MYCT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1definitive hemopoiesis (GO:0060216)9.35959320
2ribosomal small subunit assembly (GO:0000028)8.70041459
3lymphangiogenesis (GO:0001946)6.82503072
4platelet dense granule organization (GO:0060155)6.16460688
5thrombin receptor signaling pathway (GO:0070493)6.01734534
6megakaryocyte development (GO:0035855)5.94728422
7viral transcription (GO:0019083)5.89117382
8regulation of endothelial cell differentiation (GO:0045601)5.68345242
9translational termination (GO:0006415)5.61725745
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.52271459
11mature B cell differentiation involved in immune response (GO:0002313)5.42120366
12positive regulation of endothelial cell differentiation (GO:0045603)5.37741626
13negative regulation of erythrocyte differentiation (GO:0045647)5.34707639
14negative regulation of blood vessel endothelial cell migration (GO:0043537)5.31392942
15antigen processing and presentation via MHC class Ib (GO:0002475)5.29105301
16regulation of vasculogenesis (GO:2001212)5.25951550
17response to interferon-beta (GO:0035456)4.97575748
18maturation of SSU-rRNA (GO:0030490)4.93575672
19ribosomal small subunit biogenesis (GO:0042274)4.91118739
20endoderm formation (GO:0001706)4.81445614
21translational elongation (GO:0006414)4.79505638
22sprouting angiogenesis (GO:0002040)4.78054179
23aggressive behavior (GO:0002118)4.77667446
24SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.76055206
25cotranslational protein targeting to membrane (GO:0006613)4.64963643
26retina vasculature morphogenesis in camera-type eye (GO:0061299)4.64517663
27protein targeting to ER (GO:0045047)4.62114478
28lymph node development (GO:0048535)4.57322947
29antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.49635342
30antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.49635342
31establishment of protein localization to endoplasmic reticulum (GO:0072599)4.40002487
32protein localization to endoplasmic reticulum (GO:0070972)4.37369117
33nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.31222622
34embryonic heart tube development (GO:0035050)4.30867077
35response to interferon-alpha (GO:0035455)4.21402042
36viral life cycle (GO:0019058)4.21155540
37endosome to pigment granule transport (GO:0043485)4.21144436
38endosome to melanosome transport (GO:0035646)4.21144436
39negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)4.15284496
40wound healing, spreading of epidermal cells (GO:0035313)4.13455131
41L-fucose catabolic process (GO:0042355)4.13350170
42fucose catabolic process (GO:0019317)4.13350170
43L-fucose metabolic process (GO:0042354)4.13350170
44secretory granule organization (GO:0033363)4.11759524
45blood vessel maturation (GO:0001955)4.08222944
46negative regulation of T-helper cell differentiation (GO:0045623)4.03666637
47negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.03666637
48regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.97016939
49vascular endothelial growth factor signaling pathway (GO:0038084)3.95869241
50cellular protein complex disassembly (GO:0043624)3.95570639
51mature B cell differentiation (GO:0002335)3.94561163
52interkinetic nuclear migration (GO:0022027)3.92036881
53lymphoid progenitor cell differentiation (GO:0002320)3.90361574
54endothelial cell differentiation (GO:0045446)3.90339402
55positive regulation of urine volume (GO:0035810)3.87475476
56embryonic hemopoiesis (GO:0035162)3.87234778
57Rap protein signal transduction (GO:0032486)3.80357473
58endothelial cell proliferation (GO:0001935)3.79717880
59positive regulation of interleukin-8 secretion (GO:2000484)3.76351657
60negative regulation of endothelial cell migration (GO:0010596)3.74993040
61angiogenesis involved in wound healing (GO:0060055)3.72569998
62Peyers patch development (GO:0048541)3.70047066
63mucosal-associated lymphoid tissue development (GO:0048537)3.70047066
64cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.69457184
65positive regulation of gamma-delta T cell activation (GO:0046645)3.64294039
66endothelium development (GO:0003158)3.60288904
67organ formation (GO:0048645)3.58559517
68translational initiation (GO:0006413)3.57064041
69antigen processing and presentation of endogenous antigen (GO:0019883)3.55649924
70protein complex disassembly (GO:0043241)3.48971868
71Notch signaling involved in heart development (GO:0061314)3.48886670
72negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.46133292
73positive regulation of B cell differentiation (GO:0045579)3.45461864
74heparin biosynthetic process (GO:0030210)3.45033082
75heparin metabolic process (GO:0030202)3.45033082
76regulation of mesoderm development (GO:2000380)3.45020447
77regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)3.44058512
78positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.44048719
79heart trabecula morphogenesis (GO:0061384)3.43356025
80artery development (GO:0060840)3.42928106
81negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.41776870
82regulation of blood vessel endothelial cell migration (GO:0043535)3.41641678
83T cell homeostasis (GO:0043029)3.40948690
84positive regulation of respiratory burst (GO:0060267)3.38250002
85negative regulation of platelet activation (GO:0010544)3.37803522
86regulation of integrin-mediated signaling pathway (GO:2001044)3.37029046
87nuclear-transcribed mRNA catabolic process (GO:0000956)3.33745040
88regulation of erythrocyte differentiation (GO:0045646)3.31065769
89ventricular trabecula myocardium morphogenesis (GO:0003222)3.30364443
90negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.29865899
91glomerular filtration (GO:0003094)3.29777581
92negative regulation of viral entry into host cell (GO:0046597)3.29275058
93regulation of urine volume (GO:0035809)3.25875095
94lymph vessel development (GO:0001945)3.24963548
95positive regulation of vasculogenesis (GO:2001214)3.23586079
96purine-containing compound salvage (GO:0043101)3.23495231
97mRNA catabolic process (GO:0006402)3.22996946
98macromolecular complex disassembly (GO:0032984)3.22037575
99positive regulation of odontogenesis (GO:0042482)3.21268865
100mRNA transcription from RNA polymerase II promoter (GO:0042789)3.16774671
101polyketide metabolic process (GO:0030638)3.15221609
