MXRA5Y

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell migration involved in heart development (GO:0060973)6.94452426
2kidney mesenchyme development (GO:0072074)6.37052237
3collagen fibril organization (GO:0030199)6.29525904
4protein heterotrimerization (GO:0070208)5.80853007
5metanephric mesenchyme development (GO:0072075)5.40298655
6dermatan sulfate biosynthetic process (GO:0030208)4.99153442
7bone trabecula formation (GO:0060346)4.96379720
8cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.81601228
9tooth mineralization (GO:0034505)4.70772195
10mesenchymal-epithelial cell signaling (GO:0060638)4.69632222
11dermatan sulfate metabolic process (GO:0030205)4.66966301
12skin morphogenesis (GO:0043589)4.56080364
13extracellular fibril organization (GO:0043206)4.34364649
14keratan sulfate catabolic process (GO:0042340)4.34182874
15collagen catabolic process (GO:0030574)4.20890236
16sequestering of extracellular ligand from receptor (GO:0035581)4.19369551
17collagen metabolic process (GO:0032963)4.16183089
18chondrocyte proliferation (GO:0035988)4.04694415
19atrioventricular valve morphogenesis (GO:0003181)4.03474344
20pericardium development (GO:0060039)4.01876032
21endocardial cushion development (GO:0003197)4.01412669
22basement membrane organization (GO:0071711)3.95726784
23glomerular basement membrane development (GO:0032836)3.95613884
24axon extension involved in axon guidance (GO:0048846)3.91383296
25neuron projection extension involved in neuron projection guidance (GO:1902284)3.91383296
26peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.89207530
27multicellular organismal macromolecule metabolic process (GO:0044259)3.88340022
28multicellular organismal catabolic process (GO:0044243)3.85892845
29craniofacial suture morphogenesis (GO:0097094)3.78255838
30regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.75914988
31endodermal cell differentiation (GO:0035987)3.72325382
32multicellular organismal metabolic process (GO:0044236)3.70020601
33cell proliferation involved in metanephros development (GO:0072203)3.66493992
34embryonic cranial skeleton morphogenesis (GO:0048701)3.65873297
35middle ear morphogenesis (GO:0042474)3.64656189
36establishment of planar polarity (GO:0001736)3.61283541
37establishment of tissue polarity (GO:0007164)3.61283541
38extracellular matrix assembly (GO:0085029)3.60852739
39extracellular matrix disassembly (GO:0022617)3.58650772
40positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)3.58494240
41fibril organization (GO:0097435)3.52497933
42dopaminergic neuron differentiation (GO:0071542)3.52206216
43vascular endothelial growth factor signaling pathway (GO:0038084)3.47945329
44regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.45102711
45negative regulation of axon extension involved in axon guidance (GO:0048843)3.43515577
46endocardial cushion morphogenesis (GO:0003203)3.31173294
47cranial suture morphogenesis (GO:0060363)3.29903415
48negative regulation of chondrocyte differentiation (GO:0032331)3.27719655
49positive regulation of catenin import into nucleus (GO:0035413)3.25860835
50positive regulation of fatty acid beta-oxidation (GO:0032000)3.22274307
51positive regulation of gastrulation (GO:2000543)3.20862428
52regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.12169716
53positive regulation of axon extension (GO:0045773)3.11796874
54face morphogenesis (GO:0060325)3.11780726
55cardiac epithelial to mesenchymal transition (GO:0060317)3.08212589
56negative regulation of axon guidance (GO:1902668)3.05884517
57type B pancreatic cell proliferation (GO:0044342)3.05805110
58mesenchyme morphogenesis (GO:0072132)3.04715591
59embryonic forelimb morphogenesis (GO:0035115)3.04250113
60smooth muscle tissue development (GO:0048745)3.03501711
61cell proliferation involved in kidney development (GO:0072111)3.02539168
62extracellular matrix organization (GO:0030198)3.00882121
63extracellular structure organization (GO:0043062)2.99757311
64epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.99622389
65negative regulation of cartilage development (GO:0061037)2.98174874
66chondroitin sulfate catabolic process (GO:0030207)2.96942819
