MYO1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional skeletal muscle myosin-1 (MYH1). Unconventional myosins contain the basic domains characteristic of conventional myosins and are further distinguished from class members by their tail domains. They function as actin-based molecular motors. Mutations in this gene have been associated with autosomal dominant deafness. Alternatively spliced variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1angiotensin maturation (GO:0002003)9.52822419
2regulation of guanylate cyclase activity (GO:0031282)7.67066431
3vitamin A metabolic process (GO:0006776)6.62585111
4epoxygenase P450 pathway (GO:0019373)6.37523247
5fat-soluble vitamin biosynthetic process (GO:0042362)6.33992495
6regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)6.23341630
7actin filament depolymerization (GO:0030042)6.12002891
8UDP-N-acetylglucosamine metabolic process (GO:0006047)6.03126490
93-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)5.85286532
10purine ribonucleoside bisphosphate metabolic process (GO:0034035)5.85286532
11bundle of His cell to Purkinje myocyte communication (GO:0086069)5.77772873
12positive regulation of guanylate cyclase activity (GO:0031284)5.76676437
13maintenance of gastrointestinal epithelium (GO:0030277)5.72260163
14digestive system process (GO:0022600)5.64496998
15sulfate transmembrane transport (GO:1902358)5.61800779
16flavonoid metabolic process (GO:0009812)5.61139269
17fructose metabolic process (GO:0006000)5.51707057
18regulation of bile acid biosynthetic process (GO:0070857)5.43611578
19adhesion of symbiont to host cell (GO:0044650)5.37262507
20virion attachment to host cell (GO:0019062)5.37262507
21regulation of cellular extravasation (GO:0002691)5.32255574
22bile acid and bile salt transport (GO:0015721)5.24883550
23intestinal epithelial cell development (GO:0060576)5.10934418
24drug catabolic process (GO:0042737)4.92129319
25drug metabolic process (GO:0017144)4.70032762
26regulation of cGMP biosynthetic process (GO:0030826)4.65405457
27sulfate transport (GO:0008272)4.61350485
28cellular response to hepatocyte growth factor stimulus (GO:0035729)4.55687785
29response to hepatocyte growth factor (GO:0035728)4.55687785
30digestion (GO:0007586)4.51415926
31glucose 6-phosphate metabolic process (GO:0051156)4.49975388
32urea cycle (GO:0000050)4.44838445
33renal system process involved in regulation of blood volume (GO:0001977)4.37630457
34epithelial structure maintenance (GO:0010669)4.35682453
35O-glycan processing (GO:0016266)4.33946339
36phospholipid efflux (GO:0033700)4.32411450
37cellular glucuronidation (GO:0052695)4.30867949
38sulfation (GO:0051923)4.28379285
39adhesion of symbiont to host (GO:0044406)4.27438513
40glucuronate metabolic process (GO:0019585)4.25810653
41uronic acid metabolic process (GO:0006063)4.25810653
42modified amino acid transport (GO:0072337)4.24630561
43urea metabolic process (GO:0019627)4.23885782
44sulfur compound transport (GO:0072348)4.19288245
45plasma lipoprotein particle assembly (GO:0034377)4.16805164
46triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.16729039
47positive regulation of pseudopodium assembly (GO:0031274)4.09712954
48regulation of cholesterol esterification (GO:0010872)4.06208164
49glycolipid catabolic process (GO:0019377)4.02871943
50protein-lipid complex assembly (GO:0065005)4.02855640
51bicarbonate transport (GO:0015701)4.02384193
52hormone catabolic process (GO:0042447)4.01030752
53glycosphingolipid catabolic process (GO:0046479)4.00463548
54positive regulation of triglyceride lipase activity (GO:0061365)4.00450038
55positive regulation of lipoprotein lipase activity (GO:0051006)4.00450038
56sperm capacitation (GO:0048240)3.99246847
57lipoprotein metabolic process (GO:0042157)3.97634553
58nitrogen cycle metabolic process (GO:0071941)3.90970870
59regulation of triglyceride catabolic process (GO:0010896)3.86378613
60regulation of cGMP metabolic process (GO:0030823)3.85297168
61vitamin transmembrane transport (GO:0035461)3.77238781
62regulation of cholesterol homeostasis (GO:2000188)3.70446736
63cellular response to nitric oxide (GO:0071732)3.69556903
64peptide hormone processing (GO:0016486)3.68575120
65regulation of pseudopodium assembly (GO:0031272)3.66706442
66positive regulation of glycoprotein biosynthetic process (GO:0010560)3.66493600
67very-low-density lipoprotein particle assembly (GO:0034379)3.66074584
68transcytosis (GO:0045056)3.62531666
69lipoprotein transport (GO:0042953)3.62275529
70cholesterol homeostasis (GO:0042632)3.61890365
71diacylglycerol metabolic process (GO:0046339)3.60195771
72sterol homeostasis (GO:0055092)3.59043423
73negative regulation of sterol transport (GO:0032372)3.56588284
74negative regulation of cholesterol transport (GO:0032375)3.56588284
75antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.55482823
76positive regulation of respiratory burst (GO:0060267)3.55073826
77regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.55067987
78homocysteine metabolic process (GO:0050667)3.53625749
79peptide catabolic process (GO:0043171)3.51168059
80cholesterol efflux (GO:0033344)3.49233040
81striated muscle atrophy (GO:0014891)3.47698602
82vitamin transport (GO:0051180)3.47093552
