N4BP2L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)6.11739102
2central nervous system myelination (GO:0022010)6.11739102
3neuron cell-cell adhesion (GO:0007158)5.99436072
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.42589667
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.29735757
6dopamine biosynthetic process (GO:0042416)5.21564085
7energy coupled proton transport, down electrochemical gradient (GO:0015985)5.03799100
8ATP synthesis coupled proton transport (GO:0015986)5.03799100
9establishment of protein localization to Golgi (GO:0072600)4.75826729
10presynaptic membrane assembly (GO:0097105)4.64151206
11establishment of protein localization to mitochondrial membrane (GO:0090151)4.48925296
12long-chain fatty acid biosynthetic process (GO:0042759)4.48346367
13presynaptic membrane organization (GO:0097090)4.45183330
14fatty acid elongation (GO:0030497)4.37526691
15negative regulation of neurotransmitter transport (GO:0051589)4.35247540
16respiratory electron transport chain (GO:0022904)4.33908247
17dopamine transport (GO:0015872)4.29504474
18electron transport chain (GO:0022900)4.23966117
19protein targeting to Golgi (GO:0000042)4.22837893
20neurotransmitter catabolic process (GO:0042135)4.01840045
21neural tube formation (GO:0001841)3.98054743
22neuron remodeling (GO:0016322)3.97002802
23neuron recognition (GO:0008038)3.95304717
24retrograde transport, vesicle recycling within Golgi (GO:0000301)3.95220525
25positive regulation of synapse assembly (GO:0051965)3.86701918
26regulation of catecholamine metabolic process (GO:0042069)3.85722940
27regulation of dopamine metabolic process (GO:0042053)3.85722940
28transmission of nerve impulse (GO:0019226)3.79383030
29protein K11-linked deubiquitination (GO:0035871)3.76352641
30myelination (GO:0042552)3.69490626
31protein neddylation (GO:0045116)3.66449100
32ensheathment of neurons (GO:0007272)3.62044065
33axon ensheathment (GO:0008366)3.62044065
34epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.61838363
35mating behavior (GO:0007617)3.59423532
36monoubiquitinated protein deubiquitination (GO:0035520)3.54639148
37substantia nigra development (GO:0021762)3.54212418
38phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.52049814
39protein prenylation (GO:0018342)3.46995899
40prenylation (GO:0097354)3.46995899
41glycerophospholipid catabolic process (GO:0046475)3.43408186
42synaptic transmission, dopaminergic (GO:0001963)3.42455093
43protein localization to Golgi apparatus (GO:0034067)3.41971912
44negative regulation of neurotransmitter secretion (GO:0046929)3.37256367
45gamma-aminobutyric acid signaling pathway (GO:0007214)3.35407328
46chaperone-mediated protein transport (GO:0072321)3.31854913
47catecholamine biosynthetic process (GO:0042423)3.30596683
48catechol-containing compound biosynthetic process (GO:0009713)3.30596683
49activated T cell proliferation (GO:0050798)3.24812883
50cholesterol biosynthetic process (GO:0006695)3.24176070
51cellular response to ethanol (GO:0071361)3.22579666
52regulation of protein kinase A signaling (GO:0010738)3.20913255
53ionotropic glutamate receptor signaling pathway (GO:0035235)3.20905229
54axonal fasciculation (GO:0007413)3.20370408
55phenol-containing compound catabolic process (GO:0019336)3.20181088
56response to pheromone (GO:0019236)3.17587191
57interkinetic nuclear migration (GO:0022027)3.17238011
58regulation of pigment cell differentiation (GO:0050932)3.14550060
59neuronal action potential propagation (GO:0019227)3.14258636
60vocalization behavior (GO:0071625)3.13869257
61cellular response to epinephrine stimulus (GO:0071872)3.13621723
62L-fucose catabolic process (GO:0042355)3.13378052
63fucose catabolic process (GO:0019317)3.13378052
64L-fucose metabolic process (GO:0042354)3.13378052
65glutamate receptor signaling pathway (GO:0007215)3.13238847
66negative regulation of translation, ncRNA-mediated (GO:0040033)3.11227480
67regulation of translation, ncRNA-mediated (GO:0045974)3.11227480
68negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.11227480
69catecholamine transport (GO:0051937)3.09613572
70negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.03754659
71response to redox state (GO:0051775)3.03662076
72histone H3-K4 trimethylation (GO:0080182)3.02908413
73regulation of collateral sprouting (GO:0048670)3.02280478
74positive regulation of developmental pigmentation (GO:0048087)2.99297167
75synaptic vesicle exocytosis (GO:0016079)2.98191799
76response to methylmercury (GO:0051597)2.97194750
77negative regulation of protein localization to cell surface (GO:2000009)2.97116194
78negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.96249037
79regulation of vesicle fusion (GO:0031338)2.95625412
80regulation of B cell receptor signaling pathway (GO:0050855)2.94560801
81response to epinephrine (GO:0071871)2.93260379
82positive regulation of granulocyte differentiation (GO:0030854)2.92169884
83inner mitochondrial membrane organization (GO:0007007)2.91985838
84regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.91710743
85hydrogen ion transmembrane transport (GO:1902600)2.89907267
86regulation of protein glycosylation (GO:0060049)2.86413494
87negative regulation of cytosolic calcium ion concentration (GO:0051481)2.85221338
88cilium or flagellum-dependent cell motility (GO:0001539)2.85124223
89protein localization to synapse (GO:0035418)2.85025643
90cellular ketone body metabolic process (GO:0046950)2.84691257
91axoneme assembly (GO:0035082)2.84597321
92neuron-neuron synaptic transmission (GO:0007270)2.82073694
93regulation of synapse assembly (GO:0051963)2.81470516
94neurotransmitter biosynthetic process (GO:0042136)2.80628213
95sterol biosynthetic process (GO:0016126)2.80530724
96regulation of establishment of cell polarity (GO:2000114)2.80240887
97photoreceptor cell maintenance (GO:0045494)2.76912650
98response to cocaine (GO:0042220)2.76796946
99regulation of glutamate secretion (GO:0014048)2.76046040
100isoprenoid biosynthetic process (GO:0008299)2.75992024
