MZT2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)7.79463159
2viral transcription (GO:0019083)6.88008619
3translational termination (GO:0006415)6.47580142
4ribosomal small subunit assembly (GO:0000028)6.08252069
5translational elongation (GO:0006414)5.80172321
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.57729966
7cotranslational protein targeting to membrane (GO:0006613)5.45411485
8protein targeting to ER (GO:0045047)5.45219322
9deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.32512524
10maturation of SSU-rRNA (GO:0030490)5.28893437
11GTP biosynthetic process (GO:0006183)5.27293400
12pyrimidine deoxyribonucleotide catabolic process (GO:0009223)5.23799525
13protein complex biogenesis (GO:0070271)5.20224582
14establishment of protein localization to endoplasmic reticulum (GO:0072599)5.19025214
15energy coupled proton transport, down electrochemical gradient (GO:0015985)5.18019621
16ATP synthesis coupled proton transport (GO:0015986)5.18019621
17mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.15826569
18UTP biosynthetic process (GO:0006228)5.14556159
19protein localization to endoplasmic reticulum (GO:0070972)5.13597028
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.07613922
21mitochondrial respiratory chain complex I assembly (GO:0032981)5.07613922
22NADH dehydrogenase complex assembly (GO:0010257)5.07613922
23viral life cycle (GO:0019058)5.07304159
24cellular protein complex disassembly (GO:0043624)4.96818551
25mitochondrial respiratory chain complex assembly (GO:0033108)4.92295295
26nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.86508483
27UTP metabolic process (GO:0046051)4.72220287
28mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.60123428
29respiratory electron transport chain (GO:0022904)4.55644376
30guanosine-containing compound biosynthetic process (GO:1901070)4.55572216
31electron transport chain (GO:0022900)4.51442539
32chaperone-mediated protein transport (GO:0072321)4.45318114
33pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)4.43606638
34pyrimidine nucleoside triphosphate metabolic process (GO:0009147)4.43506506
35base-excision repair, AP site formation (GO:0006285)4.42580644
36protein complex disassembly (GO:0043241)4.40400757
37translational initiation (GO:0006413)4.40323335
38pyrimidine nucleotide catabolic process (GO:0006244)4.37207160
39CTP biosynthetic process (GO:0006241)4.31585547
40CTP metabolic process (GO:0046036)4.31585547
41pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)4.27703532
42regulation of mitochondrial translation (GO:0070129)4.19160152
43establishment of protein localization to mitochondrial membrane (GO:0090151)4.18057689
44macromolecular complex disassembly (GO:0032984)4.14396462
45pseudouridine synthesis (GO:0001522)4.08130547
46cellular component biogenesis (GO:0044085)4.02705732
47pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)4.01079869
48translation (GO:0006412)3.99762879
49pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.96090947
50purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.87487535
51ribonucleoprotein complex biogenesis (GO:0022613)3.87287149
52protein targeting to mitochondrion (GO:0006626)3.86047467
53purine nucleoside triphosphate biosynthetic process (GO:0009145)3.79537131
54cytochrome complex assembly (GO:0017004)3.74657362
55establishment of protein localization to mitochondrion (GO:0072655)3.72279419
56ribonucleoside triphosphate biosynthetic process (GO:0009201)3.70455706
57peptidyl-histidine modification (GO:0018202)3.66440251
58protein targeting to membrane (GO:0006612)3.64110882
59ncRNA 3-end processing (GO:0043628)3.56099475
60RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.51881248
61tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.51881248
62respiratory chain complex IV assembly (GO:0008535)3.50087821
63metallo-sulfur cluster assembly (GO:0031163)3.46289868
64iron-sulfur cluster assembly (GO:0016226)3.46289868
65protein neddylation (GO:0045116)3.43640151
66ATP biosynthetic process (GO:0006754)3.43338314
67ribosomal large subunit biogenesis (GO:0042273)3.39008971
68rRNA processing (GO:0006364)3.38501632
69deoxyribonucleotide catabolic process (GO:0009264)3.37480509
70transcription elongation from RNA polymerase III promoter (GO:0006385)3.35382818
71termination of RNA polymerase III transcription (GO:0006386)3.35382818
72nuclear-transcribed mRNA catabolic process (GO:0000956)3.34752327
73protein localization to mitochondrion (GO:0070585)3.33862192
74DNA deamination (GO:0045006)3.27281653
75rRNA metabolic process (GO:0016072)3.26896478
76oxidative phosphorylation (GO:0006119)3.23985041
77nucleoside triphosphate biosynthetic process (GO:0009142)3.20029010
78mRNA catabolic process (GO:0006402)3.19731918
79GMP metabolic process (GO:0046037)3.19236494
80pyrimidine nucleotide biosynthetic process (GO:0006221)3.07421772
81pyrimidine ribonucleoside biosynthetic process (GO:0046132)3.05800657
82deoxyribose phosphate catabolic process (GO:0046386)3.03377470
83transcription from mitochondrial promoter (GO:0006390)2.98559522
84tRNA processing (GO:0008033)2.97805681
85RNA catabolic process (GO:0006401)2.96830533
86negative regulation of telomere maintenance (GO:0032205)2.95851721
87hydrogen ion transmembrane transport (GO:1902600)2.95046382
88mitochondrial transport (GO:0006839)2.92522850
89RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.92457537
90GDP-mannose metabolic process (GO:0019673)2.89650867
91tRNA modification (GO:0006400)2.89582786
92negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.88934928
932-deoxyribonucleotide metabolic process (GO:0009394)2.87083970
94pyrimidine ribonucleotide biosynthetic process (GO:0009220)2.86697469
95nucleoside diphosphate phosphorylation (GO:0006165)2.86135745
96inner mitochondrial membrane organization (GO:0007007)2.85930180
97pyrimidine nucleotide metabolic process (GO:0006220)2.85588234
98ncRNA processing (GO:0034470)2.83572851
99protein targeting (GO:0006605)2.82432652
100rRNA modification (GO:0000154)2.81975295

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.75931510
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.37302947
3JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.34182667
4MYC_18555785_ChIP-Seq_MESCs_Mouse2.99541464
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.91141601
6ETS1_20019798_ChIP-Seq_JURKAT_Human2.85244435
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.62141950
8MYC_18358816_ChIP-ChIP_MESCs_Mouse2.60930707
9XRN2_22483619_ChIP-Seq_HELA_Human2.46779692
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.41085811
11THAP11_20581084_ChIP-Seq_MESCs_Mouse2.32455567
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.31363935
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.29481079
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.28474253
15VDR_21846776_ChIP-Seq_THP-1_Human2.15467751
16CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.15311940
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.11125252
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.10969459
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.08659440
20GABP_19822575_ChIP-Seq_HepG2_Human2.05646602
21TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97771602
