MYH10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-10 (MYO10). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1layer formation in cerebral cortex (GO:0021819)4.45375724
2locomotory exploration behavior (GO:0035641)4.33292073
3synaptic vesicle maturation (GO:0016188)4.24527594
4regulation of short-term neuronal synaptic plasticity (GO:0048172)3.96483617
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.86091840
6synaptic vesicle docking involved in exocytosis (GO:0016081)3.76342176
7dendritic spine morphogenesis (GO:0060997)3.62115452
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.58490713
9vocalization behavior (GO:0071625)3.54463407
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.44136001
11axonal fasciculation (GO:0007413)3.35620739
12heterochromatin organization (GO:0070828)3.34186840
13positive regulation of synapse maturation (GO:0090129)3.33902840
14exploration behavior (GO:0035640)3.32512628
15regulation of synapse structural plasticity (GO:0051823)3.27376812
16cell migration in hindbrain (GO:0021535)3.25501332
17regulation of glutamate receptor signaling pathway (GO:1900449)3.19617009
18regulation of posttranscriptional gene silencing (GO:0060147)3.12853076
19regulation of gene silencing by miRNA (GO:0060964)3.12853076
20regulation of gene silencing by RNA (GO:0060966)3.12853076
21DNA unwinding involved in DNA replication (GO:0006268)3.11623961
22glutamate secretion (GO:0014047)3.11577743
23notochord development (GO:0030903)3.10447159
24dendrite morphogenesis (GO:0048813)3.09574586
25presynaptic membrane assembly (GO:0097105)3.07379028
26cell communication by electrical coupling (GO:0010644)3.05924497
27convergent extension (GO:0060026)3.05386803
28cytoskeletal anchoring at plasma membrane (GO:0007016)3.05178770
29synaptic vesicle exocytosis (GO:0016079)3.04708094
30neuron recognition (GO:0008038)3.03618681
31pre-miRNA processing (GO:0031054)3.03417971
32regulation of long-term neuronal synaptic plasticity (GO:0048169)2.99140741
33regulation of dendritic spine morphogenesis (GO:0061001)2.97160207
34lung-associated mesenchyme development (GO:0060484)2.96062212
35hippo signaling (GO:0035329)2.95654700
36regulation of synaptic vesicle exocytosis (GO:2000300)2.94399446
37nuclear pore complex assembly (GO:0051292)2.94382208
38L-serine metabolic process (GO:0006563)2.93165454
39protein localization to synapse (GO:0035418)2.91467146
40dorsal/ventral axis specification (GO:0009950)2.87971560
41insulin-like growth factor receptor signaling pathway (GO:0048009)2.86464052
42cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.85749152
43neuron projection extension involved in neuron projection guidance (GO:1902284)2.85658187
44axon extension involved in axon guidance (GO:0048846)2.85658187
45regulation of neuronal synaptic plasticity (GO:0048168)2.84641743
46establishment of integrated proviral latency (GO:0075713)2.84539334
47activation of protein kinase A activity (GO:0034199)2.84103320
48* neuromuscular process controlling balance (GO:0050885)2.82767942
49G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.80766698
50negative regulation of catenin import into nucleus (GO:0035414)2.80683348
51protein localization to kinetochore (GO:0034501)2.78480600
52neurotransmitter secretion (GO:0007269)2.77832397
53central nervous system projection neuron axonogenesis (GO:0021952)2.76321127
54positive regulation of fibroblast migration (GO:0010763)2.75234363
55* establishment of nucleus localization (GO:0040023)2.73998916
56nuclear pore organization (GO:0006999)2.73405974
57mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.73116339
58presynaptic membrane organization (GO:0097090)2.71756096
59ionotropic glutamate receptor signaling pathway (GO:0035235)2.66396069
60paraxial mesoderm development (GO:0048339)2.65129316
61proline transport (GO:0015824)2.63581542
62mitotic sister chromatid cohesion (GO:0007064)2.62965054
63regulation of axon extension involved in axon guidance (GO:0048841)2.62882317
64planar cell polarity pathway involved in neural tube closure (GO:0090179)2.62513287
65positive regulation of dendritic spine morphogenesis (GO:0061003)2.62067421
66lateral sprouting from an epithelium (GO:0060601)2.61922879
67dendritic spine organization (GO:0097061)2.60447616
68sister chromatid segregation (GO:0000819)2.60256371
69axon extension (GO:0048675)2.58822736
70regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.58358648
71chondrocyte proliferation (GO:0035988)2.57990478
72sodium ion export (GO:0071436)2.56596908
73membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.54190533
74negative regulation of translation, ncRNA-mediated (GO:0040033)2.53247790
75regulation of translation, ncRNA-mediated (GO:0045974)2.53247790
76negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.53247790
77cerebellar Purkinje cell differentiation (GO:0021702)2.52900549
78regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.51678236
79chromatin remodeling at centromere (GO:0031055)2.50130654
80polarized epithelial cell differentiation (GO:0030859)2.50115638
81positive regulation of dendrite morphogenesis (GO:0050775)2.48935883
82establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.48864239
83mitotic sister chromatid segregation (GO:0000070)2.48170962
84nucleosome disassembly (GO:0006337)2.47960039
85protein-DNA complex disassembly (GO:0032986)2.47960039
86positive regulation of SMAD protein import into nucleus (GO:0060391)2.46789681
87outer ear morphogenesis (GO:0042473)2.46685439
88pyrimidine nucleobase catabolic process (GO:0006208)2.45788021
89innervation (GO:0060384)2.45676051
90auditory behavior (GO:0031223)2.44768025
91vesicle transport along microtubule (GO:0047496)2.43663554
92regulation of cell fate specification (GO:0042659)2.41595333
93regulation of axon guidance (GO:1902667)2.41436732