67organ induction (GO:0001759)2.93399346
68lymph vessel development (GO:0001945)2.92642461
69regulation of organ formation (GO:0003156)2.91996749
70positive regulation of SMAD protein import into nucleus (GO:0060391)2.90524217
71positive regulation of epithelial to mesenchymal transition (GO:0010718)2.90331341
72extracellular regulation of signal transduction (GO:1900115)2.87069611
73extracellular negative regulation of signal transduction (GO:1900116)2.87069611
74regulation of histone phosphorylation (GO:0033127)2.86333710
75growth hormone secretion (GO:0030252)2.82517433
76regulation of axon extension involved in axon guidance (GO:0048841)2.82153231
77regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.81777263
78muscle cell migration (GO:0014812)2.80458933
79blood vessel maturation (GO:0001955)2.77926247
80positive regulation of actin filament depolymerization (GO:0030836)2.77857731
81negative regulation of fatty acid transport (GO:2000192)2.77807236
82adhesion of symbiont to host cell (GO:0044650)2.76047368
83virion attachment to host cell (GO:0019062)2.76047368
84sulfur compound catabolic process (GO:0044273)2.74845213
85chondrocyte development (GO:0002063)2.72586859
86regulation of extracellular matrix disassembly (GO:0010715)2.72195008
87regulation of SMAD protein import into nucleus (GO:0060390)2.70783363
88negative regulation of smooth muscle cell migration (GO:0014912)2.69406114
89vasculature development (GO:0001944)2.68631284
90forelimb morphogenesis (GO:0035136)2.68552449
91outer ear morphogenesis (GO:0042473)2.67886098
92positive regulation of osteoblast proliferation (GO:0033690)2.65421402
93regulation of axon guidance (GO:1902667)2.65022821
94non-canonical Wnt signaling pathway (GO:0035567)2.64559336
95regulation of collagen metabolic process (GO:0010712)2.62101470
96positive regulation of endothelial cell apoptotic process (GO:2000353)2.62079422
97regulation of chondrocyte differentiation (GO:0032330)2.61658319
98cellular response to vitamin (GO:0071295)2.60819270
99head development (GO:0060322)2.57869470
100cellular response to amino acid stimulus (GO:0071230)2.57805735

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse5.27391357
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.16045609
3PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.04815227
4EED_16625203_ChIP-ChIP_MESCs_Mouse2.82450857
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.76307194
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.60790836
7SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.52892392
8ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.51806256
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.36921468
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.32869059
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.32869059
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.32766745
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.22444166
14WT1_19549856_ChIP-ChIP_CCG9911_Human2.15596588
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.15274212
16CJUN_26792858_Chip-Seq_BT549_Human2.13309535
17RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.11648573
18TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.07959451
19CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.05476735
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03531930
21EZH2_27304074_Chip-Seq_ESCs_Mouse1.98806102
22BRD4_25478319_ChIP-Seq_HGPS_Human1.92059750
23JARID2_20075857_ChIP-Seq_MESCs_Mouse1.90611452
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.90481639
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87812772
26PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.84791640
27RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.84030753
28VDR_22108803_ChIP-Seq_LS180_Human1.80231755
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.79592954
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.78956492
31JARID2_20064375_ChIP-Seq_MESCs_Mouse1.78532828
32MTF2_20144788_ChIP-Seq_MESCs_Mouse1.77960834
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.77904709
34HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.76991169
