MVK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the peroxisomal enzyme mevalonate kinase. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. Mevalonate kinase deficiency caused by mutation of this gene results in mevalonic aciduria, a disease characterized psychomotor retardation, failure to thrive, hepatosplenomegaly, anemia and recurrent febrile crises. Defects in this gene also cause hyperimmunoglobulinaemia D and periodic fever syndrome, a disorder characterized by recurrent episodes of fever associated with lymphadenopathy, arthralgia, gastrointestinal dismay and skin rash. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)8.51327210
2* cholesterol biosynthetic process (GO:0006695)8.21568124
3central nervous system myelination (GO:0022010)7.35281271
4axon ensheathment in central nervous system (GO:0032291)7.35281271
5* sterol biosynthetic process (GO:0016126)7.21619763
6negative regulation of organelle assembly (GO:1902116)7.08712250
7long-chain fatty acid biosynthetic process (GO:0042759)5.63075181
8* isoprenoid biosynthetic process (GO:0008299)5.50840106
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.47062189
10response to pheromone (GO:0019236)5.23129308
11axonemal dynein complex assembly (GO:0070286)5.20046110
12cell migration in hindbrain (GO:0021535)5.09876874
13arginine catabolic process (GO:0006527)5.00646977
14long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.95814734
15ensheathment of neurons (GO:0007272)4.81398495
16axon ensheathment (GO:0008366)4.81398495
17myelination (GO:0042552)4.80338081
18body morphogenesis (GO:0010171)4.66853966
19negative regulation of catenin import into nucleus (GO:0035414)4.62588102
20substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.58927687
21substrate-independent telencephalic tangential migration (GO:0021826)4.58927687
22behavioral response to nicotine (GO:0035095)4.50521361
23fatty-acyl-CoA biosynthetic process (GO:0046949)4.47766127
24long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.46421738
25establishment of mitochondrion localization (GO:0051654)4.16098539
26fatty-acyl-CoA metabolic process (GO:0035337)4.04691471
27L-phenylalanine catabolic process (GO:0006559)3.98831286
28erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.98831286
29regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.97950016
30embryonic body morphogenesis (GO:0010172)3.97176465
31ATP synthesis coupled proton transport (GO:0015986)3.92894573
32energy coupled proton transport, down electrochemical gradient (GO:0015985)3.92894573
33nonmotile primary cilium assembly (GO:0035058)3.91209700
34mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.86494247
35L-phenylalanine metabolic process (GO:0006558)3.81028745
36erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.81028745
37very long-chain fatty acid metabolic process (GO:0000038)3.79463125
38regulation of collateral sprouting (GO:0048670)3.76961339
39L-serine metabolic process (GO:0006563)3.75459124
40sulfur amino acid catabolic process (GO:0000098)3.70636294
41limb bud formation (GO:0060174)3.69441152
42substantia nigra development (GO:0021762)3.64855780
43thioester biosynthetic process (GO:0035384)3.64392940
44acyl-CoA biosynthetic process (GO:0071616)3.64392940
45homocysteine metabolic process (GO:0050667)3.59180177
46pyrimidine nucleobase catabolic process (GO:0006208)3.54954389
47regulation of plasminogen activation (GO:0010755)3.53184670
48neuron fate specification (GO:0048665)3.51041386
49* cholesterol metabolic process (GO:0008203)3.49948280
50microtubule severing (GO:0051013)3.49687932
51protein neddylation (GO:0045116)3.47790646
52response to methylmercury (GO:0051597)3.44988413
53negative regulation of axon extension involved in axon guidance (GO:0048843)3.43831055
54establishment of protein localization to mitochondrial membrane (GO:0090151)3.43071410
55arginine metabolic process (GO:0006525)3.40948701
56response to lipoprotein particle (GO:0055094)3.38770458
57regulation of respiratory system process (GO:0044065)3.38622068
58epithelial cilium movement (GO:0003351)3.34080305
59detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.28755679
60detection of temperature stimulus involved in sensory perception (GO:0050961)3.28755679
61positive regulation of actin filament depolymerization (GO:0030836)3.24255926
62* sterol metabolic process (GO:0016125)3.22130294
63glycerophospholipid catabolic process (GO:0046475)3.21741619
64* steroid biosynthetic process (GO:0006694)3.21570193
65microtubule bundle formation (GO:0001578)3.18206958
66negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.17783042
67cysteine metabolic process (GO:0006534)3.16476553
68negative regulation of microtubule polymerization (GO:0031115)3.15250228
69regulation of autophagic vacuole assembly (GO:2000785)3.13227077
70* alcohol biosynthetic process (GO:0046165)3.10714312
71motile cilium assembly (GO:0044458)3.07537918
72aldehyde catabolic process (GO:0046185)3.06910051
73negative regulation of axon guidance (GO:1902668)3.06077278
74ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.05289310
75regulation of ruffle assembly (GO:1900027)3.04393490
76axon extension (GO:0048675)3.03074191
77neuron recognition (GO:0008038)3.01537026
78amyloid precursor protein metabolic process (GO:0042982)3.01011244
79ethanol oxidation (GO:0006069)3.00951006
80positive regulation of mitochondrial fission (GO:0090141)2.98029576
81positive regulation of oligodendrocyte differentiation (GO:0048714)2.97284424
82mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.97251299
83protein polyglutamylation (GO:0018095)2.97219451
84astrocyte development (GO:0014002)2.96992932
85regulation of cilium movement (GO:0003352)2.96416615
86negative regulation of axon extension (GO:0030517)2.96037555
87regulation of microtubule-based movement (GO:0060632)2.93801478
88oligodendrocyte differentiation (GO:0048709)2.93712163
