MYO15B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)9.72186476
2intestinal cholesterol absorption (GO:0030299)8.87765583
3angiotensin maturation (GO:0002003)8.06413894
4actin filament depolymerization (GO:0030042)6.16948859
5flavonoid metabolic process (GO:0009812)5.81419929
63-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)5.70503907
7purine ribonucleoside bisphosphate metabolic process (GO:0034035)5.70503907
8UDP-N-acetylglucosamine metabolic process (GO:0006047)5.68814429
9drug catabolic process (GO:0042737)5.41766792
10bile acid and bile salt transport (GO:0015721)5.38105592
11maintenance of gastrointestinal epithelium (GO:0030277)5.37101520
12bundle of His cell to Purkinje myocyte communication (GO:0086069)5.35870847
13regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.31212631
14sulfate transmembrane transport (GO:1902358)5.31080706
15vitamin A metabolic process (GO:0006776)5.18764011
16regulation of bile acid biosynthetic process (GO:0070857)5.07371601
17intestinal epithelial cell development (GO:0060576)5.05927069
18digestive system process (GO:0022600)4.88821538
19negative regulation of erythrocyte differentiation (GO:0045647)4.77195257
20response to hepatocyte growth factor (GO:0035728)4.73381721
21cellular response to hepatocyte growth factor stimulus (GO:0035729)4.73381721
22sulfur compound transport (GO:0072348)4.53369331
23positive regulation of gamma-delta T cell activation (GO:0046645)4.38029123
24sulfate transport (GO:0008272)4.34141517
25modified amino acid transport (GO:0072337)4.33098010
26glucose 6-phosphate metabolic process (GO:0051156)4.32214765
27adhesion of symbiont to host cell (GO:0044650)4.31191159
28virion attachment to host cell (GO:0019062)4.31191159
29antigen processing and presentation of endogenous antigen (GO:0019883)4.31186721
30epithelial structure maintenance (GO:0010669)4.23017420
31antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.22506548
32mannose metabolic process (GO:0006013)4.20039573
33digestion (GO:0007586)4.13181205
34drug transmembrane transport (GO:0006855)4.09358746
35regulation of cholesterol homeostasis (GO:2000188)4.05666024
36O-glycan processing (GO:0016266)4.03035231
37bicarbonate transport (GO:0015701)4.00645478
38antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.99138910
39drug transport (GO:0015893)3.96144302
40negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.91822702
41negative regulation of cell killing (GO:0031342)3.91822702
42sulfation (GO:0051923)3.90968567
43regulation of gamma-delta T cell activation (GO:0046643)3.83771386
44antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.82539108
45regulation of gamma-delta T cell differentiation (GO:0045586)3.79958333
46detection of bacterium (GO:0016045)3.79339997
47detection of other organism (GO:0098543)3.75012621
48exogenous drug catabolic process (GO:0042738)3.73459497
49hormone catabolic process (GO:0042447)3.70965464
50lipoprotein metabolic process (GO:0042157)3.70086185
51transcytosis (GO:0045056)3.69107033
52phospholipid efflux (GO:0033700)3.59577560
53regulation of guanylate cyclase activity (GO:0031282)3.59267346
54desmosome organization (GO:0002934)3.57011443
55calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.48908083
56hemidesmosome assembly (GO:0031581)3.48201890
57peptide hormone processing (GO:0016486)3.46467264
58regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.45727174
59striated muscle atrophy (GO:0014891)3.44686639
60cGMP-mediated signaling (GO:0019934)3.43968731
61adhesion of symbiont to host (GO:0044406)3.36832041
62oligosaccharide catabolic process (GO:0009313)3.36231949
63lipoprotein transport (GO:0042953)3.34844606
64peptide catabolic process (GO:0043171)3.32954810
65sulfur amino acid catabolic process (GO:0000098)3.29835262
66renal absorption (GO:0070293)3.28636380
67sperm capacitation (GO:0048240)3.28067558
68response to peptidoglycan (GO:0032494)3.25624030
69macrophage activation involved in immune response (GO:0002281)3.25621565
70plasma lipoprotein particle assembly (GO:0034377)3.25469209
71regulation of actin nucleation (GO:0051125)3.25067336
72thrombin receptor signaling pathway (GO:0070493)3.24840729
73positive thymic T cell selection (GO:0045059)3.23877180
74regulation of dendritic cell antigen processing and presentation (GO:0002604)3.23216123
75germinal center formation (GO:0002467)3.21378842
76immunoglobulin mediated immune response (GO:0016064)3.20759176
77negative regulation of keratinocyte proliferation (GO:0010839)3.20666818
78response to muramyl dipeptide (GO:0032495)3.20647317
79cholesterol homeostasis (GO:0042632)3.19530488
80sterol homeostasis (GO:0055092)3.19444482
81regulation of viral release from host cell (GO:1902186)3.19294053
82negative regulation of sterol transport (GO:0032372)3.18936665
83negative regulation of cholesterol transport (GO:0032375)3.18936665
84thyroid hormone metabolic process (GO:0042403)3.16619081
85neutrophil activation involved in immune response (GO:0002283)3.16354261
86positive regulation of lipoprotein lipase activity (GO:0051006)3.15304946
87positive regulation of triglyceride lipase activity (GO:0061365)3.15304946
88pyrimidine-containing compound transmembrane transport (GO:0072531)3.14886391
89modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.14495332
90positive regulation by organism of defense response of other organism involved in symbiotic interact3.14495332
91modulation by symbiont of host immune response (GO:0052553)3.14495332
92positive regulation by symbiont of host defense response (GO:0052509)3.14495332
93modulation by symbiont of host defense response (GO:0052031)3.14495332
94modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.14495332
95nucleotide-sugar biosynthetic process (GO:0009226)3.13362894
96regulation of myeloid leukocyte mediated immunity (GO:0002886)3.13324144
97phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.12313807
98negative regulation of granulocyte differentiation (GO:0030853)3.12262641
99protein-lipid complex assembly (GO:0065005)3.11884759
100positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.09441920
101hepatocyte apoptotic process (GO:0097284)3.07763212
102triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.06889511
103vitamin transmembrane transport (GO:0035461)3.05553187
104regulation of cellular extravasation (GO:0002691)3.05061844
105phosphatidylcholine biosynthetic process (GO:0006656)3.01968392
