MYBL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)9.84780821
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)9.46368311
3antigen processing and presentation of endogenous antigen (GO:0019883)8.00992227
4regulation of cytokine production involved in inflammatory response (GO:1900015)6.65411682
5somatic hypermutation of immunoglobulin genes (GO:0016446)5.41734688
6somatic diversification of immune receptors via somatic mutation (GO:0002566)5.41734688
7nuclear pore complex assembly (GO:0051292)5.14990796
8kinetochore organization (GO:0051383)5.03062945
9mitotic chromosome condensation (GO:0007076)4.81009926
10nuclear pore organization (GO:0006999)4.78001638
11sister chromatid segregation (GO:0000819)4.70660562
12mitotic sister chromatid cohesion (GO:0007064)4.66432236
13mitotic sister chromatid segregation (GO:0000070)4.59889965
14protein localization to chromosome, centromeric region (GO:0071459)4.46264375
15protein localization to kinetochore (GO:0034501)4.40093242
16mitotic metaphase plate congression (GO:0007080)4.37067442
17piRNA metabolic process (GO:0034587)4.33570197
18response to interleukin-15 (GO:0070672)4.33190202
19negative regulation of cell killing (GO:0031342)4.31753001
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.31753001
21microtubule depolymerization (GO:0007019)4.23274488
22leukocyte aggregation (GO:0070486)4.17918230
23meiotic chromosome segregation (GO:0045132)4.16520030
24kinetochore assembly (GO:0051382)4.14977031
25positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.13744712
26regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.12565882
27translesion synthesis (GO:0019985)4.08744445
28metaphase plate congression (GO:0051310)4.06524530
29protein K6-linked ubiquitination (GO:0085020)4.05327371
30maturation of SSU-rRNA (GO:0030490)4.03119595
31chromatin remodeling at centromere (GO:0031055)4.02870843
32regulation of histone H3-K9 methylation (GO:0051570)3.96806397
33cellular response to interleukin-15 (GO:0071350)3.93485503
34CENP-A containing nucleosome assembly (GO:0034080)3.93364367
35DNA replication-dependent nucleosome organization (GO:0034723)3.93239633
36DNA replication-dependent nucleosome assembly (GO:0006335)3.93239633
37pore complex assembly (GO:0046931)3.91100015
38histone exchange (GO:0043486)3.90142290
39attachment of spindle microtubules to kinetochore (GO:0008608)3.88624426
40mitotic recombination (GO:0006312)3.87732021
41regulation of centriole replication (GO:0046599)3.86311690
42sister chromatid cohesion (GO:0007062)3.85370074
43cilium or flagellum-dependent cell motility (GO:0001539)3.76757195
44DNA replication-independent nucleosome organization (GO:0034724)3.71780189
45DNA replication-independent nucleosome assembly (GO:0006336)3.71780189
46telomere maintenance via semi-conservative replication (GO:0032201)3.68120379
47regulation of B cell receptor signaling pathway (GO:0050855)3.67909215
48establishment of chromosome localization (GO:0051303)3.66881783
49telomere maintenance via recombination (GO:0000722)3.65960916
50regulation of DNA endoreduplication (GO:0032875)3.63347212
51positive regulation of transcription regulatory region DNA binding (GO:2000679)3.61884315
52regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.59757267
53DNA strand elongation involved in DNA replication (GO:0006271)3.57518676
54NIK/NF-kappaB signaling (GO:0038061)3.56069525
55DNA methylation involved in gamete generation (GO:0043046)3.53253697
56cytidine metabolic process (GO:0046087)3.52258873
57cytidine catabolic process (GO:0006216)3.52258873
58cytidine deamination (GO:0009972)3.52258873
59regulation of interleukin-12 biosynthetic process (GO:0045075)3.51361305
60negative regulation of DNA repair (GO:0045738)3.51116938
61DNA replication initiation (GO:0006270)3.51027754
62antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.49264668
63DNA unwinding involved in DNA replication (GO:0006268)3.48819851
64positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.48699259
65positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.48699259
66positive regulation of mitotic sister chromatid separation (GO:1901970)3.48699259
67chromosome condensation (GO:0030261)3.47498451
68chromosome segregation (GO:0007059)3.46160963
69DNA strand elongation (GO:0022616)3.41847485
70regulation of double-strand break repair (GO:2000779)3.41565801
71DNA packaging (GO:0006323)3.40604700
72hepatocyte apoptotic process (GO:0097284)3.40194914
73DNA synthesis involved in DNA repair (GO:0000731)3.39281139
74male meiosis (GO:0007140)3.39266579
75regulation of interleukin-6 biosynthetic process (GO:0045408)3.34322430
76resolution of meiotic recombination intermediates (GO:0000712)3.30489718
77DNA replication checkpoint (GO:0000076)3.29580568
78protein localization to chromosome (GO:0034502)3.28657183
79negative regulation of histone methylation (GO:0031061)3.28560858
80acrosome assembly (GO:0001675)3.27684969
81chromatin assembly or disassembly (GO:0006333)3.27343209
82regulation of centrosome cycle (GO:0046605)3.26989804
83mitotic nuclear envelope disassembly (GO:0007077)3.25580853
84regulation of double-strand break repair via homologous recombination (GO:0010569)3.25364668
85nucleotide-excision repair, DNA gap filling (GO:0006297)3.25252357
86postreplication repair (GO:0006301)3.24822150
87nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)3.21750655
88positive regulation of T cell cytokine production (GO:0002726)3.21586225
89regulation of fibroblast apoptotic process (GO:2000269)3.21546572
90meiotic cell cycle (GO:0051321)3.20217645
91regulation of sister chromatid cohesion (GO:0007063)3.16837738
92synaptonemal complex assembly (GO:0007130)3.16304087
93regulation of chromosome segregation (GO:0051983)3.16055592
94ATP-dependent chromatin remodeling (GO:0043044)3.16013431
95chromosome organization involved in meiosis (GO:0070192)3.15774648
96positive regulation of gamma-delta T cell activation (GO:0046645)3.15653362
97synaptonemal complex organization (GO:0070193)3.13854697
98membrane raft organization (GO:0031579)3.10597660
99positive regulation of chromosome segregation (GO:0051984)3.09741156
100intra-S DNA damage checkpoint (GO:0031573)3.08659666