101dendritic spine morphogenesis (GO:0060997)2.75867507
102regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.75526260
103detection of light stimulus involved in visual perception (GO:0050908)2.74786230
104detection of light stimulus involved in sensory perception (GO:0050962)2.74786230
105negative regulation of synaptic transmission, GABAergic (GO:0032229)2.74021621
106regulation of glucokinase activity (GO:0033131)2.72996309
107regulation of hexokinase activity (GO:1903299)2.72996309
108adult walking behavior (GO:0007628)2.72731874
109postsynaptic membrane organization (GO:0001941)2.71472697
110response to histamine (GO:0034776)2.70892029
111synapse assembly (GO:0007416)2.70558634
112positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.70096469
113proton transport (GO:0015992)2.69872672
114behavioral response to cocaine (GO:0048148)2.69517958
115negative regulation of axon extension (GO:0030517)2.68991121
116dopamine metabolic process (GO:0042417)2.68975465
117calcium-mediated signaling using intracellular calcium source (GO:0035584)2.68611647
118histone H2B ubiquitination (GO:0033523)2.66203033
119protein K63-linked deubiquitination (GO:0070536)2.65295268
120signal peptide processing (GO:0006465)2.64862717
121oligodendrocyte differentiation (GO:0048709)2.64485426
122kidney morphogenesis (GO:0060993)2.64476490
123epithelial cilium movement (GO:0003351)2.64470313
124positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.63549744
125alkaloid metabolic process (GO:0009820)2.63338599
126hydrogen transport (GO:0006818)2.63188963
127indolalkylamine metabolic process (GO:0006586)2.62417117
128intra-Golgi vesicle-mediated transport (GO:0006891)2.61942690
129regulation of feeding behavior (GO:0060259)2.60074846
130peptidyl-lysine trimethylation (GO:0018023)2.59376394
131ATP hydrolysis coupled proton transport (GO:0015991)2.56956528
132energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.56956528
133membrane hyperpolarization (GO:0060081)2.56708081
134limb bud formation (GO:0060174)2.56395098
135regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.55952482
136neural nucleus development (GO:0048857)2.55293406
137negative regulation of synaptic transmission (GO:0050805)2.55286020
138GTP biosynthetic process (GO:0006183)2.55172181
139ketone body metabolic process (GO:1902224)2.54495629
140detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.54491431
141cilium movement (GO:0003341)2.54013710
142synaptic transmission, glutamatergic (GO:0035249)2.53611826
143protein targeting to vacuole (GO:0006623)2.53187020
144protein targeting to lysosome (GO:0006622)2.53187020
145establishment of protein localization to vacuole (GO:0072666)2.53187020
146protein K48-linked deubiquitination (GO:0071108)2.53139156
147Golgi to endosome transport (GO:0006895)2.52597878
148amyloid precursor protein metabolic process (GO:0042982)2.51000593
149cilium organization (GO:0044782)2.50983725
150neuronal ion channel clustering (GO:0045161)2.50557641
151early endosome to late endosome transport (GO:0045022)2.50134335
152cilium morphogenesis (GO:0060271)2.50124086
153regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.49667324
154protein localization to cilium (GO:0061512)2.49136642
155histone mRNA catabolic process (GO:0071044)2.49125612
156inositol phosphate catabolic process (GO:0071545)2.48957888
157dendrite development (GO:0016358)2.48619985
158locomotory exploration behavior (GO:0035641)2.48358382
159membrane assembly (GO:0071709)2.46547030
160cilium assembly (GO:0042384)2.46506931
161polyol catabolic process (GO:0046174)2.44611233
162indole-containing compound catabolic process (GO:0042436)2.40891929
163indolalkylamine catabolic process (GO:0046218)2.40891929
164tryptophan catabolic process (GO:0006569)2.40891929
165dentate gyrus development (GO:0021542)2.38564301
166cAMP catabolic process (GO:0006198)2.38525963
167regulation of establishment or maintenance of cell polarity (GO:0032878)2.36373354
168positive regulation of glycolytic process (GO:0045821)2.34384466
169reflex (GO:0060004)2.34016162
170regulation of gamma-delta T cell differentiation (GO:0045586)2.33413872
171cyclic nucleotide catabolic process (GO:0009214)2.33122141
172positive regulation of gamma-delta T cell activation (GO:0046645)2.33095866
173regulation of memory T cell differentiation (GO:0043380)2.29212259
174lipid translocation (GO:0034204)2.29082958
175phospholipid translocation (GO:0045332)2.29082958
176phospholipid homeostasis (GO:0055091)2.27762361
177nucleus localization (GO:0051647)2.26857226
178regulation of sarcomere organization (GO:0060297)2.25372307
179tryptophan metabolic process (GO:0006568)2.25286403
180negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.24785448
181macroautophagy (GO:0016236)2.24153352
182regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.23770552
183positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.23770552
184positive regulation of mRNA catabolic process (GO:0061014)2.23414847
185regulation of relaxation of muscle (GO:1901077)2.22493560
186interferon-gamma production (GO:0032609)2.21748520
187histone H3-K9 methylation (GO:0051567)2.20617324
188negative regulation of complement activation (GO:0045916)2.19063170
189regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.18679998
190positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.18679998
191embryonic epithelial tube formation (GO:0001838)2.18328471
192regulation of MHC class I biosynthetic process (GO:0045343)2.18156959
193regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.17446501
194behavioral response to nicotine (GO:0035095)2.16645481
195prostate gland growth (GO:0060736)2.16495285
196intraciliary transport (GO:0042073)2.16209249
197phosphorylated carbohydrate dephosphorylation (GO:0046838)2.15627440

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.75607611
2GBX2_23144817_ChIP-Seq_PC3_Human3.66151239
3TAF15_26573619_Chip-Seq_HEK293_Human3.62242514
