MYO7B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is found in brush border microvilli of epithelial cells in the intestines and kidneys. The encoded protein is involved in linking protocadherins to the actin cytoskeleton and is essential for proper microvilli function. This protein aids in the accumulation of intermicrovillar adhesion components such as harmonin and ANKS4B, and this accumulation is necessary for normal brush border action. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1angiotensin maturation (GO:0002003)9.96042602
2regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)6.53124728
3vitamin A metabolic process (GO:0006776)6.29023284
4actin filament depolymerization (GO:0030042)6.21731832
5drug catabolic process (GO:0042737)5.84689307
6regulation of bile acid biosynthetic process (GO:0070857)5.82950745
7flavonoid metabolic process (GO:0009812)5.71610341
8regulation of cellular extravasation (GO:0002691)5.20138521
9digestive system process (GO:0022600)5.17468698
10bundle of His cell to Purkinje myocyte communication (GO:0086069)5.14514235
11adhesion of symbiont to host cell (GO:0044650)5.07820864
12virion attachment to host cell (GO:0019062)5.07820864
13UDP-N-acetylglucosamine metabolic process (GO:0006047)5.03921680
14epoxygenase P450 pathway (GO:0019373)5.02148988
15purine ribonucleoside bisphosphate metabolic process (GO:0034035)5.00159252
163-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)5.00159252
17fat-soluble vitamin biosynthetic process (GO:0042362)4.83539398
18hormone catabolic process (GO:0042447)4.73610741
19modified amino acid transport (GO:0072337)4.73269522
20glucose 6-phosphate metabolic process (GO:0051156)4.72787882
21antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.68321254
22bile acid and bile salt transport (GO:0015721)4.65270268
23maintenance of gastrointestinal epithelium (GO:0030277)4.63321091
24cellular response to hepatocyte growth factor stimulus (GO:0035729)4.59188723
25response to hepatocyte growth factor (GO:0035728)4.59188723
26positive regulation of guanylate cyclase activity (GO:0031284)4.58668406
27antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.58513325
28sulfate transmembrane transport (GO:1902358)4.52627685
29phospholipid efflux (GO:0033700)4.44223056
30antigen processing and presentation of endogenous antigen (GO:0019883)4.42115304
31intestinal epithelial cell development (GO:0060576)4.35095318
32lipoprotein metabolic process (GO:0042157)4.34922614
33digestion (GO:0007586)4.33963362
34triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.32546192
35plasma lipoprotein particle assembly (GO:0034377)4.23888993
36positive regulation of lipoprotein lipase activity (GO:0051006)4.22374287
37positive regulation of triglyceride lipase activity (GO:0061365)4.22374287
38peptide catabolic process (GO:0043171)4.20736398
39oligosaccharide catabolic process (GO:0009313)4.18133173
40regulation of triglyceride catabolic process (GO:0010896)4.17807026
41lipoprotein transport (GO:0042953)4.11463602
42sulfur compound transport (GO:0072348)4.11068888
43protein-lipid complex assembly (GO:0065005)4.07410306
44drug transmembrane transport (GO:0006855)4.05611509
45negative regulation of myotube differentiation (GO:0010832)4.05207546
46urea cycle (GO:0000050)4.04127088
47adhesion of symbiont to host (GO:0044406)4.02533813
48regulation of cholesterol esterification (GO:0010872)4.00673514
49drug transport (GO:0015893)3.99987622
50positive regulation of respiratory burst (GO:0060267)3.99854023
51regulation of vitamin metabolic process (GO:0030656)3.99791954
52peptide hormone processing (GO:0016486)3.92154688
53bicarbonate transport (GO:0015701)3.88316345
54very-low-density lipoprotein particle assembly (GO:0034379)3.84722132
55regulation of cholesterol homeostasis (GO:2000188)3.84051145
56urea metabolic process (GO:0019627)3.82083378
57cholesterol homeostasis (GO:0042632)3.80386030
58exogenous drug catabolic process (GO:0042738)3.79777499
59regulation of cGMP biosynthetic process (GO:0030826)3.79105179
60sterol homeostasis (GO:0055092)3.78725166
61renal system process involved in regulation of blood volume (GO:0001977)3.75471025
62sulfate transport (GO:0008272)3.67707386
63negative regulation of cholesterol transport (GO:0032375)3.66867271
64negative regulation of sterol transport (GO:0032372)3.66867271
65cholesterol efflux (GO:0033344)3.61893873
66positive regulation of Cdc42 GTPase activity (GO:0043089)3.59176186
67transepithelial transport (GO:0070633)3.58865135
68epithelial structure maintenance (GO:0010669)3.58413865
69positive regulation of pseudopodium assembly (GO:0031274)3.55182739
70cellular glucuronidation (GO:0052695)3.52159098
71O-glycan processing (GO:0016266)3.51370236
72nitrogen cycle metabolic process (GO:0071941)3.50890935
73diacylglycerol metabolic process (GO:0046339)3.50442760
74striated muscle atrophy (GO:0014891)3.48206236
75transcytosis (GO:0045056)3.45007831
76glucuronate metabolic process (GO:0019585)3.43021463
77uronic acid metabolic process (GO:0006063)3.43021463
78glomerular filtration (GO:0003094)3.41215147
79sperm capacitation (GO:0048240)3.41043811
80glycosphingolipid catabolic process (GO:0046479)3.39299807
81glycolipid catabolic process (GO:0019377)3.36350882
82sulfation (GO:0051923)3.35097193
83sterol transport (GO:0015918)3.31922292
84cholesterol transport (GO:0030301)3.31922292