102doxorubicin metabolic process (GO:0044598)3.15221609
103daunorubicin metabolic process (GO:0044597)3.15221609
104phospholipid scrambling (GO:0017121)3.13859287
105establishment of endothelial barrier (GO:0061028)3.12711267
106regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.12316721
107response to protozoan (GO:0001562)3.08639665
108protein targeting to membrane (GO:0006612)3.08035791
109negative regulation of nitric oxide biosynthetic process (GO:0045019)3.07788002
110response to type I interferon (GO:0034340)3.03463484
111transcytosis (GO:0045056)3.03423571
112defense response to protozoan (GO:0042832)3.03321336
113regulation of platelet activation (GO:0010543)3.01707201
114trabecula morphogenesis (GO:0061383)3.00789681
115tyrosine phosphorylation of STAT protein (GO:0007260)3.00169035
116cellular response to thyroid hormone stimulus (GO:0097067)2.99997500
117ether lipid metabolic process (GO:0046485)2.99274008
118respiratory chain complex IV assembly (GO:0008535)2.99194112
119sequestering of extracellular ligand from receptor (GO:0035581)2.98999176
120angiogenesis (GO:0001525)2.98197079
121blood coagulation, intrinsic pathway (GO:0007597)2.97730868
122phagocytosis, engulfment (GO:0006911)2.96815628
123negative regulation of protein localization to cell surface (GO:2000009)2.96182856
124regulation of gamma-delta T cell differentiation (GO:0045586)2.95110094
125regulation of endothelial cell migration (GO:0010594)2.94528505
126RNA catabolic process (GO:0006401)2.94276366
127cellular response to type I interferon (GO:0071357)2.93160001
128type I interferon signaling pathway (GO:0060337)2.93160001
129patterning of blood vessels (GO:0001569)2.92854127
130histamine secretion (GO:0001821)2.92283945
131necroptotic process (GO:0070266)2.91091565
132negative regulation of viral genome replication (GO:0045071)2.90633426
133negative regulation of stress fiber assembly (GO:0051497)2.90263808
134plasma membrane fusion (GO:0045026)2.89497825
135cGMP biosynthetic process (GO:0006182)2.88970412
136cellular response to BMP stimulus (GO:0071773)2.87480901
137response to BMP (GO:0071772)2.87480901
138negative regulation of angiogenesis (GO:0016525)2.87296175
139DNA deamination (GO:0045006)2.87194801
140L-ascorbic acid metabolic process (GO:0019852)2.86708297
141vasculogenesis (GO:0001570)2.85284598
142facial nerve structural organization (GO:0021612)2.84990737
143negative regulation of transcription by competitive promoter binding (GO:0010944)2.84579818
144positive regulation of T cell mediated cytotoxicity (GO:0001916)2.84508933
145cell migration involved in gastrulation (GO:0042074)2.84487829
146negative regulation of cell junction assembly (GO:1901889)2.83829456
147negative regulation of adherens junction organization (GO:1903392)2.83829456
148negative regulation of focal adhesion assembly (GO:0051895)2.83829456
149negative regulation of activin receptor signaling pathway (GO:0032926)2.83158333
150leukocyte homeostasis (GO:0001776)2.83069899
151positive regulation of granulocyte differentiation (GO:0030854)2.82757258
152negative regulation of actin filament bundle assembly (GO:0032232)2.82365949
153endothelial tube morphogenesis (GO:0061154)2.78153053
154morphogenesis of an endothelium (GO:0003159)2.78153053
155heart valve formation (GO:0003188)2.77359320
156negative regulation of blood vessel morphogenesis (GO:2000181)2.77149897
157energy homeostasis (GO:0097009)2.76111309
158regulation of T cell mediated cytotoxicity (GO:0001914)2.75886820
159regulation of establishment or maintenance of cell polarity (GO:0032878)2.74946810
160positive regulation of focal adhesion assembly (GO:0051894)2.74891839
161positive regulation of cell junction assembly (GO:1901890)2.74891839
162renal filtration (GO:0097205)2.73859950
163positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.73111314
164myeloid cell development (GO:0061515)2.72552095
165negative regulation of nitric-oxide synthase activity (GO:0051001)2.72507460
166regulation of necroptotic process (GO:0060544)2.71285461
167regulation of natural killer cell differentiation (GO:0032823)2.71012952
168mRNA transcription (GO:0009299)2.69966659
169cytokine production involved in immune response (GO:0002367)2.69582876
170vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.69347481
171regulation of regulatory T cell differentiation (GO:0045589)2.68973167
172CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.68820992
173regulation of gamma-delta T cell activation (GO:0046643)2.68246357
174heart contraction (GO:0060047)2.68110957
175heart process (GO:0003015)2.68110957
176positive regulation of glomerulus development (GO:0090193)2.67902600
177production of molecular mediator involved in inflammatory response (GO:0002532)2.67897071
178epithelial cell differentiation involved in kidney development (GO:0035850)2.67120187
179negative regulation of vasculature development (GO:1901343)2.67030658
180regulation of lipoprotein metabolic process (GO:0050746)2.66344323
181leukocyte tethering or rolling (GO:0050901)2.64956239
182substrate adhesion-dependent cell spreading (GO:0034446)2.64235611
183protein neddylation (GO:0045116)2.62005816
184primitive streak formation (GO:0090009)2.60088686
185positive regulation of endothelial cell migration (GO:0010595)2.59921004
186negative regulation of epithelial cell migration (GO:0010633)2.58524486

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_19346495_ChIP-Seq_HPC-7_Human6.54590060
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.90138317
3RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.73375483
4* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.67329735
5GATA1_22025678_ChIP-Seq_K562_Human3.56425608
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.44079746
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.31824205
8LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.25148121
9TAL1_20887958_ChIP-Seq_HPC-7_Mouse3.15782405
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.12856704
11SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse3.09762279
12NOTCH1_21737748_ChIP-Seq_TLL_Human3.00785801
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.97309621
14* GATA2_21666600_ChIP-Seq_HMVEC_Human2.79481689
