NAA50

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)4.98946591
2DNA unwinding involved in DNA replication (GO:0006268)4.97525159
3nuclear pore complex assembly (GO:0051292)4.90485858
4protein localization to kinetochore (GO:0034501)4.89463960
5folic acid-containing compound biosynthetic process (GO:0009396)4.61470206
6establishment of integrated proviral latency (GO:0075713)4.60522126
7mitotic nuclear envelope disassembly (GO:0007077)4.47539412
8cellular protein complex localization (GO:0034629)4.42274612
9mitotic metaphase plate congression (GO:0007080)4.41136206
10protein complex localization (GO:0031503)4.37149127
11IMP biosynthetic process (GO:0006188)4.27853703
12DNA replication initiation (GO:0006270)4.27477956
13mitotic chromosome condensation (GO:0007076)4.24099330
14membrane disassembly (GO:0030397)4.22904574
15nuclear envelope disassembly (GO:0051081)4.22904574
16IMP metabolic process (GO:0046040)4.22827095
17protein localization to chromosome, centromeric region (GO:0071459)4.12828840
18DNA strand elongation involved in DNA replication (GO:0006271)3.99087076
19DNA replication-dependent nucleosome assembly (GO:0006335)3.95038738
20DNA replication-dependent nucleosome organization (GO:0034723)3.95038738
21ribosome assembly (GO:0042255)3.92926302
22nucleobase biosynthetic process (GO:0046112)3.91253686
23regulation of translational termination (GO:0006449)3.91028382
24regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.84535840
25regulation of spindle organization (GO:0090224)3.76582275
26regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.76414844
27DNA strand elongation (GO:0022616)3.75019746
28metaphase plate congression (GO:0051310)3.73991029
29DNA replication checkpoint (GO:0000076)3.72378460
30mitotic sister chromatid segregation (GO:0000070)3.69555565
31purine nucleobase biosynthetic process (GO:0009113)3.68540555
32sister chromatid segregation (GO:0000819)3.66795678
33pore complex assembly (GO:0046931)3.63457738
34formation of translation preinitiation complex (GO:0001731)3.50988991
35chromatin remodeling at centromere (GO:0031055)3.50123187
36non-recombinational repair (GO:0000726)3.45563781
37double-strand break repair via nonhomologous end joining (GO:0006303)3.45563781
38attachment of spindle microtubules to kinetochore (GO:0008608)3.45208119
39regulation of sister chromatid cohesion (GO:0007063)3.43819373
40telomere maintenance via semi-conservative replication (GO:0032201)3.43723236
41CENP-A containing nucleosome assembly (GO:0034080)3.41345350
42kinetochore organization (GO:0051383)3.41331664
43heterochromatin organization (GO:0070828)3.40561773
44DNA replication-independent nucleosome assembly (GO:0006336)3.40203605
45DNA replication-independent nucleosome organization (GO:0034724)3.40203605
46nuclear envelope organization (GO:0006998)3.39718081
47regulation of centriole replication (GO:0046599)3.39414397
48establishment of viral latency (GO:0019043)3.37327175
49positive regulation of chromosome segregation (GO:0051984)3.34577169
50DNA geometric change (GO:0032392)3.33879274
51DNA duplex unwinding (GO:0032508)3.33360101
52establishment of chromosome localization (GO:0051303)3.32948533
53regulation of mitotic spindle organization (GO:0060236)3.30177331
54mitotic recombination (GO:0006312)3.28971099
55telomere maintenance via recombination (GO:0000722)3.25483062
56folic acid metabolic process (GO:0046655)3.17791507
57dosage compensation (GO:0007549)3.16109209
58* mitotic sister chromatid cohesion (GO:0007064)3.15891174
59chromatin assembly or disassembly (GO:0006333)3.14352689
60DNA topological change (GO:0006265)3.13240357
61regulation of centrosome cycle (GO:0046605)3.12861517
62nucleobase-containing small molecule interconversion (GO:0015949)3.10208222
63DNA synthesis involved in DNA repair (GO:0000731)3.08344938
64mRNA stabilization (GO:0048255)3.07402122
65RNA stabilization (GO:0043489)3.07402122
66protein localization to chromosome (GO:0034502)3.07149376
67ribosome biogenesis (GO:0042254)3.06543080
68regulation of chromosome segregation (GO:0051983)3.06169262
69positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.03528061
70positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.03528061
71positive regulation of mitotic sister chromatid separation (GO:1901970)3.03528061
72meiotic chromosome segregation (GO:0045132)3.02032581
73histone exchange (GO:0043486)3.01620011
74regulation of mitotic sister chromatid separation (GO:0010965)2.98947374
75regulation of sister chromatid segregation (GO:0033045)2.98947374
76spindle checkpoint (GO:0031577)2.98909628
77regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.98641257