101regulation of mitotic metaphase/anaphase transition (GO:0030071)3.08293545
102nuclear envelope disassembly (GO:0051081)3.07427917
103membrane disassembly (GO:0030397)3.07427917
104negative regulation of DNA-dependent DNA replication (GO:2000104)3.06267340
105meiotic nuclear division (GO:0007126)3.05692507
106regulation of spindle organization (GO:0090224)3.05351008
107centriole replication (GO:0007099)3.04625225
108spindle checkpoint (GO:0031577)3.03720637
109regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.02870099
110maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.02812807
111negative regulation of chromatin modification (GO:1903309)3.01336460
112regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.01312117
113male meiosis I (GO:0007141)3.00825892
114myeloid dendritic cell differentiation (GO:0043011)2.99823317
115chromosome organization (GO:0051276)2.98595170
116negative regulation of gene silencing (GO:0060969)2.98372378
117telomere maintenance via telomere lengthening (GO:0010833)2.97521520
118spindle assembly involved in mitosis (GO:0090307)2.96782418
119regulation of chromatin silencing (GO:0031935)2.96769442
120trophectodermal cell differentiation (GO:0001829)2.96194135
121cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.94280069
122DNA topological change (GO:0006265)2.93901873
123retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.93011810
124positive regulation of osteoclast differentiation (GO:0045672)2.92776938
125meiotic cell cycle process (GO:1903046)2.90723581
126B cell receptor signaling pathway (GO:0050853)2.90609419
127DNA conformation change (GO:0071103)2.90418536
128monoubiquitinated protein deubiquitination (GO:0035520)2.90158943
129positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.89479847
130chromatin assembly (GO:0031497)2.89079830
131DNA ligation (GO:0006266)2.88788388
132regulation of mitotic sister chromatid segregation (GO:0033047)2.88657909
133positive regulation of Cdc42 GTPase activity (GO:0043089)2.85048665
134regulation of histone H3-K27 methylation (GO:0061085)2.84033556
135histone-serine phosphorylation (GO:0035404)2.81527397
136positive regulation of macrophage differentiation (GO:0045651)2.81196676
137response to interferon-alpha (GO:0035455)2.80508184
138neutrophil activation involved in immune response (GO:0002283)2.78526062
139iron ion import (GO:0097286)2.75835870
140negative regulation of T-helper cell differentiation (GO:0045623)2.73437655
141negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.73437655
142negative T cell selection (GO:0043383)2.69738366
143negative thymic T cell selection (GO:0045060)2.66849838
144regulation of type I interferon-mediated signaling pathway (GO:0060338)2.66682307
145negative regulation of thymocyte apoptotic process (GO:0070244)2.64552891
146mammary gland epithelial cell proliferation (GO:0033598)2.63920996
147myeloid dendritic cell activation (GO:0001773)2.60150960
148trabecula morphogenesis (GO:0061383)2.56739553
149T cell migration (GO:0072678)2.53885520
150spliceosomal tri-snRNP complex assembly (GO:0000244)2.51428570
151microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.50570592
152alpha-beta T cell differentiation (GO:0046632)2.50518418
153antigen processing and presentation via MHC class Ib (GO:0002475)2.49786770
154negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.45334566
155poly(A)+ mRNA export from nucleus (GO:0016973)2.44531996
156nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (GO:0035872)2.41307005
157negative regulation of B cell proliferation (GO:0030889)2.40925543
158cytoplasmic mRNA processing body assembly (GO:0033962)2.40194988
159heart trabecula morphogenesis (GO:0061384)2.39531347
160mRNA splice site selection (GO:0006376)2.37551807
161positive regulation of myeloid leukocyte differentiation (GO:0002763)2.35227441
162necroptotic process (GO:0070266)2.34358863
163I-kappaB phosphorylation (GO:0007252)2.32609800
164positive T cell selection (GO:0043368)2.30151543
165replicative senescence (GO:0090399)2.29997794
166histone phosphorylation (GO:0016572)2.29205028
167positive regulation of natural killer cell mediated immunity (GO:0002717)2.28523099
168alpha-beta T cell activation (GO:0046631)2.28522552
169regulation of gamma-delta T cell differentiation (GO:0045586)2.28183333
170positive thymic T cell selection (GO:0045059)2.27877512
171protein localization to microtubule (GO:0035372)2.26812858
172lymph node development (GO:0048535)2.25294263
173negative regulation of stress fiber assembly (GO:0051497)2.25085413
174regulation of natural killer cell mediated immunity (GO:0002715)2.24924979
175regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.24924979
176positive regulation of keratinocyte differentiation (GO:0045618)2.24867603
177T cell receptor signaling pathway (GO:0050852)2.23387602
178regulation of necroptotic process (GO:0060544)2.22932323
179cytokine biosynthetic process (GO:0042089)2.22687133
180regulation of mitotic spindle organization (GO:0060236)2.21457233
181positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.20500967
182antigen receptor-mediated signaling pathway (GO:0050851)2.19919914
183B cell proliferation (GO:0042100)2.19620124
184activation of Rac GTPase activity (GO:0032863)2.17423817
185interleukin-1-mediated signaling pathway (GO:0070498)2.17133418
186B cell homeostasis (GO:0001782)2.16175245
187thymic T cell selection (GO:0045061)2.16154507
188cellular response to gamma radiation (GO:0071480)2.13219527
189Arp2/3 complex-mediated actin nucleation (GO:0034314)2.12751407

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.93947597
2E2F4_17652178_ChIP-ChIP_JURKAT_Human5.22809416
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.43962276
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.29445028
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.85030326
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.58168351
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.20498824
8RUNX_20019798_ChIP-Seq_JUKART_Human3.09577851
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.75437081
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.72205235
11* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.64662728
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.63924743
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.52558116
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.48110670
15ESR1_20079471_ChIP-ChIP_T-47D_Human2.44517459
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.34744613
17AR_21909140_ChIP-Seq_LNCAP_Human2.32595270
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.32569353
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.16103617
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.12905879
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.11971269
22MAF_26560356_Chip-Seq_TH1_Human2.11426129
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.10622787
24MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.06533562
25RBPJ_22232070_ChIP-Seq_NCS_Mouse2.04006709
26E2F7_22180533_ChIP-Seq_HELA_Human11.7980551
27STAT4_19710469_ChIP-ChIP_TH1__Mouse1.96289517
28TP63_19390658_ChIP-ChIP_HaCaT_Human1.91636054
29MYC_19079543_ChIP-ChIP_MESCs_Mouse1.90555396
30MYC_19030024_ChIP-ChIP_MESCs_Mouse1.89176600
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.84209619
32* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.83474934
33SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.82916425
34SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.82150740
35SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.82150740
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.72938742
37NELFA_20434984_ChIP-Seq_ESCs_Mouse1.72798212
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.71422139
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.67676375
40MYCN_18555785_ChIP-Seq_MESCs_Mouse1.66072320
41* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.64289807
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.63302858
43KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.63301621
44ELK1_19687146_ChIP-ChIP_HELA_Human1.62051409
45UTX_26944678_Chip-Seq_JUKART_Human1.60063169
46MYC_22102868_ChIP-Seq_BL_Human1.59201313
47TCF7_22412390_ChIP-Seq_EML_Mouse1.59009495
48BRD4_25478319_ChIP-Seq_HGPS_Human1.53547791
49E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.53414734
50KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.53360016
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.52224896
52SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.50628928
53RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45469497
54* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.45347805
55IRF8_27001747_Chip-Seq_BMDM_Mouse1.45013228
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.43170713
57CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.41547429
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41236181
59RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.37189253
60ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36674769
61VDR_23849224_ChIP-Seq_CD4+_Human1.35756751
62KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.34790184
63MYC_18358816_ChIP-ChIP_MESCs_Mouse1.34753804
64SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.33914337
65TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32749654
66FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.32094503
67RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32043311
68FOXP3_21729870_ChIP-Seq_TREG_Human1.30946060
69XRN2_22483619_ChIP-Seq_HELA_Human1.29328933
70CREB1_15753290_ChIP-ChIP_HEK293T_Human1.26472364
71VDR_21846776_ChIP-Seq_THP-1_Human1.25962705
72SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.25637484
73KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.24357950
74* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24204006
75EST1_17652178_ChIP-ChIP_JURKAT_Human1.24183729
76MAF_26560356_Chip-Seq_TH2_Human1.22467938
77SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.22399533
78TTF2_22483619_ChIP-Seq_HELA_Human1.21996389
79FOXO3_23340844_ChIP-Seq_DLD1_Human1.20314302
80SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.19549569
81FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.19295065
82HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.17575262
83HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17048540
84KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16669829
85SPI1_23127762_ChIP-Seq_K562_Human1.16071790
86CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.14514676
87* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.12880371
88* PU_27001747_Chip-Seq_BMDM_Mouse1.12346098
89TFEB_21752829_ChIP-Seq_HELA_Human1.10486293
90* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.09949576
91ELK3_25401928_ChIP-Seq_HUVEC_Human1.09608033
92YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08961956
93GATA3_27048872_Chip-Seq_THYMUS_Human1.08884543
94P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08634809
95* KDM5A_27292631_Chip-Seq_BREAST_Human1.08317823
96Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.08145016
97HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.07861546
98POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07718520
99PKCTHETA_26484144_Chip-Seq_BREAST_Human1.06077466
100KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06023635
101E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05884143
102PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04498136
103TP53_22127205_ChIP-Seq_IMR90_Human1.01467587
104FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01254922
105MYC_18940864_ChIP-ChIP_HL60_Human1.01237067
106* FLI1_27457419_Chip-Seq_LIVER_Mouse1.01080118
107KDM2B_26808549_Chip-Seq_JURKAT_Human1.01044824
108HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00680076
109SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00577511
110PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00223000
111VDR_24763502_ChIP-Seq_THP-1_Human0.99818500
112NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99740122
113CIITA_25753668_ChIP-Seq_RAJI_Human0.96574225
114* IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.95852124
115TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.95435015
116* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94363754