15VDR_22108803_ChIP-Seq_LS180_Human2.75528030
16FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.73616536
17CDX2_19796622_ChIP-Seq_MESCs_Mouse2.71294850
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.62162436
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.58653127
20LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.52599239
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.52166889
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.51922162
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.51211847
24* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.46264805
25MYC_18555785_ChIP-Seq_MESCs_Mouse2.42583345
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.39836404
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.26596015
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.25399761
29SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.23062868
30* HOXB4_20404135_ChIP-ChIP_EML_Mouse2.22764177
31GATA2_20887958_ChIP-Seq_HPC-7_Mouse2.20200434
32SPI1_23547873_ChIP-Seq_NB4_Human2.18436574
33MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.17056435
34ERG_20887958_ChIP-Seq_HPC-7_Mouse2.12704141
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.12325616
36SMAD_19615063_ChIP-ChIP_OVARY_Human2.10438959
37NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.01953214
38NRF2_20460467_ChIP-Seq_MEFs_Mouse2.01953214
39GATA1_22383799_ChIP-Seq_G1ME_Mouse1.95511972
40CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.92991391
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.90123980
42P300_19829295_ChIP-Seq_ESCs_Human1.89943064
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.88692851
44RUNX_20019798_ChIP-Seq_JUKART_Human1.88113633
45SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.87856763
46FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.87541368
47SALL4_18804426_ChIP-ChIP_XEN_Mouse1.86114525
48SMAD3_21741376_ChIP-Seq_HESCs_Human1.84374560
49MYC_22102868_ChIP-Seq_BL_Human1.78311391
50* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.78030527
51* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.77875345
52WT1_19549856_ChIP-ChIP_CCG9911_Human1.77272850
53* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.74751868
54VDR_21846776_ChIP-Seq_THP-1_Human1.73587559
55TCF7_22412390_ChIP-Seq_EML_Mouse1.73281660
56GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.70452263
57FUS_26573619_Chip-Seq_HEK293_Human1.68874751
58EWS_26573619_Chip-Seq_HEK293_Human1.67783820
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.67734100
60E2F7_22180533_ChIP-Seq_HELA_Human1.66409599
61SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64063145
62TAF15_26573619_Chip-Seq_HEK293_Human1.61712845
63EP300_21415370_ChIP-Seq_HL-1_Mouse1.60945136
64FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.60897677
65TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.60855890
66MYB_26560356_Chip-Seq_TH2_Human1.59348543
67HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.59339088
68NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.58303520
69SMAD4_21741376_ChIP-Seq_HESCs_Human1.57888757
70MAF_26560356_Chip-Seq_TH1_Human1.57528208
71GATA1_19941827_ChIP-Seq_MEL_Mouse1.57239037
72PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.57093770
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.54590732
74VDR_24763502_ChIP-Seq_THP-1_Human1.54433490
75NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53507638
76BCAT_22108803_ChIP-Seq_LS180_Human1.53355103
77CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.53354537
78MYB_26560356_Chip-Seq_TH1_Human1.52760096
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.48854554
80PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.47756662
81* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47422910
82* SMAD3_21741376_ChIP-Seq_EPCs_Human1.45857908
83SOX2_19829295_ChIP-Seq_ESCs_Human1.41795509
84NANOG_19829295_ChIP-Seq_ESCs_Human1.41795509
85EGR1_19374776_ChIP-ChIP_THP-1_Human1.41548586
86KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.41260499
87KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.41260499
88KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.41260499
89RBPJ_22232070_ChIP-Seq_NCS_Mouse1.40741759
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40229526
91EST1_17652178_ChIP-ChIP_JURKAT_Human1.39367387
92FOXP3_21729870_ChIP-Seq_TREG_Human1.38918105
93FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37979417
94GATA1_19941826_ChIP-Seq_K562_Human1.36980015
95CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.36513140
96VDR_23849224_ChIP-Seq_CD4+_Human1.33588762
97ELK3_25401928_ChIP-Seq_HUVEC_Human1.32750084
98EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32515342
99STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.31899448
100CDX2_22108803_ChIP-Seq_LS180_Human1.31883120
101SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30622571
102MYC_18358816_ChIP-ChIP_MESCs_Mouse1.30594826
103TRIM28_21343339_ChIP-Seq_HEK293_Human1.29467322
104CJUN_26792858_Chip-Seq_BT549_Human1.29430162
105KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.29114307
106* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28874855
107FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27765003
108UTX_26944678_Chip-Seq_JUKART_Human1.26865254
109FOXA1_21572438_ChIP-Seq_LNCaP_Human1.26808242
110* EZH2_27294783_Chip-Seq_NPCs_Mouse1.26716874
111ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.25341882
112Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.25294089
113SPI1_23127762_ChIP-Seq_K562_Human1.24222965
114IGF1R_20145208_ChIP-Seq_DFB_Human1.22894683
115PIAS1_25552417_ChIP-Seq_VCAP_Human1.22638932
116* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.22325291
117ZNF274_21170338_ChIP-Seq_K562_Hela1.21396915
118PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21124428
119KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.17913443
120ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17614388
121ETS1_22383799_ChIP-Seq_G1ME_Mouse1.17464749
122NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.16778356
123FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16243904
124IRF8_21731497_ChIP-ChIP_J774_Mouse1.15598640
125SMAD4_21799915_ChIP-Seq_A2780_Human1.15349570
