MXD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)6.66753431
2translational termination (GO:0006415)6.40917956
3ribosomal small subunit biogenesis (GO:0042274)6.05608152
4ribosomal small subunit assembly (GO:0000028)5.72159717
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.54719300
6cotranslational protein targeting to membrane (GO:0006613)5.51701826
7protein targeting to ER (GO:0045047)5.45708179
8translational elongation (GO:0006414)5.27578665
9establishment of protein localization to endoplasmic reticulum (GO:0072599)5.20040242
10cellular protein complex disassembly (GO:0043624)5.14074815
11protein localization to endoplasmic reticulum (GO:0070972)5.09658705
12viral life cycle (GO:0019058)5.00168135
13ribosomal large subunit biogenesis (GO:0042273)4.97631620
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.86237415
15maturation of SSU-rRNA (GO:0030490)4.78630022
16translational initiation (GO:0006413)4.76018453
17telomere maintenance via semi-conservative replication (GO:0032201)4.62854956
18protein complex disassembly (GO:0043241)4.52645353
19DNA strand elongation involved in DNA replication (GO:0006271)4.31995936
20macromolecular complex disassembly (GO:0032984)4.28715424
21mitotic chromosome condensation (GO:0007076)4.24300116
22chromosome condensation (GO:0030261)4.22779367
23DNA replication checkpoint (GO:0000076)4.10483549
24DNA strand elongation (GO:0022616)4.08451767
25telomere maintenance via recombination (GO:0000722)4.05015455
26CENP-A containing nucleosome assembly (GO:0034080)4.02669289
27chromatin remodeling at centromere (GO:0031055)3.98426053
28antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.96361114
29mitotic recombination (GO:0006312)3.95945627
30DNA ligation (GO:0006266)3.93109295
31translation (GO:0006412)3.92606647
32kinetochore organization (GO:0051383)3.88508403
33proteasome assembly (GO:0043248)3.85637209
34positive regulation by symbiont of host defense response (GO:0052509)3.85395027
35modulation by symbiont of host defense response (GO:0052031)3.85395027
36modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.85395027
37modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.85395027
38positive regulation by organism of defense response of other organism involved in symbiotic interact3.85395027
39modulation by symbiont of host immune response (GO:0052553)3.85395027
40response to peptidoglycan (GO:0032494)3.83794099
41DNA packaging (GO:0006323)3.80903460
42nucleotide-excision repair, DNA gap filling (GO:0006297)3.79701685
43termination of RNA polymerase III transcription (GO:0006386)3.75073313
44transcription elongation from RNA polymerase III promoter (GO:0006385)3.75073313
45sister chromatid segregation (GO:0000819)3.70466493
46kinetochore assembly (GO:0051382)3.69752203
47spliceosomal complex assembly (GO:0000245)3.66440268
48nuclear-transcribed mRNA catabolic process (GO:0000956)3.59481416
49leukocyte migration involved in inflammatory response (GO:0002523)3.58258371
50telomere maintenance via telomere lengthening (GO:0010833)3.56336776
51GTP biosynthetic process (GO:0006183)3.55655344
52DNA replication initiation (GO:0006270)3.52938371
53DNA deamination (GO:0045006)3.52702369
54protein targeting to membrane (GO:0006612)3.49184901
55deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.48824514
56leukocyte aggregation (GO:0070486)3.48057009
57spliceosomal snRNP assembly (GO:0000387)3.47590935
58mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.45831637
59mRNA catabolic process (GO:0006402)3.41820154
60DNA replication-independent nucleosome organization (GO:0034724)3.38699457
61DNA replication-independent nucleosome assembly (GO:0006336)3.38699457
62ribonucleoprotein complex biogenesis (GO:0022613)3.37229919
63energy coupled proton transport, down electrochemical gradient (GO:0015985)3.37006969
64ATP synthesis coupled proton transport (GO:0015986)3.37006969
65detection of other organism (GO:0098543)3.36996685
66detection of bacterium (GO:0016045)3.35304742
67transcription-coupled nucleotide-excision repair (GO:0006283)3.25774760
68positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.24903471
69microtubule depolymerization (GO:0007019)3.23963665
70rRNA methylation (GO:0031167)3.22465831
71RNA catabolic process (GO:0006401)3.21652125
72DNA damage response, detection of DNA damage (GO:0042769)3.20899462
73respiratory burst (GO:0045730)3.20627801
74rRNA modification (GO:0000154)3.20405516
75UTP biosynthetic process (GO:0006228)3.18386312
76rRNA processing (GO:0006364)3.17469359
77negative regulation of cell killing (GO:0031342)3.16412618
78negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.16412618
79chaperone-mediated protein transport (GO:0072321)3.15731963
80neutrophil activation involved in immune response (GO:0002283)3.13815048
81negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.11823617
82deoxyribose phosphate biosynthetic process (GO:0046385)3.10721604
832-deoxyribonucleotide biosynthetic process (GO:0009265)3.10721604
84DNA topological change (GO:0006265)3.10284476
85regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.08248609
86mitotic sister chromatid segregation (GO:0000070)3.06730668
87deoxyribonucleotide biosynthetic process (GO:0009263)3.06141772
88exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.03437124
89rRNA metabolic process (GO:0016072)3.03360883