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.02832462
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.65117933
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.59708874
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.47619855
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.46024634
9CTBP1_25329375_ChIP-Seq_LNCAP_Human2.38711566
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.33880546
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.21155361
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.21096788
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.18230343
14BMI1_23680149_ChIP-Seq_NPCS_Mouse2.14916908
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.13231956
16FUS_26573619_Chip-Seq_HEK293_Human2.12537000
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.10800137
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.07031829
19VDR_22108803_ChIP-Seq_LS180_Human2.06696161
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.05509501
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.04947885
22JARID2_20075857_ChIP-Seq_MESCs_Mouse2.02150126
23RNF2_18974828_ChIP-Seq_MESCs_Mouse2.01775962
24EZH2_18974828_ChIP-Seq_MESCs_Mouse2.01775962
25SMAD_19615063_ChIP-ChIP_OVARY_Human1.99120917
26SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.98251699
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.98186664
28BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.97438886
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.96020289
30AR_21572438_ChIP-Seq_LNCaP_Human1.95797718
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.95022246
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.91198180
33IRF8_22096565_ChIP-ChIP_GC-B_Human1.90434059
34P300_19829295_ChIP-Seq_ESCs_Human1.88869698
35* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.88695295
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.85751524
37SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.82192699
38OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.78112596
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.77349922
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.75597349
41ER_23166858_ChIP-Seq_MCF-7_Human1.74553442
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.73520621
43STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.72572293
44REST_21632747_ChIP-Seq_MESCs_Mouse1.72095251
45IGF1R_20145208_ChIP-Seq_DFB_Human1.72032011
46EZH2_27294783_Chip-Seq_ESCs_Mouse1.71298827
47BCAT_22108803_ChIP-Seq_LS180_Human1.64860348
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.61062757
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.59691156
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.57510739
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.55043203
52* SMAD3_21741376_ChIP-Seq_EPCs_Human1.54253724
53SMAD4_21799915_ChIP-Seq_A2780_Human1.53808068
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.50737796
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49176154
56CBP_20019798_ChIP-Seq_JUKART_Human1.49176154
57CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.48943342
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.48865282
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47505532
60RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46560936
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.46360906
62PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46192438
63CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.43737823
64RNF2_27304074_Chip-Seq_NSC_Mouse1.43118510
65NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41130638
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40533996
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40517660
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.38931329
69ZNF274_21170338_ChIP-Seq_K562_Hela1.36369113
70FLI1_21867929_ChIP-Seq_TH2_Mouse1.33174112
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.32349257
72POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31977973
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31159733
74EWS_26573619_Chip-Seq_HEK293_Human1.30929691
75CRX_20693478_ChIP-Seq_RETINA_Mouse1.30697035
76DROSHA_22980978_ChIP-Seq_HELA_Human1.30536424
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30285176
78PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29739947
79FLI1_27457419_Chip-Seq_LIVER_Mouse1.29523768
80TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.28384224
81TP53_16413492_ChIP-PET_HCT116_Human1.25381365
82TCF4_22108803_ChIP-Seq_LS180_Human1.24411799
83EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.24119350
84SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23502249
85OCT4_21477851_ChIP-Seq_ESCs_Mouse1.23482323
86* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23475217
87CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23387375
88REST_18959480_ChIP-ChIP_MESCs_Mouse1.22279757
89CMYC_18555785_Chip-Seq_ESCs_Mouse1.21460239
90RUNX2_22187159_ChIP-Seq_PCA_Human1.20257196
91CDX2_22108803_ChIP-Seq_LS180_Human1.19557039
92STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.17093116
93TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16665792
94ARNT_22903824_ChIP-Seq_MCF-7_Human1.16396087
95PRDM14_20953172_ChIP-Seq_ESCs_Human1.16357866
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16256951
97JUN_21703547_ChIP-Seq_K562_Human1.15619885
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15506024
99MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15030682
100ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14650130
101E2F1_18555785_Chip-Seq_ESCs_Mouse1.14461858
102ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.14059331
103SUZ12_18555785_Chip-Seq_ESCs_Mouse1.14038939
104P53_22387025_ChIP-Seq_ESCs_Mouse1.13775910
105SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.13709016
106P300_18555785_Chip-Seq_ESCs_Mouse1.13625169
107FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13401690
108RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.13233494