126TP63_19390658_ChIP-ChIP_HaCaT_Human1.14881974
127* SMAD4_21741376_ChIP-Seq_EPCs_Human1.14752005
128* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14132512
129MYC_19030024_ChIP-ChIP_MESCs_Mouse1.13877067
130IRF8_27001747_Chip-Seq_BMDM_Mouse1.13332639
131ELK1_19687146_ChIP-ChIP_HELA_Human1.12965139
132MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12439177
133BRD4_27068464_Chip-Seq_AML-cells_Mouse1.10893763
134RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10602799
135UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10158017
136TCF4_22108803_ChIP-Seq_LS180_Human1.09620687
137XRN2_22483619_ChIP-Seq_HELA_Human1.07309905
138SOX2_20726797_ChIP-Seq_SW620_Human1.07294609
139GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.06540857
140BRD4_25478319_ChIP-Seq_HGPS_Human1.05989539
141* FLI1_21867929_ChIP-Seq_TH2_Mouse1.03547297
142HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.03461214
143E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.03046029
144CBP_20019798_ChIP-Seq_JUKART_Human1.02209003
145IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02209003
146GATA2_19941826_ChIP-Seq_K562_Human1.01698604
147AR_25329375_ChIP-Seq_VCAP_Human1.01629729
148EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00927380
149SALL4_22934838_ChIP-ChIP_CD34+_Human1.00208496
150GABP_17652178_ChIP-ChIP_JURKAT_Human0.99246297
151MYC_19079543_ChIP-ChIP_MESCs_Mouse0.98576974
152TP63_23658742_ChIP-Seq_EP156T_Human0.97556756
153AR_20517297_ChIP-Seq_VCAP_Human0.97371598
154PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96960117
155NCOR1_26117541_ChIP-Seq_K562_Human0.96855553
156ER_23166858_ChIP-Seq_MCF-7_Human0.96816198
157TCF4_18268006_ChIP-ChIP_LS174T_Human0.96773579
158NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96671920
159CIITA_25753668_ChIP-Seq_RAJI_Human0.96125657
160E2F1_18555785_ChIP-Seq_MESCs_Mouse0.95327982
161* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.95304561
162EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94620836
163RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.94321162
164MAF_26560356_Chip-Seq_TH2_Human0.94134537
165* CRX_20693478_ChIP-Seq_RETINA_Mouse0.93926714
166GBX2_23144817_ChIP-Seq_PC3_Human0.92957177
167GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.92551294
168RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.92391881
169PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91768457
170TTF2_22483619_ChIP-Seq_HELA_Human0.91533657
171RUNX2_22187159_ChIP-Seq_PCA_Human0.91251324
172* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.90634766
173ETS1_20019798_ChIP-Seq_JURKAT_Human0.90436954
174STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90201923
175LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90164392
176HTT_18923047_ChIP-ChIP_STHdh_Human0.89442629
177PU_27001747_Chip-Seq_BMDM_Mouse0.87872193
178ZNF263_19887448_ChIP-Seq_K562_Human0.85477682
179ZFX_18555785_ChIP-Seq_MESCs_Mouse0.85029706
180GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84007850
181IRF1_19129219_ChIP-ChIP_H3396_Human0.83160419
182CTCF_21964334_ChIP-Seq_BJAB-B_Human0.81422507
183RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.80747640
184JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.80733890

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system4.33224679
2MP0008004_abnormal_stomach_pH3.71349173
3MP0002396_abnormal_hematopoietic_system3.58206305
4MP0004808_abnormal_hematopoietic_stem3.45736511
5MP0001879_abnormal_lymphatic_vessel3.31671571
6MP0003724_increased_susceptibility_to3.26100893
7MP0004272_abnormal_basement_membrane3.23035644
8MP0004147_increased_porphyrin_level3.19375027
9MP0001545_abnormal_hematopoietic_system3.04303013
10MP0005397_hematopoietic_system_phenotyp3.04303013
11MP0009379_abnormal_foot_pigmentation3.03496375
12MP0000465_gastrointestinal_hemorrhage2.77874709
13MP0005464_abnormal_platelet_physiology2.73937164
14MP0002138_abnormal_hepatobiliary_system2.72256370
15MP0003303_peritoneal_inflammation2.61286167
16MP0006054_spinal_hemorrhage2.57266040
17MP0009278_abnormal_bone_marrow2.50071562
18MP0001835_abnormal_antigen_presentation2.45483282
19MP0009785_altered_susceptibility_to2.29529420
20MP0005167_abnormal_blood-brain_barrier2.26511815
21MP0005174_abnormal_tail_pigmentation2.19337299
22MP0005075_abnormal_melanosome_morpholog2.17273944
23MP0003828_pulmonary_edema2.04634345
24MP0000685_abnormal_immune_system2.00162510
25MP0005671_abnormal_response_to1.99869201
26MP0009697_abnormal_copulation1.97088694
27MP0003890_abnormal_embryonic-extraembry1.94598346
28MP0003943_abnormal_hepatobiliary_system1.85737035
29MP0002095_abnormal_skin_pigmentation1.76066372
30MP0005025_abnormal_response_to1.71688653
31MP0001853_heart_inflammation1.71517608
32MP0003763_abnormal_thymus_physiology1.69904774
33MP0005595_abnormal_vascular_smooth1.65923525
34MP0002398_abnormal_bone_marrow1.65325484
35MP0002166_altered_tumor_susceptibility1.59364407
36MP0003191_abnormal_cellular_cholesterol1.58400197
37MP0000490_abnormal_crypts_of1.57983227
38MP0001873_stomach_inflammation1.56058116
39MP0001188_hyperpigmentation1.55620350
40MP0004084_abnormal_cardiac_muscle1.51911561
41MP0003866_abnormal_defecation1.46535478
42MP0000689_abnormal_spleen_morphology1.46166326
43MP0005409_darkened_coat_color1.45956728
44MP0002148_abnormal_hypersensitivity_rea1.43831930
45MP0002127_abnormal_cardiovascular_syste1.43695180
46MP0010155_abnormal_intestine_physiology1.42263150
47MP0002420_abnormal_adaptive_immunity1.41318618
48MP0001819_abnormal_immune_cell1.38274797
49MP0001800_abnormal_humoral_immune1.37157518
50MP0002452_abnormal_antigen_presenting1.36547299
51MP0002722_abnormal_immune_system1.36215002
52MP0003566_abnormal_cell_adhesion1.34245217
53MP0002723_abnormal_immune_serum1.33548916
54MP0003279_aneurysm1.32236622
55MP0008007_abnormal_cellular_replicative1.31266209
56MP0002429_abnormal_blood_cell1.30511732
57MP0000230_abnormal_systemic_arterial1.30446502
58MP0005084_abnormal_gallbladder_morpholo1.30127943
59MP0000716_abnormal_immune_system1.29850308
60MP0002925_abnormal_cardiovascular_devel1.28560310
61MP0003868_abnormal_feces_composition1.21490329
62MP0003567_abnormal_fetal_cardiomyocyte1.18926781
63MP0000343_altered_response_to1.17970690