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.95878562
23TET1_21451524_ChIP-Seq_MESCs_Mouse1.90667170
24YY1_21170310_ChIP-Seq_MESCs_Mouse1.86218167
25P68_20966046_ChIP-Seq_HELA_Human1.81158707
26MYC_19030024_ChIP-ChIP_MESCs_Mouse1.79607134
27LXR_22292898_ChIP-Seq_THP-1_Human1.79579525
28E2F7_22180533_ChIP-Seq_HELA_Human1.79538820
29CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.77823033
30TTF2_22483619_ChIP-Seq_HELA_Human1.77697947
31PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.75840896
32DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.71718024
33DCP1A_22483619_ChIP-Seq_HELA_Human1.71659574
34SRY_22984422_ChIP-ChIP_TESTIS_Rat1.67356431
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.66988739
36SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.66571832
37MYC_19079543_ChIP-ChIP_MESCs_Mouse1.65964965
38CTCF_18555785_ChIP-Seq_MESCs_Mouse1.61776194
39FOXP3_21729870_ChIP-Seq_TREG_Human1.60674905
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.57891857
41BCL6_27268052_Chip-Seq_Bcells_Human1.57632878
42FOXP1_21924763_ChIP-Seq_HESCs_Human1.56098751
43KDM5A_27292631_Chip-Seq_BREAST_Human1.55026173
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.53487453
45VDR_23849224_ChIP-Seq_CD4+_Human1.53218653
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.49274009
47ELF1_20517297_ChIP-Seq_JURKAT_Human1.49232162
48CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.48326474
49E2F1_18555785_ChIP-Seq_MESCs_Mouse1.47741067
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.47528742
51EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.46213631
52MYC_22102868_ChIP-Seq_BL_Human1.41233332
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.40208507
54ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.38238645
55PHF8_20622854_ChIP-Seq_HELA_Human1.36752676
56ZNF263_19887448_ChIP-Seq_K562_Human1.35334822
57SA1_27219007_Chip-Seq_ERYTHROID_Human1.33711278
58E2F1_20622854_ChIP-Seq_HELA_Human1.32982190
59BCOR_27268052_Chip-Seq_Bcells_Human1.31835237
60CTCF_26484167_Chip-Seq_Bcells_Mouse1.31420511
61MYC_18940864_ChIP-ChIP_HL60_Human1.29589607
62YY1_22570637_ChIP-Seq_MALME-3M_Human1.29444842
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28819446
64RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.28619432
65SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.28280623
66CTCF_27219007_Chip-Seq_Bcells_Human1.28060314
67CIITA_25753668_ChIP-Seq_RAJI_Human1.24285297
68KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.23478548
69CTCF_20526341_ChIP-Seq_ESCs_Human1.22249628
70BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.21466203
71SA1_27219007_Chip-Seq_Bcells_Human1.21319955
72ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.20772397
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19546006
74NELFA_20434984_ChIP-Seq_ESCs_Mouse1.16605710
75CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.13299573
76SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.12060228
77SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.10865379
78SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10263314
79FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.09660690
80ERA_21632823_ChIP-Seq_H3396_Human1.08478132
81SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08014834
82CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07677617
83ERG_21242973_ChIP-ChIP_JURKAT_Human1.07641094
84MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.07199333
85MAF_26560356_Chip-Seq_TH2_Human1.06848708
86ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05899713
87SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04827850
88CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.04730149
89POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.03560980
90CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03048450
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02060511
92SMC4_20622854_ChIP-Seq_HELA_Human0.99962980
93P300_27268052_Chip-Seq_Bcells_Human0.99741498
94RARA_24833708_ChIP-Seq_LIVER_Mouse0.99025552
95POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98533972
96CTCF_21964334_Chip-Seq_Bcells_Human0.98139202
97RARB_24833708_ChIP-Seq_LIVER_Mouse0.97361922
98TAF2_19829295_ChIP-Seq_ESCs_Human0.95944727
99MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.95850621
100MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.95784319

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.98564521
2MP0002163_abnormal_gland_morphology3.60033574
3MP0003123_paternal_imprinting3.37274221
4MP0006292_abnormal_olfactory_placode3.17134776
5MP0002234_abnormal_pharynx_morphology2.66323190
6MP0002160_abnormal_reproductive_system2.22523250
7MP0005379_endocrine/exocrine_gland_phen2.01441049
8MP0005646_abnormal_pituitary_gland2.01173261
9MP0003787_abnormal_imprinting1.97048371
10MP0000678_abnormal_parathyroid_gland1.96420523
11MP0003693_abnormal_embryo_hatching1.95607513
12MP0002837_dystrophic_cardiac_calcinosis1.92936130
13MP0008058_abnormal_DNA_repair1.92446584
14MP0006036_abnormal_mitochondrial_physio1.89169085
15MP0005645_abnormal_hypothalamus_physiol1.82870406
16MP0001905_abnormal_dopamine_level1.76093817
17MP0001529_abnormal_vocalization1.70974450
18MP0000049_abnormal_middle_ear1.70341925
19MP0001968_abnormal_touch/_nociception1.68250579
20MP0004133_heterotaxia1.65999911
21MP0005389_reproductive_system_phenotype1.65187507
22MP0002736_abnormal_nociception_after1.60158691
23MP0002653_abnormal_ependyma_morphology1.53696355
24MP0001919_abnormal_reproductive_system1.51738134
25MP0004145_abnormal_muscle_electrophysio1.44481385
26MP0003186_abnormal_redox_activity1.40758099
27MP0004858_abnormal_nervous_system1.40548375
28MP0002249_abnormal_larynx_morphology1.39631753
29MP0008872_abnormal_physiological_respon1.39630612
30MP0003786_premature_aging1.38538073
31MP0000566_synostosis1.38426798
32MP0006276_abnormal_autonomic_nervous1.38391347
33MP0001188_hyperpigmentation1.37917365
34MP0010094_abnormal_chromosome_stability1.37154050
35MP0003121_genomic_imprinting1.35997805
36MP0003111_abnormal_nucleus_morphology1.35792231
37MP0004142_abnormal_muscle_tone1.34241293
38MP0002876_abnormal_thyroid_physiology1.31972867
39MP0000631_abnormal_neuroendocrine_gland1.28855561
40MP0002822_catalepsy1.27622990
41MP0005670_abnormal_white_adipose1.24604137
42MP0005394_taste/olfaction_phenotype1.24357740
43MP0005499_abnormal_olfactory_system1.24357740
44MP0002938_white_spotting1.23228921
45MP0008932_abnormal_embryonic_tissue1.22552509
46MP0002557_abnormal_social/conspecific_i1.21860648
47MP0008789_abnormal_olfactory_epithelium1.20936472
48MP0006035_abnormal_mitochondrial_morpho1.20786435
49MP0001944_abnormal_pancreas_morphology1.16579123
50MP0005451_abnormal_body_composition1.15038836
51MP0005423_abnormal_somatic_nervous1.14418343
52MP0003880_abnormal_central_pattern1.13843085
53MP0008875_abnormal_xenobiotic_pharmacok1.12278088
54MP0009046_muscle_twitch1.12240977
55MP0009745_abnormal_behavioral_response1.11772132
56MP0002210_abnormal_sex_determination1.09424646
57MP0009053_abnormal_anal_canal1.09114985
58MP0000681_abnormal_thyroid_gland1.09031005
59MP0003315_abnormal_perineum_morphology1.08283422
60MP0009333_abnormal_splenocyte_physiolog1.08261526
