NAA40

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.40902499
2DNA strand elongation involved in DNA replication (GO:0006271)4.95154474
3protein localization to kinetochore (GO:0034501)4.84061612
4DNA strand elongation (GO:0022616)4.72107630
5DNA replication initiation (GO:0006270)4.68313301
6telomere maintenance via semi-conservative replication (GO:0032201)4.51121479
7protein localization to chromosome, centromeric region (GO:0071459)4.24423650
8DNA replication-dependent nucleosome assembly (GO:0006335)4.12423947
9DNA replication-dependent nucleosome organization (GO:0034723)4.12423947
10mitotic nuclear envelope disassembly (GO:0007077)4.12364428
11mitotic chromosome condensation (GO:0007076)4.11919890
12telomere maintenance via recombination (GO:0000722)4.01346799
13DNA replication checkpoint (GO:0000076)3.98476653
14mitotic sister chromatid segregation (GO:0000070)3.90923610
15mitotic recombination (GO:0006312)3.90073726
16nuclear envelope disassembly (GO:0051081)3.85229279
17membrane disassembly (GO:0030397)3.85229279
18folic acid-containing compound biosynthetic process (GO:0009396)3.73068235
19nuclear pore organization (GO:0006999)3.72111472
20DNA duplex unwinding (GO:0032508)3.70959025
21sister chromatid segregation (GO:0000819)3.70497971
22formation of translation preinitiation complex (GO:0001731)3.69546203
23DNA geometric change (GO:0032392)3.69493395
24IMP biosynthetic process (GO:0006188)3.65891149
25nucleobase biosynthetic process (GO:0046112)3.64568149
26nuclear pore complex assembly (GO:0051292)3.62597118
27nucleosome disassembly (GO:0006337)3.61260874
28protein-DNA complex disassembly (GO:0032986)3.61260874
29mitotic metaphase plate congression (GO:0007080)3.60280101
30telomere maintenance via telomere lengthening (GO:0010833)3.58861284
31regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.55185328
32negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.51733379
33regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.51152694
34nucleotide-excision repair, DNA gap filling (GO:0006297)3.49895310
35negative regulation of histone methylation (GO:0031061)3.49608719
36dosage compensation (GO:0007549)3.47445048
37translesion synthesis (GO:0019985)3.46724583
38regulation of histone H3-K9 methylation (GO:0051570)3.44216881
39DNA replication-independent nucleosome assembly (GO:0006336)3.40140036
40DNA replication-independent nucleosome organization (GO:0034724)3.40140036
41negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.34587297
42negative regulation of translation, ncRNA-mediated (GO:0040033)3.34587297
43regulation of translation, ncRNA-mediated (GO:0045974)3.34587297
44IMP metabolic process (GO:0046040)3.32595995
45protein localization to chromosome (GO:0034502)3.31587308
46attachment of spindle microtubules to kinetochore (GO:0008608)3.29156636
47pyrimidine nucleobase catabolic process (GO:0006208)3.27055469
48negative regulation of RNA splicing (GO:0033119)3.25353744
49chromatin remodeling at centromere (GO:0031055)3.24087161
50CENP-A containing nucleosome assembly (GO:0034080)3.23615219
51somatic diversification of immune receptors via somatic mutation (GO:0002566)3.22623089
52somatic hypermutation of immunoglobulin genes (GO:0016446)3.22623089
53DNA topological change (GO:0006265)3.22514608
54purine nucleobase biosynthetic process (GO:0009113)3.21149996
55mitotic sister chromatid cohesion (GO:0007064)3.19978035
56chromatin assembly or disassembly (GO:0006333)3.19750124
57kinetochore organization (GO:0051383)3.18769930
58metaphase plate congression (GO:0051310)3.18729913
59postsynaptic membrane organization (GO:0001941)3.18545881
60regulation of spindle organization (GO:0090224)3.16410940
61DNA conformation change (GO:0071103)3.16334321
62DNA deamination (GO:0045006)3.14566186
63presynaptic membrane assembly (GO:0097105)3.11601783
64ribosomal small subunit assembly (GO:0000028)3.09006636
65maturation of SSU-rRNA (GO:0030490)3.08806190
66postreplication repair (GO:0006301)3.08564402
67intra-S DNA damage checkpoint (GO:0031573)3.07786464
68meiotic chromosome segregation (GO:0045132)3.07763546
69nuclear envelope organization (GO:0006998)3.07010250
70pre-miRNA processing (GO:0031054)3.05983019
71behavioral response to nicotine (GO:0035095)3.02494623
72regulation of sister chromatid cohesion (GO:0007063)3.01339002
73base-excision repair (GO:0006284)3.01331731
74histone H3-K9 methylation (GO:0051567)3.01249329
75protein polyglutamylation (GO:0018095)3.00261881
76heterochromatin organization (GO:0070828)2.98235713
77regulation of chromosome segregation (GO:0051983)2.97966039
78histone H2A acetylation (GO:0043968)2.97934048
79peptidyl-arginine methylation (GO:0018216)2.97804736
80peptidyl-arginine N-methylation (GO:0035246)2.97804736
81establishment of chromosome localization (GO:0051303)2.97540692
82regulation of double-strand break repair via homologous recombination (GO:0010569)2.97302315
83negative regulation of mRNA processing (GO:0050686)2.95306855
84chromosome condensation (GO:0030261)2.91758513
85maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.91664433
86ribosome biogenesis (GO:0042254)2.91480291
87chromosome segregation (GO:0007059)2.90478379
88negative regulation of chromosome segregation (GO:0051985)2.90414245
89histone exchange (GO:0043486)2.89551627
90positive regulation of chromosome segregation (GO:0051984)2.88662741
91ATP-dependent chromatin remodeling (GO:0043044)2.88643999
92negative regulation of mRNA metabolic process (GO:1903312)2.88184138
93RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.86804173
94mRNA splicing, via spliceosome (GO:0000398)2.86804173
95presynaptic membrane organization (GO:0097090)2.85303872
96RNA splicing, via transesterification reactions (GO:0000375)2.85024945
97mismatch repair (GO:0006298)2.83777930