83antibacterial humoral response (GO:0019731)3.45771916
84transepithelial transport (GO:0070633)3.44678757
85cGMP-mediated signaling (GO:0019934)3.43953889
86response to nitric oxide (GO:0071731)3.43125582
87phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.42386604
88antimicrobial humoral response (GO:0019730)3.42321770
89drinking behavior (GO:0042756)3.41883990
90thyroid hormone metabolic process (GO:0042403)3.41735532
91antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.41337004
92glutamine family amino acid biosynthetic process (GO:0009084)3.36441752
93fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.33182479
94positive regulation of glycoprotein metabolic process (GO:1903020)3.33110717
95arginine metabolic process (GO:0006525)3.32736778
96hepatocyte apoptotic process (GO:0097284)3.32431700
97positive regulation of cGMP biosynthetic process (GO:0030828)3.32297073
98fat-soluble vitamin metabolic process (GO:0006775)3.31070908
99negative regulation of keratinocyte proliferation (GO:0010839)3.30726016
100antigen processing and presentation of endogenous antigen (GO:0019883)3.29321449
101regulation of actin nucleation (GO:0051125)3.27984354
102sterol transport (GO:0015918)3.27668961
103cholesterol transport (GO:0030301)3.27668961
104cellular response to reactive nitrogen species (GO:1902170)3.26882357
105nucleoside diphosphate biosynthetic process (GO:0009133)3.25318404
106positive regulation of T cell differentiation in thymus (GO:0033089)3.24725435
107ceramide catabolic process (GO:0046514)3.21263624
108regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.20162668
109endocrine process (GO:0050886)3.20162668
110regulation of systemic arterial blood pressure by hormone (GO:0001990)3.20162668
111sexual reproduction (GO:0019953)3.19895750
112calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.18177447
113renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.15762476
114thrombin receptor signaling pathway (GO:0070493)3.15286229
115hemidesmosome assembly (GO:0031581)3.13420528
116cGMP biosynthetic process (GO:0006182)3.12459384
117glycosylceramide metabolic process (GO:0006677)3.11758468
118regulation of viral release from host cell (GO:1902186)3.10417723
119bile acid metabolic process (GO:0008206)3.09634658
120glycerol metabolic process (GO:0006071)3.07977212
121midgut development (GO:0007494)3.07667383
122positive regulation of lipid catabolic process (GO:0050996)3.07594267
123sphingolipid catabolic process (GO:0030149)3.06970294
124vitamin biosynthetic process (GO:0009110)3.06410870
125alkaloid metabolic process (GO:0009820)3.04432160
126desmosome organization (GO:0002934)3.04180991
127leukotriene metabolic process (GO:0006691)3.03583909
128glomerular filtration (GO:0003094)3.03063800
129oligosaccharide catabolic process (GO:0009313)3.01560085
130sphingomyelin metabolic process (GO:0006684)3.01349467
131skeletal muscle adaptation (GO:0043501)3.01307731
132positive regulation of fatty acid biosynthetic process (GO:0045723)3.00437288
133cytidine deamination (GO:0009972)2.98233334
134cytidine metabolic process (GO:0046087)2.98233334
135cytidine catabolic process (GO:0006216)2.98233334
136receptor guanylyl cyclase signaling pathway (GO:0007168)2.96111147
137regulation of vitamin metabolic process (GO:0030656)2.90997855
138nucleotide-sugar biosynthetic process (GO:0009226)2.90623339
139epithelial cell-cell adhesion (GO:0090136)2.89206390
140exogenous drug catabolic process (GO:0042738)2.87824181
141muscle atrophy (GO:0014889)2.87287081
142ventricular cardiac muscle cell action potential (GO:0086005)2.86992588
143regulation of systemic arterial blood pressure (GO:0003073)2.86971009
144protein-lipid complex remodeling (GO:0034368)2.86733433
145macromolecular complex remodeling (GO:0034367)2.86733433
146plasma lipoprotein particle remodeling (GO:0034369)2.86733433
147membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.85309865
148nucleotide-sugar metabolic process (GO:0009225)2.83694660
149NADH metabolic process (GO:0006734)2.81638580
150drug transport (GO:0015893)2.81041777
151protein-lipid complex subunit organization (GO:0071825)2.78780441
152intestinal absorption (GO:0050892)11.5429678
153intestinal cholesterol absorption (GO:0030299)10.1629898

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.32437810
2CDX2_20551321_ChIP-Seq_CACO-2_Human5.73195780
3SOX2_27498859_Chip-Seq_STOMACH_Mouse3.97021686
4GATA4_25053715_ChIP-Seq_YYC3_Human3.13118026
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.06763526
6GATA6_25053715_ChIP-Seq_YYC3_Human2.96254056
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.80317787
8SOX2_20726797_ChIP-Seq_SW620_Human2.79524604
9CDX2_19796622_ChIP-Seq_MESCs_Mouse2.75313466
10* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.68434745
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.45034502
12PPARA_22158963_ChIP-Seq_LIVER_Mouse2.44197512
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.43098760
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.24442412
15PPAR_26484153_Chip-Seq_NCI-H1993_Human2.17537166
16GATA1_22025678_ChIP-Seq_K562_Human2.13425834
17LXR_22158963_ChIP-Seq_LIVER_Mouse2.10962915
18SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.06945930
19SRY_22984422_ChIP-ChIP_TESTIS_Rat1.98132907
20RXR_22158963_ChIP-Seq_LIVER_Mouse1.97090406
21KLF5_25053715_ChIP-Seq_YYC3_Human1.92724502
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.81692448
23RUNX1_27514584_Chip-Seq_MCF-7_Human1.80994701
24TCF4_18268006_ChIP-ChIP_LS174T_Human1.80175764
25STAT6_21828071_ChIP-Seq_BEAS2B_Human1.78771333
26NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.73926413
27CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.71866926
28FOXO3_23340844_ChIP-Seq_DLD1_Human1.69263700
29VDR_22108803_ChIP-Seq_LS180_Human1.69000925
30RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68707474
31PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.68265575
32KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.67406541
33CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.64120763
34KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.62772426
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.61774096
36FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.61725686
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.59617156
38ESR1_20079471_ChIP-ChIP_T-47D_Human1.59143650
39RACK7_27058665_Chip-Seq_MCF-7_Human1.56762216
40ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.54576180
41FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.49216085
42NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.48305051
43IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.45609319
44ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.42754936
45ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.40781342
46IRF8_21731497_ChIP-ChIP_J774_Mouse1.40503755
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.38193782
48ATF3_27146783_Chip-Seq_COLON_Human1.38005343
49BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.36659863
50SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.32873905
51MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.32593554
52* GATA2_19941826_ChIP-Seq_K562_Human1.26617528
53HNF4A_19822575_ChIP-Seq_HepG2_Human1.26189423
54FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.25830599
55ESR1_21235772_ChIP-Seq_MCF-7_Human1.20854616
56ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18574451
57VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18066750
58SA1_27219007_Chip-Seq_Bcells_Human1.16578853
59NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.16029217
60KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16004490
61PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.15446626
62GATA1_26923725_Chip-Seq_HPCs_Mouse1.15212160
63ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.13759354
64STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.13038396
65AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.13028418
66FOXA2_19822575_ChIP-Seq_HepG2_Human1.12147304
67* TET1_21451524_ChIP-Seq_MESCs_Mouse1.10649119
68JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.10406817
69ZNF263_19887448_ChIP-Seq_K562_Human1.10277047
70RARG_19884340_ChIP-ChIP_MEFs_Mouse1.09471625
71SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09163863
72PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.08130205
73CTNNB1_20460455_ChIP-Seq_HCT116_Human1.07197025
74EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06900116
75HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05613578
76JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05483335
77CREB1_26743006_Chip-Seq_LNCaP_Human1.05307900
78AR_21909140_ChIP-Seq_LNCAP_Human1.04586963
79THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02473637
80SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01215742
81* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01113352
82SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.99409337
83SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.99409337
84CLOCK_20551151_ChIP-Seq_293T_Human0.99292294
85EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98911611
86GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98697924
87GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98018799
88VDR_24763502_ChIP-Seq_THP-1_Human0.97880515
89TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97134352
90DROSHA_22980978_ChIP-Seq_HELA_Human0.96625672
91EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96575658
92SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94994259
93NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.94717024
94FOXA1_25552417_ChIP-Seq_VCAP_Human0.94669808
95DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94573777
96SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93645490
97FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.93066355
98EGR1_19032775_ChIP-ChIP_M12_Human0.92939227
99RXR_22108803_ChIP-Seq_LS180_Human0.92864609
100TCF3_18692474_ChIP-Seq_MEFs_Mouse0.91857994
101GATA3_24758297_ChIP-Seq_MCF-7_Human0.90637297
102CEBPB_22108803_ChIP-Seq_LS180_Human0.87453983
103GATA1_22383799_ChIP-Seq_G1ME_Mouse0.87234758
104PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87047821
105VDR_24787735_ChIP-Seq_THP-1_Human0.87025582
106CDX2_22108803_ChIP-Seq_LS180_Human0.86901048
107STAT1_20625510_ChIP-Seq_HELA_Human0.85354759
108SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.84989937
109RAD21_21589869_ChIP-Seq_MESCs_Mouse0.84910027
110GATA1_19941826_ChIP-Seq_K562_Human0.84695641
111LXR_22292898_ChIP-Seq_THP-1_Human0.84230104
112POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.84198671
113GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.83945121
114FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82834774
115CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.82684343
116* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82515832
117P63_26484246_Chip-Seq_KERATINOCYTES_Human0.82142283
118BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.82105262
119FOXM1_26456572_ChIP-Seq_MCF-7_Human0.81630428
120TP63_22573176_ChIP-Seq_HFKS_Human0.81578129
121NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.80389083
122SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.79805606
123CTCF_27219007_Chip-Seq_Bcells_Human0.79139201
124NANOG_20526341_ChIP-Seq_ESCs_Human0.78979725
125P300_27058665_Chip-Seq_ZR-75-30cells_Human0.78106451
126GATA2_21666600_ChIP-Seq_HMVEC_Human0.77874753
127BCAT_22108803_ChIP-Seq_LS180_Human0.77773089
128JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77632288
129BCOR_27268052_Chip-Seq_Bcells_Human0.77539428
130UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.77102650
131BCL6_27268052_Chip-Seq_Bcells_Human0.75388180

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.77875938
2MP0001666_abnormal_nutrient_absorption5.72389773
3MP0010234_abnormal_vibrissa_follicle5.37055497
4MP0004264_abnormal_extraembryonic_tissu4.05230149
5MP0000462_abnormal_digestive_system3.70776181
6MP0003866_abnormal_defecation3.59153995
7MP0005085_abnormal_gallbladder_physiolo3.18416377
8MP0003183_abnormal_peptide_metabolism3.07975435
9MP0009840_abnormal_foam_cell2.97692012
10MP0002822_catalepsy2.79976958
11MP0003252_abnormal_bile_duct2.77990584
12MP0002139_abnormal_hepatobiliary_system2.74963309
13MP0008875_abnormal_xenobiotic_pharmacok2.68956176
14MP0003283_abnormal_digestive_organ2.43466018
15MP0001873_stomach_inflammation2.40560551
16MP0005377_hearing/vestibular/ear_phenot2.37379551
17MP0003878_abnormal_ear_physiology2.37379551
18MP0001663_abnormal_digestive_system2.34262740
19MP0010155_abnormal_intestine_physiology2.33489121
20MP0005381_digestive/alimentary_phenotyp2.32303387
21MP0005409_darkened_coat_color2.24169024
22MP0000537_abnormal_urethra_morphology2.23141134
23MP0001664_abnormal_digestion2.22745312
24MP0010329_abnormal_lipoprotein_level2.10165431
25MP0010352_gastrointestinal_tract_polyps2.09779862
26MP0003300_gastrointestinal_ulcer2.04288478
27MP0005365_abnormal_bile_salt2.02515823
28MP0000490_abnormal_crypts_of1.94608381
29MP0003705_abnormal_hypodermis_morpholog1.88645085
30* MP0000477_abnormal_intestine_morphology1.88332799
31MP0004019_abnormal_vitamin_homeostasis1.80748085
32MP0004147_increased_porphyrin_level1.80724860
33MP0000538_abnormal_urinary_bladder1.72855992
34MP0004043_abnormal_pH_regulation1.60393883
35MP0005670_abnormal_white_adipose1.47990601
36MP0005084_abnormal_gallbladder_morpholo1.45669991
37MP0002796_impaired_skin_barrier1.40321293
38MP0001188_hyperpigmentation1.39268597
39MP0004858_abnormal_nervous_system1.38902571
40MP0006054_spinal_hemorrhage1.38754423
41MP0005167_abnormal_blood-brain_barrier1.36962272
42MP0005448_abnormal_energy_balance1.25343914
43MP0003868_abnormal_feces_composition1.23687972
44MP0004782_abnormal_surfactant_physiolog1.22819842
45MP0001849_ear_inflammation1.21645934
46MP0010678_abnormal_skin_adnexa1.20449209
47MP0009053_abnormal_anal_canal1.17214588
48MP0003191_abnormal_cellular_cholesterol1.16119534
49MP0009643_abnormal_urine_homeostasis1.12497048
50MP0003315_abnormal_perineum_morphology1.09398209
51MP0001765_abnormal_ion_homeostasis1.09182257
52MP0009379_abnormal_foot_pigmentation1.07837063
53MP0004947_skin_inflammation1.06879424
54MP0002089_abnormal_postnatal_growth/wei1.05870745
55MP0009780_abnormal_chondrocyte_physiolo1.03203233
56MP0002254_reproductive_system_inflammat1.02984468
57MP0003806_abnormal_nucleotide_metabolis1.02497545
58MP0001501_abnormal_sleep_pattern1.02452681
59MP0008004_abnormal_stomach_pH1.02422565
60MP0000467_abnormal_esophagus_morphology0.97779195
61MP0002971_abnormal_brown_adipose0.94236757
62MP0005535_abnormal_body_temperature0.91252884
63MP0000516_abnormal_urinary_system0.91135158
64MP0005367_renal/urinary_system_phenotyp0.91135158
65MP0002098_abnormal_vibrissa_morphology0.88131790
66MP0000470_abnormal_stomach_morphology0.86703060
67MP0009785_altered_susceptibility_to0.86582727
68MP0002118_abnormal_lipid_homeostasis0.86375140
69MP0005501_abnormal_skin_physiology0.86120986
70MP0004270_analgesia0.85964036
71MP0000465_gastrointestinal_hemorrhage0.85918331
72MP0008872_abnormal_physiological_respon0.85709803
73MP0000230_abnormal_systemic_arterial0.85360684
74MP0003453_abnormal_keratinocyte_physiol0.84677587
75MP0003724_increased_susceptibility_to0.84207914
76MP0002138_abnormal_hepatobiliary_system0.83468851
77MP0005636_abnormal_mineral_homeostasis0.83222774
78MP0002277_abnormal_respiratory_mucosa0.82222796
79MP0005310_abnormal_salivary_gland0.81476880
80MP0002166_altered_tumor_susceptibility0.81003916
81MP0009384_cardiac_valve_regurgitation0.80145988
