MYCN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1enteric nervous system development (GO:0048484)7.11826217
2sympathetic nervous system development (GO:0048485)6.76483040
3positive regulation of transcription regulatory region DNA binding (GO:2000679)6.22473376
4positive regulation of cell cycle checkpoint (GO:1901978)5.19106000
5behavioral response to nicotine (GO:0035095)5.13634118
6regulation of cardioblast proliferation (GO:0003264)4.84209876
7regulation of secondary heart field cardioblast proliferation (GO:0003266)4.84209876
8DNA unwinding involved in DNA replication (GO:0006268)4.69121682
9ribosomal small subunit assembly (GO:0000028)4.68326885
10regulation of gene silencing by RNA (GO:0060966)4.62507470
11regulation of posttranscriptional gene silencing (GO:0060147)4.62507470
12regulation of gene silencing by miRNA (GO:0060964)4.62507470
13regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.61458653
14regulation of mitotic spindle checkpoint (GO:1903504)4.61458653
15tongue development (GO:0043586)4.50295613
16IMP biosynthetic process (GO:0006188)4.49767432
17dopaminergic neuron differentiation (GO:0071542)4.48314289
18coronary vasculature morphogenesis (GO:0060977)4.48101342
19negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.42068666
20maturation of SSU-rRNA (GO:0030490)4.34112834
21negative regulation of dendrite morphogenesis (GO:0050774)4.29236274
22pre-miRNA processing (GO:0031054)4.23475672
23DNA replication initiation (GO:0006270)4.19706505
24formation of translation preinitiation complex (GO:0001731)4.17727227
25nucleobase biosynthetic process (GO:0046112)4.14908122
26DNA strand elongation involved in DNA replication (GO:0006271)4.09101004
27tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.08687340
28RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.08687340
29cell migration involved in heart development (GO:0060973)3.98311924
30viral transcription (GO:0019083)3.94884115
31DNA strand elongation (GO:0022616)3.93052550
32somatic diversification of immune receptors via somatic mutation (GO:0002566)3.91365029
33somatic hypermutation of immunoglobulin genes (GO:0016446)3.91365029
34nuclear pore organization (GO:0006999)3.91351220
35IMP metabolic process (GO:0046040)3.91120757
36translational termination (GO:0006415)3.87560695
37DNA replication-dependent nucleosome organization (GO:0034723)3.86042029
38DNA replication-dependent nucleosome assembly (GO:0006335)3.86042029
39cartilage morphogenesis (GO:0060536)3.80688377
40telomere maintenance via semi-conservative replication (GO:0032201)3.76406937
41regulation of helicase activity (GO:0051095)3.75700689
42ribosome biogenesis (GO:0042254)3.75567368
43DNA deamination (GO:0045006)3.69271073
44pore complex assembly (GO:0046931)3.63950928
45purine nucleobase biosynthetic process (GO:0009113)3.62261338
46peptidyl-arginine omega-N-methylation (GO:0035247)3.60438624
47peripheral nervous system neuron development (GO:0048935)3.59817701
48ribosomal small subunit biogenesis (GO:0042274)3.58979170
49protein localization to kinetochore (GO:0034501)3.58613200
50establishment of integrated proviral latency (GO:0075713)3.58531257
51nuclear pore complex assembly (GO:0051292)3.57621064
52histone arginine methylation (GO:0034969)3.56768756
53ribonucleoprotein complex biogenesis (GO:0022613)3.56728619
54translational elongation (GO:0006414)3.56626006
55cardiac chamber formation (GO:0003207)3.53111977
56retinal rod cell development (GO:0046548)3.52900379
57cell migration in hindbrain (GO:0021535)3.51275554
58negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.47843249
59cardiac ventricle formation (GO:0003211)3.47586385
60pseudouridine synthesis (GO:0001522)3.47530905
61mitotic nuclear envelope disassembly (GO:0007077)3.46646797
62nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.46641501
63folic acid-containing compound biosynthetic process (GO:0009396)3.45559426
64negative regulation of histone methylation (GO:0031061)3.44101116
65paraxial mesoderm development (GO:0048339)3.43494983
66negative regulation of striated muscle cell apoptotic process (GO:0010664)3.42949148
67translational initiation (GO:0006413)3.41559882
68mitotic metaphase plate congression (GO:0007080)3.36138073
69ganglion development (GO:0061548)3.32157726
70regulation of heart morphogenesis (GO:2000826)3.31871005
71regulation of histone H3-K9 methylation (GO:0051570)3.29438257
72DNA duplex unwinding (GO:0032508)3.29060869
73positive regulation of cell cycle G2/M phase transition (GO:1902751)3.28284925
74positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)3.28284925
75regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.27613414
76DNA geometric change (GO:0032392)3.27211692
77ribosomal large subunit biogenesis (GO:0042273)3.23182791
78nuclear envelope disassembly (GO:0051081)3.22978325
79membrane disassembly (GO:0030397)3.22978325
80regulation of spindle checkpoint (GO:0090231)3.22654102
81telomere maintenance via recombination (GO:0000722)3.21587625
82heterochromatin organization (GO:0070828)3.19220653
83negative regulation of DNA repair (GO:0045738)3.16150769
84regulation of centrosome duplication (GO:0010824)3.15848938
85kinetochore organization (GO:0051383)3.15586363
86negative regulation of RNA splicing (GO:0033119)3.13393788
87regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.13028760
88mitotic chromosome condensation (GO:0007076)3.12239255
89regulation of centrosome cycle (GO:0046605)3.11761160
90negative regulation of mRNA processing (GO:0050686)3.11275555
