MXRA5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the matrix-remodelling associated proteins. This protein contains 7 leucine-rich repeats and 12 immunoglobulin-like C2-type domains related to perlecan. This gene has a pseudogene on chromosome Y. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1collagen fibril organization (GO:0030199)6.39621178
2protein heterotrimerization (GO:0070208)6.03836004
3skin morphogenesis (GO:0043589)5.59372123
4sequestering of extracellular ligand from receptor (GO:0035581)5.10664647
5bone trabecula formation (GO:0060346)5.03922113
6cell migration involved in heart development (GO:0060973)4.74644989
7extracellular fibril organization (GO:0043206)4.65863130
8collagen metabolic process (GO:0032963)4.60799429
9collagen catabolic process (GO:0030574)4.56520756
10endodermal cell differentiation (GO:0035987)4.51114068
11multicellular organismal macromolecule metabolic process (GO:0044259)4.34334386
12adhesion of symbiont to host cell (GO:0044650)4.29500267
13virion attachment to host cell (GO:0019062)4.29500267
14multicellular organismal catabolic process (GO:0044243)4.28166785
15fibril organization (GO:0097435)4.17376921
16multicellular organismal metabolic process (GO:0044236)4.13495871
17extracellular matrix assembly (GO:0085029)4.07354912
18cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.07349561
19keratan sulfate catabolic process (GO:0042340)4.01224341
20tooth mineralization (GO:0034505)3.98995837
21extracellular matrix disassembly (GO:0022617)3.92044276
22axon extension involved in axon guidance (GO:0048846)3.87458431
23neuron projection extension involved in neuron projection guidance (GO:1902284)3.87458431
24chondrocyte development (GO:0002063)3.83149094
25mesenchymal-epithelial cell signaling (GO:0060638)3.81057246
26chondrocyte proliferation (GO:0035988)3.78460558
27planar cell polarity pathway involved in neural tube closure (GO:0090179)3.76147274
28metanephric mesenchyme development (GO:0072075)3.74777082
29glomerular basement membrane development (GO:0032836)3.72861673
30basement membrane organization (GO:0071711)3.64937790
31vascular endothelial growth factor signaling pathway (GO:0038084)3.63663718
32adhesion of symbiont to host (GO:0044406)3.63354402
33kidney mesenchyme development (GO:0072074)3.59320487
34regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.53653652
35regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.52546705
36blood vessel maturation (GO:0001955)3.51713338
37negative regulation of chondrocyte differentiation (GO:0032331)3.49373167
38peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.39363532
39extracellular negative regulation of signal transduction (GO:1900116)3.30031929
40extracellular regulation of signal transduction (GO:1900115)3.30031929
41dermatan sulfate biosynthetic process (GO:0030208)3.28437285
42dermatan sulfate metabolic process (GO:0030205)3.27176407
43type B pancreatic cell proliferation (GO:0044342)3.26084697
44extracellular matrix organization (GO:0030198)3.18052293
45glomerular filtration (GO:0003094)3.16892859
46extracellular structure organization (GO:0043062)3.16869806
47negative regulation of fatty acid transport (GO:2000192)3.15639284
48endocardial cushion development (GO:0003197)3.14944079
49Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.14656493
50cell proliferation involved in metanephros development (GO:0072203)3.12769033
51substrate-dependent cell migration (GO:0006929)3.08982830
52negative regulation of smooth muscle cell migration (GO:0014912)3.08862868
53regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.07122487
