MYCBP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.42940673
2regulation of B cell receptor signaling pathway (GO:0050855)5.19672690
3locomotory exploration behavior (GO:0035641)5.19145716
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.16093429
5phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.92835528
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.73138788
7ionotropic glutamate receptor signaling pathway (GO:0035235)4.60866338
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.57548650
9B cell receptor signaling pathway (GO:0050853)4.51562336
10synaptic vesicle maturation (GO:0016188)4.40873486
11regulation of glutamate receptor signaling pathway (GO:1900449)4.31113048
12cellular response to ethanol (GO:0071361)4.24620871
13vocalization behavior (GO:0071625)4.20191673
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.16103119
15positive T cell selection (GO:0043368)4.05973183
16glutamate receptor signaling pathway (GO:0007215)4.03709971
17negative T cell selection (GO:0043383)4.00602036
18negative thymic T cell selection (GO:0045060)4.00301272
19positive regulation of granulocyte differentiation (GO:0030854)3.97245896
20cerebellar Purkinje cell differentiation (GO:0021702)3.96568268
21synaptic vesicle exocytosis (GO:0016079)3.96063866
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.94266937
23regulation of gamma-delta T cell differentiation (GO:0045586)3.94091048
24regulation of gamma-delta T cell activation (GO:0046643)3.90402592
25exploration behavior (GO:0035640)3.87573039
26histone H3-K36 demethylation (GO:0070544)3.81244023
27synaptic vesicle docking involved in exocytosis (GO:0016081)3.79459533
28protein localization to synapse (GO:0035418)3.78981347
29synaptic transmission, glutamatergic (GO:0035249)3.74590102
30regulation of synaptic vesicle exocytosis (GO:2000300)3.73966808
31glutamate secretion (GO:0014047)3.65135290
32neuron cell-cell adhesion (GO:0007158)3.65054271
33nerve growth factor signaling pathway (GO:0038180)3.54949016
34positive thymic T cell selection (GO:0045059)3.50956480
35regulation of long-term neuronal synaptic plasticity (GO:0048169)3.48685754
36regulation of excitatory postsynaptic membrane potential (GO:0060079)3.47767361
37regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.46843153
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.44557139
39cellular potassium ion homeostasis (GO:0030007)3.42281621
40regulation of neuronal synaptic plasticity (GO:0048168)3.42149955
41positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.41162146
42negative regulation of T cell mediated immunity (GO:0002710)3.41031077
43neuron-neuron synaptic transmission (GO:0007270)3.40295348
44monoubiquitinated protein deubiquitination (GO:0035520)3.38839269
45regulation of synaptic vesicle transport (GO:1902803)3.37305417
46neurotransmitter secretion (GO:0007269)3.36527557
47regulation of postsynaptic membrane potential (GO:0060078)3.35167066
48long-term memory (GO:0007616)3.34978325
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.33516154
50interkinetic nuclear migration (GO:0022027)3.32700534
51layer formation in cerebral cortex (GO:0021819)3.32040887
52positive regulation of dendritic spine morphogenesis (GO:0061003)3.31265764
53neuronal action potential propagation (GO:0019227)3.30699228
54regulation of ARF protein signal transduction (GO:0032012)3.28350940
55T cell selection (GO:0045058)3.24578959
56dendritic spine morphogenesis (GO:0060997)3.23288541
57gamma-aminobutyric acid transport (GO:0015812)3.22421352
58activation of protein kinase A activity (GO:0034199)3.22360370
59proline transport (GO:0015824)3.22336054
60cellular extravasation (GO:0045123)3.20957832
61regulation of dendritic spine morphogenesis (GO:0061001)3.20687351
62microglial cell activation (GO:0001774)3.17625985
63membrane depolarization during action potential (GO:0086010)3.16054752
64peptidyl-lysine trimethylation (GO:0018023)3.16022113
65T cell migration (GO:0072678)3.15207337
66negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.12466423
67negative regulation of cell killing (GO:0031342)3.12466423
68regulation of synapse structural plasticity (GO:0051823)3.09845371
69synaptic vesicle endocytosis (GO:0048488)3.09762693
70positive regulation of Rap GTPase activity (GO:0032854)3.08942172
71activated T cell proliferation (GO:0050798)3.08647243
72dendrite morphogenesis (GO:0048813)3.08407840
73regulation of pigment cell differentiation (GO:0050932)3.07569248
74neurotransmitter-gated ion channel clustering (GO:0072578)3.06528845
75positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.05373093
76positive regulation of B cell differentiation (GO:0045579)3.04796028
77sodium ion export (GO:0071436)3.04460992
78G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.04359789
79response to interleukin-15 (GO:0070672)3.03826458
80lipid translocation (GO:0034204)3.03593479
81phospholipid translocation (GO:0045332)3.03593479
82cytoplasmic mRNA processing body assembly (GO:0033962)3.03424131
83neuron recognition (GO:0008038)3.01355411
84regulation of Rap GTPase activity (GO:0032317)3.00400068
85gamma-aminobutyric acid signaling pathway (GO:0007214)3.00105025
86B cell proliferation (GO:0042100)2.99414076
87membrane depolarization (GO:0051899)2.97916060
88regulation of synaptic transmission, glutamatergic (GO:0051966)2.97656905
89vesicle transport along microtubule (GO:0047496)2.95608408
90positive regulation of membrane potential (GO:0045838)2.95418749
91regulation of B cell differentiation (GO:0045577)2.94964172
92presynaptic membrane assembly (GO:0097105)2.94775124
93transmission of nerve impulse (GO:0019226)2.94483196
94axonal fasciculation (GO:0007413)2.91617149