91mitotic recombination (GO:0006312)3.11161294
92rRNA processing (GO:0006364)3.11000633
93kinetochore assembly (GO:0051382)3.09856304
94chromatin remodeling at centromere (GO:0031055)3.07982917
95spliceosomal snRNP assembly (GO:0000387)3.07954275
96metaphase plate congression (GO:0051310)3.06064301
97telomere maintenance via telomere lengthening (GO:0010833)3.06024814
98cellular protein complex disassembly (GO:0043624)3.04266266
99histone H4-K12 acetylation (GO:0043983)3.02592256
100protein localization to chromosome, centromeric region (GO:0071459)3.02065298
101adult heart development (GO:0007512)3.01323552
102regulation of mRNA catabolic process (GO:0061013)3.01120212
103viral life cycle (GO:0019058)3.00975985
104mitotic sister chromatid cohesion (GO:0007064)3.00966333
105CENP-A containing nucleosome assembly (GO:0034080)3.00862350
106regulation of nuclear cell cycle DNA replication (GO:0033262)2.99732107
107rRNA metabolic process (GO:0016072)2.99477849
108peptidyl-arginine methylation (GO:0018216)2.98977012
109peptidyl-arginine N-methylation (GO:0035246)2.98977012
110protein complex disassembly (GO:0043241)2.97705666
111definitive hemopoiesis (GO:0060216)2.96837459
112DNA replication checkpoint (GO:0000076)2.96562010
113ribosome assembly (GO:0042255)2.95812126
114histone exchange (GO:0043486)2.95294735
115protein complex localization (GO:0031503)2.95064479
116suckling behavior (GO:0001967)2.94948747
117regulation of gene silencing (GO:0060968)2.94758556
118SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.94421316
119regulation of translational fidelity (GO:0006450)2.93626813
120nucleotide-excision repair, DNA gap filling (GO:0006297)2.92301678
121nuclear-transcribed mRNA catabolic process (GO:0000956)2.90022651
122DNA replication-independent nucleosome organization (GO:0034724)2.87800446
123DNA replication-independent nucleosome assembly (GO:0006336)2.87800446
124regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.87250204
125histone H2A acetylation (GO:0043968)2.85922558
126RNA splicing, via transesterification reactions (GO:0000375)2.85905783
127spliceosomal complex assembly (GO:0000245)2.85740918
128regulation of stem cell maintenance (GO:2000036)2.84971579
129cotranslational protein targeting to membrane (GO:0006613)2.84573129
130establishment of apical/basal cell polarity (GO:0035089)2.84497229
131RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.84353917
132mRNA splicing, via spliceosome (GO:0000398)2.84353917
133nodal signaling pathway (GO:0038092)2.84273108
134protein targeting to ER (GO:0045047)2.83728638
135termination of RNA polymerase II transcription (GO:0006369)2.83419652
136mitotic sister chromatid segregation (GO:0000070)2.82072113
137negative regulation of chromosome segregation (GO:0051985)2.80712733
138regulation of cardiac muscle cell apoptotic process (GO:0010665)2.80569439
139macromolecular complex disassembly (GO:0032984)2.80006074
140negative regulation of mRNA metabolic process (GO:1903312)2.79516918
141RNA catabolic process (GO:0006401)2.77715188
142viral mRNA export from host cell nucleus (GO:0046784)2.77711997
143mismatch repair (GO:0006298)2.77347983
144mRNA catabolic process (GO:0006402)2.77030357
145sister chromatid segregation (GO:0000819)2.76907489
146regulation of transcription regulatory region DNA binding (GO:2000677)2.72010408
147mesenchymal cell proliferation (GO:0010463)2.71142360
148ATP-dependent chromatin remodeling (GO:0043044)2.68195575
149regulation of respiratory gaseous exchange (GO:0043576)2.67335358
150retinal cone cell development (GO:0046549)2.64909307
151spinal cord motor neuron differentiation (GO:0021522)2.64628250
152double-strand break repair via nonhomologous end joining (GO:0006303)2.63903466
153non-recombinational repair (GO:0000726)2.63903466
154chromatin assembly or disassembly (GO:0006333)2.62577197
155negative regulation of dendrite development (GO:2000171)2.59839709
156eye photoreceptor cell development (GO:0042462)2.54709797
157chromatin assembly (GO:0031497)2.54214518
158negative regulation of mitotic sister chromatid separation (GO:2000816)2.53848881
159negative regulation of sister chromatid segregation (GO:0033046)2.53848881
160negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.53848881
161negative regulation of mitotic sister chromatid segregation (GO:0033048)2.53848881

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.78927768
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.67434238
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.47262163
4STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.45937654
5GATA1_22025678_ChIP-Seq_K562_Human3.45927641
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.39552391
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.35681101
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.22478171
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.13765288
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.01784294
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.01370791
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.84542515
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.78306228
14KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.57122671
15KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.57122671
16KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.57122671
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.50693891
18EZH2_22144423_ChIP-Seq_EOC_Human2.43926433
19* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.43555392