106epithelial cell-cell adhesion (GO:0090136)3.00323578
107cytidine metabolic process (GO:0046087)2.99981070
108cytidine catabolic process (GO:0006216)2.99981070
109cytidine deamination (GO:0009972)2.99981070
110transepithelial transport (GO:0070633)2.97706061
111regulation of mast cell degranulation (GO:0043304)2.97539776
112regulation of triglyceride catabolic process (GO:0010896)2.97499574
113skeletal muscle adaptation (GO:0043501)2.97120007
114antibacterial humoral response (GO:0019731)2.96119051
115positive regulation of Cdc42 GTPase activity (GO:0043089)2.95808232
116regulation of cholesterol esterification (GO:0010872)2.95639228
117regulation of leukocyte degranulation (GO:0043300)2.95070399
118regulation of systemic arterial blood pressure by hormone (GO:0001990)2.93892158
119regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.93892158
120endocrine process (GO:0050886)2.93892158
121antimicrobial humoral response (GO:0019730)2.93447941
122detection of external biotic stimulus (GO:0098581)2.93036653
123phospholipid scrambling (GO:0017121)2.92546029
124diacylglycerol metabolic process (GO:0046339)2.91732591
125cellular glucuronidation (GO:0052695)2.90298747
126ribonucleoside bisphosphate metabolic process (GO:0033875)2.88114265
127nucleoside bisphosphate metabolic process (GO:0033865)2.88114265
128purine nucleoside bisphosphate metabolic process (GO:0034032)2.88114265
129very-low-density lipoprotein particle assembly (GO:0034379)2.88104675
130drug metabolic process (GO:0017144)2.85549554
131muscle atrophy (GO:0014889)2.82774260
132cellular extravasation (GO:0045123)2.81960188
133vitamin transport (GO:0051180)2.80431949
134regulation of interferon-beta biosynthetic process (GO:0045357)2.78944530
135nucleotide-sugar metabolic process (GO:0009225)2.78425760
136receptor guanylyl cyclase signaling pathway (GO:0007168)2.77409134
137regulation of vitamin metabolic process (GO:0030656)2.76994963
138positive regulation of T cell differentiation in thymus (GO:0033089)2.75255445
139thymic T cell selection (GO:0045061)2.75195205
140negative regulation of interleukin-8 production (GO:0032717)2.73552664
141positive regulation of Rap GTPase activity (GO:0032854)2.72991753
142positive regulation of B cell differentiation (GO:0045579)2.71890519
143regulation of mast cell activation involved in immune response (GO:0033006)2.71280446
144T cell selection (GO:0045058)2.70177199
145regulation of ARF GTPase activity (GO:0032312)2.68337032
146negative thymic T cell selection (GO:0045060)2.66673343
147positive regulation of antigen processing and presentation (GO:0002579)2.64466446
148B cell receptor signaling pathway (GO:0050853)2.62629174
149detection of biotic stimulus (GO:0009595)2.59790762
150regulation of antigen processing and presentation (GO:0002577)2.56641929
151negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.53313625
152regulation of B cell receptor signaling pathway (GO:0050855)2.49827631
153negative regulation of lymphocyte mediated immunity (GO:0002707)2.46133713
154negative regulation of myotube differentiation (GO:0010832)2.45269874
155positive T cell selection (GO:0043368)2.45056811
156leukocyte aggregation (GO:0070486)2.44861868
157interferon-gamma-mediated signaling pathway (GO:0060333)2.44604756
158negative T cell selection (GO:0043383)2.44442988
159regulation of T-helper 2 cell differentiation (GO:0045628)2.44349308
160regulation of tolerance induction (GO:0002643)2.42270278
161positive regulation of histone deacetylation (GO:0031065)2.40669999
162neutrophil activation (GO:0042119)2.40653812
163regulation of regulated secretory pathway (GO:1903305)2.40006898
164macrophage activation (GO:0042116)2.38898163
165negative regulation of leukocyte mediated immunity (GO:0002704)2.38541984
166leukotriene metabolic process (GO:0006691)2.38526129
167regulation of granulocyte differentiation (GO:0030852)2.36908636
168antigen processing and presentation via MHC class Ib (GO:0002475)2.36787954
169cellular response to exogenous dsRNA (GO:0071360)2.34361173
170positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.34219420
171defense response to protozoan (GO:0042832)2.33733385
172regulation of extracellular matrix disassembly (GO:0010715)2.31770330
173response to type I interferon (GO:0034340)2.30938517
174regulation of necroptotic process (GO:0060544)2.30813092
175glycosphingolipid catabolic process (GO:0046479)2.30542177
176regulation of B cell differentiation (GO:0045577)2.29997319
177regulation of T cell tolerance induction (GO:0002664)2.28793119
178negative regulation of interleukin-12 production (GO:0032695)2.28110749
179negative regulation of innate immune response (GO:0045824)2.27791636
180NIK/NF-kappaB signaling (GO:0038061)2.27758297
181histone H3-K36 demethylation (GO:0070544)2.26219187
182dendritic cell chemotaxis (GO:0002407)2.25847561
183positive regulation of protein deacetylation (GO:0090312)2.25607544
184regulation of respiratory burst (GO:0060263)2.22881607
185negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.22697247
186negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.22534709
187type I interferon signaling pathway (GO:0060337)2.22420163
188cellular response to type I interferon (GO:0071357)2.22420163
189mature B cell differentiation involved in immune response (GO:0002313)2.22236639
190cellular response to reactive nitrogen species (GO:1902170)2.22048875

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.35678788
2CDX2_20551321_ChIP-Seq_CACO-2_Human5.33231231
3SOX2_27498859_Chip-Seq_STOMACH_Mouse3.84825646
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.73109572
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.03290574
6VDR_21846776_ChIP-Seq_THP-1_Human2.96937184
7HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.90759083
8GATA4_25053715_ChIP-Seq_YYC3_Human2.89531981
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.87781598
10GATA6_25053715_ChIP-Seq_YYC3_Human2.82374226
11SOX2_20726797_ChIP-Seq_SW620_Human2.82358941
12PPARA_22158963_ChIP-Seq_LIVER_Mouse2.76839495
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.75205153
14CDX2_19796622_ChIP-Seq_MESCs_Mouse2.68678083
15SRY_22984422_ChIP-ChIP_TESTIS_Rat2.65208971
16KDM2B_26808549_Chip-Seq_SUP-B15_Human2.58799543
17RXR_22158963_ChIP-Seq_LIVER_Mouse2.45870477
18VDR_24763502_ChIP-Seq_THP-1_Human2.44575696
19TCF7_22412390_ChIP-Seq_EML_Mouse2.32792019