94glucocorticoid receptor signaling pathway (GO:0042921)2.41327349
95neuron cell-cell adhesion (GO:0007158)2.41258615
96body morphogenesis (GO:0010171)2.41160855
97regulation of synaptic vesicle transport (GO:1902803)2.41134684
98ATP-dependent chromatin remodeling (GO:0043044)2.39458057
99sequestering of extracellular ligand from receptor (GO:0035581)2.39330385
100synaptic transmission, glutamatergic (GO:0035249)2.39292173
101regulation of non-canonical Wnt signaling pathway (GO:2000050)2.38689036
102positive regulation of axon extension (GO:0045773)2.37498375
103regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.37250266
104prepulse inhibition (GO:0060134)2.36302730
105regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.34382405
106negative regulation of axon extension involved in axon guidance (GO:0048843)2.34240103
107neuron projection extension (GO:1990138)2.33714836
108DNA topological change (GO:0006265)2.33371290
109establishment of monopolar cell polarity (GO:0061162)2.32588340
110establishment or maintenance of monopolar cell polarity (GO:0061339)2.32588340
111glutamate receptor signaling pathway (GO:0007215)2.32187659
112long-term memory (GO:0007616)2.31017877
113regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.30369871
114regulation of synapse maturation (GO:0090128)2.29989864
115protein localization to chromosome, centromeric region (GO:0071459)2.29786131
116negative regulation of sodium ion transport (GO:0010766)2.29074204
117CENP-A containing nucleosome assembly (GO:0034080)2.28862415
118clathrin coat assembly (GO:0048268)2.28506805
119gamma-aminobutyric acid transport (GO:0015812)2.28238045
120gastrulation with mouth forming second (GO:0001702)2.28046726
121adherens junction assembly (GO:0034333)2.27939870
122apical protein localization (GO:0045176)2.27852695
123organelle transport along microtubule (GO:0072384)2.27569582
124peptidyl-lysine dimethylation (GO:0018027)2.27566045
125regulation of NFAT protein import into nucleus (GO:0051532)2.27402269
126generation of neurons (GO:0048699)2.27232198
127neurotransmitter-gated ion channel clustering (GO:0072578)2.27103677
128inner ear receptor cell development (GO:0060119)2.26934301
129ephrin receptor signaling pathway (GO:0048013)2.26727495
130positive regulation of dendrite development (GO:1900006)2.25825797
131neuronal ion channel clustering (GO:0045161)2.25654232
132regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.25464453
133neuron-neuron synaptic transmission (GO:0007270)2.25342927
134negative regulation of organelle assembly (GO:1902116)2.25194686
135double-strand break repair via nonhomologous end joining (GO:0006303)2.24880059
136non-recombinational repair (GO:0000726)2.24880059
137Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.24474186
138stress fiber assembly (GO:0043149)2.24287579
139negative regulation of microtubule polymerization (GO:0031115)2.23863715
140bone trabecula formation (GO:0060346)2.23674421
141mitotic metaphase plate congression (GO:0007080)2.22344041
142synapse organization (GO:0050808)2.22310011
143embryonic foregut morphogenesis (GO:0048617)2.22118740
144negative regulation of cytosolic calcium ion concentration (GO:0051481)2.21550921
145limb bud formation (GO:0060174)2.21078345
146synaptic vesicle endocytosis (GO:0048488)2.20211309
147DNA ligation (GO:0006266)2.20104713
148regulation of clathrin-mediated endocytosis (GO:2000369)2.20073362
149regulation of dendrite morphogenesis (GO:0048814)2.19653549
150artery development (GO:0060840)2.19544170
151camera-type eye morphogenesis (GO:0048593)2.19426080
152DNA replication-independent nucleosome assembly (GO:0006336)2.19132576
153DNA replication-independent nucleosome organization (GO:0034724)2.19132576
154DNA strand renaturation (GO:0000733)2.17741764
155regulation of establishment of planar polarity (GO:0090175)2.16321061
156negative regulation of chondrocyte differentiation (GO:0032331)2.15431992
157non-canonical Wnt signaling pathway (GO:0035567)2.15179392
158ectodermal placode formation (GO:0060788)2.14471715
159kinetochore organization (GO:0051383)2.14403110
160postsynaptic membrane organization (GO:0001941)2.14306228
161DNA damage response, detection of DNA damage (GO:0042769)2.14240058
162metaphase plate congression (GO:0051310)2.13953801
163regulation of centriole replication (GO:0046599)2.13313190
164histone exchange (GO:0043486)2.13106825
165establishment of apical/basal cell polarity (GO:0035089)2.11742178
166protein complex localization (GO:0031503)2.11291143
167mitotic chromosome condensation (GO:0007076)2.08924949
168mesenchymal to epithelial transition (GO:0060231)2.08888217
169olfactory bulb development (GO:0021772)2.08251447
170anterior/posterior axis specification, embryo (GO:0008595)2.06611969
171regulation of sister chromatid cohesion (GO:0007063)2.05740881
172pore complex assembly (GO:0046931)2.05297094
173somatic stem cell division (GO:0048103)2.04220639
174NLS-bearing protein import into nucleus (GO:0006607)2.03284827
175neural tube closure (GO:0001843)2.02903850
176tube closure (GO:0060606)2.02871008
177cell migration involved in sprouting angiogenesis (GO:0002042)2.02008649
178cell fate commitment involved in formation of primary germ layer (GO:0060795)2.01914143
179spinal cord development (GO:0021510)2.01690065
180negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.00622441
181DNA strand elongation involved in DNA replication (GO:0006271)1.99190074
182spindle checkpoint (GO:0031577)1.97924682
183neural tube development (GO:0021915)1.97150745

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.85747820
2EZH2_22144423_ChIP-Seq_EOC_Human4.67156147
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.81017800
4RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60032500
5EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60032500
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.54176281
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.51270378
8* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.47490632
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.40001173
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.35569880
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.29155501
12WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.23333534
13* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.20787719
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.20225061
15RARB_27405468_Chip-Seq_BRAIN_Mouse2.16088374
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14006120
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.11570499
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.11155854
19DROSHA_22980978_ChIP-Seq_HELA_Human2.10533200
20POU5F1_16153702_ChIP-ChIP_HESCs_Human2.07590315
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.07165329
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.06951592
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.06463655
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.03124008
25* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.00973544
26AR_21909140_ChIP-Seq_LNCAP_Human2.00214436
27TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.95688265
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.93947606
29MTF2_20144788_ChIP-Seq_MESCs_Mouse1.92496163
30* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.92084918
31RBPJ_22232070_ChIP-Seq_NCS_Mouse1.91298256
32* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.86092184
33GBX2_23144817_ChIP-Seq_PC3_Human1.85657390
34EZH2_27294783_Chip-Seq_ESCs_Mouse1.81467646
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.76334135
36SOX2_16153702_ChIP-ChIP_HESCs_Human1.75700468
37* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.75452152
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.73085673
39POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.72906957
40ZNF274_21170338_ChIP-Seq_K562_Hela1.72809947
41SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.65420481
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.64051459
43REST_21632747_ChIP-Seq_MESCs_Mouse1.62208194
44SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.59947013
45FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.58775514
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.58231793
47HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.56862964
48NANOG_16153702_ChIP-ChIP_HESCs_Human1.55828773
49* RING1B_27294783_Chip-Seq_NPCs_Mouse1.55780843
50KDM2B_26808549_Chip-Seq_K562_Human1.55436351
51SOX2_18555785_ChIP-Seq_MESCs_Mouse1.54542918
52FUS_26573619_Chip-Seq_HEK293_Human1.52507230
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.51906792
54PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49709514
55RING1B_27294783_Chip-Seq_ESCs_Mouse1.49190356
56MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.48874438
57MYC_18555785_ChIP-Seq_MESCs_Mouse1.46792279
58TP63_19390658_ChIP-ChIP_HaCaT_Human1.46041855
59ISL1_27105846_Chip-Seq_CPCs_Mouse1.40328038
60TRIM28_21343339_ChIP-Seq_HEK293_Human1.38582067
61WT1_25993318_ChIP-Seq_PODOCYTE_Human1.37728344
62FOXM1_23109430_ChIP-Seq_U2OS_Human1.36264034
63GATA1_26923725_Chip-Seq_HPCs_Mouse1.35439867
64REST_18959480_ChIP-ChIP_MESCs_Mouse1.35117300
65TP53_20018659_ChIP-ChIP_R1E_Mouse1.35062643
66EWS_26573619_Chip-Seq_HEK293_Human1.33257394
67IGF1R_20145208_ChIP-Seq_DFB_Human1.31507033
68STAT6_21828071_ChIP-Seq_BEAS2B_Human1.30805251
69* SOX9_26525672_Chip-Seq_HEART_Mouse1.30242194
70EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.30038817
71* EP300_21415370_ChIP-Seq_HL-1_Mouse1.30013762
72KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.29324444
73KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.29324444
74KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.29324444
75* AR_19668381_ChIP-Seq_PC3_Human1.26271859
76SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.26137522
77ESR1_15608294_ChIP-ChIP_MCF-7_Human1.24415180
78SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.23128699
79RNF2_27304074_Chip-Seq_NSC_Mouse1.23072334
80NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.22973492
81TAF15_26573619_Chip-Seq_HEK293_Human1.22050750
82* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21765309
83YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21435876
84P300_19829295_ChIP-Seq_ESCs_Human1.19299716
85CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19154588
86STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.18624467
87AR_21572438_ChIP-Seq_LNCaP_Human1.18084969
88HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16796180
89NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.16697607
90IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16167510
91CBX2_27304074_Chip-Seq_ESCs_Mouse1.15763629
92TCF3_18692474_ChIP-Seq_MESCs_Mouse1.15140824
93* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15089457
94FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.14989171
95TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14410698
96E2F1_21310950_ChIP-Seq_MCF-7_Human1.14287279
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13847705
98PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.13192861
99TCF3_18692474_ChIP-Seq_MEFs_Mouse1.13127144
100* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11750608
101MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11071370
102ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10251707
103SOX2_21211035_ChIP-Seq_LN229_Gbm1.09400978
104TP53_16413492_ChIP-PET_HCT116_Human1.09095313
105ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07204872
106PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06733301