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.34251846
21POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.30578521
22XRN2_22483619_ChIP-Seq_HELA_Human2.30411153
23EST1_17652178_ChIP-ChIP_JURKAT_Human2.28698241
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.22009525
25ETS1_20019798_ChIP-Seq_JURKAT_Human2.20966753
26* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.12738942
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.11171853
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.07667844
29E2F1_18555785_ChIP-Seq_MESCs_Mouse2.02840845
30SOX2_16153702_ChIP-ChIP_HESCs_Human1.98970355
31* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.98816119
32KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.96538450
33* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.94289721
34POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.91836025
35* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.89315651
36* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.87918595
37* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85510139
38* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.84946471
39GABP_17652178_ChIP-ChIP_JURKAT_Human1.83342448
40KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.83177308
41MYC_22102868_ChIP-Seq_BL_Human1.81285516
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.79673555
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.79184704
44TTF2_22483619_ChIP-Seq_HELA_Human1.77630418
45* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.77482443
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.76042841
47* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.73475022
48NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.72546604
49ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71518293
50VDR_23849224_ChIP-Seq_CD4+_Human1.71107068
51* E2F1_21310950_ChIP-Seq_MCF-7_Human1.69764515
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.68415505
53EGR1_19374776_ChIP-ChIP_THP-1_Human1.67694200
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.64040198
55* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.64038431
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.63395641
57FOXP3_21729870_ChIP-Seq_TREG_Human1.61637362
58ESR1_15608294_ChIP-ChIP_MCF-7_Human1.58326116
59GABP_19822575_ChIP-Seq_HepG2_Human1.58189259
60* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.57776864
61AR_21909140_ChIP-Seq_LNCAP_Human1.57595113
62NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.55162775
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.54441093
64* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.52987683
65* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.52753658
66HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.51839683
67YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50446497
68DCP1A_22483619_ChIP-Seq_HELA_Human1.47422435
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47326702
70CIITA_25753668_ChIP-Seq_RAJI_Human1.46597970
71* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.45896270
72E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.42328413
73ELF1_17652178_ChIP-ChIP_JURKAT_Human1.37994201
74YY1_21170310_ChIP-Seq_MESCs_Mouse1.37869633
75KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.36900871
76MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36016073
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.35626886
78HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.34844170
79SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34004890
80* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.33120713
81* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.31984742
82* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.31578290
83GATA1_26923725_Chip-Seq_HPCs_Mouse1.30798525
84ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.29498629
85NANOG_16153702_ChIP-ChIP_HESCs_Human1.29143976
86FUS_26573619_Chip-Seq_HEK293_Human1.26400236
87ERG_21242973_ChIP-ChIP_JURKAT_Human1.25438668
88EWS_26573619_Chip-Seq_HEK293_Human1.23014057
89EZH2_27304074_Chip-Seq_ESCs_Mouse1.22536967
90* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.22506343
91KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21178721
92MYC_18940864_ChIP-ChIP_HL60_Human1.20088552
93RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19999360
94SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.19951531
95KDM5A_27292631_Chip-Seq_BREAST_Human1.18228568
96TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.18040091
97NANOG_21062744_ChIP-ChIP_HESCs_Human1.17545844
98* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.17511675
99* ETV1_20927104_ChIP-Seq_GIST48_Human1.16324153
100CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.13811210
101FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13620244
102* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.13089689
103* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.12454616
104ELK1_19687146_ChIP-ChIP_HELA_Human1.11185916
105HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11046778
106* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.10898662
107* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.10391769
108* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.08211024
109DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07525117
110POU5F1_16518401_ChIP-PET_MESCs_Mouse1.07496910
111NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05465272
112ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05357321
113SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03554272
114SALL1_21062744_ChIP-ChIP_HESCs_Human1.01368860
115SRF_21415370_ChIP-Seq_HL-1_Mouse1.01025438
116* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00940435
117IRF1_19129219_ChIP-ChIP_H3396_Human0.99483680
118* SCL_19346495_ChIP-Seq_HPC-7_Human0.99466215
119CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.99280477
120DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99223083
121* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.97875126
122IGF1R_20145208_ChIP-Seq_DFB_Human0.96845056
123CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96826552
124* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96508967
125E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95391369
126CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95283943
127* TCF4_18268006_ChIP-ChIP_LS174T_Human0.95222180
128NFE2_27457419_Chip-Seq_LIVER_Mouse0.94905956
129SOX9_26525672_Chip-Seq_HEART_Mouse0.92604161
130PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92301011
131JARID2_20064375_ChIP-Seq_MESCs_Mouse0.91637943
132* RBPJ_21746931_ChIP-Seq_IB4_Human0.90947038
133SUZ12_27294783_Chip-Seq_NPCs_Mouse0.89482070
134POU3F2_20337985_ChIP-ChIP_501MEL_Human0.86529446
135* RING1B_27294783_Chip-Seq_NPCs_Mouse0.85803681
136RNF2_27304074_Chip-Seq_NSC_Mouse0.84681506
137SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.84404963
138* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.83345668
139* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.82445136
140SMAD3_21741376_ChIP-Seq_EPCs_Human0.79627038
141* REST_21632747_ChIP-Seq_MESCs_Mouse0.79592316
142PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.77944131

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy6.25266535
2MP0002638_abnormal_pupillary_reflex4.82560201
3MP0002009_preneoplasia3.92461828
4MP0010094_abnormal_chromosome_stability3.86892544
5MP0004957_abnormal_blastocyst_morpholog3.79849001
6MP0003693_abnormal_embryo_hatching3.71989867
7MP0010030_abnormal_orbit_morphology3.46645116
8MP0003111_abnormal_nucleus_morphology3.45838901
9MP0008057_abnormal_DNA_replication3.33968838
10MP0003077_abnormal_cell_cycle3.32495420
11MP0008058_abnormal_DNA_repair3.02981079
12MP0003123_paternal_imprinting3.00074482
13MP0004133_heterotaxia2.76126748
14MP0008007_abnormal_cellular_replicative2.61985928
15MP0006292_abnormal_olfactory_placode2.50422293
16MP0010386_abnormal_urinary_bladder2.36787409
17* MP0001730_embryonic_growth_arrest2.12904616
18MP0008932_abnormal_embryonic_tissue2.12618685
19MP0002084_abnormal_developmental_patter2.07356826
20MP0000350_abnormal_cell_proliferation2.04193386
21MP0003119_abnormal_digestive_system2.03611383
22MP0003315_abnormal_perineum_morphology1.99845516
23MP0003890_abnormal_embryonic-extraembry1.95274661
24MP0010352_gastrointestinal_tract_polyps1.94105010
25MP0005253_abnormal_eye_physiology1.94003575
26* MP0001697_abnormal_embryo_size1.93138182
27* MP0005380_embryogenesis_phenotype1.92800226
28* MP0001672_abnormal_embryogenesis/_devel1.92800226
29MP0001293_anophthalmia1.91847655
30* MP0002085_abnormal_embryonic_tissue1.91345254
31MP0003121_genomic_imprinting1.91202072
32MP0003941_abnormal_skin_development1.87484820
33MP0008877_abnormal_DNA_methylation1.87184747
34MP0006276_abnormal_autonomic_nervous1.86028244
35MP0002396_abnormal_hematopoietic_system1.84902764
36MP0006072_abnormal_retinal_apoptosis1.84168443
37MP0005551_abnormal_eye_electrophysiolog1.80713736
38* MP0004197_abnormal_fetal_growth/weight/1.79644686
39* MP0003984_embryonic_growth_retardation1.70815703
40MP0002653_abnormal_ependyma_morphology1.70785730
41* MP0002086_abnormal_extraembryonic_tissu1.69838447
42* MP0002088_abnormal_embryonic_growth/wei1.68869886
43MP0004808_abnormal_hematopoietic_stem1.64649734
44MP0000537_abnormal_urethra_morphology1.60711329
45* MP0002080_prenatal_lethality1.59727030
46MP0002249_abnormal_larynx_morphology1.53128822
47MP0003786_premature_aging1.52753510
48MP0005187_abnormal_penis_morphology1.52741822
49* MP0003567_abnormal_fetal_cardiomyocyte1.51923165
50MP0005197_abnormal_uvea_morphology1.50933303
51MP0003806_abnormal_nucleotide_metabolis1.49043310
52MP0005391_vision/eye_phenotype1.43699381
53MP0003283_abnormal_digestive_organ1.43293445
54MP0000631_abnormal_neuroendocrine_gland1.43208433
55MP0000490_abnormal_crypts_of1.39627305
56MP0000313_abnormal_cell_death1.39120902
57MP0002184_abnormal_innervation1.36633353
58MP0005367_renal/urinary_system_phenotyp1.32796046
59MP0000516_abnormal_urinary_system1.32796046
60MP0005075_abnormal_melanosome_morpholog1.29140334
61MP0002102_abnormal_ear_morphology1.27703731
62MP0000049_abnormal_middle_ear1.20452636
63MP0000778_abnormal_nervous_system1.18739060
64MP0003136_yellow_coat_color1.18067211
65MP0005195_abnormal_posterior_eye1.17169230
66MP0005499_abnormal_olfactory_system1.17006052
67MP0005394_taste/olfaction_phenotype1.17006052
68MP0002210_abnormal_sex_determination1.14341389
69MP0010307_abnormal_tumor_latency1.13413249
70MP0009697_abnormal_copulation1.12257411
71MP0001145_abnormal_male_reproductive1.10836958
72MP0002092_abnormal_eye_morphology1.08650421
73MP0004270_analgesia1.08642458
74MP0001529_abnormal_vocalization1.08286007
75MP0001915_intracranial_hemorrhage1.08077092
76MP0003718_maternal_effect1.07967340
77MP0000538_abnormal_urinary_bladder1.07490425
78MP0001286_abnormal_eye_development1.06685927
79* MP0002752_abnormal_somatic_nervous1.04076894
80MP0002019_abnormal_tumor_incidence1.02390772