783-UTR-mediated mRNA stabilization (GO:0070935)2.97442444
79histone-serine phosphorylation (GO:0035404)2.95185116
80DNA ligation (GO:0006266)2.95164499
81maturation of SSU-rRNA (GO:0030490)2.91876917
82regulation of RNA export from nucleus (GO:0046831)2.90821377
83tetrahydrofolate metabolic process (GO:0046653)2.90575841
84mitotic G1 DNA damage checkpoint (GO:0031571)2.89840662
85translesion synthesis (GO:0019985)2.88914562
86regulation of mitotic metaphase/anaphase transition (GO:0030071)2.88429112
87chromosome segregation (GO:0007059)2.87260052
88negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.85210808
89ATP-dependent chromatin remodeling (GO:0043044)2.84822520
90somatic hypermutation of immunoglobulin genes (GO:0016446)2.84603784
91somatic diversification of immune receptors via somatic mutation (GO:0002566)2.84603784
92protein export from nucleus (GO:0006611)2.84499251
93spindle assembly checkpoint (GO:0071173)2.83985852
94negative regulation of DNA repair (GO:0045738)2.83394480
95telomere maintenance via telomere lengthening (GO:0010833)2.83060499
96negative regulation of chromosome segregation (GO:0051985)2.82549323
97regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.82245610
98mitotic spindle checkpoint (GO:0071174)2.80656391
99regulation of translational fidelity (GO:0006450)2.78204856
100mitotic spindle assembly checkpoint (GO:0007094)2.78174025
101DNA conformation change (GO:0071103)2.77729349
102negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.77684599
103negative regulation of sister chromatid segregation (GO:0033046)2.77684599
104negative regulation of mitotic sister chromatid separation (GO:2000816)2.77684599
105negative regulation of mitotic sister chromatid segregation (GO:0033048)2.77684599
106chromatin assembly (GO:0031497)2.77602428
107DNA packaging (GO:0006323)2.77511246
108postreplication repair (GO:0006301)2.75493095
109histone H2A monoubiquitination (GO:0035518)2.74003443
110protein K6-linked ubiquitination (GO:0085020)2.72959256
111negative regulation of mRNA metabolic process (GO:1903312)2.71711682
112pre-miRNA processing (GO:0031054)2.70940203
113chromosome condensation (GO:0030261)2.70462171
114negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.69998434
115G1/S transition of mitotic cell cycle (GO:0000082)2.69883258
116cell cycle G1/S phase transition (GO:0044843)2.69883258
117nucleotide-excision repair, DNA gap filling (GO:0006297)2.69414428
118regulation of helicase activity (GO:0051095)2.68706387
119mitotic G2/M transition checkpoint (GO:0044818)2.68013090
120negative regulation of histone methylation (GO:0031061)2.67964689
121RNA-dependent DNA replication (GO:0006278)2.67576876
122monoubiquitinated protein deubiquitination (GO:0035520)2.66996320
123negative regulation of RNA splicing (GO:0033119)2.65694655
124kinetochore assembly (GO:0051382)2.64856124
125regulation of mitotic sister chromatid segregation (GO:0033047)2.64394879

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.56918307
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.97417240
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.95733956
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.69806130
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.37923544
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.17617265
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.13132854
8AR_21909140_ChIP-Seq_LNCAP_Human2.92778748
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.68859872
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.49798005
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.32806768
12NELFA_20434984_ChIP-Seq_ESCs_Mouse2.29059829
13* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.25636111
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.17541440
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.17163444
16MYC_22102868_ChIP-Seq_BL_Human2.10908336
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.02424345
18XRN2_22483619_ChIP-Seq_HELA_Human1.93847368
19MYCN_18555785_ChIP-Seq_MESCs_Mouse1.89955124
20SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.85302405
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.84212427
22ETS1_20019798_ChIP-Seq_JURKAT_Human1.79370650
23EST1_17652178_ChIP-ChIP_JURKAT_Human1.79346089
24PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76192073
25ZFX_18555785_ChIP-Seq_MESCs_Mouse1.71679912
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.66172341
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.65082681
28DCP1A_22483619_ChIP-Seq_HELA_Human1.62662988
29VDR_23849224_ChIP-Seq_CD4+_Human1.61815239
30E2F1_18555785_ChIP-Seq_MESCs_Mouse1.60602485
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.57201441
