N4BP2L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of amino acid transport (GO:0051956)6.77275852
2positive regulation of amino acid transport (GO:0051957)6.24232512
3phospholipid scrambling (GO:0017121)5.92861231
4negative regulation of neurotransmitter secretion (GO:0046929)5.82084730
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.72158272
6L-phenylalanine catabolic process (GO:0006559)5.72158272
7regulation of glutamate secretion (GO:0014048)5.48057513
8L-phenylalanine metabolic process (GO:0006558)5.47496943
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.47496943
10mannose metabolic process (GO:0006013)5.28743967
11aromatic amino acid family catabolic process (GO:0009074)5.27745400
12positive regulation of catecholamine secretion (GO:0033605)5.00091510
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.93313666
14tryptophan catabolic process (GO:0006569)4.88396099
15indole-containing compound catabolic process (GO:0042436)4.88396099
16indolalkylamine catabolic process (GO:0046218)4.88396099
17tryptophan metabolic process (GO:0006568)4.55916239
18high-density lipoprotein particle remodeling (GO:0034375)4.53675209
19kynurenine metabolic process (GO:0070189)4.52267225
20mature B cell differentiation involved in immune response (GO:0002313)4.50005807
21urea metabolic process (GO:0019627)4.42446237
22urea cycle (GO:0000050)4.42446237
23regulation of cholesterol esterification (GO:0010872)4.39353580
24bile acid biosynthetic process (GO:0006699)4.34346079
25phospholipid efflux (GO:0033700)4.31650981
26neutrophil activation involved in immune response (GO:0002283)4.21360812
27antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.17409308
28nitrogen cycle metabolic process (GO:0071941)4.12825751
29regulation of T-helper 1 cell differentiation (GO:0045625)4.11410121
30imidazole-containing compound metabolic process (GO:0052803)4.07599210
31negative regulation of neurotransmitter transport (GO:0051589)4.07223166
32alpha-linolenic acid metabolic process (GO:0036109)4.03007699
33antigen processing and presentation of endogenous antigen (GO:0019883)4.00643128
34complement activation, alternative pathway (GO:0006957)3.98712642
35fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.97817176
36peptidyl-glutamic acid carboxylation (GO:0017187)3.95278308
37protein carboxylation (GO:0018214)3.95278308
38mucosal-associated lymphoid tissue development (GO:0048537)3.94190314
39Peyers patch development (GO:0048541)3.94190314
40immunoglobulin mediated immune response (GO:0016064)3.93800681
41reverse cholesterol transport (GO:0043691)3.92459495
42protein-lipid complex remodeling (GO:0034368)3.88568016
43macromolecular complex remodeling (GO:0034367)3.88568016
44plasma lipoprotein particle remodeling (GO:0034369)3.88568016
45regulation of triglyceride catabolic process (GO:0010896)3.87262385
46regulation of fibrinolysis (GO:0051917)3.77993295
47negative regulation of fibrinolysis (GO:0051918)3.77502227
48low-density lipoprotein particle remodeling (GO:0034374)3.76268873
49aromatic amino acid family metabolic process (GO:0009072)3.74764060
50bile acid metabolic process (GO:0008206)3.74142664
51cholesterol efflux (GO:0033344)3.71768019
52cysteine metabolic process (GO:0006534)3.70219934
53glyoxylate metabolic process (GO:0046487)3.69457175
54antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.68222040
55antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.68222040
56mature B cell differentiation (GO:0002335)3.67966653
57regulation of protein activation cascade (GO:2000257)3.63000506
58response to peptidoglycan (GO:0032494)3.59886081
59negative regulation of cholesterol transport (GO:0032375)3.56830228
60negative regulation of sterol transport (GO:0032372)3.56830228
61negative regulation of interleukin-12 production (GO:0032695)3.55134488
62regulation of amino acid transport (GO:0051955)3.51311756
63positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.50184424
64sulfur amino acid catabolic process (GO:0000098)3.49221064
65tyrosine metabolic process (GO:0006570)3.48249458
66amine catabolic process (GO:0009310)3.47369391
67cellular biogenic amine catabolic process (GO:0042402)3.47369391
68interferon-gamma-mediated signaling pathway (GO:0060333)3.45141942
69indolalkylamine metabolic process (GO:0006586)3.43172473
70serine family amino acid catabolic process (GO:0009071)3.42267214
71regulation of B cell receptor signaling pathway (GO:0050855)3.42018214
72triglyceride homeostasis (GO:0070328)3.41691180
73acylglycerol homeostasis (GO:0055090)3.41691180
74NAD biosynthetic process (GO:0009435)3.38850179
75alpha-amino acid catabolic process (GO:1901606)3.37209680
76regulation of complement activation (GO:0030449)3.36913079
77negative regulation of cell killing (GO:0031342)3.36168194
78negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.36168194
79plasma lipoprotein particle clearance (GO:0034381)3.35917690
80serotonin receptor signaling pathway (GO:0007210)3.35204619
81NIK/NF-kappaB signaling (GO:0038061)3.34367281
82plasma lipoprotein particle assembly (GO:0034377)3.28812035
83response to type I interferon (GO:0034340)3.28415015
84type I interferon signaling pathway (GO:0060337)3.27191774
85cellular response to type I interferon (GO:0071357)3.27191774
86positive regulation of granulocyte differentiation (GO:0030854)3.26753834
87regulation of interferon-alpha production (GO:0032647)3.22898477
88amino-acid betaine metabolic process (GO:0006577)3.21325070
89negative regulation of organic acid transport (GO:0032891)3.19633273
90phospholipid homeostasis (GO:0055091)3.19235594
91pyridine nucleotide biosynthetic process (GO:0019363)3.18098490