81* MP0002111_abnormal_tail_morphology1.00854415
82MP0000955_abnormal_spinal_cord1.00623976
83MP0003937_abnormal_limbs/digits/tail_de0.99780778
84* MP0003861_abnormal_nervous_system0.97998339
85* MP0002697_abnormal_eye_size0.96943830
86MP0002163_abnormal_gland_morphology0.96221812
87MP0009278_abnormal_bone_marrow0.95697199
88* MP0002882_abnormal_neuron_morphology0.95027346
89MP0008789_abnormal_olfactory_epithelium0.93732857
90MP0002751_abnormal_autonomic_nervous0.92361452
91MP0002938_white_spotting0.91030790
92MP0001270_distended_abdomen0.90218257
93MP0009053_abnormal_anal_canal0.89445887
94MP0001849_ear_inflammation0.89281832
95* MP0002114_abnormal_axial_skeleton0.88102212
96* MP0003943_abnormal_hepatobiliary_system0.87936500
97MP0003942_abnormal_urinary_system0.87303318
98* MP0003935_abnormal_craniofacial_develop0.86703179
99MP0000678_abnormal_parathyroid_gland0.86492872
100MP0001545_abnormal_hematopoietic_system0.85924471
101MP0005397_hematopoietic_system_phenotyp0.85924471
102MP0001299_abnormal_eye_distance/0.84680800
103MP0001188_hyperpigmentation0.83952968
104MP0000653_abnormal_sex_gland0.83786784
105MP0005423_abnormal_somatic_nervous0.83770344
106MP0004811_abnormal_neuron_physiology0.82683019
107* MP0002925_abnormal_cardiovascular_devel0.82035139
108* MP0002932_abnormal_joint_morphology0.80945483
109MP0002233_abnormal_nose_morphology0.79416828
110MP0003385_abnormal_body_wall0.79239257
111MP0002735_abnormal_chemical_nociception0.78905812
112MP0001929_abnormal_gametogenesis0.78262183
113MP0005174_abnormal_tail_pigmentation0.78082474
114MP0008770_decreased_survivor_rate0.77683650
115MP0003755_abnormal_palate_morphology0.77035752
116MP0000428_abnormal_craniofacial_morphol0.76398108
117MP0001324_abnormal_eye_pigmentation0.75892703
118MP0003122_maternal_imprinting0.75618484
119* MP0002152_abnormal_brain_morphology0.75500464
120MP0001177_atelectasis0.74674414
121* MP0000432_abnormal_head_morphology0.74456679
122MP0000733_abnormal_muscle_development0.74280601
123MP0000703_abnormal_thymus_morphology0.73851387
124MP0005377_hearing/vestibular/ear_phenot0.73371838
125MP0003878_abnormal_ear_physiology0.73371838
126MP0002160_abnormal_reproductive_system0.72795006
127MP0000647_abnormal_sebaceous_gland0.72631656
128MP0009379_abnormal_foot_pigmentation0.71616471
129MP0002127_abnormal_cardiovascular_syste0.71335476
130MP0003938_abnormal_ear_development0.69308708
131MP0002075_abnormal_coat/hair_pigmentati0.69246512
132MP0002234_abnormal_pharynx_morphology0.69241335
133MP0004233_abnormal_muscle_weight0.68328531
134MP0009672_abnormal_birth_weight0.67939517
135MP0005266_abnormal_metabolism0.67596779
136MP0002116_abnormal_craniofacial_bone0.67493976
137MP0005623_abnormal_meninges_morphology0.67418024
138* MP0000477_abnormal_intestine_morphology0.66802459
139MP0002734_abnormal_mechanical_nocicepti0.66165961
140MP0001119_abnormal_female_reproductive0.65793623
141MP0003787_abnormal_imprinting0.65686530
142MP0001348_abnormal_lacrimal_gland0.65416113
143MP0003698_abnormal_male_reproductive0.64929017
144MP0009703_decreased_birth_body0.64689963
145MP0000358_abnormal_cell_content/0.64336289
146* MP0002081_perinatal_lethality0.64300662
147MP0009745_abnormal_behavioral_response0.63882534
148MP0003221_abnormal_cardiomyocyte_apopto0.63481634

Predicted human phenotypes

RankGene SetZ-score
1Subcapsular cataract (HP:0000523)7.81726563
2Central scotoma (HP:0000603)7.49360682
3Scotoma (HP:0000575)6.57476826
4Septo-optic dysplasia (HP:0100842)5.80512050
5Ependymoma (HP:0002888)4.51100348
6Colon cancer (HP:0003003)4.49511811
7Bony spicule pigmentary retinopathy (HP:0007737)4.39346586
8Medulloblastoma (HP:0002885)4.38509417
9Polar cataract (HP:0010696)4.37116381
10Constricted visual fields (HP:0001133)4.07349894
11Birth length less than 3rd percentile (HP:0003561)3.92169585
12Aplastic anemia (HP:0001915)3.84686782
13Asymmetry of the thorax (HP:0001555)3.57560071
14Selective tooth agenesis (HP:0001592)3.56975060
15Reticulocytopenia (HP:0001896)3.54865935
16Absent septum pellucidum (HP:0001331)3.38005731
17Abnormality of the septum pellucidum (HP:0007375)3.36285676
18Abnormality of the astrocytes (HP:0100707)3.23090246
19Astrocytoma (HP:0009592)3.23090246
20Rib fusion (HP:0000902)3.17000952
21Neoplasm of the oral cavity (HP:0100649)3.16533981
22Rhabdomyosarcoma (HP:0002859)3.15390639
23Abolished electroretinogram (ERG) (HP:0000550)3.13513676
24Abnormality of the labia minora (HP:0012880)3.09671915
25Abnormality of cells of the erythroid lineage (HP:0012130)3.05099998
26Attenuation of retinal blood vessels (HP:0007843)3.01816876
27Amblyopia (HP:0000646)2.95112500
28Abnormal number of incisors (HP:0011064)2.92630245
29Agnosia (HP:0010524)2.88608685
30* Supernumerary spleens (HP:0009799)2.88555403
31Dyschromatopsia (HP:0007641)2.78626893
32Neoplasm of striated muscle (HP:0009728)2.76930362
33Bilateral microphthalmos (HP:0007633)2.76672681
34Abnormal number of erythroid precursors (HP:0012131)2.75610856
35Amaurosis fugax (HP:0100576)2.74666554
36Absent thumb (HP:0009777)2.72900760
37Type II diabetes mellitus (HP:0005978)2.72728389
38Glioma (HP:0009733)2.72327523
39Abnormal lung lobation (HP:0002101)2.71396337
40Breast hypoplasia (HP:0003187)2.70797527
41Rectal fistula (HP:0100590)2.69429025
42Rectovaginal fistula (HP:0000143)2.69429025
43Oral leukoplakia (HP:0002745)2.69105994
44Myelodysplasia (HP:0002863)2.67550571
45Aplasia/hypoplasia of the humerus (HP:0006507)2.67508303
46Abdominal situs inversus (HP:0003363)2.66930784
