MYO1C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. The mouse ortholog of this protein also functions in intracellular vesicle transport to the plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. The related gene myosin IE has been referred to as myosin IC in the literature, but it is a distinct locus on chromosome 19. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1low-density lipoprotein particle clearance (GO:0034383)4.36573556
2cell adhesion mediated by integrin (GO:0033627)4.24784316
3apoptotic cell clearance (GO:0043277)3.99142811
4desmosome organization (GO:0002934)3.98465690
5wound healing, spreading of epidermal cells (GO:0035313)3.97796939
6negative regulation of fatty acid transport (GO:2000192)3.82680355
7endodermal cell differentiation (GO:0035987)3.75040646
8protein heterotrimerization (GO:0070208)3.73394470
9barbed-end actin filament capping (GO:0051016)3.70918069
10basement membrane organization (GO:0071711)3.70277550
11plasma membrane repair (GO:0001778)3.68325950
12epithelial cell-cell adhesion (GO:0090136)3.63508000
13collagen fibril organization (GO:0030199)3.58719675
14cell-substrate junction assembly (GO:0007044)3.58096937
15skin morphogenesis (GO:0043589)3.54462021
16retina vasculature morphogenesis in camera-type eye (GO:0061299)3.52730581
17hemidesmosome assembly (GO:0031581)3.34554407
18positive regulation of endothelial cell apoptotic process (GO:2000353)3.32670258
19glomerular visceral epithelial cell development (GO:0072015)3.30900960
20protein retention in ER lumen (GO:0006621)3.27701993
21chondrocyte proliferation (GO:0035988)3.26979866
22maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.23893864
23* vascular endothelial growth factor signaling pathway (GO:0038084)3.22179857
24planar cell polarity pathway involved in neural tube closure (GO:0090179)3.21459587
25cytoskeletal anchoring at plasma membrane (GO:0007016)3.19544860
26wound healing, spreading of cells (GO:0044319)3.13425231
27dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.09267727
28positive regulation of blood vessel endothelial cell migration (GO:0043536)3.07702528
29retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.04317353
30regulation of early endosome to late endosome transport (GO:2000641)3.04187477
31cell migration involved in heart development (GO:0060973)3.03176769
32semaphorin-plexin signaling pathway (GO:0071526)3.01550343
33positive regulation of histone deacetylation (GO:0031065)3.00923729
34atrioventricular valve morphogenesis (GO:0003181)3.00793273
35stress fiber assembly (GO:0043149)3.00341325
36protein localization to endosome (GO:0036010)3.00133767
37regulation of cholesterol storage (GO:0010885)2.99620997
38regulation of hippo signaling (GO:0035330)2.99291441
39glomerular basement membrane development (GO:0032836)2.97333029
40positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.97113750
41regulation of glucose import in response to insulin stimulus (GO:2001273)2.96795195
42adhesion of symbiont to host (GO:0044406)2.95296845
43type B pancreatic cell proliferation (GO:0044342)2.94678104
44extracellular fibril organization (GO:0043206)2.94226777
45morphogenesis of an endothelium (GO:0003159)2.93992847
46endothelial tube morphogenesis (GO:0061154)2.93992847
47renal filtration (GO:0097205)2.93935902
48cell migration involved in sprouting angiogenesis (GO:0002042)2.93634243
49regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.93585599
50adherens junction assembly (GO:0034333)2.92762296
51virion attachment to host cell (GO:0019062)2.92445291
52adhesion of symbiont to host cell (GO:0044650)2.92445291
53positive regulation of p38MAPK cascade (GO:1900745)2.90436073
54endothelial cell chemotaxis (GO:0035767)2.87942683
55positive regulation of receptor recycling (GO:0001921)2.87122967
56glomerular epithelial cell development (GO:0072310)2.84234558
57fibroblast migration (GO:0010761)2.81959327
58response to laminar fluid shear stress (GO:0034616)2.81478421
59extracellular matrix assembly (GO:0085029)2.80679549
60growth hormone receptor signaling pathway (GO:0060396)2.80524600
61cellular response to interferon-alpha (GO:0035457)2.78909494
62neuron projection extension involved in neuron projection guidance (GO:1902284)2.77300354
63axon extension involved in axon guidance (GO:0048846)2.77300354
64membrane raft organization (GO:0031579)2.75869013
65blood vessel endothelial cell migration (GO:0043534)2.75803430
66substrate-dependent cell migration (GO:0006929)2.73929023
67positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.73407946
68response to fluid shear stress (GO:0034405)2.73344083
69substrate adhesion-dependent cell spreading (GO:0034446)2.71628822
70hippo signaling (GO:0035329)2.71171209
71negative regulation of chondrocyte differentiation (GO:0032331)2.70077370
72fibril organization (GO:0097435)2.66891029
73kidney mesenchyme development (GO:0072074)2.66682343
74lymph vessel development (GO:0001945)2.66283858
75antigen processing and presentation of endogenous antigen (GO:0019883)2.65596459