90attachment of spindle microtubules to kinetochore (GO:0008608)3.00561693
91regulation of interferon-beta biosynthetic process (GO:0045357)2.98088152
92DNA unwinding involved in DNA replication (GO:0006268)2.98066473
93protein localization to kinetochore (GO:0034501)2.97985052
94chromosome segregation (GO:0007059)2.97782669
95nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.97408998
96anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.95911983
97regulation of double-strand break repair via homologous recombination (GO:0010569)2.95359745
98protein localization to chromosome, centromeric region (GO:0071459)2.93585563
99histone exchange (GO:0043486)2.93375309
100establishment of integrated proviral latency (GO:0075713)2.92068931
101mitotic metaphase plate congression (GO:0007080)2.91920593
102macrophage activation involved in immune response (GO:0002281)2.90212483
103negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.89271335
104negative regulation of ligase activity (GO:0051352)2.89271335
105pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.87335217
106mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.85788908
107viral mRNA export from host cell nucleus (GO:0046784)2.85563539
108DNA catabolic process, exonucleolytic (GO:0000738)2.85277749
109antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.85240499
110regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.85229944
111cellular component biogenesis (GO:0044085)2.84690904
112regulation of spindle organization (GO:0090224)2.84336538
113positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.84292128
114pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.84210478
115DNA replication-dependent nucleosome assembly (GO:0006335)2.83938390
116DNA replication-dependent nucleosome organization (GO:0034723)2.83938390
117detection of external biotic stimulus (GO:0098581)2.83371052
118antigen processing and presentation of endogenous antigen (GO:0019883)2.82785784
119pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.79824420
1207-methylguanosine mRNA capping (GO:0006370)2.77681975
121positive regulation of gamma-delta T cell activation (GO:0046645)2.77272633
122pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.74693632
123RNA capping (GO:0036260)2.74562543
1247-methylguanosine RNA capping (GO:0009452)2.74562543
125negative regulation of B cell apoptotic process (GO:0002903)2.73839114
126CTP biosynthetic process (GO:0006241)2.71589403
127CTP metabolic process (GO:0046036)2.71589403
128immunoglobulin mediated immune response (GO:0016064)2.71047926
129response to host immune response (GO:0052572)2.69892383
130response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.69892383
131establishment of protein localization to mitochondrial membrane (GO:0090151)2.69512774
132guanosine-containing compound biosynthetic process (GO:1901070)2.68488560
133protoporphyrinogen IX metabolic process (GO:0046501)2.67641172
134protein neddylation (GO:0045116)2.67346460
135establishment of chromosome localization (GO:0051303)2.66167034
136histone mRNA metabolic process (GO:0008334)2.66091996
137regulation of mitochondrial translation (GO:0070129)2.65986786
138regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.65913010
139intra-S DNA damage checkpoint (GO:0031573)2.64014666
140cellular extravasation (GO:0045123)2.64010087
141meiotic chromosome segregation (GO:0045132)2.63945148
142antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.61803313
143mitotic nuclear envelope reassembly (GO:0007084)2.61574608
144nuclear envelope reassembly (GO:0031468)2.61574608
145detection of biotic stimulus (GO:0009595)2.60544899
146detection of molecule of bacterial origin (GO:0032490)2.56124548
147metaphase plate congression (GO:0051310)2.55892689
148histone-serine phosphorylation (GO:0035404)2.55822217
149negative regulation of interleukin-12 production (GO:0032695)2.55777854
150negative regulation of phagocytosis (GO:0050765)2.52440911
151positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.52144027
152negative regulation of chromosome segregation (GO:0051985)2.49596566
153deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.44891176
154neutrophil activation (GO:0042119)2.44358888
155regulation of mast cell degranulation (GO:0043304)2.44353078

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.67006692
2* SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.88705424
3* FOXM1_23109430_ChIP-Seq_U2OS_Human4.60757314
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.29434512
5E2F4_17652178_ChIP-ChIP_JURKAT_Human4.11796670
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.74313976
7* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.72218901
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.45391369
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.37084865
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.33638165
11* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.14326024
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.07544321
13ETS1_20019798_ChIP-Seq_JURKAT_Human3.07398946
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.03888868
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.94877250
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.92410924
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.88326459
18* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.68708301
19* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.62086244
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.61697411
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.60377345
22XRN2_22483619_ChIP-Seq_HELA_Human2.45707827
23VDR_23849224_ChIP-Seq_CD4+_Human2.44839895
24* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.42109256
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.40923933
26MYC_22102868_ChIP-Seq_BL_Human2.31162008
27* DCP1A_22483619_ChIP-Seq_HELA_Human2.29754504
28TTF2_22483619_ChIP-Seq_HELA_Human2.25188549
29TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.18065215
30FOXP3_21729870_ChIP-Seq_TREG_Human2.15927785
31THAP11_20581084_ChIP-Seq_MESCs_Mouse2.01774851
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.01243296
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91782133
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89170727
35ELK1_19687146_ChIP-ChIP_HELA_Human1.87933140
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.86006273
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.83752697
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.81829873
39MAF_26560356_Chip-Seq_TH2_Human1.81669138
40ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.77662879
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.73469404
42* LXR_22292898_ChIP-Seq_THP-1_Human1.72893499
43MAF_26560356_Chip-Seq_TH1_Human1.72828399
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69901671
45MYC_18940864_ChIP-ChIP_HL60_Human1.69115516
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.65320390
47MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.63172589
48CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.58749834
49* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.57841259
50SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.55947860
51KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.55666348
52GABP_19822575_ChIP-Seq_HepG2_Human1.55317276
53UTX_26944678_Chip-Seq_JUKART_Human1.54823823
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.54265957
55* BCL6_27268052_Chip-Seq_Bcells_Human1.53228669
56P68_20966046_ChIP-Seq_HELA_Human1.52166402
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.45565026
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.44759046
59CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.42744266
60STAT6_21828071_ChIP-Seq_BEAS2B_Human1.42573263
61* E2F1_21310950_ChIP-Seq_MCF-7_Human1.40333330
62KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.39091998
63ELF1_20517297_ChIP-Seq_JURKAT_Human1.36328157
64IRF8_22096565_ChIP-ChIP_GC-B_Human1.34715190
65BCOR_27268052_Chip-Seq_Bcells_Human1.34525286
66* TET1_21451524_ChIP-Seq_MESCs_Mouse1.34362117
67* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.33790374
68AR_21909140_ChIP-Seq_LNCAP_Human1.33251530
69ELK1_22589737_ChIP-Seq_MCF10A_Human1.30688761
70CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.29919774
71RUNX1_22412390_ChIP-Seq_EML_Mouse1.28906556
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28109678
73KDM2B_26808549_Chip-Seq_DND41_Human1.27798921
74NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.26877145
75ELK3_25401928_ChIP-Seq_HUVEC_Human1.26445770
76RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.25674583
77FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.25541100
78NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25417410
79* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.24585867
80CIITA_25753668_ChIP-Seq_RAJI_Human1.24551333
81POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24351922
82POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.23555725
83* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22412856
84* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.21816646
85PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21687120
86TP63_19390658_ChIP-ChIP_HaCaT_Human1.20415081
87* TCF7_22412390_ChIP-Seq_EML_Mouse1.20175192
88E2F1_20622854_ChIP-Seq_HELA_Human1.20098403
89SA1_27219007_Chip-Seq_ERYTHROID_Human1.18314953
90GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17607309
91RACK7_27058665_Chip-Seq_MCF-7_Human1.14181922
92YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13960588
93SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12296337
94* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.09813209
95IRF8_21731497_ChIP-ChIP_J774_Mouse1.09494517
96FOXP1_21924763_ChIP-Seq_HESCs_Human1.09163887
97CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08797078
98CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08781258
99PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08474066
100VDR_21846776_ChIP-Seq_THP-1_Human1.08126247
101CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07959027
102PHF8_20622854_ChIP-Seq_HELA_Human1.07119355
103MYB_26560356_Chip-Seq_TH1_Human1.07085103
104SCL_19346495_ChIP-Seq_HPC-7_Human1.06109166
105* CTCF_21964334_Chip-Seq_Bcells_Human1.05491801
106* CTCF_26484167_Chip-Seq_Bcells_Mouse1.04633475
107SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04223568
108SOX2_18555785_ChIP-Seq_MESCs_Mouse1.03136385
109SOX2_16153702_ChIP-ChIP_HESCs_Human1.00945269
110SPI1_23547873_ChIP-Seq_NB4_Human1.00159597
111IRF1_19129219_ChIP-ChIP_H3396_Human0.99809134
112ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99367271
113GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96755931