47Abnormality of abdominal situs (HP:0011620)2.66930784
48Degeneration of anterior horn cells (HP:0002398)2.65442028
49Abnormality of the anterior horn cell (HP:0006802)2.65442028
50Patellar aplasia (HP:0006443)2.64588592
51Absent radius (HP:0003974)2.64309789
52Exotropia (HP:0000577)2.64171076
53Chromosomal breakage induced by crosslinking agents (HP:0003221)2.63912969
54Carpal bone hypoplasia (HP:0001498)2.63296887
55Chromsome breakage (HP:0040012)2.61907442
56Optic nerve hypoplasia (HP:0000609)2.59780157
57Missing ribs (HP:0000921)2.58235049
58Cortical dysplasia (HP:0002539)2.54819676
59Basal cell carcinoma (HP:0002671)2.49966368
60Abnormality of the ileum (HP:0001549)2.48072624
61Aplasia involving forearm bones (HP:0009822)2.46050931
62Absent forearm bone (HP:0003953)2.46050931
63Aplasia/Hypoplasia of the patella (HP:0006498)2.44849127
64Meckel diverticulum (HP:0002245)2.42228764
65External ophthalmoplegia (HP:0000544)2.40687804
66Ectopic kidney (HP:0000086)2.40549584
67Short humerus (HP:0005792)2.39009466
68Proximal placement of thumb (HP:0009623)2.37129991
69Vaginal fistula (HP:0004320)2.35255281
70Anal stenosis (HP:0002025)2.35244205
71Intestinal fistula (HP:0100819)2.32844006
72Stenosis of the external auditory canal (HP:0000402)2.30229210
73Microretrognathia (HP:0000308)2.29276265
74Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.28064926
75Aplasia/Hypoplasia of the sternum (HP:0006714)2.24528248
76Facial hemangioma (HP:0000329)2.22490446
77Nephroblastoma (Wilms tumor) (HP:0002667)2.21243279
78Neoplasm of the pancreas (HP:0002894)2.20775955
79Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.19529854
80Neuroblastoma (HP:0003006)2.18492023
81Primitive neuroectodermal tumor (HP:0030065)2.18492023
82Neuroblastic tumors (HP:0004376)2.18492023
83Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.18492023
8411 pairs of ribs (HP:0000878)2.17733499
85Atresia of the external auditory canal (HP:0000413)2.17072391
86Deviation of the thumb (HP:0009603)2.16905444
87Short 4th metacarpal (HP:0010044)2.12265454
88Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.12265454
89Embryonal renal neoplasm (HP:0011794)2.12210881
90Abnormality of the preputium (HP:0100587)2.09827403
91High anterior hairline (HP:0009890)2.09706641
92Small intestinal stenosis (HP:0012848)2.08736903
93Duodenal stenosis (HP:0100867)2.08736903
94Abnormality of chromosome stability (HP:0003220)2.08638148
95Increased nuchal translucency (HP:0010880)2.08319245
96Aplasia/Hypoplasia of the uvula (HP:0010293)2.08299613
97Shawl scrotum (HP:0000049)2.08100259
98Chorioretinal atrophy (HP:0000533)2.06877653
99Abnormality of macular pigmentation (HP:0008002)2.05635424
100Supernumerary bones of the axial skeleton (HP:0009144)2.03913569
101Volvulus (HP:0002580)2.02214015
102Hemivertebrae (HP:0002937)2.00856072
103Sloping forehead (HP:0000340)2.00700728
104Pallor (HP:0000980)2.00699895
105Renal duplication (HP:0000075)2.00611131
106Premature graying of hair (HP:0002216)2.00554961
107Posterior subcapsular cataract (HP:0007787)12.3840778
108Macrocytic anemia (HP:0001972)1.99460273
109Atrophy/Degeneration involving motor neurons (HP:0007373)1.98730683
110Partial agenesis of the corpus callosum (HP:0001338)1.98501854
111Bone marrow hypocellularity (HP:0005528)1.97684249
112Bicornuate uterus (HP:0000813)1.97568835
113Supernumerary ribs (HP:0005815)1.95755078
114Optic disc pallor (HP:0000543)1.95119163
115Acute lymphatic leukemia (HP:0006721)1.93464722
116Megalocornea (HP:0000485)1.92662068
117Aplasia/Hypoplasia of the sacrum (HP:0008517)1.92623344
118Preauricular skin tag (HP:0000384)1.91931685
119* Tracheoesophageal fistula (HP:0002575)1.90887257
120Broad alveolar ridges (HP:0000187)1.89801647
121Horseshoe kidney (HP:0000085)1.89181682
122Sandal gap (HP:0001852)1.88477053
123Skin tags (HP:0010609)1.88447674
124Impulsivity (HP:0100710)1.86983790
125Facial cleft (HP:0002006)1.86530892
126Impaired vibration sensation in the lower limbs (HP:0002166)1.85782991
127Abnormality of the salivary glands (HP:0010286)1.85692213
128Optic nerve coloboma (HP:0000588)1.85686418
129Triphalangeal thumb (HP:0001199)1.85353983
130Poor suck (HP:0002033)1.84244267
131Cerebral hypomyelination (HP:0006808)1.83807297
132Sex reversal (HP:0012245)1.82354548
133Abnormal sex determination (HP:0012244)1.82354548
134Growth hormone deficiency (HP:0000824)1.81332016
135Short phalanx of the thumb (HP:0009660)1.80030899
136Broad palm (HP:0001169)1.79999903
137Vertebral fusion (HP:0002948)1.79479530
138Limb dystonia (HP:0002451)1.79412682
139* Esophageal atresia (HP:0002032)1.79406582
140Photophobia (HP:0000613)1.72763768
141Abnormality of the aortic arch (HP:0012303)1.71616250
142Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.64515828
143Thyroid carcinoma (HP:0002890)1.63109703
144Horizontal nystagmus (HP:0000666)1.62167796
145Microvesicular hepatic steatosis (HP:0001414)1.61532888
146Generalized hypotonia (HP:0001290)1.60674085
147* Facial asymmetry (HP:0000324)1.60573889
148Bifid tongue (HP:0010297)1.60277430
149Abnormality of the carotid arteries (HP:0005344)1.56653931
150Cutaneous finger syndactyly (HP:0010554)1.53867464
151Malignant neoplasm of the central nervous system (HP:0100836)1.53631943
152Limb hypertonia (HP:0002509)1.53443965
153Diastasis recti (HP:0001540)1.52384357
154Turricephaly (HP:0000262)1.50789256
155* Abnormality of the duodenum (HP:0002246)1.49466364
156Abnormality of the 4th metacarpal (HP:0010012)1.49104610
157Cutaneous syndactyly (HP:0012725)1.48602306