76negative regulation of smooth muscle cell migration (GO:0014912)2.64733719
77regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.64595624
78regulation of SMAD protein import into nucleus (GO:0060390)2.64567805
79endothelial cell morphogenesis (GO:0001886)2.64365229
80cell-substrate adherens junction assembly (GO:0007045)2.63733241
81focal adhesion assembly (GO:0048041)2.63733241
82cellular response to vitamin (GO:0071295)2.62450887
83actin filament depolymerization (GO:0030042)2.61688767
84collagen metabolic process (GO:0032963)2.61076245
85antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.59554988
86antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.59554988
87positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.56917747
88negative regulation of cell size (GO:0045792)2.56101419
89* cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.56093208
90sequestering of extracellular ligand from receptor (GO:0035581)2.55430098
91* regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.54852005
92positive regulation of osteoblast proliferation (GO:0033690)2.53673200
93NADH metabolic process (GO:0006734)2.53295205
94hypotonic response (GO:0006971)2.53169308
95regulation of integrin activation (GO:0033623)2.53129827
96actin filament bundle organization (GO:0061572)2.52467987
97actin filament bundle assembly (GO:0051017)2.52467987
98multicellular organismal macromolecule metabolic process (GO:0044259)2.52384473
99regulation of extracellular matrix disassembly (GO:0010715)2.52005989
100activation of Rac GTPase activity (GO:0032863)2.51719894
101branching involved in mammary gland duct morphogenesis (GO:0060444)2.51461995
102endocytic recycling (GO:0032456)2.50535068
103muscle cell migration (GO:0014812)2.50148036
104collagen catabolic process (GO:0030574)2.50061683
105regulation of apoptotic process involved in morphogenesis (GO:1902337)2.48841476
106extracellular matrix disassembly (GO:0022617)2.48520563
107hyaluronan catabolic process (GO:0030214)2.48108443
108sarcomere organization (GO:0045214)2.46655078
109regulation of fatty acid beta-oxidation (GO:0031998)2.45054642
110germ cell migration (GO:0008354)2.44668623
111positive regulation of Cdc42 GTPase activity (GO:0043089)2.44662250
112glomerular filtration (GO:0003094)2.44323873
113mRNA transcription (GO:0009299)2.44172053
114regulation of p38MAPK cascade (GO:1900744)2.44155364
115mesodermal cell differentiation (GO:0048333)2.43751448
116cellular response to growth hormone stimulus (GO:0071378)2.43013141
117cell junction assembly (GO:0034329)2.42997357
118regulation of macrophage cytokine production (GO:0010935)2.42279094
119positive regulation of SMAD protein import into nucleus (GO:0060391)2.42087406
120positive regulation of natural killer cell differentiation (GO:0032825)2.41112521
121bundle of His cell to Purkinje myocyte communication (GO:0086069)2.40927109
122multicellular organismal metabolic process (GO:0044236)2.40843160
123insulin-like growth factor receptor signaling pathway (GO:0048009)2.40345127
124bone trabecula formation (GO:0060346)2.39664268
125positive regulation of cell adhesion mediated by integrin (GO:0033630)2.38174188
126establishment of endothelial barrier (GO:0061028)2.37922185
127cortical actin cytoskeleton organization (GO:0030866)2.37793197
128gap junction assembly (GO:0016264)2.37530928
129regulation of integrin-mediated signaling pathway (GO:2001044)2.37092531
130multicellular organismal catabolic process (GO:0044243)2.36004846
131positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.35964057
132negative regulation of cartilage development (GO:0061037)2.35537213
133protein hydroxylation (GO:0018126)2.33952759
134vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.33805533
135platelet aggregation (GO:0070527)2.33392036
136COPI coating of Golgi vesicle (GO:0048205)2.31714165
137Golgi transport vesicle coating (GO:0048200)2.31714165
138peptidyl-proline hydroxylation (GO:0019511)2.30358379
139endocardial cushion development (GO:0003197)2.30178196
140negative regulation of stress fiber assembly (GO:0051497)2.29754881
141protein localization to cell surface (GO:0034394)2.29732684
142positive regulation of fatty acid beta-oxidation (GO:0032000)2.29363665
143apoptotic process involved in morphogenesis (GO:0060561)2.27788280
144positive regulation of epithelial to mesenchymal transition (GO:0010718)2.27669059
145negative regulation of phagocytosis (GO:0050765)2.26667049
146surfactant homeostasis (GO:0043129)2.26191654
147integrin-mediated signaling pathway (GO:0007229)2.26086231

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.67937649
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.86596780
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.75715179
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.65433970
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.61347588
6CLOCK_20551151_ChIP-Seq_293T_Human3.09331230
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.90179382
8* ELK3_25401928_ChIP-Seq_HUVEC_Human2.35278923