107WT1_19549856_ChIP-ChIP_CCG9911_Human1.06286186
108PIAS1_25552417_ChIP-Seq_VCAP_Human1.05777961
109OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.05489587
110MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.05428450
111* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04461137
112KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04286580
113NANOG_21062744_ChIP-ChIP_HESCs_Human1.02952302
114PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02405902
115TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02299327
116* KDM2B_26808549_Chip-Seq_JURKAT_Human1.01937399
117TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.01872021
118* SMAD4_21799915_ChIP-Seq_A2780_Human1.01095061
119* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.99355602
120MYC_19079543_ChIP-ChIP_MESCs_Mouse0.99272691
121RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99239653
122RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98828320
123MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.98404289
124TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98247975
125POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98247975
126KDM2B_26808549_Chip-Seq_DND41_Human0.97321852
127* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97095654
128* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.96789500
129DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94804388
130MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94254524
131TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94140216
132CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.91905632
133OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91700886
134BMI1_23680149_ChIP-Seq_NPCS_Mouse0.91574378
135MYC_19030024_ChIP-ChIP_MESCs_Mouse0.91540195
136NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.90182041
137SMAD4_21741376_ChIP-Seq_HESCs_Human0.89522057
138NR3C1_23031785_ChIP-Seq_PC12_Mouse0.89182868
139SMAD3_21741376_ChIP-Seq_EPCs_Human0.89061373
140ARNT_22903824_ChIP-Seq_MCF-7_Human0.88594108
141AHR_22903824_ChIP-Seq_MCF-7_Human0.88519681
142ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.88517652
143TBX3_20139965_ChIP-Seq_ESCs_Mouse0.88425909
144POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.88095109
145TBX3_20139965_ChIP-Seq_MESCs_Mouse0.87686041
146TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.87490227
147NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.87387183
148SMAD3_21741376_ChIP-Seq_ESCs_Human0.86390690
149SMAD3_21741376_ChIP-Seq_HESCs_Human0.85576441
150* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.83775781

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.26354271
2MP0003122_maternal_imprinting2.92482985
3MP0005623_abnormal_meninges_morphology2.63207646
4MP0003123_paternal_imprinting2.47421055
5MP0003635_abnormal_synaptic_transmissio2.43145095
6MP0003705_abnormal_hypodermis_morpholog2.23282296
7MP0000537_abnormal_urethra_morphology2.19196994
8MP0000566_synostosis2.13663183
9MP0006292_abnormal_olfactory_placode2.07024655
10MP0003385_abnormal_body_wall2.05002057
11MP0003283_abnormal_digestive_organ2.03554007
12MP0008438_abnormal_cutaneous_collagen2.01882393
13MP0010030_abnormal_orbit_morphology2.00590446
14MP0001293_anophthalmia1.98385200
15MP0003121_genomic_imprinting1.98218704
16MP0004270_analgesia1.97483591
17MP0003880_abnormal_central_pattern1.94976968
18MP0002938_white_spotting1.94910099
19MP0002063_abnormal_learning/memory/cond1.92585383
20MP0002697_abnormal_eye_size1.79151641
21MP0003136_yellow_coat_color1.77895191
22MP0004233_abnormal_muscle_weight1.75761444
23MP0009780_abnormal_chondrocyte_physiolo1.74410038
24MP0000778_abnormal_nervous_system1.73684310
25MP0009046_muscle_twitch1.69681932
26MP0000534_abnormal_ureter_morphology1.67712334
27MP0005503_abnormal_tendon_morphology1.65369311
28MP0009053_abnormal_anal_canal1.63133492
29MP0009745_abnormal_behavioral_response1.61614910
30MP0000569_abnormal_digit_pigmentation1.57970522
31MP0003942_abnormal_urinary_system1.54163055
32MP0008932_abnormal_embryonic_tissue1.53018947
33MP0004272_abnormal_basement_membrane1.51843429
34MP0009672_abnormal_birth_weight1.51485506
35MP0005257_abnormal_intraocular_pressure1.50989909
36MP0003111_abnormal_nucleus_morphology1.49218622
37MP0004858_abnormal_nervous_system1.45430711
38MP0010094_abnormal_chromosome_stability1.45428792
39MP0005423_abnormal_somatic_nervous1.43907889
40MP0004133_heterotaxia1.43299682
41MP0002064_seizures1.43191141
42MP0005187_abnormal_penis_morphology1.41964161
43MP0003115_abnormal_respiratory_system1.41253145
44MP0001299_abnormal_eye_distance/1.39894015
45MP0002184_abnormal_innervation1.39841222
46MP0003119_abnormal_digestive_system1.38454371
47MP0001286_abnormal_eye_development1.37824612
48MP0003693_abnormal_embryo_hatching1.36833889
49MP0004957_abnormal_blastocyst_morpholog1.34805719
50MP0002572_abnormal_emotion/affect_behav1.33254514
51* MP0004811_abnormal_neuron_physiology1.33197720
52MP0003787_abnormal_imprinting1.33172604
53MP0000751_myopathy1.32320809
54MP0008877_abnormal_DNA_methylation1.30587771
55MP0009250_abnormal_appendicular_skeleto1.29143986
56MP0002734_abnormal_mechanical_nocicepti1.28383536
57MP0000428_abnormal_craniofacial_morphol1.26176147
58MP0004145_abnormal_muscle_electrophysio1.24125257
59MP0001968_abnormal_touch/_nociception1.22672574
60* MP0003861_abnormal_nervous_system1.21405785
61MP0002092_abnormal_eye_morphology1.20423140
62MP0003935_abnormal_craniofacial_develop1.18192683
63MP0005275_abnormal_skin_tensile1.18114765
64MP0009703_decreased_birth_body1.16372919
65MP0003755_abnormal_palate_morphology1.15671470
66* MP0000955_abnormal_spinal_cord1.15620060
67MP0002822_catalepsy1.14826382
68MP0003938_abnormal_ear_development1.14771130
69MP0001486_abnormal_startle_reflex1.14746882