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.32128783
21LXR_22158963_ChIP-Seq_LIVER_Mouse2.31745446
22KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.19700977
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.18502263
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.12546290
25* KDM2B_26808549_Chip-Seq_DND41_Human2.09657793
26SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.07609435
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.05070594
28MYC_22102868_ChIP-Seq_BL_Human2.04129100
29TRIM28_21343339_ChIP-Seq_HEK293_Human2.01313917
30SCL_19346495_ChIP-Seq_HPC-7_Human2.00720830
31SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98950606
32STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.97827826
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.96800747
34* ELK3_25401928_ChIP-Seq_HUVEC_Human1.95665078
35CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.95316193
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.91950333
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.87870113
38PPAR_26484153_Chip-Seq_NCI-H1993_Human1.85771065
39KLF5_25053715_ChIP-Seq_YYC3_Human1.83614221
40ESR1_21235772_ChIP-Seq_MCF-7_Human1.78404289
41NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.77397779
42PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.76645581
43SPI1_23127762_ChIP-Seq_K562_Human1.73920910
44RUNX1_22412390_ChIP-Seq_EML_Mouse1.73711329
45RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.73065592
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.72656433
47MAF_26560356_Chip-Seq_TH1_Human1.71175274
48ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.70302093
49* RACK7_27058665_Chip-Seq_MCF-7_Human1.69898897
50IRF8_27001747_Chip-Seq_BMDM_Mouse1.69176979
51IRF8_21731497_ChIP-ChIP_J774_Mouse1.68965229
52UTX_26944678_Chip-Seq_JUKART_Human1.68615705
53NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.68491848
54KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.67107034
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.66432800
56TCF4_18268006_ChIP-ChIP_LS174T_Human1.64959062
57FOXO3_23340844_ChIP-Seq_DLD1_Human1.62244046
58KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.60253181
59RUNX_20019798_ChIP-Seq_JUKART_Human1.57761162
60* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.56834939
61* RUNX1_27514584_Chip-Seq_MCF-7_Human1.55751626
62GATA1_19941827_ChIP-Seq_MEL_Mouse1.54661671
63NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52140059
64BRD4_27068464_Chip-Seq_AML-cells_Mouse1.49974775
65FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.48809721
66ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.46007784
67GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.45401545
68KDM2B_26808549_Chip-Seq_K562_Human1.44123335
69CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.43777433
70RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.43685247
71STAT6_21828071_ChIP-Seq_BEAS2B_Human1.43292470
72ATF3_27146783_Chip-Seq_COLON_Human1.42402887
73P68_20966046_ChIP-Seq_HELA_Human1.41981992
74NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.41733547
75FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.40463430
76MAF_26560356_Chip-Seq_TH2_Human1.39783256
77TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39574767
78ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.39505135
79BCL6_27268052_Chip-Seq_Bcells_Human1.38292259
80BCOR_27268052_Chip-Seq_Bcells_Human1.38135022
81VDR_22108803_ChIP-Seq_LS180_Human1.36944697
82MYB_21317192_ChIP-Seq_ERMYB_Mouse1.36848830
83* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.35205142
84SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.31766650
85RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31376261
86EGR1_23403033_ChIP-Seq_LIVER_Mouse1.30173326
87HNF4A_19822575_ChIP-Seq_HepG2_Human1.28209630
88* KDM2B_26808549_Chip-Seq_JURKAT_Human1.28135819
89* SA1_27219007_Chip-Seq_ERYTHROID_Human1.25752412
90SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25133122
91NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.24259269
92SMC4_20622854_ChIP-Seq_HELA_Human1.24070610
93GATA2_19941826_ChIP-Seq_K562_Human1.23800978
94STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.23297168
95GATA1_22383799_ChIP-Seq_G1ME_Mouse1.23227562
96BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.22856852
97FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.22574441
98DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22377347
99TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22097637
100EGR1_19374776_ChIP-ChIP_THP-1_Human1.21659011
101GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.20380631
102CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.20308406
103* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19774028
104VDR_24787735_ChIP-Seq_THP-1_Human1.19760134
105ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.18799895
106SPI1_23547873_ChIP-Seq_NB4_Human1.18592749
107EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.18490768
108ESR1_20079471_ChIP-ChIP_T-47D_Human1.17893286
109MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.17765660
110MYB_26560356_Chip-Seq_TH1_Human1.17419776
111PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16513777
112FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.16150589
113MYB_26560356_Chip-Seq_TH2_Human1.15970636
114FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.15195490
115RARG_19884340_ChIP-ChIP_MEFs_Mouse1.15011799
116LXR_22292898_ChIP-Seq_THP-1_Human1.14769528
117FOXA2_19822575_ChIP-Seq_HepG2_Human1.13701296
118TET1_21451524_ChIP-Seq_MESCs_Mouse1.12784878
119TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12608840
120KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12325316
121CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11902799
122STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11778329
123CLOCK_20551151_ChIP-Seq_293T_Human1.09939851
124AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.08423809
125GATA2_21666600_ChIP-Seq_HMVEC_Human1.07644875
126PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.06929881
127MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06612675
128LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06260299
129JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05596523
130ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05543962
131GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05310630
132GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05000458
133ELF1_20517297_ChIP-Seq_JURKAT_Human1.04732619
134CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04667786
135* CREB1_26743006_Chip-Seq_LNCaP_Human1.04536385
136GATA1_22025678_ChIP-Seq_K562_Human1.04093726
137DROSHA_22980978_ChIP-Seq_HELA_Human1.02282377
138FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.98837741
139PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.97769288
140SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.97489077
141SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.97489077
142AR_21909140_ChIP-Seq_LNCAP_Human0.97450903
143EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97416608
144EGR1_19032775_ChIP-ChIP_M12_Human0.96066333
145TCF3_18692474_ChIP-Seq_MEFs_Mouse0.94661639
146GATA3_24758297_ChIP-Seq_MCF-7_Human0.93274370
147SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92409388
148HIF1A_21447827_ChIP-Seq_MCF-7_Human0.91792849
149SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.91474004
150FOXA1_25552417_ChIP-Seq_VCAP_Human0.90929118
151CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.90855605
152ZNF263_19887448_ChIP-Seq_K562_Human0.89416429
153P63_26484246_Chip-Seq_KERATINOCYTES_Human0.88628532
154EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88600642
155GATA1_26923725_Chip-Seq_HPCs_Mouse0.88314307
156PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.87053374
157TP63_22573176_ChIP-Seq_HFKS_Human0.85757266
158CTCF_27219007_Chip-Seq_Bcells_Human0.85696141
159POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.85344366
160GATA1_19941826_ChIP-Seq_K562_Human0.84441440
161CTNNB1_20460455_ChIP-Seq_HCT116_Human0.82582971
162UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.82264315
163SMAD3_21741376_ChIP-Seq_HESCs_Human0.82073803
164SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.81731473
165RARA_24833708_ChIP-Seq_LIVER_Mouse0.80012698
166CDX2_22108803_ChIP-Seq_LS180_Human0.78934604
167P300_27058665_Chip-Seq_ZR-75-30cells_Human0.78778833
168IKZF1_21737484_ChIP-ChIP_HCT116_Human0.78729942
169MYC_19915707_ChIP-ChIP_AK7_Human0.77327571
170FOXM1_26456572_ChIP-Seq_MCF-7_Human0.75378654
171OCT4_18692474_ChIP-Seq_MEFs_Mouse0.74235670

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.24642653
2MP0010234_abnormal_vibrissa_follicle5.75827084
3MP0001666_abnormal_nutrient_absorption5.13758853
4MP0004264_abnormal_extraembryonic_tissu4.05063384
5MP0003866_abnormal_defecation3.44327020
6MP0005377_hearing/vestibular/ear_phenot3.42546227
7MP0003878_abnormal_ear_physiology3.42546227
8MP0003436_decreased_susceptibility_to3.36667798
9MP0002822_catalepsy3.31358819
10MP0000462_abnormal_digestive_system3.29617876
11MP0005085_abnormal_gallbladder_physiolo3.14281180
12MP0003303_peritoneal_inflammation2.95047134
13MP0003724_increased_susceptibility_to2.90921225
14MP0002139_abnormal_hepatobiliary_system2.84336180
15MP0008875_abnormal_xenobiotic_pharmacok2.83167702
16MP0003252_abnormal_bile_duct2.64502739
17MP0003283_abnormal_digestive_organ2.62197898
18MP0003172_abnormal_lysosome_physiology2.61755046
19MP0004043_abnormal_pH_regulation2.59044579
20MP0001835_abnormal_antigen_presentation2.57915619
21MP0005058_abnormal_lysosome_morphology2.41282405
22MP0003183_abnormal_peptide_metabolism2.29280650
23MP0005381_digestive/alimentary_phenotyp2.25776146
24MP0001663_abnormal_digestive_system2.24345471
25MP0009840_abnormal_foam_cell2.21033120
26MP0005025_abnormal_response_to2.20791090
27MP0004019_abnormal_vitamin_homeostasis2.18543299
28MP0002419_abnormal_innate_immunity2.17627200
29MP0001873_stomach_inflammation2.12502896
30MP0005365_abnormal_bile_salt2.11229539
31MP0005409_darkened_coat_color2.08337213
32MP0001790_abnormal_immune_system2.07275094
33MP0005387_immune_system_phenotype2.07275094
34MP0010155_abnormal_intestine_physiology2.05470580
35MP0001800_abnormal_humoral_immune2.05309260
36MP0000538_abnormal_urinary_bladder2.00097869
37MP0009278_abnormal_bone_marrow1.96031416
38MP0010352_gastrointestinal_tract_polyps1.92318523
39MP0001664_abnormal_digestion1.91848586
40MP0003300_gastrointestinal_ulcer1.90691147
41MP0000477_abnormal_intestine_morphology1.86568128
42MP0005000_abnormal_immune_tolerance1.84514847
43MP0010329_abnormal_lipoprotein_level1.82330351
44MP0000490_abnormal_crypts_of1.79414259
45MP0000685_abnormal_immune_system1.76587402
46MP0009785_altered_susceptibility_to1.73505505
47MP0005167_abnormal_blood-brain_barrier1.73367618
48MP0003705_abnormal_hypodermis_morpholog1.73013302
49MP0002723_abnormal_immune_serum1.72809932
50MP0008260_abnormal_autophagy1.72251121
51MP0002452_abnormal_antigen_presenting1.71093253
52MP0001819_abnormal_immune_cell1.70177440
53MP0002420_abnormal_adaptive_immunity1.69744369
54MP0006082_CNS_inflammation1.69725230
55MP0000537_abnormal_urethra_morphology1.69220259
56MP0009643_abnormal_urine_homeostasis1.68037088
57MP0002396_abnormal_hematopoietic_system1.64490111
58MP0005671_abnormal_response_to1.63804941
59MP0003763_abnormal_thymus_physiology1.63767731
60MP0001533_abnormal_skeleton_physiology1.63601096
61MP0002796_impaired_skin_barrier1.63456831
62MP0001765_abnormal_ion_homeostasis1.63216880
63MP0003315_abnormal_perineum_morphology1.60266962
64MP0005084_abnormal_gallbladder_morpholo1.60250932
65MP0003191_abnormal_cellular_cholesterol1.58749586
66MP0004147_increased_porphyrin_level1.53554576
67MP0005464_abnormal_platelet_physiology1.52402118
68MP0002166_altered_tumor_susceptibility1.50367411
69MP0005670_abnormal_white_adipose1.48266483
70MP0002148_abnormal_hypersensitivity_rea1.44410460
71MP0002998_abnormal_bone_remodeling1.41608134
72MP0000465_gastrointestinal_hemorrhage1.38952641
73MP0001545_abnormal_hematopoietic_system1.38270245
74MP0005397_hematopoietic_system_phenotyp1.38270245
75MP0002933_joint_inflammation1.36220421
76MP0000716_abnormal_immune_system1.31805260
77MP0003828_pulmonary_edema1.31603688
78MP0002405_respiratory_system_inflammati1.27133614
79MP0001849_ear_inflammation1.27112414
80MP0005076_abnormal_cell_differentiation1.24492900
81MP0002132_abnormal_respiratory_system1.24297711
82MP0002398_abnormal_bone_marrow1.22910947
83MP0005636_abnormal_mineral_homeostasis1.22141860
84MP0010678_abnormal_skin_adnexa1.18521076
85MP0009333_abnormal_splenocyte_physiolog1.18274754
86MP0003868_abnormal_feces_composition1.18045959
87MP0005332_abnormal_amino_acid1.17251632