98telomere maintenance (GO:0000723)2.81992862
99regulation of nuclear cell cycle DNA replication (GO:0033262)2.81748484
100kinetochore assembly (GO:0051382)2.81128440
101negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.81001311
102negative regulation of sister chromatid segregation (GO:0033046)2.81001311
103negative regulation of mitotic sister chromatid separation (GO:2000816)2.81001311
104negative regulation of mitotic sister chromatid segregation (GO:0033048)2.81001311
105termination of RNA polymerase II transcription (GO:0006369)2.80989482
106telomere organization (GO:0032200)2.79877399
107spindle assembly checkpoint (GO:0071173)2.79178858
108spliceosomal snRNP assembly (GO:0000387)2.79100549
109negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.77986442
110chromatin assembly (GO:0031497)2.76239199
111mitotic spindle assembly checkpoint (GO:0007094)2.75222336
112peptidyl-arginine omega-N-methylation (GO:0035247)2.74441698
113cell migration in hindbrain (GO:0021535)2.72921441
114regulation of centrosome cycle (GO:0046605)2.72472954
115mRNA transport (GO:0051028)2.72430180
116mitotic G1 DNA damage checkpoint (GO:0031571)2.72172232
117positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.72049018
118DNA synthesis involved in DNA repair (GO:0000731)2.71458713
119spindle checkpoint (GO:0031577)2.70807927
120regulation of translational fidelity (GO:0006450)2.70136660
121mRNA splice site selection (GO:0006376)2.67787381
122hindbrain development (GO:0030902)2.66911357
123establishment of mitochondrion localization (GO:0051654)2.64899216
124olfactory bulb development (GO:0021772)2.64786715
125negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.64718932
126nonmotile primary cilium assembly (GO:0035058)2.64471145
127DNA alkylation (GO:0006305)2.63948245
128DNA methylation (GO:0006306)2.63948245
129regulation of mRNA splicing, via spliceosome (GO:0048024)2.62760169
130intraciliary transport (GO:0042073)2.60822099
131histone arginine methylation (GO:0034969)2.60398984
132negative regulation of DNA-templated transcription, elongation (GO:0032785)2.60327168
133DNA damage response, detection of DNA damage (GO:0042769)2.60139294
134spinal cord development (GO:0021510)2.58904963
135response to pheromone (GO:0019236)2.58406971
136axonemal dynein complex assembly (GO:0070286)2.57955910
137mRNA polyadenylation (GO:0006378)2.56895308
138spliceosomal tri-snRNP complex assembly (GO:0000244)2.56126099
139DNA double-strand break processing (GO:0000729)2.54981448
140nucleobase catabolic process (GO:0046113)2.53753026
141head development (GO:0060322)2.53261053
142RNA localization (GO:0006403)2.51875233
143epithelial cilium movement (GO:0003351)2.51735300
144establishment of integrated proviral latency (GO:0075713)2.50655648
145calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.50082483
146non-recombinational repair (GO:0000726)2.49541124
147double-strand break repair via nonhomologous end joining (GO:0006303)2.49541124
148regulation of centrosome duplication (GO:0010824)2.49340499
149neuron cell-cell adhesion (GO:0007158)2.47588553
150regulation of gene silencing by RNA (GO:0060966)2.47476947
151regulation of posttranscriptional gene silencing (GO:0060147)2.47476947
152regulation of gene silencing by miRNA (GO:0060964)2.47476947
153regulation of histone H3-K4 methylation (GO:0051569)2.47117571
154regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.45771380
155regulation of development, heterochronic (GO:0040034)2.44436549
156DNA ligation (GO:0006266)2.44187738
157stress granule assembly (GO:0034063)2.43906392
158RNA polyadenylation (GO:0043631)2.42165549
159retinal ganglion cell axon guidance (GO:0031290)2.42066446
160regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.41309453
161DNA damage induced protein phosphorylation (GO:0006975)2.40193559
162axonal fasciculation (GO:0007413)2.39660929
163DNA strand renaturation (GO:0000733)2.35883877
164RNA export from nucleus (GO:0006405)2.34913646
165histone H3-K9 modification (GO:0061647)2.33999577
166regulation of chromatin binding (GO:0035561)2.33631057
167mitochondrion transport along microtubule (GO:0047497)2.31355642
168establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.31355642
169positive regulation of cell cycle checkpoint (GO:1901978)2.30920101
170negative regulation of gene expression, epigenetic (GO:0045814)2.30813140

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.35438642
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.74676487
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.61155589
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.53975673
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.48766664
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.15065518
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.83263642
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.69228338
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.64263831
10* MYC_22102868_ChIP-Seq_BL_Human2.62197371
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.55664100
12ZNF274_21170338_ChIP-Seq_K562_Hela2.49377781
13EZH2_22144423_ChIP-Seq_EOC_Human2.45411555
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.39697059
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.38405425
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.36593108
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.33956274
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.24433953
19E2F1_21310950_ChIP-Seq_MCF-7_Human2.12232645
20XRN2_22483619_ChIP-Seq_HELA_Human2.08032762
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.04285450
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.04054634
23IGF1R_20145208_ChIP-Seq_DFB_Human2.03579046
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.03141545
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.01937961
