MYO15A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an unconventional myosin. This protein differs from other myosins in that it has a long N-terminal extension preceding the conserved motor domain. Studies in mice suggest that this protein is necessary for actin organization in the hair cells of the cochlea. Mutations in this gene have been associated with profound, congenital, neurosensory, nonsyndromal deafness. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Read-through transcripts containing an upstream gene and this gene have been identified, but they are not thought to encode a fusion protein. Several alternatively spliced transcript variants have been described, but their full length sequences have not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.36722513
2DNA deamination (GO:0045006)5.30856817
3response to pheromone (GO:0019236)4.47618796
4protein polyglutamylation (GO:0018095)4.18984252
5water-soluble vitamin biosynthetic process (GO:0042364)4.02666436
6sperm motility (GO:0030317)3.71476332
7axoneme assembly (GO:0035082)3.69704271
8piRNA metabolic process (GO:0034587)3.61990821
9membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.61476125
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.56630118
11tryptophan catabolic process (GO:0006569)3.55205464
12indole-containing compound catabolic process (GO:0042436)3.55205464
13indolalkylamine catabolic process (GO:0046218)3.55205464
14indolalkylamine metabolic process (GO:0006586)3.53383275
15epithelial cilium movement (GO:0003351)3.44130398
16fucose catabolic process (GO:0019317)3.42256579
17L-fucose metabolic process (GO:0042354)3.42256579
18L-fucose catabolic process (GO:0042355)3.42256579
19negative regulation of telomere maintenance (GO:0032205)3.41501819
20kynurenine metabolic process (GO:0070189)3.37580079
21platelet dense granule organization (GO:0060155)3.37126805
22regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.36788606
23multicellular organism reproduction (GO:0032504)3.34646329
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.32264342
25mitochondrial respiratory chain complex I assembly (GO:0032981)3.32264342
26NADH dehydrogenase complex assembly (GO:0010257)3.32264342
27positive regulation of oligodendrocyte differentiation (GO:0048714)3.32027924
28cellular ketone body metabolic process (GO:0046950)3.31846684
29DNA methylation involved in gamete generation (GO:0043046)3.29790871
30detection of light stimulus involved in visual perception (GO:0050908)3.29584220
31detection of light stimulus involved in sensory perception (GO:0050962)3.29584220
32detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.24380546
33regulation of cilium movement (GO:0003352)3.21877130
34somite development (GO:0061053)3.21722060
35regulation of action potential (GO:0098900)3.17337711
36protein-cofactor linkage (GO:0018065)3.16517815
37cilium or flagellum-dependent cell motility (GO:0001539)3.15070571
38protein complex biogenesis (GO:0070271)3.10092911
39negative regulation of mast cell activation (GO:0033004)3.08568621
40rRNA catabolic process (GO:0016075)3.06877636
41tryptophan metabolic process (GO:0006568)3.05007896
42ketone body metabolic process (GO:1902224)2.99425587
43cilium movement (GO:0003341)2.99262244
44cAMP catabolic process (GO:0006198)2.96632006
45gamma-aminobutyric acid transport (GO:0015812)2.85080933
46indole-containing compound metabolic process (GO:0042430)2.83070267
47negative regulation of synaptic transmission, GABAergic (GO:0032229)2.82778239
48mitochondrial respiratory chain complex assembly (GO:0033108)2.82607662
49regulation of mesoderm development (GO:2000380)2.79337542
50neuronal action potential (GO:0019228)2.79037335