32STAT3_1855785_ChIP-Seq_MESCs_Mouse1.54971481
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.52157884
34SALL1_21062744_ChIP-ChIP_HESCs_Human1.51101985
35KDM5A_27292631_Chip-Seq_BREAST_Human1.49919523
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.47677306
37TTF2_22483619_ChIP-Seq_HELA_Human1.45289984
38KLF4_18555785_ChIP-Seq_MESCs_Mouse1.45044603
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.44631276
40ELK1_19687146_ChIP-ChIP_HELA_Human1.43424026
41GABP_19822575_ChIP-Seq_HepG2_Human1.43260766
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.41642131
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.39616432
44JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.38932051
45ESR1_15608294_ChIP-ChIP_MCF-7_Human1.37845728
46ZNF263_19887448_ChIP-Seq_K562_Human1.36496500
47FOXP3_21729870_ChIP-Seq_TREG_Human1.34238571
48POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.33123830
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29896883
50CLOCK_20551151_ChIP-Seq_293T_Human1.29823808
51SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.29694700
52TFEB_21752829_ChIP-Seq_HELA_Human1.27189674
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26672754
54HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.23397924
55CIITA_25753668_ChIP-Seq_RAJI_Human1.20343769
56DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19789458
57HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17854093
58SOX17_20123909_ChIP-Seq_XEN_Mouse1.17009431
59E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16868414
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15921221
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14695299
62TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14555489
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13698361
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13489678
65ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12852604
66TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12769709
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10961828
68* ATF3_27146783_Chip-Seq_COLON_Human1.09747260
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06953281
70TP63_17297297_ChIP-ChIP_HaCaT_Human1.06829711
71CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06286984
72CHD1_26751641_Chip-Seq_LNCaP_Human1.06009391
73CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05412450
74RBPJ_22232070_ChIP-Seq_NCS_Mouse1.04281990
75NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.03322763
76TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.02854759
77SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.01947451
78NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.01398349
79TCF3_18692474_ChIP-Seq_MEFs_Mouse1.01205175
80PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.00683701
81VDR_21846776_ChIP-Seq_THP-1_Human1.00009123
82HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99261369
83KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.99015195
84KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.99015195
85KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.99015195
86MYB_21317192_ChIP-Seq_ERMYB_Mouse0.98273201
87CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97517770
88PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96247777
89ELF1_17652178_ChIP-ChIP_JURKAT_Human0.96227493
90BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94557901
91NANOG_21062744_ChIP-ChIP_HESCs_Human0.94441832
92TP63_19390658_ChIP-ChIP_HaCaT_Human0.94045107
93KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.93777924
94CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92646733
95THAP11_20581084_ChIP-Seq_MESCs_Mouse0.92480631
96ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92384819
97CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91058367
98FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.90851657
99SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.90448579
100SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.90448579
101MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.89329502
102NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.89270844
103GATA4_21415370_ChIP-Seq_HL-1_Mouse0.87675267
104ERG_20887958_ChIP-Seq_HPC-7_Mouse0.87506725
105POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.87035987
106TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87011839
107SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.86774117
108SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.86505183
109E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.85620749
110STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.85006349
111SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.84951885
112NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.84308666
113TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84305704
114BRD4_27068464_Chip-Seq_AML-cells_Mouse0.82622522
115ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.81147215
116KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.80905631
117EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.80662600
118ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.80036668
119CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.79979349
120HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.78986175
121SOX2_18555785_ChIP-Seq_MESCs_Mouse0.78050414

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.05385603
2MP0010094_abnormal_chromosome_stability3.55114902
3MP0004957_abnormal_blastocyst_morpholog3.54140713
4MP0003111_abnormal_nucleus_morphology3.43728523
5MP0003705_abnormal_hypodermis_morpholog3.11510396
6MP0003077_abnormal_cell_cycle3.03539740
7MP0010352_gastrointestinal_tract_polyps3.00852815
8MP0008057_abnormal_DNA_replication2.63587160
9MP0010307_abnormal_tumor_latency2.44959427
10MP0005076_abnormal_cell_differentiation2.24707456
11MP0008007_abnormal_cellular_replicative2.19437579
12MP0001730_embryonic_growth_arrest2.18415656
13MP0003123_paternal_imprinting2.17641026
14MP0009697_abnormal_copulation2.12979215
15MP0000350_abnormal_cell_proliferation2.11025023
16MP0002796_impaired_skin_barrier1.97605419
17MP0002396_abnormal_hematopoietic_system1.94180512
18MP0008932_abnormal_embryonic_tissue1.89290803
19MP0005451_abnormal_body_composition1.82478438
20MP0004197_abnormal_fetal_growth/weight/1.72789817
21MP0001672_abnormal_embryogenesis/_devel1.69658398
22MP0005380_embryogenesis_phenotype1.69658398
23MP0001697_abnormal_embryo_size1.68677180
24MP0003806_abnormal_nucleotide_metabolis1.66821394
25MP0008058_abnormal_DNA_repair1.62974267
26MP0000733_abnormal_muscle_development1.59754019
27MP0003984_embryonic_growth_retardation1.59316417
28MP0002088_abnormal_embryonic_growth/wei1.57869683
29MP0010234_abnormal_vibrissa_follicle1.57848797
30MP0004185_abnormal_adipocyte_glucose1.57502476
31MP0002086_abnormal_extraembryonic_tissu1.54681132
32MP0003567_abnormal_fetal_cardiomyocyte1.47329419
33MP0002084_abnormal_developmental_patter1.46755322
34MP0002080_prenatal_lethality1.45576136
35MP0002009_preneoplasia1.45127273
36MP0003566_abnormal_cell_adhesion1.43277420
37MP0009053_abnormal_anal_canal1.43221297
38MP0002877_abnormal_melanocyte_morpholog1.40283453
39MP0002085_abnormal_embryonic_tissue1.39921806
40MP0000750_abnormal_muscle_regeneration1.38102467
41MP0004808_abnormal_hematopoietic_stem1.37130315
42MP0000490_abnormal_crypts_of1.34935850
43MP0001661_extended_life_span1.33542715
44MP0006054_spinal_hemorrhage1.33400427
45MP0002019_abnormal_tumor_incidence1.26355227
46MP0000579_abnormal_nail_morphology1.24485414
47MP0003950_abnormal_plasma_membrane1.22869864
48MP0003221_abnormal_cardiomyocyte_apopto1.22516027
49MP0005023_abnormal_wound_healing1.12548698
50MP0001915_intracranial_hemorrhage1.11831944
51MP0009672_abnormal_birth_weight1.11322013
52MP0000749_muscle_degeneration1.11109040
53MP0010030_abnormal_orbit_morphology1.08460771
54MP0005397_hematopoietic_system_phenotyp1.06891373
55MP0001545_abnormal_hematopoietic_system1.06891373
56MP0000751_myopathy1.06528831
57MP0003718_maternal_effect1.05565688
58MP0001216_abnormal_epidermal_layer1.03642295
59MP0000313_abnormal_cell_death1.01337730
60MP0003786_premature_aging0.99147918
61MP0000762_abnormal_tongue_morphology0.96539770
62MP0008438_abnormal_cutaneous_collagen0.96202433
63MP0002269_muscular_atrophy0.94935915
64MP0000747_muscle_weakness0.94702949
65MP0002697_abnormal_eye_size0.94224983
66MP0005666_abnormal_adipose_tissue0.93362661
67MP0003890_abnormal_embryonic-extraembry0.92636401
68MP0000858_altered_metastatic_potential0.92395671
69MP0004233_abnormal_muscle_weight0.91878803
70MP0005330_cardiomyopathy0.91227250
71MP0004272_abnormal_basement_membrane0.91224801
72MP0003646_muscle_fatigue0.90499669
73MP0003300_gastrointestinal_ulcer0.89796791
74MP0010678_abnormal_skin_adnexa0.88683104
75MP0004036_abnormal_muscle_relaxation0.86569204
76MP0004087_abnormal_muscle_fiber0.85737675
77MP0001849_ear_inflammation0.84658684
78MP0006035_abnormal_mitochondrial_morpho0.83105209
79MP0009703_decreased_birth_body0.81461226
80MP0003303_peritoneal_inflammation0.81125279
81MP0005623_abnormal_meninges_morphology0.80945045
82MP0008877_abnormal_DNA_methylation0.79638530
83MP0005621_abnormal_cell_physiology0.79306678
84MP0000537_abnormal_urethra_morphology0.79302984
85MP0003448_altered_tumor_morphology0.77223283