114E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96001483
115ZFX_18555785_ChIP-Seq_MESCs_Mouse0.90711605
116PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89368644
117CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88487122
118TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.88190212
119PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86298176
120STAT4_19710469_ChIP-ChIP_TH1__Mouse0.86254349
121KDM5A_27292631_Chip-Seq_BREAST_Human0.84802902
122NOTCH1_21737748_ChIP-Seq_TLL_Human0.81499829
123IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.80895406
124BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.78978607
125STAT1_20625510_ChIP-Seq_HELA_Human0.78239253
126BP1_19119308_ChIP-ChIP_Hs578T_Human0.76658276
127* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.74940703
128RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.71526336
129HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.71362968
130SOX17_20123909_ChIP-Seq_XEN_Mouse0.70934748
131* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68866750
132PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.66842066
133KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.65973306
134* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.63106013
135DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.62368425
136VDR_24763502_ChIP-Seq_THP-1_Human0.62334816
137YY1_22570637_ChIP-Seq_MALME-3M_Human0.61398288
138NANOG_16153702_ChIP-ChIP_HESCs_Human0.60224017
139MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.60055101

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.88049627
2MP0003693_abnormal_embryo_hatching3.92898989
3MP0003111_abnormal_nucleus_morphology3.14885507
4MP0010094_abnormal_chromosome_stability2.99808966
5MP0004957_abnormal_blastocyst_morpholog2.66888670
6MP0003303_peritoneal_inflammation2.62180019
7MP0003724_increased_susceptibility_to2.59901536
8MP0003077_abnormal_cell_cycle2.59787131
9MP0008260_abnormal_autophagy2.51233418
10MP0000685_abnormal_immune_system2.50401156
11MP0008057_abnormal_DNA_replication2.46895844
12MP0008932_abnormal_embryonic_tissue2.46591127
13MP0003806_abnormal_nucleotide_metabolis2.37060313
14MP0006292_abnormal_olfactory_placode2.30610741
15MP0003136_yellow_coat_color2.25946174
16MP0004381_abnormal_hair_follicle2.24490795
17MP0002419_abnormal_innate_immunity2.23908827
18MP0008058_abnormal_DNA_repair2.07521854
19MP0001529_abnormal_vocalization2.06013764
20MP0009278_abnormal_bone_marrow1.97585958
21MP0001188_hyperpigmentation1.97145434
22MP0003786_premature_aging1.89446660
23MP0005451_abnormal_body_composition1.89282237
24MP0003878_abnormal_ear_physiology1.88719162
25MP0005377_hearing/vestibular/ear_phenot1.88719162
26MP0005387_immune_system_phenotype1.84726744
27MP0001790_abnormal_immune_system1.84726744
28MP0000566_synostosis1.84504009
29MP0003315_abnormal_perineum_morphology1.82535306
30MP0002102_abnormal_ear_morphology1.81040668
31MP0008007_abnormal_cellular_replicative1.76427918
32MP0002132_abnormal_respiratory_system1.75847724
33MP0002277_abnormal_respiratory_mucosa1.72100608
34MP0005409_darkened_coat_color1.71174400
35MP0010030_abnormal_orbit_morphology1.68193546
36MP0005174_abnormal_tail_pigmentation1.62095655
37MP0000490_abnormal_crypts_of1.61798630
38MP0003656_abnormal_erythrocyte_physiolo1.59272372
39MP0000015_abnormal_ear_pigmentation1.53170278
40MP0009333_abnormal_splenocyte_physiolog1.52839112
41MP0002163_abnormal_gland_morphology1.52495870
42MP0000049_abnormal_middle_ear1.43862985
43MP0003880_abnormal_central_pattern1.43755476
44MP0002095_abnormal_skin_pigmentation1.41586591
45MP0006276_abnormal_autonomic_nervous1.40336116
46MP0002751_abnormal_autonomic_nervous1.39063228
47MP0008995_early_reproductive_senescence1.34858867
48MP0001533_abnormal_skeleton_physiology1.30758665
49MP0003191_abnormal_cellular_cholesterol1.29727808
50MP0005075_abnormal_melanosome_morpholog1.27815338
51MP0002638_abnormal_pupillary_reflex1.27500774
52MP0005410_abnormal_fertilization1.26265699
53MP0005076_abnormal_cell_differentiation1.26142401
54MP0003763_abnormal_thymus_physiology1.24373289
55MP0005671_abnormal_response_to1.21615665
56MP0009764_decreased_sensitivity_to1.21045942
57MP0001986_abnormal_taste_sensitivity1.21039842
58MP0008004_abnormal_stomach_pH1.19166359
59MP0003172_abnormal_lysosome_physiology1.18249854
60MP0003718_maternal_effect1.18079182
61MP0002148_abnormal_hypersensitivity_rea1.15848397
62MP0008469_abnormal_protein_level1.13334957
63MP0000703_abnormal_thymus_morphology1.12770504
64MP0003938_abnormal_ear_development1.12697332
65MP0001845_abnormal_inflammatory_respons1.12686632
66MP0004742_abnormal_vestibular_system1.09096681
67MP0008789_abnormal_olfactory_epithelium1.08070979
68MP0000350_abnormal_cell_proliferation1.06950634
69MP0002398_abnormal_bone_marrow1.05328613
70MP0005058_abnormal_lysosome_morphology1.05069699
71MP0003121_genomic_imprinting1.04555733
72MP0002938_white_spotting1.04360073
73MP0001905_abnormal_dopamine_level1.04185293
74MP0001873_stomach_inflammation1.02658220
75MP0006036_abnormal_mitochondrial_physio1.01677763
76MP0002396_abnormal_hematopoietic_system1.00810218
77MP0004808_abnormal_hematopoietic_stem1.00244142
78MP0004142_abnormal_muscle_tone0.99755136
79MP0005464_abnormal_platelet_physiology0.98902253
80MP0001853_heart_inflammation0.98711657
81MP0004947_skin_inflammation0.98072008
82MP0005423_abnormal_somatic_nervous0.98008758