117KDM2B_26808549_Chip-Seq_DND41_Human0.94186143
118ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.94102853
119NOTCH1_21737748_ChIP-Seq_TLL_Human0.93327355
120* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92221272
121FUS_26573619_Chip-Seq_HEK293_Human0.91994674
122DCP1A_22483619_ChIP-Seq_HELA_Human0.91928725
123TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91230192
124GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91027948
125ELF1_17652178_ChIP-ChIP_JURKAT_Human0.90109178
126EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.89461912
127JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89429456
128* SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.89139497
129ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.89045392
130EWS_26573619_Chip-Seq_HEK293_Human0.87954602
131* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.87210210
132ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.87198952
133RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.86908415
134ATF3_27146783_Chip-Seq_COLON_Human0.86038725
135FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.85687569
136E2F1_18555785_ChIP-Seq_MESCs_Mouse0.85671871
137POU5F1_16153702_ChIP-ChIP_HESCs_Human0.85056303
138SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.83704240
139GATA3_26560356_Chip-Seq_TH2_Human0.83417729
140EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.83146176
141ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.82456810
142NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.80909492
143DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.80850217
144PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.80768681
145* PCGF2_27294783_Chip-Seq_ESCs_Mouse0.80667475
146GATA1_22383799_ChIP-Seq_G1ME_Mouse0.80136208
147* CJUN_26792858_Chip-Seq_BT549_Human0.79821226
148* MYB_26560356_Chip-Seq_TH1_Human0.78844421
149* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.78360839
150ERG_20887958_ChIP-Seq_HPC-7_Mouse0.78320166
151NANOG_21062744_ChIP-ChIP_HESCs_Human0.78230193
152* GABP_19822575_ChIP-Seq_HepG2_Human0.78201229
153KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.74798662
154KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.74798662
155KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.74798662
156MYB_26560356_Chip-Seq_TH2_Human0.73960379
157STAT3_1855785_ChIP-Seq_MESCs_Mouse0.73718249
158GABP_17652178_ChIP-ChIP_JURKAT_Human0.73254718
159HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.72737157
160SMAD_19615063_ChIP-ChIP_OVARY_Human0.72647834
161EZH2_22144423_ChIP-Seq_EOC_Human0.72502494
162* ETS1_20019798_ChIP-Seq_JURKAT_Human0.72062907
163ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.70066954
164NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.67952092
165SOX2_16153702_ChIP-ChIP_HESCs_Human0.66505054
166CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.64869743
167THAP11_20581084_ChIP-Seq_MESCs_Mouse0.64464053
168NANOG_16153702_ChIP-ChIP_HESCs_Human0.64445986
169SPI1_23547873_ChIP-Seq_NB4_Human0.64313706

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.61643768
2MP0008057_abnormal_DNA_replication3.73914877
3MP0003693_abnormal_embryo_hatching3.37545773
4MP0008877_abnormal_DNA_methylation3.22588908
5MP0003111_abnormal_nucleus_morphology3.21317011
6MP0003077_abnormal_cell_cycle3.19324880
7MP0003436_decreased_susceptibility_to3.15712523
8MP0008007_abnormal_cellular_replicative2.95707946
9MP0008058_abnormal_DNA_repair2.84733271
10MP0004957_abnormal_blastocyst_morpholog2.68856835
11MP0001348_abnormal_lacrimal_gland2.60024011
12MP0005387_immune_system_phenotype2.56216139
13MP0001790_abnormal_immune_system2.56216139
14MP0002933_joint_inflammation2.39847767
15MP0010307_abnormal_tumor_latency2.39619898
16MP0003705_abnormal_hypodermis_morpholog2.33508818
17MP0006292_abnormal_olfactory_placode2.31224052
18MP0005671_abnormal_response_to2.16799930
19* MP0002210_abnormal_sex_determination2.16478543
20MP0005410_abnormal_fertilization2.08116018
21* MP0001929_abnormal_gametogenesis2.08112384
22MP0008932_abnormal_embryonic_tissue2.07240176
23MP0003950_abnormal_plasma_membrane2.05950623
24MP0003786_premature_aging2.05188862
25MP0009785_altered_susceptibility_to2.04168718
26MP0003091_abnormal_cell_migration2.01834939
27MP0010234_abnormal_vibrissa_follicle1.99349291
28MP0004808_abnormal_hematopoietic_stem1.97996024
29MP0010155_abnormal_intestine_physiology1.97691953
30MP0002009_preneoplasia1.97067061
31MP0000858_altered_metastatic_potential1.95391534
32MP0001849_ear_inflammation1.94170504
33MP0000350_abnormal_cell_proliferation1.89075669
34MP0005000_abnormal_immune_tolerance1.88167594
35MP0003300_gastrointestinal_ulcer1.81682723
36MP0003566_abnormal_cell_adhesion1.78361526
37MP0008438_abnormal_cutaneous_collagen1.77067359
38MP0000569_abnormal_digit_pigmentation1.76997137
39* MP0002723_abnormal_immune_serum1.76185718
40* MP0002420_abnormal_adaptive_immunity1.75078217
41* MP0001145_abnormal_male_reproductive1.73762875
42* MP0001819_abnormal_immune_cell1.69750303
43* MP0003698_abnormal_male_reproductive1.63935820
44MP0003448_altered_tumor_morphology1.63261446
45MP0005310_abnormal_salivary_gland1.60668326
46MP0010352_gastrointestinal_tract_polyps1.58480556
47* MP0000653_abnormal_sex_gland1.57615216
48MP0001730_embryonic_growth_arrest1.56514270
49MP0002405_respiratory_system_inflammati1.53389777
50MP0005025_abnormal_response_to1.52675303
51MP0000685_abnormal_immune_system1.51075288
52MP0005076_abnormal_cell_differentiation1.50153652
53MP0003890_abnormal_embryonic-extraembry1.47197259
54MP0005023_abnormal_wound_healing1.44908781
55MP0002160_abnormal_reproductive_system1.43562509
56MP0001672_abnormal_embryogenesis/_devel1.42208957
57MP0005380_embryogenesis_phenotype1.42208957
58MP0001873_stomach_inflammation1.41613869
59* MP0000716_abnormal_immune_system1.39262686
60MP0006082_CNS_inflammation1.39001856
61MP0002084_abnormal_developmental_patter1.38230560
62MP0001697_abnormal_embryo_size1.38062110
63MP0003136_yellow_coat_color1.36459771
64MP0003937_abnormal_limbs/digits/tail_de1.36299992
65MP0001293_anophthalmia1.36013043
66MP0002653_abnormal_ependyma_morphology1.35537015