54smooth muscle tissue development (GO:0048745)3.05695020
55embryonic cranial skeleton morphogenesis (GO:0048701)3.04829601
56regulation of establishment of planar polarity (GO:0090175)3.03638235
57regulation of extracellular matrix disassembly (GO:0010715)3.02461760
58endothelial cell morphogenesis (GO:0001886)3.01754952
59renal filtration (GO:0097205)2.99877980
60desmosome organization (GO:0002934)2.98654607
61cellular response to vitamin (GO:0071295)2.98536626
62establishment of tissue polarity (GO:0007164)2.96850232
63establishment of planar polarity (GO:0001736)2.96850232
64positive regulation of endothelial cell apoptotic process (GO:2000353)2.90220263
65cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.88294468
66cell adhesion mediated by integrin (GO:0033627)2.88133678
67wound healing, spreading of epidermal cells (GO:0035313)2.82604115
68negative regulation of cartilage development (GO:0061037)2.81739551
69regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.80595622
70pericardium development (GO:0060039)2.76556838
71positive regulation of osteoblast proliferation (GO:0033690)2.76536012
72regulation of axon extension involved in axon guidance (GO:0048841)2.76278730
73negative regulation of BMP signaling pathway (GO:0030514)2.75967405
74cell migration involved in sprouting angiogenesis (GO:0002042)2.74554303
75negative regulation of axon extension involved in axon guidance (GO:0048843)2.73609208
76hemidesmosome assembly (GO:0031581)2.73578944
77cellular response to amino acid stimulus (GO:0071230)2.70926288
78regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.68591508
79middle ear morphogenesis (GO:0042474)2.68444555
80cochlea morphogenesis (GO:0090103)2.66774401
81non-canonical Wnt signaling pathway (GO:0035567)2.65781287
82positive regulation of mesenchymal cell proliferation (GO:0002053)2.65635180
83muscle cell migration (GO:0014812)2.65509945
84cellular response to vitamin D (GO:0071305)2.63392800
85negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.62400536
86negative regulation of embryonic development (GO:0045992)2.61546211
87outer ear morphogenesis (GO:0042473)2.60803314
88positive regulation of smoothened signaling pathway (GO:0045880)2.60232215
89cell-substrate junction assembly (GO:0007044)2.57355428
90face morphogenesis (GO:0060325)2.57228931
91negative chemotaxis (GO:0050919)2.56861132
92protein localization to cell surface (GO:0034394)2.55480374
93wound healing (GO:0042060)2.54655947
94apoptotic cell clearance (GO:0043277)2.52083998
95substrate adhesion-dependent cell spreading (GO:0034446)2.51932032
96barbed-end actin filament capping (GO:0051016)2.50231900
97regulation of chemokine-mediated signaling pathway (GO:0070099)2.47426126
98regulation of axon guidance (GO:1902667)2.47220304
99peptide cross-linking (GO:0018149)2.46958739
100craniofacial suture morphogenesis (GO:0097094)2.46844380

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.99436189
2PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.19838581
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.61707419
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.53937015
5ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.68449646
6TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.30984675
7RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.16144563
8* CJUN_26792858_Chip-Seq_BT549_Human2.08158236
9CDX2_19796622_ChIP-Seq_MESCs_Mouse2.06830425
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.05148522
11CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.03163480
12WT1_19549856_ChIP-ChIP_CCG9911_Human2.02421450
13CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.01778580