70MP0005076_abnormal_cell_differentiation1.12006179
71MP0005499_abnormal_olfactory_system1.11954730
72MP0005394_taste/olfaction_phenotype1.11954730
73MP0003937_abnormal_limbs/digits/tail_de1.11486011
74* MP0002152_abnormal_brain_morphology1.11091088
75MP0005171_absent_coat_pigmentation1.10888893
76MP0001529_abnormal_vocalization1.10731951
77MP0001730_embryonic_growth_arrest1.09671825
78MP0001672_abnormal_embryogenesis/_devel1.09213570
79MP0005380_embryogenesis_phenotype1.09213570
80MP0003077_abnormal_cell_cycle1.08369663
81MP0008057_abnormal_DNA_replication1.08201926
82MP0000049_abnormal_middle_ear1.06708673
83MP0002111_abnormal_tail_morphology1.06254115
84MP0001177_atelectasis1.05308854
85MP0000432_abnormal_head_morphology1.05221070
86MP0002932_abnormal_joint_morphology1.04880866
87MP0008789_abnormal_olfactory_epithelium1.02415376
88MP0003279_aneurysm1.02208043
89MP0004084_abnormal_cardiac_muscle1.01592401
90MP0002282_abnormal_trachea_morphology1.00869852
91MP0010368_abnormal_lymphatic_system1.00628555
92MP0003984_embryonic_growth_retardation1.00443696
93MP0002102_abnormal_ear_morphology1.00017579
94MP0002084_abnormal_developmental_patter0.99446964
95MP0002234_abnormal_pharynx_morphology0.98774456
96MP0000733_abnormal_muscle_development0.98298667
97MP0000013_abnormal_adipose_tissue0.97976030
98MP0003137_abnormal_impulse_conducting0.97874827
99MP0001348_abnormal_lacrimal_gland0.97829390
100MP0001958_emphysema0.97740942
101MP0002088_abnormal_embryonic_growth/wei0.96928891
102MP0000631_abnormal_neuroendocrine_gland0.96912285
103MP0002557_abnormal_social/conspecific_i0.96165538
104MP0001697_abnormal_embryo_size0.95984773
105MP0004197_abnormal_fetal_growth/weight/0.95769381
106MP0002272_abnormal_nervous_system0.95410888
107MP0002249_abnormal_larynx_morphology0.95339760
108* MP0002882_abnormal_neuron_morphology0.95054283
109MP0010352_gastrointestinal_tract_polyps0.94972828
110* MP0002116_abnormal_craniofacial_bone0.94860904
111MP0005248_abnormal_Harderian_gland0.94578779
112MP0009697_abnormal_copulation0.94163244
113MP0002751_abnormal_autonomic_nervous0.94121713
114MP0001984_abnormal_olfaction0.94096003
115MP0008569_lethality_at_weaning0.92340339
116MP0002653_abnormal_ependyma_morphology0.92209089
117MP0006276_abnormal_autonomic_nervous0.91690979
118* MP0002081_perinatal_lethality0.90568949
119MP0002233_abnormal_nose_morphology0.90399436
120MP0000579_abnormal_nail_morphology0.90364336
121MP0002089_abnormal_postnatal_growth/wei0.89891560
122MP0003941_abnormal_skin_development0.89836323
123MP0002108_abnormal_muscle_morphology0.87923888
124MP0002909_abnormal_adrenal_gland0.87886389
125MP0003315_abnormal_perineum_morphology0.87631330
126MP0002067_abnormal_sensory_capabilities0.87519783
127MP0005377_hearing/vestibular/ear_phenot0.87016439
128MP0003878_abnormal_ear_physiology0.87016439
129MP0004085_abnormal_heartbeat0.86767898
130MP0002085_abnormal_embryonic_tissue0.85053739
131MP0005386_behavior/neurological_phenoty0.84948259
132MP0004924_abnormal_behavior0.84948259
133MP0002114_abnormal_axial_skeleton0.84636699
134MP0005391_vision/eye_phenotype0.84456196
135MP0008058_abnormal_DNA_repair0.84219802
136MP0002733_abnormal_thermal_nociception0.83789414
137MP0004215_abnormal_myocardial_fiber0.83206691
138MP0001346_abnormal_lacrimal_gland0.83070828
139MP0001188_hyperpigmentation0.82826290
140MP0000462_abnormal_digestive_system0.82292122
141MP0001440_abnormal_grooming_behavior0.81434541
142MP0004885_abnormal_endolymph0.81081732
143MP0003890_abnormal_embryonic-extraembry0.80538502
144MP0005367_renal/urinary_system_phenotyp0.79362617
145MP0000516_abnormal_urinary_system0.79362617
146MP0009384_cardiac_valve_regurgitation0.78781112
147MP0002896_abnormal_bone_mineralization0.78465715
148MP0005508_abnormal_skeleton_morphology0.78422464
149MP0010234_abnormal_vibrissa_follicle0.78251011
150MP0003567_abnormal_fetal_cardiomyocyte0.78104312
151* MP0002066_abnormal_motor_capabilities/c0.77188062
152MP0002254_reproductive_system_inflammat0.76320336

Predicted human phenotypes

RankGene SetZ-score
1Shallow orbits (HP:0000586)3.59592667
2Protrusio acetabuli (HP:0003179)3.32155288
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.28596975
4Short 4th metacarpal (HP:0010044)3.28596975
5Renal duplication (HP:0000075)3.08848961
6Myokymia (HP:0002411)3.04303297
7Cortical dysplasia (HP:0002539)2.96879511
8Abnormality of the labia minora (HP:0012880)2.73965927
9Abnormality of the 4th metacarpal (HP:0010012)2.63559521
10Focal seizures (HP:0007359)2.57794316
11Pointed chin (HP:0000307)2.53524573
12Bladder diverticulum (HP:0000015)2.52526174
13Hyperacusis (HP:0010780)2.51426640
14Hepatoblastoma (HP:0002884)2.50215262
15Colon cancer (HP:0003003)2.49882565
16High anterior hairline (HP:0009890)2.49430522
17Bowel diverticulosis (HP:0005222)2.46239727
18Premature rupture of membranes (HP:0001788)2.44990763
19Focal motor seizures (HP:0011153)2.43926277
20Abnormality of the lower motor neuron (HP:0002366)2.39822794
21Insomnia (HP:0100785)2.37437870
22Cerebral aneurysm (HP:0004944)2.36093349
23Septo-optic dysplasia (HP:0100842)2.30632479
24Buphthalmos (HP:0000557)2.24821131
25Renovascular hypertension (HP:0100817)2.22517431
26Vitreoretinal degeneration (HP:0000655)2.17596829
27Elfin facies (HP:0004428)2.17540816
28Broad metatarsal (HP:0001783)2.16162212
29Action tremor (HP:0002345)2.13567876
30Overgrowth (HP:0001548)2.10601568
31Bifid tongue (HP:0010297)2.07875792
32Visual hallucinations (HP:0002367)2.07597183
33Abnormal lung lobation (HP:0002101)2.07205690
34Overriding aorta (HP:0002623)2.06130436
35Flat cornea (HP:0007720)2.05902949
36Aplasia/Hypoplasia of the sternum (HP:0006714)2.04553999
37Dilatation of the ascending aorta (HP:0005111)2.03890313
38Annular pancreas (HP:0001734)2.03216967
39Ankyloglossia (HP:0010296)2.00391200
40Ankle contracture (HP:0006466)1.99431254