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.76422557
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.74191092
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.71479772
38TP53_20018659_ChIP-ChIP_R1E_Mouse1.66769273
39GBX2_23144817_ChIP-Seq_PC3_Human1.65857474
40CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.62072168
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.59246280
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.57271883
43EP300_21415370_ChIP-Seq_HL-1_Mouse1.56244751
44TP53_16413492_ChIP-PET_HCT116_Human1.53398628
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.50076659
46SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.47773658
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.46609045
48TP53_18474530_ChIP-ChIP_U2OS_Human1.46597697
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43411527
50SA1_22415368_ChIP-Seq_MEFs_Mouse1.42913432
51RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42389956
52ESR1_21235772_ChIP-Seq_MCF-7_Human1.38162818
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.35800227
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33215778
55SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.30194867
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27855843
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.24665523
58RING1B_27294783_Chip-Seq_ESCs_Mouse1.20912365
59NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19568498
60NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19568498
61BCAT_22108803_ChIP-Seq_LS180_Human1.17084270
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16204555
63EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.13553430
64SMC1_22415368_ChIP-Seq_MEFs_Mouse1.13449797
65AHR_22903824_ChIP-Seq_MCF-7_Human1.12675801
66ARNT_22903824_ChIP-Seq_MCF-7_Human1.09350427
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07870299
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05990517
69WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03925025
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01534791
71RING1B_27294783_Chip-Seq_NPCs_Mouse1.00239249
72JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99557992
73BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99451641
74SMC3_22415368_ChIP-Seq_MEFs_Mouse0.98959504
75ESR1_20079471_ChIP-ChIP_T-47D_Human0.98745048
76EZH2_27294783_Chip-Seq_NPCs_Mouse0.98688707
77DROSHA_22980978_ChIP-Seq_HELA_Human0.97174479
78ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95905705
79ZNF263_19887448_ChIP-Seq_K562_Human0.95105630
80SMAD3_21741376_ChIP-Seq_EPCs_Human0.94244960
81EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91917728
82SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91238469
83SMAD4_21799915_ChIP-Seq_A2780_Human0.90382906
84WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90335181
85KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.90185822
86NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90172111
87TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.89696772
88RXR_22108803_ChIP-Seq_LS180_Human0.89435567
89PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88999957
90CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.88849581
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87808605
92SMAD3_21741376_ChIP-Seq_HESCs_Human0.87495339
93NR3C1_23031785_ChIP-Seq_PC12_Mouse0.86705873
94EZH2_22144423_ChIP-Seq_EOC_Human0.85787203
95THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.84106956
96TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.83228762
97P300_19829295_ChIP-Seq_ESCs_Human0.83058617
98POU3F2_20337985_ChIP-ChIP_501MEL_Human0.82872395
99AR_25329375_ChIP-Seq_VCAP_Human0.82610145
100ERG_21242973_ChIP-ChIP_JURKAT_Human0.82442680

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen8.03980308
2MP0005503_abnormal_tendon_morphology7.46564258
3MP0005275_abnormal_skin_tensile5.68804032
4MP0003279_aneurysm3.96178454
5MP0003705_abnormal_hypodermis_morpholog3.22681249
6MP0004272_abnormal_basement_membrane3.13763760
7MP0009384_cardiac_valve_regurgitation2.95750113
8MP0003283_abnormal_digestive_organ2.95743600
9MP0005257_abnormal_intraocular_pressure2.86188144