14EP300_21415370_ChIP-Seq_HL-1_Mouse1.96832639
15ZNF217_24962896_ChIP-Seq_MCF-7_Human1.93989502
16BRD4_25478319_ChIP-Seq_HGPS_Human1.92662289
17EED_16625203_ChIP-ChIP_MESCs_Mouse1.92513952
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.90530337
19WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.85134744
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.80630055
21EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.78651872
22ESR2_21235772_ChIP-Seq_MCF-7_Human1.76501159
23ESR1_21235772_ChIP-Seq_MCF-7_Human1.76300276
24CLOCK_20551151_ChIP-Seq_293T_Human1.73814699
25EZH2_18974828_ChIP-Seq_MESCs_Mouse1.71392526
26RNF2_18974828_ChIP-Seq_MESCs_Mouse1.71392526
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.66409129
28SOX9_24532713_ChIP-Seq_HFSC_Mouse1.63702601
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.63107942
30SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.60847923
31TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.57500759
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.57219592
33NRF2_20460467_ChIP-Seq_MEFs_Mouse1.56686932
34NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.56686932
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.49021575
36TP53_18474530_ChIP-ChIP_U2OS_Human1.47126175
37SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.43826442
38NFIB_24661679_ChIP-Seq_LUNG_Mouse1.41327149
39JARID2_20075857_ChIP-Seq_MESCs_Mouse1.36989376
40AHR_22903824_ChIP-Seq_MCF-7_Human1.34418671
41SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.34145161
42PPAR_26484153_Chip-Seq_NCI-H1993_Human1.32581620
43RNF2_27304074_Chip-Seq_ESCs_Mouse1.31996483
44TP53_16413492_ChIP-PET_HCT116_Human1.31176756
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29754872
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.29598113
47EZH2_27304074_Chip-Seq_ESCs_Mouse1.29502257
48SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.28917413
49MTF2_20144788_ChIP-Seq_MESCs_Mouse1.28780594
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26760941
51ISL1_27105846_Chip-Seq_CPCs_Mouse1.25433812
52SMC1_22415368_ChIP-Seq_MEFs_Mouse1.25312631
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.25147495
54WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24813328
55TP53_20018659_ChIP-ChIP_R1E_Mouse1.24675223
56GATA2_21666600_ChIP-Seq_HMVEC_Human1.23336237
57SA1_22415368_ChIP-Seq_MEFs_Mouse1.20014140
58TBX20_22080862_ChIP-Seq_HEART_Mouse1.18638115
59TBX20_22328084_ChIP-Seq_HEART_Mouse1.18638115
60ELK3_25401928_ChIP-Seq_HUVEC_Human1.17959315
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16602660
62ARNT_22903824_ChIP-Seq_MCF-7_Human1.15975930
63ESR1_20079471_ChIP-ChIP_T-47D_Human1.13721872
64P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13453507
65SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.12625128
66SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.12625128
67HIF1A_21447827_ChIP-Seq_MCF-7_Human1.11432442
68NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.10719450
69SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.09510316
70FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.06415919
71CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06018901
72* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05329233
73PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.04653610
74DROSHA_22980978_ChIP-Seq_HELA_Human1.03425503
75SMC3_22415368_ChIP-Seq_MEFs_Mouse1.03191882
76P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02694138
77TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02650295
78DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02338440
79MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01327949
80JARID2_20064375_ChIP-Seq_MESCs_Mouse1.00443664
81KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99647845
82TP53_23651856_ChIP-Seq_MEFs_Mouse0.99298200
83JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98692575
84* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.98672038
85JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97477828
86BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97146122
87ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96586787
88KDM2B_26808549_Chip-Seq_K562_Human0.96384939
89UBF1/2_26484160_Chip-Seq_HMECs_Human0.96140979
90RING1B_27294783_Chip-Seq_ESCs_Mouse0.95165589
91SOX2_20726797_ChIP-Seq_SW620_Human0.94703692
92SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93025415
93UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.90549841
94SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90541340
95EZH2_27294783_Chip-Seq_ESCs_Mouse0.89366507
96TCF4_18268006_ChIP-ChIP_LS174T_Human0.89036198
97RACK7_27058665_Chip-Seq_MCF-7_Human0.88923681
98* TP63_23658742_ChIP-Seq_EP156T_Human0.87985419
99SUZ12_27294783_Chip-Seq_ESCs_Mouse0.86142570
100ZFP281_27345836_Chip-Seq_ESCs_Mouse0.85907743

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen8.70963727
2MP0005503_abnormal_tendon_morphology7.16948646
3MP0005275_abnormal_skin_tensile6.67337447
4MP0003705_abnormal_hypodermis_morpholog3.85957030
5MP0003279_aneurysm3.74935877
6MP0001958_emphysema3.54645086
7MP0004272_abnormal_basement_membrane3.31509947
8MP0005257_abnormal_intraocular_pressure3.14926888
9MP0006054_spinal_hemorrhage2.72016190
10MP0002108_abnormal_muscle_morphology2.49305361
11MP0001542_abnormal_bone_strength2.48671670
12MP0009384_cardiac_valve_regurgitation2.40824152
13MP0005508_abnormal_skeleton_morphology2.30743501
14MP0002060_abnormal_skin_morphology2.22996374
15MP0003566_abnormal_cell_adhesion1.93557610
16MP0000751_myopathy1.86608838
17MP0005023_abnormal_wound_healing1.80884957
18MP0002295_abnormal_pulmonary_circulatio1.68163630
19MP0001243_abnormal_dermal_layer1.67366085
20MP0009250_abnormal_appendicular_skeleto1.66569491
21MP0010368_abnormal_lymphatic_system1.65890757
22MP0000767_abnormal_smooth_muscle1.59288010
23MP0002896_abnormal_bone_mineralization1.56598181
24MP0003941_abnormal_skin_development1.54300356
25MP0009780_abnormal_chondrocyte_physiolo1.48185123
26MP0003091_abnormal_cell_migration1.38682159
27MP0010030_abnormal_orbit_morphology1.35349233
28MP0005390_skeleton_phenotype1.26827520
29MP0004858_abnormal_nervous_system1.25864445
30MP0000534_abnormal_ureter_morphology1.23424313
31MP0000013_abnormal_adipose_tissue1.17283484
32MP0010352_gastrointestinal_tract_polyps1.15420979
33MP0002115_abnormal_skeleton_extremities1.12317949
34MP0003283_abnormal_digestive_organ1.12094512
35MP0000428_abnormal_craniofacial_morphol1.11473214
36MP0004134_abnormal_chest_morphology1.09795909
37MP0001299_abnormal_eye_distance/1.08077487
38MP0000163_abnormal_cartilage_morphology1.07242777
39MP0003385_abnormal_body_wall1.06605305
40MP0005623_abnormal_meninges_morphology1.06596888
41MP0000049_abnormal_middle_ear1.03690652
42MP0002796_impaired_skin_barrier1.03051835
43MP0003942_abnormal_urinary_system1.02686458
44MP0000462_abnormal_digestive_system1.02215660
45MP0001348_abnormal_lacrimal_gland1.00132724
46MP0001849_ear_inflammation0.97454649
47MP0000733_abnormal_muscle_development0.93540863
48MP0005171_absent_coat_pigmentation0.93472507
49MP0010386_abnormal_urinary_bladder0.92641586
50MP0002933_joint_inflammation0.92216279
51MP0000432_abnormal_head_morphology0.92207976
52MP0000762_abnormal_tongue_morphology0.88985182