67MP0002085_abnormal_embryonic_tissue1.35044446
68MP0006054_spinal_hemorrhage1.34952017
69MP0003121_genomic_imprinting1.33507258
70MP0001853_heart_inflammation1.33273120
71MP0002396_abnormal_hematopoietic_system1.31660744
72MP0003123_paternal_imprinting1.31331229
73MP0002019_abnormal_tumor_incidence1.29038711
74MP0000733_abnormal_muscle_development1.28233995
75MP0000490_abnormal_crypts_of1.27262784
76MP0002419_abnormal_innate_immunity1.27168256
77MP0003787_abnormal_imprinting1.26974919
78MP0004197_abnormal_fetal_growth/weight/1.26556594
79MP0003718_maternal_effect1.25320574
80MP0003315_abnormal_perineum_morphology1.25196223
81MP0004185_abnormal_adipocyte_glucose1.25107319
82MP0001533_abnormal_skeleton_physiology1.25064537
83MP0000313_abnormal_cell_death1.21125597
84MP0001119_abnormal_female_reproductive1.20686122
85MP0001919_abnormal_reproductive_system1.20355696
86MP0003984_embryonic_growth_retardation1.19840281
87MP0005389_reproductive_system_phenotype1.19790596
88MP0001243_abnormal_dermal_layer1.17974803
89MP0002088_abnormal_embryonic_growth/wei1.16661429
90MP0003828_pulmonary_edema1.15416611
91* MP0002429_abnormal_blood_cell1.14828545
92MP0001851_eye_inflammation1.14752228
93MP0000015_abnormal_ear_pigmentation1.11073759
94MP0003191_abnormal_cellular_cholesterol1.09242829
95MP0000013_abnormal_adipose_tissue1.09010964
96* MP0002161_abnormal_fertility/fecundity1.08468287
97MP0002086_abnormal_extraembryonic_tissu1.06461228
98MP0002998_abnormal_bone_remodeling1.06281053
99MP0002095_abnormal_skin_pigmentation1.06074230
100MP0009333_abnormal_splenocyte_physiolog1.06073619
101MP0002080_prenatal_lethality1.05507970
102MP0003763_abnormal_thymus_physiology1.05008614
103MP0005623_abnormal_meninges_morphology1.04622669
104MP0002398_abnormal_bone_marrow1.04572643
105MP0002148_abnormal_hypersensitivity_rea1.04360930
106MP0001286_abnormal_eye_development1.03807281
107MP0002177_abnormal_outer_ear1.03183891
108MP0005397_hematopoietic_system_phenotyp1.01301779
109MP0001545_abnormal_hematopoietic_system1.01301779
110MP0000432_abnormal_head_morphology1.00391557
111MP0005174_abnormal_tail_pigmentation0.99681099
112* MP0001800_abnormal_humoral_immune0.99466016
113MP0005621_abnormal_cell_physiology0.98134133
114MP0001958_emphysema0.96873661
115MP0002006_tumorigenesis0.96827402
116MP0004947_skin_inflammation0.96217864
117MP0010030_abnormal_orbit_morphology0.95491136
118MP0005451_abnormal_body_composition0.94260012
119MP0002166_altered_tumor_susceptibility0.93913585
120MP0002697_abnormal_eye_size0.93477603
121MP0001845_abnormal_inflammatory_respons0.91449680
122MP0003252_abnormal_bile_duct0.91446614
123MP0008789_abnormal_olfactory_epithelium0.90160150
124MP0002092_abnormal_eye_morphology0.89857609
125MP0000767_abnormal_smooth_muscle0.89447751
126MP0003755_abnormal_palate_morphology0.88901042
127MP0008995_early_reproductive_senescence0.88816059
128MP0002138_abnormal_hepatobiliary_system0.88708075
129* MP0000689_abnormal_spleen_morphology0.88443741
130MP0001346_abnormal_lacrimal_gland0.87703525
131MP0002249_abnormal_larynx_morphology0.86793921
132MP0003935_abnormal_craniofacial_develop0.86407081
133* MP0000627_abnormal_mammary_gland0.85496748
134MP0000703_abnormal_thymus_morphology0.85272960
135MP0003567_abnormal_fetal_cardiomyocyte0.84536936
136MP0002877_abnormal_melanocyte_morpholog0.83688233
137MP0005164_abnormal_response_to0.82660934
138MP0001835_abnormal_antigen_presentation0.82657533
139MP0000631_abnormal_neuroendocrine_gland0.82371710
140MP0004134_abnormal_chest_morphology0.81942070
141MP0009379_abnormal_foot_pigmentation0.81840083
142* MP0003699_abnormal_female_reproductive0.81802024
143MP0002060_abnormal_skin_morphology0.80259244
144MP0002282_abnormal_trachea_morphology0.80213632
145MP0005409_darkened_coat_color0.79445650
146MP0001529_abnormal_vocalization0.79020502
147MP0003279_aneurysm0.78899163
148MP0001915_intracranial_hemorrhage0.78617459
149MP0000566_synostosis0.77572428
150MP0005464_abnormal_platelet_physiology0.77430261
151MP0008873_increased_physiological_sensi0.76474170
152MP0003938_abnormal_ear_development0.76242065
153MP0000427_abnormal_hair_cycle0.75732460
154MP0002233_abnormal_nose_morphology0.75692981
155MP0000003_abnormal_adipose_tissue0.75207222
156MP0003941_abnormal_skin_development0.74771184
157MP0003453_abnormal_keratinocyte_physiol0.73797523
158MP0001216_abnormal_epidermal_layer0.73397588
159MP0003795_abnormal_bone_structure0.73202381
160MP0000428_abnormal_craniofacial_morphol0.73092234
161MP0003861_abnormal_nervous_system0.72876231
162* MP0002722_abnormal_immune_system0.72779766
163MP0000049_abnormal_middle_ear0.72638216
164MP0002254_reproductive_system_inflammat0.70880738
165MP0009278_abnormal_bone_marrow0.70781413
166MP0002928_abnormal_bile_duct0.70508401
167MP0003221_abnormal_cardiomyocyte_apopto0.69889103
168MP0003115_abnormal_respiratory_system0.69703059
169MP0004233_abnormal_muscle_weight0.69654165
170* MP0002452_abnormal_antigen_presenting0.68779740
171MP0001188_hyperpigmentation0.68659513
172MP0003866_abnormal_defecation0.68071692

Predicted human phenotypes

RankGene SetZ-score
1Chronic otitis media (HP:0000389)6.94559231
2Nasal polyposis (HP:0100582)5.74822468
3Abnormality of the nasal mucosa (HP:0000433)4.60625084
4Chromsome breakage (HP:0040012)4.51010751
5Periodontitis (HP:0000704)4.27720387
6Chronic sinusitis (HP:0011109)4.19407590
7Chromosomal breakage induced by crosslinking agents (HP:0003221)4.17724216
8Osteolytic defects of the hand bones (HP:0009699)4.17142529
9Osteolytic defects of the phalanges of the hand (HP:0009771)4.17142529
10Recurrent cutaneous fungal infections (HP:0011370)4.01798116
11Chronic mucocutaneous candidiasis (HP:0002728)4.01798116
12Abnormality of chromosome stability (HP:0003220)3.98824984
13T lymphocytopenia (HP:0005403)3.94402059
14Abnormality of T cell number (HP:0011839)3.56728363
15Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.51942557
16Meckel diverticulum (HP:0002245)3.44778600
17Aplasia/Hypoplasia of the uvula (HP:0010293)3.41272412
18Impulsivity (HP:0100710)3.35883159
19Supernumerary spleens (HP:0009799)3.26700859
20Abnormality of the ileum (HP:0001549)3.25264242
21Abnormality of the preputium (HP:0100587)3.21954306