85regulation of systemic arterial blood pressure by hormone (GO:0001990)3.28311974
86regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.28311974
87endocrine process (GO:0050886)3.28311974
88antibacterial humoral response (GO:0019731)3.26870714
89drinking behavior (GO:0042756)3.23661932
90antimicrobial humoral response (GO:0019730)3.23460336
91desmosome organization (GO:0002934)3.22971352
92renal absorption (GO:0070293)3.22406581
93NADH metabolic process (GO:0006734)3.21827065
94cellular response to reactive nitrogen species (GO:1902170)3.20576989
95receptor guanylyl cyclase signaling pathway (GO:0007168)3.18767837
96cellular response to nitric oxide (GO:0071732)3.18377762
97regulation of pseudopodium assembly (GO:0031272)3.17982805
98regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.17269291
99auditory receptor cell differentiation (GO:0042491)3.15257882
100phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.13470881
101cellular carbohydrate catabolic process (GO:0044275)3.12619255
102response to nitric oxide (GO:0071731)3.12191171
103alkaloid metabolic process (GO:0009820)3.11067241
104cGMP-mediated signaling (GO:0019934)3.10630492
105calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.10153124
106sexual reproduction (GO:0019953)3.09845783
107regulation of actin nucleation (GO:0051125)3.08116220
108positive regulation of fatty acid biosynthetic process (GO:0045723)3.07720134
109renal filtration (GO:0097205)3.07689078
110drug metabolic process (GO:0017144)3.07688518
111regulation of dendritic cell antigen processing and presentation (GO:0002604)3.06988151
112negative regulation of digestive system process (GO:0060457)3.06752741
113sphingomyelin metabolic process (GO:0006684)3.04851260
114thrombin receptor signaling pathway (GO:0070493)3.03185630
115regulation of cGMP metabolic process (GO:0030823)3.02485988
116skeletal muscle adaptation (GO:0043501)3.01142449
117vitamin transmembrane transport (GO:0035461)3.01104192
118hemidesmosome assembly (GO:0031581)3.00618633
119ethanol oxidation (GO:0006069)3.00071404
120regulation of respiratory burst (GO:0060263)2.99755468
121nucleoside diphosphate biosynthetic process (GO:0009133)2.99397783
122cytidine deamination (GO:0009972)2.97493445
123cytidine metabolic process (GO:0046087)2.97493445
124cytidine catabolic process (GO:0006216)2.97493445
125response to hydroperoxide (GO:0033194)2.95582833
126regulation of digestive system process (GO:0044058)2.94980486
127membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.93946545
128positive regulation of lipid catabolic process (GO:0050996)2.93834907
129regulation of systemic arterial blood pressure (GO:0003073)2.93546947
130thyroid hormone metabolic process (GO:0042403)2.91229043
131antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.89069467
132leukotriene metabolic process (GO:0006691)2.88841908
133homocysteine metabolic process (GO:0050667)2.88603826
134muscle atrophy (GO:0014889)2.87518857
135positive regulation of glycoprotein biosynthetic process (GO:0010560)2.85608430
136regulation of guanylate cyclase activity (GO:0031282)2.81106829
137reverse cholesterol transport (GO:0043691)2.80921732
138glutamine family amino acid biosynthetic process (GO:0009084)2.80545924
139fructose metabolic process (GO:0006000)2.80540291
140phospholipid scrambling (GO:0017121)2.79528100
141negative regulation of keratinocyte proliferation (GO:0010839)2.79115499
142complement activation, classical pathway (GO:0006958)2.78925771
143nucleobase catabolic process (GO:0046113)2.76972254
144fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.76474462
145midgut development (GO:0007494)2.75287196
146arginine metabolic process (GO:0006525)2.73991830
147ceramide catabolic process (GO:0046514)2.67002796
148positive regulation of fatty acid beta-oxidation (GO:0032000)2.65342288
149positive regulation of glycoprotein metabolic process (GO:1903020)2.61758381
150renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.59649098
151GDP-mannose metabolic process (GO:0019673)2.56781958
152dendritic cell chemotaxis (GO:0002407)2.56673576
153intestinal absorption (GO:0050892)11.0523727
154intestinal cholesterol absorption (GO:0030299)10.2811210

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.68708722
2CDX2_20551321_ChIP-Seq_CACO-2_Human5.65155474
3SOX2_27498859_Chip-Seq_STOMACH_Mouse3.85781351
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.58756128
5HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.15731298
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.11025169
7GATA4_25053715_ChIP-Seq_YYC3_Human3.06944344
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.92306920
9GATA6_25053715_ChIP-Seq_YYC3_Human2.89848338
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.69801722
11SOX2_20726797_ChIP-Seq_SW620_Human2.69644462
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.63164360
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.58477294
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.56732760
15CDX2_19796622_ChIP-Seq_MESCs_Mouse2.51834873
16VDR_21846776_ChIP-Seq_THP-1_Human2.22988011
17PPAR_26484153_Chip-Seq_NCI-H1993_Human2.10455222
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.02880530
19SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.01205200
20SRY_22984422_ChIP-ChIP_TESTIS_Rat1.98780777
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.97563570
22CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.96664309
23PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.96041624
24VDR_24763502_ChIP-Seq_THP-1_Human1.94988527
25KLF5_25053715_ChIP-Seq_YYC3_Human1.81565551
26ESR2_21235772_ChIP-Seq_MCF-7_Human1.80590344
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.78171366
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.74900183
29CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.72275923
30RUNX1_27514584_Chip-Seq_MCF-7_Human1.67349282
31TCF4_18268006_ChIP-ChIP_LS174T_Human1.66998595
32RUNX_20019798_ChIP-Seq_JUKART_Human1.65572966
33TCF7_22412390_ChIP-Seq_EML_Mouse1.63351964
34FOXO3_23340844_ChIP-Seq_DLD1_Human1.60714927
35KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.59986995
36ESR1_21235772_ChIP-Seq_MCF-7_Human1.59217602
37MYC_22102868_ChIP-Seq_BL_Human1.59065946
38IRF8_21731497_ChIP-ChIP_J774_Mouse1.58932994
39UTX_26944678_Chip-Seq_JUKART_Human1.58648789
40E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.57992416
41EGR1_23403033_ChIP-Seq_LIVER_Mouse1.57892896
42KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.56647300
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.56407378
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56104952
45* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.55353264
46RACK7_27058665_Chip-Seq_MCF-7_Human1.52811916
47KDM2B_26808549_Chip-Seq_SUP-B15_Human1.52632615
48ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.49597631
49NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49361074
50FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.48576518
51SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48295024
52NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.47206518
53ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.45430160
54STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.44688073
55ELK3_25401928_ChIP-Seq_HUVEC_Human1.43481676
56RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.42569984
57ATF3_27146783_Chip-Seq_COLON_Human1.42409757
58KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.41779167
59MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.39702976
60* HNF4A_19822575_ChIP-Seq_HepG2_Human1.37554383
61NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34757365
62BCL6_27268052_Chip-Seq_Bcells_Human1.31907507
63GATA2_19941826_ChIP-Seq_K562_Human1.31702934
64BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.31273003
65GATA1_22383799_ChIP-Seq_G1ME_Mouse1.31193206
66BCOR_27268052_Chip-Seq_Bcells_Human1.31085353
67GATA2_22383799_ChIP-Seq_G1ME_Mouse1.30334765
68TET1_21451524_ChIP-Seq_MESCs_Mouse1.29387636
69FOXA2_19822575_ChIP-Seq_HepG2_Human1.28129238
70CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27928412
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27197747
72RARG_19884340_ChIP-ChIP_MEFs_Mouse1.26731181
73KDM2B_26808549_Chip-Seq_DND41_Human1.24686421
74FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.23818368
75* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.23380149
76RUNX1_22412390_ChIP-Seq_EML_Mouse1.22872935
77MYB_26560356_Chip-Seq_TH2_Human1.22610343
78CLOCK_20551151_ChIP-Seq_293T_Human1.22342789
79IRF8_27001747_Chip-Seq_BMDM_Mouse1.21684957
80MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21290814
81STAT6_21828071_ChIP-Seq_BEAS2B_Human1.20802569
82SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.19882136
83AR_21909140_ChIP-Seq_LNCAP_Human1.19114431
84GATA1_19941827_ChIP-Seq_MEL_Mouse1.18544830
85NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.16293920
86NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13894645
87MYB_26560356_Chip-Seq_TH1_Human1.13871613
88ESR1_20079471_ChIP-ChIP_T-47D_Human1.13415483
89CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11819702
90STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.11380534
91MAF_26560356_Chip-Seq_TH1_Human1.10457382
92CREB1_26743006_Chip-Seq_LNCaP_Human1.10140762
93KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09859367
94EGR1_19374776_ChIP-ChIP_THP-1_Human1.09268977
95SCL_19346495_ChIP-Seq_HPC-7_Human1.08901885
96STAT4_19710469_ChIP-ChIP_TH1__Mouse1.08545736
97PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08338239
98MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.07716961
99SA1_27219007_Chip-Seq_Bcells_Human1.07578899
100JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.07537497
101BRD4_27068464_Chip-Seq_AML-cells_Mouse1.07105185
102JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07015510
103GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06936380
104SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06728838
105* SPI1_23127762_ChIP-Seq_K562_Human1.06711602
106AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.06684577
107HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05476102
108CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04734242
109ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.04541742
110CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04423652
111FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.03309315
112* DROSHA_22980978_ChIP-Seq_HELA_Human1.02688882
113SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00573251
114FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99687746
115EGR1_19032775_ChIP-ChIP_M12_Human0.99607851
116GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99605842
117FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.98303092
118PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.97968493
119P68_20966046_ChIP-Seq_HELA_Human0.97853849
120PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.97101256
121SMAD3_21741376_ChIP-Seq_HESCs_Human0.96599287
122VDR_22108803_ChIP-Seq_LS180_Human0.95614899
123GATA1_26923725_Chip-Seq_HPCs_Mouse0.94502897
124SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.94308212
125SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.94308212
126GATA1_22025678_ChIP-Seq_K562_Human0.91619688
127KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.91424519
128GATA3_24758297_ChIP-Seq_MCF-7_Human0.90481839
129LXR_22292898_ChIP-Seq_THP-1_Human0.89121619
130TCF3_18692474_ChIP-Seq_MEFs_Mouse0.88556376
131PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88078698
132FOXM1_26456572_ChIP-Seq_MCF-7_Human0.86259040
133ZNF263_19887448_ChIP-Seq_K562_Human0.86012430
134FOXA1_25552417_ChIP-Seq_VCAP_Human0.85470948
135FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.85059410
136BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.85021045
137SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.84671284
138SOX9_24532713_ChIP-Seq_HFSC_Mouse0.84292736
139SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.81867746
140CDX2_22108803_ChIP-Seq_LS180_Human0.79670241
141GATA1_19941826_ChIP-Seq_K562_Human0.79244464
142P63_26484246_Chip-Seq_KERATINOCYTES_Human0.78282394
143CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.77114097
144TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76211237
145JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75093018
146* CTCF_27219007_Chip-Seq_Bcells_Human0.74484961
147THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.74336207
148TP63_22573176_ChIP-Seq_HFKS_Human0.74154601
149* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.73804099
150GATA2_21666600_ChIP-Seq_HMVEC_Human0.73350538
151TP63_23658742_ChIP-Seq_EP156T_Human0.73316168
152NANOG_20526341_ChIP-Seq_ESCs_Human0.72882947
153TP53_16413492_ChIP-PET_HCT116_Human0.72624773

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.47350916
2MP0001666_abnormal_nutrient_absorption5.60707442
3MP0010234_abnormal_vibrissa_follicle4.72748056
4MP0004264_abnormal_extraembryonic_tissu3.88387243
5MP0002139_abnormal_hepatobiliary_system3.63454477
6MP0005085_abnormal_gallbladder_physiolo3.35238815
7MP0003252_abnormal_bile_duct3.18290946
8MP0000462_abnormal_digestive_system3.16991312
9MP0003866_abnormal_defecation3.14496649
10MP0008875_abnormal_xenobiotic_pharmacok3.13543337
11MP0003878_abnormal_ear_physiology2.92439073
12MP0005377_hearing/vestibular/ear_phenot2.92439073
13MP0009840_abnormal_foam_cell2.89016814
14MP0002822_catalepsy2.85137181
15MP0003183_abnormal_peptide_metabolism2.74434676
16MP0004043_abnormal_pH_regulation2.43062155
17MP0004019_abnormal_vitamin_homeostasis2.38104405
18MP0010329_abnormal_lipoprotein_level2.21624832
19MP0005365_abnormal_bile_salt2.19450412
20MP0005409_darkened_coat_color2.17707600
21MP0003300_gastrointestinal_ulcer2.07674687
22MP0001663_abnormal_digestive_system2.05888354
23MP0005381_digestive/alimentary_phenotyp2.02593228
24MP0000537_abnormal_urethra_morphology2.01889552
25MP0001873_stomach_inflammation2.00060969
26MP0010155_abnormal_intestine_physiology1.99344889
27MP0001664_abnormal_digestion1.89126581
28MP0002396_abnormal_hematopoietic_system1.88825853
29MP0003724_increased_susceptibility_to1.83751050
30MP0005084_abnormal_gallbladder_morpholo1.78203468
31MP0000538_abnormal_urinary_bladder1.78192466
32MP0000477_abnormal_intestine_morphology1.75057112
33MP0004147_increased_porphyrin_level1.72520947
34MP0010352_gastrointestinal_tract_polyps1.64431558
35MP0003283_abnormal_digestive_organ1.62298068
36MP0000490_abnormal_crypts_of1.60925931
37MP0003436_decreased_susceptibility_to1.59946678
38MP0009643_abnormal_urine_homeostasis1.56112976
39MP0005670_abnormal_white_adipose1.55371627
40MP0003705_abnormal_hypodermis_morpholog1.54523306
41MP0003763_abnormal_thymus_physiology1.53821768
42MP0002796_impaired_skin_barrier1.50097418
43MP0003303_peritoneal_inflammation1.48939296
44MP0001835_abnormal_antigen_presentation1.44831527
45MP0005332_abnormal_amino_acid1.39374016
46MP0002166_altered_tumor_susceptibility1.38247885
47MP0002009_preneoplasia1.34014437
48MP0000465_gastrointestinal_hemorrhage1.33235997
49MP0001765_abnormal_ion_homeostasis1.33037836
50MP0005167_abnormal_blood-brain_barrier1.32892458
51MP0003191_abnormal_cellular_cholesterol1.29694421
52MP0005025_abnormal_response_to1.27615582
53MP0005387_immune_system_phenotype1.25709662
54MP0001790_abnormal_immune_system1.25709662
55MP0005666_abnormal_adipose_tissue1.24061226
56MP0000685_abnormal_immune_system1.22111867
57MP0004858_abnormal_nervous_system1.19776617
58MP0002089_abnormal_postnatal_growth/wei1.19519235
59MP0004782_abnormal_surfactant_physiolog1.15749576
60MP0001845_abnormal_inflammatory_respons1.15677343
61MP0009785_altered_susceptibility_to1.15028693
62MP0005448_abnormal_energy_balance1.14681019
63MP0001800_abnormal_humoral_immune1.12659129
64MP0006054_spinal_hemorrhage1.08327187
65MP0010678_abnormal_skin_adnexa1.07297240
66MP0001849_ear_inflammation1.04645622
67MP0005636_abnormal_mineral_homeostasis1.02917198
68MP0009379_abnormal_foot_pigmentation1.02774877
69MP0002254_reproductive_system_inflammat1.01205669