53MP0005595_abnormal_vascular_smooth0.88534772
54MP0002282_abnormal_trachea_morphology0.85681232
55MP0002113_abnormal_skeleton_development0.82640695
56MP0002249_abnormal_larynx_morphology0.80668645
57MP0002932_abnormal_joint_morphology0.79519971
58MP0009053_abnormal_anal_canal0.77709555
59MP0002116_abnormal_craniofacial_bone0.76236462
60MP0005388_respiratory_system_phenotype0.75533555
61MP0002133_abnormal_respiratory_system0.75533555
62MP0003300_gastrointestinal_ulcer0.75464943
63MP0001879_abnormal_lymphatic_vessel0.75456762
64MP0005409_darkened_coat_color0.75193593
65MP0002998_abnormal_bone_remodeling0.73866685
66MP0003115_abnormal_respiratory_system0.72990888
67MP0010771_integument_phenotype0.72917968
68MP0002168_other_aberrant_phenotype0.70824261
69MP0003795_abnormal_bone_structure0.70747691
70MP0002109_abnormal_limb_morphology0.70467551
71MP0002128_abnormal_blood_circulation0.70348772
72MP0003448_altered_tumor_morphology0.70079956
73MP0003950_abnormal_plasma_membrane0.69547951
74MP0000467_abnormal_esophagus_morphology0.68548562
75MP0000759_abnormal_skeletal_muscle0.67111468
76MP0005164_abnormal_response_to0.65664756
77MP0002114_abnormal_axial_skeleton0.65349683
78MP0003935_abnormal_craniofacial_develop0.65092963
79MP0003755_abnormal_palate_morphology0.64991181
80MP0001614_abnormal_blood_vessel0.64489483
81MP0000003_abnormal_adipose_tissue0.64041352
82MP0005369_muscle_phenotype0.63829699
83MP0001175_abnormal_lung_morphology0.63774504
84MP0002254_reproductive_system_inflammat0.60656789
85MP0000538_abnormal_urinary_bladder0.60452571
86MP0002877_abnormal_melanocyte_morpholog0.57399538
87MP0005076_abnormal_cell_differentiation0.57241193
88MP0005501_abnormal_skin_physiology0.55537561
89MP0003045_fibrosis0.54638641
90MP0000681_abnormal_thyroid_gland0.54488407
91MP0005197_abnormal_uvea_morphology0.52651973
92MP0008004_abnormal_stomach_pH0.51993141
93MP0003937_abnormal_limbs/digits/tail_de0.51841942
94MP0002925_abnormal_cardiovascular_devel0.49860526
95MP0001533_abnormal_skeleton_physiology0.48160423
96MP0000579_abnormal_nail_morphology0.48067144
97MP0002233_abnormal_nose_morphology0.47966847
98MP0001177_atelectasis0.47577141
99MP0004883_abnormal_blood_vessel0.46508774
100MP0002177_abnormal_outer_ear0.46239416

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)7.50746941
2Protrusio acetabuli (HP:0003179)7.16126734
3Aortic dissection (HP:0002647)5.52309844
4Soft skin (HP:0000977)4.79719707
5Aortic aneurysm (HP:0004942)4.77100010
6Atrophic scars (HP:0001075)4.56534948
7Bladder diverticulum (HP:0000015)4.53995223
8Neonatal short-limb short stature (HP:0008921)4.22992289
9Vascular tortuosity (HP:0004948)4.16842724
10Fragile skin (HP:0001030)4.09147108
11Broad metatarsal (HP:0001783)4.05970047
12Ankle contracture (HP:0006466)4.00161962
13Genu recurvatum (HP:0002816)3.89015007
14Peritonitis (HP:0002586)3.84282749
15Follicular hyperkeratosis (HP:0007502)3.72790654
16Shallow orbits (HP:0000586)3.70557317
17Dilatation of the ascending aorta (HP:0005111)3.58353099
18Cervical subluxation (HP:0003308)3.54081762
19Type 1 muscle fiber predominance (HP:0003803)3.52369197
20Abnormality of dentin (HP:0010299)3.46855069
21Arterial tortuosity (HP:0005116)3.41583453
22Wormian bones (HP:0002645)3.38036502
23Mitral valve prolapse (HP:0001634)3.25761409
24Mild short stature (HP:0003502)3.24799878
25Blue sclerae (HP:0000592)3.10656708
26Bowel diverticulosis (HP:0005222)3.10227566
27Spondylolisthesis (HP:0003302)3.05683435
28Cerebral aneurysm (HP:0004944)3.02808484
29Biconcave vertebral bodies (HP:0004586)3.00451399
30Wide anterior fontanel (HP:0000260)2.99081937
31Spinal rigidity (HP:0003306)2.94913872