158Anophthalmia (HP:0000528)1.48140683
159Hepatoblastoma (HP:0002884)1.46048203
160Midline defect of the nose (HP:0004122)1.44967729
161Increased hepatocellular lipid droplets (HP:0006565)1.43760393
162Myokymia (HP:0002411)1.43545388
163Duplication of thumb phalanx (HP:0009942)1.43295096

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.10921273
2PBK4.02643784
3CDC73.89220134
4TIE13.48195409
5BUB13.36739360
6ZAK3.31837514
7TGFBR12.88666261
8MKNK12.84054640
9TSSK62.67157981
10CDK122.67029379
11RPS6KB22.43102261
12NTRK12.42613341
13SRPK12.40866994
14EEF2K2.36271385
15NEK22.32468725
16PASK2.21589468
17ACVR1B2.17913133
18CDK72.12096616
19DYRK32.08007082
20MKNK22.03284385
21TAF11.97349051
22TTK1.94310592
23EPHA21.82014437
24NEK11.81359996
25PLK11.76636048
26ATR1.67536227
27MAP3K101.66197816
28FLT31.65979359
29VRK11.63568284
30PKN21.63242154
31STK161.61783634
32CHEK21.54228835
33PLK31.36619711
34CDK41.34230875
35NME11.28648252
36AURKB1.28192856
37PAK41.27343698
38BRD41.25419705
39NME21.19403206
40CHEK11.19245692
41MATK1.18407653
42CDK81.14238107
43VRK21.12994424
44BRSK21.12730717
45EIF2AK11.12247752
46AURKA1.12197615
47MAP3K81.07365787
48TESK21.06326362
49INSRR1.02531785
50ALK1.01167284
51SCYL21.00136777
52NTRK21.00024215
53AKT30.97140528
54ICK0.94746406
55LATS20.93761958
56CDK60.92968764
57* CDK20.90939884
58CSNK1G10.90361979
59CLK10.89751364
60MAP3K40.89741584
61ATM0.89233500
62DYRK20.88981631
63AKT20.88034445
64MAPKAPK50.84797670
65STK100.83495661
66PLK40.83448795
67TLK10.78576538
68CDK30.76695465
69CSNK1G20.76637292
70PIM10.75642398
71KDR0.75527291
72PRKCI0.74787338
73CSNK1G30.73363797
74CASK0.72727022
75YES10.72643191
76DYRK1B0.71641792
77MAPKAPK30.69423571
78PNCK0.67341388
79GRK10.66771738
80TNIK0.66648262
81FGFR20.65064279
82CAMKK20.64585265
83* CSNK2A20.64390895
84RPS6KA40.64374879
85TYRO30.64339017
86MAP3K110.63536718
87* CSNK2A10.60570471
88STK40.60136272
89TGFBR20.59845356
90CDK10.59822060
91CDK190.59288916
92ERBB40.59101544
93DAPK10.58955578
94MAP2K60.58863888
95MAP4K20.58827755
96* MTOR0.55734917
97WNK30.51529923
98CSNK1A1L0.51294312
99CSNK1E0.49607701
100NUAK10.48478457
101PDGFRA0.48373458
102DDR20.47747433
103EIF2AK30.46368069
104DYRK1A0.45400156
105CDK11A0.45024826
106CAMK1G0.43561241
107EIF2AK20.43438905
108CDK150.42077374
109UHMK10.40127613
110MAP2K30.38845822
111BTK0.38771951
112CDK180.38727514
113BRSK10.38456808
114PRKCE0.38441238
115TAOK20.38154782
116CCNB10.37150706
117CAMKK10.36949209
118CSNK1D0.36864865
119ADRBK20.36088732
120PAK10.35567646
121PKN10.35006289
122LRRK20.33990313
123RPS6KA50.33337563
124BCKDK0.33307235
125FGFR10.32006531
126AKT10.31588800
127PRKDC0.29992532
128* MAPK140.29092635
129RPS6KB10.28970090
130* MAPK10.27888577
131MAP2K20.27630658
132RPS6KL10.27283135
133RPS6KC10.27283135
134RPS6KA10.25868302
135* GSK3B0.24534027
136RPS6KA60.24177256
137MAPK90.24096127
138MAP3K60.23713594
139BMX0.22551276
140PINK10.22312718

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.83370450
2Mismatch repair_Homo sapiens_hsa034304.75674977
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.74264275
4Ribosome_Homo sapiens_hsa030103.74249178
5Spliceosome_Homo sapiens_hsa030403.64328919
6Base excision repair_Homo sapiens_hsa034103.31761430
7RNA transport_Homo sapiens_hsa030133.25316404
8RNA polymerase_Homo sapiens_hsa030202.94578508
9One carbon pool by folate_Homo sapiens_hsa006702.79372474
10Nucleotide excision repair_Homo sapiens_hsa034202.77448666
11Homologous recombination_Homo sapiens_hsa034402.77177880
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.65427005
13Cell cycle_Homo sapiens_hsa041102.65211597
14Pyrimidine metabolism_Homo sapiens_hsa002402.31568886
15RNA degradation_Homo sapiens_hsa030182.27636968
16Fanconi anemia pathway_Homo sapiens_hsa034602.14462562
17mRNA surveillance pathway_Homo sapiens_hsa030152.04403903
18Basal transcription factors_Homo sapiens_hsa030221.93281166
19Proteasome_Homo sapiens_hsa030501.92478616
20Non-homologous end-joining_Homo sapiens_hsa034501.67693204
21p53 signaling pathway_Homo sapiens_hsa041151.59074458
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.48911312
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.43288733
24Phototransduction_Homo sapiens_hsa047441.40996828
25Taste transduction_Homo sapiens_hsa047421.34131697
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.26656711
27Basal cell carcinoma_Homo sapiens_hsa052171.25041101
28Cholinergic synapse_Homo sapiens_hsa047251.21405381
29Notch signaling pathway_Homo sapiens_hsa043301.20900266
30Nicotine addiction_Homo sapiens_hsa050331.20430581
31Purine metabolism_Homo sapiens_hsa002301.18618933
32Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.12233899
33Pyruvate metabolism_Homo sapiens_hsa006201.05556867
34Biosynthesis of amino acids_Homo sapiens_hsa012301.01695216
35Oocyte meiosis_Homo sapiens_hsa041141.01279761
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01203871
37Thyroid cancer_Homo sapiens_hsa052161.00694575
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.00463570
39Selenocompound metabolism_Homo sapiens_hsa004500.99506225
40Steroid biosynthesis_Homo sapiens_hsa001000.98230280
41Epstein-Barr virus infection_Homo sapiens_hsa051690.95195444
42* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92512367
43Systemic lupus erythematosus_Homo sapiens_hsa053220.90427647
44Viral carcinogenesis_Homo sapiens_hsa052030.90418362
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89572286
46Hippo signaling pathway_Homo sapiens_hsa043900.87459021