10MP0001542_abnormal_bone_strength2.80132268
11MP0001958_emphysema2.78975781
12MP0005508_abnormal_skeleton_morphology2.69746090
13MP0006054_spinal_hemorrhage2.63649404
14MP0010030_abnormal_orbit_morphology2.43467534
15MP0009250_abnormal_appendicular_skeleto2.38332390
16MP0002295_abnormal_pulmonary_circulatio2.37308595
17MP0002108_abnormal_muscle_morphology2.26074904
18MP0008004_abnormal_stomach_pH1.91268833
19MP0002060_abnormal_skin_morphology1.84101782
20MP0001243_abnormal_dermal_layer1.75196174
21MP0005023_abnormal_wound_healing1.72328288
22MP0000566_synostosis1.70465406
23MP0000767_abnormal_smooth_muscle1.57087771
24MP0000751_myopathy1.50885106
25MP0005390_skeleton_phenotype1.50867968
26MP0009053_abnormal_anal_canal1.40899132
27MP0001299_abnormal_eye_distance/1.36767884
28MP0000534_abnormal_ureter_morphology1.33850939
29MP0000462_abnormal_digestive_system1.31383366
30MP0010368_abnormal_lymphatic_system1.30309370
31MP0002282_abnormal_trachea_morphology1.28641650
32MP0004134_abnormal_chest_morphology1.27588936
33MP0000049_abnormal_middle_ear1.24895979
34MP0002896_abnormal_bone_mineralization1.19722307
35MP0002938_white_spotting1.19359991
36MP0000163_abnormal_cartilage_morphology1.19049327
37MP0002115_abnormal_skeleton_extremities1.17322205
38MP0005623_abnormal_meninges_morphology1.17219351
39MP0003950_abnormal_plasma_membrane1.15950993
40MP0003937_abnormal_limbs/digits/tail_de1.15011574
41MP0003091_abnormal_cell_migration1.14358461
42MP0002254_reproductive_system_inflammat1.11329525
43MP0005171_absent_coat_pigmentation1.07237300
44MP0002933_joint_inflammation1.07206182
45MP0002102_abnormal_ear_morphology1.06172754
46MP0003941_abnormal_skin_development1.04922895
47MP0000538_abnormal_urinary_bladder1.04120214
48MP0000762_abnormal_tongue_morphology1.03401936
49MP0005595_abnormal_vascular_smooth1.03292357
50MP0000749_muscle_degeneration0.97476901
51MP0000013_abnormal_adipose_tissue0.96614125
52MP0005165_increased_susceptibility_to0.95421325
53MP0000516_abnormal_urinary_system0.94526688
54MP0005367_renal/urinary_system_phenotyp0.94526688
55MP0000428_abnormal_craniofacial_morphol0.94129328
56MP0003942_abnormal_urinary_system0.91488575
57MP0002233_abnormal_nose_morphology0.90688672
58MP0003385_abnormal_body_wall0.86310592
59MP0010386_abnormal_urinary_bladder0.85154158
60MP0003755_abnormal_palate_morphology0.84841358
61MP0002113_abnormal_skeleton_development0.83110553
62MP0001879_abnormal_lymphatic_vessel0.80227789
63MP0002116_abnormal_craniofacial_bone0.79875443
64MP0005164_abnormal_response_to0.79761027
65MP0000432_abnormal_head_morphology0.78786133
66MP0003935_abnormal_craniofacial_develop0.78506131
67MP0002109_abnormal_limb_morphology0.78218012
68MP0000537_abnormal_urethra_morphology0.75991284
69MP0003115_abnormal_respiratory_system0.71797279
70MP0002114_abnormal_axial_skeleton0.70457170
71MP0009780_abnormal_chondrocyte_physiolo0.67825590
72MP0002128_abnormal_blood_circulation0.63994795
73MP0004858_abnormal_nervous_system0.63798434
74MP0002249_abnormal_larynx_morphology0.61616637
75MP0010352_gastrointestinal_tract_polyps0.60544669
76MP0001270_distended_abdomen0.59643387
77MP0005369_muscle_phenotype0.59579576
78MP0003448_altered_tumor_morphology0.57679714
79MP0005187_abnormal_penis_morphology0.57467382
80MP0002168_other_aberrant_phenotype0.57369628
81MP0004883_abnormal_blood_vessel0.57158473
82MP0002133_abnormal_respiratory_system0.56269354
83MP0005388_respiratory_system_phenotype0.56269354
84MP0002932_abnormal_joint_morphology0.55895721
85MP0003566_abnormal_cell_adhesion0.54123380
86MP0003186_abnormal_redox_activity0.52902168
87MP0001348_abnormal_lacrimal_gland0.52755687
88MP0002111_abnormal_tail_morphology0.52533844
89MP0003795_abnormal_bone_structure0.52452016
90MP0003638_abnormal_response/metabolism_0.49811348
91MP0000026_abnormal_inner_ear0.46362827
92MP0008260_abnormal_autophagy0.46237930
93MP0000230_abnormal_systemic_arterial0.46192681
94MP0001614_abnormal_blood_vessel0.45966156
95MP0001533_abnormal_skeleton_physiology0.45842865
96MP0002876_abnormal_thyroid_physiology0.45779937
97MP0001175_abnormal_lung_morphology0.45248272
98MP0003119_abnormal_digestive_system0.44409669
99MP0000759_abnormal_skeletal_muscle0.43378183