83MP0001545_abnormal_hematopoietic_system0.96165309
84MP0005397_hematopoietic_system_phenotyp0.96165309
85MP0009785_altered_susceptibility_to0.95730914
86MP0010155_abnormal_intestine_physiology0.94676502
87MP0005000_abnormal_immune_tolerance0.94468501
88MP0002653_abnormal_ependyma_morphology0.91354903
89MP0000678_abnormal_parathyroid_gland0.91202030
90* MP0000313_abnormal_cell_death0.91081295
91MP0000372_irregular_coat_pigmentation0.91033433
92MP0002420_abnormal_adaptive_immunity0.89238665
93MP0005257_abnormal_intraocular_pressure0.87744235
94MP0001819_abnormal_immune_cell0.87376549
95MP0002210_abnormal_sex_determination0.87010514
96MP0002722_abnormal_immune_system0.86995148
97MP0001919_abnormal_reproductive_system0.86109146
98MP0005083_abnormal_biliary_tract0.86050752
99MP0002019_abnormal_tumor_incidence0.85904565
100MP0001929_abnormal_gametogenesis0.85205758
101MP0001727_abnormal_embryo_implantation0.84863508
102MP0001800_abnormal_humoral_immune0.83797676
103MP0002429_abnormal_blood_cell0.82350814
104MP0005501_abnormal_skin_physiology0.81312958
105MP0005025_abnormal_response_to0.80976391
106MP0009250_abnormal_appendicular_skeleto0.80685572
107MP0000026_abnormal_inner_ear0.80345561
108MP0005381_digestive/alimentary_phenotyp0.79240464
109MP0002249_abnormal_larynx_morphology0.79072385
110MP0001485_abnormal_pinna_reflex0.78997746
111MP0010307_abnormal_tumor_latency0.78994270
112MP0001346_abnormal_lacrimal_gland0.78878495
113MP0000716_abnormal_immune_system0.78858160
114MP0006035_abnormal_mitochondrial_morpho0.77954098
115MP0003123_paternal_imprinting0.77768017
116MP0002452_abnormal_antigen_presenting0.77616845
117MP0001663_abnormal_digestive_system0.76969141
118MP0004185_abnormal_adipocyte_glucose0.76920986
119MP0002177_abnormal_outer_ear0.76310411
120MP0000631_abnormal_neuroendocrine_gland0.75793966
121MP0002405_respiratory_system_inflammati0.75071962
122MP0005171_absent_coat_pigmentation0.74814582
123MP0003183_abnormal_peptide_metabolism0.74638013
124MP0003787_abnormal_imprinting0.74438688
125MP0003436_decreased_susceptibility_to0.74352074
126MP0002723_abnormal_immune_serum0.74171967
127MP0001286_abnormal_eye_development0.74101604
128MP0003937_abnormal_limbs/digits/tail_de0.73008976
129MP0000689_abnormal_spleen_morphology0.72729666
130MP0000465_gastrointestinal_hemorrhage0.72650556
131MP0001697_abnormal_embryo_size0.71523254
132MP0001835_abnormal_antigen_presentation0.70832013
133MP0008877_abnormal_DNA_methylation0.70795508
134MP0006082_CNS_inflammation0.70716858
135MP0000858_altered_metastatic_potential0.69707857
136MP0003385_abnormal_body_wall0.69609770
137MP0001730_embryonic_growth_arrest0.69518798
138MP0002736_abnormal_nociception_after0.68539580
139MP0005645_abnormal_hypothalamus_physiol0.67808416
140MP0000462_abnormal_digestive_system0.67559792
141MP0003866_abnormal_defecation0.67210047
142MP0002080_prenatal_lethality0.67081462
143MP0003300_gastrointestinal_ulcer0.66379958
144MP0003698_abnormal_male_reproductive0.65638413
145MP0008873_increased_physiological_sensi0.64826175

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.93451708
2Abnormality of cells of the erythroid lineage (HP:0012130)4.74041142
3Abnormal number of erythroid precursors (HP:0012131)4.61308437
4Recurrent abscess formation (HP:0002722)4.49959608
5Recurrent bacterial skin infections (HP:0005406)4.28976585
6Macrocytic anemia (HP:0001972)4.24919085
7Aplasia/Hypoplasia of the sacrum (HP:0008517)4.13848826
8Pallor (HP:0000980)3.94190946
9Eczematoid dermatitis (HP:0000976)3.93743760
10Increased hepatocellular lipid droplets (HP:0006565)3.83639022
11Mitochondrial inheritance (HP:0001427)3.70947764
12Hypochromic microcytic anemia (HP:0004840)3.67855270
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.62246614
14Hypochromic anemia (HP:0001931)3.58311355
15Acute necrotizing encephalopathy (HP:0006965)3.45348654
16Myositis (HP:0100614)3.42206333
17Exertional dyspnea (HP:0002875)3.36629605
18Hepatocellular necrosis (HP:0001404)3.34396973
19Renal Fanconi syndrome (HP:0001994)3.22131589
20Parakeratosis (HP:0001036)3.21691767
21Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.20505499
22Gastrointestinal infarctions (HP:0005244)3.19152060
23Recurrent fungal infections (HP:0002841)3.11268994
24Chromosomal breakage induced by crosslinking agents (HP:0003221)3.08147171
25Lipid accumulation in hepatocytes (HP:0006561)3.06488265
263-Methylglutaconic aciduria (HP:0003535)3.05308576
27Abnormality of macrophages (HP:0004311)3.04016180
28Triphalangeal thumb (HP:0001199)2.98874289
29Orchitis (HP:0100796)2.98194405
30Abnormal mitochondria in muscle tissue (HP:0008316)2.97552862
31Abnormal delayed hypersensitivity skin test (HP:0002963)2.97248612
32Chromsome breakage (HP:0040012)2.96847719
33Meningitis (HP:0001287)2.93724254
34Recurrent gram-negative bacterial infections (HP:0005420)2.92081810
35Abnormality of the preputium (HP:0100587)2.90309265
36Increased CSF lactate (HP:0002490)2.88507908
37Recurrent skin infections (HP:0001581)2.88215532
38Severe visual impairment (HP:0001141)2.84497086
39Breast hypoplasia (HP:0003187)2.83779691
40Elevated erythrocyte sedimentation rate (HP:0003565)2.81481302
41Mediastinal lymphadenopathy (HP:0100721)2.79456033
42Progressive macrocephaly (HP:0004481)2.78558065
43Panhypogammaglobulinemia (HP:0003139)2.75554207
44Abnormal hemoglobin (HP:0011902)2.74260404