64MP0002419_abnormal_innate_immunity1.17095275
65MP0004510_myositis1.17045999
66MP0001986_abnormal_taste_sensitivity1.16597741
67MP0000013_abnormal_adipose_tissue1.15918621
68MP0008775_abnormal_heart_ventricle1.15357422
69MP0002295_abnormal_pulmonary_circulatio1.14040925
70MP0004085_abnormal_heartbeat1.12527284
71MP0008995_early_reproductive_senescence1.11889114
72MP0005000_abnormal_immune_tolerance1.09600842
73MP0002972_abnormal_cardiac_muscle1.07591343
74MP0002132_abnormal_respiratory_system1.06781382
75MP0005670_abnormal_white_adipose1.03753871
76MP0000767_abnormal_smooth_muscle1.02301686
77MP0003436_decreased_susceptibility_to1.00946206
78MP0002128_abnormal_blood_circulation0.99444938
79MP0001784_abnormal_fluid_regulation0.97675537
80MP0006292_abnormal_olfactory_placode0.96509612
81MP0000703_abnormal_thymus_morphology0.96421153
82MP0006036_abnormal_mitochondrial_physio0.94099273
83MP0004036_abnormal_muscle_relaxation0.93219927
84MP0003638_abnormal_response/metabolism_0.92925623
85MP0001790_abnormal_immune_system0.92909297
86MP0005387_immune_system_phenotype0.92909297
87MP0000249_abnormal_blood_vessel0.92387508
88MP0005330_cardiomyopathy0.91923168
89MP0002234_abnormal_pharynx_morphology0.91754428
90MP0005646_abnormal_pituitary_gland0.91367633
91MP0002332_abnormal_exercise_endurance0.91087408
92MP0008469_abnormal_protein_level0.90991924
93MP0002006_tumorigenesis0.89918249
94MP0000516_abnormal_urinary_system0.89838951
95MP0005367_renal/urinary_system_phenotyp0.89838951
96MP0010630_abnormal_cardiac_muscle0.88354976
97MP0005385_cardiovascular_system_phenoty0.88025966
98MP0001544_abnormal_cardiovascular_syste0.88025966
99MP0002736_abnormal_nociception_after0.87197569
100MP0005620_abnormal_muscle_contractility0.84760833
101MP0003186_abnormal_redox_activity0.84738704
102MP0005165_increased_susceptibility_to0.84285306
103MP0000681_abnormal_thyroid_gland0.84016798
104MP0002877_abnormal_melanocyte_morpholog0.83816362
105MP0001845_abnormal_inflammatory_respons0.83785081
106MP0003950_abnormal_plasma_membrane0.81568552
107MP0002405_respiratory_system_inflammati0.81197869
108MP0005623_abnormal_meninges_morphology0.80129494
109MP0003011_delayed_dark_adaptation0.79836718
110MP0000266_abnormal_heart_morphology0.78942251
111MP0000015_abnormal_ear_pigmentation0.78930960
112MP0006276_abnormal_autonomic_nervous0.78840432
113MP0006138_congestive_heart_failure0.78835489
114MP0003195_calcinosis0.78415862
115MP0004484_altered_response_of0.77611630
116MP0003718_maternal_effect0.77549815
117MP0004145_abnormal_muscle_electrophysio0.77532643
118MP0009333_abnormal_splenocyte_physiolog0.75832380
119MP0002086_abnormal_extraembryonic_tissu0.75155992
120MP0005410_abnormal_fertilization0.75138914
121MP0001614_abnormal_blood_vessel0.73308129
122MP0009764_decreased_sensitivity_to0.73153411
123MP0005187_abnormal_penis_morphology0.72890007
124MP0008058_abnormal_DNA_repair0.72650668
125MP0009763_increased_sensitivity_to0.72465470
126MP0001851_eye_inflammation0.72256611
127MP0000598_abnormal_liver_morphology0.72206739
128MP0008875_abnormal_xenobiotic_pharmacok0.71618386
129MP0004782_abnormal_surfactant_physiolog0.71003707
130MP0002938_white_spotting0.70407772
131MP0002933_joint_inflammation0.68601602
132MP0001915_intracranial_hemorrhage0.67456923
133MP0002102_abnormal_ear_morphology0.66087851
134MP0002019_abnormal_tumor_incidence0.66013509
135MP0003119_abnormal_digestive_system0.64869721
136MP0003984_embryonic_growth_retardation0.64520111
137MP0001764_abnormal_homeostasis0.63048576
138MP0004215_abnormal_myocardial_fiber0.62420949
139MP0001664_abnormal_digestion0.62338802
140MP0002088_abnormal_embryonic_growth/wei0.60959675
141MP0003300_gastrointestinal_ulcer0.60784254
142MP0000749_muscle_degeneration0.60360692
143MP0001663_abnormal_digestive_system0.59700638
144MP0001293_anophthalmia0.58946577
145MP0005380_embryogenesis_phenotype0.51192585
146MP0001672_abnormal_embryogenesis/_devel0.51192585
147MP0001191_abnormal_skin_condition0.50451546
148MP0005023_abnormal_wound_healing0.49429275
149MP0008872_abnormal_physiological_respon0.48706814
150MP0005395_other_phenotype0.47859206
151MP0005365_abnormal_bile_salt0.47610310
152MP0009765_abnormal_xenobiotic_induced0.42262902
153MP0004885_abnormal_endolymph0.40162866
154MP0005275_abnormal_skin_tensile0.37973543

Predicted human phenotypes

RankGene SetZ-score
1Decreased central vision (HP:0007663)5.72709767
2Thrombocytosis (HP:0001894)5.70725235
3Prolonged bleeding time (HP:0003010)5.41299897
4Aplastic anemia (HP:0001915)5.39042704
5Abnormality of cells of the erythroid lineage (HP:0012130)5.19820253
6Abnormal number of erythroid precursors (HP:0012131)5.13850706
7Abnormality of the heme biosynthetic pathway (HP:0010472)4.10756150
8Epistaxis (HP:0000421)4.03937632
9Pancreatic islet-cell hyperplasia (HP:0004510)3.94551301
10Cerebral hemorrhage (HP:0001342)3.93497655
11Spontaneous hematomas (HP:0007420)3.90536701
12Cone-rod dystrophy (HP:0000548)3.81946312
13Petechiae (HP:0000967)3.76955312
14Conjunctival telangiectasia (HP:0000524)3.73558130
15Dynein arm defect of respiratory motile cilia (HP:0012255)3.58611003
16Absent/shortened dynein arms (HP:0200106)3.58611003
17Reticulocytopenia (HP:0001896)3.58128607
18Type 2 muscle fiber atrophy (HP:0003554)3.54747765
19Abnormal platelet function (HP:0011869)3.45367890
20Impaired platelet aggregation (HP:0003540)3.45367890
21Abnormality of the vasculature of the conjunctiva (HP:0008054)3.42628890
22Esophageal varix (HP:0002040)3.41725908
23Abnormality of the nasal mucosa (HP:0000433)3.39406689
24Chronic otitis media (HP:0000389)3.38824921
25Muscle fiber atrophy (HP:0100295)3.38351075
26Hypoglycemic seizures (HP:0002173)3.27926954
27Myositis (HP:0100614)3.26612992
28Gonadal dysgenesis (HP:0000133)3.26541310
29IgM deficiency (HP:0002850)3.25797635
30Abnormal delayed hypersensitivity skin test (HP:0002963)3.18995108
31Dyschromatopsia (HP:0007641)3.15441972
32Nonprogressive disorder (HP:0003680)3.14785697
33Weak cry (HP:0001612)3.09132650
34Elevated erythrocyte sedimentation rate (HP:0003565)3.09079968
35Microcytic anemia (HP:0001935)3.07789792
36Lymphangioma (HP:0100764)2.94345624
37Tetraparesis (HP:0002273)2.93042051
38Pallor (HP:0000980)2.91334754