100MP0000604_amyloidosis0.43332298

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)7.33450993
2Protrusio acetabuli (HP:0003179)6.76365516
3Soft skin (HP:0000977)5.25063808
4Aortic dissection (HP:0002647)4.96988606
5Ankle contracture (HP:0006466)4.61229786
6Bladder diverticulum (HP:0000015)4.45992284
7Follicular hyperkeratosis (HP:0007502)4.44246611
8Vascular tortuosity (HP:0004948)4.31091152
9Abnormality of dentin (HP:0010299)4.19129592
10Aortic aneurysm (HP:0004942)4.18088863
11Broad metatarsal (HP:0001783)4.11317919
12Atrophic scars (HP:0001075)4.08146880
13Spondylolisthesis (HP:0003302)4.01401080
14Neonatal short-limb short stature (HP:0008921)3.96592268
15Wrist flexion contracture (HP:0001239)3.90514290
16Genu recurvatum (HP:0002816)3.70160203
17Fragile skin (HP:0001030)3.57763750
18Peritonitis (HP:0002586)3.56931013
19Arterial tortuosity (HP:0005116)3.54246399
20Type 1 muscle fiber predominance (HP:0003803)3.45403896
21Wormian bones (HP:0002645)3.34848879
22Blue sclerae (HP:0000592)3.30436536
23Bowel diverticulosis (HP:0005222)3.26751917
24Slender build (HP:0001533)3.18179789
25Wide anterior fontanel (HP:0000260)3.08921104
26Hypoplastic ischia (HP:0003175)3.07900225
27Absent frontal sinuses (HP:0002688)3.07608674
28Shallow orbits (HP:0000586)2.98520648
29Breech presentation (HP:0001623)2.97745641
30Mild short stature (HP:0003502)2.96342489
31Nonimmune hydrops fetalis (HP:0001790)2.93832656
32Cervical subluxation (HP:0003308)2.91835773
33Bell-shaped thorax (HP:0001591)2.90532340
34Dilatation of the ascending aorta (HP:0005111)2.89023695
35Biconcave vertebral bodies (HP:0004586)2.66817102
36Infantile muscular hypotonia (HP:0008947)2.62671605
37Delayed closure of the anterior fontanelle (HP:0001476)2.61604746
38Abnormality of the ischium (HP:0003174)2.60784721
39Abnormal delivery (HP:0001787)2.52687833
40Mesangial abnormality (HP:0001966)2.47963162
41Mitral valve prolapse (HP:0001634)2.47670603
42Delayed cranial suture closure (HP:0000270)2.47197515
43Hyperextensible skin (HP:0000974)2.46854281
44Aortic regurgitation (HP:0001659)2.43257456
45Mesomelia (HP:0003027)2.41116459
46Joint laxity (HP:0001388)2.39566316
47Keratoconus (HP:0000563)2.34942135
48Increased corneal curvature (HP:0100692)2.34942135
49Spinal rigidity (HP:0003306)2.34327086
50Cerebral aneurysm (HP:0004944)2.33079762
51Increased variability in muscle fiber diameter (HP:0003557)2.32917622
52Hypoplasia of the iris (HP:0007676)2.28097739
53Microglossia (HP:0000171)2.27946360
54Turricephaly (HP:0000262)2.27207454
55Delayed gross motor development (HP:0002194)2.27103440
56Morphological abnormality of the middle ear (HP:0008609)2.26596892
57Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.24711212
58Redundant skin (HP:0001582)2.24561473
59Partial duplication of the phalanx of hand (HP:0009999)2.24047704
60Osteolytic defects of the phalanges of the hand (HP:0009771)2.20661860
61Osteolytic defects of the hand bones (HP:0009699)2.20661860
62Mildly elevated creatine phosphokinase (HP:0008180)2.18137023
63Ovoid vertebral bodies (HP:0003300)2.15638185
64Tibial bowing (HP:0002982)2.08727051
65Aplasia of the musculature (HP:0100854)2.06196622
66Osteoarthritis (HP:0002758)2.05603489
67Gingival overgrowth (HP:0000212)2.02966033
68Abnormality of the acetabulum (HP:0003170)2.02702922
69Fibular hypoplasia (HP:0003038)2.02030558
70Aortic valve stenosis (HP:0001650)2.01078549
71Abnormality of the 2nd finger (HP:0004100)1.98954546
72Ulnar bowing (HP:0003031)1.98330281
73Coxa vara (HP:0002812)1.98193449
74Elbow flexion contracture (HP:0002987)1.97152558
75Abnormality of skull ossification (HP:0002703)1.97129888
76Overgrowth (HP:0001548)1.97094848
77Striae distensae (HP:0001065)1.95329811
78Long toe (HP:0010511)1.94970896
79Femoral bowing (HP:0002980)1.94874318
80Metaphyseal dysplasia (HP:0100255)1.93272130
81Deviation of the hallux (HP:0010051)1.92426886
82Protruding ear (HP:0000411)1.91220192
83Decreased skull ossification (HP:0004331)1.90694305
84Coronal craniosynostosis (HP:0004440)1.89612784
85Joint stiffness (HP:0001387)1.89325540
86Ectopia lentis (HP:0001083)1.89209102
87Venous insufficiency (HP:0005293)1.87628431