89heme transport (GO:0015886)2.92553746
90bone trabecula formation (GO:0060346)2.92499003
91somite development (GO:0061053)2.89633251
92detection of light stimulus involved in sensory perception (GO:0050962)2.88113609
93detection of light stimulus involved in visual perception (GO:0050908)2.88113609
94creatine metabolic process (GO:0006600)2.87970072
95segment specification (GO:0007379)2.87330989
96skeletal muscle organ development (GO:0060538)2.86232953
97axon development (GO:0061564)2.85535771
98positive regulation of cellular amine metabolic process (GO:0033240)2.81963548
99response to misfolded protein (GO:0051788)2.80937641
100* thioester metabolic process (GO:0035383)2.80487848
101* acyl-CoA metabolic process (GO:0006637)2.80487848
102negative regulation of DNA-templated transcription, elongation (GO:0032785)2.79702368
103myelin maintenance (GO:0043217)2.79683021
104postsynaptic membrane organization (GO:0001941)2.79579856
105white fat cell differentiation (GO:0050872)2.79459864
106cilium movement (GO:0003341)2.78565213
107neuron cell-cell adhesion (GO:0007158)2.77146010
108neural nucleus development (GO:0048857)2.75646926
109negative regulation of axonogenesis (GO:0050771)2.71276276
110glyoxylate metabolic process (GO:0046487)2.71209381
111peripheral nervous system neuron development (GO:0048935)2.71111402
112ethanol metabolic process (GO:0006067)2.70292046
113adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.70130335
114response to redox state (GO:0051775)2.68958960
115mitochondrial fusion (GO:0008053)2.68543901
116myelination in peripheral nervous system (GO:0022011)2.68153954
117peripheral nervous system axon ensheathment (GO:0032292)2.68153954
118detection of temperature stimulus (GO:0016048)2.67806408
119response to parathyroid hormone (GO:0071107)2.66925417
120neurofilament cytoskeleton organization (GO:0060052)2.66456600
121neuron projection extension (GO:1990138)2.63872140
122protein complex biogenesis (GO:0070271)2.63374488
123cellular biogenic amine catabolic process (GO:0042402)2.63240149
124amine catabolic process (GO:0009310)2.63240149
125tyrosine metabolic process (GO:0006570)2.62939915
126cellular response to cholesterol (GO:0071397)2.62426684
127neuronal ion channel clustering (GO:0045161)2.61937474
128citrulline metabolic process (GO:0000052)2.60404758
129translational elongation (GO:0006414)2.60387846
130serine family amino acid biosynthetic process (GO:0009070)2.58806204
131nucleobase catabolic process (GO:0046113)2.58735311
132axonal fasciculation (GO:0007413)2.57974487
133terpenoid biosynthetic process (GO:0016114)2.57437597
134coenzyme catabolic process (GO:0009109)2.57408246
135RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.57328262
136tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.57328262
137calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.56729985
138cell proliferation in forebrain (GO:0021846)2.56710264
139iron coordination entity transport (GO:1901678)2.55500957
140amyloid precursor protein catabolic process (GO:0042987)2.55431882
141cerebral cortex radially oriented cell migration (GO:0021799)2.55393018
142positive regulation of protein depolymerization (GO:1901881)2.54334067
143* acetyl-CoA metabolic process (GO:0006084)2.52752840
144regulation of vacuole organization (GO:0044088)2.51876923
145peptidyl-cysteine modification (GO:0018198)2.51486547
146receptor recycling (GO:0001881)2.49772790
147cellular copper ion homeostasis (GO:0006878)2.49030158
148respiratory electron transport chain (GO:0022904)2.48330243
149positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.47460674
150apical protein localization (GO:0045176)2.47043657
151head development (GO:0060322)2.46958361
152dendritic spine morphogenesis (GO:0060997)2.46688153
153cellular protein complex disassembly (GO:0043624)2.46355674
154spinal cord development (GO:0021510)2.46210132
155viral transcription (GO:0019083)2.45639121
156mitochondrion transport along microtubule (GO:0047497)2.44990072
157establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.44990072
158negative regulation of protein localization to cell surface (GO:2000009)2.44951149
159synaptic transmission, cholinergic (GO:0007271)2.44802089
160electron transport chain (GO:0022900)2.44734469
161aromatic amino acid family catabolic process (GO:0009074)2.44581921
162metallo-sulfur cluster assembly (GO:0031163)2.44225620
163iron-sulfur cluster assembly (GO:0016226)2.44225620
164protein targeting to ER (GO:0045047)2.42984105
165regulation of cilium assembly (GO:1902017)2.42680281
166establishment of mitotic spindle orientation (GO:0000132)2.42256059
167viral life cycle (GO:0019058)2.41596290
168cotranslational protein targeting to membrane (GO:0006613)2.39757923
169positive regulation of pseudopodium assembly (GO:0031274)2.39675146
170translational termination (GO:0006415)2.39594780
171chaperone-mediated protein transport (GO:0072321)2.39277094
172regulation of lipoprotein metabolic process (GO:0050746)2.38502953
173SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.37455720
174indolalkylamine metabolic process (GO:0006586)2.36699626
175glandular epithelial cell differentiation (GO:0002067)2.36480639
176serine family amino acid catabolic process (GO:0009071)2.35625137

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.40331386
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.25353079
3PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.14153126
4CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.01888346
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.61839322
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.38876541
7AR_21572438_ChIP-Seq_LNCaP_Human2.36669970
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.36471423
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.30858768
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.22345802