45Recurrent cutaneous fungal infections (HP:0011370)2.74107289
46Chronic mucocutaneous candidiasis (HP:0002728)2.74107289
47Retrobulbar optic neuritis (HP:0100654)2.73694862
48Optic neuritis (HP:0100653)2.73694862
49Cellulitis (HP:0100658)2.66842032
50Meckel diverticulum (HP:0002245)2.65872385
51Encephalitis (HP:0002383)2.64761262
52Anorexia (HP:0002039)2.63984044
53Duplicated collecting system (HP:0000081)2.63750106
54Microcytic anemia (HP:0001935)2.61723445
55Patellar aplasia (HP:0006443)2.59301954
56Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.57454539
57Aplasia/Hypoplasia of the patella (HP:0006498)2.54217188
58Abnormality of the ileum (HP:0001549)2.49413187
59Hepatic necrosis (HP:0002605)2.48945551
60Absent thumb (HP:0009777)2.47417306
61Horseshoe kidney (HP:0000085)2.45586371
62Increased IgE level (HP:0003212)2.44084178
63Concave nail (HP:0001598)2.40367658
64Increased serum lactate (HP:0002151)2.38795543
65Acute encephalopathy (HP:0006846)2.37939246
66Squamous cell carcinoma (HP:0002860)2.37305582
67Aplasia/Hypoplasia of the uvula (HP:0010293)2.36303370
68Birth length less than 3rd percentile (HP:0003561)2.35808105
69Cerebral hypomyelination (HP:0006808)2.35487229
70Petechiae (HP:0000967)2.34468312
71Increased intramyocellular lipid droplets (HP:0012240)2.34392723
72Urticaria (HP:0001025)2.33815948
73Hepatosplenomegaly (HP:0001433)2.33765832
74Chronic obstructive pulmonary disease (HP:0006510)2.33678602
75Obstructive lung disease (HP:0006536)2.33678602
76Stomatitis (HP:0010280)2.30743214
77Abnormality of chromosome stability (HP:0003220)2.29863604
78Abnormality of the heme biosynthetic pathway (HP:0010472)2.29567623
79Oral leukoplakia (HP:0002745)2.29506414
80Absent radius (HP:0003974)2.27461953
81Abnormality of the renal collecting system (HP:0004742)2.27102360
82Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.26417714
83Decreased activity of mitochondrial respiratory chain (HP:0008972)2.22486391
84Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.22486391
85Abnormality of T cell physiology (HP:0011840)2.21774107
86Hypertensive crisis (HP:0100735)2.18644195
87Myelodysplasia (HP:0002863)2.17923556
88Trismus (HP:0000211)2.17742168
89Colitis (HP:0002583)2.16444055
90Respiratory difficulties (HP:0002880)2.16398612
91Broad distal phalanx of finger (HP:0009836)2.15797788
92Rough bone trabeculation (HP:0100670)2.13733401
93Aplasia involving forearm bones (HP:0009822)2.13717833
94Absent forearm bone (HP:0003953)2.13717833
95Gingivitis (HP:0000230)2.10753072
96Intestinal fistula (HP:0100819)2.09341301
97Keratoconjunctivitis sicca (HP:0001097)2.07461114
9811 pairs of ribs (HP:0000878)2.06767382
99Cleft eyelid (HP:0000625)2.06481448
100Amniotic constriction ring (HP:0009775)2.04274099
101Abnormality of placental membranes (HP:0011409)2.04274099
102Recurrent viral infections (HP:0004429)2.04135044
103Abnormality of dental color (HP:0011073)2.03447843
104Asplenia (HP:0001746)2.02895984
105Gastrointestinal inflammation (HP:0004386)2.02720040
106Seborrheic dermatitis (HP:0001051)2.02370490
107Optic disc pallor (HP:0000543)2.01595331
108Depressed nasal ridge (HP:0000457)2.01342149
109Exercise intolerance (HP:0003546)2.00088847
110Inflammation of the large intestine (HP:0002037)1.99911727
111Abnormality of renal resorption (HP:0011038)1.99479283
112Respiratory failure (HP:0002878)1.99462540
113Premature graying of hair (HP:0002216)1.94336137
114Aplasia/Hypoplasia of the thymus (HP:0010515)1.94252880
115IgM deficiency (HP:0002850)1.94243815
116Duodenal stenosis (HP:0100867)1.92489732
117Small intestinal stenosis (HP:0012848)1.92489732
118Nasal polyposis (HP:0100582)1.90239700
119Type I transferrin isoform profile (HP:0003642)1.89272467
120Abnormality of reticulocytes (HP:0004312)1.88972579
121Severe combined immunodeficiency (HP:0004430)1.84613962
122Hypoplasia of the radius (HP:0002984)1.84596291
123Congenital, generalized hypertrichosis (HP:0004540)1.84022487
124Prolonged bleeding time (HP:0003010)1.83426392
125Impulsivity (HP:0100710)1.82628370
126Abnormality of the pleura (HP:0002103)1.82371007
127Bone marrow hypocellularity (HP:0005528)1.82216798
128Duplication of thumb phalanx (HP:0009942)1.82104656
129Rectovaginal fistula (HP:0000143)1.80794048
130Rectal fistula (HP:0100590)1.80794048
131Agammaglobulinemia (HP:0004432)1.80512003
132Keratoconjunctivitis (HP:0001096)1.80419833
133Vasculitis (HP:0002633)1.80000604
134Aplasia/Hypoplasia of the spleen (HP:0010451)1.79291676
135Abnormal number of incisors (HP:0011064)1.78861429
136Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.78347934
137Tracheoesophageal fistula (HP:0002575)1.78176045
138Pancytopenia (HP:0001876)1.76966806
139Thick lower lip vermilion (HP:0000179)1.76314944
140Abnormal trabecular bone morphology (HP:0100671)1.76078020
141Increased muscle lipid content (HP:0009058)1.75962883
142Abnormal lung lobation (HP:0002101)1.75030384
143Progressive muscle weakness (HP:0003323)1.74990014
144Increased serum ferritin (HP:0003281)1.74728429
145Abnormality of the septum pellucidum (HP:0007375)1.73709817
146Hypoplasia of the capital femoral epiphysis (HP:0003090)1.73311485
147Secondary amenorrhea (HP:0000869)1.72811582
148Anencephaly (HP:0002323)1.72526401
149Microretrognathia (HP:0000308)1.71516925
150Leukodystrophy (HP:0002415)1.70489407
151Aplasia/Hypoplasia of the earlobes (HP:0009906)1.70270837