86MP0002106_abnormal_muscle_physiology0.77159309
87MP0003937_abnormal_limbs/digits/tail_de0.76893241
88MP0000467_abnormal_esophagus_morphology0.76553765
89MP0000627_abnormal_mammary_gland0.76075468
90MP0008260_abnormal_autophagy0.74439481
91MP0005275_abnormal_skin_tensile0.73833405
92MP0004782_abnormal_surfactant_physiolog0.73710584
93MP0000759_abnormal_skeletal_muscle0.72815004
94MP0005384_cellular_phenotype0.72770406
95MP0002111_abnormal_tail_morphology0.72728789
96MP0003121_genomic_imprinting0.72420608
97MP0001727_abnormal_embryo_implantation0.71319778
98MP0004264_abnormal_extraembryonic_tissu0.70740022
99MP0003315_abnormal_perineum_morphology0.70595109
100MP0000428_abnormal_craniofacial_morphol0.70356641
101MP0003453_abnormal_keratinocyte_physiol0.69752753
102MP0000598_abnormal_liver_morphology0.69664755
103MP0003186_abnormal_redox_activity0.69446693
104MP0001243_abnormal_dermal_layer0.69248097
105MP0000377_abnormal_hair_follicle0.68502019
106MP0005501_abnormal_skin_physiology0.68419964
107MP0006036_abnormal_mitochondrial_physio0.67876151
108MP0009333_abnormal_splenocyte_physiolog0.67643912
109MP0000358_abnormal_cell_content/0.67033575
110MP0003656_abnormal_erythrocyte_physiolo0.67003453
111MP0002210_abnormal_sex_determination0.66867994
112MP0002092_abnormal_eye_morphology0.66828974
113MP0002060_abnormal_skin_morphology0.66163956
114MP0001881_abnormal_mammary_gland0.65929105
115MP0005187_abnormal_penis_morphology0.65804909
116MP0004084_abnormal_cardiac_muscle0.65697375
117MP0001293_anophthalmia0.64469827
118MP0009278_abnormal_bone_marrow0.64449783
119MP0003941_abnormal_skin_development0.64067489
120MP0010630_abnormal_cardiac_muscle0.63439110
121MP0001119_abnormal_female_reproductive0.63259260
122MP0002006_tumorigenesis0.62458146
123MP0000703_abnormal_thymus_morphology0.62249295
124MP0001145_abnormal_male_reproductive0.61953864
125MP0005266_abnormal_metabolism0.61860597
126MP0000689_abnormal_spleen_morphology0.61575929
127MP0002722_abnormal_immune_system0.61412803

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)3.70717628
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.62735341
3Nemaline bodies (HP:0003798)3.46731178
4Calcaneovalgus deformity (HP:0001848)3.40397034
5Birth length less than 3rd percentile (HP:0003561)3.38721558
6Pelvic girdle muscle weakness (HP:0003749)3.33888136
7Ulnar deviation of the wrist (HP:0003049)3.26337074
8Abnormality of the calcaneus (HP:0008364)3.19682882
9Deformed tarsal bones (HP:0008119)3.17563334
10Progressive external ophthalmoplegia (HP:0000590)3.03949863
11Type 1 muscle fiber predominance (HP:0003803)2.97385460
12Microvesicular hepatic steatosis (HP:0001414)2.94694239
13Shoulder girdle muscle weakness (HP:0003547)2.86629079
14Ependymoma (HP:0002888)2.84778822
15Abnormality of the hip-girdle musculature (HP:0001445)2.81544029
16Abnormality of the musculature of the pelvis (HP:0001469)2.81544029
17Distal arthrogryposis (HP:0005684)2.78323047
18Exercise-induced muscle cramps (HP:0003710)2.72202786
19Increased connective tissue (HP:0009025)2.67687572
20Colon cancer (HP:0003003)2.67528907
21Nephroblastoma (Wilms tumor) (HP:0002667)2.64779665
22Breast hypoplasia (HP:0003187)2.55034820
23Selective tooth agenesis (HP:0001592)2.54706985
24Protrusio acetabuli (HP:0003179)2.53594534
25Oral leukoplakia (HP:0002745)2.51891175
26Embryonal renal neoplasm (HP:0011794)2.50400190
27Ankle contracture (HP:0006466)2.48278749
28Rhabdomyosarcoma (HP:0002859)2.41971132
29Increased density of long bones (HP:0006392)2.38190458
30Abnormality of chromosome stability (HP:0003220)2.36253298
31Microglossia (HP:0000171)2.33932239
32Deep philtrum (HP:0002002)2.33745169
33Myopathic facies (HP:0002058)2.32240993
34Chromsome breakage (HP:0040012)2.31598509
35Ankyloglossia (HP:0010296)2.31246345
36Round ear (HP:0100830)2.31043442
37Biliary tract neoplasm (HP:0100574)2.30746450
38Termporal pattern (HP:0011008)2.25860166
39Insidious onset (HP:0003587)2.25860166
40Deviation of the thumb (HP:0009603)2.25303012
41Rhabdomyolysis (HP:0003201)2.25175336
42Agnosia (HP:0010524)2.25168238
43Medulloblastoma (HP:0002885)2.24534672
44Multiple enchondromatosis (HP:0005701)2.23663559
45Exercise-induced myalgia (HP:0003738)2.22197530
46Abnormality of the anterior horn cell (HP:0006802)2.21904643
47Degeneration of anterior horn cells (HP:0002398)2.21904643
48Centrally nucleated skeletal muscle fibers (HP:0003687)2.19209271
49Proximal placement of thumb (HP:0009623)2.18332687
50Facial hemangioma (HP:0000329)2.16491050
51Volvulus (HP:0002580)2.15625404
52Difficulty climbing stairs (HP:0003551)2.15035102
53Trismus (HP:0000211)2.13346188
54Abnormality of the salivary glands (HP:0010286)2.13106386