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.20053211
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.18891407
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.12115467
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.08647409
15* PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.02508947
16EZH2_27294783_Chip-Seq_ESCs_Mouse1.98941778
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.98833887
18REST_21632747_ChIP-Seq_MESCs_Mouse1.92561743
19JARID2_20064375_ChIP-Seq_MESCs_Mouse1.91350003
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.91345737
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.90966131
22PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.88856519
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.86930434
24RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.86690581
25REST_18959480_ChIP-ChIP_MESCs_Mouse1.85484167
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.84068545
27CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.81259748
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.76659528
29EZH2_18974828_ChIP-Seq_MESCs_Mouse1.75058632
30RNF2_18974828_ChIP-Seq_MESCs_Mouse1.75058632
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.74957002
32P68_20966046_ChIP-Seq_HELA_Human1.74377263
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.74059890
34XRN2_22483619_ChIP-Seq_HELA_Human1.68778787
35WT1_19549856_ChIP-ChIP_CCG9911_Human1.68069142
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.66165519
37RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.65699900
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.63959669
39IRF1_19129219_ChIP-ChIP_H3396_Human1.62682966
40TET1_21451524_ChIP-Seq_MESCs_Mouse1.61897886
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57759761
42* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.57134473
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.57083957
44SRY_22984422_ChIP-ChIP_TESTIS_Rat1.56863155
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.55887577
46CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.54656980
47MTF2_20144788_ChIP-Seq_MESCs_Mouse1.54151586
48LXR_22292898_ChIP-Seq_THP-1_Human1.50490073
49RARG_19884340_ChIP-ChIP_MEFs_Mouse1.46225520
50EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44432036
51KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.43717012
52YY1_22570637_ChIP-Seq_MALME-3M_Human1.43399379
53SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.42906342
54EZH2_22144423_ChIP-Seq_EOC_Human1.42741928
55SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.42727289
56MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.41030101
57* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.40516259
58PHF8_20622854_ChIP-Seq_HELA_Human1.38860956
59TP53_20018659_ChIP-ChIP_R1E_Mouse1.37691522
60OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.36434141
61KDM2B_26808549_Chip-Seq_K562_Human1.35289840
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35074377
63TP53_22127205_ChIP-Seq_IMR90_Human1.33988253
64ERG_21242973_ChIP-ChIP_JURKAT_Human1.33946417
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.33832851
66E2F1_20622854_ChIP-Seq_HELA_Human1.33124304
67SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.31359720
68RXR_22158963_ChIP-Seq_LIVER_Mouse1.26872265
69NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.25148246
70CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.24670743
71CTCF_20526341_ChIP-Seq_ESCs_Human1.24143397
72THAP11_20581084_ChIP-Seq_MESCs_Mouse1.22996375
73EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.22421768
74RNF2_27304074_Chip-Seq_ESCs_Mouse1.21670205
75PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.21286166
76ZNF263_19887448_ChIP-Seq_K562_Human1.20028931
77ETV2_25802403_ChIP-Seq_MESCs_Mouse1.19711396
78ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19624536
79* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.19118028
80FOXP1_21924763_ChIP-Seq_HESCs_Human1.17461897
81RNF2_27304074_Chip-Seq_NSC_Mouse1.16915193
82SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16641276
83CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.16508856
84HTT_18923047_ChIP-ChIP_STHdh_Human1.16481919
85EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14883847
86HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.14150172
87GBX2_23144817_ChIP-Seq_PC3_Human1.13316899
88BCL6_27268052_Chip-Seq_Bcells_Human1.12622072
89BCOR_27268052_Chip-Seq_Bcells_Human1.11943081
90CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.11691036
91* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10124841
92ETS1_20019798_ChIP-Seq_JURKAT_Human1.09997724
93TAF2_19829295_ChIP-Seq_ESCs_Human1.09929855
94* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09845663
95GABP_19822575_ChIP-Seq_HepG2_Human1.09732207
96ELF1_20517297_ChIP-Seq_JURKAT_Human1.09211787
97PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08264836
98RING1B_27294783_Chip-Seq_NPCs_Mouse1.08238356
99P63_26484246_Chip-Seq_KERATINOCYTES_Human1.07736730
100ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07263682
101UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03464026
102SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.03192137
103PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.02607282
104CTCF_27219007_Chip-Seq_Bcells_Human1.01611336
105GATA1_26923725_Chip-Seq_HPCs_Mouse1.01289109
106SMC4_20622854_ChIP-Seq_HELA_Human1.00762955
107CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98369833
108ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.98241618
109CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98169859
110FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.96215700
111OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95851316
112* RARA_24833708_ChIP-Seq_LIVER_Mouse0.94823997
113DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94413303