95thymic T cell selection (GO:0045061)2.90429417
96cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.90417481
97regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.89537042
98prepulse inhibition (GO:0060134)2.88607303
99positive regulation of developmental pigmentation (GO:0048087)2.86678917
100response to histamine (GO:0034776)2.85319690
101peptidyl-threonine phosphorylation (GO:0018107)2.84889118
102establishment of nucleus localization (GO:0040023)2.84682407
103regulation of synaptic plasticity (GO:0048167)2.83947692
104positive regulation of synaptic transmission, GABAergic (GO:0032230)2.83148716
105nucleus localization (GO:0051647)2.82402669
106macrophage activation involved in immune response (GO:0002281)2.81594993
107regulation of vesicle fusion (GO:0031338)2.81395977
108nuclear pore complex assembly (GO:0051292)2.80030888
109neuromuscular process controlling balance (GO:0050885)2.79411411
110cellular response to interleukin-15 (GO:0071350)2.78956206
111hepatocyte apoptotic process (GO:0097284)2.78731768
112regulation of dendritic spine development (GO:0060998)2.77416038
113protein K48-linked deubiquitination (GO:0071108)2.77122981
114histone mRNA catabolic process (GO:0071044)2.76432958
115mature B cell differentiation (GO:0002335)2.75342940
116regulation of granulocyte differentiation (GO:0030852)2.74743753
117negative regulation of neurotransmitter secretion (GO:0046929)2.74618055
118innervation (GO:0060384)2.73981065
119long-term synaptic potentiation (GO:0060291)2.73968483
120regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.73485754
121negative regulation of B cell proliferation (GO:0030889)2.73319857
122regulation of neurotransmitter secretion (GO:0046928)2.72138157
123membrane hyperpolarization (GO:0060081)2.71966792
124positive regulation of synapse maturation (GO:0090129)2.71752115
125neurotransmitter transport (GO:0006836)2.71712820
126presynaptic membrane organization (GO:0097090)2.71678723
127positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.71565413
128positive regulation of dendritic spine development (GO:0060999)2.70871778
129positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.70723304
130behavioral defense response (GO:0002209)2.70351852
131behavioral fear response (GO:0001662)2.70351852
132histone H3-K4 trimethylation (GO:0080182)2.70024491
133histone H3-K4 methylation (GO:0051568)2.69680991
134negative regulation of synaptic transmission, GABAergic (GO:0032229)2.68221338
135postsynaptic membrane organization (GO:0001941)2.68058948
136response to auditory stimulus (GO:0010996)2.67213132
137B cell homeostasis (GO:0001782)2.67206978
138histone H3-K9 demethylation (GO:0033169)2.66366255
139auditory behavior (GO:0031223)2.65777076
140cell communication by electrical coupling (GO:0010644)2.65750746
141establishment of protein localization to Golgi (GO:0072600)2.63532335
142antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.62676273
143G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.62010988
144negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.61381680
145startle response (GO:0001964)2.60291509
146negative regulation of lymphocyte mediated immunity (GO:0002707)2.59997000
147organelle transport along microtubule (GO:0072384)2.59987258
148negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.59950147
149regulation of protein polyubiquitination (GO:1902914)2.59630049
150regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.59554800
151positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.58887853
152learning (GO:0007612)2.58262456
153retrograde transport, vesicle recycling within Golgi (GO:0000301)2.56605384
154cell differentiation in hindbrain (GO:0021533)2.56555892
155peptidyl-threonine modification (GO:0018210)2.56479144
156L-amino acid import (GO:0043092)2.56466557
157peptidyl-lysine methylation (GO:0018022)2.56172432
158protein targeting to Golgi (GO:0000042)2.55056155
159fear response (GO:0042596)2.53313080
160modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.53254148
161positive regulation by organism of defense response of other organism involved in symbiotic interact2.53254148
162modulation by symbiont of host immune response (GO:0052553)2.53254148
163positive regulation by symbiont of host defense response (GO:0052509)2.53254148
164modulation by symbiont of host defense response (GO:0052031)2.53254148
165modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.53254148
166regulation of neurotransmitter levels (GO:0001505)2.52974721
167glycine transport (GO:0015816)2.52699691
168suckling behavior (GO:0001967)2.52576292
169histone lysine methylation (GO:0034968)2.51191231
170antigen processing and presentation of endogenous antigen (GO:0019883)2.48629783
171histone H3-K9 modification (GO:0061647)2.48308256
172positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.47900115
173antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.47673254
174germinal center formation (GO:0002467)2.47175444
175negative regulation of neurotransmitter transport (GO:0051589)2.46976033
176corticosteroid receptor signaling pathway (GO:0031958)2.46322244
177regulation of alpha-beta T cell proliferation (GO:0046640)2.45441472
178negative regulation of erythrocyte differentiation (GO:0045647)2.43972721
179regulation of NFAT protein import into nucleus (GO:0051532)2.43944913
180macrophage activation (GO:0042116)2.43275881
181antigen receptor-mediated signaling pathway (GO:0050851)2.42641339
182regulation of histone H3-K27 methylation (GO:0061085)2.42314511
183negative regulation of adaptive immune response (GO:0002820)2.41070497
184peptidyl-serine phosphorylation (GO:0018105)2.40754662
