MYLK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1collagen fibril organization (GO:0030199)4.57549120
2endocardial cushion development (GO:0003197)4.33125008
3sequestering of extracellular ligand from receptor (GO:0035581)4.22955155
4cell migration involved in heart development (GO:0060973)4.21122301
5sulfur amino acid catabolic process (GO:0000098)4.10293881
6extracellular fibril organization (GO:0043206)4.01933899
7endodermal cell differentiation (GO:0035987)3.99228796
8complement activation, alternative pathway (GO:0006957)3.98716597
9alpha-linolenic acid metabolic process (GO:0036109)3.97752448
10glomerular basement membrane development (GO:0032836)3.96355751
11cGMP-mediated signaling (GO:0019934)3.89761125
12glomerular visceral epithelial cell development (GO:0072015)3.87013152
13bone trabecula formation (GO:0060346)3.79511007
14skin morphogenesis (GO:0043589)3.77659332
15mesenchymal-epithelial cell signaling (GO:0060638)3.75590308
16chondrocyte proliferation (GO:0035988)3.75460558
17kidney mesenchyme development (GO:0072074)3.74441124
18type B pancreatic cell proliferation (GO:0044342)3.68343677
19regulation of protein activation cascade (GO:2000257)3.67208351
20regulation of complement activation (GO:0030449)3.66449965
21metanephric mesenchyme development (GO:0072075)3.61468342
22regulation of integrin-mediated signaling pathway (GO:2001044)3.57879756
23lung vasculature development (GO:0060426)3.56360030
24negative regulation of smooth muscle cell migration (GO:0014912)3.55122135
25fibril organization (GO:0097435)3.50703939
26cell-substrate junction assembly (GO:0007044)3.47527730
27cellular response to vitamin (GO:0071295)3.42688377
28smooth muscle tissue development (GO:0048745)3.40937885
29fibroblast migration (GO:0010761)3.39531561
30erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.39173603
31L-phenylalanine catabolic process (GO:0006559)3.39173603
32glomerular epithelial cell development (GO:0072310)3.37883243
33cell adhesion mediated by integrin (GO:0033627)3.36793287
34pericardium development (GO:0060039)3.32277643
35basement membrane organization (GO:0071711)3.32161936
36valine metabolic process (GO:0006573)3.29497356
37virion attachment to host cell (GO:0019062)3.29369602
38adhesion of symbiont to host cell (GO:0044650)3.29369602
39protein carboxylation (GO:0018214)3.26430382
40peptidyl-glutamic acid carboxylation (GO:0017187)3.26430382
41collagen metabolic process (GO:0032963)3.25432830
42glomerulus development (GO:0032835)3.23386144
43L-phenylalanine metabolic process (GO:0006558)3.22967748
44erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.22967748
45mesodermal cell differentiation (GO:0048333)3.22270708
46renal filtration (GO:0097205)3.15632977
47positive regulation of endothelial cell apoptotic process (GO:2000353)3.15249930
48drug transmembrane transport (GO:0006855)3.14988058
49fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.14342466
50triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.13299186
51cysteine metabolic process (GO:0006534)3.12500449
52actin filament depolymerization (GO:0030042)3.11948653
53positive regulation of fatty acid beta-oxidation (GO:0032000)3.09602743
54negative regulation of fatty acid transport (GO:2000192)3.08912808
55collagen catabolic process (GO:0030574)3.08774684
56transcytosis (GO:0045056)3.05534455
57multicellular organismal macromolecule metabolic process (GO:0044259)3.04611105
58substrate adhesion-dependent cell spreading (GO:0034446)3.04439327
59homocysteine metabolic process (GO:0050667)3.03510340
60relaxation of smooth muscle (GO:0044557)2.99257872
61extracellular matrix assembly (GO:0085029)2.99046556
62vascular endothelial growth factor signaling pathway (GO:0038084)2.98055053
63midgut development (GO:0007494)2.97867231
64glomerular filtration (GO:0003094)2.97553263
65apoptotic cell clearance (GO:0043277)2.93702851
66positive regulation of fibroblast migration (GO:0010763)2.92915186
67cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.92321451
68cell migration involved in sprouting angiogenesis (GO:0002042)2.90875671
69negative regulation of fibrinolysis (GO:0051918)2.90836225
70protein heterotrimerization (GO:0070208)2.90388499
71adherens junction assembly (GO:0034333)2.90189976
72platelet aggregation (GO:0070527)2.89894984
73multicellular organismal metabolic process (GO:0044236)2.89549805
74protein localization to cell surface (GO:0034394)2.89487677
75regulation of cholesterol homeostasis (GO:2000188)2.89097607
76low-density lipoprotein particle clearance (GO:0034383)2.88026696
77lysine metabolic process (GO:0006553)2.87443594
78lysine catabolic process (GO:0006554)2.87443594
79aromatic amino acid family catabolic process (GO:0009074)2.87195395
80ethanol oxidation (GO:0006069)2.86535922
81regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.85266802
82extracellular matrix disassembly (GO:0022617)2.85192488
83multicellular organismal catabolic process (GO:0044243)2.85043264
84bile acid and bile salt transport (GO:0015721)2.84295752
85regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.84038766
86cellular response to vitamin D (GO:0071305)2.83607307
87positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.83185821
88cell-substrate adherens junction assembly (GO:0007045)2.83119079
89focal adhesion assembly (GO:0048041)2.83119079
90barbed-end actin filament capping (GO:0051016)2.82011533
91regulation of triglyceride catabolic process (GO:0010896)2.81980390
92dermatan sulfate biosynthetic process (GO:0030208)2.81575778
93dermatan sulfate metabolic process (GO:0030205)2.80943797
94regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.80752566
95substrate-dependent cell migration (GO:0006929)2.80632806
96regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.80517531
