MUSK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a muscle-specific tyrosine kinase receptor. The encoded protein may play a role in clustering of the acetylcholine receptor in the postsynaptic neuromuscular junction. Mutations in this gene have been associated with congenital myasthenic syndrome. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1muscle cell cellular homeostasis (GO:0046716)8.90817939
2heart process (GO:0003015)7.32596245
3heart contraction (GO:0060047)7.32596245
4striated muscle atrophy (GO:0014891)7.07009163
5negative regulation of nitric-oxide synthase activity (GO:0051001)6.95153460
6negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.91249365
7actin-myosin filament sliding (GO:0033275)6.74123673
8muscle filament sliding (GO:0030049)6.74123673
9regulation of skeletal muscle contraction (GO:0014819)6.73398723
10muscle atrophy (GO:0014889)6.33536161
11actin-mediated cell contraction (GO:0070252)6.14070393
12muscle cell fate commitment (GO:0042693)6.12242641
13cardiac myofibril assembly (GO:0055003)6.03262240
14response to muscle activity (GO:0014850)6.03056399
15regulation of sarcomere organization (GO:0060297)6.00889106
16negative regulation of potassium ion transmembrane transport (GO:1901380)5.93849759
17negative regulation of protein localization to cell surface (GO:2000009)5.84326216
18membrane raft organization (GO:0031579)5.74307842
19multicellular organismal movement (GO:0050879)5.69114524
20musculoskeletal movement (GO:0050881)5.69114524
21plasma membrane repair (GO:0001778)5.62142732
22proteasome assembly (GO:0043248)5.53792943
23negative regulation of muscle hypertrophy (GO:0014741)5.47691121
24response to gravity (GO:0009629)5.43218798
25ribosomal small subunit assembly (GO:0000028)5.35485028
26myofibril assembly (GO:0030239)5.32421618
27sarcomere organization (GO:0045214)5.24248093
28skeletal muscle tissue development (GO:0007519)5.02091353
29skeletal muscle tissue regeneration (GO:0043403)4.89288826
30platelet dense granule organization (GO:0060155)4.84395820
31facial nerve structural organization (GO:0021612)4.76335996
32myoblast fusion (GO:0007520)4.75418323
33myotube cell development (GO:0014904)4.69807259
34DNA deamination (GO:0045006)4.64289938
35membrane assembly (GO:0071709)4.50970301
36actin filament-based movement (GO:0030048)4.47164790
37negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.46565731
38negative regulation of T-helper cell differentiation (GO:0045623)4.46565731
39skeletal muscle adaptation (GO:0043501)4.37664539
40definitive hemopoiesis (GO:0060216)4.32608368
41regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.29205847
42lymphoid progenitor cell differentiation (GO:0002320)4.23955389
43muscle tissue morphogenesis (GO:0060415)4.16483703
44actomyosin structure organization (GO:0031032)4.15681118
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.10870280
46regulation of integrin-mediated signaling pathway (GO:2001044)4.10256815
47respiratory chain complex IV assembly (GO:0008535)4.05678007
48syncytium formation by plasma membrane fusion (GO:0000768)4.04275970
49positive regulation of myoblast differentiation (GO:0045663)3.99627313
50muscle organ development (GO:0007517)3.99616124
51positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.96626591
52negative regulation of monooxygenase activity (GO:0032769)3.94390362
53negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.94266086
54negative regulation of heart growth (GO:0061117)3.92055192
55negative regulation of cardiac muscle tissue growth (GO:0055022)3.92055192
56actin filament depolymerization (GO:0030042)3.91066501
57muscle structure development (GO:0061061)3.90029324
58regulation of RIG-I signaling pathway (GO:0039535)3.89427625
59regulation of female gonad development (GO:2000194)3.84178058
60regulation of muscle hypertrophy (GO:0014743)3.81533477
61response to interferon-beta (GO:0035456)3.77431577
62negative regulation of B cell apoptotic process (GO:0002903)3.77073758
63maturation of 5.8S rRNA (GO:0000460)3.72430149
64positive regulation of myotube differentiation (GO:0010831)3.70993142
65muscle fiber development (GO:0048747)3.62730048