51primary amino compound metabolic process (GO:1901160)2.78923810
52regulation of rhodopsin mediated signaling pathway (GO:0022400)2.78304554
53acrosome reaction (GO:0007340)2.77000839
54synaptic transmission, cholinergic (GO:0007271)2.76028728
55preassembly of GPI anchor in ER membrane (GO:0016254)2.74434634
56sulfation (GO:0051923)2.73118821
57rhodopsin mediated signaling pathway (GO:0016056)2.70901517
58mannosylation (GO:0097502)2.69230043
59adaptation of signaling pathway (GO:0023058)2.68864533
60membrane depolarization during action potential (GO:0086010)2.66667592
61spinal cord motor neuron differentiation (GO:0021522)2.62699229
62cyclic nucleotide catabolic process (GO:0009214)2.61988236
63axonemal dynein complex assembly (GO:0070286)2.60820391
64retinal cone cell development (GO:0046549)2.60291403
65cell proliferation in forebrain (GO:0021846)2.60073048
66GPI anchor metabolic process (GO:0006505)2.57423241
67positive regulation of fatty acid transport (GO:2000193)2.54833860
68photoreceptor cell development (GO:0042461)2.53184293
69regulation of neurotransmitter uptake (GO:0051580)2.50041057
70response to lipoprotein particle (GO:0055094)2.49511694
71photoreceptor cell maintenance (GO:0045494)2.48665543
72centriole replication (GO:0007099)2.48503902
73endoderm formation (GO:0001706)2.47501984
74male meiosis I (GO:0007141)2.47472471
75positive regulation of defense response to virus by host (GO:0002230)2.47119876
76cellular response to ATP (GO:0071318)2.45766527
77RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.43094497
78regulation of posttranscriptional gene silencing (GO:0060147)2.42618573
79regulation of gene silencing by miRNA (GO:0060964)2.42618573
80regulation of gene silencing by RNA (GO:0060966)2.42618573
81calcium ion-dependent exocytosis (GO:0017156)2.42533587
82behavioral response to ethanol (GO:0048149)2.42276252
83G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.42168047
84NAD biosynthetic process (GO:0009435)2.42105522
85transepithelial transport (GO:0070633)2.41325780
86positive regulation of triglyceride biosynthetic process (GO:0010867)2.40794414
87regulation of hippo signaling (GO:0035330)2.40088752
88transmission of nerve impulse (GO:0019226)2.38829882
89regulation of microtubule-based movement (GO:0060632)2.37688213
90male meiosis (GO:0007140)2.37477999
91amine catabolic process (GO:0009310)2.37038826
92cellular biogenic amine catabolic process (GO:0042402)2.37038826
93double-strand break repair via homologous recombination (GO:0000724)2.35594347
94recombinational repair (GO:0000725)2.35296276
95nephron tubule morphogenesis (GO:0072078)2.35070267
96nephron epithelium morphogenesis (GO:0072088)2.35070267
97proline transport (GO:0015824)2.34963241
98aromatic amino acid family catabolic process (GO:0009074)2.34445650
99nonmotile primary cilium assembly (GO:0035058)2.34351299
100protein import into peroxisome matrix (GO:0016558)2.33002124

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.68681550
2ZNF274_21170338_ChIP-Seq_K562_Hela3.66491652
3VDR_22108803_ChIP-Seq_LS180_Human3.28361019
4GBX2_23144817_ChIP-Seq_PC3_Human2.88023103
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.29387332
6CTBP1_25329375_ChIP-Seq_LNCAP_Human2.23861393
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23254597
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.17462254
9IGF1R_20145208_ChIP-Seq_DFB_Human2.15325483
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.08016266
11FUS_26573619_Chip-Seq_HEK293_Human1.93418747
12EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.86020357
13P300_19829295_ChIP-Seq_ESCs_Human1.83288437
14FLI1_27457419_Chip-Seq_LIVER_Mouse1.82239448
15POU3F2_20337985_ChIP-ChIP_501MEL_Human1.81142263