88Hallux valgus (HP:0001822)1.87372936
89Mitral regurgitation (HP:0001653)1.86092912
90Generalized amyotrophy (HP:0003700)1.85941236
91Sparse lateral eyebrow (HP:0005338)1.82737518
92Limited hip movement (HP:0008800)1.82109169
93Abnormality of the phalanges of the 2nd finger (HP:0009541)1.81361595
94Congenital, generalized hypertrichosis (HP:0004540)1.79919204
95Abnormality of the frontal sinuses (HP:0002687)1.79762838
96Narrow palate (HP:0000189)1.78566440
97Recurrent corneal erosions (HP:0000495)1.76529392
98Vertebral compression fractures (HP:0002953)1.76423559
99Hypoventilation (HP:0002791)1.73535870
100Abnormality of skeletal muscle fiber size (HP:0012084)1.72693242

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR4.91069710
2EPHB24.00241728
3DDR23.71079200
4MYLK3.65725690
5PDGFRA3.56980326
6TRIB33.06207478
7MARK12.82942323
8ABL22.37451673
9WNK32.28572917
10PAK22.27777613
11KIT2.11999643
12SIK12.11419446
13ADRBK22.04378428
14ADRBK11.84008406
15TGFBR21.74509858
16MARK21.69277539
17MAP4K21.66857938
18PDGFRB1.56518493
19MAPK131.51733576
20MAPK151.47351206
21RPS6KA41.44159625
22PAK31.43320843
23AKT31.34386793
24GSK3A1.33924663
25LIMK11.33727035
26NTRK31.28454608
27CDC42BPA1.27484468
28PTK21.26790518
29PRKD21.26568901
30BMPR1B1.20605995
31TAF11.18078518
32ILK1.17552745
33CASK1.08617504
34VRK21.08291408
35MAP3K21.07618898
36NLK1.05082635
37TRPM71.04149554
38NME11.01297567
39STK161.00053669
40MAPKAPK30.98994918
41ERN10.96980825
42PIK3CG0.95038824
43PHKG10.92843895
44PHKG20.92843895
45DYRK20.89432892
46PKN10.88685527
47NEK90.88401005
48NTRK10.87147518
49GRK10.86286636
50MAP2K10.85540699
51ROCK10.85196029
52FRK0.85178639
53CAMKK20.85136559
54TYK20.83627677
55EIF2AK20.80451463
56GRK50.79400222
57MAPKAPK50.79008933
58STK380.78373731
59CLK10.76119493
60STK38L0.75777076
61TGFBR10.74901731
62MET0.73625094
63TESK10.71899412
64PAK60.71880608
65CAMK1D0.67704122
66JAK10.67359846
67CAMK2G0.66739518
68MAPK70.65481543
69PIK3CA0.63162950
70ACVR1B0.60524335
71LATS20.60508575
72LATS10.58390497
73GRK70.57379968
74CAMK2D0.55280971
75STK30.54220268
76MAPK120.53083163
77CDK30.50995911
78CAMK2A0.50319668
79PRKCE0.50124923
80RIPK10.47614760
81CHEK20.41777808
82MAP3K70.41420439
83TTN0.39573512
84PRKG10.39267470
85INSR0.38630696
86HIPK20.37253458
87CAMK10.37032124
88PRKD10.36574135
89SIK20.35480874
90VRK10.35385532
91MAPK40.33797352
92TNIK0.33655963
93KSR20.33099851
94CAMK40.32675721
95PTK2B0.32163977
96MUSK0.28662439
97PAK40.28549021
98ABL10.28245948
99CAMK1G0.28034979
100STK390.25680980

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045125.32717285
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004304.42820692
3Protein digestion and absorption_Homo sapiens_hsa049743.56394541
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.92608670
5Focal adhesion_Homo sapiens_hsa045102.60544178
6Basal cell carcinoma_Homo sapiens_hsa052172.51951321
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.37499462
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.30641225
9Amoebiasis_Homo sapiens_hsa051462.01477145
10Melanoma_Homo sapiens_hsa052182.01296871
11Linoleic acid metabolism_Homo sapiens_hsa005911.93786216
12Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.90149887
13Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.78725949
14Dilated cardiomyopathy_Homo sapiens_hsa054141.75781349
15Proteoglycans in cancer_Homo sapiens_hsa052051.69656201
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.68512758
17Hedgehog signaling pathway_Homo sapiens_hsa043401.63659998
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.62607998
19Vascular smooth muscle contraction_Homo sapiens_hsa042701.61935713
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.59716428
21TGF-beta signaling pathway_Homo sapiens_hsa043501.53585060
22Ether lipid metabolism_Homo sapiens_hsa005651.50576259
23PI3K-Akt signaling pathway_Homo sapiens_hsa041511.42595036
24Malaria_Homo sapiens_hsa051441.34186719
25AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.31044196
26Glycosaminoglycan degradation_Homo sapiens_hsa005311.28758043
27Arachidonic acid metabolism_Homo sapiens_hsa005901.28339619
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.22247110