39Gingival bleeding (HP:0000225)2.90232565
40Purpura (HP:0000979)2.89804596
41Acute myeloid leukemia (HP:0004808)2.88999844
42Delayed CNS myelination (HP:0002188)2.88356753
43Scotoma (HP:0000575)2.86782238
44Decreased electroretinogram (ERG) amplitude (HP:0000654)2.84990875
45Abnormal respiratory motile cilium morphology (HP:0005938)2.83822745
46Abnormal respiratory epithelium morphology (HP:0012253)2.83822745
47Hematochezia (HP:0002573)2.80766491
48Myelodysplasia (HP:0002863)2.78240394
49Asplenia (HP:0001746)2.77061997
50Abnormality of T cell physiology (HP:0011840)2.76117866
51Amaurosis fugax (HP:0100576)2.75861939
52Abnormality of macular pigmentation (HP:0008002)2.74846085
53Abnormal ciliary motility (HP:0012262)2.72079912
54Reduced antithrombin III activity (HP:0001976)2.68246559
55Adactyly (HP:0009776)2.67023945
56Portal hypertension (HP:0001409)2.66804003
57Visual hallucinations (HP:0002367)2.66302232
58Keratoconus (HP:0000563)2.64934463
59Increased corneal curvature (HP:0100692)2.64934463
60Polycythemia (HP:0001901)2.62997024
61Generalized aminoaciduria (HP:0002909)2.62691479
62Muscle fiber splitting (HP:0003555)2.60407523
63Abnormality of aspartate family amino acid metabolism (HP:0010899)2.59698977
64Menorrhagia (HP:0000132)2.58282592
65Hypoglycemic coma (HP:0001325)2.56580041
66Abnormal respiratory motile cilium physiology (HP:0012261)2.55400239
67Central scotoma (HP:0000603)2.54056817
68Abnormality of the hepatic vasculature (HP:0006707)2.48604215
69Type I transferrin isoform profile (HP:0003642)2.47568075
70Aplasia/Hypoplasia of the spleen (HP:0010451)2.45014420
71Congenital, generalized hypertrichosis (HP:0004540)2.43729595
72Stenosis of the external auditory canal (HP:0000402)2.43231244
73Abnormal rod and cone electroretinograms (HP:0008323)2.39490195
74Focal motor seizures (HP:0011153)2.35043774
75Hemiparesis (HP:0001269)2.32212715
76Hypoproteinemia (HP:0003075)2.32022825
77Paralysis (HP:0003470)2.31482870
78Skull defect (HP:0001362)2.30541363
79Recurrent bronchitis (HP:0002837)2.29909545
80Macrocytic anemia (HP:0001972)2.28493695
81Reduced subcutaneous adipose tissue (HP:0003758)2.28186609
82Acute lymphatic leukemia (HP:0006721)2.27187861
83Patchy hypopigmentation of hair (HP:0011365)2.27060044
84Areflexia of lower limbs (HP:0002522)2.25199825
85Spontaneous abortion (HP:0005268)2.25124844
86Hyperinsulinemic hypoglycemia (HP:0000825)2.23936557
87Arterial thrombosis (HP:0004420)2.23638946
88Abnormal platelet volume (HP:0011876)2.21808194
8911 pairs of ribs (HP:0000878)2.19840948
90Pancytopenia (HP:0001876)2.19817221
91Attenuation of retinal blood vessels (HP:0007843)2.19357711
92Gonadotropin excess (HP:0000837)2.19102132
93Abolished electroretinogram (ERG) (HP:0000550)2.18734233
94Neonatal hypoglycemia (HP:0001998)2.17007340
95Hyperlipoproteinemia (HP:0010980)2.16552507
96Albinism (HP:0001022)2.15542300
97Migraine (HP:0002076)2.14287475
98Syringomyelia (HP:0003396)2.14008270
99Spinal cord lesions (HP:0100561)2.14008270
100Bruising susceptibility (HP:0000978)2.13158745
101Abnormality of the prostate (HP:0008775)2.12824664
102Cellulitis (HP:0100658)2.12758362
103Chest pain (HP:0100749)2.09414562
104Easy fatigability (HP:0003388)2.08623223
105Decreased activity of mitochondrial respiratory chain (HP:0008972)2.06807691
106Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.06807691
107Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.05076006
108Microvesicular hepatic steatosis (HP:0001414)2.04450425
109Bulbous nose (HP:0000414)2.02808410
110Mucosal telangiectasiae (HP:0100579)2.02805388
111Hepatic necrosis (HP:0002605)2.01031078
112Dry hair (HP:0011359)1.97587032
113Lymphedema (HP:0001004)1.97564253
114Interstitial pulmonary disease (HP:0006530)1.97005518
115Hypothermia (HP:0002045)1.96811842
116Abnormality of endocrine pancreas physiology (HP:0012093)1.96625000
117Abnormality of the pancreatic islet cells (HP:0006476)1.96625000
118Absent eyebrow (HP:0002223)1.96267544
119Congenital hepatic fibrosis (HP:0002612)1.94006411
120Methylmalonic aciduria (HP:0012120)1.93372018
121Microretrognathia (HP:0000308)1.93330408
122Increased neuronal autofluorescent lipopigment (HP:0002074)1.93273067
123Facial diplegia (HP:0001349)1.91599763
124Hypoplasia of the thymus (HP:0000778)1.91296139
125Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.91293270
126Abnormal protein N-linked glycosylation (HP:0012347)1.91293270
127Abnormal protein glycosylation (HP:0012346)1.91293270
128Abnormal glycosylation (HP:0012345)1.91293270
129Nonimmune hydrops fetalis (HP:0001790)1.90726227
130Pigmentary retinal degeneration (HP:0001146)1.90342268
131Aortic aneurysm (HP:0004942)1.89577810
132Autoimmune hemolytic anemia (HP:0001890)1.89163919
133Erythema (HP:0010783)1.89106638
134Fatigue (HP:0012378)1.88489460
135Abnormality of T cells (HP:0002843)1.88178880
136Gastrointestinal stroma tumor (HP:0100723)1.87759687
137Thrombophlebitis (HP:0004418)1.86847004
138Beaking of vertebral bodies (HP:0004568)1.85575501
139Arterial tortuosity (HP:0005116)1.84838034
140Thick nail (HP:0001805)1.84678294
141Orchitis (HP:0100796)1.83208300
142White forelock (HP:0002211)1.82469060
143Porencephaly (HP:0002132)1.82190248
144Symptomatic seizures (HP:0011145)1.81802882
145Decreased skull ossification (HP:0004331)1.81662889
146Increased mean platelet volume (HP:0011877)1.81545793
147Insulin-resistant diabetes mellitus (HP:0000831)1.80880417
148Recurrent viral infections (HP:0004429)1.80541617
149Disproportionate short-trunk short stature (HP:0003521)1.78853426
150Hyporeflexia of lower limbs (HP:0002600)1.78399934
151Agammaglobulinemia (HP:0004432)1.76492165
152Methylmalonic acidemia (HP:0002912)1.76268607
153IgG deficiency (HP:0004315)1.76051463
154Asymmetric septal hypertrophy (HP:0001670)1.75588046
155Autoimmune thrombocytopenia (HP:0001973)1.75527597
156Hepatocellular necrosis (HP:0001404)1.75153935
157Visceral angiomatosis (HP:0100761)1.74211856
158Gastrointestinal inflammation (HP:0004386)1.73503991
159Long foot (HP:0001833)1.73241463
160Atrioventricular block (HP:0001678)1.72849153
161Growth hormone excess (HP:0000845)1.72838219
162Myocardial infarction (HP:0001658)1.72648357
163Absent rod-and cone-mediated responses on ERG (HP:0007688)1.71933499