26CIITA_25753668_ChIP-Seq_RAJI_Human2.01788793
27CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.00453744
28AR_21909140_ChIP-Seq_LNCAP_Human1.97195889
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.90335163
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.88221418
31VDR_21846776_ChIP-Seq_THP-1_Human1.87652374
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.79209247
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.76217968
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.76029103
35MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74498335
36VDR_23849224_ChIP-Seq_CD4+_Human1.73370747
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.68736316
38GABP_19822575_ChIP-Seq_HepG2_Human1.66955472
39KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.66617089
40FOXP3_21729870_ChIP-Seq_TREG_Human1.65137123
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.64211268
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.57282255
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.56993214
44* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.56674264
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56252547
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55918066
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.55191753
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.55159036
49SOX2_16153702_ChIP-ChIP_HESCs_Human1.53855581
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53513903
51KDM5A_27292631_Chip-Seq_BREAST_Human1.52339283
52DCP1A_22483619_ChIP-Seq_HELA_Human1.50835199
53CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.50696018
54TTF2_22483619_ChIP-Seq_HELA_Human1.50131829
55MYC_18940864_ChIP-ChIP_HL60_Human1.48348002
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.47736175
57THAP11_20581084_ChIP-Seq_MESCs_Mouse1.47254607
58TP63_19390658_ChIP-ChIP_HaCaT_Human1.43304843
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37263802
60POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36935464
61IRF1_19129219_ChIP-ChIP_H3396_Human1.35628278
62SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.35416872
63DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.33801360
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32968288
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31775734
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29785373
67PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.29440251
68* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.29298935
69SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.27444871
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26803874
71YY1_21170310_ChIP-Seq_MESCs_Mouse1.26136652
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25279955
73NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.23482372
74E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.22256173
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22177110
76* TFEB_21752829_ChIP-Seq_HELA_Human1.22172941
77POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21125672
78FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18930409
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18251748
80ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17820976
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14980940
82STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14823281
83E2F1_17053090_ChIP-ChIP_MCF-7_Human1.14730159
84REST_18959480_ChIP-ChIP_MESCs_Mouse1.13148429
85CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.12972150
86TCF7_22412390_ChIP-Seq_EML_Mouse1.11804547
87CBX2_27304074_Chip-Seq_ESCs_Mouse1.11519218
88CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.10969063
89UTX_26944678_Chip-Seq_JUKART_Human1.09506036
90CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08961360
91NANOG_21062744_ChIP-ChIP_HESCs_Human1.08423525
92NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.07824817
93SPI1_23547873_ChIP-Seq_NB4_Human1.06823628
94MAF_26560356_Chip-Seq_TH1_Human1.06427448
95SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01923524
96* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.01826937
97FUS_26573619_Chip-Seq_HEK293_Human1.01775743
98GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01279320
99SCL_19346495_ChIP-Seq_HPC-7_Human1.00578634
100ELK1_19687146_ChIP-ChIP_HELA_Human1.00427620
101RNF2_27304074_Chip-Seq_NSC_Mouse0.99286673
102DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99245004
103KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98086779
104MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.97827713
105HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.97395672
106CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94359182
107CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94344740
108CTBP2_25329375_ChIP-Seq_LNCAP_Human0.93047749
109* FOXP1_21924763_ChIP-Seq_HESCs_Human0.92989666
110POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92657635
111EWS_26573619_Chip-Seq_HEK293_Human0.92220374
112KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.91737401
113MYB_26560356_Chip-Seq_TH2_Human0.91398999
114SOX9_26525672_Chip-Seq_HEART_Mouse0.91148213
115EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90549345
116POU5F1_16518401_ChIP-PET_MESCs_Mouse0.90259026
117REST_21632747_ChIP-Seq_MESCs_Mouse0.90045428
118TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89021939
119POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89021939
120TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.88950453
121* MYB_26560356_Chip-Seq_TH1_Human0.88949933
122ZFP281_18757296_ChIP-ChIP_E14_Mouse0.87846429
123BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87722437
124NANOG_16153702_ChIP-ChIP_HESCs_Human0.87598860
125NOTCH1_21737748_ChIP-Seq_TLL_Human0.87557044