109NANOG_19829295_ChIP-Seq_ESCs_Human1.12173683
110SOX2_19829295_ChIP-Seq_ESCs_Human1.12173683
111MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12027514
112TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.11761142
113IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.11068489
114RUNX_20019798_ChIP-Seq_JUKART_Human1.10966355
115EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.10835432
116SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09880653
117TAL1_26923725_Chip-Seq_HPCs_Mouse1.09051468
118HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.08948224
119TCF4_23295773_ChIP-Seq_U87_Human1.08933580
120FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08426391
121* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08378850
122FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08081062
123TP53_18474530_ChIP-ChIP_U2OS_Human1.05612563
124AHR_22903824_ChIP-Seq_MCF-7_Human1.04901092
125* SMAD4_21741376_ChIP-Seq_EPCs_Human1.04878165
126STAT3_23295773_ChIP-Seq_U87_Human1.04012606
127POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03456080
128TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03456080
129NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03354104
130NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03354104
131BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03063287
132MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03045205
133WT1_19549856_ChIP-ChIP_CCG9911_Human1.02961886
134EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02487803
135* AR_25329375_ChIP-Seq_VCAP_Human1.02254513
136OCT4_18555785_Chip-Seq_ESCs_Mouse1.02126567
137EZH2_27294783_Chip-Seq_NPCs_Mouse1.00732022
138PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00583068
139SOX2_21211035_ChIP-Seq_LN229_Gbm1.00079305
140SOX2_18555785_Chip-Seq_ESCs_Mouse1.00012588
141STAT3_18555785_Chip-Seq_ESCs_Mouse0.99389052
142KDM2B_26808549_Chip-Seq_REH_Human0.98855859

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern6.16281436
2MP0000569_abnormal_digit_pigmentation5.25912784
3MP0001529_abnormal_vocalization4.01741390
4MP0003787_abnormal_imprinting3.68944788
5MP0001905_abnormal_dopamine_level3.37146570
6MP0006276_abnormal_autonomic_nervous3.34974176
7MP0005409_darkened_coat_color3.11273352
8MP0008877_abnormal_DNA_methylation2.99427844
9MP0003195_calcinosis2.87042236
10MP0002064_seizures2.76417787
11MP0004859_abnormal_synaptic_plasticity2.70063024
12MP0003635_abnormal_synaptic_transmissio2.66656869
13MP0004270_analgesia2.65827185
14MP0005423_abnormal_somatic_nervous2.64506172
15MP0009745_abnormal_behavioral_response2.58855623
16MP0001440_abnormal_grooming_behavior2.51114052
17MP0009379_abnormal_foot_pigmentation2.50210276
18MP0001486_abnormal_startle_reflex2.45058796
19MP0002272_abnormal_nervous_system2.40141934
20MP0009046_muscle_twitch2.39808385
21MP0000920_abnormal_myelination2.36686977
22MP0004742_abnormal_vestibular_system2.31947943
23MP0004043_abnormal_pH_regulation2.30657863
24MP0002572_abnormal_emotion/affect_behav2.28564518
25MP0005174_abnormal_tail_pigmentation2.25524534
26MP0002822_catalepsy2.25457949
27MP0001968_abnormal_touch/_nociception2.14679388
28MP0000778_abnormal_nervous_system2.12797383
29MP0003646_muscle_fatigue2.12640698
30MP0001188_hyperpigmentation2.11084812
31MP0004142_abnormal_muscle_tone2.09805337
32MP0000427_abnormal_hair_cycle2.07849406
33MP0008057_abnormal_DNA_replication2.01845124
34MP0002063_abnormal_learning/memory/cond2.00900538
35MP0002734_abnormal_mechanical_nocicepti1.95774995
36MP0001501_abnormal_sleep_pattern1.89948650
37MP0005075_abnormal_melanosome_morpholog1.88761333
38MP0002736_abnormal_nociception_after1.83253722
39MP0004924_abnormal_behavior1.82614263
40MP0005386_behavior/neurological_phenoty1.82614263
41MP0002009_preneoplasia1.81073402
42MP0002735_abnormal_chemical_nociception1.77508590
43MP0002067_abnormal_sensory_capabilities1.77107938
44MP0005171_absent_coat_pigmentation1.73221248
45MP0002733_abnormal_thermal_nociception1.70956778
46MP0001970_abnormal_pain_threshold1.66297031
47MP0002184_abnormal_innervation1.62848780
48MP0002928_abnormal_bile_duct1.60731091
49MP0006054_spinal_hemorrhage1.56284860
50MP0003724_increased_susceptibility_to1.51912872
51MP0002557_abnormal_social/conspecific_i1.51552253
52MP0005551_abnormal_eye_electrophysiolog1.48250142
53MP0000383_abnormal_hair_follicle1.48099093
54MP0003136_yellow_coat_color1.48006277
55MP0003329_amyloid_beta_deposits1.47543789
56MP0001986_abnormal_taste_sensitivity1.46397415
57MP0003122_maternal_imprinting1.45832764
58MP0002166_altered_tumor_susceptibility1.42636907
59MP0001835_abnormal_antigen_presentation1.41322389
60MP0003252_abnormal_bile_duct1.38324557
61MP0005379_endocrine/exocrine_gland_phen1.37338244
62MP0004484_altered_response_of1.34365148
63MP0004215_abnormal_myocardial_fiber1.34249479
64MP0003121_genomic_imprinting1.34082839
65MP0000462_abnormal_digestive_system1.33731587
66MP0004145_abnormal_muscle_electrophysio1.30854696
67MP0004885_abnormal_endolymph1.30615921
68MP0002882_abnormal_neuron_morphology1.29938395
69MP0005410_abnormal_fertilization1.29510768
70MP0006072_abnormal_retinal_apoptosis1.29093636
71MP0003690_abnormal_glial_cell1.27623948
72MP0002066_abnormal_motor_capabilities/c1.26762704
73MP0000955_abnormal_spinal_cord1.25556710
74MP0003045_fibrosis1.24999554
75MP0001485_abnormal_pinna_reflex1.24244054
76MP0003634_abnormal_glial_cell1.24104472
77MP0000015_abnormal_ear_pigmentation1.22765354
78MP0005310_abnormal_salivary_gland1.21675360
79MP0002229_neurodegeneration1.20759626
80MP0001984_abnormal_olfaction1.19773135
81MP0002396_abnormal_hematopoietic_system1.17113984
82MP0001963_abnormal_hearing_physiology1.14793169
83MP0002752_abnormal_somatic_nervous1.13776783
84MP0003632_abnormal_nervous_system1.09544872
85MP0003763_abnormal_thymus_physiology1.08703960
86MP0010678_abnormal_skin_adnexa1.08206684
87MP0002693_abnormal_pancreas_physiology1.07967505
88MP0001800_abnormal_humoral_immune1.07482994