97high-density lipoprotein particle remodeling (GO:0034375)2.80348351
98negative regulation of protein localization to cell surface (GO:2000009)2.79895597
99positive regulation of fatty acid oxidation (GO:0046321)2.78065809
100glyoxylate metabolic process (GO:0046487)2.77447433
101reverse cholesterol transport (GO:0043691)2.76818839
102positive regulation of blood vessel endothelial cell migration (GO:0043536)2.75378814
103adhesion of symbiont to host (GO:0044406)2.74633816
104stress fiber assembly (GO:0043149)2.74483626
105peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.73801132
106phospholipid homeostasis (GO:0055091)2.72182927
107urea metabolic process (GO:0019627)2.72085056
108urea cycle (GO:0000050)2.72085056
109extracellular matrix organization (GO:0030198)2.71624327
110epoxygenase P450 pathway (GO:0019373)2.71213080
111bile acid biosynthetic process (GO:0006699)2.70838676
112extracellular structure organization (GO:0043062)2.70640929
113growth hormone receptor signaling pathway (GO:0060396)2.70479153
114positive regulation of receptor recycling (GO:0001921)2.70476911
115fatty acid transmembrane transport (GO:1902001)2.68445300
116blood vessel maturation (GO:0001955)2.67538630
117retina vasculature morphogenesis in camera-type eye (GO:0061299)2.65879746
118urate metabolic process (GO:0046415)2.65780182
119regulation of fibrinolysis (GO:0051917)2.64431878
120plasma lipoprotein particle clearance (GO:0034381)2.63933810
121muscle cell migration (GO:0014812)2.62629910
122kynurenine metabolic process (GO:0070189)2.62614500
123respiratory tube development (GO:0030323)2.62496757
124hormone catabolic process (GO:0042447)2.61490963
125drug catabolic process (GO:0042737)2.61435999
126positive regulation of osteoblast proliferation (GO:0033690)2.61419874
127regulation of fatty acid beta-oxidation (GO:0031998)2.60777052
128cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.60567705
129acylglycerol homeostasis (GO:0055090)2.59681843
130triglyceride homeostasis (GO:0070328)2.59681843
131bile acid metabolic process (GO:0008206)2.58219108
132hemidesmosome assembly (GO:0031581)2.57810995
133surfactant homeostasis (GO:0043129)2.57683524
134regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.57651112
135urinary tract smooth muscle contraction (GO:0014848)2.56933205
136planar cell polarity pathway involved in neural tube closure (GO:0090179)2.56772673
137indole-containing compound catabolic process (GO:0042436)2.55931962
138indolalkylamine catabolic process (GO:0046218)2.55931962
139tryptophan catabolic process (GO:0006569)2.55931962
140regulation of smooth muscle cell migration (GO:0014910)2.55877253
141fatty acid beta-oxidation (GO:0006635)2.55429149
142positive regulation of lipid catabolic process (GO:0050996)2.55137984
143endocrine hormone secretion (GO:0060986)2.55058082
144negative regulation of osteoblast proliferation (GO:0033689)2.54813713
145regulation of extracellular matrix disassembly (GO:0010715)2.54391680
146negative regulation of protein activation cascade (GO:2000258)2.54243630
147import into cell (GO:0098657)2.54157285
148endothelial cell morphogenesis (GO:0001886)2.53612378
149negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.53478305
150negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.53090094
151amino-acid betaine metabolic process (GO:0006577)2.52900297
152extracellular regulation of signal transduction (GO:1900115)2.52271096
153extracellular negative regulation of signal transduction (GO:1900116)2.52271096
154lymph vessel development (GO:0001945)2.48911349
155heme transport (GO:0015886)2.48656085
156positive regulation of fatty acid metabolic process (GO:0045923)2.48234582
157fatty acid oxidation (GO:0019395)2.48070691
158negative regulation of axon extension involved in axon guidance (GO:0048843)2.47168400
159insulin-like growth factor receptor signaling pathway (GO:0048009)2.46962031
160tryptophan metabolic process (GO:0006568)2.46470631
161negative regulation of protein autophosphorylation (GO:0031953)2.45168306
162fibrinolysis (GO:0042730)2.44762500
163nitrogen cycle metabolic process (GO:0071941)2.44349598
164cell-matrix adhesion (GO:0007160)2.44302873
165platelet degranulation (GO:0002576)2.43895524
1662-oxoglutarate metabolic process (GO:0006103)2.43696546
167negative regulation of sterol transport (GO:0032372)2.43619105
168negative regulation of cholesterol transport (GO:0032375)2.43619105
169cell-substrate adhesion (GO:0031589)2.43036061
170negative regulation of lipase activity (GO:0060192)2.42566917
171lipid oxidation (GO:0034440)2.42450531
172regulation of bile acid biosynthetic process (GO:0070857)2.41665150
173artery morphogenesis (GO:0048844)2.41525918
174drug metabolic process (GO:0017144)2.41476897
175cellular response to growth hormone stimulus (GO:0071378)2.41054186
176response to parathyroid hormone (GO:0071107)2.40799519
177regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.40355000
178plasma lipoprotein particle remodeling (GO:0034369)2.40093795
179protein-lipid complex remodeling (GO:0034368)2.40093795
180macromolecular complex remodeling (GO:0034367)2.40093795
181lipoprotein metabolic process (GO:0042157)2.39940821
182positive regulation of p38MAPK cascade (GO:1900745)2.39319063
183regulation of plasminogen activation (GO:0010755)2.39107652
184neuron projection extension involved in neuron projection guidance (GO:1902284)2.38665554
185axon extension involved in axon guidance (GO:0048846)2.38665554
186carnitine shuttle (GO:0006853)2.38566056
187keratan sulfate catabolic process (GO:0042340)2.38471805
188hyaluronan catabolic process (GO:0030214)2.38402701
189anterior/posterior axis specification, embryo (GO:0008595)2.37800930