32Osteolytic defects of the phalanges of the hand (HP:0009771)2.87976864
33Osteolytic defects of the hand bones (HP:0009699)2.87976864
34Overgrowth (HP:0001548)2.87924879
35Hyperextensible skin (HP:0000974)2.84381416
36Joint laxity (HP:0001388)2.83073792
37Slender build (HP:0001533)2.81512515
38Absent frontal sinuses (HP:0002688)2.75441355
39Vertebral compression fractures (HP:0002953)2.66791175
40Increased variability in muscle fiber diameter (HP:0003557)2.51666426
41Aortic regurgitation (HP:0001659)2.50865647
42Infantile muscular hypotonia (HP:0008947)2.48227610
43Mildly elevated creatine phosphokinase (HP:0008180)2.44795392
44Abnormal delivery (HP:0001787)2.43379725
45Abnormality of the acetabulum (HP:0003170)2.38331642
46Osteoarthritis (HP:0002758)2.36413347
47Breech presentation (HP:0001623)2.36182294
48Aneurysm (HP:0002617)2.35705439
49Ectopia lentis (HP:0001083)2.35499540
50Mitral regurgitation (HP:0001653)2.35027626
51Thin bony cortex (HP:0002753)2.34824577
52Ulnar bowing (HP:0003031)2.32500000
53Round ear (HP:0100830)2.27678235
54Morphological abnormality of the middle ear (HP:0008609)2.26000636
55Aortic valve stenosis (HP:0001650)2.19220442
56Natal tooth (HP:0000695)2.18948659
57Coronal craniosynostosis (HP:0004440)2.18662347
58Wrist flexion contracture (HP:0001239)2.18457066
59Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.17770073
60Nonimmune hydrops fetalis (HP:0001790)2.12882454
61Joint stiffness (HP:0001387)2.11989483
62Tibial bowing (HP:0002982)2.07567629
63Broad ribs (HP:0000885)2.07522798
64Abnormality of skeletal muscle fiber size (HP:0012084)2.05844957
65Increased connective tissue (HP:0009025)2.05358682
66Deviation of the hallux (HP:0010051)2.01892211
67Hallux valgus (HP:0001822)1.97198693
68Elbow flexion contracture (HP:0002987)1.94873256
69Femoral bowing (HP:0002980)1.93521372
70Mitral stenosis (HP:0001718)1.93410782
71Alopecia of scalp (HP:0002293)1.92802159
72Striae distensae (HP:0001065)1.92638544
73Broad long bones (HP:0005622)1.92042861
74Delayed cranial suture closure (HP:0000270)1.91881362
75Limited hip movement (HP:0008800)1.90876784
76Persistence of primary teeth (HP:0006335)1.90676202
77Abnormality of skull ossification (HP:0002703)1.88215774
78Hypoplasia of the iris (HP:0007676)1.86841478
79Inguinal hernia (HP:0000023)1.86610488
80Ulnar deviation of the wrist (HP:0003049)1.86449463
81Disproportionate tall stature (HP:0001519)1.86040600
82Cupped ribs (HP:0000887)1.83864650
83Venous abnormality (HP:0002624)1.79796425
84Hypoventilation (HP:0002791)1.79684240
85Camptodactyly of toe (HP:0001836)1.78659853
86Ovoid vertebral bodies (HP:0003300)1.77972774
87Venous insufficiency (HP:0005293)1.76529803
88Coxa vara (HP:0002812)1.76109925
89Delayed closure of the anterior fontanelle (HP:0001476)1.75345957
90Narrow nasal bridge (HP:0000446)1.73288458
91Decreased skull ossification (HP:0004331)1.73203555
92Syringomyelia (HP:0003396)1.72388448
93Spinal cord lesions (HP:0100561)1.72388448
94Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.71828410
95Sparse lateral eyebrow (HP:0005338)1.71255986
96Abnormality of the frontal sinuses (HP:0002687)1.70192538
97Turricephaly (HP:0000262)1.69148264
98Protruding ear (HP:0000411)1.68813663
99Asymmetry of the thorax (HP:0001555)1.68567969
100Advanced eruption of teeth (HP:0006288)1.68109161

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDGFRA4.51595853
2MYLK4.21591650
3DDR23.88341962
4RIPK13.25193397
5TRIB32.84405152
6ERN12.49225512
7AKT32.46146787
8NEK92.37730788
9LATS12.37653374
10TTN2.25995078
11EPHB22.23657158
12CDC42BPA1.99218098
13PDGFRB1.97953030
14PTK21.95792336
15FGFR41.94613699
16NTRK11.90111179