89MP0008995_early_reproductive_senescence1.04276992
90MP0002095_abnormal_skin_pigmentation1.02737515
91MP0004130_abnormal_muscle_cell1.02087972
92MP0000631_abnormal_neuroendocrine_gland1.01649147
93MP0001502_abnormal_circadian_rhythm1.00530905
94MP0002102_abnormal_ear_morphology0.99069921
95MP0002909_abnormal_adrenal_gland0.97037547
96MP0002163_abnormal_gland_morphology0.95468718
97MP0005646_abnormal_pituitary_gland0.94697649
98MP0005645_abnormal_hypothalamus_physiol0.94676375
99MP0000026_abnormal_inner_ear0.92519412
100MP0002168_other_aberrant_phenotype0.92312853
101MP0002152_abnormal_brain_morphology0.91551677
102MP0005671_abnormal_response_to0.91425913
103MP0003631_nervous_system_phenotype0.89715087
104MP0003938_abnormal_ear_development0.89482598
105MP0002876_abnormal_thyroid_physiology0.88738219
106MP0002938_white_spotting0.88537695
107MP0000371_diluted_coat_color0.88250740
108MP0002837_dystrophic_cardiac_calcinosis0.87838221
109MP0000013_abnormal_adipose_tissue0.87768698
110MP0001664_abnormal_digestion0.86927728
111MP0005253_abnormal_eye_physiology0.85921780
112MP0005220_abnormal_exocrine_pancreas0.85919507
113MP0008569_lethality_at_weaning0.85195755
114MP0008872_abnormal_physiological_respon0.84255455
115MP0000230_abnormal_systemic_arterial0.83640859
116MP0004147_increased_porphyrin_level0.83447719
117MP0003656_abnormal_erythrocyte_physiolo0.83369655
118MP0005266_abnormal_metabolism0.80244185
119MP0003011_delayed_dark_adaptation0.79587519
120MP0005195_abnormal_posterior_eye0.79318738
121MP0001756_abnormal_urination0.78733900
122MP0010329_abnormal_lipoprotein_level0.78375314
123MP0003890_abnormal_embryonic-extraembry0.77979227
124MP0009780_abnormal_chondrocyte_physiolo0.77722245
125MP0004381_abnormal_hair_follicle0.77477307
126MP0003866_abnormal_defecation0.77266945
127MP0002006_tumorigenesis0.76801074
128MP0004084_abnormal_cardiac_muscle0.75210318
129MP0005367_renal/urinary_system_phenotyp0.74141348
130MP0000516_abnormal_urinary_system0.74141348
131MP0002078_abnormal_glucose_homeostasis0.73560874
132MP0005389_reproductive_system_phenotype0.73560152
133MP0002751_abnormal_autonomic_nervous0.73502521
134MP0005535_abnormal_body_temperature0.73067822
135MP0000372_irregular_coat_pigmentation0.72022721
136MP0001661_extended_life_span0.71825186
137MP0008775_abnormal_heart_ventricle0.71640790
138MP0005167_abnormal_blood-brain_barrier0.70526611
139MP0010386_abnormal_urinary_bladder0.70215157
140MP0003633_abnormal_nervous_system0.69406785
141MP0001324_abnormal_eye_pigmentation0.68900946
142MP0004811_abnormal_neuron_physiology0.68684983
143MP0003137_abnormal_impulse_conducting0.67488447
144MP0002090_abnormal_vision0.65531222
145MP0001299_abnormal_eye_distance/0.64221392
146MP0001727_abnormal_embryo_implantation0.63909730
147MP0002069_abnormal_eating/drinking_beha0.63302514
148MP0001943_abnormal_respiration0.63127967
149MP0002638_abnormal_pupillary_reflex0.60714114
150MP0004085_abnormal_heartbeat0.59237488
151MP0005394_taste/olfaction_phenotype0.58809538
152MP0005499_abnormal_olfactory_system0.58809538
153MP0000747_muscle_weakness0.57548476
154MP0001346_abnormal_lacrimal_gland0.57424216
155MP0003950_abnormal_plasma_membrane0.56907922
156MP0001340_abnormal_eyelid_morphology0.55968078
157MP0002332_abnormal_exercise_endurance0.55167725
158MP0001177_atelectasis0.53991743

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.57226809
2Limb dystonia (HP:0002451)4.30349895
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.22186355
4Degeneration of the lateral corticospinal tracts (HP:0002314)4.22186355
5Pancreatic cysts (HP:0001737)4.15042603
6Neurofibrillary tangles (HP:0002185)4.06850522
7Sensory axonal neuropathy (HP:0003390)4.01040544
8Progressive macrocephaly (HP:0004481)3.95338129
9Abnormality of the renal cortex (HP:0011035)3.92694866
10Mitochondrial inheritance (HP:0001427)3.91896560
11Increased hepatocellular lipid droplets (HP:0006565)3.79399546
12Abnormal mitochondria in muscle tissue (HP:0008316)3.78458031
13Pancreatic fibrosis (HP:0100732)3.64558805
14Renal Fanconi syndrome (HP:0001994)3.59328770
15True hermaphroditism (HP:0010459)3.52970562
16Parakeratosis (HP:0001036)3.50071431
17Nephronophthisis (HP:0000090)3.49319642
18Cerebral inclusion bodies (HP:0100314)3.45658692
19Acute encephalopathy (HP:0006846)3.45599195
20Gaze-evoked nystagmus (HP:0000640)3.44201482
21Abnormality of the renal medulla (HP:0100957)3.35160658
22Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.34047265
23Abnormality of midbrain morphology (HP:0002418)3.26782025
24Molar tooth sign on MRI (HP:0002419)3.26782025
25Peripheral hypomyelination (HP:0007182)3.22959467
26Atonic seizures (HP:0010819)3.22655614
27Focal motor seizures (HP:0011153)3.22288474
28Thyroiditis (HP:0100646)3.21630617
29Abnormality of the corticospinal tract (HP:0002492)3.20707210
30Chronic hepatic failure (HP:0100626)3.15694970
31Myokymia (HP:0002411)3.15630468
32Lipid accumulation in hepatocytes (HP:0006561)3.09386207
33Genetic anticipation (HP:0003743)3.08064228
34Renal cortical cysts (HP:0000803)3.06393834
35Optic disc pallor (HP:0000543)3.01142065
36Leukodystrophy (HP:0002415)3.00908400
37Hypothermia (HP:0002045)3.00903366
38Pheochromocytoma (HP:0002666)2.98860857
39Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.96873138
40Increased CSF lactate (HP:0002490)2.95332214
41Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.92704384
42Focal seizures (HP:0007359)2.85159456
43Cerebral hemorrhage (HP:0001342)2.82739713
44Progressive cerebellar ataxia (HP:0002073)2.82712958
45Abnormal ciliary motility (HP:0012262)2.82198808
46Fair hair (HP:0002286)2.79089518
47Neuroendocrine neoplasm (HP:0100634)2.74005126
48Stomatitis (HP:0010280)2.73490753
49Hepatocellular necrosis (HP:0001404)2.71097922
50Protruding tongue (HP:0010808)2.70901196
51Absent/shortened dynein arms (HP:0200106)2.70846944
52Dynein arm defect of respiratory motile cilia (HP:0012255)2.70846944
53Volvulus (HP:0002580)2.67715700
54Retinal dysplasia (HP:0007973)2.60513491