70MP0003806_abnormal_nucleotide_metabolis1.00525895
71MP0005501_abnormal_skin_physiology0.98896579
72MP0002118_abnormal_lipid_homeostasis0.97004234
73MP0000467_abnormal_esophagus_morphology0.95784932
74MP0002971_abnormal_brown_adipose0.95159181
75MP0009780_abnormal_chondrocyte_physiolo0.94472121
76MP0005000_abnormal_immune_tolerance0.93273298
77MP0002136_abnormal_kidney_physiology0.93195726
78MP0009115_abnormal_fat_cell0.92650765
79MP0004185_abnormal_adipocyte_glucose0.91512806
80MP0002098_abnormal_vibrissa_morphology0.90118230
81MP0004947_skin_inflammation0.88944266
82MP0008872_abnormal_physiological_respon0.88601722
83MP0002006_tumorigenesis0.88421166
84MP0005671_abnormal_response_to0.88381779
85MP0009333_abnormal_splenocyte_physiolog0.88056166
86MP0001819_abnormal_immune_cell0.87092630
87MP0000609_abnormal_liver_physiology0.87027402
88MP0002148_abnormal_hypersensitivity_rea0.86909376
89MP0002420_abnormal_adaptive_immunity0.85092294
90MP0003453_abnormal_keratinocyte_physiol0.84899135
91MP0009053_abnormal_anal_canal0.84771973
92MP0002452_abnormal_antigen_presenting0.84242054
93MP0008469_abnormal_protein_level0.84208412
94MP0005166_decreased_susceptibility_to0.83829564
95MP0003315_abnormal_perineum_morphology0.83574019
96MP0002723_abnormal_immune_serum0.82442037
97MP0004381_abnormal_hair_follicle0.80785090
98MP0009384_cardiac_valve_regurgitation0.77904866
99MP0005367_renal/urinary_system_phenotyp0.77690084
100MP0000516_abnormal_urinary_system0.77690084
101MP0005535_abnormal_body_temperature0.77437698
102MP0005058_abnormal_lysosome_morphology0.76872508
103MP0002419_abnormal_innate_immunity0.76063217
104MP0001533_abnormal_skeleton_physiology0.75112789
105MP0005319_abnormal_enzyme/_coenzyme0.74857266
106MP0001188_hyperpigmentation0.73940004
107MP0001756_abnormal_urination0.72233492
108MP0001216_abnormal_epidermal_layer0.70372537
109MP0003879_abnormal_hair_cell0.70248275
110MP0000716_abnormal_immune_system0.70240546
111MP0003045_fibrosis0.69338768
112MP0001764_abnormal_homeostasis0.68987815
113MP0000249_abnormal_blood_vessel0.68757775
114MP0002998_abnormal_bone_remodeling0.67356568
115MP0002876_abnormal_thyroid_physiology0.65194471
116MP0000678_abnormal_parathyroid_gland0.64776539
117MP0003868_abnormal_feces_composition0.63250880
118MP0000470_abnormal_stomach_morphology0.63191999
119MP0005310_abnormal_salivary_gland0.60985236
120MP0004270_analgesia0.59813326
121MP0005266_abnormal_metabolism0.59565573
122MP0002138_abnormal_hepatobiliary_system0.58422165
123MP0005584_abnormal_enzyme/coenzyme_acti0.58071068
124MP0005451_abnormal_body_composition0.57405259
125MP0003941_abnormal_skin_development0.53187135
126MP0009642_abnormal_blood_homeostasis0.50485740
127MP0003718_maternal_effect0.46501896
128MP0003638_abnormal_response/metabolism_0.46083779
129MP0009765_abnormal_xenobiotic_induced0.45351404
130MP0000230_abnormal_systemic_arterial0.43902313
131MP0003950_abnormal_plasma_membrane0.43673068
132MP0002277_abnormal_respiratory_mucosa0.42926959
133MP0002060_abnormal_skin_morphology0.42923906
134MP0008004_abnormal_stomach_pH0.42373204
135MP0005376_homeostasis/metabolism_phenot0.41578510
136MP0000377_abnormal_hair_follicle0.41521769
137MP0001191_abnormal_skin_condition0.41226924
138MP0009697_abnormal_copulation0.40523475
139MP0008961_abnormal_basal_metabolism0.40434981
140MP0008873_increased_physiological_sensi0.40364207
141MP0000613_abnormal_salivary_gland0.39993338
142MP0010771_integument_phenotype0.39470764
143MP0001485_abnormal_pinna_reflex0.37801596
144MP0000383_abnormal_hair_follicle0.35197497

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)8.70521418
2Abnormality of glutamine family amino acid metabolism (HP:0010902)6.42273957
3Malnutrition (HP:0004395)5.86844288
4Acanthocytosis (HP:0001927)5.54303020
5Hypobetalipoproteinemia (HP:0003563)5.32068462
6Right ventricular cardiomyopathy (HP:0011663)5.19944391
7Conjugated hyperbilirubinemia (HP:0002908)5.08418636
8Hydroxyprolinuria (HP:0003080)4.85511996
9Abnormality of proline metabolism (HP:0010907)4.85511996
10Eczematoid dermatitis (HP:0000976)4.37247578
11Widely patent fontanelles and sutures (HP:0004492)4.32375327
12Autoimmune thrombocytopenia (HP:0001973)4.21021790
13Systemic lupus erythematosus (HP:0002725)4.20618605
14Hyperactive renin-angiotensin system (HP:0000841)3.97844816
15Decreased circulating renin level (HP:0003351)3.95806895
16Cupped ribs (HP:0000887)3.88679059
17Hemorrhage of the eye (HP:0011885)3.83577909
18Abdominal distention (HP:0003270)3.81023081
19Fat malabsorption (HP:0002630)3.75822222
20Chronic diarrhea (HP:0002028)3.69642762
21Abnormality of chloride homeostasis (HP:0011422)3.57945990
22Metabolic alkalosis (HP:0200114)3.57738445
23Potter facies (HP:0002009)3.57606703
24Facial shape deformation (HP:0011334)3.57606703
25Dehydration (HP:0001944)3.51879350
26Flat acetabular roof (HP:0003180)3.36465519
27Hyperglycinuria (HP:0003108)3.35455640
28Abnormality of the vitamin B12 metabolism (HP:0004341)3.29214589
29Pigmentary retinal degeneration (HP:0001146)3.28081154
30Pustule (HP:0200039)3.23064629
31Glycosuria (HP:0003076)3.20733715
32Abnormality of urine glucose concentration (HP:0011016)3.20733715
33Poikilocytosis (HP:0004447)3.16894489
34Hypolipoproteinemia (HP:0010981)3.12151372
35Abnormality of small intestinal villus morphology (HP:0011472)3.11618352
36Villous atrophy (HP:0011473)3.11618352