152Ectopic kidney (HP:0000086)1.69873001
153Septo-optic dysplasia (HP:0100842)1.69681830
154Aplastic anemia (HP:0001915)1.67820107
155Hypopigmented skin patches (HP:0001053)1.67732220
156Cutaneous photosensitivity (HP:0000992)1.67586171
157Absent rod-and cone-mediated responses on ERG (HP:0007688)1.63988353
158Aplasia/hypoplasia of the uterus (HP:0008684)1.62888875

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK16.89600258
2BUB14.53195880
3EIF2AK13.61383386
4NME23.09754179
5VRK23.03797276
6STK162.97058590
7MAP2K32.90987039
8RIPK42.64014775
9WEE12.45628342
10SRPK12.37481306
11VRK12.36677462
12ERN12.34704494
13SMG12.30735846
14CDC72.26430537
15PBK2.22735721
16CASK1.97811230
17TESK21.96594953
18TRIB31.95171660
19NME11.81297570
20MKNK21.74454136
21CLK11.70116061
22MKNK11.63927455
23TAF11.55882366
24IRAK41.50168583
25TNK21.48717316
26NEK21.46909467
27BLK1.46377698
28TYK21.43467354
29PLK11.41311688
30TAOK11.41068921
31UHMK11.36808349
32STK41.32496834
33CDK191.30049643
34MAP3K91.28008556
35MST41.24081540
36DYRK31.24004173
37AURKB1.21115820
38AURKA1.20978735
39CSK1.18640376
40ZAK1.17445122
41TTK1.14814340
42SIK11.14491425
43CDK81.13810593
44MAP3K111.10829068
45PLK41.10405138
46MAP3K31.08337730
47CCNB11.07727728
48MARK31.05337134
49TAOK21.04609968
50CDK71.01578759
51BRSK21.01366009
52YES11.00915936
53TBK10.98509793
54DYRK20.94582587
55RPS6KA50.94093040
56PIM20.93555222
57STK390.93257421
58TXK0.92765230
59EIF2AK20.90403952
60ACVR1B0.89548327
61IKBKE0.87669929
62CHEK20.86193531
63EIF2AK30.85816752
64MAP3K130.85732752
65BRAF0.83562648
66BRSK10.82472477
67BRD40.81984596
68IKBKB0.80567790
69IRAK20.80339012
70MAP3K120.79687078
71MAP4K10.78384538
72SIK20.77731269
73HCK0.77383364
74PRKD20.76792674
75LIMK10.76181723
76PLK30.73387226
77KDR0.71937148
78NEK90.71720121
79MAP3K140.69696691
80RPS6KC10.65125942
81RPS6KL10.65125942
82ADRBK20.64184446
83ATR0.64110780
84SIK30.64024499
85EPHB20.63519906
86IRAK10.63277357
87BCR0.62997508
88PASK0.62846452
89RPS6KA40.61879146
90CSNK2A10.60314591
91TEC0.60244455
92RPS6KA60.58751683
93MAP3K100.58399567
94PRPF4B0.58198222
95CSNK1G30.56379041
96PAK10.56113333
97MATK0.55427275
98BMPR1B0.54407812
99IRAK30.54207848
100KIT0.53642338
101MAP3K10.53355142
102MAPK130.52576845
103LYN0.52520365
104LRRK20.51306968
105FGR0.51174662
106TNIK0.50544435
107PTK60.50509875
108CDK120.49261339
109PDPK10.49154304
110MAP3K80.49075331
111MAPKAPK20.48450819
112NEK10.47487677
113JAK30.46903878
114KSR20.46644499
115DAPK30.46460057
116STK100.46362669
117CSNK2A20.46257854
118PKN10.46079995
119FES0.44592949
120PIK3CG0.43113035
121CDK90.42223798
122TESK10.41923723
123SYK0.41862503
124CDK11A0.41625962
125CDK140.41586126
126BTK0.41121693
127ARAF0.40788792
128PIM10.40383822
129CHEK10.39739223
130CSNK1G10.38754383
131ZAP700.38599874
132GRK60.38174887
133MAPK150.37757885
134MAPK110.37301997
135CDK40.37217161
136OXSR10.36417120
137LCK0.35570885
138MAP2K20.35510570
139RPS6KB20.35178892
140CDK180.34957026
141PRKCI0.34791871
142RPS6KA10.34372938
143CDK20.34140233
144MAPKAPK50.34048399
145CDC42BPA0.33963455
146CDK150.33763879
147MELK0.33443432

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.42278613
2DNA replication_Homo sapiens_hsa030304.07207265
3RNA polymerase_Homo sapiens_hsa030203.32043564
4Mismatch repair_Homo sapiens_hsa034303.31748824
5Proteasome_Homo sapiens_hsa030503.11645704
6Homologous recombination_Homo sapiens_hsa034403.04878192
7Spliceosome_Homo sapiens_hsa030402.79186306
8Oxidative phosphorylation_Homo sapiens_hsa001902.71158143
9Base excision repair_Homo sapiens_hsa034102.57361969
10Nucleotide excision repair_Homo sapiens_hsa034202.43742223
11Parkinsons disease_Homo sapiens_hsa050122.42038152
12Fanconi anemia pathway_Homo sapiens_hsa034602.36986164
13Pyrimidine metabolism_Homo sapiens_hsa002402.30159333
14Protein export_Homo sapiens_hsa030602.15825541
15Huntingtons disease_Homo sapiens_hsa050161.98576290
16Cell cycle_Homo sapiens_hsa041101.93589540
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.93239673
18Systemic lupus erythematosus_Homo sapiens_hsa053221.87334822
19Basal transcription factors_Homo sapiens_hsa030221.84323099
20Alzheimers disease_Homo sapiens_hsa050101.69570615
21Osteoclast differentiation_Homo sapiens_hsa043801.63582185
22RNA transport_Homo sapiens_hsa030131.61662596
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.54388984
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.48941155
25B cell receptor signaling pathway_Homo sapiens_hsa046621.46153601
26Non-homologous end-joining_Homo sapiens_hsa034501.46105470
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.31575607
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.26343346
29Sulfur relay system_Homo sapiens_hsa041221.26116430
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.25261649
31One carbon pool by folate_Homo sapiens_hsa006701.25131202
32Acute myeloid leukemia_Homo sapiens_hsa052211.21587667
33Staphylococcus aureus infection_Homo sapiens_hsa051501.20952743
34Primary immunodeficiency_Homo sapiens_hsa053401.19038218
35Purine metabolism_Homo sapiens_hsa002301.16981265
36RNA degradation_Homo sapiens_hsa030181.13322735
37Tuberculosis_Homo sapiens_hsa051521.10634345
38p53 signaling pathway_Homo sapiens_hsa041151.06995932
39Alcoholism_Homo sapiens_hsa050341.01594581
40mRNA surveillance pathway_Homo sapiens_hsa030150.99717833
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.99114886