55Abnormal pupillary function (HP:0007686)2.54869513
56Broad-based gait (HP:0002136)2.53711337
57Attenuation of retinal blood vessels (HP:0007843)2.50073209
58Vaginal atresia (HP:0000148)2.48607192
59Tubular atrophy (HP:0000092)2.48560052
60Stomach cancer (HP:0012126)2.46702555
61Genital tract atresia (HP:0001827)2.46276378
62Abnormal respiratory epithelium morphology (HP:0012253)2.44891813
63Abnormal respiratory motile cilium morphology (HP:0005938)2.44891813
64Hematochezia (HP:0002573)2.44856310
65Congenital stationary night blindness (HP:0007642)2.44476159
66Abnormal drinking behavior (HP:0030082)2.44277092
67Polydipsia (HP:0001959)2.44277092
68Cystic liver disease (HP:0006706)2.41896383
69Abnormality of renal resorption (HP:0011038)2.38324896
70Bile duct proliferation (HP:0001408)2.36291016
71Abnormal biliary tract physiology (HP:0012439)2.36291016
72Abolished electroretinogram (ERG) (HP:0000550)2.35200582
73Decreased circulating renin level (HP:0003351)2.33929567
74Abnormal respiratory motile cilium physiology (HP:0012261)2.32972779
75Abnormality of the parathyroid morphology (HP:0011766)2.32733916
76Dialeptic seizures (HP:0011146)2.31978442
77Dysmetria (HP:0001310)2.31033020
78Large for gestational age (HP:0001520)2.29271081
793-Methylglutaconic aciduria (HP:0003535)2.27459259
80Absence seizures (HP:0002121)2.27122123
81Epileptic encephalopathy (HP:0200134)2.27096647
82Hyperventilation (HP:0002883)2.26551720
83Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.26307050
84Gait imbalance (HP:0002141)2.25523507
85T lymphocytopenia (HP:0005403)2.25317327
86Cerebral edema (HP:0002181)2.23035084
87Medial flaring of the eyebrow (HP:0010747)2.22463575
88Increased intramyocellular lipid droplets (HP:0012240)2.22299794
89Generalized hypopigmentation of hair (HP:0011358)2.22003007
90Abnormality of T cell number (HP:0011839)2.21951908
91Febrile seizures (HP:0002373)2.21441408
92Termporal pattern (HP:0011008)2.16163653
93Insidious onset (HP:0003587)2.16163653
94Congenital hepatic fibrosis (HP:0002612)2.15315788
95Intestinal atresia (HP:0011100)2.14997315
96Congenital ichthyosiform erythroderma (HP:0007431)2.12844621
97Furrowed tongue (HP:0000221)2.12595799
98Visual hallucinations (HP:0002367)2.10903365
99Progressive inability to walk (HP:0002505)2.07936945
100Exertional dyspnea (HP:0002875)2.07644130
101Spastic gait (HP:0002064)2.06569556
102Aplasia/Hypoplasia of the tibia (HP:0005772)2.05790410
103Abnormality of glycolysis (HP:0004366)2.03478342
104Increased serum pyruvate (HP:0003542)2.03478342
105Ketoacidosis (HP:0001993)2.03167845
106Hypochromic microcytic anemia (HP:0004840)2.02990844
107Respiratory failure (HP:0002878)2.02059691
108Infantile muscular hypotonia (HP:0008947)2.01775698
109Generalized tonic-clonic seizures (HP:0002069)2.01344650
110Congenital primary aphakia (HP:0007707)2.00603613
111Scanning speech (HP:0002168)2.00449677
112Anxiety (HP:0000739)2.00297804
113Supranuclear gaze palsy (HP:0000605)2.00287679
114Exercise intolerance (HP:0003546)2.00018018
115Alacrima (HP:0000522)1.98413129
116Cupped ear (HP:0000378)1.95715997
117Poor coordination (HP:0002370)1.95514302
118Overfolded helix (HP:0000396)1.94870031
119Abnormal hair whorl (HP:0010721)1.93683574
120Tubulointerstitial nephritis (HP:0001970)1.92571852
121Esotropia (HP:0000565)1.91084574
122X-linked dominant inheritance (HP:0001423)1.90899989
123Anomalous pulmonary venous return (HP:0010772)1.90575859
124Abnormal rod and cone electroretinograms (HP:0008323)1.88653521
125Aplasia/Hypoplasia of the tongue (HP:0010295)1.87982757
126Polyphagia (HP:0002591)1.87924066
127Hemiparesis (HP:0001269)1.87464063
128Optic neuritis (HP:0100653)1.87342109
129Retrobulbar optic neuritis (HP:0100654)1.87342109
130Akinesia (HP:0002304)1.85528248
131Male pseudohermaphroditism (HP:0000037)1.83557452
132Rimmed vacuoles (HP:0003805)1.83229346
133Tubulointerstitial abnormality (HP:0001969)1.82191405
134Recurrent cutaneous fungal infections (HP:0011370)1.81693322
135Chronic mucocutaneous candidiasis (HP:0002728)1.81693322
136Abnormality of secondary sexual hair (HP:0009888)1.79767904
137Abnormality of the axillary hair (HP:0100134)1.79767904
138Postaxial foot polydactyly (HP:0001830)1.79735145
139Absent speech (HP:0001344)1.77869584
140Abnormal delayed hypersensitivity skin test (HP:0002963)1.77727535
141Polyuria (HP:0000103)1.77635982
142Hypoplastic iliac wings (HP:0002866)1.77404398
143Papillary thyroid carcinoma (HP:0002895)1.76700073
144Nephrogenic diabetes insipidus (HP:0009806)1.76273951
145Inability to walk (HP:0002540)1.74867225
146Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.73769575
147Morphological abnormality of the pyramidal tract (HP:0002062)1.73520579
148Tented upper lip vermilion (HP:0010804)1.73434609
149Chin dimple (HP:0010751)1.72290285
150Widely spaced teeth (HP:0000687)1.72007633
151Neoplasm of the tracheobronchial system (HP:0100552)1.71752601
152Excessive salivation (HP:0003781)1.71468771
153Drooling (HP:0002307)1.71468771
154Respiratory difficulties (HP:0002880)1.71121688
155Truncal obesity (HP:0001956)1.69732903
156Hepatic necrosis (HP:0002605)1.69123224
157Clumsiness (HP:0002312)1.68853394
158Hyperkalemia (HP:0002153)1.68826520
159Congenital sensorineural hearing impairment (HP:0008527)1.68771919
160Muscle hypertrophy of the lower extremities (HP:0008968)1.68108462
161Onion bulb formation (HP:0003383)1.67977238
162Abnormality of the pulmonary veins (HP:0011718)1.67772133
163Ketosis (HP:0001946)1.67106352
164Calf muscle hypertrophy (HP:0008981)1.66917718
165Facial diplegia (HP:0001349)1.65502983
166Neoplasm of the adrenal cortex (HP:0100641)1.65017216
167Severe combined immunodeficiency (HP:0004430)1.63446976
168Hypoproteinemia (HP:0003075)1.62227915
169Portal hypertension (HP:0001409)1.61365848
170Abnormality of vitamin B metabolism (HP:0004340)1.61267355
171Methylmalonic acidemia (HP:0002912)1.61197153
172Constricted visual fields (HP:0001133)1.60079849
173Hemiplegia (HP:0002301)1.58319293