114SMC3_22415368_ChIP-Seq_MEFs_Mouse0.94281006
115* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93866138
116STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.93782783
117RING1B_27294783_Chip-Seq_ESCs_Mouse0.93675170
118CTCF_18555785_ChIP-Seq_MESCs_Mouse0.93432210
119OCT4_19829295_ChIP-Seq_ESCs_Human0.93020334
120GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92737772
121NANOG_20526341_ChIP-Seq_ESCs_Human0.92449929
122ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.92022985
123MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.91630991
124CREB1_26743006_Chip-Seq_LNCaP_Human0.90965045
125KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.90893801
126NCOR_22424771_ChIP-Seq_293T_Human0.90375061
127RARB_27405468_Chip-Seq_BRAIN_Mouse0.90134897
128SOX2_16153702_ChIP-ChIP_HESCs_Human0.89597910
129HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.89037954
130STAT6_21828071_ChIP-Seq_BEAS2B_Human0.88902654
131* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.88487375
132SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87733516
133CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.86943336
134VDR_22108803_ChIP-Seq_LS180_Human0.86730285
135SOX2_22085726_ChIP-Seq_NPCs_Mouse0.86462298
136KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.85190128
137CTBP1_25329375_ChIP-Seq_LNCAP_Human0.85069806
138TAF15_26573619_Chip-Seq_HEK293_Human0.83601563
139SOX2_18692474_ChIP-Seq_MEFs_Mouse0.83501458
140NR3C1_23031785_ChIP-Seq_PC12_Mouse0.83084640
141CLOCK_20551151_ChIP-Seq_293T_Human0.82296922
142CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.81283405
143SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.81143928
144EOMES_21245162_ChIP-Seq_HESCs_Human0.80811653
145SOX17_20123909_ChIP-Seq_XEN_Mouse0.80477469
146SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.80104190
147CREB1_15753290_ChIP-ChIP_HEK293T_Human0.79299807
148PPARA_22158963_ChIP-Seq_LIVER_Mouse0.78144251
149TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77543054
150EGR1_23403033_ChIP-Seq_LIVER_Mouse0.77279264
151ZFP281_18757296_ChIP-ChIP_E14_Mouse0.77012214
152RAD21_21589869_ChIP-Seq_MESCs_Mouse0.76974968
153SMC1_22415368_ChIP-Seq_MEFs_Mouse0.75266223
154SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.72296388
155P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.71386555
156TCF3_18692474_ChIP-Seq_MEFs_Mouse0.70743327

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.75354284
2MP0000920_abnormal_myelination3.35403612
3MP0003123_paternal_imprinting3.26939626
4MP0003122_maternal_imprinting3.20907389
5MP0006292_abnormal_olfactory_placode2.99909542
6MP0001529_abnormal_vocalization2.89680231
7MP0005394_taste/olfaction_phenotype2.87617420
8MP0005499_abnormal_olfactory_system2.87617420
9MP0002139_abnormal_hepatobiliary_system2.61136307
10MP0003787_abnormal_imprinting2.54909659
11MP0000778_abnormal_nervous_system2.39396301
12MP0003329_amyloid_beta_deposits2.36342267
13MP0009379_abnormal_foot_pigmentation2.29729694
14MP0004270_analgesia2.24574380
15MP0009840_abnormal_foam_cell2.22249051
16MP0003121_genomic_imprinting2.20790930
17MP0004142_abnormal_muscle_tone2.10053461
18MP0005083_abnormal_biliary_tract2.09105101
19MP0002796_impaired_skin_barrier2.04358095
20MP0008438_abnormal_cutaneous_collagen2.02055704
21MP0000049_abnormal_middle_ear2.01566052
22MP0002653_abnormal_ependyma_morphology2.00887615
23MP0005360_urolithiasis2.00812274
24MP0005645_abnormal_hypothalamus_physiol1.97453354
25MP0008004_abnormal_stomach_pH1.96117781
26MP0003950_abnormal_plasma_membrane1.94649244
27MP0006276_abnormal_autonomic_nervous1.89519351
28MP0004742_abnormal_vestibular_system1.87384203
29MP0005451_abnormal_body_composition1.87001647
30MP0005646_abnormal_pituitary_gland1.85291812
31MP0002837_dystrophic_cardiac_calcinosis1.84741093
32MP0002822_catalepsy1.84723945
33MP0003634_abnormal_glial_cell1.84185724
34MP0001905_abnormal_dopamine_level1.84136981
35MP0003011_delayed_dark_adaptation1.81165121
36MP0010030_abnormal_orbit_morphology1.79144362
37MP0004133_heterotaxia1.76739823
38MP0000647_abnormal_sebaceous_gland1.76131363
39MP0000462_abnormal_digestive_system1.71968030
40MP0008995_early_reproductive_senescence1.67440035
41MP0004381_abnormal_hair_follicle1.64790656
42MP0002751_abnormal_autonomic_nervous1.63625718
43MP0000566_synostosis1.62608868
44MP0001293_anophthalmia1.60820449
45MP0003879_abnormal_hair_cell1.60546203
46MP0003136_yellow_coat_color1.59509526
47MP0005423_abnormal_somatic_nervous1.58594820
48MP0003878_abnormal_ear_physiology1.57120222
49MP0005377_hearing/vestibular/ear_phenot1.57120222
50MP0005171_absent_coat_pigmentation1.55614386
51MP0002734_abnormal_mechanical_nocicepti1.54220758
52MP0005623_abnormal_meninges_morphology1.50509647
53MP0003632_abnormal_nervous_system1.50448561
54MP0005085_abnormal_gallbladder_physiolo1.48975978
55MP0002733_abnormal_thermal_nociception1.48446793
56MP0002282_abnormal_trachea_morphology1.47804953
57MP0003890_abnormal_embryonic-extraembry1.46277881
58MP0002160_abnormal_reproductive_system1.43872246
59MP0005501_abnormal_skin_physiology1.41777352
60MP0000955_abnormal_spinal_cord1.39618671
61MP0000372_irregular_coat_pigmentation1.39610349
62MP0002090_abnormal_vision1.38271391
63MP0003195_calcinosis1.37959050
64MP0003942_abnormal_urinary_system1.36715863
65MP0002735_abnormal_chemical_nociception1.36446842
66MP0005408_hypopigmentation1.35850433
67MP0003880_abnormal_central_pattern1.35493008
68MP0005275_abnormal_skin_tensile1.33677378
69MP0003690_abnormal_glial_cell1.31535974
70MP0000467_abnormal_esophagus_morphology1.30468720
71MP0000613_abnormal_salivary_gland1.30467548
72MP0000537_abnormal_urethra_morphology1.27183878
73MP0004134_abnormal_chest_morphology1.25179149
74MP0000383_abnormal_hair_follicle1.25084994
75MP0002876_abnormal_thyroid_physiology1.24834679
76MP0002736_abnormal_nociception_after1.23923028