29Cocaine addiction_Homo sapiens_hsa050301.22187648
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22047183
31Small cell lung cancer_Homo sapiens_hsa052221.20078664
32Hippo signaling pathway_Homo sapiens_hsa043901.17600856
33Nicotine addiction_Homo sapiens_hsa050331.17012316
34Pathways in cancer_Homo sapiens_hsa052001.08581309
35Wnt signaling pathway_Homo sapiens_hsa043101.06165676
36Bladder cancer_Homo sapiens_hsa052191.02805851
37Axon guidance_Homo sapiens_hsa043601.00361850
38Selenocompound metabolism_Homo sapiens_hsa004500.98721183
39Regulation of actin cytoskeleton_Homo sapiens_hsa048100.98563057
40Melanogenesis_Homo sapiens_hsa049160.96642755
41Complement and coagulation cascades_Homo sapiens_hsa046100.94000344
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92702265
43cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87331603
44Prostate cancer_Homo sapiens_hsa052150.85540815
45Ovarian steroidogenesis_Homo sapiens_hsa049130.82708784
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80430357
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79255548
48Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76140808
49Sulfur metabolism_Homo sapiens_hsa009200.74965476
50Platelet activation_Homo sapiens_hsa046110.74883470
51MicroRNAs in cancer_Homo sapiens_hsa052060.73840515
52Gap junction_Homo sapiens_hsa045400.72499819
53Ras signaling pathway_Homo sapiens_hsa040140.71583029
54Calcium signaling pathway_Homo sapiens_hsa040200.71112623
55Adherens junction_Homo sapiens_hsa045200.71012037
56Pertussis_Homo sapiens_hsa051330.70554899
57Sulfur relay system_Homo sapiens_hsa041220.65548960
58Long-term depression_Homo sapiens_hsa047300.58869244
59Cholinergic synapse_Homo sapiens_hsa047250.58759249
60Fat digestion and absorption_Homo sapiens_hsa049750.56171348
61MAPK signaling pathway_Homo sapiens_hsa040100.55964459
62Rap1 signaling pathway_Homo sapiens_hsa040150.55816026
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54778346
64Pancreatic cancer_Homo sapiens_hsa052120.52058710
65Oxytocin signaling pathway_Homo sapiens_hsa049210.51830669
66Toxoplasmosis_Homo sapiens_hsa051450.51522017
67Mineral absorption_Homo sapiens_hsa049780.50199049
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48901270
69Renin secretion_Homo sapiens_hsa049240.48715013
70Amphetamine addiction_Homo sapiens_hsa050310.48680429
71Colorectal cancer_Homo sapiens_hsa052100.47854781
72Choline metabolism in cancer_Homo sapiens_hsa052310.47229384
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44278701
74cAMP signaling pathway_Homo sapiens_hsa040240.43926658
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.42625562
76Glioma_Homo sapiens_hsa052140.42449600
77Morphine addiction_Homo sapiens_hsa050320.42358445
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42144735
79Prion diseases_Homo sapiens_hsa050200.40712471
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39309418
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38336225
82Cardiac muscle contraction_Homo sapiens_hsa042600.38102400
83Chemical carcinogenesis_Homo sapiens_hsa052040.37941796
84One carbon pool by folate_Homo sapiens_hsa006700.37582009
85GABAergic synapse_Homo sapiens_hsa047270.37418635
86Nitrogen metabolism_Homo sapiens_hsa009100.36829419
87Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.36520115
88Glutamatergic synapse_Homo sapiens_hsa047240.36028185
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35843477
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35610903
91Glutathione metabolism_Homo sapiens_hsa004800.34564473
92GnRH signaling pathway_Homo sapiens_hsa049120.33653513
93Alzheimers disease_Homo sapiens_hsa050100.30995155
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.27533810
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.26894355
96Thyroid hormone synthesis_Homo sapiens_hsa049180.26674840
97HTLV-I infection_Homo sapiens_hsa051660.26003869
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.25846776
99Chronic myeloid leukemia_Homo sapiens_hsa052200.25329978
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24727673

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