174Blue irides (HP:0000635)1.58288766
175Chronic diarrhea (HP:0002028)1.58143311
176Hypoplastic ischia (HP:0003175)1.56816165
177Abnormal biliary tract morphology (HP:0012440)1.56555769

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.97529743
2PNCK4.15670472
3STK394.05639001
4ACVR1B3.18420478
5TNIK3.17774773
6CASK3.07072915
7MAP3K122.64382982
8OXSR12.63171790
9EPHA42.61406506
10TAOK32.57194780
11MAPKAPK52.44290086
12FES2.31040221
13AKT32.28077436
14MAP4K22.18110169
15MARK12.00421162
16NTRK31.92899198
17MAP3K41.89705886
18CSNK1G31.87814378
19GRK51.81901079
20NLK1.79299802
21NUAK11.77382366
22WNK41.77183024
23NME11.75027150
24BCR1.74614298
25TXK1.68009785
26PKN11.66539827
27FGR1.61587807
28MAP2K71.59155359
29MST41.57726776
30NTRK11.57174052
31TEC1.49552854
32CSNK1G21.49428235
33MAPK131.48693012
34TYRO31.47727374
35RIPK41.44980596
36GRK71.44547002
37CAMK2B1.43400644
38CSNK1G11.42465128
39SGK21.41877248
40UHMK11.40374750
41ERBB31.34805862
42OBSCN1.31860883
43MKNK21.28827660
44PBK1.27314588
45CAMK2D1.23295577
46PINK11.23064242
47CAMK2A1.21016756
48PIK3CG1.19730443
49BMPR1B1.19406398
50CAMKK21.17652531
51BMPR21.17142297
52ADRBK21.16582858
53CDK191.14805547
54LIMK11.13968891
55INSRR1.13699827
56CSNK1A1L1.11989702
57TRIM281.10605606
58NTRK21.10330607
59STK38L1.10318593
60MAP2K41.10209474
61FGFR31.09980245
62KIT1.07938197
63ARAF1.06739560
64MUSK1.04863380
65ROCK21.04113226
66DAPK21.02346424
67TRPM71.02052844
68IKBKE0.99797034
69EPHB10.99779220
70WNK10.98560274
71PLK20.97953826
72PIK3CA0.97281614
73ITK0.95033052
74EPHA30.92881242
75TNK20.92677358
76MAP2K60.90057034
77CDK50.89915570
78NEK60.89385833
79BLK0.87397776
80IRAK20.86921964
81JAK10.86580217
82FER0.85598892
83MINK10.85578237
84TGFBR10.83772498
85MAPK150.82970972
86MAP3K90.80724974
87PTK2B0.78901547
88CDK140.77447279
89SYK0.76993668
90MAP3K70.73012365
91PRKCE0.71603705
92ADRBK10.70538947
93STK30.70487834
94CAMK1G0.70391178
95DYRK20.69633880
96PRKCQ0.69406539
97STK160.68391024
98CAMK2G0.67921574
99FGFR20.67794106
100PRKAA20.67742576
101SGK30.67306934
102CDK150.66988651
103TYK20.64931453
104CDK180.64773442
105BRSK20.64096908
106BTK0.63211723
107EIF2AK30.62535333
108CDK11A0.60101111
109IRAK10.59052656
110MET0.58673285
111PRKACA0.56776779
112TLK10.56034238
113DYRK1A0.55872789
114STK110.55515845
115LCK0.53556458
116WNK30.53407538
117VRK10.52574380
118FYN0.51537334
119PRKCG0.50886515
120LYN0.50478824
121MAP3K20.49038846
122LATS10.48850095
123IKBKB0.48631861
124CSNK1E0.48076349
125ERBB40.47977864
126HCK0.47826401
127ZAK0.47504373
128MKNK10.46237240
129ERBB20.45039861
130JAK30.44922931
131MAP4K10.44338869
132PRKG10.43755298
133PAK30.42403574
134CHUK0.42370264
135RPS6KA50.42350642
136YES10.41846817
137RET0.41600281
138CSNK1A10.40540197
139PHKG10.40198126
140PHKG20.40198126
141MARK20.40064995
142CAMK40.39699971
143EGFR0.38860190
144MAP3K130.38791623
145MARK30.38484326
146CLK10.37849730
147GRK10.37576338
148PRKAA10.35163752
149GRK60.34816980
150SIK20.34323740
151ABL20.34160831
152SGK10.34064967
153CAMK10.33697129
154MYLK0.33066592
155BRD40.32873589
156MAP3K60.32869273
157CDK30.32758445
158SGK2230.32656170
159SGK4940.32656170
160PRKD20.32300037

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.81333546
2Parkinsons disease_Homo sapiens_hsa050123.90856917
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.44380665
4Alzheimers disease_Homo sapiens_hsa050103.30989597
5Nicotine addiction_Homo sapiens_hsa050333.00602707
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.69729131
7Huntingtons disease_Homo sapiens_hsa050162.65224146
8Collecting duct acid secretion_Homo sapiens_hsa049662.42124372
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.27788620
10Steroid biosynthesis_Homo sapiens_hsa001002.26165525
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.23526553
12Serotonergic synapse_Homo sapiens_hsa047262.12930566
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.11077102
14Fatty acid elongation_Homo sapiens_hsa000622.07791591
15Cardiac muscle contraction_Homo sapiens_hsa042602.00331364
16ABC transporters_Homo sapiens_hsa020101.95087340
17Protein export_Homo sapiens_hsa030601.90591295
18Glutamatergic synapse_Homo sapiens_hsa047241.83548280
19Circadian rhythm_Homo sapiens_hsa047101.82603932
20Ether lipid metabolism_Homo sapiens_hsa005651.81101580
21Nitrogen metabolism_Homo sapiens_hsa009101.80406307
22Synaptic vesicle cycle_Homo sapiens_hsa047211.77665480
23GABAergic synapse_Homo sapiens_hsa047271.75947712
24Regulation of autophagy_Homo sapiens_hsa041401.73783265
25Amphetamine addiction_Homo sapiens_hsa050311.72610337
26Cocaine addiction_Homo sapiens_hsa050301.64168218
27Long-term depression_Homo sapiens_hsa047301.64072429
28Type I diabetes mellitus_Homo sapiens_hsa049401.62738903
29Morphine addiction_Homo sapiens_hsa050321.58445015
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.56884463
31Taste transduction_Homo sapiens_hsa047421.56132534
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.54640713
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.53677550
34Propanoate metabolism_Homo sapiens_hsa006401.51748381
35Dopaminergic synapse_Homo sapiens_hsa047281.51536249
36Sulfur metabolism_Homo sapiens_hsa009201.49443788
37Axon guidance_Homo sapiens_hsa043601.47682353
38Long-term potentiation_Homo sapiens_hsa047201.43973275
39Vibrio cholerae infection_Homo sapiens_hsa051101.43121749
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42222534
41Ribosome_Homo sapiens_hsa030101.41388678
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.39439535
43Circadian entrainment_Homo sapiens_hsa047131.36830293
44Phototransduction_Homo sapiens_hsa047441.33190444
45Intestinal immune network for IgA production_Homo sapiens_hsa046721.30318759
46Primary immunodeficiency_Homo sapiens_hsa053401.25220132
47Renin secretion_Homo sapiens_hsa049241.22835465
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.21050294
49Salivary secretion_Homo sapiens_hsa049701.20543856
50Cholinergic synapse_Homo sapiens_hsa047251.20398386