37Autoimmune hemolytic anemia (HP:0001890)3.07569712
38Abnormality of vitamin B metabolism (HP:0004340)3.06290388
39Gastrointestinal dysmotility (HP:0002579)3.05850661
40Abnormal tarsal ossification (HP:0008369)2.97354341
41Abnormality of purine metabolism (HP:0004352)2.91337452
42Abnormality of the 1st metacarpal (HP:0010009)2.84546970
43Congenital sensorineural hearing impairment (HP:0008527)2.84088996
44Intrahepatic cholestasis (HP:0001406)2.83867300
45Progressive sensorineural hearing impairment (HP:0000408)2.71595075
46Wide cranial sutures (HP:0010537)2.70526802
47Mildly elevated creatine phosphokinase (HP:0008180)2.70021012
48Abnormality of monocarboxylic acid metabolism (HP:0010996)2.69448932
49Nephrolithiasis (HP:0000787)2.68126856
50Xanthomatosis (HP:0000991)2.64472004
51Nausea (HP:0002018)2.62207025
52Abnormality of vitamin metabolism (HP:0100508)2.56829775
53Hyperphosphaturia (HP:0003109)2.50778055
54Abnormal biliary tract morphology (HP:0012440)2.49494031
55Gingivitis (HP:0000230)2.46907602
56Proximal tubulopathy (HP:0000114)2.45797227
57Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.43990065
58Abnormality of the gastric mucosa (HP:0004295)2.40796197
59Milia (HP:0001056)2.40481420
60Thin bony cortex (HP:0002753)2.39134215
61Abnormality of complement system (HP:0005339)2.37251285
62Abnormality of B cell number (HP:0010975)2.36955781
63Progressive hearing impairment (HP:0001730)2.32622531
64Abnormality of renin-angiotensin system (HP:0000847)2.31839623
65Rectal prolapse (HP:0002035)2.31078303
66Colitis (HP:0002583)2.30261443
67Confusion (HP:0001289)2.28843837
68Abnormality of glycine metabolism (HP:0010895)2.27078615
69Abnormality of serine family amino acid metabolism (HP:0010894)2.27078615
70Abnormality of carpal bone ossification (HP:0006257)2.26686493
71Syncope (HP:0001279)2.26300640
72Woolly hair (HP:0002224)2.25261305
73Pili torti (HP:0003777)2.24677683
74Hypercholesterolemia (HP:0003124)2.23771282
75Abnormality of aspartate family amino acid metabolism (HP:0010899)2.22191580
76Abnormal urine phosphate concentration (HP:0012599)2.21563402
77Abnormal foot bone ossification (HP:0010675)2.20967324
78Alopecia of scalp (HP:0002293)2.20927772
79Segmental peripheral demyelination/remyelination (HP:0003481)2.19080255
80Mesangial abnormality (HP:0001966)2.18478504
81Hypotension (HP:0002615)2.17817874
82Abnormality of nucleobase metabolism (HP:0010932)2.16766673
83Fragile skin (HP:0001030)2.15895929
84Metabolic acidosis (HP:0001942)2.15857135
85Glomerulonephritis (HP:0000099)2.15575960
86Abnormality of dicarboxylic acid metabolism (HP:0010995)2.14835026
87Dicarboxylic aciduria (HP:0003215)2.14835026
88Inflammation of the large intestine (HP:0002037)2.14192187
89Palpitations (HP:0001962)2.14019948
90Ventricular fibrillation (HP:0001663)2.13415376
91Gastrointestinal inflammation (HP:0004386)2.13247505
92Cerebral palsy (HP:0100021)2.13042292
93Increased mean platelet volume (HP:0011877)2.11913052
94Enlarged epiphyses (HP:0010580)2.10398794
95Complement deficiency (HP:0004431)2.09050899
96Cheilitis (HP:0100825)2.07890718
97Abnormality of pyrimidine metabolism (HP:0004353)2.06947125
98Alkalosis (HP:0001948)2.05609446
99Abnormal glucose tolerance (HP:0001952)2.05247350
100Ureteral stenosis (HP:0000071)2.03609057
101Hypophosphatemia (HP:0002148)2.02737332
102Symptomatic seizures (HP:0011145)1.99495531
103Abnormal urine output (HP:0012590)1.97424490
104Nephritis (HP:0000123)1.97111970
105Petechiae (HP:0000967)1.96966261
106Abnormality of the distal phalanx of the thumb (HP:0009617)1.96819194
107Delayed epiphyseal ossification (HP:0002663)1.96706095
108Posterior subcapsular cataract (HP:0007787)1.95100172
109Abnormality of renal excretion (HP:0011036)1.94721343
110Focal segmental glomerulosclerosis (HP:0000097)1.94561126
111Emphysema (HP:0002097)1.94339591
112Gastrointestinal stroma tumor (HP:0100723)1.93884613
113B lymphocytopenia (HP:0010976)1.93068008
114Growth hormone excess (HP:0000845)1.91582207
115Plantar hyperkeratosis (HP:0007556)1.91484943
116Hyperaldosteronism (HP:0000859)1.91234543
117Abnormality of sulfur amino acid metabolism (HP:0004339)1.90872259
118Increased IgE level (HP:0003212)1.90101178
119Hyperammonemia (HP:0001987)1.89248227
120Short phalanx of the thumb (HP:0009660)1.88425050
121Ureteral obstruction (HP:0006000)1.87813064
122Epidermoid cyst (HP:0200040)1.87638713
123Hyperparathyroidism (HP:0000843)1.85668788
124Recurrent fungal infections (HP:0002841)1.84949674
125Increased purine levels (HP:0004368)1.84734162
126Hyperuricemia (HP:0002149)1.84734162
127Abnormality of macrophages (HP:0004311)1.83471677
128Fragile nails (HP:0001808)1.83343789
129Bone pain (HP:0002653)1.82481857
130Multiple lipomas (HP:0001012)1.81692221
131Steatorrhea (HP:0002570)1.81450975
132Vasculitis (HP:0002633)1.81026544
133Late onset (HP:0003584)1.80432484
134Abnormality of the fingertips (HP:0001211)1.80369651
135Cellulitis (HP:0100658)1.78999641
136Gastrointestinal infarctions (HP:0005244)1.76454503
137Hyperphosphatemia (HP:0002905)1.75735651
138Abnormality of the costochondral junction (HP:0000919)1.75324173
139Spontaneous hematomas (HP:0007420)1.75136189
140Megaloblastic anemia (HP:0001889)1.73891613
141Protuberant abdomen (HP:0001538)1.73292891
142Encephalitis (HP:0002383)1.70999170

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.50400162
2MST1R5.37167999