82MP0005166_decreased_susceptibility_to0.79995362
83MP0000609_abnormal_liver_physiology0.79460591
84MP0001835_abnormal_antigen_presentation0.78095975
85MP0008469_abnormal_protein_level0.74336216
86MP0002876_abnormal_thyroid_physiology0.74039553
87MP0005332_abnormal_amino_acid0.73277588
88MP0005025_abnormal_response_to0.72618730
89MP0003303_peritoneal_inflammation0.72437433
90MP0005451_abnormal_body_composition0.71746959
91MP0003436_decreased_susceptibility_to0.71554330
92MP0002396_abnormal_hematopoietic_system0.68043209
93MP0001216_abnormal_epidermal_layer0.67865416
94MP0003879_abnormal_hair_cell0.67442696
95MP0001485_abnormal_pinna_reflex0.67041628
96MP0000604_amyloidosis0.65162170
97MP0001790_abnormal_immune_system0.64174088
98MP0005387_immune_system_phenotype0.64174088
99MP0003329_amyloid_beta_deposits0.63859791
100MP0006082_CNS_inflammation0.62800715
101MP0005266_abnormal_metabolism0.62140894
102MP0000613_abnormal_salivary_gland0.61795655
103MP0000249_abnormal_blood_vessel0.61376910
104MP0002896_abnormal_bone_mineralization0.60647774
105MP0002136_abnormal_kidney_physiology0.59270424
106MP0009333_abnormal_splenocyte_physiolog0.58324530
107MP0009764_decreased_sensitivity_to0.56127957
108MP0005058_abnormal_lysosome_morphology0.55991932
109MP0003045_fibrosis0.53993146
110MP0005319_abnormal_enzyme/_coenzyme0.53658321
111MP0000678_abnormal_parathyroid_gland0.52943106
112MP0001881_abnormal_mammary_gland0.50791921
113MP0003718_maternal_effect0.50414236
114MP0002006_tumorigenesis0.50084279
115MP0005334_abnormal_fat_pad0.49470281
116MP0005174_abnormal_tail_pigmentation0.48686561
117MP0002148_abnormal_hypersensitivity_rea0.48004153
118MP0000566_synostosis0.46610108
119MP0002078_abnormal_glucose_homeostasis0.46447034
120MP0001756_abnormal_urination0.46293486
121MP0009697_abnormal_copulation0.46067780
122MP0000377_abnormal_hair_follicle0.45380025
123MP0009642_abnormal_blood_homeostasis0.42723594
124MP0008873_increased_physiological_sensi0.40894064
125MP0001191_abnormal_skin_condition0.39890657
126MP0001764_abnormal_homeostasis0.39600612
127MP0001845_abnormal_inflammatory_respons0.39590845
128MP0005584_abnormal_enzyme/coenzyme_acti0.39194218
129MP0003693_abnormal_embryo_hatching0.39146123
130MP0003566_abnormal_cell_adhesion0.38543475
131MP0002060_abnormal_skin_morphology0.36802433
132MP0005376_homeostasis/metabolism_phenot0.36188077
133MP0004484_altered_response_of0.35112103
134MP0010771_integument_phenotype0.34287726
135MP0009115_abnormal_fat_cell0.34254515
136MP0005023_abnormal_wound_healing0.34073215
137MP0003950_abnormal_plasma_membrane0.33804999
138MP0005666_abnormal_adipose_tissue0.33746615

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)9.08460137
2Right ventricular cardiomyopathy (HP:0011663)5.96591141
3Abnormality of glutamine family amino acid metabolism (HP:0010902)5.72740731
4Acanthocytosis (HP:0001927)5.54086952
5Malnutrition (HP:0004395)5.24283106
6Hypobetalipoproteinemia (HP:0003563)5.09869449
7Conjugated hyperbilirubinemia (HP:0002908)4.80669072
8Abdominal distention (HP:0003270)4.52261424
9Cupped ribs (HP:0000887)4.48555306
10Flat acetabular roof (HP:0003180)4.42104770
11Chronic diarrhea (HP:0002028)4.40392640
12Confusion (HP:0001289)4.35574285
13Systemic lupus erythematosus (HP:0002725)4.34125105
14Hydroxyprolinuria (HP:0003080)4.29541080
15Abnormality of proline metabolism (HP:0010907)4.29541080
16Autoimmune thrombocytopenia (HP:0001973)3.92509847
17Abnormality of the 1st metacarpal (HP:0010009)3.79858668
18Decreased circulating renin level (HP:0003351)3.71073513
19Fat malabsorption (HP:0002630)3.70211868
20Nausea (HP:0002018)3.56241413
21Gastrointestinal dysmotility (HP:0002579)3.40034120
22Abnormality of the distal phalanx of the thumb (HP:0009617)3.38594398
23Widely patent fontanelles and sutures (HP:0004492)3.28034628
24Autoimmune hemolytic anemia (HP:0001890)3.25671868
25Hyperactive renin-angiotensin system (HP:0000841)3.25491126
26Alkalosis (HP:0001948)3.23774668
27Proximal tubulopathy (HP:0000114)3.22954212
28Abnormality of serine family amino acid metabolism (HP:0010894)3.16192291
29Abnormality of glycine metabolism (HP:0010895)3.16192291
30Poikilocytosis (HP:0004447)3.15743401
31Pigmentary retinal degeneration (HP:0001146)3.15148649
32Mildly elevated creatine phosphokinase (HP:0008180)3.07953171
33Abnormality of the vitamin B12 metabolism (HP:0004341)3.03297174
34Abnormality of renin-angiotensin system (HP:0000847)3.02474630
35Dehydration (HP:0001944)3.00647742
36Hypolipoproteinemia (HP:0010981)2.97031307
37Villous atrophy (HP:0011473)2.93710867
38Abnormality of small intestinal villus morphology (HP:0011472)2.93710867
39Increased purine levels (HP:0004368)2.92201469
40Hyperuricemia (HP:0002149)2.92201469
41Progressive sensorineural hearing impairment (HP:0000408)2.87523675
42Hypophosphatemia (HP:0002148)2.85882386
43Abnormal tarsal ossification (HP:0008369)2.83797669
44Abnormality of chloride homeostasis (HP:0011422)2.81930683
45Woolly hair (HP:0002224)2.81809451
46Rectal prolapse (HP:0002035)2.81614715
47Abnormal biliary tract morphology (HP:0012440)2.81502759
48Symphalangism affecting the phalanges of the hand (HP:0009773)2.81080296
49Metabolic alkalosis (HP:0200114)2.80325840