55Abnormality of the umbilical cord (HP:0010881)2.10852108
56Carpal bone hypoplasia (HP:0001498)2.02322931
57Patellar aplasia (HP:0006443)2.00394106
58Subaortic stenosis (HP:0001682)1.99935085
59Abnormality of the left ventricular outflow tract (HP:0011103)1.99935085
60Slender long bone (HP:0003100)1.99536843
61Asymmetry of the thorax (HP:0001555)1.99529566
62Spinal cord lesions (HP:0100561)1.99426030
63Syringomyelia (HP:0003396)1.99426030
64Short palpebral fissure (HP:0012745)1.99251150
65Rimmed vacuoles (HP:0003805)1.99005817
66High pitched voice (HP:0001620)1.98896034
67Absent phalangeal crease (HP:0006109)1.98339315
68Astrocytoma (HP:0009592)1.96031185
69Abnormality of the astrocytes (HP:0100707)1.96031185
70Aplasia/Hypoplasia of the patella (HP:0006498)1.95081905
71Achilles tendon contracture (HP:0001771)1.94838813
72Osteolytic defects of the hand bones (HP:0009699)1.94194500
73Osteolytic defects of the phalanges of the hand (HP:0009771)1.94194500
74Chromosomal breakage induced by crosslinking agents (HP:0003221)1.93320111
75Ragged-red muscle fibers (HP:0003200)1.92647142
76Small intestinal stenosis (HP:0012848)1.91674557
77Duodenal stenosis (HP:0100867)1.91674557
78Limb-girdle muscle weakness (HP:0003325)1.91587839
79Abnormality of oral frenula (HP:0000190)1.90613865
80Abnormality of glycolysis (HP:0004366)1.88690187
81Leiomyosarcoma (HP:0100243)1.87782077
82Uterine leiomyosarcoma (HP:0002891)1.87782077
83Increased nuchal translucency (HP:0010880)1.87458571
84Abnormality of the Achilles tendon (HP:0005109)1.84441997
85Rectal prolapse (HP:0002035)1.84430414
86Basal cell carcinoma (HP:0002671)1.84057845
87Abnormalities of placenta or umbilical cord (HP:0001194)1.83178634
88Abnormal lung lobation (HP:0002101)1.83070168
89Genu recurvatum (HP:0002816)1.82448488
90Metatarsus adductus (HP:0001840)1.81959890
91Increased serum pyruvate (HP:0003542)1.80737993
92Breech presentation (HP:0001623)1.79817984
93Myelodysplasia (HP:0002863)1.79207020
94Gastrointestinal carcinoma (HP:0002672)1.78723443
95Malignant gastrointestinal tract tumors (HP:0006749)1.78723443
96Premature rupture of membranes (HP:0001788)1.78568166
97Spastic diplegia (HP:0001264)1.78247394
98Distal lower limb amyotrophy (HP:0008944)1.78074092
99Meckel diverticulum (HP:0002245)1.77715359
100Neoplasm of the small intestine (HP:0100833)1.77538051
101Neoplasm of the pancreas (HP:0002894)1.76725976
102Adenoma sebaceum (HP:0009720)1.76432366
103Angiofibromas (HP:0010615)1.76432366
104Reticulocytopenia (HP:0001896)1.75066223
105Cafe-au-lait spot (HP:0000957)1.74978760
106Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.74936505
107Atresia of the external auditory canal (HP:0000413)1.74833625
108Wrist flexion contracture (HP:0001239)1.74310874
109Pili torti (HP:0003777)1.73127217
110Slender build (HP:0001533)1.72763022
111Neck muscle weakness (HP:0000467)1.72646320
112Progressive muscle weakness (HP:0003323)1.71435315
113Prominent nose (HP:0000448)1.71269279
114Spinal rigidity (HP:0003306)1.70664530
115Aplastic anemia (HP:0001915)1.70229589
116Metaphyseal cupping (HP:0003021)1.69044162
117Abnormality of the labia minora (HP:0012880)1.69018149
118Back pain (HP:0003418)1.69009132
119Blepharitis (HP:0000498)1.68223426
120Pterygium (HP:0001059)1.68120375
121Abnormal cartilage morphology (HP:0002763)1.67986846
122Neoplasm of the rectum (HP:0100743)1.66214621
123EMG: myopathic abnormalities (HP:0003458)1.66066034
124Neoplasm of striated muscle (HP:0009728)1.65968112
125Rough bone trabeculation (HP:0100670)1.65923393
126Abnormality of lateral ventricle (HP:0030047)1.65570367
127Abnormality of the preputium (HP:0100587)1.65325004
128Missing ribs (HP:0000921)1.65146522
129Right ventricular cardiomyopathy (HP:0011663)1.65049291
130Abnormality of methionine metabolism (HP:0010901)1.64607070
131Glioma (HP:0009733)1.64451867
132Abnormality of the ileum (HP:0001549)1.63709496
133Choanal atresia (HP:0000453)1.63644661
134Malignant hyperthermia (HP:0002047)1.63446905
135Uterine neoplasm (HP:0010784)1.62660715
136Abnormality of skeletal muscle fiber size (HP:0012084)1.62324939
137Short middle phalanx of the 5th finger (HP:0004220)1.60928463
138Single umbilical artery (HP:0001195)1.60886343
139Abnormality of the fetal cardiovascular system (HP:0010948)1.60886343
140Abnormal umbilical cord blood vessels (HP:0011403)1.60886343
141Neoplasm of the colon (HP:0100273)1.60490328
142Cortical dysplasia (HP:0002539)1.59919228
143Acute myeloid leukemia (HP:0004808)1.58519161
144Limb-girdle muscle atrophy (HP:0003797)1.57705147
145Glossoptosis (HP:0000162)1.56584604
146Sparse lateral eyebrow (HP:0005338)1.56453656
147Areflexia of lower limbs (HP:0002522)1.56345780