164Panhypogammaglobulinemia (HP:0003139)1.70937128
165Rhinitis (HP:0012384)1.70630085
166Lymphopenia (HP:0001888)1.70207190
167Vascular tortuosity (HP:0004948)1.68455214
168Absent hand (HP:0004050)1.62259057

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE16.33820366
2INSRR5.11560035
3TGFBR13.73628262
4NME23.51162386
5MAP2K33.08996439
6KDR3.07107967
7TGFBR23.06770316
8MUSK3.05208647
9KIT2.93154009
10BMPR1B2.92942353
11MAP4K12.44270657
12PBK2.20474166
13TEC2.07410592
14FER2.05447089
15MAP3K122.05244881
16STK162.04552575
17MST41.99330677
18EPHB21.92395101
19FLT31.86691384
20MATK1.83328735
21BTK1.80786737
22TSSK61.80066581
23MYLK1.78307526
24MKNK11.67139985
25TNIK1.65281608
26RPS6KB21.60106602
27ERBB41.54837271
28MAPKAPK51.51320288
29MAP4K21.50132117
30TXK1.46971689
31NUAK11.45221333
32EEF2K1.44415275
33CDK191.42690470
34JAK31.36153158
35MAP2K61.34468117
36PTK2B1.33807257
37IKBKE1.33185791
38PRKG21.31736921
39DYRK31.27144574
40CDK81.26959143
41WEE11.23494320
42ZAP701.22826596
43TBK11.22626338
44ACVR1B1.20451568
45CSF1R1.04898999
46VRK11.04847640
47PIK3CG1.02619856
48DAPK21.01788210
49IKBKB1.01768305
50GRK11.01733436
51PASK0.98960086
52ADRBK20.98873727
53BCKDK0.97559873
54EIF2AK30.97539385
55ITK0.93888930
56STK100.91841920
57CCNB10.91564843
58PNCK0.90856619
59MAPKAPK30.90472012
60FES0.89726254
61IRAK40.87526196
62PAK40.87207996
63SYK0.87013287
64BRD40.86485495
65LRRK20.84727535
66NLK0.81780783
67MKNK20.80728261
68CAMKK20.78239192
69PLK20.76744242
70STK390.75436358
71ADRBK10.74351762
72RPS6KA40.74125874
73PIK3CA0.73136901
74PKN20.70305102
75MAP3K60.70179973
76IRAK10.66358927
77LYN0.64254838
78PIM20.63930356
79WNK30.61760276
80MAP3K110.61171875
81CAMK10.60763551
82TYK20.60263061
83MAP3K30.60169665
84MAPK120.59739676
85LCK0.59160317
86GRK50.59117705
87CHUK0.57254659
88MAPK40.57058421
89OBSCN0.56845521
90CSK0.56788874
91TAOK30.56627048
92TNK20.56366539
93ILK0.55548603
94RIPK10.54545024
95ERN10.54290099
96FGFR30.52791412
97HIPK20.51477971
98PRKCQ0.51464188
99PDK20.50994297
100SIK30.50633080
101PLK40.50080909
102PIM10.49091567
103FRK0.48923807
104BRSK20.48501774
105OXSR10.48393114
106MAPK150.48099752
107HCK0.47611844
108MAP3K140.46856361
109RPS6KA60.46837756
110TRIM280.46332982
111CLK10.45381851
112ZAK0.44610884
113PRKCE0.44600739
114DAPK30.44183258
115ERBB30.43899691
116CDK70.43612654
117PLK30.41860957
118PTK20.40512326
119PRKD20.38915130
120STK30.35224526
121RPS6KA50.33798822
122ROCK10.33232293
123DAPK10.33141137
124NEK90.32613135
125BMX0.31693955
126PINK10.31580810
127MAP3K130.31332615
128FGFR40.30452758
129MAP2K10.30208554
130RPS6KL10.29619198
131RPS6KC10.29619198
132MAP3K10.28641526
133ATR0.28309045
134PRKCD0.27510495
135PRKD10.27362507
136TRPM70.27187291
137ROCK20.27074477
138EIF2AK10.26890287
139MAPK30.26680367
140WNK40.25029547
141ABL10.24094907
142CDK90.23688315
143IGF1R0.23454435
144CAMK40.22485477
145CSNK1G10.22139497
146MAPK130.22032936
147EPHB10.21729597
148IRAK20.20708848
149INSR0.18139231
150EGFR0.17327742
151PRKCA0.16236058
152PRKG10.15627527

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.76982615
2Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.09563086
3Caffeine metabolism_Homo sapiens_hsa002323.01097509
4DNA replication_Homo sapiens_hsa030302.65519759
5Phototransduction_Homo sapiens_hsa047442.57547407
6Platelet activation_Homo sapiens_hsa046112.42144435
7Base excision repair_Homo sapiens_hsa034102.39041211
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.32392195
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.25071075
10Transcriptional misregulation in cancer_Homo sapiens_hsa052022.08554380
11Olfactory transduction_Homo sapiens_hsa047402.06753746
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.04373962
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.96370618
14Mismatch repair_Homo sapiens_hsa034301.88572511
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.84866004
16Hematopoietic cell lineage_Homo sapiens_hsa046401.79498826
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.75074888
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.73752279
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.73617248
20Leishmaniasis_Homo sapiens_hsa051401.69006637
21B cell receptor signaling pathway_Homo sapiens_hsa046621.67952759
22Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.66657107
23Herpes simplex infection_Homo sapiens_hsa051681.63367608
24Pyrimidine metabolism_Homo sapiens_hsa002401.62883933
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.61091708
26Measles_Homo sapiens_hsa051621.60953845
27Vascular smooth muscle contraction_Homo sapiens_hsa042701.57782136
28Primary immunodeficiency_Homo sapiens_hsa053401.57747089
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.55093848
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.54830701
31Folate biosynthesis_Homo sapiens_hsa007901.51720541
32Linoleic acid metabolism_Homo sapiens_hsa005911.49889628
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48987076
34RNA degradation_Homo sapiens_hsa030181.43703791
35Butanoate metabolism_Homo sapiens_hsa006501.36025175
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.31959394
37Homologous recombination_Homo sapiens_hsa034401.30976346
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.29042041
39Spliceosome_Homo sapiens_hsa030401.26132386
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.26043517
41Protein export_Homo sapiens_hsa030601.23942799
42Chemical carcinogenesis_Homo sapiens_hsa052041.23638027
43RNA polymerase_Homo sapiens_hsa030201.22119017
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22074550
45Serotonergic synapse_Homo sapiens_hsa047261.20438871
46Amoebiasis_Homo sapiens_hsa051461.18010759
47Acute myeloid leukemia_Homo sapiens_hsa052211.15481130
48Ras signaling pathway_Homo sapiens_hsa040141.14943633
49Purine metabolism_Homo sapiens_hsa002301.14812492
50Intestinal immune network for IgA production_Homo sapiens_hsa046721.14450494
51Nitrogen metabolism_Homo sapiens_hsa009101.14134488
52Leukocyte transendothelial migration_Homo sapiens_hsa046701.13637712
53Malaria_Homo sapiens_hsa051441.13376047
54Renin secretion_Homo sapiens_hsa049241.12610483
55Shigellosis_Homo sapiens_hsa051311.11885394
56Nucleotide excision repair_Homo sapiens_hsa034201.11090961