22Emphysema (HP:0002097)3.15307023
23Premature rupture of membranes (HP:0001788)3.12295273
24Absent/shortened dynein arms (HP:0200106)2.88963419
25Dynein arm defect of respiratory motile cilia (HP:0012255)2.88963419
2611 pairs of ribs (HP:0000878)2.81619710
27Volvulus (HP:0002580)2.81360684
28Abnormal foot bone ossification (HP:0010675)2.81121287
29Cheilitis (HP:0100825)2.76265305
30Ectopic kidney (HP:0000086)2.73814886
31Flattened epiphyses (HP:0003071)2.73391355
32Metaphyseal cupping (HP:0003021)2.73156155
33Recurrent fungal infections (HP:0002841)2.71861361
34Small intestinal stenosis (HP:0012848)2.71852689
35Duodenal stenosis (HP:0100867)2.71852689
36Recurrent bacterial skin infections (HP:0005406)2.69483764
37Hypothermia (HP:0002045)2.69141855
38Abnormality of the carotid arteries (HP:0005344)2.67155832
39Clubbing of toes (HP:0100760)2.65567330
40Birth length less than 3rd percentile (HP:0003561)2.65055345
41Abnormality of T cells (HP:0002843)2.64631927
42Recurrent skin infections (HP:0001581)2.59829796
43Recurrent sinusitis (HP:0011108)2.56938702
44Pustule (HP:0200039)2.54623963
45Abnormal delayed hypersensitivity skin test (HP:0002963)2.51531166
46Sloping forehead (HP:0000340)2.50877367
47Myelodysplasia (HP:0002863)2.49793664
48Facial hemangioma (HP:0000329)2.48537854
49Abnormal platelet volume (HP:0011876)2.47854021
50Recurrent viral infections (HP:0004429)2.44362531
51Global brain atrophy (HP:0002283)2.43389599
52Recurrent abscess formation (HP:0002722)2.43240250
53Spinal cord lesions (HP:0100561)2.41980332
54Syringomyelia (HP:0003396)2.41980332
55Nephroblastoma (Wilms tumor) (HP:0002667)2.40417687
56Increased mean platelet volume (HP:0011877)2.39502270
57Short nail (HP:0001799)2.38442927
58Patellar aplasia (HP:0006443)2.36396018
59Selective tooth agenesis (HP:0001592)2.35491726
60Acute myeloid leukemia (HP:0004808)2.32705156
61Abnormality of the duodenum (HP:0002246)2.32114831
62Premature loss of primary teeth (HP:0006323)2.32049818
63Subacute progressive viral hepatitis (HP:0006572)2.31843711
64Embryonal renal neoplasm (HP:0011794)2.25897425
65Triphalangeal thumb (HP:0001199)2.22995470
66Protrusio acetabuli (HP:0003179)2.22977257
67Truncal obesity (HP:0001956)2.22945256
68Abnormality of the labia minora (HP:0012880)2.22835877
69Medulloblastoma (HP:0002885)2.22726701
70Generalized amyotrophy (HP:0003700)2.22249674
71Abnormality of the distal phalanges of the toes (HP:0010182)2.21816889
72Ectopia lentis (HP:0001083)2.20735864
73Aplasia/Hypoplasia of the patella (HP:0006498)2.19410762
74Missing ribs (HP:0000921)2.19238471
75IgG deficiency (HP:0004315)2.17601521
76Heterotopia (HP:0002282)2.17529096
77Glucose intolerance (HP:0000833)2.16951798
78Abnormal lung lobation (HP:0002101)2.16683873
79Eczematoid dermatitis (HP:0000976)2.16599218
80Absent thumb (HP:0009777)2.16419073
81Abnormality of the fingertips (HP:0001211)2.15180309
82Abnormal respiratory motile cilium physiology (HP:0012261)2.14104659
83Increased nuchal translucency (HP:0010880)2.14039160
84Short 4th metacarpal (HP:0010044)2.13902485
85Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.13902485
86Decreased skull ossification (HP:0004331)2.12491921
87Abnormality of skull ossification (HP:0002703)2.11384446
88Oligodactyly (HP:0012165)2.11331242
89Aortic dissection (HP:0002647)2.11252062
90Abnormal respiratory motile cilium morphology (HP:0005938)2.10771633
91Abnormal respiratory epithelium morphology (HP:0012253)2.10771633
92Chronic diarrhea (HP:0002028)2.09823455
93Oligodactyly (hands) (HP:0001180)2.09087540
94Mitral stenosis (HP:0001718)2.09059331
95Abnormality of the phalanges of the hallux (HP:0010057)2.08745341
96Arterial tortuosity (HP:0005116)2.08063084
97Rhabdomyosarcoma (HP:0002859)2.07993150
98Aortic aneurysm (HP:0004942)2.04793569
99Recurrent bronchitis (HP:0002837)2.04360321
100Deep philtrum (HP:0002002)2.04355618
101Short thumb (HP:0009778)2.04226245
102Rhinitis (HP:0012384)2.03649425
103Gingivitis (HP:0000230)2.01117565
104Lip pit (HP:0100267)2.00311389
105IgA deficiency (HP:0002720)1.98844284
106Dislocated radial head (HP:0003083)1.98824719
107Reticulocytopenia (HP:0001896)1.97514284
108Nephronophthisis (HP:0000090)1.96182513
109Sparse lateral eyebrow (HP:0005338)1.96150311
110Capillary hemangiomas (HP:0005306)1.95474587
111Autoimmune hemolytic anemia (HP:0001890)1.95375125
112Flat acetabular roof (HP:0003180)1.94619339
113Aplasia/Hypoplasia of the earlobes (HP:0009906)1.94503084
114Broad face (HP:0000283)1.94334131
115Prominent nose (HP:0000448)1.93813853
116Agammaglobulinemia (HP:0004432)1.92414042
117Ankle contracture (HP:0006466)1.91712825
118Tracheoesophageal fistula (HP:0002575)1.91373997
119Breast hypoplasia (HP:0003187)1.91301801
120Abnormality of the anterior horn cell (HP:0006802)1.90548235
121Degeneration of anterior horn cells (HP:0002398)1.90548235
122Abnormality of the calcaneus (HP:0008364)1.90516427
123Skin ulcer (HP:0200042)1.89848298
124Vascular tortuosity (HP:0004948)1.89488660
125Abnormality of chromosome segregation (HP:0002916)1.88728670
126Absent radius (HP:0003974)1.88178792
127Absent frontal sinuses (HP:0002688)1.86051176
128Abnormality of T cell physiology (HP:0011840)1.84522892
129Panhypogammaglobulinemia (HP:0003139)1.84297270
130Dilatation of the ascending aorta (HP:0005111)1.83183210
131Cafe-au-lait spot (HP:0000957)1.82780469
132Coxa vara (HP:0002812)1.81527065
133Spondylolisthesis (HP:0003302)1.80905269
134Bone marrow hypocellularity (HP:0005528)1.80877649
135Hypoplasia of the capital femoral epiphysis (HP:0003090)1.80519638
136Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.80067634
137Peritonitis (HP:0002586)1.79718656
138Leukopenia (HP:0001882)1.78702198
139Abnormality of the radial head (HP:0003995)1.78567508
140Micronodular cirrhosis (HP:0001413)1.78356281
141Colon cancer (HP:0003003)1.77722473
142Enlarged epiphyses (HP:0010580)1.76930578
143Poikiloderma (HP:0001029)1.76110265
144Gonadotropin excess (HP:0000837)1.75500888
145Bronchitis (HP:0012387)1.74016830
146Aplasia involving forearm bones (HP:0009822)1.73800317
147Absent forearm bone (HP:0003953)1.73800317
148Cellulitis (HP:0100658)1.73195461
149Squamous cell carcinoma (HP:0002860)1.72223042