185detection of molecule of bacterial origin (GO:0032490)2.40247827
186phosphatidylinositol phosphorylation (GO:0046854)2.40245490
187myeloid leukocyte mediated immunity (GO:0002444)2.39020815
188histone lysine demethylation (GO:0070076)2.38277553
189regulation of B cell proliferation (GO:0030888)2.37683158

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.06737105
2GBX2_23144817_ChIP-Seq_PC3_Human3.56620946
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.32913121
4DROSHA_22980978_ChIP-Seq_HELA_Human2.48063710
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.40419800
6STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.39326803
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.38974262
8GATA1_22025678_ChIP-Seq_K562_Human2.38272368
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.34087622
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.13783810
11FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.13491718
12REST_21632747_ChIP-Seq_MESCs_Mouse2.10844788
13SCL_19346495_ChIP-Seq_HPC-7_Human2.10338981
14* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.08641400
15RARB_27405468_Chip-Seq_BRAIN_Mouse2.05882374
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.05618210
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.04531563
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.03974021
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.03974021
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.03759726
21* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.97203802
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.93902150
23AR_21572438_ChIP-Seq_LNCaP_Human1.92126381
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.91054602
25JARID2_20075857_ChIP-Seq_MESCs_Mouse1.88654524
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88290400
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.87727305
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.81664983
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.81438662
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.80864168
31* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.79656591
32SMAD4_21799915_ChIP-Seq_A2780_Human1.77191577
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.75046575
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.74911937
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.73956224
36IRF8_27001747_Chip-Seq_BMDM_Mouse1.70793932
37SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.70749451
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.68673601
39TAF15_26573619_Chip-Seq_HEK293_Human1.66138933
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65749188
41Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.65391112
42* MYB_26560356_Chip-Seq_TH2_Human1.64328766
43EZH2_27294783_Chip-Seq_ESCs_Mouse1.63433323
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62462527
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.61224275
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.60318705
47MYB_21317192_ChIP-Seq_ERMYB_Mouse1.57607788
48BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.57452960
49ZFP57_27257070_Chip-Seq_ESCs_Mouse1.53109641
50TP53_16413492_ChIP-PET_HCT116_Human1.52987044
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51533783
52CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.51064151
53REST_18959480_ChIP-ChIP_MESCs_Mouse1.51011184
54IRF8_21731497_ChIP-ChIP_J774_Mouse1.50494581
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48770137
56STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.48338607
57STAT3_23295773_ChIP-Seq_U87_Human1.48211145
58VDR_24787735_ChIP-Seq_THP-1_Human1.45974381
59IGF1R_20145208_ChIP-Seq_DFB_Human1.45788133
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.44613021
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41950496
62NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.41428234
63P300_19829295_ChIP-Seq_ESCs_Human1.40685526
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40601298
65RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.40540196
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.39458297
67SOX2_21211035_ChIP-Seq_LN229_Gbm1.37319341
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.36613859
69* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35781585
70TCF4_23295773_ChIP-Seq_U87_Human1.34468079
71AHR_22903824_ChIP-Seq_MCF-7_Human1.34263289
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.32645088
73* MYB_26560356_Chip-Seq_TH1_Human1.32092473
74IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.31137616
75AR_25329375_ChIP-Seq_VCAP_Human1.30390499
76* AR_19668381_ChIP-Seq_PC3_Human1.30110027
77POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28712969
78FLI1_27457419_Chip-Seq_LIVER_Mouse1.28593302
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28570802
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27878795
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27878795
82GATA3_27048872_Chip-Seq_THYMUS_Human1.26710287
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.23548304
84SPI1_23127762_ChIP-Seq_K562_Human1.23196172
85* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23042287
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22579123
87GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22578343
88CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22206795
89WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22203282
90PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19493316
91MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17824988
92* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16391357
93* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15927628
94* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14324366
95FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.13574352
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12848298
97NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.11939864
98YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11755960
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10384597
100ZNF274_21170338_ChIP-Seq_K562_Hela1.09922530
101TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09559424
102CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08831502
103FLI1_21867929_ChIP-Seq_TH2_Mouse1.08788715
104STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07965374
105* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.07763618
106SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06031618
107RXR_22108803_ChIP-Seq_LS180_Human1.04956662
108P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04549676
109* MYC_22102868_ChIP-Seq_BL_Human1.04195614
110ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03833990
111RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03798097
112TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03257766
113* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02562217
114NANOG_18555785_Chip-Seq_ESCs_Mouse1.02328437
115KDM2B_26808549_Chip-Seq_REH_Human1.02185688
116RUNX_20019798_ChIP-Seq_JUKART_Human1.01804032
117RUNX2_22187159_ChIP-Seq_PCA_Human1.01470799
118BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01429387
119PRDM14_20953172_ChIP-Seq_ESCs_Human1.01276639
120MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01258994
121GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00620934
122E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99722020
123SMRT_27268052_Chip-Seq_Bcells_Human0.99262679
124PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99082802
125ER_23166858_ChIP-Seq_MCF-7_Human0.98769306
126SMAD3_21741376_ChIP-Seq_ESCs_Human0.98585887
127NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98268602
128CMYC_18555785_Chip-Seq_ESCs_Mouse0.97975017
129SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97780585
130SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97073774
131KDM2B_26808549_Chip-Seq_K562_Human0.96957575
132GATA1_19941827_ChIP-Seq_MEL_Mouse0.96641142
133DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95671033
134PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95305284
135* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.95115615
136WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95109266
137PU_27001747_Chip-Seq_BMDM_Mouse0.94941231
138SMAD3_21741376_ChIP-Seq_HESCs_Human0.94759611
139SMAD4_21741376_ChIP-Seq_HESCs_Human0.94601604
140RING1B_27294783_Chip-Seq_ESCs_Mouse0.92656886
141FUS_26573619_Chip-Seq_HEK293_Human0.92459412
142* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92318831
143GATA2_21666600_ChIP-Seq_HMVEC_Human0.92277752
144PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91650220
145GATA3_26560356_Chip-Seq_TH2_Human0.91581473
146UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91531486
147P53_22387025_ChIP-Seq_ESCs_Mouse0.91308406
148E2F1_18555785_Chip-Seq_ESCs_Mouse0.90990102
149RNF2_27304074_Chip-Seq_NSC_Mouse0.90325312
150EZH2_27294783_Chip-Seq_NPCs_Mouse0.90024523

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.44269487
2MP0008057_abnormal_DNA_replication4.96315947
3MP0003880_abnormal_central_pattern4.15827700
4MP0000569_abnormal_digit_pigmentation4.14016021
5MP0003635_abnormal_synaptic_transmissio3.87785251
6MP0003763_abnormal_thymus_physiology3.54743078
7MP0009745_abnormal_behavioral_response3.18456923
8MP0004270_analgesia3.10096285
9MP0002063_abnormal_learning/memory/cond3.02728922
10MP0009046_muscle_twitch2.96098456
11MP0001835_abnormal_antigen_presentation2.93515907
12MP0002064_seizures2.80404745
13MP0001968_abnormal_touch/_nociception2.78439012
14MP0005423_abnormal_somatic_nervous2.62562078
15MP0003787_abnormal_imprinting2.60346674
16MP0002572_abnormal_emotion/affect_behav2.59149417
17MP0001486_abnormal_startle_reflex2.39962301
18MP0002396_abnormal_hematopoietic_system2.38993080
19MP0002735_abnormal_chemical_nociception2.37493448
20MP0001501_abnormal_sleep_pattern2.35560691
21MP0002272_abnormal_nervous_system2.28556101
22MP0001800_abnormal_humoral_immune2.25408968
23MP0004381_abnormal_hair_follicle2.24155451
24MP0002734_abnormal_mechanical_nocicepti2.17408471
25MP0008569_lethality_at_weaning2.05947788
26MP0002736_abnormal_nociception_after2.02261422
27MP0002067_abnormal_sensory_capabilities1.97074264
28MP0001440_abnormal_grooming_behavior1.93442901
29MP0000685_abnormal_immune_system1.87645585
30MP0009780_abnormal_chondrocyte_physiolo1.84960940
31MP0002909_abnormal_adrenal_gland1.75940273
32MP0005671_abnormal_response_to1.73869980
33MP0002822_catalepsy1.73162718
34MP0002733_abnormal_thermal_nociception1.72409621
35MP0002398_abnormal_bone_marrow1.67393429
36MP0002006_tumorigenesis1.66279533
37MP0001970_abnormal_pain_threshold1.65573479
38MP0005386_behavior/neurological_phenoty1.64079769
39MP0004924_abnormal_behavior1.64079769
40MP0004808_abnormal_hematopoietic_stem1.63752610
41MP0002557_abnormal_social/conspecific_i1.61823441
42MP0004811_abnormal_neuron_physiology1.60256116
43* MP0000778_abnormal_nervous_system1.59242005
44MP0002420_abnormal_adaptive_immunity1.58570255
45MP0004510_myositis1.57419489
46MP0003045_fibrosis1.56347104
47* MP0002184_abnormal_innervation1.56121530
48MP0000703_abnormal_thymus_morphology1.54355186
49MP0005000_abnormal_immune_tolerance1.53752131
50MP0001819_abnormal_immune_cell1.53450769
51MP0005645_abnormal_hypothalamus_physiol1.52845167
52MP0005387_immune_system_phenotype1.52793233