66syncytium formation (GO:0006949)3.62431432
67regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.60615926
68positive regulation of granulocyte differentiation (GO:0030854)3.60565572
69cardiac muscle tissue morphogenesis (GO:0055008)3.56755520
70negative regulation of cardiac muscle tissue development (GO:0055026)3.55718662
71striated muscle tissue development (GO:0014706)3.52930693
72maturation of SSU-rRNA (GO:0030490)3.51011295
73positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.50486312
74striated muscle contraction (GO:0006941)3.48660709
75regulation of cardiac muscle cell differentiation (GO:2000725)3.45724343
76regulation of triglyceride catabolic process (GO:0010896)3.42856841
77regulation of striated muscle contraction (GO:0006942)3.41021257
78postsynaptic membrane organization (GO:0001941)3.40328353
79regulation of membrane repolarization (GO:0060306)3.39624182
80neuromuscular synaptic transmission (GO:0007274)3.38789889
81viral transcription (GO:0019083)3.35898742
82cranial nerve structural organization (GO:0021604)3.33732548
83piRNA metabolic process (GO:0034587)3.32422960
84cardiac muscle cell development (GO:0055013)3.29438662
85high-density lipoprotein particle remodeling (GO:0034375)3.27488058
86embryonic cranial skeleton morphogenesis (GO:0048701)3.25931995
87behavioral response to ethanol (GO:0048149)3.25733833
88ribosomal small subunit biogenesis (GO:0042274)3.25559056
89negative regulation of erythrocyte differentiation (GO:0045647)3.25155718
90striated muscle cell development (GO:0055002)3.24219696
91striated muscle adaptation (GO:0014888)3.23687369
92response to interferon-alpha (GO:0035455)3.22923512
93cardiac muscle contraction (GO:0060048)3.20199389
94translational termination (GO:0006415)3.19938259
95negative regulation of alpha-beta T cell differentiation (GO:0046639)3.19206894
96muscle tissue development (GO:0060537)3.18312408
97myoblast migration (GO:0051451)3.17326731
98cellular response to dexamethasone stimulus (GO:0071549)3.15560914
99immunoglobulin mediated immune response (GO:0016064)3.15014932
100negative regulation of type 2 immune response (GO:0002829)3.14393043
101negative regulation of cell size (GO:0045792)3.13529794
102positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.13321192
103vascular smooth muscle contraction (GO:0014829)3.11629248
104positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.10948664
105regulation of histone H3-K27 methylation (GO:0061085)3.10444546
106regulation of transforming growth factor beta2 production (GO:0032909)3.10226169
107myotube differentiation (GO:0014902)3.09647425
108regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.08700031
109positive regulation of megakaryocyte differentiation (GO:0045654)3.08638548
110regulation of action potential (GO:0098900)3.08619243
111myelination in peripheral nervous system (GO:0022011)3.06686673
112peripheral nervous system axon ensheathment (GO:0032292)3.06686673
113regulation of alkaline phosphatase activity (GO:0010692)3.06099334
114cytochrome complex assembly (GO:0017004)3.05831567
115negative regulation of cardiac muscle hypertrophy (GO:0010614)3.05431112
116Rac protein signal transduction (GO:0016601)3.04765828
117regulation of meiosis I (GO:0060631)3.02619067
118mature B cell differentiation involved in immune response (GO:0002313)2.99857598
119muscle contraction (GO:0006936)2.98784235
120positive regulation of T cell mediated cytotoxicity (GO:0001916)2.98255656
121phospholipid scrambling (GO:0017121)2.96664107
122barbed-end actin filament capping (GO:0051016)2.96045193
123exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.95167502
124cranial nerve morphogenesis (GO:0021602)2.93979845
125cardiac cell development (GO:0055006)2.93935090
126motile cilium assembly (GO:0044458)2.91773449
127regulation of cardiac muscle hypertrophy (GO:0010611)2.91283564
128peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.91004624
129positive regulation of actin filament depolymerization (GO:0030836)2.90761618
130response to dexamethasone (GO:0071548)2.89798218
131response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.89612665
132regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.88151166
133positive regulation of mitochondrial fission (GO:0090141)2.87907977
134negative regulation of skeletal muscle tissue development (GO:0048642)2.87552498
135regulation of muscle adaptation (GO:0043502)2.85493018
136GPI anchor biosynthetic process (GO:0006506)2.85438087
137skeletal muscle fiber development (GO:0048741)2.82185979
138SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.81315724
139mature B cell differentiation (GO:0002335)2.80454936
140reverse cholesterol transport (GO:0043691)2.80338788
141muscle system process (GO:0003012)2.80239542
142CENP-A containing nucleosome assembly (GO:0034080)2.78522337
143T cell lineage commitment (GO:0002360)2.77440808
144phospholipid efflux (GO:0033700)2.77359943
145regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.77106831
146cotranslational protein targeting to membrane (GO:0006613)2.76962498
147centriole replication (GO:0007099)2.76741234
148nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.76438133
149muscle cell development (GO:0055001)2.76409537
150L-fucose catabolic process (GO:0042355)2.75971599
151fucose catabolic process (GO:0019317)2.75971599
152L-fucose metabolic process (GO:0042354)2.75971599
153meiotic chromosome segregation (GO:0045132)2.75209656
154cartilage morphogenesis (GO:0060536)2.74544885
155generation of neurons (GO:0048699)2.74397606
156protein localization to endoplasmic reticulum (GO:0070972)2.73853247
157protein targeting to ER (GO:0045047)2.72055442
158response to inactivity (GO:0014854)2.68866536
159RNA methylation (GO:0001510)2.68200937
160response to folic acid (GO:0051593)2.66353391
161regulation of memory T cell differentiation (GO:0043380)2.64215581
162translational elongation (GO:0006414)2.63972217
163centriole assembly (GO:0098534)2.63584926
164regulation of relaxation of muscle (GO:1901077)2.62071430
165oocyte maturation (GO:0001556)2.61612738
166megakaryocyte development (GO:0035855)2.60367590
167secretory granule organization (GO:0033363)2.59388217
168protein ADP-ribosylation (GO:0006471)2.58653139
169positive regulation of skeletal muscle tissue development (GO:0048643)2.58546170
170telomere maintenance via semi-conservative replication (GO:0032201)2.58423749
171regulation of metalloenzyme activity (GO:0048552)2.58365386
172skeletal muscle contraction (GO:0003009)2.57785741
173tRNA methylation (GO:0030488)2.57395645
174establishment of protein localization to endoplasmic reticulum (GO:0072599)2.57381509
175pseudouridine synthesis (GO:0001522)2.57158227
176germinal center formation (GO:0002467)2.56737880
177negative regulation of viral genome replication (GO:0045071)2.55202125
178defense response to protozoan (GO:0042832)2.54995194
179viral life cycle (GO:0019058)2.54796036
180peptidyl-threonine dephosphorylation (GO:0035970)2.53506311
181CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.53422855
182mitochondrial calcium ion transport (GO:0006851)2.52978856
183regulation of T cell mediated cytotoxicity (GO:0001914)2.52632257
184mannosylation (GO:0097502)2.52530136
185thyroid gland development (GO:0030878)2.51643871
186righting reflex (GO:0060013)2.49916057
187antigen processing and presentation via MHC class Ib (GO:0002475)2.49727784
188ubiquinone biosynthetic process (GO:0006744)2.49397385
189quinone biosynthetic process (GO:1901663)2.49397385
190telomere maintenance via recombination (GO:0000722)2.48381527
191preassembly of GPI anchor in ER membrane (GO:0016254)2.47666120
192negative regulation of B cell mediated immunity (GO:0002713)2.46917063
193negative regulation of immunoglobulin mediated immune response (GO:0002890)2.46917063
194B cell mediated immunity (GO:0019724)2.46847505

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.80635859
2SCL_19346495_ChIP-Seq_HPC-7_Human4.29643000
3EZH2_22144423_ChIP-Seq_EOC_Human3.87884069
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.74773733
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.49108041
6NOTCH1_21737748_ChIP-Seq_TLL_Human3.14736843
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.05527910
8LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.02425172