50Abnormality of vitamin B metabolism (HP:0004340)2.80141588
51Pustule (HP:0200039)2.78706926
52Hemorrhage of the eye (HP:0011885)2.78153418
53Megaloblastic anemia (HP:0001889)2.77905336
54Eczematoid dermatitis (HP:0000976)2.75908282
55Steatorrhea (HP:0002570)2.69901188
56Palpitations (HP:0001962)2.64011573
57Hyperammonemia (HP:0001987)2.60310394
58Short phalanx of the thumb (HP:0009660)2.59551703
59Glycosuria (HP:0003076)2.58022388
60Abnormality of urine glucose concentration (HP:0011016)2.58022388
61Potter facies (HP:0002009)2.56903277
62Facial shape deformation (HP:0011334)2.56903277
63Enlarged epiphyses (HP:0010580)2.55877514
64Syncope (HP:0001279)2.55059269
65Abnormality of carpal bone ossification (HP:0006257)2.54551771
66Flattened epiphyses (HP:0003071)2.53485688
67Milia (HP:0001056)2.53481403
68Pili torti (HP:0003777)2.53158929
69Abnormality of the gastric mucosa (HP:0004295)2.51115503
70Hypotension (HP:0002615)2.50181424
71Focal segmental glomerulosclerosis (HP:0000097)2.47828943
72Intrahepatic cholestasis (HP:0001406)2.47413382
73Fragile nails (HP:0001808)2.44792669
74Abnormality of monocarboxylic acid metabolism (HP:0010996)2.44760977
75Congenital sensorineural hearing impairment (HP:0008527)2.44720124
76Neonatal short-limb short stature (HP:0008921)2.43894094
77Hyperglycinuria (HP:0003108)2.43314444
78Delayed epiphyseal ossification (HP:0002663)2.43243729
79Progressive hearing impairment (HP:0001730)2.42809222
80Abnormal urine phosphate concentration (HP:0012599)2.38817616
81Abnormality of aspartate family amino acid metabolism (HP:0010899)2.37216362
82Micronodular cirrhosis (HP:0001413)2.35629076
83Abnormality of vitamin metabolism (HP:0100508)2.31688616
84Abnormality of nucleobase metabolism (HP:0010932)2.30520848
85Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.29061320
86Mesangial abnormality (HP:0001966)2.26751771
87Abnormality of the costochondral junction (HP:0000919)2.26598252
88Biliary tract neoplasm (HP:0100574)2.25610334
89Glomerulonephritis (HP:0000099)2.25101987
90Abnormal foot bone ossification (HP:0010675)2.24881470
91Bundle branch block (HP:0011710)2.24706602
92Hyperparathyroidism (HP:0000843)2.23881270
93Hoarse voice (HP:0001609)2.19993391
94Nephrolithiasis (HP:0000787)2.17634459
95Abnormal glucose tolerance (HP:0001952)2.17241935
96Protuberant abdomen (HP:0001538)2.17010307
97Xanthomatosis (HP:0000991)2.16753525
98Vertebral clefting (HP:0008428)2.14433012
99Increased IgE level (HP:0003212)2.13485061
100Abnormality of complement system (HP:0005339)2.13319325
101Hyperphosphatemia (HP:0002905)2.13065300
102Abnormal cartilage morphology (HP:0002763)2.12008756
103Gout (HP:0001997)2.11660570
104Subcapsular cataract (HP:0000523)2.11487554
105Posterior subcapsular cataract (HP:0007787)2.10339584
106Gingivitis (HP:0000230)2.10021236
107Metabolic acidosis (HP:0001942)2.08802946
108Renal tubular acidosis (HP:0001947)2.08207289
109Cone-rod dystrophy (HP:0000548)2.06730938
110Epidermoid cyst (HP:0200040)2.06645423
111Cerebral palsy (HP:0100021)2.04607932
112Pancreatitis (HP:0001733)2.04376373
113Complement deficiency (HP:0004431)2.04349338
114Ventricular fibrillation (HP:0001663)2.04013090
115Abnormal hand bone ossification (HP:0010660)2.03340540
116Wide cranial sutures (HP:0010537)2.03016919
117Hypercholesterolemia (HP:0003124)2.00926425
118Abnormality of the phalanges of the hallux (HP:0010057)2.00901161
119Increased mean platelet volume (HP:0011877)2.00202301
120Abnormality of dicarboxylic acid metabolism (HP:0010995)1.99635837
121Dicarboxylic aciduria (HP:0003215)1.99635837
122Myopathic facies (HP:0002058)1.99267771
123Curly hair (HP:0002212)1.98665303
124Nephritis (HP:0000123)1.98246279
125Flat capital femoral epiphysis (HP:0003370)1.97975147
126Abnormality of the 2nd finger (HP:0004100)1.97768764
127Ureteral stenosis (HP:0000071)1.96431981
128Alopecia of scalp (HP:0002293)1.96125878
129Thin bony cortex (HP:0002753)1.95056619
130Hyperphosphaturia (HP:0003109)1.93529046
131Abnormality of magnesium homeostasis (HP:0004921)1.92707659
132Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.92611412
133Fragile skin (HP:0001030)1.92046484
134Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.91684684
135Plantar hyperkeratosis (HP:0007556)1.90415425
136Abnormal vertebral ossification (HP:0100569)1.90375095
137Growth hormone excess (HP:0000845)1.90120598
138Abnormality of purine metabolism (HP:0004352)1.89483189
139Male infertility (HP:0003251)1.89464608
140Abnormality of the proximal phalanges of the hand (HP:0009834)1.87749916
141Atrophic scars (HP:0001075)1.87711302
142Glomerulosclerosis (HP:0000096)1.86485896
143Abnormal ossification of hand bones (HP:0005921)1.86463443
144Goiter (HP:0000853)1.84825732
145Multiple lipomas (HP:0001012)1.84617161
146Abnormality of pyrimidine metabolism (HP:0004353)1.83580852
147Segmental peripheral demyelination/remyelination (HP:0003481)1.79738347
148Irritability (HP:0000737)1.77458801
149Abnormality of sulfur amino acid metabolism (HP:0004339)1.76702781
150Abnormal enzyme/coenzyme activity (HP:0012379)1.73489410
151Abnormality of alkaline phosphatase activity (HP:0004379)1.73318760
152Symptomatic seizures (HP:0011145)1.72188924
153Hypokalemia (HP:0002900)1.72097343