126WDR5_24793694_ChIP-Seq_LNCAP_Human0.87411668
127ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.87176510
128RUNX1_22412390_ChIP-Seq_EML_Mouse0.86821912
129SRF_21415370_ChIP-Seq_HL-1_Mouse0.86695782
130MYB_21317192_ChIP-Seq_ERMYB_Mouse0.86534714
131* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85989491
132ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85823831
133OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.85747337
134PKCTHETA_26484144_Chip-Seq_BREAST_Human0.85076862
135KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.84668842
136RBPJ_22232070_ChIP-Seq_NCS_Mouse0.83961703
137MAF_26560356_Chip-Seq_TH2_Human0.83806562
138KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.82933389
139E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.82068728
140GATA1_22383799_ChIP-Seq_G1ME_Mouse0.81963978
141VDR_24763502_ChIP-Seq_THP-1_Human0.81190427

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.49926560
2MP0010094_abnormal_chromosome_stability4.45706834
3MP0003111_abnormal_nucleus_morphology4.31811584
4MP0008057_abnormal_DNA_replication4.12864756
5MP0003077_abnormal_cell_cycle3.81178989
6MP0004957_abnormal_blastocyst_morpholog3.76463623
7MP0002396_abnormal_hematopoietic_system2.97267330
8MP0008058_abnormal_DNA_repair2.89897101
9MP0008007_abnormal_cellular_replicative2.50875897
10MP0003787_abnormal_imprinting2.50664596
11MP0010352_gastrointestinal_tract_polyps2.42996964
12MP0008877_abnormal_DNA_methylation2.38325280
13MP0003122_maternal_imprinting2.37121542
14MP0001529_abnormal_vocalization2.36283779
15MP0000778_abnormal_nervous_system2.35361503
16MP0001730_embryonic_growth_arrest2.32964684
17MP0000350_abnormal_cell_proliferation2.29819550
18MP0008932_abnormal_embryonic_tissue2.14481171
19MP0003880_abnormal_central_pattern2.13207615
20MP0000490_abnormal_crypts_of2.11908535
21MP0004808_abnormal_hematopoietic_stem2.10619757
22MP0002822_catalepsy2.08828634
23MP0010307_abnormal_tumor_latency2.05506772
24MP0003123_paternal_imprinting2.01373865
25MP0006276_abnormal_autonomic_nervous1.82286899
26MP0001672_abnormal_embryogenesis/_devel1.80310758
27MP0005380_embryogenesis_phenotype1.80310758
28MP0005397_hematopoietic_system_phenotyp1.78683500
29MP0001545_abnormal_hematopoietic_system1.78683500
30MP0001697_abnormal_embryo_size1.78253306
31MP0006072_abnormal_retinal_apoptosis1.73333609
32MP0002102_abnormal_ear_morphology1.68370310
33MP0003763_abnormal_thymus_physiology1.66425513
34MP0003984_embryonic_growth_retardation1.66194872
35MP0005394_taste/olfaction_phenotype1.64858008
36MP0005499_abnormal_olfactory_system1.64858008
37MP0002080_prenatal_lethality1.62910681
38MP0002088_abnormal_embryonic_growth/wei1.62775974
39MP0005076_abnormal_cell_differentiation1.62097844
40MP0002085_abnormal_embryonic_tissue1.61369853
41MP0009278_abnormal_bone_marrow1.60598113
42MP0003861_abnormal_nervous_system1.59788352
43MP0002084_abnormal_developmental_patter1.59667360
44MP0002019_abnormal_tumor_incidence1.59642645
45MP0008789_abnormal_olfactory_epithelium1.55798765
46MP0003121_genomic_imprinting1.54667821
47MP0000313_abnormal_cell_death1.53863018
48MP0003786_premature_aging1.51993678
49MP0002086_abnormal_extraembryonic_tissu1.51959655
50MP0002398_abnormal_bone_marrow1.51477560
51MP0002751_abnormal_autonomic_nervous1.51343090
52MP0002653_abnormal_ependyma_morphology1.50956291
53MP0000566_synostosis1.47978653
54MP0000703_abnormal_thymus_morphology1.46408444
55MP0002697_abnormal_eye_size1.44111603
56MP0004197_abnormal_fetal_growth/weight/1.41884467
57MP0000631_abnormal_neuroendocrine_gland1.40787899
58MP0002938_white_spotting1.40161239
59MP0003937_abnormal_limbs/digits/tail_de1.39000001
60MP0003890_abnormal_embryonic-extraembry1.34042074
61MP0002722_abnormal_immune_system1.33889800
62MP0009333_abnormal_splenocyte_physiolog1.32932018
63MP0000689_abnormal_spleen_morphology1.31470278
64MP0001346_abnormal_lacrimal_gland1.29199374
65MP0003567_abnormal_fetal_cardiomyocyte1.28616489
66MP0002909_abnormal_adrenal_gland1.28277150
67MP0001286_abnormal_eye_development1.27692792
68MP0001293_anophthalmia1.27018823
69MP0002210_abnormal_sex_determination1.26788645
70MP0002233_abnormal_nose_morphology1.23127858
71MP0002184_abnormal_innervation1.22612770
72MP0005645_abnormal_hypothalamus_physiol1.20909289
73MP0000049_abnormal_middle_ear1.19450099
74MP0002163_abnormal_gland_morphology1.18107511
75MP0002928_abnormal_bile_duct1.16738980
76MP0001929_abnormal_gametogenesis1.13323868
77MP0003938_abnormal_ear_development1.12971919
78MP0002429_abnormal_blood_cell1.12551882
79MP0003283_abnormal_digestive_organ1.10218414
80MP0001145_abnormal_male_reproductive1.10059888
81MP0003878_abnormal_ear_physiology1.08214126
82MP0005377_hearing/vestibular/ear_phenot1.08214126
83MP0002152_abnormal_brain_morphology1.06475884
84MP0000955_abnormal_spinal_cord1.06322940
85MP0001984_abnormal_olfaction1.04333208
86MP0004859_abnormal_synaptic_plasticity1.03936445
87MP0002557_abnormal_social/conspecific_i1.03516227
88MP0003221_abnormal_cardiomyocyte_apopto1.03018086
89MP0000716_abnormal_immune_system1.01130000
90MP0003942_abnormal_urinary_system1.00963815
91MP0001986_abnormal_taste_sensitivity1.00735921
92MP0005220_abnormal_exocrine_pancreas1.00134862
93MP0001800_abnormal_humoral_immune1.00029371
94MP0001968_abnormal_touch/_nociception0.99252799
95MP0001849_ear_inflammation0.99039014
96MP0003943_abnormal_hepatobiliary_system0.98254144
97MP0003705_abnormal_hypodermis_morpholog0.96462856
98MP0006054_spinal_hemorrhage0.96197748
99MP0003755_abnormal_palate_morphology0.94518377
100MP0005391_vision/eye_phenotype0.94227759
101MP0000685_abnormal_immune_system0.94125809
102MP0001299_abnormal_eye_distance/0.94010174
103MP0004145_abnormal_muscle_electrophysio0.93252002
104MP0000427_abnormal_hair_cycle0.93109231
105MP0004811_abnormal_neuron_physiology0.92762644