16TAF15_26573619_Chip-Seq_HEK293_Human1.75099495
17BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73316202
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.73069992
19ER_23166858_ChIP-Seq_MCF-7_Human1.69883540
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68184463
21UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.63925736
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.63618872
23CBX2_27304074_Chip-Seq_ESCs_Mouse1.63386451
24EWS_26573619_Chip-Seq_HEK293_Human1.60373841
25CBP_20019798_ChIP-Seq_JUKART_Human1.58067508
26IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.58067508
27MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.55740663
28REST_21632747_ChIP-Seq_MESCs_Mouse1.50478829
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47624994
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46408462
31AR_25329375_ChIP-Seq_VCAP_Human1.44042786
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43608618
33NOTCH1_21737748_ChIP-Seq_TLL_Human1.41272128
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.39908517
35RNF2_27304074_Chip-Seq_NSC_Mouse1.38040715
36* STAT3_23295773_ChIP-Seq_U87_Human1.37994133
37SMAD4_21799915_ChIP-Seq_A2780_Human1.37615728
38TP53_22573176_ChIP-Seq_HFKS_Human1.36618025
39JARID2_20064375_ChIP-Seq_MESCs_Mouse1.34484559
40FOXA1_27270436_Chip-Seq_PROSTATE_Human1.34263104
41FOXA1_25329375_ChIP-Seq_VCAP_Human1.34263104
42GATA3_21878914_ChIP-Seq_MCF-7_Human1.33422393
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33200707
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33153925
45IRF1_19129219_ChIP-ChIP_H3396_Human1.32636056
46EZH2_27304074_Chip-Seq_ESCs_Mouse1.32548739
47SOX2_19829295_ChIP-Seq_ESCs_Human1.31492045
48NANOG_19829295_ChIP-Seq_ESCs_Human1.31492045
49TCF4_23295773_ChIP-Seq_U87_Human1.30668863
50EED_16625203_ChIP-ChIP_MESCs_Mouse1.30251995
51BCAT_22108803_ChIP-Seq_LS180_Human1.29229011
52KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26978570
53NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26805578
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26355275
55AUTS2_25519132_ChIP-Seq_293T-REX_Human1.26132902
56MYC_18940864_ChIP-ChIP_HL60_Human1.24878860
57SMAD4_21741376_ChIP-Seq_EPCs_Human1.24176434
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23740327
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23740327
60ETV2_25802403_ChIP-Seq_MESCs_Mouse1.22931225
61NCOR_22424771_ChIP-Seq_293T_Human1.22752615
62SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.22061870
63EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21961296
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21365116
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21224826
66TCF4_22108803_ChIP-Seq_LS180_Human1.20414780
67EZH2_27294783_Chip-Seq_ESCs_Mouse1.19339753
68SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19177162
69RUNX2_22187159_ChIP-Seq_PCA_Human1.18942050
70PRDM14_20953172_ChIP-Seq_ESCs_Human1.18850180
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18537135
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17981609
73FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15914627
74JARID2_20075857_ChIP-Seq_MESCs_Mouse1.15223038
75NFE2_27457419_Chip-Seq_LIVER_Mouse1.14186394
76PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14042651
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13329612
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.12811940
79DROSHA_22980978_ChIP-Seq_HELA_Human1.12012411
80MYC_19829295_ChIP-Seq_ESCs_Human1.11023769
81SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.10921820
82* SMAD3_21741376_ChIP-Seq_EPCs_Human1.10716695
83AR_20517297_ChIP-Seq_VCAP_Human1.09459160