92nicotinamide nucleotide biosynthetic process (GO:0019359)3.18098490
93bile acid and bile salt transport (GO:0015721)3.17831361
94valine metabolic process (GO:0006573)3.17526303
95drug catabolic process (GO:0042737)3.17034411
96negative regulation of erythrocyte differentiation (GO:0045647)3.16564357
97defense response to protozoan (GO:0042832)3.15766213
98positive regulation of organic acid transport (GO:0032892)3.15606217
99regulation of chronic inflammatory response (GO:0002676)3.15039665
100coenzyme catabolic process (GO:0009109)3.13288112
101glutamate metabolic process (GO:0006536)3.11373549
102benzene-containing compound metabolic process (GO:0042537)3.11206181
103plasma lipoprotein particle organization (GO:0071827)3.10206716
104dicarboxylic acid biosynthetic process (GO:0043650)3.09973997
105cofactor catabolic process (GO:0051187)3.07077424
106killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.07001113
107disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.07001113
108positive regulation of lipid catabolic process (GO:0050996)3.05669863
109regulation of gamma-delta T cell activation (GO:0046643)3.03790267
110negative regulation of lipase activity (GO:0060192)3.03321433
111response to protozoan (GO:0001562)3.03195366
112cellular amino acid catabolic process (GO:0009063)3.03110149
113positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.03087464
114complement activation, classical pathway (GO:0006958)3.02677000
115homocysteine metabolic process (GO:0050667)3.01008218
116blood coagulation, intrinsic pathway (GO:0007597)2.99286729
117opsonization (GO:0008228)2.99016175
118B cell mediated immunity (GO:0019724)2.97531000
119protein activation cascade (GO:0072376)2.97205599
120regulation of antigen processing and presentation (GO:0002577)2.97071665
121complement activation (GO:0006956)2.96953998
122very-low-density lipoprotein particle assembly (GO:0034379)2.93129700
123granulocyte activation (GO:0036230)2.93006223
124protein-lipid complex assembly (GO:0065005)2.92702296
125neutrophil activation (GO:0042119)2.92566231
126T cell migration (GO:0072678)2.91717479
127positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.91465935
128regulation of germinal center formation (GO:0002634)2.90952537
129arginine metabolic process (GO:0006525)2.90947152
130protein-lipid complex subunit organization (GO:0071825)2.90440114
131N-glycan processing (GO:0006491)2.90353191
132positive thymic T cell selection (GO:0045059)2.89176335
133cellular ketone body metabolic process (GO:0046950)2.88723612
134lysine metabolic process (GO:0006553)2.88684563
135lysine catabolic process (GO:0006554)2.88684563
136positive regulation of gamma-delta T cell activation (GO:0046645)2.86878351
137positive regulation of antigen processing and presentation (GO:0002579)2.86634526
138regulation of T-helper cell differentiation (GO:0045622)2.86068931
139positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.85581307
140cellular modified amino acid catabolic process (GO:0042219)2.85429134
141positive regulation of interferon-alpha production (GO:0032727)2.85211480
142acute-phase response (GO:0006953)2.84654250
143negative regulation of amine transport (GO:0051953)2.84337717
144regulation of dendritic cell antigen processing and presentation (GO:0002604)2.84167766
145ethanol oxidation (GO:0006069)2.84167112
146positive regulation of humoral immune response (GO:0002922)2.82572467
147cholesterol homeostasis (GO:0042632)2.81606979
148regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.81552983
149regulation of membrane lipid distribution (GO:0097035)2.81205043
150macrophage activation involved in immune response (GO:0002281)2.80830746
151myeloid cell activation involved in immune response (GO:0002275)2.80747556
152aldehyde catabolic process (GO:0046185)2.79666603
153positive regulation of type 2 immune response (GO:0002830)2.79419494
154short-chain fatty acid metabolic process (GO:0046459)2.79037950
155lipopolysaccharide-mediated signaling pathway (GO:0031663)2.78994914
156positive regulation of T-helper cell differentiation (GO:0045624)2.78304121
157regulation of humoral immune response (GO:0002920)2.77637876
158cellular glucuronidation (GO:0052695)2.76776303
159detection of other organism (GO:0098543)2.76542977
160positive regulation of B cell differentiation (GO:0045579)2.76038790
161negative regulation of cytokine production involved in immune response (GO:0002719)2.73851930
162positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.73226555
163detection of bacterium (GO:0016045)2.72037214
164regulation of chemokine biosynthetic process (GO:0045073)2.71797796
165regulation of vitamin D biosynthetic process (GO:0060556)2.70923067
166regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.68965540
167regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.67873032
168positive regulation of interleukin-17 production (GO:0032740)2.67465892
169positive regulation of defense response to virus by host (GO:0002230)2.65257891
170regulation of alpha-beta T cell proliferation (GO:0046640)2.63509628
171regulation of T cell tolerance induction (GO:0002664)2.63260925
172response to muramyl dipeptide (GO:0032495)2.62619662
173modulation of growth of symbiont involved in interaction with host (GO:0044144)2.61841586
174regulation of growth of symbiont in host (GO:0044126)2.61841586
175negative regulation of growth of symbiont in host (GO:0044130)2.61841586
176negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.61841586
177CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.61373624
178regulation of mast cell degranulation (GO:0043304)2.61135077