51Tryptophan metabolism_Homo sapiens_hsa003801.15028456
52Graft-versus-host disease_Homo sapiens_hsa053321.13197862
53Peroxisome_Homo sapiens_hsa041461.10881140
54Rheumatoid arthritis_Homo sapiens_hsa053231.10082602
55Asthma_Homo sapiens_hsa053101.09423055
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06895101
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.06574596
58Primary bile acid biosynthesis_Homo sapiens_hsa001201.05268944
59Allograft rejection_Homo sapiens_hsa053301.04708688
60Jak-STAT signaling pathway_Homo sapiens_hsa046301.04243659
61Caffeine metabolism_Homo sapiens_hsa002320.99259324
62Calcium signaling pathway_Homo sapiens_hsa040200.98309959
63Sphingolipid metabolism_Homo sapiens_hsa006000.97980093
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95452313
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91901549
66Gastric acid secretion_Homo sapiens_hsa049710.90730911
67Fanconi anemia pathway_Homo sapiens_hsa034600.89993300
68Butanoate metabolism_Homo sapiens_hsa006500.89310613
69NOD-like receptor signaling pathway_Homo sapiens_hsa046210.89148516
70RNA polymerase_Homo sapiens_hsa030200.87921650
71Platelet activation_Homo sapiens_hsa046110.87864214
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.87758415
73Basal transcription factors_Homo sapiens_hsa030220.87706107
74T cell receptor signaling pathway_Homo sapiens_hsa046600.83738412
75Linoleic acid metabolism_Homo sapiens_hsa005910.83015568
76Gap junction_Homo sapiens_hsa045400.78403374
77Chemical carcinogenesis_Homo sapiens_hsa052040.77484589
78Retinol metabolism_Homo sapiens_hsa008300.76498475
79Non-homologous end-joining_Homo sapiens_hsa034500.76367052
80Type II diabetes mellitus_Homo sapiens_hsa049300.76237689
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.75683984
82Inositol phosphate metabolism_Homo sapiens_hsa005620.75548449
83Hematopoietic cell lineage_Homo sapiens_hsa046400.75383616
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74980622
85Tyrosine metabolism_Homo sapiens_hsa003500.74359617
86African trypanosomiasis_Homo sapiens_hsa051430.73762803
87RNA degradation_Homo sapiens_hsa030180.73722869
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73307458
89Oxytocin signaling pathway_Homo sapiens_hsa049210.73041421
90Insulin secretion_Homo sapiens_hsa049110.71944937
91Staphylococcus aureus infection_Homo sapiens_hsa051500.71747363
92FoxO signaling pathway_Homo sapiens_hsa040680.71002505
93Glycerolipid metabolism_Homo sapiens_hsa005610.70739719
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70555640
95Proteasome_Homo sapiens_hsa030500.69755389
96Olfactory transduction_Homo sapiens_hsa047400.68583495
97Alcoholism_Homo sapiens_hsa050340.66625848
98GnRH signaling pathway_Homo sapiens_hsa049120.66600902
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66015585
100Lysine degradation_Homo sapiens_hsa003100.65999068
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64756858
102Selenocompound metabolism_Homo sapiens_hsa004500.64258667
103Fatty acid biosynthesis_Homo sapiens_hsa000610.62997265
104Dorso-ventral axis formation_Homo sapiens_hsa043200.61142111
105Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.60292382
106Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59805575
107Histidine metabolism_Homo sapiens_hsa003400.59244398
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58698566
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57921724
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57805995
111Pancreatic secretion_Homo sapiens_hsa049720.56298825
112RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53590031
113Measles_Homo sapiens_hsa051620.51996373
114Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51843401
115Leishmaniasis_Homo sapiens_hsa051400.51118153
116Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50724378
117Melanogenesis_Homo sapiens_hsa049160.50064108
118Fatty acid degradation_Homo sapiens_hsa000710.48940421
119NF-kappa B signaling pathway_Homo sapiens_hsa040640.48118456
120Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45577284
121Metabolic pathways_Homo sapiens_hsa011000.44982859
122Prion diseases_Homo sapiens_hsa050200.44467206
123Autoimmune thyroid disease_Homo sapiens_hsa053200.43390475
124Arachidonic acid metabolism_Homo sapiens_hsa005900.43056315
125Phagosome_Homo sapiens_hsa041450.43032718
126SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41380467
127Vitamin B6 metabolism_Homo sapiens_hsa007500.41340954
128Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.41315596
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.40351444
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.40242375
131Renal cell carcinoma_Homo sapiens_hsa052110.39266026
132Phenylalanine metabolism_Homo sapiens_hsa003600.39104032
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.38895289
134Ras signaling pathway_Homo sapiens_hsa040140.38688593
135cAMP signaling pathway_Homo sapiens_hsa040240.38308275
136Ovarian steroidogenesis_Homo sapiens_hsa049130.36075601
137Choline metabolism in cancer_Homo sapiens_hsa052310.35107188
138Thyroid hormone synthesis_Homo sapiens_hsa049180.34999468
139Estrogen signaling pathway_Homo sapiens_hsa049150.32227774
140Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30566698
141Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30035897
142Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29007570
143cGMP-PKG signaling pathway_Homo sapiens_hsa040220.24371737
144Wnt signaling pathway_Homo sapiens_hsa043100.24150865
145ErbB signaling pathway_Homo sapiens_hsa040120.23086329
146Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22453172
147MAPK signaling pathway_Homo sapiens_hsa040100.20263183
148Mineral absorption_Homo sapiens_hsa049780.20204693
149Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.20019803
150Hedgehog signaling pathway_Homo sapiens_hsa043400.19195618
151Arginine and proline metabolism_Homo sapiens_hsa003300.15612745

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