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.33780489
10* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.32912599
11RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.28108210
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.20232862
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.16197980
14MYC_22102868_ChIP-Seq_BL_Human1.97463494
15KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.96248839
16CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.95802782
17HIF1A_21447827_ChIP-Seq_MCF-7_Human1.93308497
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.86032543
19SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.82632112
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.75552672
21* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.74568031
22SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.71911314
23SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.71911314
24* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.71613789
25VDR_21846776_ChIP-Seq_THP-1_Human1.71403452
26ATF3_27146783_Chip-Seq_COLON_Human1.69740863
27PPAR_26484153_Chip-Seq_NCI-H1993_Human1.68730413
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.68445362
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.67779565
30ESR1_21235772_ChIP-Seq_MCF-7_Human1.67262427
31SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.67199249
32TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65028150
33FOXO3_23340844_ChIP-Seq_DLD1_Human1.64069489
34STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.62968193
35FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.59571706
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.56006194
37RACK7_27058665_Chip-Seq_MCF-7_Human1.55543234
38FOXM1_23109430_ChIP-Seq_U2OS_Human1.54679779
39TBX20_22328084_ChIP-Seq_HEART_Mouse1.51616006
40TBX20_22080862_ChIP-Seq_HEART_Mouse1.51616006
41* GATA2_21666600_ChIP-Seq_HMVEC_Human1.50506626
42ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.48623765
43* KDM2B_26808549_Chip-Seq_DND41_Human1.47881451
44* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.47690245
45* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.46914772
46* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.45662643
47* TCF7_22412390_ChIP-Seq_EML_Mouse1.44988316
48* KDM2B_26808549_Chip-Seq_K562_Human1.43903128
49ZNF263_19887448_ChIP-Seq_K562_Human1.43341275
50CJUN_26792858_Chip-Seq_BT549_Human1.42667887
51KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.40826148
52* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40518686
53BRD4_25478319_ChIP-Seq_HGPS_Human1.40259118
54ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.39681003
55* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.37542955
56PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.36322957
57MAF_26560356_Chip-Seq_TH1_Human1.36210863
58ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.35016380
59ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.34517954
60* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34077136
61PPARA_22158963_ChIP-Seq_LIVER_Mouse1.33765039
62JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30975588
63FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.28949735
64STAT3_1855785_ChIP-Seq_MESCs_Mouse1.27954560
65FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.27614517
66SOX2_27498859_Chip-Seq_STOMACH_Mouse1.26753989
67LXR_22292898_ChIP-Seq_THP-1_Human1.26743414
68ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.26241759
69UBF1/2_26484160_Chip-Seq_HMECs_Human1.25785817
70SOX9_24532713_ChIP-Seq_HFSC_Mouse1.25635537
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25345907
72SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23564487
73TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.23509261
74* IRF8_27001747_Chip-Seq_BMDM_Mouse1.23331896
75ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23044151
76NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.20305962
77SMC1_22415368_ChIP-Seq_MEFs_Mouse1.19329932
78P63_26484246_Chip-Seq_KERATINOCYTES_Human1.19049998
79UTX_26944678_Chip-Seq_JUKART_Human1.18866884
80EP300_21415370_ChIP-Seq_HL-1_Mouse1.18680730
81NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.18299610
82* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.17995112
83VDR_24763502_ChIP-Seq_THP-1_Human1.17498235
84* TET1_21451524_ChIP-Seq_MESCs_Mouse1.17286982
85SALL4_18804426_ChIP-ChIP_XEN_Mouse1.16051815
86ESR1_20079471_ChIP-ChIP_T-47D_Human1.15317785
87EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.14598754
88* NCOR1_26117541_ChIP-Seq_K562_Human1.14556433
89Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.14018871
90TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13803739
91NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13539086
92NFIB_24661679_ChIP-Seq_LUNG_Mouse1.13100182
93RXR_22158963_ChIP-Seq_LIVER_Mouse1.12621437
94CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.12175560
95IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.12068807
96* IRF8_21731497_ChIP-ChIP_J774_Mouse1.11988037
97JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11561672
98* TP53_22127205_ChIP-Seq_IMR90_Human1.10865583
99LXR_22158963_ChIP-Seq_LIVER_Mouse1.10472241
100* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10310026
101* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10017997
102ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09007132
103ERG_21242973_ChIP-ChIP_JURKAT_Human1.08990174
104* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08405644
105* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.06881405
106SMC3_22415368_ChIP-Seq_MEFs_Mouse1.06803122
107SPI1_23127762_ChIP-Seq_K562_Human1.06026968
108FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.06011067
109NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05004572
110STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04712832
111THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04568612
112RUNX1_27514584_Chip-Seq_MCF-7_Human1.04187853
113CDX2_20551321_ChIP-Seq_CACO-2_Human1.04168225
114SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03646934
115E2F7_22180533_ChIP-Seq_HELA_Human1.03638372
116HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03291426
117TP53_23651856_ChIP-Seq_MEFs_Mouse1.02927293
118KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02858531
119* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01698422
120* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.01585707
121* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01277408
122* TET1_21490601_ChIP-Seq_MESCs_Mouse1.01034107
123* SOX2_20726797_ChIP-Seq_SW620_Human1.01024980
124GATA1_22025678_ChIP-Seq_K562_Human0.99872525
125GATA6_25053715_ChIP-Seq_YYC3_Human0.99049890
126AR_21909140_ChIP-Seq_LNCAP_Human0.96983738
127EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.96955474
128* CREB1_26743006_Chip-Seq_LNCaP_Human0.96188696
129TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95960131
130SMC4_20622854_ChIP-Seq_HELA_Human0.95240022
131DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93610849
132ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93588633
133SA1_27219007_Chip-Seq_ERYTHROID_Human0.93412005
134SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92098860
135SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91915736

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.00393115
2MP0003705_abnormal_hypodermis_morpholog4.19458471
3MP0005275_abnormal_skin_tensile3.37435399
4MP0003566_abnormal_cell_adhesion2.97615712
5MP0003279_aneurysm2.69970927
6MP0010352_gastrointestinal_tract_polyps2.66568694
7MP0004272_abnormal_basement_membrane2.50196774
8MP0001958_emphysema2.49155589
9MP0006054_spinal_hemorrhage2.01070310
10MP0003091_abnormal_cell_migration1.97301095
11MP0005023_abnormal_wound_healing1.91581668
12MP0005623_abnormal_meninges_morphology1.90198814
13MP0005670_abnormal_white_adipose1.88265592
14MP0010368_abnormal_lymphatic_system1.87544430
15MP0004858_abnormal_nervous_system1.85619810
16MP0005503_abnormal_tendon_morphology1.79390591
17MP0003300_gastrointestinal_ulcer1.72343733
18MP0010030_abnormal_orbit_morphology1.68807637
19MP0004084_abnormal_cardiac_muscle1.68234496
20MP0001879_abnormal_lymphatic_vessel1.67913471
21MP0004185_abnormal_adipocyte_glucose1.59743821
22MP0002060_abnormal_skin_morphology1.59698069
23MP0003941_abnormal_skin_development1.58364082
24MP0005409_darkened_coat_color1.58212087
25MP0009780_abnormal_chondrocyte_physiolo1.52006085
26MP0005666_abnormal_adipose_tissue1.51870683
27MP0002877_abnormal_melanocyte_morpholog1.51608036
28MP0000733_abnormal_muscle_development1.48783357
29MP0000767_abnormal_smooth_muscle1.48277760
30MP0000750_abnormal_muscle_regeneration1.46425910
31MP0000013_abnormal_adipose_tissue1.44702307
32MP0005076_abnormal_cell_differentiation1.42976986
33MP0003828_pulmonary_edema1.38160742
34MP0003045_fibrosis1.35829878
35MP0005451_abnormal_body_composition1.35397293
36MP0005375_adipose_tissue_phenotype1.35267097
37MP0003303_peritoneal_inflammation1.34542257
38MP0009384_cardiac_valve_regurgitation1.32069726
39MP0004130_abnormal_muscle_cell1.28993289
40MP0001348_abnormal_lacrimal_gland1.28835268
41MP0004233_abnormal_muscle_weight1.28616404
42MP0000003_abnormal_adipose_tissue1.23624156
43MP0005257_abnormal_intraocular_pressure1.22145083
44MP0004087_abnormal_muscle_fiber1.21162490
45MP0003191_abnormal_cellular_cholesterol1.20402453
46MP0002295_abnormal_pulmonary_circulatio1.20274229
47MP0009278_abnormal_bone_marrow1.19823428
48MP0010630_abnormal_cardiac_muscle1.18502459
49MP0002108_abnormal_muscle_morphology1.17986452
50MP0000762_abnormal_tongue_morphology1.16094166
51MP0000534_abnormal_ureter_morphology1.12208552
52MP0000467_abnormal_esophagus_morphology1.10764633
53MP0001243_abnormal_dermal_layer1.09810854
54MP0002166_altered_tumor_susceptibility1.09646445
55MP0002837_dystrophic_cardiac_calcinosis1.08472009
56MP0005595_abnormal_vascular_smooth1.07708420
57MP0000343_altered_response_to1.05846974
58MP0000537_abnormal_urethra_morphology1.05566804
59MP0006138_congestive_heart_failure1.05015836