77MP0008789_abnormal_olfactory_epithelium1.23417276
78MP0003937_abnormal_limbs/digits/tail_de1.22035834
79MP0001188_hyperpigmentation1.21430716
80MP0003635_abnormal_synaptic_transmissio1.20782765
81MP0001970_abnormal_pain_threshold1.20433226
82MP0004859_abnormal_synaptic_plasticity1.19653994
83MP0002272_abnormal_nervous_system1.19641684
84MP0004145_abnormal_muscle_electrophysio1.18358283
85MP0002882_abnormal_neuron_morphology1.18190908
86MP0002752_abnormal_somatic_nervous1.17326880
87MP0001968_abnormal_touch/_nociception1.17081993
88MP0001348_abnormal_lacrimal_gland1.16403995
89MP0001340_abnormal_eyelid_morphology1.15505939
90MP0002063_abnormal_learning/memory/cond1.15403479
91MP0002234_abnormal_pharynx_morphology1.14089197
92MP0002184_abnormal_innervation1.13661430
93MP0009053_abnormal_anal_canal1.11938008
94MP0001486_abnormal_startle_reflex1.11401421
95MP0000604_amyloidosis1.11061529
96MP0002295_abnormal_pulmonary_circulatio1.10803557
97MP0003315_abnormal_perineum_morphology1.10519261
98MP0004885_abnormal_endolymph1.10516163
99MP0004858_abnormal_nervous_system1.09862342
100MP0010771_integument_phenotype1.09630638
101MP0000631_abnormal_neuroendocrine_gland1.08887178
102MP0001502_abnormal_circadian_rhythm1.08507328
103MP0000762_abnormal_tongue_morphology1.08358293
104MP0002938_white_spotting1.06752993
105MP0009745_abnormal_behavioral_response1.06633955
106MP0009250_abnormal_appendicular_skeleto1.05310786
107MP0000026_abnormal_inner_ear1.05200516
108MP0003385_abnormal_body_wall1.04382383
109MP0002249_abnormal_larynx_morphology1.01863803
110MP0000003_abnormal_adipose_tissue1.00393148
111MP0003938_abnormal_ear_development0.98508848
112MP0005195_abnormal_posterior_eye0.97295551
113MP0002064_seizures0.97014241
114MP0003283_abnormal_digestive_organ0.95885691
115MP0010678_abnormal_skin_adnexa0.95612763
116MP0000579_abnormal_nail_morphology0.94969974
117MP0002229_neurodegeneration0.94219026
118MP0002069_abnormal_eating/drinking_beha0.91373731
119MP0001440_abnormal_grooming_behavior0.90172605
120MP0001243_abnormal_dermal_layer0.90016321
121MP0001299_abnormal_eye_distance/0.89994235
122MP0001286_abnormal_eye_development0.89387332
123MP0002233_abnormal_nose_morphology0.89330821
124MP0001984_abnormal_olfaction0.88700778
125MP0001485_abnormal_pinna_reflex0.88463006
126MP0003631_nervous_system_phenotype0.88211886
127MP0004130_abnormal_muscle_cell0.86897847
128MP0005409_darkened_coat_color0.85717483
129MP0002067_abnormal_sensory_capabilities0.85431140
130MP0005389_reproductive_system_phenotype0.85337402
131MP0002152_abnormal_brain_morphology0.85089557
132MP0003119_abnormal_digestive_system0.84857731
133MP0008875_abnormal_xenobiotic_pharmacok0.84839167
134MP0003861_abnormal_nervous_system0.84567140
135MP0009046_muscle_twitch0.83864319
136MP0005551_abnormal_eye_electrophysiolog0.82667703
137MP0000678_abnormal_parathyroid_gland0.82304863
138MP0003718_maternal_effect0.81904187
139MP0002066_abnormal_motor_capabilities/c0.81760857
140MP0001324_abnormal_eye_pigmentation0.81527637
141MP0002092_abnormal_eye_morphology0.80779703
142MP0005410_abnormal_fertilization0.80302909
143MP0003755_abnormal_palate_morphology0.79187433
144MP0005365_abnormal_bile_salt0.79128452
145MP0002098_abnormal_vibrissa_morphology0.77900635
146MP0002116_abnormal_craniofacial_bone0.77666141
147MP0004811_abnormal_neuron_physiology0.77482910
148MP0000534_abnormal_ureter_morphology0.77137618
149MP0002102_abnormal_ear_morphology0.76972118
150MP0004272_abnormal_basement_membrane0.75970559
151MP0001944_abnormal_pancreas_morphology0.75045407
152MP0002572_abnormal_emotion/affect_behav0.74523339
153MP0002557_abnormal_social/conspecific_i0.73054199
154MP0005332_abnormal_amino_acid0.72562754
155MP0008877_abnormal_DNA_methylation0.71997138

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)5.81233269
2Termporal pattern (HP:0011008)5.22340989
3Insidious onset (HP:0003587)5.22340989
4Neurofibrillary tangles (HP:0002185)4.87817516
5Absent/shortened dynein arms (HP:0200106)4.73734863
6Dynein arm defect of respiratory motile cilia (HP:0012255)4.73734863
7Down-sloping shoulders (HP:0200021)4.68002842
8Conjugated hyperbilirubinemia (HP:0002908)4.56980027
9Shawl scrotum (HP:0000049)4.43125402
10Sensory axonal neuropathy (HP:0003390)4.40841112
11Abnormal respiratory motile cilium morphology (HP:0005938)4.38675052
12Abnormal respiratory epithelium morphology (HP:0012253)4.38675052
13Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.33383618
14Degeneration of the lateral corticospinal tracts (HP:0002314)4.33383618
15Increased serum pyruvate (HP:0003542)4.21192492
16Abnormality of glycolysis (HP:0004366)4.21192492
17Hypoplastic pelvis (HP:0008839)4.07872910
18Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.83312233
19Abnormal ciliary motility (HP:0012262)3.79570657
20High anterior hairline (HP:0009890)3.74040155
21Congenital ichthyosiform erythroderma (HP:0007431)3.72059912
22Cerebral inclusion bodies (HP:0100314)3.71836738
23Aplasia/Hypoplasia of the sacrum (HP:0008517)3.65185024
24Abnormality of the corticospinal tract (HP:0002492)3.48337548
25Reticulocytopenia (HP:0001896)3.42672317
26Breast hypoplasia (HP:0003187)3.23050317
27Abnormality of aromatic amino acid family metabolism (HP:0004338)3.11001614
28Fragile nails (HP:0001808)3.06345875
29Hyperthyroidism (HP:0000836)3.01383606
30Renal Fanconi syndrome (HP:0001994)2.98842771
31Limb dystonia (HP:0002451)2.95975862
32Neuroendocrine neoplasm (HP:0100634)2.95598858
33Acute necrotizing encephalopathy (HP:0006965)2.95336849
34Abnormal respiratory motile cilium physiology (HP:0012261)2.92818801
35Abnormal hair whorl (HP:0010721)2.89390584
36Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.83914565
37Gait imbalance (HP:0002141)2.83015495
38Leukodystrophy (HP:0002415)2.78468175
39Medial flaring of the eyebrow (HP:0010747)2.76627805
40Hypoparathyroidism (HP:0000829)2.76093431