61MP0000538_abnormal_urinary_bladder1.06106014
62MP0000372_irregular_coat_pigmentation1.05295608
63MP0005551_abnormal_eye_electrophysiolog1.04921348
64MP0005220_abnormal_exocrine_pancreas1.03738667
65MP0003122_maternal_imprinting1.03083431
66MP0002733_abnormal_thermal_nociception1.00785636
67MP0003283_abnormal_digestive_organ1.00209222
68MP0001764_abnormal_homeostasis0.97909228
69MP0003938_abnormal_ear_development0.96526021
70MP0002064_seizures0.95954046
71MP0005332_abnormal_amino_acid0.95846372
72MP0003942_abnormal_urinary_system0.94955376
73MP0004147_increased_porphyrin_level0.93738998
74MP0002184_abnormal_innervation0.88593198
75MP0002693_abnormal_pancreas_physiology0.88489798
76MP0010030_abnormal_orbit_morphology0.88000643
77MP0001873_stomach_inflammation0.87659551
78MP0008995_early_reproductive_senescence0.87182995
79MP0003646_muscle_fatigue0.86636227
80MP0002272_abnormal_nervous_system0.84348626
81MP0003077_abnormal_cell_cycle0.84087988
82MP0001348_abnormal_lacrimal_gland0.83102886
83MP0001145_abnormal_male_reproductive0.82910869
84MP0003011_delayed_dark_adaptation0.82069664
85MP0002752_abnormal_somatic_nervous0.80813796
86MP0000026_abnormal_inner_ear0.79691212
87MP0005360_urolithiasis0.78486234
88MP0001970_abnormal_pain_threshold0.78193909
89MP0001270_distended_abdomen0.76965725
90MP0002572_abnormal_emotion/affect_behav0.76922424
91MP0003137_abnormal_impulse_conducting0.74583890
92MP0000653_abnormal_sex_gland0.72157867
93MP0002928_abnormal_bile_duct0.70771208
94MP0006072_abnormal_retinal_apoptosis0.70741344
95MP0003698_abnormal_male_reproductive0.69682512
96MP0005195_abnormal_posterior_eye0.69550895
97MP0000955_abnormal_spinal_cord0.69471812
98MP0003635_abnormal_synaptic_transmissio0.69024292
99MP0002063_abnormal_learning/memory/cond0.68575928
100MP0000750_abnormal_muscle_regeneration0.68218786

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.13020338
2Abnormal mitochondria in muscle tissue (HP:0008316)5.00597835
3Mitochondrial inheritance (HP:0001427)4.86843734
4Acute encephalopathy (HP:0006846)4.53721310
5Hepatocellular necrosis (HP:0001404)4.50186234
6Abnormality of cells of the erythroid lineage (HP:0012130)4.45847950
7Abnormal number of erythroid precursors (HP:0012131)4.36579834
8Increased CSF lactate (HP:0002490)4.36080151
9Hepatic necrosis (HP:0002605)4.33207792
10Progressive macrocephaly (HP:0004481)4.11112365
11Reticulocytopenia (HP:0001896)4.00349283
12Increased intramyocellular lipid droplets (HP:0012240)3.52640878
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.51865156
14Decreased activity of mitochondrial respiratory chain (HP:0008972)3.51865156
15Increased hepatocellular lipid droplets (HP:0006565)3.44970182
16Lipid accumulation in hepatocytes (HP:0006561)3.42004149
17Hyperthyroidism (HP:0000836)3.36560867
18Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.31625467
19Increased muscle lipid content (HP:0009058)3.30780037
20Renal Fanconi syndrome (HP:0001994)3.27529218
21Microretrognathia (HP:0000308)3.17416849
22Increased serum lactate (HP:0002151)3.16345270
23Cerebral edema (HP:0002181)3.08881862
24Lactic acidosis (HP:0003128)3.05425212
253-Methylglutaconic aciduria (HP:0003535)2.99553753
26Macrocytic anemia (HP:0001972)2.98838925
27Type II lissencephaly (HP:0007260)2.84518631
28Exercise intolerance (HP:0003546)2.73624215
29Aplasia/Hypoplasia of the sacrum (HP:0008517)2.73577810
30Respiratory failure (HP:0002878)2.64156940
31Testicular atrophy (HP:0000029)2.55681927
32Pallor (HP:0000980)2.54762079
33Absent thumb (HP:0009777)2.51850773
34Absent rod-and cone-mediated responses on ERG (HP:0007688)2.50421248