60MP0004782_abnormal_surfactant_physiolog1.04845265
61MP0010234_abnormal_vibrissa_follicle1.03895002
62MP0000751_myopathy1.02529126
63MP0005330_cardiomyopathy1.01503605
64MP0002168_other_aberrant_phenotype1.00579538
65MP0002128_abnormal_blood_circulation0.99407942
66MP0003448_altered_tumor_morphology0.98005757
67MP0009053_abnormal_anal_canal0.96400260
68MP0004808_abnormal_hematopoietic_stem0.95225200
69MP0001533_abnormal_skeleton_physiology0.95040413
70MP0002971_abnormal_brown_adipose0.94836682
71MP0000685_abnormal_immune_system0.94823485
72MP0001544_abnormal_cardiovascular_syste0.94764875
73MP0005385_cardiovascular_system_phenoty0.94764875
74MP0001915_intracranial_hemorrhage0.94247650
75MP0008775_abnormal_heart_ventricle0.93895783
76MP0005508_abnormal_skeleton_morphology0.92657907
77MP0000858_altered_metastatic_potential0.92652462
78MP0003453_abnormal_keratinocyte_physiol0.91473806
79MP0004947_skin_inflammation0.91362966
80MP0001614_abnormal_blood_vessel0.91101719
81MP0005360_urolithiasis0.90747583
82MP0002933_joint_inflammation0.90704608
83MP0003436_decreased_susceptibility_to0.89847911
84MP0001661_extended_life_span0.89821725
85MP0001216_abnormal_epidermal_layer0.89152347
86MP0002925_abnormal_cardiovascular_devel0.87761922
87MP0004036_abnormal_muscle_relaxation0.87121081
88MP0003950_abnormal_plasma_membrane0.87056384
89MP0000462_abnormal_digestive_system0.85480180
90MP0000749_muscle_degeneration0.85451794
91MP0005058_abnormal_lysosome_morphology0.84655532
92MP0000249_abnormal_blood_vessel0.83642279
93MP0002896_abnormal_bone_mineralization0.82760522
94MP0010307_abnormal_tumor_latency0.81847017
95MP0005165_increased_susceptibility_to0.81596612
96MP0002998_abnormal_bone_remodeling0.81358306
97MP0001299_abnormal_eye_distance/0.81016082
98MP0009115_abnormal_fat_cell0.79807914
99MP0001790_abnormal_immune_system0.79056514
100MP0005387_immune_system_phenotype0.79056514
101MP0005390_skeleton_phenotype0.78643654
102MP0003942_abnormal_urinary_system0.78245466
103MP0001835_abnormal_antigen_presentation0.77789918
104MP0001542_abnormal_bone_strength0.77312406
105MP0000678_abnormal_parathyroid_gland0.76329243
106MP0001545_abnormal_hematopoietic_system0.76256224
107MP0005397_hematopoietic_system_phenotyp0.76256224
108MP0000759_abnormal_skeletal_muscle0.75431460
109MP0002972_abnormal_cardiac_muscle0.75215955
110MP0001881_abnormal_mammary_gland0.75168130
111MP0010771_integument_phenotype0.74794867
112MP0009840_abnormal_foam_cell0.74791810
113MP0002006_tumorigenesis0.74734490
114MP0002796_impaired_skin_barrier0.74531747
115MP0002970_abnormal_white_adipose0.73907378
116MP0000266_abnormal_heart_morphology0.73885652
117MP0003385_abnormal_body_wall0.71413376
118MP0003868_abnormal_feces_composition0.70740024
119MP0003959_abnormal_lean_body0.69998629
120MP0000747_muscle_weakness0.69752625
121MP0005501_abnormal_skin_physiology0.69484639
122MP0000627_abnormal_mammary_gland0.69199172
123MP0001849_ear_inflammation0.68240371
124MP0004510_myositis0.68158612
125MP0002269_muscular_atrophy0.67957561
126MP0009250_abnormal_appendicular_skeleto0.67859300
127MP0005164_abnormal_response_to0.67532818
128MP0000163_abnormal_cartilage_morphology0.66957430
129MP0000579_abnormal_nail_morphology0.66609807
130MP0003984_embryonic_growth_retardation0.66605214
131MP0002088_abnormal_embryonic_growth/wei0.65376823
132MP0008260_abnormal_autophagy0.64928224
133MP0002086_abnormal_extraembryonic_tissu0.64382765
134MP0002136_abnormal_kidney_physiology0.64233557
135MP0005197_abnormal_uvea_morphology0.64207108
136MP0001175_abnormal_lung_morphology0.64143113
137MP0001853_heart_inflammation0.64068068
138MP0002254_reproductive_system_inflammat0.63757686
139MP0002452_abnormal_antigen_presenting0.63050412

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.73776219
2Protrusio acetabuli (HP:0003179)5.65336308
3Cerebral aneurysm (HP:0004944)4.54679132
4Increased connective tissue (HP:0009025)4.01101789
5Ankle contracture (HP:0006466)3.98578265
6Aortic dissection (HP:0002647)3.88647971
7Aortic aneurysm (HP:0004942)3.86282952
8Atrophic scars (HP:0001075)3.61248483
9Shallow orbits (HP:0000586)3.59257158
10Peritonitis (HP:0002586)3.49922851
11Cervical subluxation (HP:0003308)3.35135834
12Dilatation of the ascending aorta (HP:0005111)3.26376080
13Right ventricular cardiomyopathy (HP:0011663)3.26218120
14Broad metatarsal (HP:0001783)2.97745529
15Mitral valve prolapse (HP:0001634)2.92627966
16Muscle fiber splitting (HP:0003555)2.91903775
17Ulnar bowing (HP:0003031)2.89565959
18Osteolytic defects of the hand bones (HP:0009699)2.85306934
19Osteolytic defects of the phalanges of the hand (HP:0009771)2.85306934
20Aneurysm (HP:0002617)2.84500585
21Type 1 muscle fiber predominance (HP:0003803)2.81069626
22Fragile skin (HP:0001030)2.80901037
23Difficulty climbing stairs (HP:0003551)2.77509907
24Soft skin (HP:0000977)2.75882061
25Spinal rigidity (HP:0003306)2.74444252
26Broad face (HP:0000283)2.70263306
27Hyperacusis (HP:0010780)2.68592777
28Hematochezia (HP:0002573)2.65651555
29Bladder diverticulum (HP:0000015)2.61748230