41Prolonged neonatal jaundice (HP:0006579)2.69237215
42Myokymia (HP:0002411)2.66960421
43Abnormality of reticulocytes (HP:0004312)2.66865246
44Pheochromocytoma (HP:0002666)2.65975781
45Polyphagia (HP:0002591)2.65057363
46Intrahepatic cholestasis (HP:0001406)2.63541519
47Agitation (HP:0000713)2.63297595
48Rib fusion (HP:0000902)2.62610565
49Abnormality of alanine metabolism (HP:0010916)2.62579553
50Hyperalaninemia (HP:0003348)2.62579553
51Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.62579553
52Hyperphosphatemia (HP:0002905)2.61684497
53Acute encephalopathy (HP:0006846)2.61289907
54Progressive external ophthalmoplegia (HP:0000590)2.61016899
55Cerebral hypomyelination (HP:0006808)2.57341450
56Birth length less than 3rd percentile (HP:0003561)2.56937596
57Hyperglycinemia (HP:0002154)2.56580641
58Congenital primary aphakia (HP:0007707)2.56160702
59Premature rupture of membranes (HP:0001788)2.56022676
60Midline defect of the nose (HP:0004122)2.55441996
61Increased hepatocellular lipid droplets (HP:0006565)2.52691444
62Anomalous pulmonary venous return (HP:0010772)2.49853685
63Autoamputation (HP:0001218)2.47930821
64Abnormal auditory evoked potentials (HP:0006958)2.44010599
65Supernumerary spleens (HP:0009799)2.42879650
66Confusion (HP:0001289)2.40923706
67Stridor (HP:0010307)2.39838526
68Onion bulb formation (HP:0003383)2.39206181
69Xanthomatosis (HP:0000991)2.37907683
70Mitochondrial inheritance (HP:0001427)2.37792893
71Poor suck (HP:0002033)2.36854486
72Supranuclear gaze palsy (HP:0000605)2.35100501
73Lissencephaly (HP:0001339)2.33677705
74Cerebral hemorrhage (HP:0001342)2.33076272
75Reticulocytosis (HP:0001923)2.30956634
76Abnormality of the aortic arch (HP:0012303)2.30663762
77Abnormal mitochondria in muscle tissue (HP:0008316)2.29858268
78Lipid accumulation in hepatocytes (HP:0006561)2.29209360
79Deep venous thrombosis (HP:0002625)2.28532682
80Septo-optic dysplasia (HP:0100842)2.25209995
81Cerebral edema (HP:0002181)2.22698103
82Generalized aminoaciduria (HP:0002909)2.22189718
83Pachygyria (HP:0001302)2.22176187
84Anosmia (HP:0000458)2.21427971
85Abnormality of the phalanges of the 2nd finger (HP:0009541)2.18770550
86Maternal diabetes (HP:0009800)2.18114768
87Abnormality of dentin (HP:0010299)2.17728934
88Spastic paraparesis (HP:0002313)2.16680477
89Pendular nystagmus (HP:0012043)2.14514104
90Chronic bronchitis (HP:0004469)2.14334947
91Progressive macrocephaly (HP:0004481)2.12686112
92Infantile muscular hypotonia (HP:0008947)2.12219298
93Hepatocellular necrosis (HP:0001404)2.11643545
94Long clavicles (HP:0000890)2.10654458
95Abnormality of the pulmonary veins (HP:0011718)2.08245069
96Action tremor (HP:0002345)2.07690104
97Ulnar claw (HP:0001178)2.07201279
98Adrenal hypoplasia (HP:0000835)2.07183749
99Morphological abnormality of the pyramidal tract (HP:0002062)2.05723777
100Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.04675807
101Steppage gait (HP:0003376)2.03756690
102External ophthalmoplegia (HP:0000544)2.02335335
103Ileus (HP:0002595)2.01979697
104Hip dysplasia (HP:0001385)2.01122762
105Poor coordination (HP:0002370)2.00716672
106Spastic gait (HP:0002064)2.00377187
107Vaginal atresia (HP:0000148)2.00324067
108Erythroderma (HP:0001019)1.99845927
109Segmental peripheral demyelination/remyelination (HP:0003481)1.98537709
110Peripheral hypomyelination (HP:0007182)1.98097968
1113-Methylglutaconic aciduria (HP:0003535)1.97586261
112Anencephaly (HP:0002323)1.97358457
113Specific learning disability (HP:0001328)1.97297445
114Myelomeningocele (HP:0002475)1.96243476
115Asplenia (HP:0001746)1.95956997
116Absent septum pellucidum (HP:0001331)1.95939650
117Small hand (HP:0200055)1.95873347
118Pterygium (HP:0001059)1.95563453
119Neonatal respiratory distress (HP:0002643)1.95518358
120Foot dorsiflexor weakness (HP:0009027)1.94096133
121Amblyopia (HP:0000646)1.93066866
122Genital tract atresia (HP:0001827)1.91112501
123Aplasia/Hypoplasia of the brainstem (HP:0007362)1.91038902
124Hypoplasia of the brainstem (HP:0002365)1.91038902
125Long palpebral fissure (HP:0000637)1.90806887
126Septate vagina (HP:0001153)1.89533316
127Turricephaly (HP:0000262)1.87595558
128Ridged nail (HP:0001807)1.86798226
129Papilledema (HP:0001085)1.86738156
130Optic nerve coloboma (HP:0000588)1.85336398
131Akinesia (HP:0002304)1.84641400
132Epidermoid cyst (HP:0200040)1.83417790
133Ankle clonus (HP:0011448)1.82987411
134Coronal craniosynostosis (HP:0004440)1.82969693
135Hypobetalipoproteinemia (HP:0003563)1.82489452
136Abnormality of the right ventricle (HP:0001707)1.81764832
137Pancreatic fibrosis (HP:0100732)1.80273667
138Woolly hair (HP:0002224)1.80259867
139Respiratory distress (HP:0002098)1.80244525
140Hypophosphatemic rickets (HP:0004912)1.78363983
141Seborrheic dermatitis (HP:0001051)1.78036761
142Anophthalmia (HP:0000528)1.77937451
143Constricted visual fields (HP:0001133)1.77665782
144Abnormality of magnesium homeostasis (HP:0004921)1.77524312
145Rhinitis (HP:0012384)1.76153532
146Abnormality of midbrain morphology (HP:0002418)1.75911049
147Molar tooth sign on MRI (HP:0002419)1.75911049
148Nephronophthisis (HP:0000090)1.74970377
149Hypogonadotrophic hypogonadism (HP:0000044)1.74220251
150Duplicated collecting system (HP:0000081)1.73934107
151Hammertoe (HP:0001765)1.73192158
152Increased CSF lactate (HP:0002490)1.73010623
153Chronic hepatic failure (HP:0100626)1.72685218
154Severe Myopia (HP:0011003)1.72662409
155Hyperlipoproteinemia (HP:0010980)1.71266596
156Renal tubular dysfunction (HP:0000124)1.71204915
157Exotropia (HP:0000577)1.71103522
158Abnormality of the foot musculature (HP:0001436)1.70767425
159Increased variability in muscle fiber diameter (HP:0003557)1.70575258
160Asymmetric growth (HP:0100555)1.70359277
161Aplasia/Hypoplasia of the spleen (HP:0010451)1.70222554
162Hepatic necrosis (HP:0002605)1.69913369
163Abnormality of placental membranes (HP:0011409)1.69623839