3MST45.33111772
4LMTK25.14504469
5ACVR1B4.98313103
6PRKG23.28945125
7NME13.24856604
8PIK3CA3.22059669
9RIPK12.84294197
10GRK62.80009990
11PRPF4B2.71609007
12MAP2K22.70018284
13EPHA22.57491901
14NLK2.52488339
15MAP3K22.37006030
16TRIB32.11961295
17TYK22.07755578
18MAP3K102.04230787
19NUAK12.01604296
20EPHB21.96306465
21AKT31.96026179
22EPHA31.93374307
23MET1.85795934
24SMG11.83008815
25PTK61.76140586
26ZAP701.71192623
27WNK41.65290364
28ERN11.38666214
29TESK11.36611031
30FGFR31.32827537
31TAOK11.27265152
32MYLK1.21898722
33DMPK1.20738466
34KSR21.19437089
35STK101.17065268
36OXSR11.14803529
37STK391.09794574
38MAP3K71.05379585
39TAOK31.05259017
40PRKCI1.04392411
41STK241.02296528
42TTK1.00092968
43DDR20.99231604
44PTK20.95116458
45MAP2K60.93678372
46MAP3K80.90925983
47CDK60.89889703
48ERBB20.89074896
49RET0.88218898
50MATK0.87684622
51EPHB10.86236930
52SYK0.83362432
53MAP2K10.82613963
54MAP3K140.81354280
55JAK10.80825875
56BLK0.80290842
57PRKAA20.79174228
58RIPK40.77744403
59IRAK10.77405030
60TBK10.74007274
61LATS10.70556136
62MAP3K10.69632540
63IRAK40.69161219
64FER0.68933679
65BTK0.68685781
66JAK20.67181824
67HIPK20.66553259
68PBK0.65434680
69TESK20.64499059
70PDGFRA0.64320671
71MAP3K110.63788792
72PAK40.63698802
73JAK30.59952821
74BMX0.59483863
75PDPK10.59480914
76PKN20.57218997
77SIK10.55249454
78MAPK110.54094763
79LCK0.53462190
80MARK20.52425683
81CAMK2D0.51976518
82LYN0.51948493
83FES0.51481479
84LRRK20.48554422
85CDK40.48511518
86EEF2K0.47251388
87MAP3K130.47076640
88WNK30.44723206
89PRKAA10.44071787
90PDK20.43422292
91KDR0.42371618
92PRKCZ0.42187618
93MAP3K30.41350532
94HCK0.40521627
95MAP3K90.38746674
96ICK0.37784394
97CDK120.37144601
98DYRK1B0.37068335
99PDK10.35739391
100CSK0.35028121
101ROCK10.34990901
102RPS6KC10.34442342
103RPS6KL10.34442342
104MELK0.34307445
105PRKCA0.34214453
106MAP2K30.33751061
107AURKB0.33150079
108MAPK70.32751586
109STK38L0.32309044
110GRK10.30624206
111TYRO30.30105591
112TAOK20.29734066
113MAPK120.29493284
114KIT0.29173173
115SRC0.28049025
116CSF1R0.28007350
117STK110.26544472
118SCYL20.25888825
119PDK30.25716263
120PDK40.25716263
121PAK30.24972654
122CSNK1A10.24172509
123PRKACG0.22786928
124WNK10.22729847
125PAK20.22168508
126LIMK10.22118214
127MAPK150.21228805
128PAK10.21101223
129GSK3A0.20102172
130MAP3K120.19322402
131CAMK2G0.19137180
132MAPKAPK20.17937956
133CDK90.17903933
134AKT20.17677968
135PRKCQ0.17505485
136CAMK2B0.14774906
137FYN0.14254786
138FGFR40.14063981
139MAP4K10.13975633
140ERBB40.12618736
141ITK0.12063053
142PRKCD0.11774783
143IKBKE0.10689865
144CDC42BPA0.10389074
145STK30.09922005

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049755.18698966
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.77620291
3Renin-angiotensin system_Homo sapiens_hsa046144.11235902
4Mineral absorption_Homo sapiens_hsa049784.09779873
5Vitamin digestion and absorption_Homo sapiens_hsa049773.53763562
6Sulfur metabolism_Homo sapiens_hsa009203.26953371
7Galactose metabolism_Homo sapiens_hsa000522.95127258
8Caffeine metabolism_Homo sapiens_hsa002322.73685894
9Carbohydrate digestion and absorption_Homo sapiens_hsa049732.61627008
10Starch and sucrose metabolism_Homo sapiens_hsa005002.55532229
11Bile secretion_Homo sapiens_hsa049762.42364251
12Protein digestion and absorption_Homo sapiens_hsa049742.21149487
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.17997632
14Maturity onset diabetes of the young_Homo sapiens_hsa049502.12819429
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.08165093
16Folate biosynthesis_Homo sapiens_hsa007901.99275768
17Fructose and mannose metabolism_Homo sapiens_hsa000511.91878018
18Histidine metabolism_Homo sapiens_hsa003401.83933257
19Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.57745600
20Cyanoamino acid metabolism_Homo sapiens_hsa004601.53713477
21Tryptophan metabolism_Homo sapiens_hsa003801.45069574
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.43605892
23Asthma_Homo sapiens_hsa053101.37794071
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.37536314
25PPAR signaling pathway_Homo sapiens_hsa033201.36241619
26Glutathione metabolism_Homo sapiens_hsa004801.31502140
27Glycerolipid metabolism_Homo sapiens_hsa005611.31436167
28Allograft rejection_Homo sapiens_hsa053301.27708168
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.21294131
30Autoimmune thyroid disease_Homo sapiens_hsa053201.20418115
31Staphylococcus aureus infection_Homo sapiens_hsa051501.20403827
32Fatty acid degradation_Homo sapiens_hsa000711.18030945
33Sphingolipid metabolism_Homo sapiens_hsa006001.14785680
34Graft-versus-host disease_Homo sapiens_hsa053321.12589942
35Nitrogen metabolism_Homo sapiens_hsa009101.11071616
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.05021455
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.04500801
38Arginine biosynthesis_Homo sapiens_hsa002200.99749629
39Other glycan degradation_Homo sapiens_hsa005110.98985815
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97566095
41Arginine and proline metabolism_Homo sapiens_hsa003300.94807283
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93226041
43Primary immunodeficiency_Homo sapiens_hsa053400.92639354
44ABC transporters_Homo sapiens_hsa020100.91866232
45Leishmaniasis_Homo sapiens_hsa051400.91545176
46Butanoate metabolism_Homo sapiens_hsa006500.91147358
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90116386