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.89363775
10ESR1_20079471_ChIP-ChIP_T-47D_Human2.72042149
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.70245211
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.68690070
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.59719364
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.58619530
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.54683771
16EP300_21415370_ChIP-Seq_HL-1_Mouse2.54445237
17PCGF2_27294783_Chip-Seq_ESCs_Mouse2.52248169
18IGF1R_20145208_ChIP-Seq_DFB_Human2.41186386
19IRF8_22096565_ChIP-ChIP_GC-B_Human2.31587669
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.30764888
21TP53_18474530_ChIP-ChIP_U2OS_Human2.26862609
22VDR_22108803_ChIP-Seq_LS180_Human2.26768151
23* CJUN_26792858_Chip-Seq_BT549_Human2.25631250
24* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.22398544
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.21522097
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.19773755
27* PIAS1_25552417_ChIP-Seq_VCAP_Human2.19159131
28KAP1_22055183_ChIP-Seq_ESCs_Mouse2.17415450
29* BRD4_25478319_ChIP-Seq_HGPS_Human2.16196280
30TP53_16413492_ChIP-PET_HCT116_Human2.14851980
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.13557722
32FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.09238596
33HOXB4_20404135_ChIP-ChIP_EML_Mouse2.04234918
34IRF1_19129219_ChIP-ChIP_H3396_Human2.03959308
35SRF_21415370_ChIP-Seq_HL-1_Mouse2.01076551
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.98990147
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.98276761
38TP63_19390658_ChIP-ChIP_HaCaT_Human1.96055042
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96028930
40MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.91519316
41* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.87631681
42* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.85550102
43NR3C1_21868756_ChIP-Seq_MCF10A_Human1.83185319
44TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.81312596
45MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.77909704
46NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.77735895
47NRF2_20460467_ChIP-Seq_MEFs_Mouse1.77735895
48LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.75880202
49* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.75176609
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74491812
51PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.74149271
52HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72721113
53RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72203500
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.70844801
55* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.70810426
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.67526436
57GABP_17652178_ChIP-ChIP_JURKAT_Human1.65792631
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.64401670
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64065809
60MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.63154534
61SMAD4_21799915_ChIP-Seq_A2780_Human1.62715815
62NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.61855317
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.57870433
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.57631653
65ELF1_17652178_ChIP-ChIP_JURKAT_Human1.57150659
66MYC_18555785_ChIP-Seq_MESCs_Mouse1.56854632
67HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.56341948
68LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55756715
69* BCAT_22108803_ChIP-Seq_LS180_Human1.55733347
70P300_19829295_ChIP-Seq_ESCs_Human1.55269298
71CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54901883
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.52835224
73CTNNB1_20460455_ChIP-Seq_HCT116_Human1.52702483
74TAF15_26573619_Chip-Seq_HEK293_Human1.49906136
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.47920307
76STAT6_21828071_ChIP-Seq_BEAS2B_Human1.47035427
77MYB_21317192_ChIP-Seq_ERMYB_Mouse1.46865069
78GATA1_22025678_ChIP-Seq_K562_Human1.46064667
79KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.44683029
80SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.42323458
81ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41995765
82FUS_26573619_Chip-Seq_HEK293_Human1.39962957
83RNF2_27304074_Chip-Seq_NSC_Mouse1.39688474
84STAT3_23295773_ChIP-Seq_U87_Human1.38591069
85CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.37829303
86SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36606874
87VDR_23849224_ChIP-Seq_CD4+_Human1.35720495
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35311081
89SPI1_23547873_ChIP-Seq_NB4_Human1.34895142
90GBX2_23144817_ChIP-Seq_PC3_Human1.32812255
91MYC_18940864_ChIP-ChIP_HL60_Human1.31884179
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31766267
93CBP_20019798_ChIP-Seq_JUKART_Human1.31766267
94FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31551198
95* CDX2_22108803_ChIP-Seq_LS180_Human1.28802795
96POU5F1_16153702_ChIP-ChIP_HESCs_Human1.27632538
97TBX20_22328084_ChIP-Seq_HEART_Mouse1.25744935
98TBX20_22080862_ChIP-Seq_HEART_Mouse1.25744935
99* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25063958
100OCT4_21477851_ChIP-Seq_ESCs_Mouse1.23029794
101TAL1_26923725_Chip-Seq_HPCs_Mouse1.22588662
102KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22553905
103CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.22396825
104JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.21916332
105EST1_17652178_ChIP-ChIP_JURKAT_Human1.21246528
106FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.21024772
107E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.19273892
108ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18628396
109* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17600020
110JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17371361
111E2F1_18555785_Chip-Seq_ESCs_Mouse1.16817684
112P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16432886
113SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15577138
114KDM2B_26808549_Chip-Seq_REH_Human1.13946341
115TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13649346
116UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13470090
117GATA2_21666600_ChIP-Seq_HMVEC_Human1.13265843
118EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12711048
119E2F7_22180533_ChIP-Seq_HELA_Human1.12523791
120STAT1_17558387_ChIP-Seq_HELA_Human1.12483388
121FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.12370189
122ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09252447
123EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.09047335
124EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08866277
125EWS_26573619_Chip-Seq_HEK293_Human1.08706657
126NMYC_18555785_Chip-Seq_ESCs_Mouse1.06358361
127STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.05860486
128CBX2_27304074_Chip-Seq_ESCs_Mouse1.05491583
129SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.05355817
130RUNX1_27457419_Chip-Seq_LIVER_Mouse1.05067767
131STAT3_18555785_Chip-Seq_ESCs_Mouse1.04963000
132RARG_19884340_ChIP-ChIP_MEFs_Mouse1.04773747
133FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.04555549
134CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04321552
135* ZNF274_21170338_ChIP-Seq_K562_Hela1.03965037
136SOX2_18555785_Chip-Seq_ESCs_Mouse1.03823363
137NANOG_18555785_Chip-Seq_ESCs_Mouse1.03743529
138FOXP3_21729870_ChIP-Seq_TREG_Human1.03648931
139TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.02748020
140* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02705277
141ER_23166858_ChIP-Seq_MCF-7_Human1.02672696
142RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01169575
143* TP63_23658742_ChIP-Seq_EP156T_Human1.00709798
144ELK1_19687146_ChIP-ChIP_HELA_Human1.00652257
145CRX_20693478_ChIP-Seq_RETINA_Mouse1.00030344
146TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99912820
147P53_22387025_ChIP-Seq_ESCs_Mouse0.98905672
148ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98722707
149CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.98287984
150* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98197313
151CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96942275
152WT1_19549856_ChIP-ChIP_CCG9911_Human0.96892836
153ETS1_22383799_ChIP-Seq_G1ME_Mouse0.96627541