88MP0008469_abnormal_protein_level1.16271675
89MP0008004_abnormal_stomach_pH1.13785918
90MP0003806_abnormal_nucleotide_metabolis1.12992857
91MP0002876_abnormal_thyroid_physiology1.12433925
92MP0006054_spinal_hemorrhage1.09395360
93MP0002009_preneoplasia1.08575193
94MP0004510_myositis1.03766619
95MP0003879_abnormal_hair_cell1.03143566
96MP0002429_abnormal_blood_cell1.02858351
97MP0000249_abnormal_blood_vessel1.02304290
98MP0005501_abnormal_skin_physiology1.01844293
99MP0009115_abnormal_fat_cell1.00434133
100MP0003279_aneurysm0.99055394
101MP0004947_skin_inflammation0.99045926
102MP0002136_abnormal_kidney_physiology0.97130515
103MP0001851_eye_inflammation0.96452778
104MP0005535_abnormal_body_temperature0.95915836
105MP0002722_abnormal_immune_system0.94917819
106MP0003690_abnormal_glial_cell0.93844165
107MP0002118_abnormal_lipid_homeostasis0.92363743
108MP0005310_abnormal_salivary_gland0.92204730
109MP0000467_abnormal_esophagus_morphology0.92095594
110MP0002098_abnormal_vibrissa_morphology0.91994124
111MP0005448_abnormal_energy_balance0.91871024
112MP0001986_abnormal_taste_sensitivity0.91480643
113MP0002971_abnormal_brown_adipose0.91050318
114MP0000858_altered_metastatic_potential0.90798360
115MP0000689_abnormal_spleen_morphology0.90566482
116MP0005375_adipose_tissue_phenotype0.89204913
117MP0001958_emphysema0.88202770
118MP0003091_abnormal_cell_migration0.87803851
119MP0001756_abnormal_urination0.86275688
120MP0003075_altered_response_to0.86113465
121MP0002089_abnormal_postnatal_growth/wei0.84597670
122MP0004381_abnormal_hair_follicle0.83938005
123MP0009764_decreased_sensitivity_to0.83304769
124MP0000609_abnormal_liver_physiology0.82743421
125MP0005166_decreased_susceptibility_to0.82641140
126MP0003453_abnormal_keratinocyte_physiol0.81119516
127MP0000678_abnormal_parathyroid_gland0.80697887
128MP0005390_skeleton_phenotype0.79872429
129MP0009780_abnormal_chondrocyte_physiolo0.77841174
130MP0000470_abnormal_stomach_morphology0.77375821
131MP0002254_reproductive_system_inflammat0.75066050
132MP0009384_cardiac_valve_regurgitation0.73342312
133MP0001216_abnormal_epidermal_layer0.71932089
134MP0009379_abnormal_foot_pigmentation0.71377399
135MP0009053_abnormal_anal_canal0.70919445
136MP0005319_abnormal_enzyme/_coenzyme0.68612968
137MP0008872_abnormal_physiological_respon0.67375888
138MP0002138_abnormal_hepatobiliary_system0.65609314
139MP0003941_abnormal_skin_development0.61769654
140MP0005367_renal/urinary_system_phenotyp0.57040443
141MP0000516_abnormal_urinary_system0.57040443
142MP0005584_abnormal_enzyme/coenzyme_acti0.54787411
143MP0005451_abnormal_body_composition0.53478007
144MP0001764_abnormal_homeostasis0.52562225
145MP0008961_abnormal_basal_metabolism0.51581126
146MP0009642_abnormal_blood_homeostasis0.50359065
147MP0004782_abnormal_surfactant_physiolog0.47358022
148MP0000613_abnormal_salivary_gland0.47226687
149MP0004858_abnormal_nervous_system0.46720992
150MP0005266_abnormal_metabolism0.45988544
151MP0004185_abnormal_adipocyte_glucose0.45752256
152MP0002060_abnormal_skin_morphology0.45407106
153MP0000377_abnormal_hair_follicle0.44140582
154MP0003638_abnormal_response/metabolism_0.42480958
155MP0000230_abnormal_systemic_arterial0.40868761
156MP0005023_abnormal_wound_healing0.40742462
157MP0008873_increased_physiological_sensi0.40676815
158MP0002277_abnormal_respiratory_mucosa0.40267879
159MP0004270_analgesia0.40094277
160MP0002234_abnormal_pharynx_morphology0.39973715
161MP0002896_abnormal_bone_mineralization0.39760425
162MP0005666_abnormal_adipose_tissue0.39698183
163MP0003045_fibrosis0.39612764
164MP0001845_abnormal_inflammatory_respons0.37046665
165MP0001485_abnormal_pinna_reflex0.36900774

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)7.10541733
2Abnormality of glutamine family amino acid metabolism (HP:0010902)5.45021162
3Hyperactive renin-angiotensin system (HP:0000841)5.32257770
4Right ventricular cardiomyopathy (HP:0011663)5.27801475
5Malnutrition (HP:0004395)5.01478346
6Eczematoid dermatitis (HP:0000976)4.72764443
7Metabolic alkalosis (HP:0200114)4.60239529
8Cupped ribs (HP:0000887)4.48445431
9Flat acetabular roof (HP:0003180)4.47760758
10Acanthocytosis (HP:0001927)4.40893549
11Abdominal distention (HP:0003270)4.32321699
12Abnormality of chloride homeostasis (HP:0011422)4.15991070
13Hydroxyprolinuria (HP:0003080)4.14153677
14Abnormality of proline metabolism (HP:0010907)4.14153677
15Conjugated hyperbilirubinemia (HP:0002908)3.98863750
16Abnormal tarsal ossification (HP:0008369)3.86006538
17Systemic lupus erythematosus (HP:0002725)3.81614671
18Hypobetalipoproteinemia (HP:0003563)3.81414067
19Widely patent fontanelles and sutures (HP:0004492)3.47774899
20Chronic diarrhea (HP:0002028)3.44628516
21Abnormality of the 1st metacarpal (HP:0010009)3.44277599
22Colitis (HP:0002583)3.42738062
23Recurrent abscess formation (HP:0002722)3.35305949
24Dehydration (HP:0001944)3.33407734
25Fat malabsorption (HP:0002630)3.31243554
26Recurrent bacterial skin infections (HP:0005406)3.28489300
27Myositis (HP:0100614)3.28487789
28Gingivitis (HP:0000230)3.27136656
29Abnormality of renin-angiotensin system (HP:0000847)3.24855597
30Abnormality of small intestinal villus morphology (HP:0011472)3.24340470
31Villous atrophy (HP:0011473)3.24340470
32Abnormality of macrophages (HP:0004311)3.19484829
33Obstructive sleep apnea (HP:0002870)3.17392347
34Gastrointestinal dysmotility (HP:0002579)3.09410552
35Autoimmune thrombocytopenia (HP:0001973)3.06399291
36Abnormal delayed hypersensitivity skin test (HP:0002963)3.03466798
37Abnormality of carpal bone ossification (HP:0006257)3.01660921
38Recurrent fungal infections (HP:0002841)3.01423651
39Increased IgE level (HP:0003212)2.97819072
40Elevated erythrocyte sedimentation rate (HP:0003565)2.94245468
41Inflammation of the large intestine (HP:0002037)2.94030859
42Abnormality of the vitamin B12 metabolism (HP:0004341)2.93398709
43Gastrointestinal inflammation (HP:0004386)2.93002496
44Hemorrhage of the eye (HP:0011885)2.91100125
45Recurrent gram-negative bacterial infections (HP:0005420)2.89848947
46Pustule (HP:0200039)2.88173243
47Abnormality of the fingertips (HP:0001211)2.82223919
48Prolonged bleeding time (HP:0003010)2.78933335
49Mildly elevated creatine phosphokinase (HP:0008180)2.77708729
50Abnormal foot bone ossification (HP:0010675)2.76478758
51Congenital sensorineural hearing impairment (HP:0008527)2.75783130
52Dysostosis multiplex (HP:0000943)2.75371832