48Pyruvate metabolism_Homo sapiens_hsa006200.89496956
49Tight junction_Homo sapiens_hsa045300.86364199
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84291336
51Type I diabetes mellitus_Homo sapiens_hsa049400.78549365
52Carbon metabolism_Homo sapiens_hsa012000.74788388
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72086778
54beta-Alanine metabolism_Homo sapiens_hsa004100.70453575
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67680787
56Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66877651
57Pancreatic secretion_Homo sapiens_hsa049720.66166226
58Hematopoietic cell lineage_Homo sapiens_hsa046400.65950413
59Thyroid hormone synthesis_Homo sapiens_hsa049180.65718579
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64344749
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63555494
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63030542
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.62361721
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62077286
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62044056
66Antigen processing and presentation_Homo sapiens_hsa046120.60009495
67Glycerophospholipid metabolism_Homo sapiens_hsa005640.58425448
68Chemical carcinogenesis_Homo sapiens_hsa052040.55217848
69Pentose phosphate pathway_Homo sapiens_hsa000300.54715309
70Viral myocarditis_Homo sapiens_hsa054160.54578146
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53983896
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.52796984
73Acute myeloid leukemia_Homo sapiens_hsa052210.51319974
74Gastric acid secretion_Homo sapiens_hsa049710.49415266
75Retinol metabolism_Homo sapiens_hsa008300.48691343
76Toxoplasmosis_Homo sapiens_hsa051450.48524342
77Pertussis_Homo sapiens_hsa051330.47428808
78Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46487346
79Peroxisome_Homo sapiens_hsa041460.46275831
80Salmonella infection_Homo sapiens_hsa051320.44359357
81Influenza A_Homo sapiens_hsa051640.44279888
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.43671944
83Sulfur relay system_Homo sapiens_hsa041220.42934082
84Fatty acid metabolism_Homo sapiens_hsa012120.42041105
85Bladder cancer_Homo sapiens_hsa052190.41755971
86Adherens junction_Homo sapiens_hsa045200.41638071
87Intestinal immune network for IgA production_Homo sapiens_hsa046720.41143840
88B cell receptor signaling pathway_Homo sapiens_hsa046620.39351668
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37360913
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.36884440
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.36836508
92Chronic myeloid leukemia_Homo sapiens_hsa052200.35473777
93Arachidonic acid metabolism_Homo sapiens_hsa005900.34561944
94Linoleic acid metabolism_Homo sapiens_hsa005910.34454397
95Tuberculosis_Homo sapiens_hsa051520.33789282
96Lysine degradation_Homo sapiens_hsa003100.33779395
97Notch signaling pathway_Homo sapiens_hsa043300.33619937
98Type II diabetes mellitus_Homo sapiens_hsa049300.33509614
99Salivary secretion_Homo sapiens_hsa049700.33478662
100Thyroid cancer_Homo sapiens_hsa052160.32884291
101Metabolic pathways_Homo sapiens_hsa011000.31479522
102Dorso-ventral axis formation_Homo sapiens_hsa043200.30479691
103Osteoclast differentiation_Homo sapiens_hsa043800.30436336
104Hepatitis C_Homo sapiens_hsa051600.30426394
105Chemokine signaling pathway_Homo sapiens_hsa040620.30311408
106Selenocompound metabolism_Homo sapiens_hsa004500.30308687
107Propanoate metabolism_Homo sapiens_hsa006400.28437181
108Herpes simplex infection_Homo sapiens_hsa051680.28367524
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.27752453
110T cell receptor signaling pathway_Homo sapiens_hsa046600.27656046
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26721663
112Non-small cell lung cancer_Homo sapiens_hsa052230.26512308
113TNF signaling pathway_Homo sapiens_hsa046680.25833663
114African trypanosomiasis_Homo sapiens_hsa051430.24869087
115Amoebiasis_Homo sapiens_hsa051460.21168149
116Pancreatic cancer_Homo sapiens_hsa052120.20744871
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20598371
118Biosynthesis of amino acids_Homo sapiens_hsa012300.19310580
119Phenylalanine metabolism_Homo sapiens_hsa003600.18236579
120Steroid biosynthesis_Homo sapiens_hsa001000.17328020
121Alzheimers disease_Homo sapiens_hsa050100.15678799
122Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.14950306
123Vibrio cholerae infection_Homo sapiens_hsa051100.13790172
124Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.11354481
125Renin secretion_Homo sapiens_hsa049240.10807735
126Ether lipid metabolism_Homo sapiens_hsa005650.10585505
127Insulin secretion_Homo sapiens_hsa049110.10425482
128Phosphatidylinositol signaling system_Homo sapiens_hsa040700.09649355
129Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.08906038
130Choline metabolism in cancer_Homo sapiens_hsa052310.06390019
131Insulin resistance_Homo sapiens_hsa049310.06158402
132Inositol phosphate metabolism_Homo sapiens_hsa005620.05451714
133GnRH signaling pathway_Homo sapiens_hsa049120.05312536
134Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.04730283
135Oxidative phosphorylation_Homo sapiens_hsa001900.03830037
136Central carbon metabolism in cancer_Homo sapiens_hsa052300.02298298
137Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.01452964

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