164Amniotic constriction ring (HP:0009775)1.69623839
165Hypoplastic left heart (HP:0004383)1.68582048
166Abnormality of the septum pellucidum (HP:0007375)1.68331388
167Decreased electroretinogram (ERG) amplitude (HP:0000654)1.67542352
168Retinal dysplasia (HP:0007973)1.67286400
169Osteomalacia (HP:0002749)1.66430974
170Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.66179478
171Nephrogenic diabetes insipidus (HP:0009806)1.65816664
172Hypoplasia of the corpus callosum (HP:0002079)1.65311495
173Meningocele (HP:0002435)1.65253289
174Abnormality of cells of the erythroid lineage (HP:0012130)1.64951388
175Hypoplastic female external genitalia (HP:0012815)1.63982873
176Abnormality of the 2nd finger (HP:0004100)1.62967645
177Hepatoblastoma (HP:0002884)1.62849044
178True hermaphroditism (HP:0010459)1.62245986
179Failure to thrive in infancy (HP:0001531)1.61856849
180Abnormality of the labia minora (HP:0012880)1.61735691
181Partial agenesis of the corpus callosum (HP:0001338)1.61573524
182Hypertensive crisis (HP:0100735)1.58859144
183Distal sensory impairment (HP:0002936)1.56136243
184Delusions (HP:0000746)1.56073587
185Abnormality of the alveolar ridges (HP:0006477)1.55013102
186Megalencephaly (HP:0001355)1.54383363
187Hyperphosphaturia (HP:0003109)1.54037212

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.16526975
2LIMK13.78465462
3TESK22.86634172
4BCR2.82040392
5EPHB12.77201173
6MARK12.70094957
7UHMK12.61282590
8OXSR12.56205513
9DYRK22.55779919
10PBK2.29983471
11PKN12.17106183
12NTRK12.05439616
13CSNK1G32.04364366
14MAP3K112.02945771
15TLK12.02541153
16WNK31.99123373
17BRAF1.97386293
18MAP2K71.89245501
19MET1.87836951
20NME21.84886468
21MAPKAPK51.72860128
22DMPK1.71482655
23TESK11.71049167
24MAP3K91.66056327
25EPHB21.60868011
26RPS6KA21.60781136
27FGFR21.58305635
28NTRK31.50175298
29NTRK21.48631516
30CSNK1G11.48303099
31CDC71.48284733
32CSNK1A1L1.45453993
33BUB11.44593896
34CDK191.43926460
35MAP3K41.42796896
36CSNK1G21.36145117
37MAP2K21.34408661
38PINK11.33755292
39WNK41.31596135
40ROCK21.30874147
41CDK141.22572532
42PRKCI1.22064859
43MAPK131.21068594
44FGR1.20964366
45MAP3K61.20222455
46BRSK11.18269281
47LATS21.17689650
48TYRO31.17303664
49PAK31.16984254
50NUAK11.15274432
51STK111.12982031
52CASK1.10471044
53CAMK2B1.06440789
54PAK61.05930017
55DDR21.05149260
56AURKA1.04570016
57ICK1.02763901
58PNCK0.99924587
59CDK150.96664750
60MST40.96362127
61NEK20.95692701
62CDK180.94572113
63PIM20.93346196
64PRKCG0.93188650
65CAMK1D0.90599600
66PHKG10.89363766
67PHKG20.89363766
68CLK10.88523877
69CDK11A0.88117483
70SIK20.86981264
71PRKCH0.86632502
72SGK30.85747631
73WNK10.84778692
74TRIB30.84770099
75ARAF0.83751292
76ERBB40.83651069
77MAP2K40.82118180
78MAP4K20.79932843
79STK160.79873968
80PAK10.79154755
81PTK60.78107345
82SGK20.76991550
83SGK4940.76912889
84SGK2230.76912889
85CAMK2D0.73875889
86RPS6KA60.73738519
87MINK10.73227975
88CAMK2G0.72733167
89NME10.72680608
90RPS6KC10.72266561
91RPS6KL10.72266561
92CAMK2A0.71316773
93DYRK30.70902328
94EPHA20.69277262
95RPS6KA50.67686471
96PLK10.66578526
97VRK20.66276878
98ABL20.66130264
99ADRBK10.65492769
100MAPK150.65433143
101PRKD30.64938226
102CAMK1G0.64101675
103PIK3CA0.62981130
104PRKD10.59989392
105RPS6KB20.59944941
106MAP2K10.58813181
107PRKD20.58666139
108PRKCE0.58565774
109BMPR1B0.57527082
110BCKDK0.57317001
111GRK50.57099839
112CAMK10.56332745
113PLK20.55138170
114DAPK30.53605630
115DYRK1B0.53029682
116CDK50.52915090
117TNIK0.51979123
118SIK10.51080264
119ERBB20.51075815
120GSK3A0.50571321
121CSNK1E0.50164254
122CDK70.50100126
123ROCK10.48568370
124PRKCD0.48535700
125PRKCZ0.48485486
126PIK3CG0.48402125
127ADRBK20.48217697
128BLK0.48179080
129RPS6KA10.48079511
130SMG10.47684467
131RAF10.46691653
132PAK20.46514813
133MARK20.45976289
134PRKAA10.45940225
135PRKACA0.45488252
136BMX0.44788300
137CAMKK10.43946420
138LMTK20.43669629
139PTK20.41501034
140AKT10.41216909
141FYN0.39150736
142SGK10.38986936
143CSNK1A10.37326286
144MAPK80.36927131
145CDK10.36598794
146MAP3K80.36234318
147MAPK40.36168772
148AURKB0.36067726
149DYRK1A0.34224125
150MAPKAPK20.33285652
151SRPK10.31217346
152MAP2K60.30840182
153ILK0.30555506

Predicted pathways (KEGG)

RankGene SetZ-score
1* Terpenoid backbone biosynthesis_Homo sapiens_hsa009006.17221387
2Steroid biosynthesis_Homo sapiens_hsa001005.95439257
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.93281901
4Fatty acid elongation_Homo sapiens_hsa000623.58677758
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.33068525
6Oxidative phosphorylation_Homo sapiens_hsa001902.37785223
7Butanoate metabolism_Homo sapiens_hsa006502.36065508
8Ribosome_Homo sapiens_hsa030102.03788780
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.02549697
10Sulfur metabolism_Homo sapiens_hsa009201.94333439
11Parkinsons disease_Homo sapiens_hsa050121.88600863
12Ether lipid metabolism_Homo sapiens_hsa005651.86448300
13Histidine metabolism_Homo sapiens_hsa003401.76061714
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.75815892
15Nicotine addiction_Homo sapiens_hsa050331.61883614
16Synaptic vesicle cycle_Homo sapiens_hsa047211.60545688
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.59962039
18Phototransduction_Homo sapiens_hsa047441.57430623
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.53218101
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.52566468
21Alzheimers disease_Homo sapiens_hsa050101.51144952
22Linoleic acid metabolism_Homo sapiens_hsa005911.49966114
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49650994
24Tyrosine metabolism_Homo sapiens_hsa003501.46866434
25Fatty acid metabolism_Homo sapiens_hsa012121.40463431
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.36764657
27Sulfur relay system_Homo sapiens_hsa041221.36441316
28Proteasome_Homo sapiens_hsa030501.34411202
29Axon guidance_Homo sapiens_hsa043601.28297015
30Sphingolipid metabolism_Homo sapiens_hsa006001.26121104