84TAF2_19829295_ChIP-Seq_ESCs_Human1.08180582
85NANOG_20526341_ChIP-Seq_ESCs_Human1.07708780
86SUZ12_27294783_Chip-Seq_ESCs_Mouse1.07488558
87E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.07334746
88REST_18959480_ChIP-ChIP_MESCs_Mouse1.06699232
89PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06284306
90HOXB7_26014856_ChIP-Seq_BT474_Human1.06191935
91FLI1_21867929_ChIP-Seq_TH2_Mouse1.06180136
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05161021
93CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04390097
94RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03855766
95ERA_21632823_ChIP-Seq_H3396_Human1.03510917
96CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03214254
97SALL1_21062744_ChIP-ChIP_HESCs_Human1.01031644
98TDRD3_21172665_ChIP-Seq_MCF-7_Human0.99964655
99EZH2_27294783_Chip-Seq_NPCs_Mouse0.99765308
100EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.98607334

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005646_abnormal_pituitary_gland2.97142601
2MP0003283_abnormal_digestive_organ2.81872594
3MP0002102_abnormal_ear_morphology2.75673790
4MP0008877_abnormal_DNA_methylation2.63230924
5MP0006292_abnormal_olfactory_placode2.54030192
6MP0005551_abnormal_eye_electrophysiolog2.42763087
7MP0001968_abnormal_touch/_nociception2.42535630
8MP0002876_abnormal_thyroid_physiology2.29858729
9MP0005410_abnormal_fertilization2.25294850
10MP0004885_abnormal_endolymph2.21249355
11MP0002837_dystrophic_cardiac_calcinosis2.21058237
12MP0001485_abnormal_pinna_reflex2.20148264
13MP0003195_calcinosis2.19607753
14MP0003646_muscle_fatigue2.11464358
15MP0002736_abnormal_nociception_after1.94847612
16MP0005645_abnormal_hypothalamus_physiol1.91648831
17MP0002138_abnormal_hepatobiliary_system1.90212301
18MP0009745_abnormal_behavioral_response1.88942367
19MP0003011_delayed_dark_adaptation1.87586770
20MP0003136_yellow_coat_color1.85954723
21MP0000631_abnormal_neuroendocrine_gland1.81248566
22MP0003878_abnormal_ear_physiology1.78523743
23MP0005377_hearing/vestibular/ear_phenot1.78523743
24MP0002272_abnormal_nervous_system1.77657697
25MP0004142_abnormal_muscle_tone1.74398173
26MP0006072_abnormal_retinal_apoptosis1.73112265
27MP0009046_muscle_twitch1.70768109
28MP0005253_abnormal_eye_physiology1.64113370
29MP0001501_abnormal_sleep_pattern1.62951887
30MP0005670_abnormal_white_adipose1.59491606
31MP0008875_abnormal_xenobiotic_pharmacok1.58093366
32MP0008872_abnormal_physiological_respon1.57660122
33MP0001986_abnormal_taste_sensitivity1.54342970
34MP0003880_abnormal_central_pattern1.53452993
35MP0006276_abnormal_autonomic_nervous1.51782227
36MP0001486_abnormal_startle_reflex1.46281100
37MP0003787_abnormal_imprinting1.44767840
38MP0002160_abnormal_reproductive_system1.42537339
39MP0002638_abnormal_pupillary_reflex1.40396228
40MP0000049_abnormal_middle_ear1.39428831
41MP0005389_reproductive_system_phenotype1.37190898
42MP0005174_abnormal_tail_pigmentation1.35677041
43MP0000569_abnormal_digit_pigmentation1.34195009
44MP0004043_abnormal_pH_regulation1.30903814
45MP0002735_abnormal_chemical_nociception1.28403481
46MP0000372_irregular_coat_pigmentation1.27996073
47MP0002064_seizures1.24465035
48MP0004133_heterotaxia1.24437097
49MP0003119_abnormal_digestive_system1.24429879
50MP0002572_abnormal_emotion/affect_behav1.23976843
51MP0002653_abnormal_ependyma_morphology1.23591059
52MP0004147_increased_porphyrin_level1.20063117
53MP0003698_abnormal_male_reproductive1.17538291
54MP0003718_maternal_effect1.15786345
55MP0002733_abnormal_thermal_nociception1.15029565
56MP0000026_abnormal_inner_ear1.14122205
57MP0003635_abnormal_synaptic_transmissio1.12635924
58MP0002557_abnormal_social/conspecific_i1.11575343