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.41249991
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.37098976
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.01775587
4LXR_22158963_ChIP-Seq_LIVER_Mouse3.56106081
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.45907044
6SMAD_19615063_ChIP-ChIP_OVARY_Human3.23644038
7CLOCK_20551151_ChIP-Seq_293T_Human3.22246020
8TRIM28_21343339_ChIP-Seq_HEK293_Human3.17459765
9* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.54432262
10EGR1_23403033_ChIP-Seq_LIVER_Mouse2.43897669
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.42095805
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.32783970
13ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.32756535
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.18117692
15CDX2_19796622_ChIP-Seq_MESCs_Mouse2.12543650
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.10424750
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.05887882
18TP53_16413492_ChIP-PET_HCT116_Human1.98099761
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.93254048
20PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.91652410
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.88984435
22TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.77629012
23TP53_18474530_ChIP-ChIP_U2OS_Human1.76778665
24* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72795292
25EP300_21415370_ChIP-Seq_HL-1_Mouse1.68872529
26TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68522870
27ESR1_20079471_ChIP-ChIP_T-47D_Human1.67055094
28CDX2_20551321_ChIP-Seq_CACO-2_Human1.64521279
29BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.63687354
30GATA2_21666600_ChIP-Seq_HMVEC_Human1.58451350
31* WT1_19549856_ChIP-ChIP_CCG9911_Human1.58410821
32* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.58035470
33SOX2_27498859_Chip-Seq_STOMACH_Mouse1.56796581
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.49203063
35* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47596994
36* SOX2_20726797_ChIP-Seq_SW620_Human1.44920009
37* FOXA2_19822575_ChIP-Seq_HepG2_Human1.43688824
38CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.42691235
39CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.41793902
40CJUN_26792858_Chip-Seq_BT549_Human1.41336923
41FOXO3_23340844_ChIP-Seq_DLD1_Human1.41274606
42FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.40934332
43SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.39412978
44CTNNB1_20460455_ChIP-Seq_HCT116_Human1.38827164
45GATA1_22025678_ChIP-Seq_K562_Human1.37094941
46CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.37079506
47SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.32321814
48* GBX2_23144817_ChIP-Seq_PC3_Human1.30984095
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30209264
50JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29076736
51GATA4_25053715_ChIP-Seq_YYC3_Human1.28866737
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27879015
53NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.27013691
54NRF2_20460467_ChIP-Seq_MEFs_Mouse1.27013691
55NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.25861979
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25482158
57* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22972094
58SALL4_18804426_ChIP-ChIP_XEN_Mouse1.22699547
59Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.22387648
60* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22317989
61NFIB_24661679_ChIP-Seq_LUNG_Mouse1.21994125
62TBX20_22328084_ChIP-Seq_HEART_Mouse1.20739187
63TBX20_22080862_ChIP-Seq_HEART_Mouse1.20739187
64STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19806525
65SOX9_24532713_ChIP-Seq_HFSC_Mouse1.17352059
66IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.13834004
67ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12835540
68KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12700603
69* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11372498
70TP53_23651856_ChIP-Seq_MEFs_Mouse1.10041695
71HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.09859910
72RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09465113
73JARID2_20075857_ChIP-Seq_MESCs_Mouse1.08277682
74TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.07724509
75ZNF263_19887448_ChIP-Seq_K562_Human1.07540786
76SMC1_22415368_ChIP-Seq_MEFs_Mouse1.06801828
77EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.05130572
78SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.04890831
79SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.04790630
80SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03809690
81SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.03034003
82WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02714558
83PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02184380
84RACK7_27058665_Chip-Seq_MCF-7_Human1.01339076
85AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01221132
86MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.99958402
87RNF2_27304074_Chip-Seq_ESCs_Mouse0.99755212
88ISL1_27105846_Chip-Seq_CPCs_Mouse0.98961370
89AHR_22903824_ChIP-Seq_MCF-7_Human0.98658731
90RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98123594
91BCAT_22108803_ChIP-Seq_LS180_Human0.97780819
92SMAD4_21799915_ChIP-Seq_A2780_Human0.97703326
93TP53_22127205_ChIP-Seq_IMR90_Human0.96989356
94* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.96956476
95TCF4_18268006_ChIP-ChIP_LS174T_Human0.95986807
96TP63_23658742_ChIP-Seq_EP156T_Human0.94684193
97* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94507608
98RUNX1_27514584_Chip-Seq_MCF-7_Human0.94458915
99SA1_22415368_ChIP-Seq_MEFs_Mouse0.93805537
100PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.93020593
101EED_16625203_ChIP-ChIP_MESCs_Mouse0.92799511