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.24195054
32Arginine and proline metabolism_Homo sapiens_hsa003301.23332105
33Chemical carcinogenesis_Homo sapiens_hsa052041.19438950
34Glutamatergic synapse_Homo sapiens_hsa047241.19171495
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.18450405
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.17768570
37Morphine addiction_Homo sapiens_hsa050321.17440054
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16085497
39Tryptophan metabolism_Homo sapiens_hsa003801.10461319
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.09805128
41Galactose metabolism_Homo sapiens_hsa000521.08344748
42Huntingtons disease_Homo sapiens_hsa050161.07379957
43Glutathione metabolism_Homo sapiens_hsa004801.07037975
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06772511
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.06113740
46Fatty acid degradation_Homo sapiens_hsa000711.05639553
47Folate biosynthesis_Homo sapiens_hsa007901.02910277
48Retinol metabolism_Homo sapiens_hsa008301.02178210
49Dopaminergic synapse_Homo sapiens_hsa047281.00491159
50* Peroxisome_Homo sapiens_hsa041460.99885349
51Pyruvate metabolism_Homo sapiens_hsa006200.98709989
52Fat digestion and absorption_Homo sapiens_hsa049750.97786228
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.97331305
54Propanoate metabolism_Homo sapiens_hsa006400.92851888
55Phenylalanine metabolism_Homo sapiens_hsa003600.91692947
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90254093
57Circadian entrainment_Homo sapiens_hsa047130.84353837
58Cholinergic synapse_Homo sapiens_hsa047250.83467903
59Protein export_Homo sapiens_hsa030600.78926452
60One carbon pool by folate_Homo sapiens_hsa006700.77889425
61Nitrogen metabolism_Homo sapiens_hsa009100.77120609
62Arachidonic acid metabolism_Homo sapiens_hsa005900.76801809
63Notch signaling pathway_Homo sapiens_hsa043300.72977297
64Caffeine metabolism_Homo sapiens_hsa002320.72250836
65Base excision repair_Homo sapiens_hsa034100.71360143
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71278447
67Basal cell carcinoma_Homo sapiens_hsa052170.69914710
68PPAR signaling pathway_Homo sapiens_hsa033200.68753666
69Basal transcription factors_Homo sapiens_hsa030220.67752285
70Complement and coagulation cascades_Homo sapiens_hsa046100.67336962
71* Metabolic pathways_Homo sapiens_hsa011000.66931378
72Starch and sucrose metabolism_Homo sapiens_hsa005000.66683296
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66570603
74Hedgehog signaling pathway_Homo sapiens_hsa043400.66451048
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.64611580
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62004389
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58675955
78Arginine biosynthesis_Homo sapiens_hsa002200.58279664
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57158920
80Lysine degradation_Homo sapiens_hsa003100.56945546
81Serotonergic synapse_Homo sapiens_hsa047260.56029214
82beta-Alanine metabolism_Homo sapiens_hsa004100.50905423
83Vitamin B6 metabolism_Homo sapiens_hsa007500.49829822
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49638683
85Insulin secretion_Homo sapiens_hsa049110.47511475
86Tight junction_Homo sapiens_hsa045300.47330111
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46414790
88Glycerolipid metabolism_Homo sapiens_hsa005610.46077153
89Fatty acid biosynthesis_Homo sapiens_hsa000610.45973716
90Bile secretion_Homo sapiens_hsa049760.44245348
91Regulation of autophagy_Homo sapiens_hsa041400.42233313
92Selenocompound metabolism_Homo sapiens_hsa004500.40749679
93Vibrio cholerae infection_Homo sapiens_hsa051100.40570690
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.40346231
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38887735
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38527265
97AMPK signaling pathway_Homo sapiens_hsa041520.37796477
98Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36770593
99Cardiac muscle contraction_Homo sapiens_hsa042600.36122763
100Vitamin digestion and absorption_Homo sapiens_hsa049770.35272643
101Phagosome_Homo sapiens_hsa041450.34766028
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.34156412
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.32879178
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31232304
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31202976
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.30824308
107RNA polymerase_Homo sapiens_hsa030200.29790145
108Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27804839
109ECM-receptor interaction_Homo sapiens_hsa045120.27233216
110Prion diseases_Homo sapiens_hsa050200.26886830
111Cocaine addiction_Homo sapiens_hsa050300.26762386
112Ovarian steroidogenesis_Homo sapiens_hsa049130.26530130
113Gap junction_Homo sapiens_hsa045400.26050739
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24968327
115Hippo signaling pathway_Homo sapiens_hsa043900.22455609
116Biosynthesis of amino acids_Homo sapiens_hsa012300.22196328
117Melanogenesis_Homo sapiens_hsa049160.20205363
118Alcoholism_Homo sapiens_hsa050340.19790088
119Cysteine and methionine metabolism_Homo sapiens_hsa002700.17665791
120Carbon metabolism_Homo sapiens_hsa012000.17298288
121Collecting duct acid secretion_Homo sapiens_hsa049660.17123357
122Long-term depression_Homo sapiens_hsa047300.16748098
123Renal cell carcinoma_Homo sapiens_hsa052110.16145304
1242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.15851072
125Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.14446420
126Endocytosis_Homo sapiens_hsa041440.11029296
127Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.10243431
128PI3K-Akt signaling pathway_Homo sapiens_hsa041510.08544083
129GABAergic synapse_Homo sapiens_hsa047270.08423243
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.07997597

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