150Abnormal spermatogenesis (HP:0008669)1.71743693
151Lymphoma (HP:0002665)1.71012763
152Reduced subcutaneous adipose tissue (HP:0003758)1.70946928
153Thick nail (HP:0001805)1.70932837
154Cubitus valgus (HP:0002967)1.70604428
155Abnormality of oral frenula (HP:0000190)1.70516933
156Abnormality of DNA repair (HP:0003254)1.70461236
157Encephalitis (HP:0002383)1.68313601
158Recurrent lower respiratory tract infections (HP:0002783)1.68153492
159Viral hepatitis (HP:0006562)1.67579745
160Abnormality of the distal phalanx of the thumb (HP:0009617)1.66763851
161Microglossia (HP:0000171)1.65864181
162Abdominal situs inversus (HP:0003363)1.64780951
163Abnormality of abdominal situs (HP:0011620)1.64780951
164Cardiovascular calcification (HP:0011915)1.64470944
165Mesomelia (HP:0003027)1.64247102
166Abnormality of cells of the lymphoid lineage (HP:0012140)1.64208717
167Cutaneous melanoma (HP:0012056)1.63669074
168Keratoconjunctivitis sicca (HP:0001097)1.62925760
169Median cleft lip (HP:0000161)1.62487886
170Distal lower limb amyotrophy (HP:0008944)1.62456825
171Lymphopenia (HP:0001888)1.61827887
172High pitched voice (HP:0001620)1.61653990
173Increased density of long bones (HP:0006392)1.61601840
174Arteriovenous malformation (HP:0100026)1.61171378
175Cleft eyelid (HP:0000625)1.59829787
176Entropion (HP:0000621)1.59757957
177Orchitis (HP:0100796)1.59352814
178Papillary thyroid carcinoma (HP:0002895)1.58852901
179Meningitis (HP:0001287)1.58724631
180Atresia of the external auditory canal (HP:0000413)1.58577049
181Mitral regurgitation (HP:0001653)1.58445284
182Horseshoe kidney (HP:0000085)1.56870675
183Abnormality of the renal medulla (HP:0100957)1.56832766
184Basal cell carcinoma (HP:0002671)1.55538117
185Neoplasm of the oral cavity (HP:0100649)1.55147215

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K138.40434294
2CDC75.68448408
3NEK23.66419319
4MAP3K143.32293875
5SRPK13.31522955
6WEE13.01640430
7CDK122.78186364
8MAP3K92.57428301
9LATS12.54496627
10BRSK22.37535015
11MKNK22.35113078
12CHEK22.34235167
13ACVR1B2.32196412
14TXK2.31530310
15MKNK12.29097862
16BMPR22.26267338
17TRIB32.23236846
18PLK42.15266327
19MOS2.08346652
20ARAF2.06035947
21ATR1.95981378
22TTK1.91462929
23PLK11.91423641
24TAOK31.82414150
25STK31.80798216
26ERN11.80304548
27AURKB1.80236147
28TLK11.80181624
29PDK31.79361113
30PDK41.79361113
31TTN1.76231622
32MST1R1.66458478
33JAK31.61785727
34DYRK31.59524708
35BUB11.56051228
36JAK11.55292316
37KSR21.54972568
38EIF2AK11.52773462
39CDK71.50788260
40CDK61.50339756
41CDK41.45051371
42RPS6KA41.44463912
43CHEK11.43658340
44TYK21.43030695
45MUSK1.39872919
46STK41.39412427
47PLK31.38585999
48EIF2AK31.29521129
49SIK11.29488319
50STK101.28826677
51MAP2K31.28256406
52ATM1.27892992
53ZAK1.25815341
54PRPF4B1.21871166
55ILK1.21198892
56YES11.20405991
57PIM11.19295308
58BRD41.16824478
59CCNB11.16468111
60VRK11.16362274
61MAP3K101.14894436
62KSR11.12895642
63STK38L1.12747637
64NEK11.11620752
65BRSK11.11325040
66CDK91.10607422
67MAP4K11.09202198
68DYRK1B1.04905983
69NME21.00706475
70ZAP700.97934838
71SIK30.96614633
72RPS6KB20.95717009
73CLK10.94222807
74MAP3K30.93748172
75PRKD20.91074840
76MELK0.89035844
77PRKCI0.88947558
78TGFBR10.88802704
79MAP3K80.88447125
80MET0.88251036
81PASK0.87711153
82EPHB10.86758298
83CDK20.86374881
84TESK10.83171527
85CASK0.82638610
86HCK0.79745344
87RAF10.79412261
88CDK80.79297744
89PTK20.78021829
90CSF1R0.76622461
91IRAK30.74527403
92MAP3K70.73657148
93CDK10.73035745
94MYLK0.72962636
95CSK0.72600022
96PDGFRA0.72387314
97PDK20.72318153
98AURKA0.72285893
99EIF2AK20.71570557
100RPS6KA50.70410487
101NUAK10.70298077
102LATS20.68634820
103PAK40.67977449
104SMG10.67508667
105TRPM70.64146474
106ICK0.62511896
107GRK60.62218725
108PDK10.60832914
109CSNK1D0.59315822
110TEC0.58820770
111EPHA20.58456577
112CDK30.56923969
113LCK0.56468714
114NEK90.55915302
115NLK0.55681921
116IRAK40.54609309
117CHUK0.53459568
118MAPK110.52455005
119TGFBR20.52257176
120PDGFRB0.51512381
121ERBB40.51449974
122EEF2K0.50715265
123ERBB30.50418270
124BLK0.50388605
125PTK2B0.49940063
126SCYL20.48993917
127STK380.46103416
128PIK3CG0.45936765
129MAP3K120.45377847
130SYK0.45224651
131RPS6KB10.44342566
132NEK60.42847117
133PTK60.42146873
134PDPK10.38754532
135BTK0.38457907
136CSNK2A20.37437341
137CSNK1G10.36801205
138MAPK140.36318720
139* CSNK2A10.35695419
140PRKDC0.35361140
141TSSK60.35340560
142BRAF0.34960682
143MTOR0.34379991
144IKBKB0.33544112
145MST40.33058506
146FGFR30.32650871
147LRRK20.32640386
148SGK30.31890204
149SGK20.30233547
150DYRK20.29515751
151HIPK20.28839842
152ABL10.28344832
153PRKCH0.28014535
154ITK0.26127858
155AKT10.25192374
156GSK3B0.24536915
157MAPK10.20951345
158WNK10.18408843
159PLK20.18023965
160LYN0.18003332

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.29282399
2Fanconi anemia pathway_Homo sapiens_hsa034603.65455926
3Mismatch repair_Homo sapiens_hsa034303.64087100
4Homologous recombination_Homo sapiens_hsa034403.39481452
5Cell cycle_Homo sapiens_hsa041103.12428692
6Base excision repair_Homo sapiens_hsa034103.05355160
7Nucleotide excision repair_Homo sapiens_hsa034202.60250299
8RNA transport_Homo sapiens_hsa030132.44145331
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.40803458
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.34784249
11Spliceosome_Homo sapiens_hsa030402.33819074
12p53 signaling pathway_Homo sapiens_hsa041152.33798862
13Basal transcription factors_Homo sapiens_hsa030222.29277132
14Non-homologous end-joining_Homo sapiens_hsa034502.20581076
15mRNA surveillance pathway_Homo sapiens_hsa030151.91086405
16Primary immunodeficiency_Homo sapiens_hsa053401.85240063
17Caffeine metabolism_Homo sapiens_hsa002321.85056283
18Systemic lupus erythematosus_Homo sapiens_hsa053221.80342226
19Osteoclast differentiation_Homo sapiens_hsa043801.75718598
20RNA degradation_Homo sapiens_hsa030181.73005932
21One carbon pool by folate_Homo sapiens_hsa006701.54862888
22Ribosome_Homo sapiens_hsa030101.52906003
23RNA polymerase_Homo sapiens_hsa030201.52806094
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.44458460
25Pyrimidine metabolism_Homo sapiens_hsa002401.44051090
26Renal cell carcinoma_Homo sapiens_hsa052111.44018831