179cellular response to interferon-gamma (GO:0071346)2.60931133
180negative regulation of T cell mediated immunity (GO:0002710)2.58444107
181positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.58121821
182positive regulation of alpha-beta T cell proliferation (GO:0046641)2.57730401
183germinal center formation (GO:0002467)2.56796730
184negative thymic T cell selection (GO:0045060)2.55189660
185positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.54961259
186regulation of gamma-delta T cell differentiation (GO:0045586)2.54947718
187regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.54251432
188regulation of tolerance induction (GO:0002643)2.53159498
189T-helper 1 type immune response (GO:0042088)2.52583482
190regulation of interleukin-12 production (GO:0032655)2.51547001
191regulation of mast cell activation (GO:0033003)2.50534253
192positive regulation of interferon-beta production (GO:0032728)2.49388071
193cellular response to exogenous dsRNA (GO:0071360)2.49035210
194negative T cell selection (GO:0043383)2.46195763

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.88090204
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.71585631
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.95123998
4EGR1_23403033_ChIP-Seq_LIVER_Mouse4.93261304
5IRF8_22096565_ChIP-ChIP_GC-B_Human4.85666646
6* LXR_22158963_ChIP-Seq_LIVER_Mouse4.46573424
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.72926643
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.59160519
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.51996646
10IRF8_21731497_ChIP-ChIP_J774_Mouse3.17753918
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.13132099
12GATA1_22025678_ChIP-Seq_K562_Human3.12539057
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.91258902
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.90180004
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.42207890
16* IRF8_27001747_Chip-Seq_BMDM_Mouse2.31937371
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.28978018
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.19035353
19* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.17144308
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.12214576
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.03201811
22* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.94289274
23* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.87944095
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.83392487
25CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.75773973
26RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.73716485
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.67524274
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.66491965
29RUNX_20019798_ChIP-Seq_JUKART_Human1.63474800
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.63172491
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.62920862
32TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.57700221
33SCL_19346495_ChIP-Seq_HPC-7_Human1.49756751
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.49227958
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.49014349
36IGF1R_20145208_ChIP-Seq_DFB_Human1.46839834
37LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.42713417
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.41785436
39BP1_19119308_ChIP-ChIP_Hs578T_Human1.37136991
40* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.32135698
41GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28679492
42TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27403366
43* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.22305310
44* GATA1_19941827_ChIP-Seq_MEL_Mouse1.21166424
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.18923509
46E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18231098
47GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.17760450
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12055327
49EGR1_19032775_ChIP-ChIP_M12_Human1.11325116
50STAT1_20625510_ChIP-Seq_HELA_Human1.08888377
51MYB_26560356_Chip-Seq_TH2_Human1.08564383
52VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07636466
53FOXA2_19822575_ChIP-Seq_HepG2_Human1.06362703
54HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.03030499
55MAF_26560356_Chip-Seq_TH1_Human1.03000440
56VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00458477
57MYB_26560356_Chip-Seq_TH1_Human1.00218058
58HTT_18923047_ChIP-ChIP_STHdh_Human0.99148212
59PRDM14_20953172_ChIP-Seq_ESCs_Human0.97409865
60VDR_24787735_ChIP-Seq_THP-1_Human0.97141367
61* GATA3_26560356_Chip-Seq_TH2_Human0.95065253
62CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94405885
63NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.92952739
64PU_27001747_Chip-Seq_BMDM_Mouse0.92234226
65MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.91429516
66UTX_26944678_Chip-Seq_JUKART_Human0.90434214
67STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.89373841
68PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88987389
69CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87736723
70NOTCH1_21737748_ChIP-Seq_TLL_Human0.87664017
71FLI1_27457419_Chip-Seq_LIVER_Mouse0.87642924
72VDR_24763502_ChIP-Seq_THP-1_Human0.87003913
73TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.86993155
74GATA1_19941826_ChIP-Seq_K562_Human0.86044104
75GATA3_27048872_Chip-Seq_THYMUS_Human0.85495532
76PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85442036
77GATA2_19941826_ChIP-Seq_K562_Human0.85221884
78GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.84311625
79CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82449017
80SMRT_27268052_Chip-Seq_Bcells_Human0.81754778