57Toll-like receptor signaling pathway_Homo sapiens_hsa046201.10901391
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.10232821
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.09505985
60Glutathione metabolism_Homo sapiens_hsa004801.03316171
61Adherens junction_Homo sapiens_hsa045201.01518883
62TGF-beta signaling pathway_Homo sapiens_hsa043501.01431395
63Peroxisome_Homo sapiens_hsa041461.01183068
64Osteoclast differentiation_Homo sapiens_hsa043800.98969135
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97701409
66Pertussis_Homo sapiens_hsa051330.97317393
67Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.97118848
68African trypanosomiasis_Homo sapiens_hsa051430.95219988
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94296287
70Influenza A_Homo sapiens_hsa051640.93975186
71Legionellosis_Homo sapiens_hsa051340.91633105
72Regulation of actin cytoskeleton_Homo sapiens_hsa048100.90262348
73Rheumatoid arthritis_Homo sapiens_hsa053230.89683147
74Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.88336391
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87057321
76TNF signaling pathway_Homo sapiens_hsa046680.86788652
77NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86783839
78Ether lipid metabolism_Homo sapiens_hsa005650.85557409
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83362796
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83045312
81Basal transcription factors_Homo sapiens_hsa030220.82500410
82Retinol metabolism_Homo sapiens_hsa008300.81471199
83Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.80390364
84Thyroid cancer_Homo sapiens_hsa052160.79952472
85ABC transporters_Homo sapiens_hsa020100.78647666
86Notch signaling pathway_Homo sapiens_hsa043300.77986700
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77604811
88Toxoplasmosis_Homo sapiens_hsa051450.76342902
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76135685
90Salivary secretion_Homo sapiens_hsa049700.75602450
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75543108
92Sulfur relay system_Homo sapiens_hsa041220.75512280
93N-Glycan biosynthesis_Homo sapiens_hsa005100.75506767
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.75326245
95Hepatitis B_Homo sapiens_hsa051610.74749836
96Sulfur metabolism_Homo sapiens_hsa009200.73429039
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.72758875
98Dilated cardiomyopathy_Homo sapiens_hsa054140.71060401
99Oxytocin signaling pathway_Homo sapiens_hsa049210.70906155
100beta-Alanine metabolism_Homo sapiens_hsa004100.70232153
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69737174
102Galactose metabolism_Homo sapiens_hsa000520.68901761
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.68863314
104Antigen processing and presentation_Homo sapiens_hsa046120.67178835
105Cell cycle_Homo sapiens_hsa041100.65856989
106Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65443755
107Prion diseases_Homo sapiens_hsa050200.65180564
108Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.65174023
109Fatty acid degradation_Homo sapiens_hsa000710.64221912
110Ovarian steroidogenesis_Homo sapiens_hsa049130.63886056
111Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63696459
112Arachidonic acid metabolism_Homo sapiens_hsa005900.63238351
113Calcium signaling pathway_Homo sapiens_hsa040200.62379929
114Autoimmune thyroid disease_Homo sapiens_hsa053200.62183416
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.61762137
116Other glycan degradation_Homo sapiens_hsa005110.61495715
117Non-homologous end-joining_Homo sapiens_hsa034500.60625677
118Hepatitis C_Homo sapiens_hsa051600.60099657
119Glycerolipid metabolism_Homo sapiens_hsa005610.58890929
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57918618
121Small cell lung cancer_Homo sapiens_hsa052220.57796651
122Prolactin signaling pathway_Homo sapiens_hsa049170.57114404
123Tryptophan metabolism_Homo sapiens_hsa003800.56302214
124Fanconi anemia pathway_Homo sapiens_hsa034600.56090810
125p53 signaling pathway_Homo sapiens_hsa041150.55878740
126Graft-versus-host disease_Homo sapiens_hsa053320.55863209
127Allograft rejection_Homo sapiens_hsa053300.54139096
128Dorso-ventral axis formation_Homo sapiens_hsa043200.53957140
129Fatty acid elongation_Homo sapiens_hsa000620.53733645
130Gap junction_Homo sapiens_hsa045400.50606831
131Long-term depression_Homo sapiens_hsa047300.49284347
132Steroid hormone biosynthesis_Homo sapiens_hsa001400.48985951
133Circadian entrainment_Homo sapiens_hsa047130.47501226
134HIF-1 signaling pathway_Homo sapiens_hsa040660.46956878
135Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46868239
136Rap1 signaling pathway_Homo sapiens_hsa040150.46369893
137Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46217688
138Pancreatic secretion_Homo sapiens_hsa049720.46069242
139HTLV-I infection_Homo sapiens_hsa051660.45158826
140Focal adhesion_Homo sapiens_hsa045100.44896701
141Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44462160
142PPAR signaling pathway_Homo sapiens_hsa033200.44213921
143ECM-receptor interaction_Homo sapiens_hsa045120.43434006
144Endocytosis_Homo sapiens_hsa041440.43317975
145Fatty acid metabolism_Homo sapiens_hsa012120.43184943
146Salmonella infection_Homo sapiens_hsa051320.43136913
147Apoptosis_Homo sapiens_hsa042100.43080256
148RNA transport_Homo sapiens_hsa030130.42368994
149cAMP signaling pathway_Homo sapiens_hsa040240.41903724
150Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39747667
151Regulation of autophagy_Homo sapiens_hsa041400.39529166
152Complement and coagulation cascades_Homo sapiens_hsa046100.38500725
153Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.35649883
154Pathways in cancer_Homo sapiens_hsa052000.35289264
155Adipocytokine signaling pathway_Homo sapiens_hsa049200.34348120
156Insulin resistance_Homo sapiens_hsa049310.33917962
157Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33009473
158Chronic myeloid leukemia_Homo sapiens_hsa052200.32597157
159Epstein-Barr virus infection_Homo sapiens_hsa051690.30418414
160Propanoate metabolism_Homo sapiens_hsa006400.28244032
161Chemokine signaling pathway_Homo sapiens_hsa040620.26059531
162Asthma_Homo sapiens_hsa053100.23404300

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