35Broad distal phalanx of finger (HP:0009836)2.48065905
36Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.46576307
37Respiratory difficulties (HP:0002880)2.40617202
38Squamous cell carcinoma (HP:0002860)2.34928829
39Optic disc pallor (HP:0000543)2.34801242
40Myokymia (HP:0002411)2.29503042
41Truncus arteriosus (HP:0001660)2.28752020
42Progressive microcephaly (HP:0000253)2.26322335
43Microvesicular hepatic steatosis (HP:0001414)2.25452217
44Congenital malformation of the right heart (HP:0011723)2.23368376
45Double outlet right ventricle (HP:0001719)2.23368376
46Congenital stationary night blindness (HP:0007642)2.21017781
47Concave nail (HP:0001598)2.20010649
48Dicarboxylic aciduria (HP:0003215)2.19951761
49Abnormality of dicarboxylic acid metabolism (HP:0010995)2.19951761
50Abnormal rod and cone electroretinograms (HP:0008323)2.17519304
51Exertional dyspnea (HP:0002875)2.16749402
52Aplasia/Hypoplasia of the patella (HP:0006498)2.15149395
53Retinal dysplasia (HP:0007973)2.14873527
54Molar tooth sign on MRI (HP:0002419)2.14416928
55Abnormality of midbrain morphology (HP:0002418)2.14416928
56Emotional lability (HP:0000712)2.12654858
57Severe muscular hypotonia (HP:0006829)2.12297972
58Leukodystrophy (HP:0002415)2.06960406
59Sclerocornea (HP:0000647)2.06597791
60Cerebral hypomyelination (HP:0006808)2.02457981
61Hyperglycinemia (HP:0002154)2.00882232
62Generalized aminoaciduria (HP:0002909)2.00848737
63Glycosuria (HP:0003076)2.00374131
64Abnormality of urine glucose concentration (HP:0011016)2.00374131
65Lethargy (HP:0001254)1.98475842
66Renal cortical cysts (HP:0000803)1.96396410
67CNS demyelination (HP:0007305)1.94858285
68Pancreatic fibrosis (HP:0100732)1.90672265
69Abnormality of magnesium homeostasis (HP:0004921)1.89786691
70Patellar aplasia (HP:0006443)1.86886073
71Opisthotonus (HP:0002179)1.86116312
72Aplastic anemia (HP:0001915)1.84116732
73Cerebellar dysplasia (HP:0007033)1.83671904
74Pendular nystagmus (HP:0012043)1.83142900
75Pancreatic cysts (HP:0001737)1.83037743
76Abnormality of DNA repair (HP:0003254)1.82661940
77Ketosis (HP:0001946)1.82462232
78Cleft eyelid (HP:0000625)1.81450164
79Pancytopenia (HP:0001876)1.76647860
80Horseshoe kidney (HP:0000085)1.75903176
81Abnormality of renal resorption (HP:0011038)1.75806556
82Rectal prolapse (HP:0002035)1.72351408
83Abnormal protein glycosylation (HP:0012346)1.71984458
84Abnormal glycosylation (HP:0012345)1.71984458
85Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.71984458
86Abnormal protein N-linked glycosylation (HP:0012347)1.71984458
87Hypoplasia of the radius (HP:0002984)1.69191595
88Pachygyria (HP:0001302)1.68186602
89Lissencephaly (HP:0001339)1.67872042
90Abnormality of the aortic arch (HP:0012303)1.65996160
91Abnormality of alanine metabolism (HP:0010916)1.61036779
92Hyperalaninemia (HP:0003348)1.61036779
93Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.61036779
94Gliosis (HP:0002171)1.60811249
95Cerebral palsy (HP:0100021)1.58555886
96Methylmalonic aciduria (HP:0012120)1.58389351
97Delayed CNS myelination (HP:0002188)1.57904952
98Septate vagina (HP:0001153)1.57442601
99Blindness (HP:0000618)1.57383086
100Abnormality of the renal cortex (HP:0011035)1.57186604

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.58757981
2TLK14.04314270
3STK163.76179322
4VRK23.21056529
5BCKDK2.57060236
6ZAK2.45331825
7PIM22.38358654
8MAP3K112.04866594
9TRIB31.96528439
10KDR1.89719865
11IRAK31.88397059
12SMG11.78306088
13ARAF1.76957617
14BUB11.76607389
15DYRK21.74384037
16TESK21.70078676
17ABL21.60357101
18WNK41.56945337
19ILK1.55915179
20VRK11.52385984
21RPS6KA51.51843492
22NME11.49963143
23AURKA1.43025208