81RUNX1_22412390_ChIP-Seq_EML_Mouse0.81615005
82SPI1_23547873_ChIP-Seq_NB4_Human0.80924204
83HNF4A_19822575_ChIP-Seq_HepG2_Human0.79958380
84GATA1_19941827_ChIP-Seq_MEL86_Mouse0.79813271
85CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79570681
86* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.78913054
87RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.78531658
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.78292763
89SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77926322
90PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77798206
91GATA2_22383799_ChIP-Seq_G1ME_Mouse0.77719422
92FOXA1_21572438_ChIP-Seq_LNCaP_Human0.76360303
93GATA2_21666600_ChIP-Seq_HMVEC_Human0.75236797
94GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73270984
95BCL6_27268052_Chip-Seq_Bcells_Human0.73107680
96VDR_21846776_ChIP-Seq_THP-1_Human0.73068388
97RXRA_24833708_ChIP-Seq_LIVER_Mouse0.72131682
98SMAD1_18555785_Chip-Seq_ESCs_Mouse0.71994537
99NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.71713083
100NRF2_20460467_ChIP-Seq_MEFs_Mouse0.71713083
101FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.71316834
102EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.71239849
103BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.71227305
104GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.71018234
105CDX2_19796622_ChIP-Seq_MESCs_Mouse0.70509864
106KDM2B_26808549_Chip-Seq_SUP-B15_Human0.69982304
107JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.69505513
108RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.69377544
109TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.69328081
110VDR_22108803_ChIP-Seq_LS180_Human0.69285252
111SPI1_23127762_ChIP-Seq_K562_Human0.67928124
112BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.67489375
113GATA1_22383799_ChIP-Seq_G1ME_Mouse0.67316654
114PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.65595770
115PU.1_20513432_ChIP-Seq_Bcells_Mouse0.63529999
116CLOCK_20551151_ChIP-Seq_293T_Human0.62219312
117SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.62189951
118TCF7_22412390_ChIP-Seq_EML_Mouse0.62001232
119FOXA1_25552417_ChIP-Seq_VCAP_Human0.60853381
120CEBPB_22108803_ChIP-Seq_LS180_Human0.60760048
121TAF15_26573619_Chip-Seq_HEK293_Human0.60733405
122EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.60594973
123LXR_22292898_ChIP-Seq_THP-1_Human0.59657129
124NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.59578372
125SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.59511093
126ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.58175214
127* GATA3_26560356_Chip-Seq_TH1_Human0.58112657
128SMAD_19615063_ChIP-ChIP_OVARY_Human0.57979632
129SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.57851844
130MAF_26560356_Chip-Seq_TH2_Human0.57315471
131SOX2_27498859_Chip-Seq_STOMACH_Mouse0.56818178

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.37336815
2MP0005360_urolithiasis4.70749834
3MP0005085_abnormal_gallbladder_physiolo4.30776002
4MP0005365_abnormal_bile_salt4.20808681
5MP0008875_abnormal_xenobiotic_pharmacok3.52298200
6MP0002254_reproductive_system_inflammat3.45446959
7MP0001835_abnormal_antigen_presentation3.11654024
8MP0002138_abnormal_hepatobiliary_system2.85402224
9MP0009840_abnormal_foam_cell2.82611685
10MP0008961_abnormal_basal_metabolism2.78752982
11MP0000685_abnormal_immune_system2.73138227
12MP0010329_abnormal_lipoprotein_level2.56128071
13MP0003252_abnormal_bile_duct2.53326175
14MP0003191_abnormal_cellular_cholesterol2.37189425
15MP0002876_abnormal_thyroid_physiology2.21814927
16MP0009278_abnormal_bone_marrow2.21204705
17MP0003195_calcinosis2.18862899
18MP0002396_abnormal_hematopoietic_system2.04410982
19MP0005397_hematopoietic_system_phenotyp2.01904295
20MP0001545_abnormal_hematopoietic_system2.01904295
21MP0009785_altered_susceptibility_to1.99907659
22MP0005671_abnormal_response_to1.99697619
23MP0001790_abnormal_immune_system1.96094201
24MP0005387_immune_system_phenotype1.96094201
25MP0003806_abnormal_nucleotide_metabolis1.92995327
26MP0005332_abnormal_amino_acid1.89696203
27MP0002822_catalepsy1.88341924
28MP0005083_abnormal_biliary_tract1.87734999
29MP0005167_abnormal_blood-brain_barrier1.85253173
30MP0006082_CNS_inflammation1.84819006
31MP0003436_decreased_susceptibility_to1.83516704
32MP0000609_abnormal_liver_physiology1.82926493
33MP0001666_abnormal_nutrient_absorption1.76479185
34MP0004510_myositis1.70316122
35MP0001800_abnormal_humoral_immune1.65566114
36MP0002118_abnormal_lipid_homeostasis1.62951992
37MP0005025_abnormal_response_to1.62521777
38MP0001764_abnormal_homeostasis1.58978931
39MP0002148_abnormal_hypersensitivity_rea1.58664704
40MP0001873_stomach_inflammation1.57363982
41MP0005000_abnormal_immune_tolerance1.56657890
42MP0004808_abnormal_hematopoietic_stem1.55910041
43MP0002419_abnormal_innate_immunity1.55291074
44MP0005464_abnormal_platelet_physiology1.48777162
45MP0008004_abnormal_stomach_pH1.47255217
46MP0009333_abnormal_splenocyte_physiolog1.46816066
47MP0009764_decreased_sensitivity_to1.46442257
48MP0005310_abnormal_salivary_gland1.45889686
49MP0008469_abnormal_protein_level1.45292579
50MP0003828_pulmonary_edema1.43252978
51MP0002723_abnormal_immune_serum1.42761075
52MP0001853_heart_inflammation1.41133828
53MP0003656_abnormal_erythrocyte_physiolo1.40933341
54MP0003724_increased_susceptibility_to1.40682390
55MP0003868_abnormal_feces_composition1.39541008
56MP0005319_abnormal_enzyme/_coenzyme1.39516299
57MP0005584_abnormal_enzyme/coenzyme_acti1.38301303
58MP0004019_abnormal_vitamin_homeostasis1.34845766
59MP0002452_abnormal_antigen_presenting1.34593518
60MP0001348_abnormal_lacrimal_gland1.28134948