106MP0002752_abnormal_somatic_nervous0.91481112
107MP0000653_abnormal_sex_gland0.91329921
108MP0005253_abnormal_eye_physiology0.90579637
109MP0003119_abnormal_digestive_system0.90534595
110MP0002116_abnormal_craniofacial_bone0.89676317
111MP0002405_respiratory_system_inflammati0.89230520
112MP0002009_preneoplasia0.89168570
113MP0005384_cellular_phenotype0.88575505
114MP0004043_abnormal_pH_regulation0.88552742
115MP0001915_intracranial_hemorrhage0.88448831
116MP0002081_perinatal_lethality0.87637061
117MP0001835_abnormal_antigen_presentation0.86853525
118MP0002882_abnormal_neuron_morphology0.86361716
119MP0005621_abnormal_cell_physiology0.86115844
120MP0003115_abnormal_respiratory_system0.86106642
121MP0002420_abnormal_adaptive_immunity0.85503494
122MP0010030_abnormal_orbit_morphology0.85344337
123MP0006292_abnormal_olfactory_placode0.84117353
124MP0001819_abnormal_immune_cell0.83951766
125MP0002452_abnormal_antigen_presenting0.83707667
126MP0000358_abnormal_cell_content/0.83250417
127MP0000858_altered_metastatic_potential0.80712058
128MP0002092_abnormal_eye_morphology0.80698585
129MP0009672_abnormal_birth_weight0.80418119
130MP0003935_abnormal_craniofacial_develop0.80347457
131MP0004233_abnormal_muscle_weight0.79745103
132MP0002735_abnormal_chemical_nociception0.79732544
133MP0000477_abnormal_intestine_morphology0.79561216
134MP0003315_abnormal_perineum_morphology0.78925764
135MP0001119_abnormal_female_reproductive0.78711476
136MP0001270_distended_abdomen0.78269021
137MP0004133_heterotaxia0.77455168
138MP0004264_abnormal_extraembryonic_tissu0.77405253
139MP0008770_decreased_survivor_rate0.76801535
140MP0005423_abnormal_somatic_nervous0.76433816
141MP0008961_abnormal_basal_metabolism0.75953722
142MP0000537_abnormal_urethra_morphology0.74418151
143MP0008995_early_reproductive_senescence0.74051373
144MP0000428_abnormal_craniofacial_morphol0.72615882
145MP0000465_gastrointestinal_hemorrhage0.71948013
146MP0005671_abnormal_response_to0.71095022
147MP0003566_abnormal_cell_adhesion0.69513825
148MP0002723_abnormal_immune_serum0.69470510
149MP0005023_abnormal_wound_healing0.69007017
150MP0009053_abnormal_anal_canal0.68405765
151MP0000733_abnormal_muscle_development0.67426095
152MP0009703_decreased_birth_body0.67121667
153MP0002925_abnormal_cardiovascular_devel0.67118888
154MP0003436_decreased_susceptibility_to0.64555485
155MP0010155_abnormal_intestine_physiology0.64526745
156MP0002111_abnormal_tail_morphology0.60810065
157MP0003303_peritoneal_inflammation0.60605336
158MP0000266_abnormal_heart_morphology0.59753748
159MP0003172_abnormal_lysosome_physiology0.59041143
160MP0003448_altered_tumor_morphology0.56682914
161MP0001873_stomach_inflammation0.56657160
162MP0002161_abnormal_fertility/fecundity0.56412221

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.14884629
2Birth length less than 3rd percentile (HP:0003561)3.83535508
3Chromsome breakage (HP:0040012)3.80263382
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.67477345
5High anterior hairline (HP:0009890)3.65988467
6Reticulocytopenia (HP:0001896)3.40277580
7Abnormality of the anterior horn cell (HP:0006802)3.33908323
8Degeneration of anterior horn cells (HP:0002398)3.33908323
9Medulloblastoma (HP:0002885)3.31838810
10Colon cancer (HP:0003003)3.22748858
11Selective tooth agenesis (HP:0001592)3.10108897
12Patellar aplasia (HP:0006443)3.08216781
13Abnormality of chromosome stability (HP:0003220)3.06856354
14Cortical dysplasia (HP:0002539)3.05937218
15Aplasia/Hypoplasia of the uvula (HP:0010293)3.03637175
16Myelodysplasia (HP:0002863)2.87967987
17Meckel diverticulum (HP:0002245)2.87487861
18Agnosia (HP:0010524)2.85267957
19Increased nuchal translucency (HP:0010880)2.84567695
20Abnormality of the ileum (HP:0001549)2.84177716
21Aplasia/Hypoplasia of the patella (HP:0006498)2.83257669
22Basal cell carcinoma (HP:0002671)2.79462592
23Abnormality of the astrocytes (HP:0100707)2.77651754
24Astrocytoma (HP:0009592)2.77651754
25Aplastic anemia (HP:0001915)2.76238278
26Impulsivity (HP:0100710)2.69794417
27Oral leukoplakia (HP:0002745)2.69574827
28Trigonocephaly (HP:0000243)2.68935690
29Abnormal number of erythroid precursors (HP:0012131)2.60384400
30Abnormality of abdominal situs (HP:0011620)2.60242314
31Abdominal situs inversus (HP:0003363)2.60242314
32Abnormality of cells of the erythroid lineage (HP:0012130)2.59070811
33Hypoplasia of the capital femoral epiphysis (HP:0003090)2.59034733
34Abnormality of the preputium (HP:0100587)2.57606447
35Bilateral microphthalmos (HP:0007633)2.55891603
36Nephronophthisis (HP:0000090)2.50908707
37Absent epiphyses (HP:0010577)2.49784246
38Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.49784246
39Small intestinal stenosis (HP:0012848)2.49681754
40Duodenal stenosis (HP:0100867)2.49681754
41Abnormal number of incisors (HP:0011064)2.49008497
42Ectopic kidney (HP:0000086)2.48484024
43Carpal bone hypoplasia (HP:0001498)2.46566139
44Pancreatic cysts (HP:0001737)2.46464731
45Abnormality of midbrain morphology (HP:0002418)2.45051937
46Molar tooth sign on MRI (HP:0002419)2.45051937
47Rhabdomyosarcoma (HP:0002859)2.44485151
48Thrombocytosis (HP:0001894)2.41025552
49Hepatoblastoma (HP:0002884)2.40987091
50IgM deficiency (HP:0002850)2.39894328
51Breast hypoplasia (HP:0003187)2.39839153
52Pancreatic fibrosis (HP:0100732)2.39692867
53Prominent nose (HP:0000448)2.39347423
54Lissencephaly (HP:0001339)2.39061537
55Occipital encephalocele (HP:0002085)2.38373595
56Facial hemangioma (HP:0000329)2.37902513
57Volvulus (HP:0002580)2.35887476
58Absent thumb (HP:0009777)2.34524116
59Short 4th metacarpal (HP:0010044)2.33888775
60Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.33888775
61Proximal placement of thumb (HP:0009623)2.32318065
62Hyperacusis (HP:0010780)2.31737988
63Cafe-au-lait spot (HP:0000957)2.29641346