41Partial duplication of thumb phalanx (HP:0009944)1.98880950
42Choanal stenosis (HP:0000452)1.98478737
43Insidious onset (HP:0003587)1.96307541
44Termporal pattern (HP:0011008)1.96307541
45Genu recurvatum (HP:0002816)1.95591430
46Abnormality of the aortic arch (HP:0012303)1.94938249
47Deviation of the hallux (HP:0010051)1.94121886
48Sacral dimple (HP:0000960)1.93001177
49Anophthalmia (HP:0000528)1.92219868
50Intestinal atresia (HP:0011100)1.90767610
51Preaxial foot polydactyly (HP:0001841)1.90609765
52Nephroblastoma (Wilms tumor) (HP:0002667)1.89429014
53Neonatal short-limb short stature (HP:0008921)1.89423282
54Bilateral microphthalmos (HP:0007633)1.89196199
55Broad thumb (HP:0011304)1.88941820
56Wrist flexion contracture (HP:0001239)1.88489131
57Genetic anticipation (HP:0003743)1.87920808
58Myelomeningocele (HP:0002475)1.87860877
59Impaired vibration sensation in the lower limbs (HP:0002166)1.87829976
60Mitral valve prolapse (HP:0001634)1.87644711
61Hallux valgus (HP:0001822)1.87134657
62Partial duplication of the phalanx of hand (HP:0009999)1.85413446
63Aplasia involving bones of the upper limbs (HP:0009823)1.84888249
64Aplasia of the phalanges of the hand (HP:0009802)1.84888249
65Aplasia involving bones of the extremities (HP:0009825)1.84888249
66Embryonal renal neoplasm (HP:0011794)1.84546794
67Astrocytoma (HP:0009592)1.82655482
68Abnormality of the astrocytes (HP:0100707)1.82655482
69Progressive cerebellar ataxia (HP:0002073)1.82444069
70Asymmetry of the thorax (HP:0001555)1.79172279
71Renal hypoplasia (HP:0000089)1.78539896
72Macroorchidism (HP:0000053)1.78049777
73Cutaneous finger syndactyly (HP:0010554)1.77726926
74Subacute progressive viral hepatitis (HP:0006572)1.76666540
75Lymphangioma (HP:0100764)1.76635750
76Increased nuchal translucency (HP:0010880)1.76583217
77Ependymoma (HP:0002888)1.75953324
78Coronal craniosynostosis (HP:0004440)1.75403877
79Broad long bones (HP:0005622)1.74384223
80Abnormality of the antihelix (HP:0009738)1.73886381
81Epileptic encephalopathy (HP:0200134)1.73602299
82Trigonocephaly (HP:0000243)1.72705974
83Abnormality of dentin (HP:0010299)1.71983086
84Broad finger (HP:0001500)1.71011608
85Broad phalanges of the hand (HP:0009768)1.70339607
86Volvulus (HP:0002580)1.70079167
87Abnormal number of incisors (HP:0011064)1.67781193
88Abnormality of oral frenula (HP:0000190)1.66876992
89Skull defect (HP:0001362)1.66609811
90Broad phalanx (HP:0006009)1.66574529
91Lower limb amyotrophy (HP:0007210)1.66425871
92Duplication of thumb phalanx (HP:0009942)1.66279475
93Turricephaly (HP:0000262)1.65852705
94Spastic diplegia (HP:0001264)1.65332091
95Aqueductal stenosis (HP:0002410)1.64768237
96Obsessive-compulsive behavior (HP:0000722)1.64689858
97Ankle clonus (HP:0011448)1.64447980
98Facial cleft (HP:0002006)1.64438852
99Generalized hypotonia (HP:0001290)1.64351441
100Megalencephaly (HP:0001355)1.64091908
101Bronchomalacia (HP:0002780)1.63339983
102Atonic seizures (HP:0010819)1.63282490
103Enlarged penis (HP:0000040)1.62952627
104Esophageal atresia (HP:0002032)1.62813533
105Urinary bladder sphincter dysfunction (HP:0002839)1.61838891
106Ectopic kidney (HP:0000086)1.61509664
107Amyotrophic lateral sclerosis (HP:0007354)1.61067145
108Shoulder girdle muscle weakness (HP:0003547)1.59796267
109Midline defect of the nose (HP:0004122)1.59766669
110Depression (HP:0000716)1.58959881
111Dysmetric saccades (HP:0000641)1.58442086
112Soft skin (HP:0000977)1.58120641
113Neoplasm of the oral cavity (HP:0100649)1.58066949
114Drooling (HP:0002307)1.57612333
115Morphological abnormality of the middle ear (HP:0008609)1.57508248
116Aortic aneurysm (HP:0004942)1.57091233
117Urinary urgency (HP:0000012)1.56370574
118Aortic dissection (HP:0002647)1.56085683
119Increased variability in muscle fiber diameter (HP:0003557)1.55567849
120Poor eye contact (HP:0000817)1.55118215
121Cutaneous syndactyly (HP:0012725)1.54784804
122Microglossia (HP:0000171)1.54626474
123Shawl scrotum (HP:0000049)1.54529836
124Rhabdomyosarcoma (HP:0002859)1.54192950
125Neoplasm of the heart (HP:0100544)1.53900827
126Gastrointestinal atresia (HP:0002589)1.53885737
127Abnormality of the calcaneus (HP:0008364)1.53035318
128Abnormality of the diencephalon (HP:0010662)1.52784909
129Omphalocele (HP:0001539)1.52695660
130Broad-based gait (HP:0002136)1.51812334
131Absent eyebrow (HP:0002223)1.51636974
132Upper limb amyotrophy (HP:0009129)1.51502739
133Distal upper limb amyotrophy (HP:0007149)1.51502739
134Chromosomal breakage induced by crosslinking agents (HP:0003221)1.51120868
135Bicornuate uterus (HP:0000813)1.50923949
136Broad ribs (HP:0000885)1.50635143
137Congenital glaucoma (HP:0001087)1.50620267
138Abnormality of abdominal situs (HP:0011620)1.50534946
139Abdominal situs inversus (HP:0003363)1.50534946
140Wide anterior fontanel (HP:0000260)1.50490510
141Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.50226410
142Absent epiphyses (HP:0010577)1.50226410
143Arnold-Chiari malformation (HP:0002308)1.49875206
144Absent radius (HP:0003974)1.49615073
145Hypoventilation (HP:0002791)1.49484505
146Hemiplegia (HP:0002301)1.49475129
147Resting tremor (HP:0002322)1.49401952
148Meckel diverticulum (HP:0002245)1.49300490
149Absent septum pellucidum (HP:0001331)1.48861407
150Optic nerve hypoplasia (HP:0000609)1.48375086
151Papilledema (HP:0001085)1.47897809
152Impaired social interactions (HP:0000735)1.47830246
153Abnormal social behavior (HP:0012433)1.47830246
154Medulloblastoma (HP:0002885)1.47510588
155Broad palm (HP:0001169)1.47377552
156Abnormality of the septum pellucidum (HP:0007375)1.46191750
157Hypoplastic pelvis (HP:0008839)1.45046504
158Chromsome breakage (HP:0040012)1.44969255
159Tracheomalacia (HP:0002779)1.43748670
160Micropenis (HP:0000054)1.43423286
161Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.43160522