61MP0002166_altered_tumor_susceptibility1.27741405
62MP0000465_gastrointestinal_hemorrhage1.26474248
63MP0001501_abnormal_sleep_pattern1.23373545
64MP0001845_abnormal_inflammatory_respons1.22894062
65MP0001819_abnormal_immune_cell1.21756134
66MP0002420_abnormal_adaptive_immunity1.21099386
67MP0000604_amyloidosis1.20394092
68MP0003763_abnormal_thymus_physiology1.13992145
69MP0002735_abnormal_chemical_nociception1.13375697
70MP0009763_increased_sensitivity_to1.11367222
71MP0003866_abnormal_defecation1.09164766
72MP0006054_spinal_hemorrhage1.09011533
73MP0009643_abnormal_urine_homeostasis1.08208695
74MP0005535_abnormal_body_temperature1.07595288
75MP0004883_abnormal_blood_vessel1.06452973
76MP0003075_altered_response_to1.02825572
77MP0009765_abnormal_xenobiotic_induced1.01696588
78MP0002332_abnormal_exercise_endurance1.00538692
79MP0003172_abnormal_lysosome_physiology0.99488163
80MP0005647_abnormal_sex_gland0.99359558
81MP0000716_abnormal_immune_system0.99204396
82MP0002405_respiratory_system_inflammati0.97507372
83MP0005058_abnormal_lysosome_morphology0.96659696
84MP0005645_abnormal_hypothalamus_physiol0.96492586
85MP0010155_abnormal_intestine_physiology0.94926411
86MP0002971_abnormal_brown_adipose0.94413042
87MP0000920_abnormal_myelination0.94070153
88MP0002998_abnormal_bone_remodeling0.93891484
89MP0003453_abnormal_keratinocyte_physiol0.92707515
90MP0003690_abnormal_glial_cell0.92121338
91MP0004947_skin_inflammation0.89745229
92MP0000598_abnormal_liver_morphology0.89301076
93MP0008874_decreased_physiological_sensi0.88973247
94MP0003186_abnormal_redox_activity0.88470383
95MP0003646_muscle_fatigue0.88436968
96MP0002398_abnormal_bone_marrow0.88037113
97MP0005334_abnormal_fat_pad0.87856714
98MP0000703_abnormal_thymus_morphology0.86580942
99MP0008872_abnormal_physiological_respon0.85637570
100MP0005164_abnormal_response_to0.85439610
101MP0009642_abnormal_blood_homeostasis0.85356563
102MP0003303_peritoneal_inflammation0.85065230
103MP0002078_abnormal_glucose_homeostasis0.84064520
104MP0000343_altered_response_to0.83245284
105MP0002933_joint_inflammation0.80886810
106MP0001346_abnormal_lacrimal_gland0.80295862
107MP0001663_abnormal_digestive_system0.80247316
108MP0003183_abnormal_peptide_metabolism0.79880402
109MP0000689_abnormal_spleen_morphology0.79781212
110MP0005636_abnormal_mineral_homeostasis0.79643216
111MP0005451_abnormal_body_composition0.79469407
112MP0005379_endocrine/exocrine_gland_phen0.79391995
113MP0001851_eye_inflammation0.78889081
114MP0002006_tumorigenesis0.78842526
115MP0002693_abnormal_pancreas_physiology0.76023588
116MP0002429_abnormal_blood_cell0.75671234
117MP0005448_abnormal_energy_balance0.74416676
118MP0004484_altered_response_of0.74357496
119MP0009697_abnormal_copulation0.73886210
120MP0001533_abnormal_skeleton_physiology0.71834487
121MP0004130_abnormal_muscle_cell0.71277874
122MP0002722_abnormal_immune_system0.70854020
123MP0000249_abnormal_blood_vessel0.69284956
124MP0003300_gastrointestinal_ulcer0.68910407
125MP0005670_abnormal_white_adipose0.67585275
126MP0003638_abnormal_response/metabolism_0.67479865
127MP0000858_altered_metastatic_potential0.67290369
128MP0004782_abnormal_surfactant_physiolog0.66554317
129MP0003879_abnormal_hair_cell0.65216488
130MP0000678_abnormal_parathyroid_gland0.62270046
131MP0002136_abnormal_kidney_physiology0.61610168
132MP0005166_decreased_susceptibility_to0.60984108
133MP0003448_altered_tumor_morphology0.58987126
134MP0001986_abnormal_taste_sensitivity0.58861347

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.92907964
2Prolonged partial thromboplastin time (HP:0003645)5.13969602
3Deep venous thrombosis (HP:0002625)4.94078135
4Intrahepatic cholestasis (HP:0001406)4.60756720
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.53485194
6Stomatitis (HP:0010280)4.51531040
7Retrobulbar optic neuritis (HP:0100654)4.50362002
8Optic neuritis (HP:0100653)4.50362002
9Hypobetalipoproteinemia (HP:0003563)4.48566074
10Xanthomatosis (HP:0000991)4.46155209
11Hyperlipoproteinemia (HP:0010980)4.23184365
12Complement deficiency (HP:0004431)4.18344184
13Abnormality of liposaccharide metabolism (HP:0010968)4.04444037
14Abnormality of glycosphingolipid metabolism (HP:0004343)4.04444037
15Abnormality of glycolipid metabolism (HP:0010969)4.04444037
16Joint hemorrhage (HP:0005261)3.95519311
17Abnormality of the common coagulation pathway (HP:0010990)3.61295261
18Recurrent gram-negative bacterial infections (HP:0005420)3.51372263
19Abnormality of glutamine family amino acid metabolism (HP:0010902)3.37630998
20Keratoconjunctivitis sicca (HP:0001097)3.34118973
21Systemic lupus erythematosus (HP:0002725)3.25449800
22Hyperammonemia (HP:0001987)3.23772973
23Hypolipoproteinemia (HP:0010981)3.20858167
24Ketosis (HP:0001946)3.19535018
25Abnormality of complement system (HP:0005339)3.15740932
26Epidermoid cyst (HP:0200040)3.14798543
27Pulmonary infiltrates (HP:0002113)3.13739342
28Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.05338970
29Eczematoid dermatitis (HP:0000976)3.03380977
30Myocardial infarction (HP:0001658)3.02917820
31Encephalitis (HP:0002383)3.01626938
32Gingival bleeding (HP:0000225)2.97253669
33Hypoglycemic coma (HP:0001325)2.94846226
34Conjugated hyperbilirubinemia (HP:0002908)2.93993533
35Recurrent bacterial skin infections (HP:0005406)2.93645211
36Fat malabsorption (HP:0002630)2.93530409
37Prolonged bleeding time (HP:0003010)2.91791417
38Abnormality of the intrinsic pathway (HP:0010989)2.91639098
39Autoimmune hemolytic anemia (HP:0001890)2.90660974
40Gangrene (HP:0100758)2.89960908
41Absent rod-and cone-mediated responses on ERG (HP:0007688)2.87114514
42Dysostosis multiplex (HP:0000943)2.85628453
43Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.83936354
44Short 1st metacarpal (HP:0010034)2.83936354
45Hemoptysis (HP:0002105)2.83454331
46Hyperglycinemia (HP:0002154)2.81335369
47Abnormality of B cell number (HP:0010975)2.79939764
48Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.79435100
49Recurrent skin infections (HP:0001581)2.77876141
50Hypercholesterolemia (HP:0003124)2.76676418
51Hyperglycinuria (HP:0003108)2.72806969
52Hypoalphalipoproteinemia (HP:0003233)2.72208887
53Abnormality of the renal collecting system (HP:0004742)2.71391327
54Glomerulonephritis (HP:0000099)2.70716028
55Hyperbilirubinemia (HP:0002904)2.69503585
56Abnormality of methionine metabolism (HP:0010901)2.66773388
57Chronic obstructive pulmonary disease (HP:0006510)2.66120067
58Obstructive lung disease (HP:0006536)2.66120067
59Abnormality of the prostate (HP:0008775)2.65506749
60Amyloidosis (HP:0011034)2.61939790
61Abnormality of sulfur amino acid metabolism (HP:0004339)2.60735962
62Anorexia (HP:0002039)2.60314024
63T lymphocytopenia (HP:0005403)2.60218721
64Abnormality of T cell number (HP:0011839)2.58125437
65Abnormality of glycine metabolism (HP:0010895)2.58118437
66Abnormality of serine family amino acid metabolism (HP:0010894)2.58118437
67Abnormality of pyrimidine metabolism (HP:0004353)2.56784597
68Panhypogammaglobulinemia (HP:0003139)2.54883045
69Chronic mucocutaneous candidiasis (HP:0002728)2.52288772
70Recurrent cutaneous fungal infections (HP:0011370)2.52288772
71Abnormality of aspartate family amino acid metabolism (HP:0010899)2.52130831
72Abnormality of the 1st metacarpal (HP:0010009)2.51797960
73Spontaneous abortion (HP:0005268)2.51191033
74Petechiae (HP:0000967)2.51081193
75Abnormality of fatty-acid metabolism (HP:0004359)2.50254409
76Recurrent fungal infections (HP:0002841)2.48621268
77B lymphocytopenia (HP:0010976)2.47272100
78Recurrent abscess formation (HP:0002722)2.45739678
79Spontaneous hematomas (HP:0007420)2.43511426
80Loss of speech (HP:0002371)2.43247593
81Leukocytosis (HP:0001974)2.39922750
82Abnormality of the pleura (HP:0002103)2.38908386
83Epistaxis (HP:0000421)2.36159668
84Elevated erythrocyte sedimentation rate (HP:0003565)2.35865179
85Abnormality of proline metabolism (HP:0010907)2.33981662
86Hydroxyprolinuria (HP:0003080)2.33981662
87Ketoacidosis (HP:0001993)2.33368275
88Severe combined immunodeficiency (HP:0004430)2.32071699
89Abnormality of nucleobase metabolism (HP:0010932)2.31967440
90Thrombophlebitis (HP:0004418)2.31966898
91Myositis (HP:0100614)2.30172986
92Vacuolated lymphocytes (HP:0001922)2.29950915
93Increased IgE level (HP:0003212)2.27944889
94Steatorrhea (HP:0002570)2.27837008
95Eosinophilia (HP:0001880)2.27446764
96Vertigo (HP:0002321)2.26942461
97Increased cerebral lipofuscin (HP:0011813)2.26867631
98Granulocytopenia (HP:0001913)2.26712900
99Acanthocytosis (HP:0001927)2.26587845
100Abnormal delayed hypersensitivity skin test (HP:0002963)2.25543448
101Pulmonary embolism (HP:0002204)2.25348205
102Agammaglobulinemia (HP:0004432)2.22635756
103Gastrointestinal infarctions (HP:0005244)2.21889581
104Chronic otitis media (HP:0000389)2.21107883
105Increased serum ferritin (HP:0003281)2.20980665
106Joint swelling (HP:0001386)2.20589728
107Hypergammaglobulinemia (HP:0010702)2.20205693
108Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.19762348
109Fused cervical vertebrae (HP:0002949)2.19654232
110Abnormality of purine metabolism (HP:0004352)2.19558862
111Pancreatitis (HP:0001733)2.18858230
112Hypoglycemic seizures (HP:0002173)2.18491095
113Keratoconjunctivitis (HP:0001096)2.17857078
114Chest pain (HP:0100749)2.17665301
115Disinhibition (HP:0000734)2.17485172
116Menorrhagia (HP:0000132)2.15658057
117Episodic fever (HP:0001954)2.14185336
118Vasculitis (HP:0002633)2.14163321
119Recurrent bronchitis (HP:0002837)2.13832903
120Mitral stenosis (HP:0001718)2.13642833
121Abnormality of mucopolysaccharide metabolism (HP:0011020)2.13345533
122Abnormality of polysaccharide metabolism (HP:0011012)2.13345533
123Abnormality of glycosaminoglycan metabolism (HP:0004371)2.13345533
124Abnormal gallbladder morphology (HP:0012437)2.13096643
125Acute lymphatic leukemia (HP:0006721)2.10620326
126Cholelithiasis (HP:0001081)2.09935270
127Abnormality of macrophages (HP:0004311)2.07494012
128Abnormality of T cells (HP:0002843)2.07393034
129Autoimmune thrombocytopenia (HP:0001973)2.05632066
130Mucopolysacchariduria (HP:0008155)2.05532457
131Urinary glycosaminoglycan excretion (HP:0003541)2.05532457
132Polyneuropathy (HP:0001271)2.04904128
133Brushfield spots (HP:0001088)2.02172459
134Delayed CNS myelination (HP:0002188)2.01489235
135Metabolic acidosis (HP:0001942)2.01483844
136Pustule (HP:0200039)1.99184198
137Abnormality of eosinophils (HP:0001879)1.98628179
138IgG deficiency (HP:0004315)1.98048114
139Hepatocellular carcinoma (HP:0001402)1.97951323
140Abnormal rod and cone electroretinograms (HP:0008323)1.97909323
141Increased neuronal autofluorescent lipopigment (HP:0002074)1.96473796
142Acute hepatic failure (HP:0006554)1.96410441
143Abnormality of serum amino acid levels (HP:0003112)1.95620759
144Abnormality of transition element cation homeostasis (HP:0011030)1.95539732
145Abnormality of iron homeostasis (HP:0011031)1.92525870
146Colitis (HP:0002583)1.92244119
147Hypoplasia of the thymus (HP:0000778)1.91052777
148Poikilocytosis (HP:0004447)1.90559883
149Skin nodule (HP:0200036)1.90155984
150Urticaria (HP:0001025)1.89694104
151Elevated hepatic transaminases (HP:0002910)1.88096476
152Nasal polyposis (HP:0100582)1.88062976
153Increased IgM level (HP:0003496)1.87824362
154Orchitis (HP:0100796)1.87558150