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85660086
48Hedgehog signaling pathway_Homo sapiens_hsa043400.85050213
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82580218
50Herpes simplex infection_Homo sapiens_hsa051680.82333743
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82160551
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81911807
53Colorectal cancer_Homo sapiens_hsa052100.79550986
54HTLV-I infection_Homo sapiens_hsa051660.79027861
55MicroRNAs in cancer_Homo sapiens_hsa052060.78796488
56Parkinsons disease_Homo sapiens_hsa050120.78773716
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.77231547
58Glutamatergic synapse_Homo sapiens_hsa047240.77026932
59Cocaine addiction_Homo sapiens_hsa050300.76279788
60Fructose and mannose metabolism_Homo sapiens_hsa000510.75970731
61TGF-beta signaling pathway_Homo sapiens_hsa043500.74176792
62Serotonergic synapse_Homo sapiens_hsa047260.72714184
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.71028606
64Dopaminergic synapse_Homo sapiens_hsa047280.71020191
65GABAergic synapse_Homo sapiens_hsa047270.68910305
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68150235
67Folate biosynthesis_Homo sapiens_hsa007900.68143054
68Morphine addiction_Homo sapiens_hsa050320.67821590
69Axon guidance_Homo sapiens_hsa043600.66949828
70Sulfur relay system_Homo sapiens_hsa041220.66780059
71Vitamin B6 metabolism_Homo sapiens_hsa007500.60982926
72Wnt signaling pathway_Homo sapiens_hsa043100.59452954
73Small cell lung cancer_Homo sapiens_hsa052220.59414350
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.58945166
75Propanoate metabolism_Homo sapiens_hsa006400.58754193
76Pathways in cancer_Homo sapiens_hsa052000.56858452
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.55899537
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55607181
79Alcoholism_Homo sapiens_hsa050340.53740053
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53722816
81Oxidative phosphorylation_Homo sapiens_hsa001900.53632570
82Bladder cancer_Homo sapiens_hsa052190.50846815
83Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49781018
84HIF-1 signaling pathway_Homo sapiens_hsa040660.49677624
85Acute myeloid leukemia_Homo sapiens_hsa052210.47519825
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47194568
87Protein export_Homo sapiens_hsa030600.46878203
88Galactose metabolism_Homo sapiens_hsa000520.46399299
89Antigen processing and presentation_Homo sapiens_hsa046120.45024489
90Chronic myeloid leukemia_Homo sapiens_hsa052200.42277676
91Cardiac muscle contraction_Homo sapiens_hsa042600.42201607
92mTOR signaling pathway_Homo sapiens_hsa041500.41977781
93Arginine and proline metabolism_Homo sapiens_hsa003300.41710348
94Circadian entrainment_Homo sapiens_hsa047130.41569223
95Amphetamine addiction_Homo sapiens_hsa050310.39452789
96Fatty acid elongation_Homo sapiens_hsa000620.38237357
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35622755
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34804054
99Metabolic pathways_Homo sapiens_hsa011000.34312401
100Fatty acid metabolism_Homo sapiens_hsa012120.33954975
101Carbon metabolism_Homo sapiens_hsa012000.33046382
102Glioma_Homo sapiens_hsa052140.32429377
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31403626
104Melanoma_Homo sapiens_hsa052180.30634902
105PI3K-Akt signaling pathway_Homo sapiens_hsa041510.29477153
106N-Glycan biosynthesis_Homo sapiens_hsa005100.29044092
107Tight junction_Homo sapiens_hsa045300.28837427
108Non-small cell lung cancer_Homo sapiens_hsa052230.27987872
109Legionellosis_Homo sapiens_hsa051340.26640049
110Adherens junction_Homo sapiens_hsa045200.26190537
111Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.25166714
112Lysine degradation_Homo sapiens_hsa003100.25061638
113Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.24956181
114Apoptosis_Homo sapiens_hsa042100.24738107
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.24525406
116Arginine biosynthesis_Homo sapiens_hsa002200.24520531
117Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.23526916
118Pentose phosphate pathway_Homo sapiens_hsa000300.23152937
119Gap junction_Homo sapiens_hsa045400.22331272
120Hepatitis B_Homo sapiens_hsa051610.22137687
121Long-term depression_Homo sapiens_hsa047300.21728811
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21420496
123Shigellosis_Homo sapiens_hsa051310.21277177
124Olfactory transduction_Homo sapiens_hsa047400.21189824
125Huntingtons disease_Homo sapiens_hsa050160.20147054
126Glutathione metabolism_Homo sapiens_hsa004800.18840190
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.17204315
128Endometrial cancer_Homo sapiens_hsa052130.16353321
129Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.14368209
130Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.13511845
131Prostate cancer_Homo sapiens_hsa052150.13012675
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.11325220
133Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.09758465
134Proteoglycans in cancer_Homo sapiens_hsa052050.09169569
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.08046382
136Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.07681406
137Rap1 signaling pathway_Homo sapiens_hsa040150.07595717
138Platelet activation_Homo sapiens_hsa046110.06931496
139Melanogenesis_Homo sapiens_hsa049160.06778655
140Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.06575482
141Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.06357552

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