64Abnormal respiratory motile cilium morphology (HP:0005938)2.29403932
65Abnormal respiratory epithelium morphology (HP:0012253)2.29403932
66Abnormality of the carotid arteries (HP:0005344)2.29343941
67Preaxial hand polydactyly (HP:0001177)2.27099235
68Glioma (HP:0009733)2.26268983
69High pitched voice (HP:0001620)2.26183109
70Retinal dysplasia (HP:0007973)2.25485546
71Neoplasm of striated muscle (HP:0009728)2.25450788
72Sloping forehead (HP:0000340)2.23079617
73Atrophy/Degeneration involving motor neurons (HP:0007373)2.22653703
74Neoplasm of the oral cavity (HP:0100649)2.22436024
75Abnormality of the aortic arch (HP:0012303)2.21482680
76Deviation of the thumb (HP:0009603)2.21267826
77Multiple enchondromatosis (HP:0005701)2.19654954
78Bone marrow hypocellularity (HP:0005528)2.17741570
79Neoplasm of the pancreas (HP:0002894)2.15384794
80True hermaphroditism (HP:0010459)2.13907305
81Abnormality of the labia minora (HP:0012880)2.13875008
82Tracheoesophageal fistula (HP:0002575)2.12536403
83Renal hypoplasia (HP:0000089)2.09865779
84Drooling (HP:0002307)2.08770536
85Abnormality of the fingertips (HP:0001211)2.08571595
86Postaxial foot polydactyly (HP:0001830)2.06590268
87Renal duplication (HP:0000075)2.05461357
88Abnormality of the renal medulla (HP:0100957)2.05207444
89Aplasia/Hypoplasia of the sternum (HP:0006714)2.04020952
90Neoplasm of the adrenal cortex (HP:0100641)2.03892805
91Amaurosis fugax (HP:0100576)2.02298658
9211 pairs of ribs (HP:0000878)2.01824615
93Horseshoe kidney (HP:0000085)2.01351753
94Slender long bone (HP:0003100)2.00485553
95Chronic bronchitis (HP:0004469)2.00326198
96Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.00144190
97Abnormality of the metopic suture (HP:0005556)1.99772660
98Abnormality of the duodenum (HP:0002246)1.99636214
99Abnormality of DNA repair (HP:0003254)1.99610557
100Atresia of the external auditory canal (HP:0000413)1.99508902
101Cystic liver disease (HP:0006706)1.95888894
102Supernumerary spleens (HP:0009799)1.95839462
103Absent radius (HP:0003974)1.95050729
104Long eyelashes (HP:0000527)1.94983668
105Aplasia/Hypoplasia of the spleen (HP:0010451)1.93604350
106Dandy-Walker malformation (HP:0001305)1.92039195
107Sclerocornea (HP:0000647)1.91444394
108Lymphoma (HP:0002665)1.89904834
109Cerebellar dysplasia (HP:0007033)1.89772335
110Bile duct proliferation (HP:0001408)1.88132469
111Abnormal biliary tract physiology (HP:0012439)1.88132469
112Recurrent viral infections (HP:0004429)1.88025155
113Poikiloderma (HP:0001029)1.87898435
114Hypoplasia of the brainstem (HP:0002365)1.87437888
115Aplasia/Hypoplasia of the brainstem (HP:0007362)1.87437888
116Excessive salivation (HP:0003781)1.86879755
117Abnormality of the lower motor neuron (HP:0002366)1.86249525
118Abnormal lung lobation (HP:0002101)1.86023222
119Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.84169112
120Malignant gastrointestinal tract tumors (HP:0006749)1.83233601
121Gastrointestinal carcinoma (HP:0002672)1.83233601
122Gait imbalance (HP:0002141)1.82448618
123Type II lissencephaly (HP:0007260)1.82384977
124Optic nerve coloboma (HP:0000588)1.80431370
125Clubbing of toes (HP:0100760)1.80210297
126Bicornuate uterus (HP:0000813)1.79902353
127Spinal muscular atrophy (HP:0007269)1.79714965
128Aplasia involving forearm bones (HP:0009822)1.79313002
129Absent forearm bone (HP:0003953)1.79313002
130Squamous cell carcinoma (HP:0002860)1.79134869
131Polymicrogyria (HP:0002126)1.77312842
132Congenital primary aphakia (HP:0007707)1.76973499
133Broad palm (HP:0001169)1.76827507
134Microretrognathia (HP:0000308)1.76725218
135Angiofibromas (HP:0010615)1.76194125
136Adenoma sebaceum (HP:0009720)1.76194125
137Vaginal atresia (HP:0000148)1.75760035
138Abnormality of the intervertebral disk (HP:0005108)1.75653039
139Anencephaly (HP:0002323)1.75298117
140Missing ribs (HP:0000921)1.75108237
141Medial flaring of the eyebrow (HP:0010747)1.74987455
142Prominent metopic ridge (HP:0005487)1.74930092
143Overlapping toe (HP:0001845)1.74802688
144Genital tract atresia (HP:0001827)1.74725063
145Acute lymphatic leukemia (HP:0006721)1.74593738
146Intestinal atresia (HP:0011100)1.73643633
147Duplicated collecting system (HP:0000081)1.73639471
148Pallor (HP:0000980)1.73101370
149Pendular nystagmus (HP:0012043)1.72531466
150Nephroblastoma (Wilms tumor) (HP:0002667)1.71764718
151Cellular immunodeficiency (HP:0005374)1.71291657
152Abnormal neuron morphology (HP:0012757)1.70950920
153Abnormality of the motor neurons (HP:0002450)1.70950920
154Facial cleft (HP:0002006)1.70547762
155Cellulitis (HP:0100658)1.70364978
156Neoplasm of the colon (HP:0100273)1.70129806
157Heterotopia (HP:0002282)1.69768393
158Urethral obstruction (HP:0000796)1.69755335
159Broad distal phalanx of finger (HP:0009836)1.68612293
160Coarctation of aorta (HP:0001680)1.68393789
161Broad alveolar ridges (HP:0000187)1.67063053
162Nephrogenic diabetes insipidus (HP:0009806)1.65696947
163Narrow forehead (HP:0000341)1.65298781
164Postaxial hand polydactyly (HP:0001162)1.64512729
165Asplenia (HP:0001746)1.62246421
166Cutaneous finger syndactyly (HP:0010554)1.61998844
167Pachygyria (HP:0001302)1.60986159
168Vitreoretinal degeneration (HP:0000655)1.59771076
169Abnormality of the antihelix (HP:0009738)1.59678363
170Triphalangeal thumb (HP:0001199)1.57575176
171Scrotal hypoplasia (HP:0000046)1.56876169
172Broad-based gait (HP:0002136)1.55139513
173Cutaneous syndactyly (HP:0012725)1.54802606
174Anophthalmia (HP:0000528)1.53503135
175Irregular epiphyses (HP:0010582)1.53207806

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.52578846
2WEE13.35744581
3BUB13.34045143
4NEK23.21969824
5CASK3.06991681
6EEF2K2.98940480
7CDK122.74496184
8MAP3K102.62112127
9MARK12.36097284
10NEK12.27788557
11PKN22.27624953
12TTK2.15286276
13MAP3K42.03454073
14PNCK1.94514197
15PASK1.94291602
16MAP4K11.92758526