42Epstein-Barr virus infection_Homo sapiens_hsa051690.97901571
43Influenza A_Homo sapiens_hsa051640.97635915
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91938698
45Non-small cell lung cancer_Homo sapiens_hsa052230.89483147
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89234110
47Intestinal immune network for IgA production_Homo sapiens_hsa046720.76239856
48Viral myocarditis_Homo sapiens_hsa054160.75506338
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75425665
50Herpes simplex infection_Homo sapiens_hsa051680.75297373
51Graft-versus-host disease_Homo sapiens_hsa053320.73292085
52Toxoplasmosis_Homo sapiens_hsa051450.72208188
53Type I diabetes mellitus_Homo sapiens_hsa049400.70162316
54Pancreatic cancer_Homo sapiens_hsa052120.69489976
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69378589
56Chemokine signaling pathway_Homo sapiens_hsa040620.68887984
57Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68634697
58Arachidonic acid metabolism_Homo sapiens_hsa005900.67989724
59Hematopoietic cell lineage_Homo sapiens_hsa046400.67685177
60Allograft rejection_Homo sapiens_hsa053300.67531356
61Cardiac muscle contraction_Homo sapiens_hsa042600.66914192
62Chronic myeloid leukemia_Homo sapiens_hsa052200.65963309
63African trypanosomiasis_Homo sapiens_hsa051430.63012711
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62352750
65Legionellosis_Homo sapiens_hsa051340.60778174
66Viral carcinogenesis_Homo sapiens_hsa052030.57897588
67Ether lipid metabolism_Homo sapiens_hsa005650.57538105
68Hepatitis C_Homo sapiens_hsa051600.56294258
69Folate biosynthesis_Homo sapiens_hsa007900.56011568
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52320846
71Oocyte meiosis_Homo sapiens_hsa041140.51920993
72Collecting duct acid secretion_Homo sapiens_hsa049660.51652381
73Asthma_Homo sapiens_hsa053100.51196216
74Autoimmune thyroid disease_Homo sapiens_hsa053200.49968142
75Sphingolipid metabolism_Homo sapiens_hsa006000.49433269
76Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.49412825
77Steroid biosynthesis_Homo sapiens_hsa001000.47702608
78HTLV-I infection_Homo sapiens_hsa051660.45974622
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45374179
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44355350
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43717464
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.43507525
83Antigen processing and presentation_Homo sapiens_hsa046120.42015066
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41864080
85Regulation of autophagy_Homo sapiens_hsa041400.41783064
86VEGF signaling pathway_Homo sapiens_hsa043700.41674640
87Vitamin digestion and absorption_Homo sapiens_hsa049770.41038858
88Measles_Homo sapiens_hsa051620.40945974
89Shigellosis_Homo sapiens_hsa051310.39344308
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38677434
91TNF signaling pathway_Homo sapiens_hsa046680.37859975
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36959935
93Glutathione metabolism_Homo sapiens_hsa004800.35919147
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35709142
95Basal cell carcinoma_Homo sapiens_hsa052170.34886487
96Malaria_Homo sapiens_hsa051440.34357456
97Other glycan degradation_Homo sapiens_hsa005110.34329495
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34120682
99Fructose and mannose metabolism_Homo sapiens_hsa000510.33437557
100Notch signaling pathway_Homo sapiens_hsa043300.33422621
101Linoleic acid metabolism_Homo sapiens_hsa005910.30614070
102Metabolic pathways_Homo sapiens_hsa011000.30586799
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30317689
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.30222161
105Apoptosis_Homo sapiens_hsa042100.29985136
106Renal cell carcinoma_Homo sapiens_hsa052110.29963152
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29063308
108Endocytosis_Homo sapiens_hsa041440.29001080
109T cell receptor signaling pathway_Homo sapiens_hsa046600.28180972
110Bladder cancer_Homo sapiens_hsa052190.26879175
111MicroRNAs in cancer_Homo sapiens_hsa052060.24743352
112Phototransduction_Homo sapiens_hsa047440.24658538
113Leishmaniasis_Homo sapiens_hsa051400.23321070
114Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.22981643
115Hepatitis B_Homo sapiens_hsa051610.22810567
116Phagosome_Homo sapiens_hsa041450.22446827
117Wnt signaling pathway_Homo sapiens_hsa043100.21508427
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.21447483
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.20875195
120Rheumatoid arthritis_Homo sapiens_hsa053230.19573650
121Vibrio cholerae infection_Homo sapiens_hsa051100.18478975
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.18252259
123RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.16891940
124Vitamin B6 metabolism_Homo sapiens_hsa007500.16758733
125Hedgehog signaling pathway_Homo sapiens_hsa043400.16367800
126Axon guidance_Homo sapiens_hsa043600.16321770
127Salmonella infection_Homo sapiens_hsa051320.15309430
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.14041798
129Pathways in cancer_Homo sapiens_hsa052000.14036552
130N-Glycan biosynthesis_Homo sapiens_hsa005100.13513086
131NOD-like receptor signaling pathway_Homo sapiens_hsa046210.13504025
132Jak-STAT signaling pathway_Homo sapiens_hsa046300.12997361
133Pertussis_Homo sapiens_hsa051330.12714258

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