59MP0001905_abnormal_dopamine_level1.11016351
60MP0002234_abnormal_pharynx_morphology1.10772045
61MP0001970_abnormal_pain_threshold1.10079895
62MP0001984_abnormal_olfaction1.09264231
63MP0001963_abnormal_hearing_physiology1.08874387
64MP0002938_white_spotting1.08550780
65MP0003879_abnormal_hair_cell1.06776566
66MP0004742_abnormal_vestibular_system1.06715962
67MP0002067_abnormal_sensory_capabilities1.05500798
68MP0001919_abnormal_reproductive_system1.05489288
69MP0002277_abnormal_respiratory_mucosa1.04761552
70MP0005084_abnormal_gallbladder_morpholo1.04046149
71MP0000427_abnormal_hair_cycle1.03336310
72MP0002063_abnormal_learning/memory/cond1.02311890
73MP0003938_abnormal_ear_development0.99947117
74MP0005423_abnormal_somatic_nervous0.99833967
75MP0002751_abnormal_autonomic_nervous0.99011074
76MP0001929_abnormal_gametogenesis0.98939272
77MP0003724_increased_susceptibility_to0.96253494
78MP0002229_neurodegeneration0.95468150
79MP0005195_abnormal_posterior_eye0.93443615
80MP0000516_abnormal_urinary_system0.92879901
81MP0005367_renal/urinary_system_phenotyp0.92879901
82MP0000013_abnormal_adipose_tissue0.91525229
83MP0002928_abnormal_bile_duct0.88533380
84MP0000230_abnormal_systemic_arterial0.86088488
85MP0001764_abnormal_homeostasis0.85566712
86MP0002282_abnormal_trachea_morphology0.83450601
87MP0008995_early_reproductive_senescence0.83194105
88MP0000383_abnormal_hair_follicle0.83127394
89MP0005379_endocrine/exocrine_gland_phen0.83043618
90MP0002734_abnormal_mechanical_nocicepti0.82474230
91MP0002752_abnormal_somatic_nervous0.82298771
92MP0004145_abnormal_muscle_electrophysio0.82191147
93MP0001440_abnormal_grooming_behavior0.81176887
94MP0005332_abnormal_amino_acid0.80313759
95MP0005075_abnormal_melanosome_morpholog0.79284999
96MP0002210_abnormal_sex_determination0.79140096
97MP0002095_abnormal_skin_pigmentation0.78572504
98MP0004130_abnormal_muscle_cell0.78466933
99MP0010386_abnormal_urinary_bladder0.75436397
100MP0003252_abnormal_bile_duct0.74957268

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.25604576
2Congenital stationary night blindness (HP:0007642)3.92478990
3Pancreatic fibrosis (HP:0100732)3.78115400
4True hermaphroditism (HP:0010459)3.73103415
5Nephronophthisis (HP:0000090)3.71179405
6Abnormality of midbrain morphology (HP:0002418)3.60883953
7Molar tooth sign on MRI (HP:0002419)3.60883953
8Attenuation of retinal blood vessels (HP:0007843)3.32264248
9Abnormality of the renal medulla (HP:0100957)3.19015838
10Type II lissencephaly (HP:0007260)3.14004084
11Pendular nystagmus (HP:0012043)3.10647657
12Abolished electroretinogram (ERG) (HP:0000550)3.08054779
13Chronic hepatic failure (HP:0100626)3.06552644
14Abnormality of the renal cortex (HP:0011035)3.02186582
15Polydipsia (HP:0001959)2.77297373
16Abnormal drinking behavior (HP:0030082)2.77297373
17Abnormal rod and cone electroretinograms (HP:0008323)2.71173776
18Dynein arm defect of respiratory motile cilia (HP:0012255)2.68756010
19Absent/shortened dynein arms (HP:0200106)2.68756010
20Abnormal respiratory motile cilium morphology (HP:0005938)2.64446566
21Abnormal respiratory epithelium morphology (HP:0012253)2.64446566
22Clumsiness (HP:0002312)2.64381718
23Cystic liver disease (HP:0006706)2.63037365
24Keratoconus (HP:0000563)2.60738753
25Increased corneal curvature (HP:0100692)2.60738753
26Decreased central vision (HP:0007663)2.58536109
27Medial flaring of the eyebrow (HP:0010747)2.51819425
28Congenital sensorineural hearing impairment (HP:0008527)2.51574576
29Methylmalonic acidemia (HP:0002912)2.51145644
30Sclerocornea (HP:0000647)2.50813000
31Severe visual impairment (HP:0001141)2.49098600
32Decreased electroretinogram (ERG) amplitude (HP:0000654)2.44711660