24PRKCI1.36598923
25LRRK21.32874997
26BRAF1.32010130
27MAP4K21.31754235
28CDC71.30640260
29ADRBK21.29597253
30CHEK21.26842544
31CSNK1G31.19292301
32DAPK31.16449703
33SIK11.04229537
34RPS6KB21.04021964
35GRK11.03650665
36CDK80.99643359
37FRK0.98087291
38MAP4K10.97514684
39ATR0.95829832
40MUSK0.94702605
41ICK0.92772581
42CAMKK10.92623294
43IKBKB0.86208861
44MAP2K70.85681372
45MAP2K60.85313095
46SIK20.85250865
47CSNK1G20.84879206
48MAPKAPK30.82939157
49STK40.82780330
50PKN10.79809093
51BRSK10.79754783
52INSRR0.78373002
53RPS6KA60.78302954
54CSNK1A1L0.75969023
55CSNK1G10.75570274
56MAPK130.75415521
57PRKD30.75221819
58MAP2K20.73227780
59HIPK20.71917628
60PINK10.70929424
61EEF2K0.68511049
62CAMK10.68254314
63TAOK20.68125619
64MAPK110.67894149
65RPS6KC10.67583492
66RPS6KL10.67583492
67PHKG10.66200657
68PHKG20.66200657
69DAPK10.63952230
70ERN10.63720334
71CDK70.63207224
72LIMK10.59823639
73NEK20.59819784
74NUAK10.59191996
75TNK20.57327286
76AURKB0.55974934
77CSNK2A20.55531656
78CDK190.54782282
79TESK10.54635738
80BMPR1B0.53209653
81PLK10.52767182
82CSNK2A10.51740558
83AKT20.51584755
84PRKCG0.51046526
85DAPK20.49758113
86RPS6KA20.46743045
87CSNK1A10.46560023
88IRAK20.46130635
89TXK0.45317233
90ADRBK10.44661489
91PAK10.43383722
92PKN20.43225882
93GRK60.40242711
94RPS6KA10.38316305
95RPS6KA40.38226572
96CCNB10.38114507
97CAMKK20.37933940
98STK110.37829922
99MINK10.37225015
100EPHB20.36823063

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.09936517
2Oxidative phosphorylation_Homo sapiens_hsa001904.61858076
3Sulfur relay system_Homo sapiens_hsa041223.89841980
4Parkinsons disease_Homo sapiens_hsa050123.75037907
5RNA polymerase_Homo sapiens_hsa030202.91396355
6DNA replication_Homo sapiens_hsa030302.83167677
7Huntingtons disease_Homo sapiens_hsa050162.69699907
8Base excision repair_Homo sapiens_hsa034102.55208663
9Alzheimers disease_Homo sapiens_hsa050102.54152513
10Pyrimidine metabolism_Homo sapiens_hsa002402.52171078
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.45194321
12Proteasome_Homo sapiens_hsa030502.15645042
13Homologous recombination_Homo sapiens_hsa034402.02178336
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.96941631
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.92444371
16Cardiac muscle contraction_Homo sapiens_hsa042601.91710156
17One carbon pool by folate_Homo sapiens_hsa006701.85557513
18Fanconi anemia pathway_Homo sapiens_hsa034601.57301118
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.49476782
20Cyanoamino acid metabolism_Homo sapiens_hsa004601.49145330
21Systemic lupus erythematosus_Homo sapiens_hsa053221.44584465
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.42766107
23Spliceosome_Homo sapiens_hsa030401.34091245
24Purine metabolism_Homo sapiens_hsa002301.30299056
25Nucleotide excision repair_Homo sapiens_hsa034201.28250154
26Mismatch repair_Homo sapiens_hsa034301.27214247
27Sulfur metabolism_Homo sapiens_hsa009201.24003263
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.22266794
29Folate biosynthesis_Homo sapiens_hsa007901.12484082
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.10951276
31Protein export_Homo sapiens_hsa030601.09509707
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.07186474
33Alcoholism_Homo sapiens_hsa050341.05865188
34Phototransduction_Homo sapiens_hsa047441.04944953
35Vitamin B6 metabolism_Homo sapiens_hsa007501.00779181
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99456949
37Metabolic pathways_Homo sapiens_hsa011000.98624196
38Arginine and proline metabolism_Homo sapiens_hsa003300.94088196
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93796776