102ELK3_25401928_ChIP-Seq_HUVEC_Human0.92239875
103SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.91626776
104ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90566831
105ERG_21242973_ChIP-ChIP_JURKAT_Human0.90429476
106GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.90179902
107* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.89709166
108* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.89504342
109* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.89504342
110DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88659719
111SMC3_22415368_ChIP-Seq_MEFs_Mouse0.88001662
112DROSHA_22980978_ChIP-Seq_HELA_Human0.87565994
113* HNF4A_19822575_ChIP-Seq_HepG2_Human0.87309852
114P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86950084
115JARID2_20064375_ChIP-Seq_MESCs_Mouse0.86875368
116GATA3_24758297_ChIP-Seq_MCF-7_Human0.86756583
117GATA6_25053715_ChIP-Seq_YYC3_Human0.86348417
118FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85854737
119EZH2_18974828_ChIP-Seq_MESCs_Mouse0.85670902
120RNF2_18974828_ChIP-Seq_MESCs_Mouse0.85670902
121ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85206017
122ARNT_22903824_ChIP-Seq_MCF-7_Human0.85112603
123UBF1/2_26484160_Chip-Seq_HMECs_Human0.84961798
124PIAS1_25552417_ChIP-Seq_VCAP_Human0.83796599
125ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.83618836
126STAT6_21828071_ChIP-Seq_BEAS2B_Human0.82979954
127MTF2_20144788_ChIP-Seq_MESCs_Mouse0.82398758
128JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82277662
129ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81269757
130SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.80807756
131SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.79691065
132HIF1A_21447827_ChIP-Seq_MCF-7_Human0.77750578
133* BRD4_25478319_ChIP-Seq_HGPS_Human0.76974164
134NR3C1_23031785_ChIP-Seq_PC12_Mouse0.76906118
135FOXM1_26456572_ChIP-Seq_MCF-7_Human0.76681324

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.08050133
2MP0002139_abnormal_hepatobiliary_system3.86620055
3MP0008438_abnormal_cutaneous_collagen3.71731274
4MP0005085_abnormal_gallbladder_physiolo3.31311509
5MP0005365_abnormal_bile_salt3.01650860
6MP0008875_abnormal_xenobiotic_pharmacok2.83535673
7MP0004272_abnormal_basement_membrane2.74304004
8MP0003252_abnormal_bile_duct2.66408298
9MP0003950_abnormal_plasma_membrane2.65611565
10MP0005275_abnormal_skin_tensile2.62098780
11MP0005257_abnormal_intraocular_pressure2.52333583
12MP0010368_abnormal_lymphatic_system2.51738160
13MP0003705_abnormal_hypodermis_morpholog2.49060012
14MP0001958_emphysema2.31426583
15MP0005367_renal/urinary_system_phenotyp2.24822272
16MP0000516_abnormal_urinary_system2.24822272
17MP0010329_abnormal_lipoprotein_level2.16438536
18MP0009384_cardiac_valve_regurgitation1.98865198
19MP0001879_abnormal_lymphatic_vessel1.95819720
20MP0001666_abnormal_nutrient_absorption1.90286231
21MP0005503_abnormal_tendon_morphology1.89757021
22MP0005508_abnormal_skeleton_morphology1.84690188
23MP0000462_abnormal_digestive_system1.84688371
24MP0006054_spinal_hemorrhage1.80083098
25MP0010234_abnormal_vibrissa_follicle1.76124703
26MP0003191_abnormal_cellular_cholesterol1.74796439
27MP0005332_abnormal_amino_acid1.68402630
28MP0000537_abnormal_urethra_morphology1.65821675
29* MP0001756_abnormal_urination1.61629298
30MP0002254_reproductive_system_inflammat1.56570243
31MP0000534_abnormal_ureter_morphology1.55967954
32MP0003941_abnormal_skin_development1.54461472
33MP0004019_abnormal_vitamin_homeostasis1.54031603
34MP0003300_gastrointestinal_ulcer1.47030341
35MP0000013_abnormal_adipose_tissue1.45413816
36MP0001299_abnormal_eye_distance/1.45217028
37MP0004130_abnormal_muscle_cell1.42622770
38MP0009643_abnormal_urine_homeostasis1.42022388
39MP0005167_abnormal_blood-brain_barrier1.40747312
40MP0003279_aneurysm1.40382815
41MP0003566_abnormal_cell_adhesion1.36289150
42MP0000538_abnormal_urinary_bladder1.33985348
43MP0001661_extended_life_span1.31547710
44MP0005666_abnormal_adipose_tissue1.30120216
45MP0004185_abnormal_adipocyte_glucose1.29434893
46* MP0000230_abnormal_systemic_arterial1.26960264
47MP0000767_abnormal_smooth_muscle1.26688536
48MP0005319_abnormal_enzyme/_coenzyme1.26570775
49MP0002837_dystrophic_cardiac_calcinosis1.26074065
50MP0002138_abnormal_hepatobiliary_system1.25723414
51MP0004147_increased_porphyrin_level1.25627142
52MP0008004_abnormal_stomach_pH1.25595876
53MP0002118_abnormal_lipid_homeostasis1.25562691
54MP0003011_delayed_dark_adaptation1.25010644
55MP0009250_abnormal_appendicular_skeleto1.24972591
56MP0000751_myopathy1.21959835
57MP0005670_abnormal_white_adipose1.19028186
58MP0003045_fibrosis1.16686516
59MP0002295_abnormal_pulmonary_circulatio1.16022395
60MP0006138_congestive_heart_failure1.16020765
61MP0005390_skeleton_phenotype1.14003861
62MP0004084_abnormal_cardiac_muscle1.13840185
63MP0001243_abnormal_dermal_layer1.13245836
64MP0002166_altered_tumor_susceptibility1.13229735
65MP0005375_adipose_tissue_phenotype1.11537491
66MP0001348_abnormal_lacrimal_gland1.11333879
67MP0000609_abnormal_liver_physiology1.09941817
68MP0005330_cardiomyopathy1.08384872
69MP0010030_abnormal_orbit_morphology1.05797414
70MP0005623_abnormal_meninges_morphology1.04068607
71MP0005164_abnormal_response_to1.03255138
72MP0003283_abnormal_digestive_organ1.03156087
73* MP0001664_abnormal_digestion1.01168215
74MP0000003_abnormal_adipose_tissue1.01067614
75MP0002136_abnormal_kidney_physiology0.99767382
76MP0003195_calcinosis0.99351250
77MP0000428_abnormal_craniofacial_morphol0.99340531
78MP0001849_ear_inflammation0.98648351
79MP0009840_abnormal_foam_cell0.97835982
80MP0002115_abnormal_skeleton_extremities0.96958944
81MP0005023_abnormal_wound_healing0.96633944
82MP0002060_abnormal_skin_morphology0.95998316
83MP0005595_abnormal_vascular_smooth0.94543967