148Aplasia/Hypoplasia of the uvula (HP:0010293)1.55232862

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.97992544
2PBK3.79042523
3WEE13.34852881
4NEK12.99065180
5EIF2AK12.72585232
6PKN22.60031181
7NEK22.53923164
8EEF2K2.49220635
9LATS12.36297964
10TRIB32.33227830
11BUB12.26653616
12TTK2.19306118
13RPS6KA42.18814919
14SCYL22.01649287
15CDK122.00317185
16MST1R1.93488040
17MST41.89006562
18BRSK21.81850280
19TTN1.74512466
20ACVR1B1.70007196
21SMG11.67506199
22RPS6KB21.67398999
23STK31.66608323
24STK101.62240264
25CDK41.61730500
26CDK61.60371400
27SRPK11.59768094
28IRAK31.59472379
29LATS21.58592231
30MAP3K81.57851462
31NME21.53083723
32PLK41.51989352
33PLK11.49652719
34AURKB1.46905623
35TAF11.41339946
36MAP3K101.36343806
37CDK71.33771559
38MKNK11.28131740
39TESK21.26678899
40TSSK61.26100803
41EIF2AK31.23249552
42MAP2K31.21252598
43DYRK31.20679431
44MET1.18532277
45NEK91.18031700
46STK38L1.17893130
47PLK31.17852084
48ATR1.17608845
49EPHA21.15914820
50PAK41.13818532
51CHEK21.09172705
52FLT31.07994922
53LRRK21.06411693
54CHEK11.05943368
55BRD41.05080191
56PASK1.05009616
57ALK1.02323283
58TRIM280.96851242
59EIF2AK20.92320511
60MKNK20.90643333
61MAPKAPK30.86366907
62BRAF0.82392903
63OBSCN0.81581879
64MAP3K30.81441494
65ATM0.81092427
66TGFBR10.79816332
67PNCK0.78342298
68BRSK10.78309465
69PIM10.76764335
70MELK0.76168399
71ERBB40.75264660
72AURKA0.74200145
73CDK20.73464931
74TAOK10.72797677
75MTOR0.72256387
76MAP3K110.70874039
77MAP3K50.69940071
78PDK20.69686721
79PRPF4B0.68349775
80CLK10.66560945
81TESK10.66219545
82ICK0.65622072
83MAP3K90.64938596
84PAK20.64563473
85KSR20.64329704
86STK40.62516478
87CDK80.60864200
88RAF10.59483371
89PTK60.58085567
90ZAK0.57958697
91TAOK20.57650964
92PDK30.56111546
93PDK40.56111546
94VRK20.54410497
95MAP3K60.53848679
96MOS0.53330755
97MAPK110.52582321
98STK240.51380721
99MAP3K140.50881943
100CDK10.49617029
101PIM20.49434097
102DMPK0.49284218
103FGFR10.49031921
104PDGFRA0.48892642
105AKT20.47117796
106PTK20.46940889
107LIMK10.46787889
108TRPM70.46199809
109PIK3CG0.46039376
110CSNK2A20.45701317
111BCKDK0.45015774
112BCR0.44349850
113KSR10.40274238
114STK160.40181951
115ABL20.39964034
116BMX0.39806460
117PAK10.39357007
118SIK30.39014587
119CSNK2A10.38786085
120YES10.38182569
121DDR20.35740095
122RPS6KB10.35591076
123ERBB30.34514320
124JAK30.34286921
125CCNB10.34272865
126CSNK1E0.33743480
127CDK90.31040274
128PRKDC0.30539996

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.30440287
2Mismatch repair_Homo sapiens_hsa034303.38998208
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.26030037
4RNA transport_Homo sapiens_hsa030133.11063102
5One carbon pool by folate_Homo sapiens_hsa006703.01086597
6Cell cycle_Homo sapiens_hsa041102.97129476
7Spliceosome_Homo sapiens_hsa030402.58056161
8Nucleotide excision repair_Homo sapiens_hsa034202.29114534
9Base excision repair_Homo sapiens_hsa034102.29112658
10Homologous recombination_Homo sapiens_hsa034402.13773000
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.11909523
12p53 signaling pathway_Homo sapiens_hsa041151.90754330
13RNA degradation_Homo sapiens_hsa030181.72197040
14mRNA surveillance pathway_Homo sapiens_hsa030151.59224036
15Pyrimidine metabolism_Homo sapiens_hsa002401.55326132
16Fanconi anemia pathway_Homo sapiens_hsa034601.54690648
17Proteasome_Homo sapiens_hsa030501.52369317
18RNA polymerase_Homo sapiens_hsa030201.47273499
19Ribosome_Homo sapiens_hsa030101.46876433
20Biosynthesis of amino acids_Homo sapiens_hsa012301.46413348
21Selenocompound metabolism_Homo sapiens_hsa004501.32738138
22Pyruvate metabolism_Homo sapiens_hsa006201.25818196
23Pentose phosphate pathway_Homo sapiens_hsa000301.23895166
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.18897902
25Non-homologous end-joining_Homo sapiens_hsa034501.17646656
26MicroRNAs in cancer_Homo sapiens_hsa052061.15623989
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.15307568
28Thyroid cancer_Homo sapiens_hsa052161.14073770
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13689798
30Small cell lung cancer_Homo sapiens_hsa052221.11909282
31Viral carcinogenesis_Homo sapiens_hsa052031.11224059
32Carbon metabolism_Homo sapiens_hsa012001.10978740
33Basal transcription factors_Homo sapiens_hsa030221.10689265
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.10268533
35Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.10219349
36Antigen processing and presentation_Homo sapiens_hsa046121.00984137
37Epstein-Barr virus infection_Homo sapiens_hsa051690.98134986
38Chronic myeloid leukemia_Homo sapiens_hsa052200.97734241
39Folate biosynthesis_Homo sapiens_hsa007900.97171993
40Cyanoamino acid metabolism_Homo sapiens_hsa004600.96477814