162Abnormality of the ileum (HP:0001549)1.42151993
163Abnormality of the middle phalanges of the toes (HP:0010183)1.41950841
164Aplasia involving forearm bones (HP:0009822)1.41637991

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.18929909
2EPHA42.89967685
3NTRK32.89929365
4LATS22.64209371
5MAP3K92.57222829
6TNIK2.50567544
7MKNK12.44167258
8PRKD32.42717286
9MKNK22.38470637
10TTK2.35087509
11MAP3K42.18385815
12MINK12.17465878
13CASK2.16296481
14PDGFRA2.11893631
15PAK62.06809453
16DDR22.03440996
17SRPK11.97221377
18TRIB31.94249142
19BCR1.88382448
20KSR11.84005939
21WNK31.83612742
22RIPK11.77732834
23TSSK61.73122302
24PLK41.69599780
25BRD41.68523944
26NEK11.68435987
27CAMKK11.66196596
28BUB11.59529006
29DAPK21.54708487
30NTRK21.53917488
31TYRO31.53676821
32PKN21.52565692
33EPHB21.48173524
34KSR21.46759150
35SCYL21.46102532
36WEE11.45556954
37LATS11.42682180
38NTRK11.41783790
39TTN1.38652861
40PLK21.38203911
41STK381.38172880
42TAF11.33872099
43DYRK21.27151055
44PNCK1.24073032
45ALK1.24043292
46SIK21.22581777
47PAK31.20932979
48ICK1.20488010
49TIE11.19924807
50TRIM281.19528228
51ERBB31.14582168
52CSNK1G11.13020283
53PLK11.08552125
54DMPK1.04382795
55MAP2K41.03938834
56UHMK11.02625938
57CDK51.01259402
58FGFR11.00253228
59CDK150.97927066
60TAOK10.97870142
61CDK180.96596408
62CDK140.94871936
63CDC42BPA0.92693208
64CHEK20.92025071
65STK30.91608957
66MAPK130.90888548
67ATR0.90172178
68CDC70.88988879
69CAMK1G0.88801870
70FER0.88623229
71BRSK20.88139163
72MAP2K70.88055145
73RET0.88037260
74MAP3K100.87590261
75PHKG10.87399857
76PHKG20.87399857
77PAK20.86064321
78CSNK1A1L0.85404821
79PTK2B0.85377169
80CDK11A0.84117144
81FGFR20.84000967
82CSNK1G30.83120434
83DYRK30.82054334
84ATM0.80500528
85PTK20.79933633
86EEF2K0.79922246
87DAPK10.78431148
88LMTK20.78054240
89PRKCH0.76128730
90BMX0.75887781
91MTOR0.75234457
92PRKCG0.74041966
93CHEK10.73076586
94STK110.72738224
95CDK120.72431866
96ROCK10.71805989
97PBK0.68870335
98PLK30.67522121
99CDK10.65649685
100BRSK10.64247448
101PDGFRB0.64210714
102AURKB0.64049985
103WNK10.63713819
104PTK60.60232068
105VRK20.60113839
106ERBB20.59920554
107ZAK0.58800150
108CDK70.58716887
109LIMK10.57764262
110PASK0.56294311
111CDK20.56223649
112ILK0.56069500
113CDK30.55796582
114CDK190.55602161
115ERBB40.55340411
116DYRK1A0.54941590
117CSNK1G20.54272788
118MARK20.53269730
119CSNK1E0.52969250
120MAP3K20.52785452
121SGK4940.52098955
122SGK2230.52098955
123MAPK100.51199924
124SGK30.49298484
125PAK40.49140174
126RPS6KA30.47821248
127SGK10.47001074
128NUAK10.46579083
129ROCK20.45950617
130RPS6KA20.45293827
131NEK20.44441477
132SMG10.43232488
133MAPK80.42519401
134STK38L0.42488939
135AKT30.41326342
136CAMK10.41112944
137PRKDC0.41102068
138PRPF4B0.40981080
139CAMK2A0.40867162
140PDK30.40444731
141PDK40.40444731
142VRK10.40348879
143CLK10.40332945
144SGK20.40301580
145CAMK1D0.40101499
146GSK3B0.38949853
147TESK10.37557467
148MAPK90.37491285

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.20251584
2Long-term potentiation_Homo sapiens_hsa047202.08446024
3Circadian entrainment_Homo sapiens_hsa047132.05676857
4Non-homologous end-joining_Homo sapiens_hsa034502.03957620
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.98469330
6Synaptic vesicle cycle_Homo sapiens_hsa047211.98436390
7Olfactory transduction_Homo sapiens_hsa047401.94333015
8DNA replication_Homo sapiens_hsa030301.93151689
9Mismatch repair_Homo sapiens_hsa034301.91728612
10Steroid biosynthesis_Homo sapiens_hsa001001.91191248
11GABAergic synapse_Homo sapiens_hsa047271.84129903
12Amphetamine addiction_Homo sapiens_hsa050311.83344781
13Cell cycle_Homo sapiens_hsa041101.82843139
14Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.79125648
15Dopaminergic synapse_Homo sapiens_hsa047281.78602900
16Glutamatergic synapse_Homo sapiens_hsa047241.78554907
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.74149891
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.65524399
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.65512547
20Axon guidance_Homo sapiens_hsa043601.63465346
21Morphine addiction_Homo sapiens_hsa050321.63074400
22Gap junction_Homo sapiens_hsa045401.61953378
23Hippo signaling pathway_Homo sapiens_hsa043901.61527669
24Dilated cardiomyopathy_Homo sapiens_hsa054141.57607207
25RNA transport_Homo sapiens_hsa030131.55775426
26Oocyte meiosis_Homo sapiens_hsa041141.55109247
27Glioma_Homo sapiens_hsa052141.51930942
28Spliceosome_Homo sapiens_hsa030401.50652161
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.50595833
30Oxytocin signaling pathway_Homo sapiens_hsa049211.50581686
31Cholinergic synapse_Homo sapiens_hsa047251.49144829
32Hedgehog signaling pathway_Homo sapiens_hsa043401.47509338
33Basal cell carcinoma_Homo sapiens_hsa052171.47003958
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.46052970
35Salivary secretion_Homo sapiens_hsa049701.44124259
36Gastric acid secretion_Homo sapiens_hsa049711.43750695
37Melanogenesis_Homo sapiens_hsa049161.43700757
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.42250278
39Vitamin B6 metabolism_Homo sapiens_hsa007501.39862620
40Estrogen signaling pathway_Homo sapiens_hsa049151.38211570
41Long-term depression_Homo sapiens_hsa047301.37437820
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.37337087
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.37036903
44Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.36094504
45Cocaine addiction_Homo sapiens_hsa050301.35478507
46Insulin secretion_Homo sapiens_hsa049111.35469380
47GnRH signaling pathway_Homo sapiens_hsa049121.34602578
48Lysine degradation_Homo sapiens_hsa003101.34406395
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.32788919
50Renin secretion_Homo sapiens_hsa049241.32612228
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28816691
52Fanconi anemia pathway_Homo sapiens_hsa034601.28227746