17TGFBR21.89251649
18PAK21.87853763
19KIT1.81557768
20SIK11.79144771
21MET1.65925092
22EPHA31.62429369
23LATS21.55266206
24TESK11.52029660
25PRKD21.48699586
26MST1R1.45767653
27PAK41.45099575
28MAP3K61.41521304
29PKN21.36548607
30DMPK1.32994195
31MAPK71.30879197
32RPS6KA21.26210776
33PIK3CG1.23783408
34TRPM71.22593229
35EPHB11.21029795
36EEF2K1.20445475
37STK381.20159668
38MTOR1.12762615
39CDK121.10017072
40EPHA21.07422185
41FER1.02652476
42ICK0.98122689
43JAK10.94766024
44FGFR30.91050980
45PIK3CA0.88604805
46ROCK10.88481750
47TYK20.87867617
48STK38L0.83362595
49ABL20.83076297
50RPS6KC10.82220187
51RPS6KL10.82220187
52LIMK10.81538591
53ERBB40.80884318
54TGFBR10.79899851
55MARK20.79708311
56ROCK20.77055855
57MAP3K70.76905195
58STK30.72909664
59ADRBK10.70963858
60RET0.69921736
61NLK0.69644967
62MAPKAPK30.66389145
63HIPK20.65864106
64RPS6KA60.64419717
65ILK0.63176412
66PRKD10.63155958
67WNK10.62230439
68FLT30.61140761
69CAMK1G0.58383197
70PTK60.57658813
71MAP2K10.56947105
72SMG10.54694463
73GSK3A0.53353212
74PRKG20.51591413
75MELK0.49101217
76FGFR10.49076874
77MAP3K20.45635563
78BMX0.45196499
79MAPKAPK20.44444598
80PAK30.41037248
81CDK60.41005726
82PTK2B0.39144589
83MAP3K100.38610287
84LMTK20.38453468
85SRC0.38128584
86CHUK0.37594705
87MOS0.37579030
88PRKCE0.37280153
89MAPK40.36688958
90PRKD30.33810454
91MAPK10.33435226
92SGK30.32148584
93ABL10.32043264
94MAP3K30.31868761
95CAMK2G0.31109258
96JAK30.31089912
97TYRO30.30785016
98PRPF4B0.30047298
99ERBB20.29903718
100MAP3K120.28709917

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.54585497
2Protein digestion and absorption_Homo sapiens_hsa049743.47243751
3Focal adhesion_Homo sapiens_hsa045103.04530462
4Amoebiasis_Homo sapiens_hsa051462.29956018
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.18966734
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.05020840
7Proteoglycans in cancer_Homo sapiens_hsa052051.95417417
8Dilated cardiomyopathy_Homo sapiens_hsa054141.86612521
9AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.82840991
10Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.81198534
11Glycosaminoglycan degradation_Homo sapiens_hsa005311.71749203
12Adherens junction_Homo sapiens_hsa045201.68601076
13Malaria_Homo sapiens_hsa051441.57069119
14Basal cell carcinoma_Homo sapiens_hsa052171.52188117
15Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.51742345
16PI3K-Akt signaling pathway_Homo sapiens_hsa041511.44604053
17Hedgehog signaling pathway_Homo sapiens_hsa043401.40243328
18Small cell lung cancer_Homo sapiens_hsa052221.40087527
19Melanoma_Homo sapiens_hsa052181.39684589
20Regulation of actin cytoskeleton_Homo sapiens_hsa048101.38840170
21TGF-beta signaling pathway_Homo sapiens_hsa043501.25908117
22Prostate cancer_Homo sapiens_hsa052151.24090499
23Melanogenesis_Homo sapiens_hsa049161.23568575
24MicroRNAs in cancer_Homo sapiens_hsa052061.23557530
25Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.22397621
26Axon guidance_Homo sapiens_hsa043601.18968426
27Bladder cancer_Homo sapiens_hsa052191.18512445
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.14055242
29Hippo signaling pathway_Homo sapiens_hsa043901.13011973
30Glioma_Homo sapiens_hsa052141.09734765
31Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.09317790
32Pathways in cancer_Homo sapiens_hsa052001.08670927
33Vascular smooth muscle contraction_Homo sapiens_hsa042701.05409684
34Notch signaling pathway_Homo sapiens_hsa043301.05179253
35Renin-angiotensin system_Homo sapiens_hsa046141.04589762
36Tight junction_Homo sapiens_hsa045301.02570320
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.02424393