53Abnormality of vitamin B metabolism (HP:0004340)2.75163941
54Milia (HP:0001056)2.74754842
55Spontaneous hematomas (HP:0007420)2.74698550
56Hyperglycinuria (HP:0003108)2.74141780
57Abnormality of the distal phalanx of the thumb (HP:0009617)2.73822794
58Orchitis (HP:0100796)2.69726505
59Intrahepatic cholestasis (HP:0001406)2.68864707
60Broad face (HP:0000283)2.68785113
61Hyperaldosteronism (HP:0000859)2.67918735
62J-shaped sella turcica (HP:0002680)2.67668576
63Cerebral aneurysm (HP:0004944)2.66599697
64Progressive sensorineural hearing impairment (HP:0000408)2.66241435
65Meningitis (HP:0001287)2.64793597
66Cellulitis (HP:0100658)2.62628872
67Potter facies (HP:0002009)2.62164654
68Facial shape deformation (HP:0011334)2.62164654
69Abnormality of purine metabolism (HP:0004352)2.61712317
70Ureteral stenosis (HP:0000071)2.60347637
71Fragile nails (HP:0001808)2.59637998
72Glomerulonephritis (HP:0000099)2.58798949
73Recurrent cutaneous fungal infections (HP:0011370)2.58644677
74Chronic mucocutaneous candidiasis (HP:0002728)2.58644677
75Gastrointestinal infarctions (HP:0005244)2.56469075
76Panhypogammaglobulinemia (HP:0003139)2.54690906
77Abnormality of urine glucose concentration (HP:0011016)2.53966366
78Glycosuria (HP:0003076)2.53966366
79Alkalosis (HP:0001948)2.50899742
80Woolly hair (HP:0002224)2.49940111
81Agammaglobulinemia (HP:0004432)2.47613988
82Mucopolysacchariduria (HP:0008155)2.45770127
83Urinary glycosaminoglycan excretion (HP:0003541)2.45770127
84Abnormal biliary tract morphology (HP:0012440)2.45122868
85Abnormality of monocarboxylic acid metabolism (HP:0010996)2.44228594
86Thin bony cortex (HP:0002753)2.42601500
87Abnormality of polysaccharide metabolism (HP:0011012)2.42090890
88Abnormality of glycosaminoglycan metabolism (HP:0004371)2.42090890
89Abnormality of mucopolysaccharide metabolism (HP:0011020)2.42090890
90Vasculitis (HP:0002633)2.41864133
91Nephrolithiasis (HP:0000787)2.41812583
92Hemoptysis (HP:0002105)2.41425659
93Ureteral obstruction (HP:0006000)2.41217270
94Recurrent skin infections (HP:0001581)2.40990256
95Poikilocytosis (HP:0004447)2.39932173
96Amyloidosis (HP:0011034)2.39867263
97Abnormality of vitamin metabolism (HP:0100508)2.39565623
98Hypolipoproteinemia (HP:0010981)2.36886439
99Pili torti (HP:0003777)2.36100222
100Chronic obstructive pulmonary disease (HP:0006510)2.35520538
101Obstructive lung disease (HP:0006536)2.35520538
102Recurrent viral infections (HP:0004429)2.35398814
103Short phalanx of the thumb (HP:0009660)2.35048277
104Mediastinal lymphadenopathy (HP:0100721)2.34640716
105Abnormality of complement system (HP:0005339)2.34578609
106Symptomatic seizures (HP:0011145)2.33319709
107Abnormal hand bone ossification (HP:0010660)2.32427784
108Complement deficiency (HP:0004431)2.31549160
109Chest pain (HP:0100749)2.31370227
110Palpitations (HP:0001962)2.31279651
111Epistaxis (HP:0000421)2.30820649
112Alopecia of scalp (HP:0002293)2.29930058
113Progressive hearing impairment (HP:0001730)2.29886028
114Decreased circulating renin level (HP:0003351)2.27816134
115Retrobulbar optic neuritis (HP:0100654)2.24508476
116Optic neuritis (HP:0100653)2.24508476
117Encephalitis (HP:0002383)2.23485588
118Abnormal ossification of hand bones (HP:0005921)2.23342927
119Hyperparathyroidism (HP:0000843)2.23018616
120Symphalangism affecting the phalanges of the hand (HP:0009773)2.22557949
121Focal segmental glomerulosclerosis (HP:0000097)2.19414761
122Late onset (HP:0003584)2.18957768
123Flattened epiphyses (HP:0003071)2.18011336
124Hypokalemia (HP:0002900)2.17782200
125Pigmentary retinal degeneration (HP:0001146)2.17471103
126Autoimmune hemolytic anemia (HP:0001890)2.16951251
127Abnormality of aspartate family amino acid metabolism (HP:0010899)2.16600982
128Hyperphosphaturia (HP:0003109)2.15873398
129Emphysema (HP:0002097)2.14982952
130Interstitial pulmonary disease (HP:0006530)2.14933912
131Atrophic scars (HP:0001075)2.14472880
132Pulmonary infiltrates (HP:0002113)2.14077495
133Xanthomatosis (HP:0000991)2.13608934
134Increased cerebral lipofuscin (HP:0011813)2.13164410
135Biliary tract neoplasm (HP:0100574)2.12859679
136Syncope (HP:0001279)2.12246172
137Wide cranial sutures (HP:0010537)2.09828309
138Polycythemia (HP:0001901)2.09676721
139Abnormality of the gastric mucosa (HP:0004295)2.09155592
140Cervical subluxation (HP:0003308)2.07367813
141Osteomyelitis (HP:0002754)2.06854680
142Proximal tubulopathy (HP:0000114)2.06715656
143Hypertriglyceridemia (HP:0002155)2.04268026
144Abnormality of sulfur amino acid metabolism (HP:0004339)2.03529359
145Cone-rod dystrophy (HP:0000548)2.03364792
146Sensorimotor neuropathy (HP:0007141)2.02369534
147Neonatal short-limb short stature (HP:0008921)2.01980411
148Nephritis (HP:0000123)2.01926390
149Hoarse voice (HP:0001609)2.01751583
150Micronodular cirrhosis (HP:0001413)2.01748882
151Polygenic inheritance (HP:0010982)2.00818043
152Aneurysm (HP:0002617)1.95421527
153Papilledema (HP:0001085)1.95139803
154Abnormal urine phosphate concentration (HP:0012599)1.95030037
155Lymphangioma (HP:0100764)1.94755270
156Granulocytopenia (HP:0001913)1.93815535
157Delayed epiphyseal ossification (HP:0002663)1.93132177
158Breech presentation (HP:0001623)1.93028471
159Plantar hyperkeratosis (HP:0007556)1.92605152
160Increased neuronal autofluorescent lipopigment (HP:0002074)1.92450706
161Segmental peripheral demyelination/remyelination (HP:0003481)1.92335090
162Restrictive lung disease (HP:0002091)1.92316098
163Confusion (HP:0001289)1.91478029
164Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.91163384
165Vacuolated lymphocytes (HP:0001922)1.91012147
166Petechiae (HP:0000967)1.88781590
167Gastrointestinal stroma tumor (HP:0100723)1.88534529
168Onycholysis (HP:0001806)1.88259175
169Keratoconjunctivitis sicca (HP:0001097)1.86554765
170Myopathic facies (HP:0002058)1.86317421
171Hypophosphatemia (HP:0002148)1.85887296
172Protuberant abdomen (HP:0001538)1.85875280
173Premature loss of primary teeth (HP:0006323)1.85683960
174Cheilitis (HP:0100825)1.84768833
175Joint stiffness (HP:0001387)1.84447033
176Abnormality of the nasal mucosa (HP:0000433)1.83937250
177Metaphyseal cupping (HP:0003021)1.83712870
178Stomatitis (HP:0010280)1.82139911
179Hypochromic anemia (HP:0001931)1.81302382
180Distal lower limb amyotrophy (HP:0008944)1.80675530
181Loss of speech (HP:0002371)1.80378801
182Thoracic kyphosis (HP:0002942)1.80028047