33Abnormal ciliary motility (HP:0012262)2.42666721
34Bony spicule pigmentary retinopathy (HP:0007737)2.41468427
35Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.32648751
36Abnormality of alanine metabolism (HP:0010916)2.32648751
37Hyperalaninemia (HP:0003348)2.32648751
38Tubular atrophy (HP:0000092)2.29581688
39Methylmalonic aciduria (HP:0012120)2.28774451
40Progressive cerebellar ataxia (HP:0002073)2.27415006
41Genetic anticipation (HP:0003743)2.24344130
42Congenital, generalized hypertrichosis (HP:0004540)2.24076517
43Aplasia/Hypoplasia of the tibia (HP:0005772)2.20546107
44Decreased circulating renin level (HP:0003351)2.18154962
45Chorioretinal atrophy (HP:0000533)2.15878851
46Acute necrotizing encephalopathy (HP:0006965)2.15191484
47Polyuria (HP:0000103)2.14853282
48Renal cortical cysts (HP:0000803)2.14665545
49Abnormal respiratory motile cilium physiology (HP:0012261)2.12890601
50Gaze-evoked nystagmus (HP:0000640)2.09378842
51Cerebellar dysplasia (HP:0007033)2.08830945
52Absent rod-and cone-mediated responses on ERG (HP:0007688)2.07162375
53Mitochondrial inheritance (HP:0001427)2.05906269
54Stomach cancer (HP:0012126)2.04921826
55Congenital hepatic fibrosis (HP:0002612)2.02857559
56Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.02594809
57Furrowed tongue (HP:0000221)2.01958081
58Increased CSF lactate (HP:0002490)1.98620259
59Anencephaly (HP:0002323)1.98421900
60Severe muscular hypotonia (HP:0006829)1.98252962
61Hyperglycinemia (HP:0002154)1.98055288
62Inability to walk (HP:0002540)1.97522233
63Male pseudohermaphroditism (HP:0000037)1.96449068
64Aplasia/Hypoplasia of the tongue (HP:0010295)1.95784014
65Thyroid-stimulating hormone excess (HP:0002925)1.92827410
66Abnormal biliary tract physiology (HP:0012439)1.92565199
67Bile duct proliferation (HP:0001408)1.92565199
68Abnormality of macular pigmentation (HP:0008002)1.91302285
69Acute encephalopathy (HP:0006846)1.90850006
70Aplasia/Hypoplasia of the spleen (HP:0010451)1.90849060
71Gait imbalance (HP:0002141)1.90612324
72Hypoplasia of the pons (HP:0012110)1.90090925
73Short tibia (HP:0005736)1.87802852
74Optic nerve hypoplasia (HP:0000609)1.87697904
75Abnormality of the renal collecting system (HP:0004742)1.86957160
76Progressive macrocephaly (HP:0004481)1.85957316
77Asplenia (HP:0001746)1.85619160
78Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.84281099
79Short 1st metacarpal (HP:0010034)1.84281099
80Abnormality of the nasal septum (HP:0000419)1.84204239
81Small hand (HP:0200055)1.83495230
82Hyperventilation (HP:0002883)1.82750275
833-Methylglutaconic aciduria (HP:0003535)1.82508927
84Abnormality of the pons (HP:0007361)1.82196297
85Absent thumb (HP:0009777)1.81813947
86Retinal dysplasia (HP:0007973)1.81204611
87Optic disc pallor (HP:0000543)1.79726133
88Congenital primary aphakia (HP:0007707)1.79495089
89Abnormal urine output (HP:0012590)1.78425904
90Stenosis of the external auditory canal (HP:0000402)1.74012479
91Abnormal mitochondria in muscle tissue (HP:0008316)1.73461262
92Febrile seizures (HP:0002373)1.72333261
93Disproportionate short-trunk short stature (HP:0003521)1.72011828
94Abnormality of DNA repair (HP:0003254)1.71607697
95Postaxial foot polydactyly (HP:0001830)1.70627443
96Megalencephaly (HP:0001355)1.69724158
97Ketosis (HP:0001946)1.69711002
98Aplasia/Hypoplasia of the patella (HP:0006498)1.68991055
99Lissencephaly (HP:0001339)1.66973041
100IgG deficiency (HP:0004315)1.65446224

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.98682377
2TLK14.06096739
3MAP4K23.30903792
4ADRBK23.07498855
5GRK12.94307534
6BMPR1B2.80074677
7TAOK32.76015889
8PINK12.50074146
9ZAK2.30198775
10WNK32.14214768
11INSRR2.10896517
12NUAK12.07248856
13TXK1.95821237
14WNK41.93852155
15MAPK131.83875794