30Wrist flexion contracture (HP:0001239)2.60666707
31Genu recurvatum (HP:0002816)2.53667793
32Hyporeflexia of lower limbs (HP:0002600)2.51267210
33Blue sclerae (HP:0000592)2.48550209
34Wormian bones (HP:0002645)2.39837023
35Camptodactyly of toe (HP:0001836)2.38574925
36Increased density of long bones (HP:0006392)2.38426289
37Achilles tendon contracture (HP:0001771)2.37647097
38Upper limb amyotrophy (HP:0009129)2.37381955
39Distal upper limb amyotrophy (HP:0007149)2.37381955
40Vertebral compression fractures (HP:0002953)2.32302241
41Natal tooth (HP:0000695)2.31523252
42Bowed forearm bones (HP:0003956)2.28433814
43Bowing of the arm (HP:0006488)2.28433814
44Mildly elevated creatine phosphokinase (HP:0008180)2.27178138
45Myocardial infarction (HP:0001658)2.26097177
46Short nail (HP:0001799)2.24434948
47Thin bony cortex (HP:0002753)2.19433910
48Abnormality of the Achilles tendon (HP:0005109)2.16020934
49Radial bowing (HP:0002986)2.15452932
50Disproportionate tall stature (HP:0001519)2.15203640
51Scapular winging (HP:0003691)2.14951947
52Increased variability in muscle fiber diameter (HP:0003557)2.14561840
53Ventricular tachycardia (HP:0004756)2.13805386
54Difficulty running (HP:0009046)2.08699117
55Generalized amyotrophy (HP:0003700)2.07469949
56Distal lower limb amyotrophy (HP:0008944)2.07252787
57Tibial bowing (HP:0002982)2.06822162
58Abnormality of the distal phalanges of the toes (HP:0010182)2.06594962
59Cellulitis (HP:0100658)2.06305501
60Interstitial pulmonary disease (HP:0006530)2.06070180
61Abnormality of skeletal muscle fiber size (HP:0012084)2.05658194
62Vascular tortuosity (HP:0004948)2.03152327
63Abnormality of the calcaneus (HP:0008364)2.01896818
64Polycythemia (HP:0001901)2.01380231
65Advanced eruption of teeth (HP:0006288)1.99953827
66Long toe (HP:0010511)1.97821488
67Reduced subcutaneous adipose tissue (HP:0003758)1.97223483
68Elbow flexion contracture (HP:0002987)1.95617452
69Hand muscle atrophy (HP:0009130)1.95064234
70Flexion contracture of toe (HP:0005830)1.94376557
71Joint contractures involving the joints of the feet (HP:0100492)1.94376557
72Abnormality of the acetabulum (HP:0003170)1.94299935
73Increased mean platelet volume (HP:0011877)1.94283727
74Joint stiffness (HP:0001387)1.94054836
75Bowel diverticulosis (HP:0005222)1.94021279
76Lipoatrophy (HP:0100578)1.93827197
77Abnormality of carpal bone ossification (HP:0006257)1.91858631
78Cardiovascular calcification (HP:0011915)1.91825091
79Lower limb amyotrophy (HP:0007210)1.91468201
80Ectopia lentis (HP:0001083)1.91024582
81Chondrocalcinosis (HP:0000934)1.90909568
82Biconcave vertebral bodies (HP:0004586)1.90654371
83Abnormal ossification of hand bones (HP:0005921)1.90248134
84Coxa vara (HP:0002812)1.89955402
85Mesangial abnormality (HP:0001966)1.89163750
86Overgrowth (HP:0001548)1.89154802
87Abnormality of dentin (HP:0010299)1.88439678
88Abnormality of the peritoneum (HP:0002585)1.88122439
89Back pain (HP:0003418)1.87133032
90Mitral regurgitation (HP:0001653)1.85656837
91Lymphangioma (HP:0100764)1.84554851
92Round ear (HP:0100830)1.84361475
93Acanthosis nigricans (HP:0000956)1.83980365
94Spinal cord compression (HP:0002176)1.82915878
95Trismus (HP:0000211)1.82774517
96Stridor (HP:0010307)1.81263411
97Aortic valve stenosis (HP:0001650)1.80846653
98Slender build (HP:0001533)1.80245861
99Nonimmune hydrops fetalis (HP:0001790)1.80045205
100Follicular hyperkeratosis (HP:0007502)1.79757433
101Abnormal platelet volume (HP:0011876)1.79455955
102Facial diplegia (HP:0001349)1.78576297
103Persistence of primary teeth (HP:0006335)1.77878299
104Emphysema (HP:0002097)1.77346333
105Neonatal short-limb short stature (HP:0008921)1.76797468
106Venous abnormality (HP:0002624)1.76450504
107Flat acetabular roof (HP:0003180)1.75750642
108Distal lower limb muscle weakness (HP:0009053)1.75194599
109Asymmetric septal hypertrophy (HP:0001670)1.75194193
110Arterial tortuosity (HP:0005116)1.75185255
111Mitral stenosis (HP:0001718)1.74892221
112Aortic regurgitation (HP:0001659)1.74809543
113Hemorrhage of the eye (HP:0011885)1.73083387
114Abnormal delivery (HP:0001787)1.71802935
115Abnormality of Sharpey fibers (HP:0100685)1.69364684
116Hyperextensible skin (HP:0000974)1.68649670
117Congenital glaucoma (HP:0001087)1.67240067
118Wide anterior fontanel (HP:0000260)1.66940958
119Joint laxity (HP:0001388)1.66915274
120Asymmetry of the thorax (HP:0001555)1.66307323
121Striae distensae (HP:0001065)1.64748246
122Spondylolisthesis (HP:0003302)1.62596450
123Esophageal varix (HP:0002040)1.62579667
124Hypertriglyceridemia (HP:0002155)1.61867749
125Breech presentation (HP:0001623)1.61550892
126Mucosal telangiectasiae (HP:0100579)1.61146159
127Rectal prolapse (HP:0002035)1.60958242
128Verrucae (HP:0200043)1.60005932
129Axonal loss (HP:0003447)1.59205598

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.82046585
2TTN4.15975570
3ERN13.36033054
4PKN23.15935267
5MAP3K102.40922720
6SMG12.36118319
7EEF2K2.29469329
8EPHA22.17444489
9IRAK32.17334872
10ICK2.14415850
11RIPK12.14305695
12TGFBR22.00052667
13PDGFRA1.99711269