17ACVR1B1.91042586
18SCYL21.84992780
19ATR1.81811800
20TESK21.79457814
21VRK21.77138493
22CDK71.74958115
23CDK41.73738026
24PLK11.73376706
25STK101.71530896
26BCR1.68125931
27TRIB31.64561410
28DYRK21.64350291
29DYRK31.61386392
30FGFR21.60996440
31RPS6KB21.56393296
32PLK41.55070080
33EIF2AK11.52988533
34CAMK1G1.50895477
35TRIM281.50437491
36MAP3K81.46639532
37WNK31.41297951
38SRPK11.39006050
39AURKB1.38616086
40BRD41.36850916
41PAK41.34783281
42ZAK1.34433908
43CHEK21.34267881
44TGFBR11.32596328
45CHEK11.31631371
46BRSK21.31236109
47TSSK61.29630098
48SMG11.29169772
49INSRR1.27636249
50EPHA41.22318254
51MAPK151.21431772
52MAP2K71.20982880
53RPS6KA41.18693959
54DYRK1B1.16989257
55FLT31.15918195
56STK41.15869621
57EIF2AK31.11801442
58BRSK11.09579339
59NME21.08121428
60NME11.07013305
61TNIK1.00851548
62BLK0.99259643
63SIK30.99069404
64EPHB10.97198920
65CCNB10.95530068
66MKNK10.95363452
67LRRK20.94986528
68BTK0.94703390
69GRK60.92016089
70CSF1R0.91492156
71TLK10.91456782
72CDK20.90201247
73ALK0.88475538
74AURKA0.87913904
75NUAK10.87903395
76CDK60.87473688
77KSR10.86467300
78PIM10.85862064
79CAMK1D0.84390963
80MAP3K70.84250888
81ATM0.83072484
82MELK0.82450996
83PLK30.80465892
84CDK30.79555402
85MTOR0.78841241
86ERN10.76706768
87CDK190.76173391
88PRKDC0.75940848
89ICK0.75257112
90TESK10.75241216
91STK30.74206145
92BMPR1B0.72662140
93PRKAA10.72380356
94DYRK1A0.72329724
95MAP2K40.71072988
96CDK80.70143640
97EPHB20.68427215
98VRK10.68198063
99MAPK130.67753748
100MAPKAPK30.66917815
101KIT0.65693948
102PRKD30.65467013
103CSNK1E0.64504459
104TAF10.64067701
105ZAP700.63981577
106LATS10.63837313
107MAP2K30.62459751
108CDK10.60344673
109LMTK20.59028720
110GSK3B0.58284648
111CLK10.56028126
112UHMK10.53574431
113ERBB30.52400161
114CSNK1G30.51930287
115TAOK10.50415528
116JAK30.50155702
117AKT20.49749223
118MAPK140.49708391
119PAK10.48256192
120TYK20.47236179
121MAP2K60.47079300
122MARK20.46280751
123MAP4K20.46071079
124WNK40.45126149
125TAOK20.45069529
126MATK0.45066551
127CSNK1D0.44899822
128MAPK90.44877835
129PAK30.44724273
130PDK30.44574057
131PDK40.44574057
132DAPK10.44433908
133MAPK80.44342167
134FRK0.43804667
135CSNK1G10.43309944
136CSNK1G20.42846235
137PTK60.42035643
138CDK180.41519864
139PRKD20.41186044
140MKNK20.40091819
141SYK0.39158234
142TYRO30.38792926
143MAP3K110.38552585
144CSNK2A20.38070055
145PRKCI0.37835527
146SIK20.34918027
147MAPK110.34405923
148KDR0.32666377
149CSNK2A10.32393273
150BCKDK0.31525326
151CDK90.31496509
152EPHA20.28471865
153RAF10.27811066
154TTN0.27450338
155MAP3K60.27404787
156STK160.27368645

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.24460762
2Mismatch repair_Homo sapiens_hsa034304.15673868
3Base excision repair_Homo sapiens_hsa034103.38002247
4Spliceosome_Homo sapiens_hsa030403.08051883
5Cell cycle_Homo sapiens_hsa041102.93319331
6RNA transport_Homo sapiens_hsa030132.91369848
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.90423165
8Homologous recombination_Homo sapiens_hsa034402.73615351
9Nucleotide excision repair_Homo sapiens_hsa034202.54065063
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.50705686
11One carbon pool by folate_Homo sapiens_hsa006702.43037048
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.09578100
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.08568318
14Fanconi anemia pathway_Homo sapiens_hsa034602.06814498
15mRNA surveillance pathway_Homo sapiens_hsa030152.05457970
16Ribosome_Homo sapiens_hsa030102.03358887
17RNA polymerase_Homo sapiens_hsa030202.02783312
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.90863643
19Pyrimidine metabolism_Homo sapiens_hsa002401.90727715
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.87828510
21Non-homologous end-joining_Homo sapiens_hsa034501.87552719
22Steroid biosynthesis_Homo sapiens_hsa001001.83839528
23RNA degradation_Homo sapiens_hsa030181.81463914
24p53 signaling pathway_Homo sapiens_hsa041151.63008208
25Proteasome_Homo sapiens_hsa030501.55013351
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.53913458
27Nicotine addiction_Homo sapiens_hsa050331.47696161
28Basal transcription factors_Homo sapiens_hsa030221.47020186
29Axon guidance_Homo sapiens_hsa043601.35247718
30Butanoate metabolism_Homo sapiens_hsa006501.33130637
31Herpes simplex infection_Homo sapiens_hsa051681.23618414
32Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.22603266
33Epstein-Barr virus infection_Homo sapiens_hsa051691.22345389
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.15784729
35Viral carcinogenesis_Homo sapiens_hsa052031.14729602
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.13431320
37Primary immunodeficiency_Homo sapiens_hsa053401.12503064
38Oocyte meiosis_Homo sapiens_hsa041141.12376229
39Chronic myeloid leukemia_Homo sapiens_hsa052201.10198019
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08677889
41Notch signaling pathway_Homo sapiens_hsa043301.08314411
42HTLV-I infection_Homo sapiens_hsa051661.06142263
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05203839
44Antigen processing and presentation_Homo sapiens_hsa046121.04432301
45Systemic lupus erythematosus_Homo sapiens_hsa053220.99356751
46Thyroid cancer_Homo sapiens_hsa052160.99060921
47Taste transduction_Homo sapiens_hsa047420.98317180
48Fatty acid metabolism_Homo sapiens_hsa012120.97691579
49Wnt signaling pathway_Homo sapiens_hsa043100.96117049
50MicroRNAs in cancer_Homo sapiens_hsa052060.94942779
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93688922
52Fatty acid elongation_Homo sapiens_hsa000620.93061561
53Purine metabolism_Homo sapiens_hsa002300.92047163
54Pentose phosphate pathway_Homo sapiens_hsa000300.92014337
55Small cell lung cancer_Homo sapiens_hsa052220.89216127
56Colorectal cancer_Homo sapiens_hsa052100.88844833
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88837174
58Protein export_Homo sapiens_hsa030600.87982506