40Collecting duct acid secretion_Homo sapiens_hsa049660.93781618
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87244521
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.86638257
43Butanoate metabolism_Homo sapiens_hsa006500.85142356
44Selenocompound metabolism_Homo sapiens_hsa004500.83117999
45Primary immunodeficiency_Homo sapiens_hsa053400.80528428
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79380369
47RNA degradation_Homo sapiens_hsa030180.76557390
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75470205
49Peroxisome_Homo sapiens_hsa041460.74465927
50Biosynthesis of amino acids_Homo sapiens_hsa012300.71099056
51RNA transport_Homo sapiens_hsa030130.70691066
52Synaptic vesicle cycle_Homo sapiens_hsa047210.68956004
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67465272
54Fatty acid elongation_Homo sapiens_hsa000620.65982191
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64676036
56Glutathione metabolism_Homo sapiens_hsa004800.63928466
57Pyruvate metabolism_Homo sapiens_hsa006200.62020852
58Steroid biosynthesis_Homo sapiens_hsa001000.60393692
59N-Glycan biosynthesis_Homo sapiens_hsa005100.59809293
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59518882
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58634357
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55404495
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54196844
64Fructose and mannose metabolism_Homo sapiens_hsa000510.53783505
65Basal transcription factors_Homo sapiens_hsa030220.51897331
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49488437
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48835531
68Tryptophan metabolism_Homo sapiens_hsa003800.47328099
69Fat digestion and absorption_Homo sapiens_hsa049750.44037988
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.43628889
71Carbon metabolism_Homo sapiens_hsa012000.42094631
72Linoleic acid metabolism_Homo sapiens_hsa005910.39629760
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37491200
74Phenylalanine metabolism_Homo sapiens_hsa003600.35228080
75Nitrogen metabolism_Homo sapiens_hsa009100.30975136
76Vibrio cholerae infection_Homo sapiens_hsa051100.28903436
77Non-homologous end-joining_Homo sapiens_hsa034500.28401001
78Galactose metabolism_Homo sapiens_hsa000520.28089202
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.27435078
80Asthma_Homo sapiens_hsa053100.27263926
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26791974
82Tyrosine metabolism_Homo sapiens_hsa003500.26355728
83Ether lipid metabolism_Homo sapiens_hsa005650.25625515
84Arachidonic acid metabolism_Homo sapiens_hsa005900.23721137
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.23110299
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22588660
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.21943378
88beta-Alanine metabolism_Homo sapiens_hsa004100.21092433
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20246655
90Glycerolipid metabolism_Homo sapiens_hsa005610.18570579
91Pentose phosphate pathway_Homo sapiens_hsa000300.18101543
92Propanoate metabolism_Homo sapiens_hsa006400.17385779
93Arginine biosynthesis_Homo sapiens_hsa002200.16604536
94p53 signaling pathway_Homo sapiens_hsa041150.15603721
95Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.15290528
96Cell cycle_Homo sapiens_hsa041100.14784976
97Epstein-Barr virus infection_Homo sapiens_hsa051690.12458779
98Lysine degradation_Homo sapiens_hsa003100.12034148
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.10804514
100Basal cell carcinoma_Homo sapiens_hsa052170.10742458

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