14LRRK21.98098096
15LATS11.96384102
16SIK11.88651474
17PTK61.77028408
18CAMK1D1.66627234
19STK101.63829630
20TIE11.60803808
21DDR21.58485755
22NTRK11.49456820
23MAP2K31.44651870
24MAP3K31.41741520
25TRPM71.40208108
26KDR1.38532473
27LIMK11.35193388
28PAK41.31060893
29RPS6KA41.28952501
30CDK121.26864405
31BMX1.25748900
32MAPKAPK31.24220119
33PAK21.24179833
34PRPF4B1.22613540
35EPHB11.21183523
36DMPK1.19237837
37STK31.14631395
38NEK91.12341475
39PTK21.08341149
40MAP3K61.04817454
41EPHB21.04637318
42TBK11.04006094
43FGFR41.03980135
44MYLK1.03958781
45MTOR1.01962607
46JAK11.01052590
47LATS21.00625457
48MAP4K11.00021924
49RPS6KA20.99518185
50TESK10.98917393
51JAK30.96607831
52ARAF0.96496819
53TYK20.94390962
54CAMK1G0.92526849
55RPS6KB20.91981901
56STK380.90000604
57FER0.88912695
58ERBB40.87786525
59TGFBR10.87534296
60ILK0.86855439
61FLT30.85637874
62CDK60.83596039
63ABL20.83000912
64PDGFRB0.78328826
65SCYL20.77514717
66TAOK20.77245400
67MAP3K80.76372491
68PRKD30.74754853
69MAP2K10.74508117
70FGFR30.73829090
71CSF1R0.73805767
72FRK0.72908433
73PTK2B0.72312571
74KIT0.71733891
75PRKD10.71351122
76MET0.70385892
77CSK0.69965326
78MST1R0.68175962
79PDPK10.66835803
80PIK3CA0.62733200
81PIM20.62660132
82NEK20.62646764
83PAK30.62355736
84PIK3CG0.61677667
85ZAP700.59468460
86DAPK30.58431245
87PDK40.57952709
88PDK30.57952709
89CDK40.55561191
90EPHA30.55182953
91PRKG20.54875667
92LMTK20.54761301
93MOS0.53105858
94ROCK20.50721488
95MELK0.50408004
96ROCK10.50400370
97PIM10.49165581
98HCK0.48458342
99TESK20.48401245
100PDK20.47594173
101GSK3A0.47190866
102CHUK0.47141531
103AKT30.47098104
104MARK20.45707199
105RPS6KC10.44827573
106RPS6KL10.44827573
107CDK70.44231574
108PRKD20.44085062
109STK40.43161209
110STK38L0.43130696
111RET0.42808831
112IKBKB0.42719781
113MAPKAPK20.42295935
114INSR0.42088431
115CDK80.40770978
116MAP3K130.40698357
117NME20.40279446
118FGFR10.39936408
119ABL10.39176525
120GRK60.38940068
121CAMK2G0.38466268
122DYRK1B0.38361396
123PRKAA20.38268441
124CDK90.37902925
125BRAF0.37630958
126CDC42BPA0.37356119
127AKT20.36918756
128EGFR0.36918382
129KSR20.36468132
130PAK10.36255628
131MAPK110.36052038
132TAOK10.35869287
133BLK0.35781929
134MAP3K10.35465368
135PRKCI0.34315203
136MAP2K20.29993856
137RPS6KA60.26263455

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.97842671
2Focal adhesion_Homo sapiens_hsa045102.58234730
3Small cell lung cancer_Homo sapiens_hsa052222.28416962
4Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.10295285
5Proteoglycans in cancer_Homo sapiens_hsa052051.96777325
6Adherens junction_Homo sapiens_hsa045201.96088749
7AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.95369461
8Amoebiasis_Homo sapiens_hsa051461.87921620
9Leukocyte transendothelial migration_Homo sapiens_hsa046701.82777348
10Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.80418031
11Viral myocarditis_Homo sapiens_hsa054161.71140890
12Chronic myeloid leukemia_Homo sapiens_hsa052201.70387802
13Dilated cardiomyopathy_Homo sapiens_hsa054141.64993266
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.60977818
15Toxoplasmosis_Homo sapiens_hsa051451.59759471
16Cyanoamino acid metabolism_Homo sapiens_hsa004601.58544537
17Bladder cancer_Homo sapiens_hsa052191.57530130
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.55493607
19Malaria_Homo sapiens_hsa051441.49464338
20B cell receptor signaling pathway_Homo sapiens_hsa046621.48628121
21MicroRNAs in cancer_Homo sapiens_hsa052061.44787091
22Galactose metabolism_Homo sapiens_hsa000521.40806338
23Phenylalanine metabolism_Homo sapiens_hsa003601.40519916
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.39202285
25Shigellosis_Homo sapiens_hsa051311.37003750
26Fructose and mannose metabolism_Homo sapiens_hsa000511.36781452
27Pentose phosphate pathway_Homo sapiens_hsa000301.34661238
28PPAR signaling pathway_Homo sapiens_hsa033201.32890581
29Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.32842960
30Leishmaniasis_Homo sapiens_hsa051401.32804608
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.31531500
32Adipocytokine signaling pathway_Homo sapiens_hsa049201.28681831
33Thyroid cancer_Homo sapiens_hsa052161.27451959
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.27447069
35Pancreatic cancer_Homo sapiens_hsa052121.26321094
36Insulin resistance_Homo sapiens_hsa049311.25562358
37Regulation of actin cytoskeleton_Homo sapiens_hsa048101.24075558
38Osteoclast differentiation_Homo sapiens_hsa043801.23132391
39Platelet activation_Homo sapiens_hsa046111.22802933
40Apoptosis_Homo sapiens_hsa042101.21915652
41Protein digestion and absorption_Homo sapiens_hsa049741.20552714
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.15529842
43Prion diseases_Homo sapiens_hsa050201.13932590
44Caffeine metabolism_Homo sapiens_hsa002321.13789617
45p53 signaling pathway_Homo sapiens_hsa041151.10360339
46NF-kappa B signaling pathway_Homo sapiens_hsa040641.08585682
47TNF signaling pathway_Homo sapiens_hsa046681.07825646
48PI3K-Akt signaling pathway_Homo sapiens_hsa041511.07108374
49HIF-1 signaling pathway_Homo sapiens_hsa040661.04850228