84MP0002877_abnormal_melanocyte_morpholog0.94411249
85MP0000163_abnormal_cartilage_morphology0.92407771
86MP0000733_abnormal_muscle_development0.92265003
87MP0005647_abnormal_sex_gland0.91932598
88MP0005464_abnormal_platelet_physiology0.89646082
89MP0002168_other_aberrant_phenotype0.88457369
90MP0001765_abnormal_ion_homeostasis0.87985134
91MP0004858_abnormal_nervous_system0.86917107
92MP0002998_abnormal_bone_remodeling0.86352886
93MP0000762_abnormal_tongue_morphology0.85974941
94MP0004134_abnormal_chest_morphology0.85918341
95* MP0005620_abnormal_muscle_contractility0.85143276
96MP0002135_abnormal_kidney_morphology0.84277928
97MP0009053_abnormal_anal_canal0.83569033
98MP0002133_abnormal_respiratory_system0.83315735
99MP0005388_respiratory_system_phenotype0.83315735
100MP0000249_abnormal_blood_vessel0.82667051
101MP0001542_abnormal_bone_strength0.81879844
102MP0003115_abnormal_respiratory_system0.80331396
103MP0003868_abnormal_feces_composition0.79802533
104MP0002128_abnormal_blood_circulation0.79688745
105MP0004883_abnormal_blood_vessel0.79601607
106MP0002108_abnormal_muscle_morphology0.78497029
107MP0005171_absent_coat_pigmentation0.78260408
108MP0005083_abnormal_biliary_tract0.77899541
109MP0000749_muscle_degeneration0.77764268
110MP0002933_joint_inflammation0.77743989
111MP0003091_abnormal_cell_migration0.77581592
112MP0003828_pulmonary_edema0.76670330
113MP0005409_darkened_coat_color0.76269546
114MP0009764_decreased_sensitivity_to0.75818380
115MP0005187_abnormal_penis_morphology0.75355691
116MP0002896_abnormal_bone_mineralization0.73263282
117MP0002009_preneoplasia0.72750841
118* MP0004036_abnormal_muscle_relaxation0.72338117
119MP0001614_abnormal_blood_vessel0.70693169
120MP0001533_abnormal_skeleton_physiology0.70503867
121MP0000432_abnormal_head_morphology0.70374153
122MP0002282_abnormal_trachea_morphology0.69685687
123MP0005636_abnormal_mineral_homeostasis0.69421204
124MP0003942_abnormal_urinary_system0.69293237
125MP0001881_abnormal_mammary_gland0.69119379
126MP0009780_abnormal_chondrocyte_physiolo0.68359109
127MP0005197_abnormal_uvea_morphology0.67890314
128MP0001175_abnormal_lung_morphology0.67744735
129MP0005385_cardiovascular_system_phenoty0.67055143
130MP0001544_abnormal_cardiovascular_syste0.67055143
131MP0004264_abnormal_extraembryonic_tissu0.66882408
132MP0002113_abnormal_skeleton_development0.66493368
133MP0003385_abnormal_body_wall0.65866173
134MP0002925_abnormal_cardiovascular_devel0.65177435
135MP0010352_gastrointestinal_tract_polyps0.64222877
136MP0003724_increased_susceptibility_to0.63413443
137MP0005165_increased_susceptibility_to0.62708463
138MP0000759_abnormal_skeletal_muscle0.62179915
139MP0008775_abnormal_heart_ventricle0.62062158
140MP0003795_abnormal_bone_structure0.61159839
141MP0003448_altered_tumor_morphology0.59108153
142* MP0010386_abnormal_urinary_bladder0.56377427
143MP0005193_abnormal_anterior_eye0.55645616
144MP0004510_myositis0.55457934
145MP0001915_intracranial_hemorrhage0.54320112
146MP0004087_abnormal_muscle_fiber0.53819640

Predicted human phenotypes

RankGene SetZ-score
1* Aortic aneurysm (HP:0004942)5.59513689
2* Aortic dissection (HP:0002647)4.80776299
3Facial diplegia (HP:0001349)4.74650211
4Papilledema (HP:0001085)4.62024404
5Ankle contracture (HP:0006466)4.29947911
6Vascular tortuosity (HP:0004948)4.21164966
7Deep venous thrombosis (HP:0002625)4.01330130
8Soft skin (HP:0000977)3.85116819
9Increased density of long bones (HP:0006392)3.83027098
10Malnutrition (HP:0004395)3.78196540
11Arterial tortuosity (HP:0005116)3.67479156
12Cerebral aneurysm (HP:0004944)3.64655202
13Complement deficiency (HP:0004431)3.64345834
14Neonatal short-limb short stature (HP:0008921)3.63299122
15Broad metatarsal (HP:0001783)3.59364863
16Bladder diverticulum (HP:0000015)3.54576045
17Cervical subluxation (HP:0003308)3.47789007
18Wormian bones (HP:0002645)3.46348165
19Shallow orbits (HP:0000586)3.30313760
20Type 1 muscle fiber predominance (HP:0003803)3.29244877
21Mesangial abnormality (HP:0001966)3.11888814
22Intrahepatic cholestasis (HP:0001406)3.06932602
23Aortic regurgitation (HP:0001659)3.06307705
24Fragile skin (HP:0001030)3.03685454
25Gastrointestinal dysmotility (HP:0002579)3.00739269
26Abnormality of dentin (HP:0010299)2.99268881
27Spondylolisthesis (HP:0003302)2.98033054
28Long toe (HP:0010511)2.97728571
29Xanthomatosis (HP:0000991)2.89700836
30Protrusio acetabuli (HP:0003179)2.87450250
31Blue sclerae (HP:0000592)2.86753859
32Wide anterior fontanel (HP:0000260)2.86321629
33Right ventricular cardiomyopathy (HP:0011663)2.86166699
34Slender build (HP:0001533)2.83511815
35Focal segmental glomerulosclerosis (HP:0000097)2.78200374
36* Aneurysm (HP:0002617)2.76630742
37Peritonitis (HP:0002586)2.75932555
38Genu recurvatum (HP:0002816)2.69826126
39Neoplasm of the heart (HP:0100544)2.66749177
40Ulnar bowing (HP:0003031)2.65965451
41Joint laxity (HP:0001388)2.60909826
42Nephritis (HP:0000123)2.57110475
43Osteolytic defects of the phalanges of the hand (HP:0009771)2.56984378
44Osteolytic defects of the hand bones (HP:0009699)2.56984378
45Abnormality of monocarboxylic acid metabolism (HP:0010996)2.56580113
46Stroke (HP:0001297)2.56069369
47Rectal prolapse (HP:0002035)2.54321605
48Abnormality of glutamine family amino acid metabolism (HP:0010902)2.53439676
49Abnormality of complement system (HP:0005339)2.50532159
50Hypoventilation (HP:0002791)2.49328636
51Short hallux (HP:0010109)2.49087889
52Vertebral compression fractures (HP:0002953)2.45919943
53Increased connective tissue (HP:0009025)2.45441513
54Pigmentary retinal degeneration (HP:0001146)2.45207680
55Mitral regurgitation (HP:0001653)2.45041873
56Wrist flexion contracture (HP:0001239)2.40204462
57Mitral stenosis (HP:0001718)2.39555195
58Mitral valve prolapse (HP:0001634)2.39417666