53MP0001790_abnormal_immune_system1.52793233
54MP0002723_abnormal_immune_serum1.52572915
55MP0002452_abnormal_antigen_presenting1.49260633
56MP0001188_hyperpigmentation1.43409410
57MP0005646_abnormal_pituitary_gland1.43023566
58MP0000716_abnormal_immune_system1.39094974
59MP0003633_abnormal_nervous_system1.36180179
60MP0008961_abnormal_basal_metabolism1.35289906
61MP0001502_abnormal_circadian_rhythm1.35214705
62MP0001984_abnormal_olfaction1.32210548
63MP0003091_abnormal_cell_migration1.29514575
64MP0003724_increased_susceptibility_to1.28768359
65MP0004858_abnormal_nervous_system1.28343997
66* MP0000955_abnormal_spinal_cord1.27105205
67MP0008877_abnormal_DNA_methylation1.25098868
68* MP0002882_abnormal_neuron_morphology1.23776897
69MP0004885_abnormal_endolymph1.23754989
70MP0003879_abnormal_hair_cell1.23433828
71MP0003866_abnormal_defecation1.23028586
72MP0006276_abnormal_autonomic_nervous1.22742988
73MP0000689_abnormal_spleen_morphology1.21388056
74MP0010352_gastrointestinal_tract_polyps1.18870580
75* MP0002066_abnormal_motor_capabilities/c1.18812686
76MP0002419_abnormal_innate_immunity1.18112021
77MP0002722_abnormal_immune_system1.17880328
78MP0003183_abnormal_peptide_metabolism1.17200215
79MP0003828_pulmonary_edema1.16812239
80MP0002405_respiratory_system_inflammati1.16535879
81MP0005075_abnormal_melanosome_morpholog1.14773696
82MP0005174_abnormal_tail_pigmentation1.13980283
83MP0008260_abnormal_autophagy1.12138482
84MP0005025_abnormal_response_to1.11509263
85MP0005409_darkened_coat_color1.09210548
86MP0003172_abnormal_lysosome_physiology1.08617017
87MP0001851_eye_inflammation1.08553364
88MP0005464_abnormal_platelet_physiology1.07129288
89MP0003122_maternal_imprinting1.07128318
90MP0000015_abnormal_ear_pigmentation1.05219582
91MP0004947_skin_inflammation1.04805191
92MP0004145_abnormal_muscle_electrophysio1.04426960
93MP0003436_decreased_susceptibility_to1.03331173
94* MP0003631_nervous_system_phenotype1.03033347
95MP0003690_abnormal_glial_cell1.00185564
96MP0002429_abnormal_blood_cell0.99945110
97MP0004742_abnormal_vestibular_system0.98426227
98* MP0002152_abnormal_brain_morphology0.97522742
99MP0009115_abnormal_fat_cell0.93457378
100MP0000371_diluted_coat_color0.92453696
101MP0000465_gastrointestinal_hemorrhage0.90896262
102MP0002229_neurodegeneration0.90421438
103MP0003868_abnormal_feces_composition0.90255140
104MP0005551_abnormal_eye_electrophysiolog0.88593454
105MP0003329_amyloid_beta_deposits0.87843720
106MP0008874_decreased_physiological_sensi0.84800436
107MP0001177_atelectasis0.82105519
108MP0004883_abnormal_blood_vessel0.81290017
109MP0004142_abnormal_muscle_tone0.80429666
110MP0002332_abnormal_exercise_endurance0.79759358
111MP0005076_abnormal_cell_differentiation0.79601681
112MP0002069_abnormal_eating/drinking_beha0.78908458
113MP0002090_abnormal_vision0.78854404
114MP0001299_abnormal_eye_distance/0.78828289
115MP0004130_abnormal_muscle_cell0.78734077
116MP0005621_abnormal_cell_physiology0.77899891
117MP0003121_genomic_imprinting0.77436202
118MP0010386_abnormal_urinary_bladder0.73337096
119MP0000427_abnormal_hair_cycle0.72566669
120MP0000604_amyloidosis0.72183178
121MP0004484_altered_response_of0.71582650
122MP0003303_peritoneal_inflammation0.71166347
123MP0001986_abnormal_taste_sensitivity0.69212550
124MP0002095_abnormal_skin_pigmentation0.68929300
125MP0002998_abnormal_bone_remodeling0.68315287
126MP0002876_abnormal_thyroid_physiology0.67769847
127MP0003634_abnormal_glial_cell0.67591259
128MP0005397_hematopoietic_system_phenotyp0.67420281
129MP0001545_abnormal_hematopoietic_system0.67420281
130MP0005535_abnormal_body_temperature0.67310452
131MP0003656_abnormal_erythrocyte_physiolo0.66868942
132MP0004134_abnormal_chest_morphology0.66093856
133MP0000751_myopathy0.65569604
134MP0008872_abnormal_physiological_respon0.65383016
135MP0010155_abnormal_intestine_physiology0.63002422
136* MP0003632_abnormal_nervous_system0.62568633
137MP0000920_abnormal_myelination0.62374433
138MP0004085_abnormal_heartbeat0.61990256
139MP0005310_abnormal_salivary_gland0.61989415
140MP0001963_abnormal_hearing_physiology0.58493768
141MP0001905_abnormal_dopamine_level0.57086790
142MP0002166_altered_tumor_susceptibility0.56222077
143MP0010769_abnormal_survival0.54865604
144MP0000631_abnormal_neuroendocrine_gland0.54753088
145MP0002082_postnatal_lethality0.52772662
146MP0010770_preweaning_lethality0.52772662
147MP0010768_mortality/aging0.51920950
148MP0010234_abnormal_vibrissa_follicle0.50808250
149* MP0002752_abnormal_somatic_nervous0.50724602
150MP0000013_abnormal_adipose_tissue0.50440586
151MP0004215_abnormal_myocardial_fiber0.47905669
152MP0002009_preneoplasia0.47298168
153MP0003300_gastrointestinal_ulcer0.47187252
154MP0005670_abnormal_white_adipose0.46701555
155MP0003075_altered_response_to0.46654696

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.08718267
2Focal seizures (HP:0007359)4.84926797
3Febrile seizures (HP:0002373)4.39686916
4Myokymia (HP:0002411)4.27394254
5T lymphocytopenia (HP:0005403)4.16670780
6Visual hallucinations (HP:0002367)4.00561597
7Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.86592314
8Progressive cerebellar ataxia (HP:0002073)3.85428103
9Abnormality of T cell number (HP:0011839)3.82826203
10Epileptic encephalopathy (HP:0200134)3.62570870
11Action tremor (HP:0002345)3.58579428
12Atonic seizures (HP:0010819)3.49973178
13Broad-based gait (HP:0002136)3.44240212
14Gaze-evoked nystagmus (HP:0000640)3.40984182
15Papillary thyroid carcinoma (HP:0002895)3.29788129
16Absence seizures (HP:0002121)3.13203501
17Colitis (HP:0002583)3.10388022
18Genetic anticipation (HP:0003743)3.09265654
19Recurrent viral infections (HP:0004429)3.03656704
20Supranuclear gaze palsy (HP:0000605)2.97967848