154Hyperaldosteronism (HP:0000859)1.71086340

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B7.55997440
2FRK6.05118348
3LMTK25.69587823
4MST44.84111579
5MST1R4.54366911
6TAOK34.03298215
7PRKG23.31539700
8NME13.03810862
9EPHB22.85901747
10MAP2K22.74651968
11RIPK12.70897967
12GRK62.65213389
13FGFR42.22464018
14PIK3CA2.15436762
15EPHA22.04916496
16PTK62.00639719
17MAP3K21.96513964
18TESK11.81205436
19MAP3K101.80688994
20AKT31.76423999
21NUAK11.71971796
22TYK21.71198692
23EPHA31.66331406
24OXSR11.62578152
25MET1.53473608
26MYLK1.51245337
27TAOK11.51042163
28MAP4K11.47302413
29PRPF4B1.36519944
30KSR21.36357024
31ERN11.34928016
32TNIK1.21953427
33STK241.15830637
34FGFR31.15628705
35DDR21.12455710
36MATK1.08162675
37MAP3K71.06180887
38STK101.01324373
39EPHA40.99286617
40RIPK40.99055497
41MAP2K10.97444004
42PTK20.97421062
43ICK0.96675843
44PRKCI0.95002659
45ERBB20.92718735
46MAP3K90.92318184
47MAP3K80.87677278
48NLK0.85087299
49DMPK0.82777220
50TESK20.80126633
51FER0.79052627
52TTK0.78804729
53PAK40.78530573
54PRKAA20.76898592
55MAP2K60.74170264
56LATS10.72280096
57EPHB10.66980779
58MAP3K10.65447496
59LIMK10.63012884
60MAP3K110.60493198
61MAPK110.60211583
62IRAK10.58638318
63MAP3K120.57293644
64BMX0.56123693
65ERBB40.55923313
66JAK10.55395435
67CAMK2D0.53700681
68PIM10.51803802
69RET0.51753401
70PRKCZ0.51199929
71TRIB30.50956363
72BMPR20.50113645
73PDPK10.49052014
74PRKAA10.45830543
75JAK20.44891349
76YES10.44730736
77IKBKE0.44377706
78CSF1R0.44197465
79ZAP700.42491174
80PDK20.40894239
81SMG10.40544259
82AURKB0.39369611
83MAP3K140.39219575
84CSK0.38977205
85CDK190.38397221
86PAK10.38173027
87ABL20.37682450
88CASK0.37520680
89ARAF0.36105544
90SCYL20.36010017
91PAK30.34818009
92PDK10.34152643
93CDK60.33791995
94EEF2K0.33297250
95DYRK1B0.32566715
96PDK30.31982127
97PDK40.31982127
98SRC0.31605403
99STK390.31437525
100JAK30.31435555
101ROCK10.31350736
102CAMK2G0.31150476
103BTK0.31013423
104SYK0.30755473
105PRKCA0.30290574
106TBK10.30255904
107GRK10.29305177
108LRRK20.28617810
109CAMK2B0.27164592
110PBK0.26217076
111LYN0.26155953
112MELK0.24841038
113CSNK1A10.24389927
114IRAK40.23601907
115NEK60.23577276
116ITK0.23475964
117RPS6KA20.23296432
118PIM20.23032117
119KIT0.22723648
120MAP3K30.22283083
121STK110.21800134
122LCK0.21612207
123PAK20.21549497
124MAPKAPK20.20230649
125RPS6KB20.19872670
126WNK40.18508824
127PRKACG0.18507350
128CDC42BPA0.17657892
129STK30.17133836
130PRKCQ0.16835190
131FYN0.16678136
132PKN20.15634000
133CDK120.15184239
134BRAF0.14467266
135PDGFRA0.14160797
136AKT20.13605006
137FGR0.12096292
138NEK10.11577409
139PRKCD0.11175567
140MAP3K130.10470042

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049755.54852639
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.88934322
3Mineral absorption_Homo sapiens_hsa049784.33171714
4Renin-angiotensin system_Homo sapiens_hsa046144.00122215
5Sulfur metabolism_Homo sapiens_hsa009203.98928360
6Vitamin digestion and absorption_Homo sapiens_hsa049773.18014495
7Galactose metabolism_Homo sapiens_hsa000522.85215786
8Carbohydrate digestion and absorption_Homo sapiens_hsa049732.58255015
9Caffeine metabolism_Homo sapiens_hsa002322.54210811
10Bile secretion_Homo sapiens_hsa049762.41674205
11Starch and sucrose metabolism_Homo sapiens_hsa005002.30517077
12Protein digestion and absorption_Homo sapiens_hsa049742.06662706
13Fructose and mannose metabolism_Homo sapiens_hsa000512.05717101
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.02247900
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.98903131
16Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.95099539
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.88238265
18Histidine metabolism_Homo sapiens_hsa003401.77021098
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.71875937
20Folate biosynthesis_Homo sapiens_hsa007901.70792581
21Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.54557967
22PPAR signaling pathway_Homo sapiens_hsa033201.30778619
23Asthma_Homo sapiens_hsa053101.25217290
24Glycerolipid metabolism_Homo sapiens_hsa005611.23670127
25Glutathione metabolism_Homo sapiens_hsa004801.22673007
26Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.17687644
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.07838801
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07813642
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.07394918
30Tryptophan metabolism_Homo sapiens_hsa003801.06939324
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.04850973
32Sphingolipid metabolism_Homo sapiens_hsa006000.98910007
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97866668
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96252338
35Nitrogen metabolism_Homo sapiens_hsa009100.95804711
36Allograft rejection_Homo sapiens_hsa053300.93805617
37Tight junction_Homo sapiens_hsa045300.93057734
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91125505
39Pancreatic secretion_Homo sapiens_hsa049720.90026955
40Fatty acid degradation_Homo sapiens_hsa000710.88968352
41Phenylalanine metabolism_Homo sapiens_hsa003600.88622810
42Autoimmune thyroid disease_Homo sapiens_hsa053200.87167640
43Linoleic acid metabolism_Homo sapiens_hsa005910.85528094
44Graft-versus-host disease_Homo sapiens_hsa053320.83011020