27MicroRNAs in cancer_Homo sapiens_hsa052061.39584617
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.38782828
29Leishmaniasis_Homo sapiens_hsa051401.33067295
30Transcriptional misregulation in cancer_Homo sapiens_hsa052021.31259989
31Viral carcinogenesis_Homo sapiens_hsa052031.31090629
32Inositol phosphate metabolism_Homo sapiens_hsa005621.30974202
33Hepatitis C_Homo sapiens_hsa051601.28325629
34Herpes simplex infection_Homo sapiens_hsa051681.26280537
35Oocyte meiosis_Homo sapiens_hsa041141.25749970
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.16772918
37Graft-versus-host disease_Homo sapiens_hsa053321.16519089
38Small cell lung cancer_Homo sapiens_hsa052221.15558784
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15256089
40Antigen processing and presentation_Homo sapiens_hsa046121.11814656
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.11012087
42B cell receptor signaling pathway_Homo sapiens_hsa046621.10680942
43* HTLV-I infection_Homo sapiens_hsa051661.07291276
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.03118591
45Epstein-Barr virus infection_Homo sapiens_hsa051690.99435130
46NF-kappa B signaling pathway_Homo sapiens_hsa040640.98795275
47Alcoholism_Homo sapiens_hsa050340.95045668
48Sphingolipid signaling pathway_Homo sapiens_hsa040710.94857425
49VEGF signaling pathway_Homo sapiens_hsa043700.92567457
50Thyroid cancer_Homo sapiens_hsa052160.92414646
51Colorectal cancer_Homo sapiens_hsa052100.89311538
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.88681762
53Purine metabolism_Homo sapiens_hsa002300.86967472
54Chemokine signaling pathway_Homo sapiens_hsa040620.86379962
55Allograft rejection_Homo sapiens_hsa053300.86193411
56Hepatitis B_Homo sapiens_hsa051610.85617564
57Prostate cancer_Homo sapiens_hsa052150.83163499
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.82931520
59Platelet activation_Homo sapiens_hsa046110.82885547
60Chronic myeloid leukemia_Homo sapiens_hsa052200.82407990
61Measles_Homo sapiens_hsa051620.81838462
62TGF-beta signaling pathway_Homo sapiens_hsa043500.81685182
63Pancreatic cancer_Homo sapiens_hsa052120.81267530
64ErbB signaling pathway_Homo sapiens_hsa040120.80743945
65Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.80422440
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77014473
67Endocytosis_Homo sapiens_hsa041440.76021337
68Adherens junction_Homo sapiens_hsa045200.75371746
69Malaria_Homo sapiens_hsa051440.74993360
70Viral myocarditis_Homo sapiens_hsa054160.71880933
71Basal cell carcinoma_Homo sapiens_hsa052170.71050458
72Wnt signaling pathway_Homo sapiens_hsa043100.68816196
73Tuberculosis_Homo sapiens_hsa051520.68418191
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.67864686
75Notch signaling pathway_Homo sapiens_hsa043300.65500826
76Bladder cancer_Homo sapiens_hsa052190.64930293
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64609498
78MAPK signaling pathway_Homo sapiens_hsa040100.63599031
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63551312
80Shigellosis_Homo sapiens_hsa051310.62749517
81Non-small cell lung cancer_Homo sapiens_hsa052230.62505213
82Hippo signaling pathway_Homo sapiens_hsa043900.62445976
83FoxO signaling pathway_Homo sapiens_hsa040680.61140808
84Dorso-ventral axis formation_Homo sapiens_hsa043200.60785577
85Choline metabolism in cancer_Homo sapiens_hsa052310.58590537
86Endometrial cancer_Homo sapiens_hsa052130.58341527
87Pathways in cancer_Homo sapiens_hsa052000.57132973
88Insulin signaling pathway_Homo sapiens_hsa049100.56994624
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56783942
90Influenza A_Homo sapiens_hsa051640.55951548
91Apoptosis_Homo sapiens_hsa042100.54799205
92Melanoma_Homo sapiens_hsa052180.53474291
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.50914363
94Acute myeloid leukemia_Homo sapiens_hsa052210.50275236
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49478499
96Hematopoietic cell lineage_Homo sapiens_hsa046400.49439337
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49055971
98Insulin resistance_Homo sapiens_hsa049310.48863027
99Estrogen signaling pathway_Homo sapiens_hsa049150.48476447
100Proteoglycans in cancer_Homo sapiens_hsa052050.48095966
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.46202438
102Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.46167028
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45718457
104N-Glycan biosynthesis_Homo sapiens_hsa005100.45668102
105Ras signaling pathway_Homo sapiens_hsa040140.45414089
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45306038
107HIF-1 signaling pathway_Homo sapiens_hsa040660.43390277
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43181433
109Prolactin signaling pathway_Homo sapiens_hsa049170.42573407
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41456776
111Lysine degradation_Homo sapiens_hsa003100.40928599
112Selenocompound metabolism_Homo sapiens_hsa004500.38814497
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38324497
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36600047
115Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36277550
116T cell receptor signaling pathway_Homo sapiens_hsa046600.35146071
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35040927
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.34769086
119Pentose phosphate pathway_Homo sapiens_hsa000300.34642396
120Glioma_Homo sapiens_hsa052140.34099321
121Hedgehog signaling pathway_Homo sapiens_hsa043400.33947077
122Toxoplasmosis_Homo sapiens_hsa051450.32951343
123Autoimmune thyroid disease_Homo sapiens_hsa053200.32821712
124Salmonella infection_Homo sapiens_hsa051320.32502246
125Vitamin B6 metabolism_Homo sapiens_hsa007500.32015087
126mTOR signaling pathway_Homo sapiens_hsa041500.31500804
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30913395
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.30002325
129RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.29636661
130Leukocyte transendothelial migration_Homo sapiens_hsa046700.28746619
131Focal adhesion_Homo sapiens_hsa045100.28518281
132TNF signaling pathway_Homo sapiens_hsa046680.28433428

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