53Cysteine and methionine metabolism_Homo sapiens_hsa002701.28098727
54Focal adhesion_Homo sapiens_hsa045101.22167357
55Selenocompound metabolism_Homo sapiens_hsa004501.20958446
56Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.20751067
57Wnt signaling pathway_Homo sapiens_hsa043101.20241180
58Biosynthesis of amino acids_Homo sapiens_hsa012301.19827286
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.19500590
60mTOR signaling pathway_Homo sapiens_hsa041501.19239272
61Endometrial cancer_Homo sapiens_hsa052131.18060987
62Proteoglycans in cancer_Homo sapiens_hsa052051.18019850
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16730959
64One carbon pool by folate_Homo sapiens_hsa006701.14553182
65Adherens junction_Homo sapiens_hsa045201.14216051
66Propanoate metabolism_Homo sapiens_hsa006401.13486371
67ErbB signaling pathway_Homo sapiens_hsa040121.12355249
68cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11903139
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11723346
70Type II diabetes mellitus_Homo sapiens_hsa049301.10629418
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.09952312
72Pyruvate metabolism_Homo sapiens_hsa006201.08212742
73Base excision repair_Homo sapiens_hsa034101.08162647
74cAMP signaling pathway_Homo sapiens_hsa040241.07185211
75Calcium signaling pathway_Homo sapiens_hsa040201.06550800
76* Tight junction_Homo sapiens_hsa045301.05855130
77Thyroid hormone signaling pathway_Homo sapiens_hsa049191.05753638
78Colorectal cancer_Homo sapiens_hsa052101.05207418
79Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.04852132
80Taste transduction_Homo sapiens_hsa047421.04160231
81Homologous recombination_Homo sapiens_hsa034401.03988974
82ECM-receptor interaction_Homo sapiens_hsa045121.01657017
83Basal transcription factors_Homo sapiens_hsa030221.00833388
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00496573
85Rap1 signaling pathway_Homo sapiens_hsa040150.97612346
86Nucleotide excision repair_Homo sapiens_hsa034200.93152302
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.92938403
88Dorso-ventral axis formation_Homo sapiens_hsa043200.92307292
89MicroRNAs in cancer_Homo sapiens_hsa052060.92231450
90Serotonergic synapse_Homo sapiens_hsa047260.90596794
91RNA degradation_Homo sapiens_hsa030180.90547642
92Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88942002
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88884185
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.87186249
95Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86985031
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86983515
97Alcoholism_Homo sapiens_hsa050340.85994633
98TGF-beta signaling pathway_Homo sapiens_hsa043500.84855981
99Thyroid cancer_Homo sapiens_hsa052160.84296782
100Renal cell carcinoma_Homo sapiens_hsa052110.83783983
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83147192
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.83112205
103Non-small cell lung cancer_Homo sapiens_hsa052230.82954940
104Protein export_Homo sapiens_hsa030600.82345470
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.82092768
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81422691
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81092219
108mRNA surveillance pathway_Homo sapiens_hsa030150.78929898
109Chronic myeloid leukemia_Homo sapiens_hsa052200.78880212
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78767815
111Bladder cancer_Homo sapiens_hsa052190.78320650
112MAPK signaling pathway_Homo sapiens_hsa040100.78188347
113Cardiac muscle contraction_Homo sapiens_hsa042600.77473038
114Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77296577
115Thyroid hormone synthesis_Homo sapiens_hsa049180.77090236
116VEGF signaling pathway_Homo sapiens_hsa043700.76215462
117Fatty acid metabolism_Homo sapiens_hsa012120.75734737
118Carbon metabolism_Homo sapiens_hsa012000.75527640
119Glucagon signaling pathway_Homo sapiens_hsa049220.75070023
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73415074
121RNA polymerase_Homo sapiens_hsa030200.72659345
122Melanoma_Homo sapiens_hsa052180.69456245
123Insulin signaling pathway_Homo sapiens_hsa049100.69221444
124Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69035766
125* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68452368
126Amoebiasis_Homo sapiens_hsa051460.68349782
127Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67664555
128Choline metabolism in cancer_Homo sapiens_hsa052310.66510382
129AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62905628
130Endocytosis_Homo sapiens_hsa041440.62038526
131Ras signaling pathway_Homo sapiens_hsa040140.59284831
132Arginine and proline metabolism_Homo sapiens_hsa003300.58338436
133Pathways in cancer_Homo sapiens_hsa052000.58324541
134Notch signaling pathway_Homo sapiens_hsa043300.57195284
135Prostate cancer_Homo sapiens_hsa052150.57095306
136Protein digestion and absorption_Homo sapiens_hsa049740.53957712
137AMPK signaling pathway_Homo sapiens_hsa041520.53820261
138Fatty acid elongation_Homo sapiens_hsa000620.53226097
139Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52787492
140PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48779428
141Small cell lung cancer_Homo sapiens_hsa052220.47559677
142Viral myocarditis_Homo sapiens_hsa054160.47173661
143Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46785382
144Platelet activation_Homo sapiens_hsa046110.46455837
145p53 signaling pathway_Homo sapiens_hsa041150.44435576
146Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43235906
147Butanoate metabolism_Homo sapiens_hsa006500.43195063
148Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40582391
149Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40423511
150Purine metabolism_Homo sapiens_hsa002300.39766933

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