16ACVR1B1.81080121
17PLK41.80240794
18OXSR11.50914383
19DAPK21.43995279
20PLK21.41100468
21BCKDK1.31410372
22STK391.26980416
23MAP3K41.26055693
24PHKG11.23999793
25PHKG21.23999793
26CASK1.21563923
27MUSK1.18861925
28PNCK1.15996322
29NTRK31.08073369
30DYRK21.03337652
31ADRBK10.99617952
32STK38L0.98583436
33MARK10.97413324
34PRKCG0.94890515
35TNIK0.93244548
36EPHA40.88210409
37KIT0.86688979
38MAPK150.85837695
39PRKCE0.82596510
40IKBKB0.81663863
41TIE10.81386011
42PAK30.78511836
43CSNK1G20.78323673
44PTK2B0.75319270
45MAP2K70.75207609
46NTRK20.74478613
47CSNK1G30.73973830
48FLT30.73032642
49GRK70.69913890
50VRK10.69865332
51VRK20.69422888
52CAMKK20.67715724
53CSNK1G10.67645898
54TRIM280.66412250
55MAPKAPK50.64862759
56STK160.64014619
57TEC0.63461991
58TGFBR10.62355073
59MKNK20.61664499
60ITK0.61130254
61MAP2K20.61086290
62NME10.57342840
63PRKCQ0.55405065
64PRKACA0.53904498
65CDK190.53336016
66PKN10.53217878
67CAMK10.52218415
68PIK3CG0.51542561
69CSNK1A1L0.50745887
70CSNK1A10.50487855
71MAP3K90.50438720
72RPS6KA50.49029732
73MAP2K10.48510744
74MAPKAPK30.48486752
75TAF10.48426751
76GRK50.48388597
77MAP2K60.46902070
78CAMK2A0.45965747
79NEK20.45756706
80TNK20.44580957
81PIK3CA0.44222607
82SYK0.41615056
83GRK60.40963104
84FGFR20.39947322
85PRKCI0.37563307
86PRKCA0.37496736
87EIF2AK30.37425563
88EPHA30.36082071
89BUB10.34940471
90PASK0.34482301
91RPS6KA60.34450905
92CSNK1D0.34317009
93IGF1R0.32477936
94STK110.32317849
95PRKCZ0.32163333
96SIK20.31509012
97PRKG10.31229190
98SGK2230.30559662
99SGK4940.30559662
100WNK10.29219832

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.92069771
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.63623717
3Nicotine addiction_Homo sapiens_hsa050332.45776214
4Linoleic acid metabolism_Homo sapiens_hsa005912.44335382
5Selenocompound metabolism_Homo sapiens_hsa004502.35579117
6Nitrogen metabolism_Homo sapiens_hsa009102.25377318
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.22558341
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.21148806
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.18641942
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.15143783
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.13848438
12Butanoate metabolism_Homo sapiens_hsa006502.04752357
13Oxidative phosphorylation_Homo sapiens_hsa001902.03594040
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.92929512
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.80448486
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.77820418
17Tryptophan metabolism_Homo sapiens_hsa003801.70328491
18RNA polymerase_Homo sapiens_hsa030201.70314051
19Morphine addiction_Homo sapiens_hsa050321.69265037
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.64840351
21Homologous recombination_Homo sapiens_hsa034401.61726920
22Ether lipid metabolism_Homo sapiens_hsa005651.56493327
23Parkinsons disease_Homo sapiens_hsa050121.55608862
24Olfactory transduction_Homo sapiens_hsa047401.54550499
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.53772103
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.49644697
27Taste transduction_Homo sapiens_hsa047421.42775192
28Fanconi anemia pathway_Homo sapiens_hsa034601.40814847
29Caffeine metabolism_Homo sapiens_hsa002321.36598779
30RNA degradation_Homo sapiens_hsa030181.25904988
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.24995964
32Chemical carcinogenesis_Homo sapiens_hsa052041.24014241
33Retinol metabolism_Homo sapiens_hsa008301.23122960
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.22788454
35Cardiac muscle contraction_Homo sapiens_hsa042601.19829860
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.17386039
37Protein export_Homo sapiens_hsa030601.13814847