38Complement and coagulation cascades_Homo sapiens_hsa046100.98874044
39Phospholipase D signaling pathway_Homo sapiens_hsa040720.98688407
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.98484464
41Chronic myeloid leukemia_Homo sapiens_hsa052200.96993391
42Other glycan degradation_Homo sapiens_hsa005110.96757398
43Platelet activation_Homo sapiens_hsa046110.96531681
44cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95411817
45Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93024350
46Gap junction_Homo sapiens_hsa045400.92271048
47Estrogen signaling pathway_Homo sapiens_hsa049150.90654123
48Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88166947
49Rap1 signaling pathway_Homo sapiens_hsa040150.88165800
50Thyroid cancer_Homo sapiens_hsa052160.87622700
51Wnt signaling pathway_Homo sapiens_hsa043100.85561694
52Thyroid hormone synthesis_Homo sapiens_hsa049180.82411974
53Pertussis_Homo sapiens_hsa051330.80885729
54Endometrial cancer_Homo sapiens_hsa052130.79815717
55GnRH signaling pathway_Homo sapiens_hsa049120.79797225
56Pancreatic cancer_Homo sapiens_hsa052120.79284853
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.78848695
58Renal cell carcinoma_Homo sapiens_hsa052110.78321709
59Toxoplasmosis_Homo sapiens_hsa051450.77480043
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73830174
61Renin secretion_Homo sapiens_hsa049240.72503114
62Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71877443
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70149976
64Choline metabolism in cancer_Homo sapiens_hsa052310.69836519
65Lysosome_Homo sapiens_hsa041420.69288710
66Ras signaling pathway_Homo sapiens_hsa040140.68409252
67Prolactin signaling pathway_Homo sapiens_hsa049170.65500923
68Dorso-ventral axis formation_Homo sapiens_hsa043200.65304710
69Prion diseases_Homo sapiens_hsa050200.64437884
70Staphylococcus aureus infection_Homo sapiens_hsa051500.63385783
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62241880
72Acute myeloid leukemia_Homo sapiens_hsa052210.60781307
73TNF signaling pathway_Homo sapiens_hsa046680.60464840
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.59905857
75Endocytosis_Homo sapiens_hsa041440.59376520
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58844527
77Pancreatic secretion_Homo sapiens_hsa049720.56726602
78Phagosome_Homo sapiens_hsa041450.55540451
79mTOR signaling pathway_Homo sapiens_hsa041500.54541006
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52923472
81Hepatitis C_Homo sapiens_hsa051600.51728598
82Insulin resistance_Homo sapiens_hsa049310.51066506
83Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51010168
84AMPK signaling pathway_Homo sapiens_hsa041520.50910979
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47554161
86Gastric acid secretion_Homo sapiens_hsa049710.47517061
87ErbB signaling pathway_Homo sapiens_hsa040120.47456320
88cAMP signaling pathway_Homo sapiens_hsa040240.47057810
89HTLV-I infection_Homo sapiens_hsa051660.46089256
90Colorectal cancer_Homo sapiens_hsa052100.43144178
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42737701
92Hepatitis B_Homo sapiens_hsa051610.42736742
93Oxytocin signaling pathway_Homo sapiens_hsa049210.42330640
94MAPK signaling pathway_Homo sapiens_hsa040100.42028029
95Vibrio cholerae infection_Homo sapiens_hsa051100.41354585
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.41126420
97Cocaine addiction_Homo sapiens_hsa050300.41083032
98VEGF signaling pathway_Homo sapiens_hsa043700.40251950
99Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38890802
100Non-small cell lung cancer_Homo sapiens_hsa052230.38698422

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