183Visceral angiomatosis (HP:0100761)1.77833004
184Gingival bleeding (HP:0000225)1.76923286
185Asymmetric septal hypertrophy (HP:0001670)1.76232009
186Deformed sella turcica (HP:0002681)1.74230926

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.20372755
2MST1R5.19204322
3FRK4.77141267
4LMTK23.80684692
5PIK3CA3.59499974
6MAP2K23.24990455
7TRIB33.12695077
8MAP4K13.02089749
9PRKG22.96555768
10NME12.90233568
11GRK62.84066351
12PRPF4B2.81840083
13EPHB22.61003847
14RIPK12.53138317
15TNK22.50279683
16EPHA22.50044010
17MAP3K22.33338107
18TAOK32.33323334
19TYK22.28411718
20BLK2.14313811
21SIK11.90108633
22PTK61.90052445
23ZAP701.86846964
24TESK11.85219344
25MET1.84420959
26MAP2K31.80469647
27FES1.76353878
28TAOK11.73463009
29TBK11.71070620
30MYLK1.68809642
31AKT31.67591612
32MAP3K101.62067030
33MARK21.52643424
34ERN11.52162552
35WNK41.51483880
36KIT1.51468349
37BTK1.49599288
38MAP3K131.48206786
39DDR21.43257569
40MAP3K61.38212850
41KSR21.35530274
42PKN21.28091871
43JAK31.27011289
44PRKCI1.24224350
45MATK1.20515204
46CSF1R1.19155769
47PTK21.17683552
48NUAK11.15208239
49SYK1.14719191
50PRKD21.12327978
51DMPK1.11748550
52STK101.10129188
53IRAK41.10090667
54MAPK71.06787974
55MAP2K11.06029442
56HCK1.05051772
57JAK11.04811713
58PDPK11.02565721
59MAP3K81.00316583
60TTK1.00010596
61SIK20.98140321
62HIPK20.97373557
63SIK30.96714573
64ACVR1B0.94825125
65TESK20.91282425
66RIPK40.91042027
67EPHB10.89314990
68FGFR30.89274119
69TEC0.88040786
70RPS6KL10.87567399
71RPS6KC10.87567399
72MAP3K70.86057184
73MAPK120.84577017
74LCK0.84356619
75RPS6KA20.84355739
76LYN0.83614277
77MAP3K10.81493364
78TGFBR20.80653962
79OXSR10.78326511
80JAK20.78293567
81FER0.78161467
82PAK40.77775393
83ERBB20.76440436
84RPS6KA60.75416809
85CDK120.75191497
86CAMK2D0.73522070
87SMG10.72105035
88IKBKB0.71179155
89IKBKE0.69476090
90RET0.68013117
91PRKAA20.66524043
92EPHA30.65919655
93KDR0.65822460
94TXK0.65119920
95ICK0.64950439
96PDK10.64747081
97CAMKK10.62281278
98MAPK110.60514451
99MAP2K60.58902065
100DAPK20.57889290
101ARAF0.56863105
102TTN0.55124453
103MAP3K110.54871202
104WNK30.54568881
105CHUK0.53200154
106FYN0.53109817
107MARK30.51701086
108LIMK10.51648318
109PIM20.51490979
110IRAK10.51467102
111CSK0.50767580
112MAP3K90.47693663
113MAP3K30.47459399
114PDK20.47355916
115PDGFRB0.46601564
116MTOR0.45997094
117INSRR0.45965926
118PRKAA10.43735612
119BMX0.43218617
120CDC42BPA0.42903130
121PRKD10.42810258
122MAPK40.42697707
123NLK0.41639989
124MAPK30.41429426
125CDK60.41269573
126STK390.39937071
127PRKCA0.39229063
128LATS10.38662364
129BRAF0.37925771
130LRRK20.37017923
131CAMK2G0.34992634
132AURKB0.34009812
133DYRK1B0.32799631
134SRC0.32520856
135PAK10.30882499
136PAK30.30578900
137SCYL20.29693384
138CAMK2B0.29674065
139PDGFRA0.29273716
140MAP3K120.29230918
141PAK20.27716441
142ERBB40.26841692
143MELK0.26061498
144STK110.26053439
145MAPKAPK20.25907501
146MAPK150.24748521
147PRKACG0.23442165
148ROCK10.22034572
149CSNK1A10.21556253
150GRK10.20470799
151GSK3A0.20381101
152PBK0.20291419
153ITK0.19671504
154FGFR40.18137186
155CDK90.17895336
156AKT20.16392129
157PRKCD0.16128790
158FGR0.14131881
159MAP3K140.13494838
160EEF2K0.12941313

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049754.63512336
2Sulfur metabolism_Homo sapiens_hsa009204.62329424
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.50801471
4Mineral absorption_Homo sapiens_hsa049784.24341253
5Renin-angiotensin system_Homo sapiens_hsa046143.42221380
6Vitamin digestion and absorption_Homo sapiens_hsa049772.95798083
7Galactose metabolism_Homo sapiens_hsa000522.59214619
8Bile secretion_Homo sapiens_hsa049762.50293578
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.49360260
10Staphylococcus aureus infection_Homo sapiens_hsa051502.20870416
11Caffeine metabolism_Homo sapiens_hsa002322.18449419
12Carbohydrate digestion and absorption_Homo sapiens_hsa049732.15931659
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.14167295
14Starch and sucrose metabolism_Homo sapiens_hsa005002.13739482
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.09399119
16Protein digestion and absorption_Homo sapiens_hsa049742.07151826
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.01510327
18Leishmaniasis_Homo sapiens_hsa051402.01475174
19Fructose and mannose metabolism_Homo sapiens_hsa000511.96806243
20Histidine metabolism_Homo sapiens_hsa003401.95023285
21Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.77744342
22Osteoclast differentiation_Homo sapiens_hsa043801.77376805
23Asthma_Homo sapiens_hsa053101.72457378
24Allograft rejection_Homo sapiens_hsa053301.70234008
25Folate biosynthesis_Homo sapiens_hsa007901.69518361
26Graft-versus-host disease_Homo sapiens_hsa053321.64109537
27Autoimmune thyroid disease_Homo sapiens_hsa053201.57080232
28B cell receptor signaling pathway_Homo sapiens_hsa046621.56563090
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.54803100
30Tryptophan metabolism_Homo sapiens_hsa003801.48737755
31Acute myeloid leukemia_Homo sapiens_hsa052211.44787433
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.43149254
33Notch signaling pathway_Homo sapiens_hsa043301.39685206
34Pentose and glucuronate interconversions_Homo sapiens_hsa000401.38927990
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.37697537
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.35635527
37Glycerolipid metabolism_Homo sapiens_hsa005611.28943887
38PPAR signaling pathway_Homo sapiens_hsa033201.28272604
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.26481894
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.24832988
41Tuberculosis_Homo sapiens_hsa051521.23982572
42Glutathione metabolism_Homo sapiens_hsa004801.20306936
43Toxoplasmosis_Homo sapiens_hsa051451.18569859
44Fatty acid degradation_Homo sapiens_hsa000711.18253756
45Type I diabetes mellitus_Homo sapiens_hsa049401.13833562
46Hematopoietic cell lineage_Homo sapiens_hsa046401.08783733
47Butanoate metabolism_Homo sapiens_hsa006501.08235905
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07678990
49Influenza A_Homo sapiens_hsa051641.05610402
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05194005
51Sphingolipid metabolism_Homo sapiens_hsa006001.05166299
52Toll-like receptor signaling pathway_Homo sapiens_hsa046201.05056567
53Platelet activation_Homo sapiens_hsa046111.03384053
54GnRH signaling pathway_Homo sapiens_hsa049121.02479831
55Primary immunodeficiency_Homo sapiens_hsa053401.01145157