41Oocyte meiosis_Homo sapiens_hsa041140.95563449
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94454895
43HTLV-I infection_Homo sapiens_hsa051660.92797730
44Bladder cancer_Homo sapiens_hsa052190.91717147
45Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89816339
46Legionellosis_Homo sapiens_hsa051340.89050359
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88311329
48Herpes simplex infection_Homo sapiens_hsa051680.87435579
49Drug metabolism - other enzymes_Homo sapiens_hsa009830.87121921
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85589111
51mTOR signaling pathway_Homo sapiens_hsa041500.85169424
52TGF-beta signaling pathway_Homo sapiens_hsa043500.83439799
53Central carbon metabolism in cancer_Homo sapiens_hsa052300.81002619
54Nitrogen metabolism_Homo sapiens_hsa009100.78710369
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77325675
56Adherens junction_Homo sapiens_hsa045200.76757040
57Sulfur relay system_Homo sapiens_hsa041220.76595513
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75473603
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74983022
60Lysine degradation_Homo sapiens_hsa003100.70235389
61Vitamin B6 metabolism_Homo sapiens_hsa007500.69711522
62Systemic lupus erythematosus_Homo sapiens_hsa053220.69551171
63Hepatitis B_Homo sapiens_hsa051610.68860275
64Fatty acid elongation_Homo sapiens_hsa000620.68772901
65Protein export_Homo sapiens_hsa030600.68650563
66Colorectal cancer_Homo sapiens_hsa052100.67408094
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66462824
68Pancreatic cancer_Homo sapiens_hsa052120.65264353
69N-Glycan biosynthesis_Homo sapiens_hsa005100.65263922
70Proteoglycans in cancer_Homo sapiens_hsa052050.64072148
71Hippo signaling pathway_Homo sapiens_hsa043900.63592268
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63278584
73Viral myocarditis_Homo sapiens_hsa054160.63191447
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63179888
75Apoptosis_Homo sapiens_hsa042100.61063863
76Steroid biosynthesis_Homo sapiens_hsa001000.60807865
77HIF-1 signaling pathway_Homo sapiens_hsa040660.59994949
78Propanoate metabolism_Homo sapiens_hsa006400.59735376
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59334955
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57374921
81Fructose and mannose metabolism_Homo sapiens_hsa000510.57234259
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56510924
83Shigellosis_Homo sapiens_hsa051310.55912981
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55519480
85Purine metabolism_Homo sapiens_hsa002300.55386630
86Acute myeloid leukemia_Homo sapiens_hsa052210.51745490
87Non-small cell lung cancer_Homo sapiens_hsa052230.51402039
88AMPK signaling pathway_Homo sapiens_hsa041520.48693307
89Tight junction_Homo sapiens_hsa045300.47502126
90Prostate cancer_Homo sapiens_hsa052150.47489211
91FoxO signaling pathway_Homo sapiens_hsa040680.47369408
92Arginine biosynthesis_Homo sapiens_hsa002200.47253769
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47041978
94Glutathione metabolism_Homo sapiens_hsa004800.43400750
95Arginine and proline metabolism_Homo sapiens_hsa003300.43188972
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42969294
97Caffeine metabolism_Homo sapiens_hsa002320.42884702
98Focal adhesion_Homo sapiens_hsa045100.42770251
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39949077
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39455931
101Insulin signaling pathway_Homo sapiens_hsa049100.36613221
102Endometrial cancer_Homo sapiens_hsa052130.36122029
103Wnt signaling pathway_Homo sapiens_hsa043100.36022473
104Galactose metabolism_Homo sapiens_hsa000520.33895870
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33339421
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.33092708
107Glioma_Homo sapiens_hsa052140.31943028
108Insulin resistance_Homo sapiens_hsa049310.31792431
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31504061
110Starch and sucrose metabolism_Homo sapiens_hsa005000.30717664
111Renal cell carcinoma_Homo sapiens_hsa052110.29726811
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29450959
113Glucagon signaling pathway_Homo sapiens_hsa049220.28958829
114Fatty acid degradation_Homo sapiens_hsa000710.27630720
115Pathways in cancer_Homo sapiens_hsa052000.27405297
116Fatty acid metabolism_Homo sapiens_hsa012120.27185130
117AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.26969437
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26946083
119Melanoma_Homo sapiens_hsa052180.26811560
120Measles_Homo sapiens_hsa051620.26622423
121Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26387345

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