59Biosynthesis of amino acids_Homo sapiens_hsa012300.86669502
60B cell receptor signaling pathway_Homo sapiens_hsa046620.84869336
61Propanoate metabolism_Homo sapiens_hsa006400.83469811
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82967390
63AMPK signaling pathway_Homo sapiens_hsa041520.80251651
64Acute myeloid leukemia_Homo sapiens_hsa052210.79625529
65mTOR signaling pathway_Homo sapiens_hsa041500.79573739
66Shigellosis_Homo sapiens_hsa051310.78579274
67Non-small cell lung cancer_Homo sapiens_hsa052230.77031914
68N-Glycan biosynthesis_Homo sapiens_hsa005100.76840812
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76378131
70Apoptosis_Homo sapiens_hsa042100.75191230
71Insulin secretion_Homo sapiens_hsa049110.73291211
72Selenocompound metabolism_Homo sapiens_hsa004500.72605386
73Measles_Homo sapiens_hsa051620.71907757
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71268180
75Tight junction_Homo sapiens_hsa045300.71258480
76Legionellosis_Homo sapiens_hsa051340.71168844
77Hepatitis B_Homo sapiens_hsa051610.70877445
78Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70586720
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70176947
80Viral myocarditis_Homo sapiens_hsa054160.69160080
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68807024
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67179467
83Dopaminergic synapse_Homo sapiens_hsa047280.66681810
84Pancreatic cancer_Homo sapiens_hsa052120.66037254
85Lysine degradation_Homo sapiens_hsa003100.65725829
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65457221
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.63483143
88Huntingtons disease_Homo sapiens_hsa050160.63205253
89Cysteine and methionine metabolism_Homo sapiens_hsa002700.61606393
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58999779
91Basal cell carcinoma_Homo sapiens_hsa052170.57574183
92Influenza A_Homo sapiens_hsa051640.57212971
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55078730
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55039534
95Hippo signaling pathway_Homo sapiens_hsa043900.54979329
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.54527912
97Bladder cancer_Homo sapiens_hsa052190.53726306
98Vitamin B6 metabolism_Homo sapiens_hsa007500.53239052
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52808992
100HIF-1 signaling pathway_Homo sapiens_hsa040660.51277210
101Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51193506
102Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49597332
103Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49220108
1042-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49165381
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47439076
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46578968
107TGF-beta signaling pathway_Homo sapiens_hsa043500.46454240
108T cell receptor signaling pathway_Homo sapiens_hsa046600.46195835
109Long-term depression_Homo sapiens_hsa047300.45953120
110Cocaine addiction_Homo sapiens_hsa050300.45921683
111GABAergic synapse_Homo sapiens_hsa047270.45879979
112Leishmaniasis_Homo sapiens_hsa051400.45783158
113Endometrial cancer_Homo sapiens_hsa052130.45372451
114Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45260052
115Thyroid hormone synthesis_Homo sapiens_hsa049180.45131052
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.44766336
117Pyruvate metabolism_Homo sapiens_hsa006200.43703180
118Glutamatergic synapse_Homo sapiens_hsa047240.43236804
119Folate biosynthesis_Homo sapiens_hsa007900.42019783
120Phototransduction_Homo sapiens_hsa047440.41755735
121Adherens junction_Homo sapiens_hsa045200.41274100
122Inositol phosphate metabolism_Homo sapiens_hsa005620.41225236
123Pathways in cancer_Homo sapiens_hsa052000.41037258
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40824547
125VEGF signaling pathway_Homo sapiens_hsa043700.40588172
126Carbon metabolism_Homo sapiens_hsa012000.40043519
127Cyanoamino acid metabolism_Homo sapiens_hsa004600.40001548
128Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39951738
129Alcoholism_Homo sapiens_hsa050340.38469988
130Melanogenesis_Homo sapiens_hsa049160.37197671
131Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.36995871
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36885902
133Cholinergic synapse_Homo sapiens_hsa047250.36421504
134Metabolic pathways_Homo sapiens_hsa011000.36261270
135Sulfur relay system_Homo sapiens_hsa041220.35624960
136Morphine addiction_Homo sapiens_hsa050320.35221430
137Ether lipid metabolism_Homo sapiens_hsa005650.34955580
138Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34192965
139Glucagon signaling pathway_Homo sapiens_hsa049220.34033243
140Drug metabolism - other enzymes_Homo sapiens_hsa009830.33665967
141Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33369710
142Jak-STAT signaling pathway_Homo sapiens_hsa046300.33110474
143Leukocyte transendothelial migration_Homo sapiens_hsa046700.31970108
144Cardiac muscle contraction_Homo sapiens_hsa042600.30899339
145Proteoglycans in cancer_Homo sapiens_hsa052050.30110155
146Hematopoietic cell lineage_Homo sapiens_hsa046400.29961016
147Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29057152
148Circadian rhythm_Homo sapiens_hsa047100.28984539
149Hedgehog signaling pathway_Homo sapiens_hsa043400.28467517
150Toxoplasmosis_Homo sapiens_hsa051450.28346823
151Choline metabolism in cancer_Homo sapiens_hsa052310.27953970
152Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27574503
153Fructose and mannose metabolism_Homo sapiens_hsa000510.24639716
154RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.24498985
155Galactose metabolism_Homo sapiens_hsa000520.24015857
156FoxO signaling pathway_Homo sapiens_hsa040680.23741044

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