo sapiens_hsa041400.98643296
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98001892
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.97406193
76Insulin secretion_Homo sapiens_hsa049110.96247562
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95857038
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.93167247
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.91453994
80Hepatitis B_Homo sapiens_hsa051610.90516237
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90383835
82Cholinergic synapse_Homo sapiens_hsa047250.89720842
83Sulfur metabolism_Homo sapiens_hsa009200.89691894
84Phagosome_Homo sapiens_hsa041450.89291819
85Shigellosis_Homo sapiens_hsa051310.84190326
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.83780246
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82529676
88N-Glycan biosynthesis_Homo sapiens_hsa005100.81150298
89Apoptosis_Homo sapiens_hsa042100.79107431
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78890699
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77082889
92Platelet activation_Homo sapiens_hsa046110.77026125
93Purine metabolism_Homo sapiens_hsa002300.75476711
94Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74348100
95Cocaine addiction_Homo sapiens_hsa050300.73161901
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68502665
97Axon guidance_Homo sapiens_hsa043600.68396981
98Calcium signaling pathway_Homo sapiens_hsa040200.67804130
99Amphetamine addiction_Homo sapiens_hsa050310.67693314
100Dopaminergic synapse_Homo sapiens_hsa047280.67512721
101Endocytosis_Homo sapiens_hsa041440.66645183
102Proteasome_Homo sapiens_hsa030500.66072168
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.65614915
104Pertussis_Homo sapiens_hsa051330.63881031
105Malaria_Homo sapiens_hsa051440.63823003
106Epstein-Barr virus infection_Homo sapiens_hsa051690.62651898
107Olfactory transduction_Homo sapiens_hsa047400.61647132
108VEGF signaling pathway_Homo sapiens_hsa043700.61020923
109Renin secretion_Homo sapiens_hsa049240.59951321
110Histidine metabolism_Homo sapiens_hsa003400.59270631
111Melanogenesis_Homo sapiens_hsa049160.58606996
112Ovarian steroidogenesis_Homo sapiens_hsa049130.57769718
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.57293350
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57132104
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.56352083
116Long-term potentiation_Homo sapiens_hsa047200.55506754
117Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54890606
118Asthma_Homo sapiens_hsa053100.54254637
119Wnt signaling pathway_Homo sapiens_hsa043100.54003900
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52955910
121* Metabolic pathways_Homo sapiens_hsa011000.52587438
122Thyroid cancer_Homo sapiens_hsa052160.52548250
123Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52355775
124Pancreatic secretion_Homo sapiens_hsa049720.52290347
125Mineral absorption_Homo sapiens_hsa049780.50629643
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50138752
127Notch signaling pathway_Homo sapiens_hsa043300.49872891
128Prolactin signaling pathway_Homo sapiens_hsa049170.49794684
129Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49451760
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.49377471
131Autoimmune thyroid disease_Homo sapiens_hsa053200.49018854
132Amoebiasis_Homo sapiens_hsa051460.47506249
133Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46795467
134Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.45579634
135cAMP signaling pathway_Homo sapiens_hsa040240.45220457
136Hematopoietic cell lineage_Homo sapiens_hsa046400.43149714
137Steroid biosynthesis_Homo sapiens_hsa001000.42993347
138Pancreatic cancer_Homo sapiens_hsa052120.42876392
139GnRH signaling pathway_Homo sapiens_hsa049120.41526912
140Non-small cell lung cancer_Homo sapiens_hsa052230.41461514
141Adipocytokine signaling pathway_Homo sapiens_hsa049200.40936689
142Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40017051
143Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38918161
144Graft-versus-host disease_Homo sapiens_hsa053320.38703267
145Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38559596
146Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38065786
147Dorso-ventral axis formation_Homo sapiens_hsa043200.37884165
148African trypanosomiasis_Homo sapiens_hsa051430.37812009
149Renal cell carcinoma_Homo sapiens_hsa052110.37384060
150HTLV-I infection_Homo sapiens_hsa051660.36169613
151Allograft rejection_Homo sapiens_hsa053300.35376519
152Gastric acid secretion_Homo sapiens_hsa049710.35203621
153Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33276676
154Complement and coagulation cascades_Homo sapiens_hsa046100.33052602
155Homologous recombination_Homo sapiens_hsa034400.31748911
156MAPK signaling pathway_Homo sapiens_hsa040100.31464694
157Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31086835
158Gap junction_Homo sapiens_hsa045400.30938228
159Glutathione metabolism_Homo sapiens_hsa004800.30916499
160Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30643899
161Lysosome_Homo sapiens_hsa041420.30533616
162Chronic myeloid leukemia_Homo sapiens_hsa052200.29634649
163Prion diseases_Homo sapiens_hsa050200.29179384
164Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28610654
165HIF-1 signaling pathway_Homo sapiens_hsa040660.27190109
166Glycerophospholipid metabolism_Homo sapiens_hsa005640.26955784
167FoxO signaling pathway_Homo sapiens_hsa040680.24648182
168Type II diabetes mellitus_Homo sapiens_hsa049300.24315436
169Viral carcinogenesis_Homo sapiens_hsa052030.23875245
170Choline metabolism in cancer_Homo sapiens_hsa052310.23829566
171Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22662240
172Rap1 signaling pathway_Homo sapiens_hsa040150.21420885

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