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.03904464
51Acute myeloid leukemia_Homo sapiens_hsa052211.03545420
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02450382
53TGF-beta signaling pathway_Homo sapiens_hsa043501.01496662
54Viral carcinogenesis_Homo sapiens_hsa052030.99586190
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98220658
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.96846778
57Biosynthesis of amino acids_Homo sapiens_hsa012300.95180869
58Salmonella infection_Homo sapiens_hsa051320.93858396
59Fatty acid degradation_Homo sapiens_hsa000710.93470662
60Hippo signaling pathway_Homo sapiens_hsa043900.93433054
61HTLV-I infection_Homo sapiens_hsa051660.93021510
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.91752711
63AMPK signaling pathway_Homo sapiens_hsa041520.91006198
64Sulfur relay system_Homo sapiens_hsa041220.90219665
65Tight junction_Homo sapiens_hsa045300.89667824
66mTOR signaling pathway_Homo sapiens_hsa041500.87785043
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87768632
68Vibrio cholerae infection_Homo sapiens_hsa051100.86799508
69Antigen processing and presentation_Homo sapiens_hsa046120.86277570
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.85752433
71VEGF signaling pathway_Homo sapiens_hsa043700.85529411
72Hematopoietic cell lineage_Homo sapiens_hsa046400.85254833
73Fatty acid biosynthesis_Homo sapiens_hsa000610.84659896
74Toll-like receptor signaling pathway_Homo sapiens_hsa046200.84387079
75Arginine biosynthesis_Homo sapiens_hsa002200.83425947
76Hepatitis B_Homo sapiens_hsa051610.82817356
77Lysine degradation_Homo sapiens_hsa003100.82363608
78Tuberculosis_Homo sapiens_hsa051520.80512859
79Pathways in cancer_Homo sapiens_hsa052000.80328775
80Lysosome_Homo sapiens_hsa041420.79900535
81Pertussis_Homo sapiens_hsa051330.79772875
82Sulfur metabolism_Homo sapiens_hsa009200.79676568
83Tyrosine metabolism_Homo sapiens_hsa003500.79273724
84Prostate cancer_Homo sapiens_hsa052150.78773400
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76354634
86Legionellosis_Homo sapiens_hsa051340.74722823
87Pyruvate metabolism_Homo sapiens_hsa006200.74055753
88Insulin signaling pathway_Homo sapiens_hsa049100.72872592
89Renin-angiotensin system_Homo sapiens_hsa046140.72492194
90N-Glycan biosynthesis_Homo sapiens_hsa005100.72413632
91Measles_Homo sapiens_hsa051620.72383767
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.72118999
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.71566672
94Melanoma_Homo sapiens_hsa052180.71541283
95Renal cell carcinoma_Homo sapiens_hsa052110.71215093
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.70369151
97Fatty acid metabolism_Homo sapiens_hsa012120.68381311
98Notch signaling pathway_Homo sapiens_hsa043300.68338003
99Rap1 signaling pathway_Homo sapiens_hsa040150.67758731
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67186267
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.67111191
102FoxO signaling pathway_Homo sapiens_hsa040680.66078762
103Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65977720
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65123090
105Vitamin B6 metabolism_Homo sapiens_hsa007500.65103580
106Non-small cell lung cancer_Homo sapiens_hsa052230.65024343
107Estrogen signaling pathway_Homo sapiens_hsa049150.64443064
108Glioma_Homo sapiens_hsa052140.64266249
109Melanogenesis_Homo sapiens_hsa049160.63446856
110Basal cell carcinoma_Homo sapiens_hsa052170.62954505
111Influenza A_Homo sapiens_hsa051640.62526474
112GnRH signaling pathway_Homo sapiens_hsa049120.62337063
113Glucagon signaling pathway_Homo sapiens_hsa049220.61519072
114Complement and coagulation cascades_Homo sapiens_hsa046100.61208595
115Endocytosis_Homo sapiens_hsa041440.61024494
116Carbon metabolism_Homo sapiens_hsa012000.60799727
117Axon guidance_Homo sapiens_hsa043600.59994504
118Staphylococcus aureus infection_Homo sapiens_hsa051500.59737899
119Gap junction_Homo sapiens_hsa045400.58188436
120Other glycan degradation_Homo sapiens_hsa005110.58056520
121Bile secretion_Homo sapiens_hsa049760.57250617
122Endometrial cancer_Homo sapiens_hsa052130.56339214
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56060645
124Hepatitis C_Homo sapiens_hsa051600.55713640
125Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55604815
126ErbB signaling pathway_Homo sapiens_hsa040120.55406734
127Sphingolipid metabolism_Homo sapiens_hsa006000.54858427
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54397779
129Vascular smooth muscle contraction_Homo sapiens_hsa042700.54228755
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54014104
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52213693
132Propanoate metabolism_Homo sapiens_hsa006400.52092987
133Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51391574
134Glycerolipid metabolism_Homo sapiens_hsa005610.51033935
135Phagosome_Homo sapiens_hsa041450.49505066
136Primary immunodeficiency_Homo sapiens_hsa053400.48724526

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