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12044945
39Peroxisome_Homo sapiens_hsa041461.11950508
40Basal transcription factors_Homo sapiens_hsa030221.11140194
41Huntingtons disease_Homo sapiens_hsa050161.10845446
42Sulfur metabolism_Homo sapiens_hsa009201.09955321
43Glycerolipid metabolism_Homo sapiens_hsa005611.09157317
44Circadian entrainment_Homo sapiens_hsa047131.09017035
45GABAergic synapse_Homo sapiens_hsa047271.08964489
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.06779142
47Primary immunodeficiency_Homo sapiens_hsa053401.05222215
48Serotonergic synapse_Homo sapiens_hsa047261.03834144
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02157549
50Alzheimers disease_Homo sapiens_hsa050101.01473433
51ABC transporters_Homo sapiens_hsa020101.01249464
52Asthma_Homo sapiens_hsa053101.00711929
53Glutamatergic synapse_Homo sapiens_hsa047241.00073998
54Arachidonic acid metabolism_Homo sapiens_hsa005900.99708815
55Regulation of autophagy_Homo sapiens_hsa041400.99098589
56Insulin secretion_Homo sapiens_hsa049110.97404898
57Type I diabetes mellitus_Homo sapiens_hsa049400.92328165
58Propanoate metabolism_Homo sapiens_hsa006400.90931550
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90550379
60Fat digestion and absorption_Homo sapiens_hsa049750.87443856
61Collecting duct acid secretion_Homo sapiens_hsa049660.86334450
62Sulfur relay system_Homo sapiens_hsa041220.83331685
63One carbon pool by folate_Homo sapiens_hsa006700.82340022
64Purine metabolism_Homo sapiens_hsa002300.81984638
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81841429
66Salivary secretion_Homo sapiens_hsa049700.80678629
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79861097
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79137046
69Allograft rejection_Homo sapiens_hsa053300.78200350
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76765431
71Graft-versus-host disease_Homo sapiens_hsa053320.76684963
72Ovarian steroidogenesis_Homo sapiens_hsa049130.75060513
73Calcium signaling pathway_Homo sapiens_hsa040200.72670734
74Autoimmune thyroid disease_Homo sapiens_hsa053200.72612846
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70993016
76Fatty acid biosynthesis_Homo sapiens_hsa000610.70368836
77Metabolic pathways_Homo sapiens_hsa011000.62326182
78beta-Alanine metabolism_Homo sapiens_hsa004100.60275661
79Dorso-ventral axis formation_Homo sapiens_hsa043200.51999913
80Cholinergic synapse_Homo sapiens_hsa047250.50147893
81Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.49783748
82cAMP signaling pathway_Homo sapiens_hsa040240.48342269
83Dopaminergic synapse_Homo sapiens_hsa047280.48230947
84Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47806283
85Vitamin digestion and absorption_Homo sapiens_hsa049770.47667237
86Mineral absorption_Homo sapiens_hsa049780.46988368
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.46931783
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46899084
89Pyrimidine metabolism_Homo sapiens_hsa002400.46423812
90Fatty acid degradation_Homo sapiens_hsa000710.45425377
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43989448
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.43541858
93Histidine metabolism_Homo sapiens_hsa003400.41396332
94Amphetamine addiction_Homo sapiens_hsa050310.39827100
95Gastric acid secretion_Homo sapiens_hsa049710.38974159
96Renin secretion_Homo sapiens_hsa049240.37960686
97Ribosome_Homo sapiens_hsa030100.37949743
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37427769
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36588044
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.33552345

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