56TNF signaling pathway_Homo sapiens_hsa046681.00730600
57Phospholipase D signaling pathway_Homo sapiens_hsa040721.00584523
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.99364943
59Pancreatic secretion_Homo sapiens_hsa049720.98367311
60Chemokine signaling pathway_Homo sapiens_hsa040620.97418481
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95730933
62Antigen processing and presentation_Homo sapiens_hsa046120.94938089
63ABC transporters_Homo sapiens_hsa020100.94367600
64Tight junction_Homo sapiens_hsa045300.92791992
65T cell receptor signaling pathway_Homo sapiens_hsa046600.92153262
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91393770
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.89087224
68RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.88662080
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87389552
70VEGF signaling pathway_Homo sapiens_hsa043700.87305650
71Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87148401
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86367100
73Arginine and proline metabolism_Homo sapiens_hsa003300.83976762
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83692789
75Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82683007
76Pyruvate metabolism_Homo sapiens_hsa006200.82481287
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.82077910
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81315219
79Thyroid hormone synthesis_Homo sapiens_hsa049180.80283374
80Malaria_Homo sapiens_hsa051440.79559697
81Viral myocarditis_Homo sapiens_hsa054160.78916479
82Chronic myeloid leukemia_Homo sapiens_hsa052200.77714758
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75849768
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74954142
85Herpes simplex infection_Homo sapiens_hsa051680.73489163
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.72039233
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.71522179
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.71319213
89Non-small cell lung cancer_Homo sapiens_hsa052230.70859164
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70083739
91Arginine biosynthesis_Homo sapiens_hsa002200.69785868
92Dorso-ventral axis formation_Homo sapiens_hsa043200.69007849
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68192691
94beta-Alanine metabolism_Homo sapiens_hsa004100.67945457
95Lysosome_Homo sapiens_hsa041420.67469170
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.66813653
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66571353
98Amoebiasis_Homo sapiens_hsa051460.66154616
99Carbon metabolism_Homo sapiens_hsa012000.65889595
100Renin secretion_Homo sapiens_hsa049240.65786777
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64897190
102Hepatitis B_Homo sapiens_hsa051610.64800570
103Vascular smooth muscle contraction_Homo sapiens_hsa042700.63723407
104Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62870115
105Prolactin signaling pathway_Homo sapiens_hsa049170.62740493
106Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.62665487
107Estrogen signaling pathway_Homo sapiens_hsa049150.61428998
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61272765
109Linoleic acid metabolism_Homo sapiens_hsa005910.60669194
110Chemical carcinogenesis_Homo sapiens_hsa052040.60105498
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.59461847
112Pentose phosphate pathway_Homo sapiens_hsa000300.59214338
113Measles_Homo sapiens_hsa051620.57945618
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.56710925
115Drug metabolism - other enzymes_Homo sapiens_hsa009830.55998890
116Nitrogen metabolism_Homo sapiens_hsa009100.54955942
117mTOR signaling pathway_Homo sapiens_hsa041500.54527515
118Pancreatic cancer_Homo sapiens_hsa052120.53944641
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52211627
120Steroid biosynthesis_Homo sapiens_hsa001000.52091186
121Sulfur relay system_Homo sapiens_hsa041220.51782500
122Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48216076
123Gastric acid secretion_Homo sapiens_hsa049710.48174091
124Hepatitis C_Homo sapiens_hsa051600.47513928
125Complement and coagulation cascades_Homo sapiens_hsa046100.46523780
126Insulin signaling pathway_Homo sapiens_hsa049100.46413729
127Leukocyte transendothelial migration_Homo sapiens_hsa046700.45978583
128Bladder cancer_Homo sapiens_hsa052190.45853782
129Rheumatoid arthritis_Homo sapiens_hsa053230.45191080
130Salmonella infection_Homo sapiens_hsa051320.45047695
131Arachidonic acid metabolism_Homo sapiens_hsa005900.41088170
132Intestinal immune network for IgA production_Homo sapiens_hsa046720.40836052
133Adherens junction_Homo sapiens_hsa045200.40714193
134Salivary secretion_Homo sapiens_hsa049700.40177155
135Other glycan degradation_Homo sapiens_hsa005110.38209104
136Peroxisome_Homo sapiens_hsa041460.37923197
137Type II diabetes mellitus_Homo sapiens_hsa049300.37906468
138Phenylalanine metabolism_Homo sapiens_hsa003600.36159787
139Thyroid cancer_Homo sapiens_hsa052160.35863420
140Fatty acid metabolism_Homo sapiens_hsa012120.35818850
141Retinol metabolism_Homo sapiens_hsa008300.35242205
142Metabolic pathways_Homo sapiens_hsa011000.34176410
143Propanoate metabolism_Homo sapiens_hsa006400.30939178
144Selenocompound metabolism_Homo sapiens_hsa004500.30085168
145Vibrio cholerae infection_Homo sapiens_hsa051100.27600609
146Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.26593065
147Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.26439139
148Insulin secretion_Homo sapiens_hsa049110.24924072
149African trypanosomiasis_Homo sapiens_hsa051430.23386094
150Alzheimers disease_Homo sapiens_hsa050100.18623510
151Ether lipid metabolism_Homo sapiens_hsa005650.18466695
152Choline metabolism in cancer_Homo sapiens_hsa052310.17874494
153Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.16654014
154Oxidative phosphorylation_Homo sapiens_hsa001900.16253704
155Phosphatidylinositol signaling system_Homo sapiens_hsa040700.16060372
156Lysine degradation_Homo sapiens_hsa003100.14896968
157Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.14675452
158Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.14421348
159Inositol phosphate metabolism_Homo sapiens_hsa005620.12779403
160Biosynthesis of amino acids_Homo sapiens_hsa012300.08032982
161Pertussis_Homo sapiens_hsa051330.06967100
162Insulin resistance_Homo sapiens_hsa049310.06731393

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