21Truncal ataxia (HP:0002078)2.96549198
22Recurrent bacterial skin infections (HP:0005406)2.96492717
23Postural instability (HP:0002172)2.94934453
24Dialeptic seizures (HP:0011146)2.93439843
25Macroorchidism (HP:0000053)2.89545115
26Abnormal delayed hypersensitivity skin test (HP:0002963)2.86980974
27Urinary bladder sphincter dysfunction (HP:0002839)2.84712834
28Dysdiadochokinesis (HP:0002075)2.83626010
29Generalized tonic-clonic seizures (HP:0002069)2.81533766
30Recurrent fungal infections (HP:0002841)2.80232090
31Eczematoid dermatitis (HP:0000976)2.79808291
32Excessive salivation (HP:0003781)2.77959926
33Drooling (HP:0002307)2.77959926
34Hemiplegia (HP:0002301)2.76246135
35Impaired smooth pursuit (HP:0007772)2.76242285
36Subacute progressive viral hepatitis (HP:0006572)2.72358990
37Poor eye contact (HP:0000817)2.71454650
38Recurrent cutaneous fungal infections (HP:0011370)2.70817840
39Chronic mucocutaneous candidiasis (HP:0002728)2.70817840
40Acute myeloid leukemia (HP:0004808)2.68017786
41Progressive inability to walk (HP:0002505)2.65966094
42Agammaglobulinemia (HP:0004432)2.65243781
43Papilledema (HP:0001085)2.64868592
44Viral hepatitis (HP:0006562)2.63867286
45Spontaneous hematomas (HP:0007420)2.60321161
46Dysmetria (HP:0001310)2.59862586
47Abnormal social behavior (HP:0012433)2.58093490
48Impaired social interactions (HP:0000735)2.58093490
49Impaired vibration sensation in the lower limbs (HP:0002166)2.57773419
50Hypoplasia of the thymus (HP:0000778)2.57307250
51Panhypogammaglobulinemia (HP:0003139)2.55277283
52Recurrent bronchitis (HP:0002837)2.52077276
53Abnormality of ocular smooth pursuit (HP:0000617)2.51855612
54Depression (HP:0000716)2.50079724
55Scanning speech (HP:0002168)2.49160882
56Abnormality of binocular vision (HP:0011514)2.47901335
57Diplopia (HP:0000651)2.47901335
58Inappropriate behavior (HP:0000719)2.45651843
59Autoimmune hemolytic anemia (HP:0001890)2.43494998
60Truncal obesity (HP:0001956)2.41940763
61Thyroiditis (HP:0100646)2.41804137
62Abnormality of T cells (HP:0002843)2.41444231
63Inflammation of the large intestine (HP:0002037)2.39745727
64Dysmetric saccades (HP:0000641)2.39224901
65Exotropia (HP:0000577)2.37325008
66Intention tremor (HP:0002080)2.36816927
67IgA deficiency (HP:0002720)2.36686626
68Slow saccadic eye movements (HP:0000514)2.35484926
69Recurrent abscess formation (HP:0002722)2.34996600
70Ankle clonus (HP:0011448)2.32850912
71Prominent nose (HP:0000448)2.32085100
72Absent speech (HP:0001344)2.31033997
73Abnormality of the fingertips (HP:0001211)2.28856140
74Meningitis (HP:0001287)2.28659534
75Overgrowth (HP:0001548)2.28583299
76Lower limb amyotrophy (HP:0007210)2.27475767
77Protruding tongue (HP:0010808)2.27139617
78Urinary urgency (HP:0000012)2.25012784
79Mutism (HP:0002300)2.24823842
80Aqueductal stenosis (HP:0002410)2.24271305
81Gastrointestinal inflammation (HP:0004386)2.22936354
82Recurrent skin infections (HP:0001581)2.22489401
83Submucous cleft hard palate (HP:0000176)2.22434619
84Conjunctival telangiectasia (HP:0000524)2.22379917
85Gingivitis (HP:0000230)2.20398628
86Stereotypic behavior (HP:0000733)2.20035925
87Hemiparesis (HP:0001269)2.15310902
88Hyperventilation (HP:0002883)2.14975101
89Volvulus (HP:0002580)2.13242121
90Widely spaced teeth (HP:0000687)2.13181565
91Cellulitis (HP:0100658)2.11702800
92Open mouth (HP:0000194)2.08042925
93Abnormal eating behavior (HP:0100738)2.07807201
94Chest pain (HP:0100749)2.06362357
95Spastic gait (HP:0002064)2.06250355
96Vasculitis (HP:0002633)2.04198098
97Short chin (HP:0000331)2.04088102
98Narrow palate (HP:0000189)2.04083837
99Neonatal hypoglycemia (HP:0001998)2.03798411
100Bundle branch block (HP:0011710)2.02667844
101Bradykinesia (HP:0002067)2.02476091
102Amblyopia (HP:0000646)1.99357402
103Menstrual irregularities (HP:0000858)1.99330968
104Pointed chin (HP:0000307)1.98393455
105Sandal gap (HP:0001852)1.97864645
106Tapered finger (HP:0001182)1.97592404
107Lower limb asymmetry (HP:0100559)1.96265055
108IgM deficiency (HP:0002850)1.95627438
109Abnormality of the vasculature of the conjunctiva (HP:0008054)1.95357602
110Inability to walk (HP:0002540)1.94406205
111Abnormality of the lower motor neuron (HP:0002366)1.93387043
112Generalized hypopigmentation of hair (HP:0011358)1.92765874
113Abnormality of the corticospinal tract (HP:0002492)1.92319903
114Acute lymphatic leukemia (HP:0006721)1.91245536
115Lymphopenia (HP:0001888)1.90494447
116Abnormality of salivation (HP:0100755)1.90228364
117Agitation (HP:0000713)1.89372735
118Mediastinal lymphadenopathy (HP:0100721)1.88452553
119Blue irides (HP:0000635)1.87269694
120Thyroid carcinoma (HP:0002890)1.86707413
121Anxiety (HP:0000739)1.85904703
122Gingival bleeding (HP:0000225)1.85706027
123Verrucae (HP:0200043)1.85446109
124Papilloma (HP:0012740)1.85446109
125Absent frontal sinuses (HP:0002688)1.85141920
126Gastrointestinal infarctions (HP:0005244)1.85042952
127Neoplasm of the tracheobronchial system (HP:0100552)1.84192217
128Eosinophilia (HP:0001880)1.82709994
129Termporal pattern (HP:0011008)1.81955190
130Insidious onset (HP:0003587)1.81955190
131Obsessive-compulsive behavior (HP:0000722)1.79802474
132Obstructive sleep apnea (HP:0002870)1.79710174
133Lower limb muscle weakness (HP:0007340)1.79619215
134Deeply set eye (HP:0000490)1.78625162
135Leukocytosis (HP:0001974)1.78037333
136Difficulty running (HP:0009046)1.76759314
137Abnormality of cells of the lymphoid lineage (HP:0012140)1.76686258
138Increased IgE level (HP:0003212)1.76598767
139Thoracolumbar scoliosis (HP:0002944)1.76341492
140Severe combined immunodeficiency (HP:0004430)1.76246362
141Epileptiform EEG discharges (HP:0011182)1.75398386
142Hyperkalemia (HP:0002153)1.75234013
143Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.74962903
144Degeneration of the lateral corticospinal tracts (HP:0002314)1.74962903
145Impaired vibratory sensation (HP:0002495)1.74278913
146Mask-like facies (HP:0000298)1.68667262
147Abnormality of saccadic eye movements (HP:0000570)1.68312457
148Amyotrophic lateral sclerosis (HP:0007354)1.67856239
149Buphthalmos (HP:0000557)1.66074082
150EEG with generalized epileptiform discharges (HP:0011198)1.65018526
151Abnormal hair whorl (HP:0010721)1.64640050
152Annular pancreas (HP:0001734)1.64145015
153Fair hair (HP:0002286)1.61339984
154Hypoplasia of the brainstem (HP:0002365)1.61278009
155Aplasia/Hypoplasia of the brainstem (HP:0007362)1.61278009
156Gait ataxia (HP:0002066)1.59935721
157Neuronal loss in central nervous system (HP:0002529)1.59239353
158Psychosis (HP:0000709)1.58977700
159Hyperacusis (HP:0010780)1.58113536
160Type II lissencephaly (HP:0007260)1.57223853
161Autism (HP:0000717)1.56259120
162Insomnia (HP:0100785)1.54624654
163Macroglossia (HP:0000158)1.54452838
164Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.53125460
165Heterotopia (HP:0002282)1.52895408
166Abnormal EKG (HP:0003115)1.51703352

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.51029941
2EPHA43.14421992
3MAP3K92.86864941
4MARK12.79744538
5MAP3K42.74662944
6RIPK42.36370858
7NTRK22.22923976
8SIK22.15237378
9CAMK1G2.15121881
10PRPF4B1.96919125
11BLK1.96071974
12TNIK1.94608132
13AKT31.93460494
14MAP2K71.92859880
15MAP4K11.91389017
16MINK11.79177235
17CAMKK11.72500002
18MAP3K131.70829231
19DAPK21.69320730
20MAPK131.60643132
21PAK61.59563743
22TAOK31.59249900
23NLK1.58100137
24BRD41.55756058
25CAMK1D1.55512527
26BTK1.54064568
27TEC1.53922282
28SGK21.48765334
29CAMKK21.47328524
30MAP2K41.44585419
31MAP3K101.43090289
32FES1.41586942
33TYK21.40259317
34SGK31.36632902
35IKBKE1.34248776
36BMPR21.33869112
37CDK51.28526300
38STK381.27701775
39TRPM71.26391986
40JAK31.22293369
41PNCK1.19563252
42PRKCH1.17964072
43TXK1.17566614
44ITK1.17535825
45CASK1.16703392
46PRKD31.16174691
47MARK21.14882479
48STK111.11347471
49NTRK11.10386965
50SGK4941.07454321
51SGK2231.07454321
52MAP3K121.07446225
53TNK21.07062915
54KSR11.06795950
55KSR21.06699563
56SGK11.05021219
57EEF2K1.03618205
58MELK1.02704884
59WNK11.01780854
60CSK0.99366236
61KIT0.99187123
62MAP3K20.99119641
63RET0.98325575
64DAPK10.97870925
65JAK10.97422652
66TAOK10.96465075
67CDC42BPA0.92320213
68JAK20.91215733
69PRKD20.90653385
70CAMK10.87420354
71MAPK110.85448936
72RIPK10.85329374
73LCK0.83331955
74FGFR30.83166901
75TYRO30.82382037
76PRKCG0.79984677
77PHKG20.79959868
78PHKG10.79959868
79CDK60.78835785
80FGFR20.77375443
81PDK10.75336256
82NEK60.74267286
83FGFR40.74152107
84CAMK2A0.72802419
85GRK60.72018261
86MAPK70.71160505
87EPHA30.70572111
88LYN0.70317863
89MAP3K70.69885287
90ALK0.69716454
91PLK20.67445346
92CAMK40.67349663
93CSF1R0.66534746
94PIK3CG0.65986374
95YES10.65950660
96PIM10.65640031
97FGR0.65259766
98PDGFRB0.63937983
99GRK50.63735676
100ZAP700.61163945
101RPS6KB10.60571850
102MAP2K30.60314819
103CDK120.59908327
104PDPK10.59207497
105RPS6KA30.58743880
106HCK0.58726656
107DYRK1A0.58194493
108MAPK100.58164173
109PTK2B0.58090635
110DMPK0.56854099
111SCYL20.56809131
112CAMK2B0.55972766
113RAF10.55813374
114FYN0.55297190
115FRK0.55195630
116UHMK10.54676562
117INSRR0.53999913
118CCNB10.53866333
119NEK90.53403627
120CSNK1G20.52869577
121MAP3K60.51575994
122CDK40.51327311
123PDGFRA0.49042288
124ACVR1B0.46419910
125SYK0.46351647
126PRKCQ0.45914598
127LMTK20.45368973
128CDK30.43861243
129PRKG10.43567039
130MAPK120.42423071
131PRKCE0.41861035
132PAK30.41404303
133MAPK80.40446221
134PRKCB0.40137588
135HIPK20.39038379
136PRKCZ0.38937097
137CDK90.38591469
138PRKD10.37639158
139RPS6KA20.37589125
140MAP3K140.37356166
141PKN10.36602626

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.02405347
2Long-term potentiation_Homo sapiens_hsa047202.35694948
3Olfactory transduction_Homo sapiens_hsa047402.35099373
4Glutamatergic synapse_Homo sapiens_hsa047242.27004231
5Circadian entrainment_Homo sapiens_hsa047132.24967565
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.19311140
7Morphine addiction_Homo sapiens_hsa050322.16836385
8GABAergic synapse_Homo sapiens_hsa047271.99368848
9Synaptic vesicle cycle_Homo sapiens_hsa047211.98040312
10Amphetamine addiction_Homo sapiens_hsa050311.95860848
11Salivary secretion_Homo sapiens_hsa049701.86304476
12Aldosterone synthesis and secretion_Homo sapiens_hsa049251.75539507
13Dopaminergic synapse_Homo sapiens_hsa047281.72199492
14Renin secretion_Homo sapiens_hsa049241.70482646
15Cholinergic synapse_Homo sapiens_hsa047251.70034880
16Type II diabetes mellitus_Homo sapiens_hsa049301.69724994
17Insulin secretion_Homo sapiens_hsa049111.66423344
18Gastric acid secretion_Homo sapiens_hsa049711.59507288
19Taste transduction_Homo sapiens_hsa047421.59470641
20Phosphatidylinositol signaling system_Homo sapiens_hsa040701.56907298
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.52960186
22Oxytocin signaling pathway_Homo sapiens_hsa049211.52552886
23Primary immunodeficiency_Homo sapiens_hsa053401.51563565
24Calcium signaling pathway_Homo sapiens_hsa040201.42973222
25Long-term depression_Homo sapiens_hsa047301.42664373
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.42335951
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.39324257
28GnRH signaling pathway_Homo sapiens_hsa049121.35254547
29Serotonergic synapse_Homo sapiens_hsa047261.32625236
30Cocaine addiction_Homo sapiens_hsa050301.31275042
31cAMP signaling pathway_Homo sapiens_hsa040241.30660624
32Leishmaniasis_Homo sapiens_hsa051401.29842578
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29359570
34Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.26874420
35Measles_Homo sapiens_hsa051621.25486206
36Glioma_Homo sapiens_hsa052141.22276103
37Estrogen signaling pathway_Homo sapiens_hsa049151.21044170
38ErbB signaling pathway_Homo sapiens_hsa040121.17073351
39Dorso-ventral axis formation_Homo sapiens_hsa043201.14489359
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.14445273
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13857181
42NF-kappa B signaling pathway_Homo sapiens_hsa040641.07742396
43Toll-like receptor signaling pathway_Homo sapiens_hsa046201.05094258
44Hepatitis B_Homo sapiens_hsa051611.04943049
45Graft-versus-host disease_Homo sapiens_hsa053321.04603701
46Allograft rejection_Homo sapiens_hsa053301.03205582
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.03000741
48Axon guidance_Homo sapiens_hsa043601.02397468
49Gap junction_Homo sapiens_hsa045401.02302378
50Tuberculosis_Homo sapiens_hsa051521.01459131
51Phospholipase D signaling pathway_Homo sapiens_hsa040721.01141573
52Toxoplasmosis_Homo sapiens_hsa051451.00286166
53Autoimmune thyroid disease_Homo sapiens_hsa053200.99861590
54Choline metabolism in cancer_Homo sapiens_hsa052310.98541069
55B cell receptor signaling pathway_Homo sapiens_hsa046620.97689453
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96439286
57Influenza A_Homo sapiens_hsa051640.95240204
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.93445053
59Inositol phosphate metabolism_Homo sapiens_hsa005620.93256748
60Prostate cancer_Homo sapiens_hsa052150.92253008
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.91827911
62MAPK signaling pathway_Homo sapiens_hsa040100.91699764
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91330611
64mTOR signaling pathway_Homo sapiens_hsa041500.89103955
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88329791
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.87388189
67Intestinal immune network for IgA production_Homo sapiens_hsa046720.87238024
68NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85322727
69Pancreatic secretion_Homo sapiens_hsa049720.85295957
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85059424
71T cell receptor signaling pathway_Homo sapiens_hsa046600.85053037
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84624433
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84583581
74Chemokine signaling pathway_Homo sapiens_hsa040620.84218885
75Endometrial cancer_Homo sapiens_hsa052130.82397619
76VEGF signaling pathway_Homo sapiens_hsa043700.82093188
77Melanogenesis_Homo sapiens_hsa049160.81719677
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79440827
79Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.78878666
80Dilated cardiomyopathy_Homo sapiens_hsa054140.76632319
81Non-small cell lung cancer_Homo sapiens_hsa052230.76021369
82Hepatitis C_Homo sapiens_hsa051600.74611355
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.74159272
84Staphylococcus aureus infection_Homo sapiens_hsa051500.73088490
85MicroRNAs in cancer_Homo sapiens_hsa052060.73079776
86TNF signaling pathway_Homo sapiens_hsa046680.73069485
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72387084
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71569813
89Hematopoietic cell lineage_Homo sapiens_hsa046400.71498353
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71380552
91Rap1 signaling pathway_Homo sapiens_hsa040150.70142748
92Osteoclast differentiation_Homo sapiens_hsa043800.70023775
93Ras signaling pathway_Homo sapiens_hsa040140.69596814
94Prolactin signaling pathway_Homo sapiens_hsa049170.68065584
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67634795
96Lysine degradation_Homo sapiens_hsa003100.66100369
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65640866
98Platelet activation_Homo sapiens_hsa046110.65262804
99Phototransduction_Homo sapiens_hsa047440.65032144
100Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64981831
101Thyroid hormone synthesis_Homo sapiens_hsa049180.64919384
102Herpes simplex infection_Homo sapiens_hsa051680.64150436
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.63777843
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.62941040
105Glucagon signaling pathway_Homo sapiens_hsa049220.61910287
106Apoptosis_Homo sapiens_hsa042100.60882739
107Colorectal cancer_Homo sapiens_hsa052100.59750559
108Viral carcinogenesis_Homo sapiens_hsa052030.59471626
109Insulin signaling pathway_Homo sapiens_hsa049100.59142107
110Oocyte meiosis_Homo sapiens_hsa041140.58669727
111Renal cell carcinoma_Homo sapiens_hsa052110.58335635
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57701192
113Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57419366
114Circadian rhythm_Homo sapiens_hsa047100.55309106
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53131301
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53094317
117Endocytosis_Homo sapiens_hsa041440.52213577
118Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50727552
119Pancreatic cancer_Homo sapiens_hsa052120.50392027
120Type I diabetes mellitus_Homo sapiens_hsa049400.48093284
121Wnt signaling pathway_Homo sapiens_hsa043100.47486996
122Collecting duct acid secretion_Homo sapiens_hsa049660.46823507
123Chronic myeloid leukemia_Homo sapiens_hsa052200.45560491
124AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42434615
125Acute myeloid leukemia_Homo sapiens_hsa052210.42397512
126African trypanosomiasis_Homo sapiens_hsa051430.42038934
127Ovarian steroidogenesis_Homo sapiens_hsa049130.41732365
128FoxO signaling pathway_Homo sapiens_hsa040680.41723118
129Insulin resistance_Homo sapiens_hsa049310.41195543

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