45Arginine biosynthesis_Homo sapiens_hsa002200.80999991
46Staphylococcus aureus infection_Homo sapiens_hsa051500.80188980
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78873646
48ABC transporters_Homo sapiens_hsa020100.78463073
49Glycerophospholipid metabolism_Homo sapiens_hsa005640.77686468
50Thyroid hormone synthesis_Homo sapiens_hsa049180.76818965
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73509225
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72864700
53Arginine and proline metabolism_Homo sapiens_hsa003300.70811595
54Pentose phosphate pathway_Homo sapiens_hsa000300.68610136
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64987702
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64438678
57Type I diabetes mellitus_Homo sapiens_hsa049400.63406635
58Pyruvate metabolism_Homo sapiens_hsa006200.62245705
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.61310046
60Carbon metabolism_Homo sapiens_hsa012000.61161652
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60447952
62Other glycan degradation_Homo sapiens_hsa005110.59386852
63Gastric acid secretion_Homo sapiens_hsa049710.57358206
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56944056
65Salmonella infection_Homo sapiens_hsa051320.52251074
66Chemical carcinogenesis_Homo sapiens_hsa052040.51826533
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.49928352
68Arachidonic acid metabolism_Homo sapiens_hsa005900.49298685
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.49246737
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.45604169
71Salivary secretion_Homo sapiens_hsa049700.45407685
72Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44918368
73Antigen processing and presentation_Homo sapiens_hsa046120.44786347
74Thyroid cancer_Homo sapiens_hsa052160.44617530
75Adherens junction_Homo sapiens_hsa045200.43394768
76Peroxisome_Homo sapiens_hsa041460.43275016
77Ether lipid metabolism_Homo sapiens_hsa005650.42013602
78Type II diabetes mellitus_Homo sapiens_hsa049300.41080375
79Leishmaniasis_Homo sapiens_hsa051400.39657546
80Butanoate metabolism_Homo sapiens_hsa006500.38809670
81Tyrosine metabolism_Homo sapiens_hsa003500.35857981
82Hepatitis C_Homo sapiens_hsa051600.35426626
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35141564
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.35132385
85beta-Alanine metabolism_Homo sapiens_hsa004100.34820140
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.34542077
87African trypanosomiasis_Homo sapiens_hsa051430.34064932
88Bladder cancer_Homo sapiens_hsa052190.33249216
89Retinol metabolism_Homo sapiens_hsa008300.31520519
90Sulfur relay system_Homo sapiens_hsa041220.31416994
91Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.26884845
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26080783
93Metabolic pathways_Homo sapiens_hsa011000.25345053
94Vibrio cholerae infection_Homo sapiens_hsa051100.23685405
95Pertussis_Homo sapiens_hsa051330.23503383
96Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.23037809
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.22357829
98Viral myocarditis_Homo sapiens_hsa054160.22135334
99Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.21977813
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.21921237
101Primary bile acid biosynthesis_Homo sapiens_hsa001200.19949307
102Cocaine addiction_Homo sapiens_hsa050300.19499682
103Insulin secretion_Homo sapiens_hsa049110.19234652
104Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.18814632
105Steroid biosynthesis_Homo sapiens_hsa001000.18647672
106GnRH signaling pathway_Homo sapiens_hsa049120.18511914
107Alzheimers disease_Homo sapiens_hsa050100.17504753
108Fatty acid metabolism_Homo sapiens_hsa012120.17217191
109Glucagon signaling pathway_Homo sapiens_hsa049220.16753033
110Toxoplasmosis_Homo sapiens_hsa051450.15777255
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.14906670
112Renin secretion_Homo sapiens_hsa049240.14887044
113Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.14845330
114Selenocompound metabolism_Homo sapiens_hsa004500.13414978
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.12754265
116Hematopoietic cell lineage_Homo sapiens_hsa046400.11648949
117Inositol phosphate metabolism_Homo sapiens_hsa005620.09726560
118Biosynthesis of amino acids_Homo sapiens_hsa012300.09337624
119Choline metabolism in cancer_Homo sapiens_hsa052310.09203660
120Fatty acid biosynthesis_Homo sapiens_hsa000610.09147135
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.09024424
122Influenza A_Homo sapiens_hsa051640.06067437
123Tuberculosis_Homo sapiens_hsa051520.05565513
124Insulin resistance_Homo sapiens_hsa049310.05447354
125Chemokine signaling pathway_Homo sapiens_hsa040620.04802760
126Endometrial cancer_Homo sapiens_hsa052130.04709655
127Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.04660256
128NOD-like receptor signaling pathway_Homo sapiens_hsa046210.04481751
129Amphetamine addiction_Homo sapiens_hsa050310.04426340
130Oxidative phosphorylation_Homo sapiens_hsa001900.04185823
131Gap junction_Homo sapiens_hsa045400.04018131
132Amoebiasis_Homo sapiens_hsa051460.03542640

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