59Abnormal platelet volume (HP:0011876)2.38524223
60Facial shape deformation (HP:0011334)2.37919889
61Potter facies (HP:0002009)2.37919889
62Lymphangioma (HP:0100764)2.37915288
63Bicuspid aortic valve (HP:0001647)2.37107646
64Bowel diverticulosis (HP:0005222)2.36894754
65Elbow flexion contracture (HP:0002987)2.36571518
66Biconcave vertebral bodies (HP:0004586)2.35165084
67Hyperextensible skin (HP:0000974)2.32994895
68Absent frontal sinuses (HP:0002688)2.32609892
69Premature rupture of membranes (HP:0001788)2.32393978
70Glomerulosclerosis (HP:0000096)2.31619756
71Cardiovascular calcification (HP:0011915)2.30836351
72Mesomelia (HP:0003027)2.29813568
73Camptodactyly of toe (HP:0001836)2.29386770
74Coronal craniosynostosis (HP:0004440)2.29339627
75Esophageal varix (HP:0002040)2.28355504
76Increased variability in muscle fiber diameter (HP:0003557)2.27365221
77Hyperlipoproteinemia (HP:0010980)2.24834377
78Follicular hyperkeratosis (HP:0007502)2.24703064
79Aplasia/Hypoplasia of the hallux (HP:0008362)2.23038952
80Polycythemia (HP:0001901)2.22127497
81Mild short stature (HP:0003502)2.22007882
82Abnormality of the common coagulation pathway (HP:0010990)2.21500648
83Overgrowth (HP:0001548)2.21281585
84Myocardial infarction (HP:0001658)2.20865585
85Hypoalphalipoproteinemia (HP:0003233)2.19894960
86Hyperglycinuria (HP:0003108)2.19709532
87Abnormal delivery (HP:0001787)2.19217983
88Spinal rigidity (HP:0003306)2.18910707
89Abnormality of the acetabulum (HP:0003170)2.17927139
90Abnormality of aromatic amino acid family metabolism (HP:0004338)2.17068034
91Spastic diplegia (HP:0001264)2.13873311
92Hematochezia (HP:0002573)2.12827176
93Aortic valve stenosis (HP:0001650)2.12797523
94Hypobetalipoproteinemia (HP:0003563)2.10600133
95Prolonged partial thromboplastin time (HP:0003645)2.10568246
96Vascular calcification (HP:0004934)2.10454187
97Abnormal foot bone ossification (HP:0010675)2.09836699
98Broad ribs (HP:0000885)2.08993008
99Menorrhagia (HP:0000132)2.08686839
100Dilatation of the ascending aorta (HP:0005111)2.08683785
101Glomerulonephritis (HP:0000099)2.07631260
102Abnormality of the intrinsic pathway (HP:0010989)2.07542312
103Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.07223654
104Limited hip movement (HP:0008800)2.06079084
105Epidermoid cyst (HP:0200040)2.05132678
106Hypoplasia of the iris (HP:0007676)2.04193448
107Hypolipoproteinemia (HP:0010981)2.02742689
108Hydroureter (HP:0000072)2.00895982
109Shawl scrotum (HP:0000049)2.00824770
110Short 4th metacarpal (HP:0010044)1.99567597
111Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.99567597
112Visceral angiomatosis (HP:0100761)1.98351815
113Natal tooth (HP:0000695)1.97467992
114Abnormal cartilage morphology (HP:0002763)1.97322402
115Hip contracture (HP:0003273)1.96184090
116Spontaneous abortion (HP:0005268)1.96087135
117Knee flexion contracture (HP:0006380)1.95738617
118Hemorrhage of the eye (HP:0011885)1.95694129
119Abnormality of proline metabolism (HP:0010907)1.95662233
120Hydroxyprolinuria (HP:0003080)1.95662233
121Broad face (HP:0000283)1.95555514
122Abnormality of the 4th metacarpal (HP:0010012)1.95166176
123Stridor (HP:0010307)1.95115729
124Hyperammonemia (HP:0001987)1.95044063
125Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.93478627
126Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.92275123
127Radial bowing (HP:0002986)1.91211079
128Short nail (HP:0001799)1.89834425
129Scapular winging (HP:0003691)1.89662866
130Ectopia lentis (HP:0001083)1.89078134
131Hyporeflexia of lower limbs (HP:0002600)1.88630105
132Pulmonary artery stenosis (HP:0004415)1.88169199
133Fat malabsorption (HP:0002630)1.87511699
134Ileus (HP:0002595)1.86450786
135Atrophic scars (HP:0001075)1.85326455
136Back pain (HP:0003418)1.85083259
137Ketosis (HP:0001946)1.85082089
138Joint stiffness (HP:0001387)1.84911302
139Increased mean platelet volume (HP:0011877)1.84630449
140Abnormality of skeletal muscle fiber size (HP:0012084)1.84479167
141Hemangiomatosis (HP:0007461)1.83793878
142Round ear (HP:0100830)1.83550373
143Mildly elevated creatine phosphokinase (HP:0008180)1.83337881
144Abnormal ossification of hand bones (HP:0005921)1.82877027
145Spinal cord lesions (HP:0100561)1.82869047
146Syringomyelia (HP:0003396)1.82869047
147Skin nodule (HP:0200036)1.81896500
148Persistence of primary teeth (HP:0006335)1.81863472
149Bowing of the arm (HP:0006488)1.81244842
150Bowed forearm bones (HP:0003956)1.81244842
151Delayed closure of the anterior fontanelle (HP:0001476)1.78910023
152Striae distensae (HP:0001065)1.76620967
153Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.74311402
154Short clavicles (HP:0000894)1.73891977
155Osteoarthritis (HP:0002758)1.72393795
156Infantile muscular hypotonia (HP:0008947)1.72197614
157Flared iliac wings (HP:0002869)1.71041900
158Bradycardia (HP:0001662)1.70025778
159Delayed cranial suture closure (HP:0000270)1.69935614
160Thoracolumbar scoliosis (HP:0002944)1.69932220
161Abnormality of skull ossification (HP:0002703)1.69208785
162Abnormality of carpal bone ossification (HP:0006257)1.67943527
163Arachnodactyly (HP:0001166)1.67599463
164Disproportionate tall stature (HP:0001519)1.67383627
165Protruding ear (HP:0000411)1.66684521
166Tibial bowing (HP:0002982)1.66238394

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.03252751
2* MYLK3.45107398
3DMPK3.40300241
4ERN12.85022713
5TIE12.63173925
6FRK2.60920042
7TRIB32.55628072
8SIK12.53739547
9PIK3CG2.53563727
10LATS12.51195622
11TGFBR22.37663377
12EPHB22.36021904
13AKT32.25171562
14PDGFRA2.23383202
15LMTK22.22822482
16RIPK12.15081002
17MST1R1.92849994
18DDR21.90910428
19TRPM71.89447563
20NUAK11.86759822
21LIMK11.80108643
22PIK3CA1.79239870
23BCKDK1.75595124
24NTRK11.75499117
25PRKD21.66614970
26PTK61.65368966