155Recurrent viral infections (HP:0004429)1.87476678
156Purpura (HP:0000979)1.86490444
157Mediastinal lymphadenopathy (HP:0100721)1.86025353
158Arterial thrombosis (HP:0004420)1.83129220
159Nephritis (HP:0000123)1.83086330
160Meningitis (HP:0001287)1.82782571
161Sensorimotor neuropathy (HP:0007141)1.81763884
162Dicarboxylic aciduria (HP:0003215)1.80569219

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.26942120
2EIF2AK33.53532305
3TYK23.33226621
4FGFR43.06598103
5MAP3K132.98836161
6MAP4K12.71661976
7BCKDK2.65804709
8TBK12.61722940
9IKBKE2.46466447
10ERN12.38145809
11JAK12.38055911
12IRAK42.27914492
13RIPK42.25210354
14TAOK32.19017104
15IKBKB2.14777377
16JAK32.07838068
17IRAK32.00690775
18FLT31.93644164
19KIT1.93095657
20TXK1.91301382
21SIK11.73697626
22BLK1.69060313
23JAK21.63195697
24INSRR1.61380290
25SYK1.56845290
26BTK1.46439631
27CSF1R1.44703971
28GRK61.42827139
29ZAP701.33735677
30EPHB11.33664977
31TGFBR21.33114788
32ITK1.32426509
33TEC1.28892445
34CHUK1.27221041
35NLK1.27171015
36FGFR31.24302659
37BMPR21.21324899
38ARAF1.17650483
39EIF2AK21.13744935
40CSK1.13404032
41MAP3K121.10762683
42DAPK21.09794115
43IRAK11.08662913
44PRPF4B1.06724888
45MAPK111.05464056
46EPHA31.02836741
47FES1.02215388
48TAOK20.99474991
49SIK20.97828434
50MAPK150.96911939
51PTK60.93161556
52PRKAA20.90540840
53HCK0.89107615
54MAP2K40.87960983
55PIK3CG0.87642772
56LCK0.87623959
57FRK0.82403704
58LYN0.81409234
59TNK20.80334855
60TNIK0.79588386
61PRKCQ0.77206119
62MAP3K10.74289327
63CAMKK20.73975124
64FGR0.73222930
65ADRBK20.69419573
66DYRK1B0.68492725
67MAP3K70.68104457
68PIM20.67795588
69MAP4K20.67699561
70GRK70.66031548
71PRKD20.59706260
72ACVR1B0.59575009
73MAP3K30.58488885
74SIK30.56725663
75PDK10.55569063
76NME20.55291670
77TAOK10.54706104
78MAPK120.54249501
79PRKG20.53194499
80PINK10.52249469
81GRK50.52224685
82MAPK40.51318006
83PKN10.50265930
84STK380.49285188
85NEK90.48676268
86PIM10.48499728
87DAPK10.47740551
88MAP3K110.46441632
89KSR20.45531565
90INSR0.45272161
91RAF10.45239400
92MAP3K50.45128064
93CAMKK10.41635109
94ERBB30.41631896
95MAPK70.41144456
96MOS0.40680599
97MAP2K30.40468294
98MARK30.38157198
99IRAK20.38054163
100PRKCD0.37805061
101MAPKAPK20.37536014
102ABL20.37155182
103HIPK20.36070973
104MATK0.35988949
105PDPK10.35892950
106PRKACG0.35718478
107ABL10.35594428
108MAPK130.33470419
109DDR20.33382640
110MAP2K60.33341379
111KDR0.33116220
112IGF1R0.32899746
113RET0.32723211
114GRK10.32457577
115CDK190.32354427
116MST1R0.32056918
117RIPK10.31820284
118PRKCZ0.31707271
119PKN20.31050816
120MAP2K70.30755566
121MAP3K100.30362315
122MAP3K20.28390425
123SCYL20.28321038
124FYN0.26951160
125CDC42BPA0.26297317
126TRPM70.25793899
127STK110.24698831
128MAPK30.23802972

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.32408727
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.25182932
3Asthma_Homo sapiens_hsa053103.55390206
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.00476471
5Nitrogen metabolism_Homo sapiens_hsa009102.92968593
6Arginine biosynthesis_Homo sapiens_hsa002202.81870568
7Complement and coagulation cascades_Homo sapiens_hsa046102.61525522
8Tryptophan metabolism_Homo sapiens_hsa003802.54770171
9Staphylococcus aureus infection_Homo sapiens_hsa051502.53772227
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.27078568
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.23787768
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.08571294
13Rheumatoid arthritis_Homo sapiens_hsa053232.03875812
14Histidine metabolism_Homo sapiens_hsa003402.01842146
15Fatty acid degradation_Homo sapiens_hsa000711.97822310
16Caffeine metabolism_Homo sapiens_hsa002321.97728504
17Peroxisome_Homo sapiens_hsa041461.92136986
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.90445420
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.87526683
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.83635743
21Hematopoietic cell lineage_Homo sapiens_hsa046401.81369333
22PPAR signaling pathway_Homo sapiens_hsa033201.70808561
23Chemical carcinogenesis_Homo sapiens_hsa052041.68090617
24Malaria_Homo sapiens_hsa051441.67573368
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.63125994
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.62210184
27Phenylalanine metabolism_Homo sapiens_hsa003601.61122595
28beta-Alanine metabolism_Homo sapiens_hsa004101.55441679
29ABC transporters_Homo sapiens_hsa020101.51858233
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.51211160
31Butanoate metabolism_Homo sapiens_hsa006501.46282601
32Retinol metabolism_Homo sapiens_hsa008301.42649066
33Propanoate metabolism_Homo sapiens_hsa006401.40225747
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.38241845
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34733187
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.26894717
37Herpes simplex infection_Homo sapiens_hsa051681.26798557
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.25002619
39Viral myocarditis_Homo sapiens_hsa054161.21326630
40Folate biosynthesis_Homo sapiens_hsa007901.20963862
41Tyrosine metabolism_Homo sapiens_hsa003501.19257294
42Fatty acid metabolism_Homo sapiens_hsa012121.19226559
43Bile secretion_Homo sapiens_hsa049761.19121158
44Primary immunodeficiency_Homo sapiens_hsa053401.13365637
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.13183142
46Starch and sucrose metabolism_Homo sapiens_hsa005001.11149863
47Selenocompound metabolism_Homo sapiens_hsa004501.06242285
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05544089
49Intestinal immune network for IgA production_Homo sapiens_hsa046721.05088429
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.02315876
51Platelet activation_Homo sapiens_hsa046110.95507771