27STK381.62441905
28FGFR41.60593640
29FGFR21.47998399
30CAMK1D1.44390290
31FER1.43825334
32MET1.34750447
33WNK41.32655332
34EPHA31.23833051
35KDR1.21750990
36ADRBK11.20357257
37GRK71.20162122
38PTK2B1.18672774
39STK391.18479649
40PKN21.18372854
41ROCK11.14436533
42CAMK1G1.11232295
43TAOK31.10556181
44KIT1.09364999
45EPHB11.07858143
46* PAK21.04147179
47PTK21.01028760
48MAP3K60.99153595
49PDK20.96511533
50CDC42BPA0.95855326
51STK38L0.92925256
52GRK10.89522829
53INSRR0.87431011
54PDGFRB0.87399700
55MAPK70.87011823
56GRK50.84015931
57LRRK20.79952630
58MELK0.79926171
59EEF2K0.79646042
60TGFBR10.77785064
61TESK10.75601787
62DAPK30.75430492
63PAK30.75090421
64MST40.74164625
65PRKAA20.72686512
66MAP3K70.72106908
67FGFR30.70305311
68MAPKAPK30.70244088
69MAP3K20.69504797
70ERBB40.68240564
71JAK10.67218915
72MARK20.66670744
73MAP3K30.66138140
74PAK40.65786524
75ILK0.65484273
76STK30.65465467
77PRKG20.64294214
78RPS6KA20.62393001
79CDK120.61425658
80MAP2K10.60725744
81NEK90.60127566
82OXSR10.59735566
83CAMK10.59342771
84RET0.58830331
85NLK0.57562511
86LATS20.56011610
87MTOR0.53066278
88ZAP700.50903190
89TYK20.50371400
90BMX0.49924609
91PDK40.49709197
92PDK30.49709197
93JAK20.49418604
94PRKCE0.47390321
95SGK30.46578024
96PRKD10.46464405
97MAP2K30.44986250
98FLT30.43210123
99MAP2K20.42909111
100PAK60.42357931
101MAPK120.41393447
102ERBB20.40348678
103HIPK20.39755273
104RPS6KA60.38846330
105ICK0.38788194
106MAP3K100.37455737
107PRKCH0.37388025
108PDPK10.37175843
109EPHA20.36046303
110MAP2K40.35575868
111CSK0.35552564
112PRKAA10.35288136
113* PAK10.35234647
114CDK80.34721341
115* SRC0.33007892
116FGFR10.32949174
117ADRBK20.32441638
118IGF1R0.32387541
119MAPK110.32256069
120CAMK2B0.31184608
121MOS0.30832854
122CAMK2D0.30277164
123PRKG10.30208895
124INSR0.29998815
125FYN0.29621660
126ABL20.29240572
127WNK10.28799008
128RPS6KC10.27998203
129RPS6KL10.27998203
130* GSK3A0.27863594
131SGK20.27206313
132TBK10.27016374
133ROCK20.26984701

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.98448497
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.76557327
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.64562178
4Fatty acid degradation_Homo sapiens_hsa000712.53373977
5PPAR signaling pathway_Homo sapiens_hsa033202.38226780
6Complement and coagulation cascades_Homo sapiens_hsa046102.25602524
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.25320745
8Tryptophan metabolism_Homo sapiens_hsa003802.16039274
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.09371730
10Arginine biosynthesis_Homo sapiens_hsa002202.08002653
11Caffeine metabolism_Homo sapiens_hsa002322.07724443
12Sulfur metabolism_Homo sapiens_hsa009202.01122652
13Fatty acid metabolism_Homo sapiens_hsa012121.93221093
14Propanoate metabolism_Homo sapiens_hsa006401.92999176
15ECM-receptor interaction_Homo sapiens_hsa045121.90703255
16Bile secretion_Homo sapiens_hsa049761.89101194
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.87532031
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.81484434
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.76081281
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.72659972
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.72275900
22* Regulation of actin cytoskeleton_Homo sapiens_hsa048101.71150499
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.65325015
24Chemical carcinogenesis_Homo sapiens_hsa052041.57635162
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.53503283
26Fat digestion and absorption_Homo sapiens_hsa049751.53381651
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.52606959
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.49021428
29Histidine metabolism_Homo sapiens_hsa003401.47624224
30Protein digestion and absorption_Homo sapiens_hsa049741.45188681
31beta-Alanine metabolism_Homo sapiens_hsa004101.43031310
32Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.42643078
33ABC transporters_Homo sapiens_hsa020101.40766675
34Butanoate metabolism_Homo sapiens_hsa006501.40474218
35Peroxisome_Homo sapiens_hsa041461.39559234
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.31882420
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.29310840
38* Focal adhesion_Homo sapiens_hsa045101.29273515
39Gap junction_Homo sapiens_hsa045401.28901818
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.26026037
41Melanoma_Homo sapiens_hsa052181.23760293
42Starch and sucrose metabolism_Homo sapiens_hsa005001.23693538
43Retinol metabolism_Homo sapiens_hsa008301.19969691
44Pyruvate metabolism_Homo sapiens_hsa006201.19313092
45Staphylococcus aureus infection_Homo sapiens_hsa051501.18507634
46* Vascular smooth muscle contraction_Homo sapiens_hsa042701.11965512
47Phenylalanine metabolism_Homo sapiens_hsa003601.11515279
48Malaria_Homo sapiens_hsa051441.08936719
49Glycerolipid metabolism_Homo sapiens_hsa005611.06929158
50Fatty acid biosynthesis_Homo sapiens_hsa000611.06136563
51Phospholipase D signaling pathway_Homo sapiens_hsa040721.05096439
52MicroRNAs in cancer_Homo sapiens_hsa052061.02961911
53Hippo signaling pathway_Homo sapiens_hsa043901.02765253
54Amoebiasis_Homo sapiens_hsa051461.02735895
55Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.00908819
56Vitamin digestion and absorption_Homo sapiens_hsa049771.00479677
57Hedgehog signaling pathway_Homo sapiens_hsa043401.00275860
58Pathways in cancer_Homo sapiens_hsa052000.99069297
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98986737
60Rap1 signaling pathway_Homo sapiens_hsa040150.96280055
61Prostate cancer_Homo sapiens_hsa052150.94968365
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94609655
63Lysine degradation_Homo sapiens_hsa003100.94392452
64Tyrosine metabolism_Homo sapiens_hsa003500.94305656
65Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.92851558
66Glioma_Homo sapiens_hsa052140.91278860
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90097613
68Melanogenesis_Homo sapiens_hsa049160.88562877
69Renin-angiotensin system_Homo sapiens_hsa046140.88562086
70Insulin resistance_Homo sapiens_hsa049310.85822379
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83294683
72Selenocompound metabolism_Homo sapiens_hsa004500.80728830
73Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79109858
74Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78097513
75Basal cell carcinoma_Homo sapiens_hsa052170.78013991
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.76730137
77Axon guidance_Homo sapiens_hsa043600.76440071
78Chronic myeloid leukemia_Homo sapiens_hsa052200.76283249
79Carbon metabolism_Homo sapiens_hsa012000.72950483
80* Oxytocin signaling pathway_Homo sapiens_hsa049210.71840247
81Small cell lung cancer_Homo sapiens_hsa052220.71189544
82Mineral absorption_Homo sapiens_hsa049780.70139552
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69970737
84Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69633939
85Adherens junction_Homo sapiens_hsa045200.69338852
86GnRH signaling pathway_Homo sapiens_hsa049120.68719776
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68609294
88cAMP signaling pathway_Homo sapiens_hsa040240.68424177
89Ras signaling pathway_Homo sapiens_hsa040140.67749994
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.67341008
91Dilated cardiomyopathy_Homo sapiens_hsa054140.66848028
92* Calcium signaling pathway_Homo sapiens_hsa040200.66380954
93Endocytosis_Homo sapiens_hsa041440.65663614
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.65347099
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65339028
96Pancreatic secretion_Homo sapiens_hsa049720.64565079
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63688741
98Renal cell carcinoma_Homo sapiens_hsa052110.63143829
99Proteoglycans in cancer_Homo sapiens_hsa052050.63095210
100Tight junction_Homo sapiens_hsa045300.62670831
101Fatty acid elongation_Homo sapiens_hsa000620.62526093
102Other glycan degradation_Homo sapiens_hsa005110.62448592
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.62386958
104Phototransduction_Homo sapiens_hsa047440.61454977
105Estrogen signaling pathway_Homo sapiens_hsa049150.61363932
106Salivary secretion_Homo sapiens_hsa049700.61206760
107AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60870137
108Dorso-ventral axis formation_Homo sapiens_hsa043200.60648570
109Choline metabolism in cancer_Homo sapiens_hsa052310.60556628
110Pancreatic cancer_Homo sapiens_hsa052120.60293665
111Notch signaling pathway_Homo sapiens_hsa043300.58931127
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58863383
113Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.58435298
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58270582
115Glutathione metabolism_Homo sapiens_hsa004800.57169124
116Arachidonic acid metabolism_Homo sapiens_hsa005900.56872199
117Arginine and proline metabolism_Homo sapiens_hsa003300.56093649
118Cholinergic synapse_Homo sapiens_hsa047250.55393499
119MAPK signaling pathway_Homo sapiens_hsa040100.55215587
120Wnt signaling pathway_Homo sapiens_hsa043100.55124462
121Cocaine addiction_Homo sapiens_hsa050300.54180421
122Pertussis_Homo sapiens_hsa051330.52329340
123FoxO signaling pathway_Homo sapiens_hsa040680.50480152
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.49826055
125Renin secretion_Homo sapiens_hsa049240.49529958
126TNF signaling pathway_Homo sapiens_hsa046680.48795395
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48416866
128Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48396057
129Circadian rhythm_Homo sapiens_hsa047100.48384249
130Thyroid hormone synthesis_Homo sapiens_hsa049180.47781971
131Leukocyte transendothelial migration_Homo sapiens_hsa046700.47461175
132AMPK signaling pathway_Homo sapiens_hsa041520.47251533
133Serotonergic synapse_Homo sapiens_hsa047260.46419450
134Bladder cancer_Homo sapiens_hsa052190.45725441
135Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45606105
136Circadian entrainment_Homo sapiens_hsa047130.45485038
137Shigellosis_Homo sapiens_hsa051310.45369204
138Long-term depression_Homo sapiens_hsa047300.45084645
139mTOR signaling pathway_Homo sapiens_hsa041500.44491646
140Insulin secretion_Homo sapiens_hsa049110.44430008
141Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44324300
142Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44111904
143Ovarian steroidogenesis_Homo sapiens_hsa049130.43936421
144Endometrial cancer_Homo sapiens_hsa052130.42421704
145TGF-beta signaling pathway_Homo sapiens_hsa043500.42295052
146* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41738032
147Biosynthesis of amino acids_Homo sapiens_hsa012300.37958994
148PI3K-Akt signaling pathway_Homo sapiens_hsa041510.36279509
149Maturity onset diabetes of the young_Homo sapiens_hsa049500.36178586
150Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34388960
151Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34384207
152Folate biosynthesis_Homo sapiens_hsa007900.34085033
153Cysteine and methionine metabolism_Homo sapiens_hsa002700.32988342
154Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.29002412
155Prion diseases_Homo sapiens_hsa050200.27888346
156alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26911416
157* Platelet activation_Homo sapiens_hsa046110.26259250
158Galactose metabolism_Homo sapiens_hsa000520.25998556
159Toxoplasmosis_Homo sapiens_hsa051450.23847177
160Insulin signaling pathway_Homo sapiens_hsa049100.23042001
161Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.22106133
162Glucagon signaling pathway_Homo sapiens_hsa049220.22024869

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