52Sulfur metabolism_Homo sapiens_hsa009200.95240349
53NF-kappa B signaling pathway_Homo sapiens_hsa040640.94938429
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94345472
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.93618517
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.91700739
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88694744
58Fat digestion and absorption_Homo sapiens_hsa049750.87890672
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87204802
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84772015
61Allograft rejection_Homo sapiens_hsa053300.82319409
62Hepatitis C_Homo sapiens_hsa051600.81345213
63Fatty acid elongation_Homo sapiens_hsa000620.79626537
64Leishmaniasis_Homo sapiens_hsa051400.79574373
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79236763
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76086131
67Pyruvate metabolism_Homo sapiens_hsa006200.75282659
68Sulfur relay system_Homo sapiens_hsa041220.72462521
69Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71463869
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.70917893
71Salmonella infection_Homo sapiens_hsa051320.70654301
72Vitamin digestion and absorption_Homo sapiens_hsa049770.69136618
73Osteoclast differentiation_Homo sapiens_hsa043800.69000846
74Glycerolipid metabolism_Homo sapiens_hsa005610.67811326
75Arachidonic acid metabolism_Homo sapiens_hsa005900.67521654
76RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66496313
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66039230
78Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64934569
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64390121
80Linoleic acid metabolism_Homo sapiens_hsa005910.63829103
81Systemic lupus erythematosus_Homo sapiens_hsa053220.63669117
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63431587
83B cell receptor signaling pathway_Homo sapiens_hsa046620.62895227
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61751517
85Renin-angiotensin system_Homo sapiens_hsa046140.61139035
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60730082
87Hepatitis B_Homo sapiens_hsa051610.59991730
88Phagosome_Homo sapiens_hsa041450.59917028
89Vitamin B6 metabolism_Homo sapiens_hsa007500.58613030
90Measles_Homo sapiens_hsa051620.58090017
91Salivary secretion_Homo sapiens_hsa049700.56638559
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.53702062
93African trypanosomiasis_Homo sapiens_hsa051430.52960742
94Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52927564
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52823552
96Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52609075
97Serotonergic synapse_Homo sapiens_hsa047260.51783901
98Renin secretion_Homo sapiens_hsa049240.51475093
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51451903
100Biosynthesis of amino acids_Homo sapiens_hsa012300.51290403
101Acute myeloid leukemia_Homo sapiens_hsa052210.50102447
102Arginine and proline metabolism_Homo sapiens_hsa003300.49694478
103Graft-versus-host disease_Homo sapiens_hsa053320.47628443
104Antigen processing and presentation_Homo sapiens_hsa046120.47552259
105Carbon metabolism_Homo sapiens_hsa012000.46093768
106Pertussis_Homo sapiens_hsa051330.42855569
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41958857
108Jak-STAT signaling pathway_Homo sapiens_hsa046300.41444778
109Autoimmune thyroid disease_Homo sapiens_hsa053200.40263511
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40111252
111Prolactin signaling pathway_Homo sapiens_hsa049170.38117964
112Calcium signaling pathway_Homo sapiens_hsa040200.38009462
113Prion diseases_Homo sapiens_hsa050200.37963573
114Glycosaminoglycan degradation_Homo sapiens_hsa005310.37543200
115Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.36867712
116TNF signaling pathway_Homo sapiens_hsa046680.36470289
117Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.36462515
118Insulin resistance_Homo sapiens_hsa049310.36188357
119Lysine degradation_Homo sapiens_hsa003100.35336664
120VEGF signaling pathway_Homo sapiens_hsa043700.34772441
121Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33734237
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.33487501
123Pentose phosphate pathway_Homo sapiens_hsa000300.33061447
124Tuberculosis_Homo sapiens_hsa051520.32819426
125Type II diabetes mellitus_Homo sapiens_hsa049300.32373375
126Amoebiasis_Homo sapiens_hsa051460.31487722
127Type I diabetes mellitus_Homo sapiens_hsa049400.31343959
128Influenza A_Homo sapiens_hsa051640.30718840
129Chemokine signaling pathway_Homo sapiens_hsa040620.29799164
130Lysosome_Homo sapiens_hsa041420.29751865
131Toxoplasmosis_Homo sapiens_hsa051450.29600009
132Epstein-Barr virus infection_Homo sapiens_hsa051690.29134579
133Olfactory transduction_Homo sapiens_hsa047400.28407211
134Shigellosis_Homo sapiens_hsa051310.28290698
135Apoptosis_Homo sapiens_hsa042100.27381260
136Legionellosis_Homo sapiens_hsa051340.27180132
137Glycerophospholipid metabolism_Homo sapiens_hsa005640.26936183
138HTLV-I infection_Homo sapiens_hsa051660.26827521
139Steroid biosynthesis_Homo sapiens_hsa001000.26644709
140cAMP signaling pathway_Homo sapiens_hsa040240.25240511
141Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.24329219
142Sphingolipid signaling pathway_Homo sapiens_hsa040710.23798526
143Other glycan degradation_Homo sapiens_hsa005110.23644847
144Metabolic pathways_Homo sapiens_hsa011000.23231086
145Leukocyte transendothelial migration_Homo sapiens_hsa046700.22929832
146T cell receptor signaling pathway_Homo sapiens_hsa046600.22602428

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