154ZFX_18555785_Chip-Seq_ESCs_Mouse0.95998421
155OCT4_18555785_Chip-Seq_ESCs_Mouse0.95850605
156NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.95082950
157GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95037712
158SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93869604
159HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93818620
160SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.93086540
161FOXM1_26456572_ChIP-Seq_MCF-7_Human0.92202464
162SMAD1_18555785_Chip-Seq_ESCs_Mouse0.90802393
163CMYC_18555785_Chip-Seq_ESCs_Mouse0.90773260
164SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90568430
165CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90529297
166NANOG_19829295_ChIP-Seq_ESCs_Human0.90330303
167CTCF_18555785_Chip-Seq_ESCs_Mouse0.89334876
168GATA2_22383799_ChIP-Seq_G1ME_Mouse0.89216679
169RUNX_20019798_ChIP-Seq_JUKART_Human0.88619653
170STAT4_19710469_ChIP-ChIP_TH1__Mouse0.88610430
171BMI1_23680149_ChIP-Seq_NPCS_Mouse0.88401840
172P300_18555785_Chip-Seq_ESCs_Mouse0.87294386
173PCGF2_27294783_Chip-Seq_NPCs_Mouse0.86668398

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle4.06966509
2MP0006292_abnormal_olfactory_placode3.74608853
3MP0002234_abnormal_pharynx_morphology3.38869858
4MP0009379_abnormal_foot_pigmentation3.27322615
5MP0000749_muscle_degeneration3.25610705
6MP0003646_muscle_fatigue3.10887498
7MP0008438_abnormal_cutaneous_collagen3.01135860
8MP0000750_abnormal_muscle_regeneration2.84871133
9MP0009840_abnormal_foam_cell2.79588236
10MP0005360_urolithiasis2.70136423
11MP0009780_abnormal_chondrocyte_physiolo2.68792030
12MP0003705_abnormal_hypodermis_morpholog2.65914723
13MP0002269_muscular_atrophy2.64202253
14MP0004036_abnormal_muscle_relaxation2.57642156
15MP0001188_hyperpigmentation2.53921180
16MP0001299_abnormal_eye_distance/2.51542527
17MP0004087_abnormal_muscle_fiber2.49101037
18MP0002102_abnormal_ear_morphology2.48602181
19MP0002837_dystrophic_cardiac_calcinosis2.48425767
20MP0002108_abnormal_muscle_morphology2.45816768
21MP0002396_abnormal_hematopoietic_system2.37877997
22MP0002249_abnormal_larynx_morphology2.36574438
23MP0004272_abnormal_basement_membrane2.33879628
24MP0003136_yellow_coat_color2.28031911
25MP0005174_abnormal_tail_pigmentation2.26729113
26MP0003718_maternal_effect2.19980240
27MP0005075_abnormal_melanosome_morpholog2.05579205
28MP0003724_increased_susceptibility_to2.05232347
29MP0005451_abnormal_body_composition2.02556018
30MP0002163_abnormal_gland_morphology2.01819121
31MP0000372_irregular_coat_pigmentation1.98227096
32MP0004808_abnormal_hematopoietic_stem1.97942637
33MP0003191_abnormal_cellular_cholesterol1.96728901
34MP0005620_abnormal_muscle_contractility1.95259624
35* MP0000747_muscle_weakness1.93758085
36MP0000685_abnormal_immune_system1.88436438
37MP0004215_abnormal_myocardial_fiber1.85368756
38MP0004233_abnormal_muscle_weight1.84937151
39MP0005671_abnormal_response_to1.84710429
40MP0003279_aneurysm1.83927843
41MP0003763_abnormal_thymus_physiology1.80871171
42MP0005330_cardiomyopathy1.80536678
43MP0004147_increased_porphyrin_level1.79172445
44MP0010368_abnormal_lymphatic_system1.77871126
45MP0001835_abnormal_antigen_presentation1.75680144
46MP0002095_abnormal_skin_pigmentation1.72788547
47MP0001542_abnormal_bone_strength1.69316334
48MP0000733_abnormal_muscle_development1.67864774
49MP0005409_darkened_coat_color1.67519960
50MP0003045_fibrosis1.67026815
51MP0004381_abnormal_hair_follicle1.65741766
52MP0001986_abnormal_taste_sensitivity1.60352885
53MP0000490_abnormal_crypts_of1.58142678
54MP0009785_altered_susceptibility_to1.56464406
55MP0003693_abnormal_embryo_hatching1.54778427
56MP0002972_abnormal_cardiac_muscle1.53935691
57MP0001661_extended_life_span1.50986472
58MP0009697_abnormal_copulation1.48401056
59MP0000015_abnormal_ear_pigmentation1.46239151
60MP0005379_endocrine/exocrine_gland_phen1.46128269
61MP0000465_gastrointestinal_hemorrhage1.43954056
62MP0005275_abnormal_skin_tensile1.43677712
63* MP0002106_abnormal_muscle_physiology1.43237285
64MP0001853_heart_inflammation1.38864993
65MP0001958_emphysema1.36945658
66MP0002009_preneoplasia1.35988033
67MP0000751_myopathy1.34821784
68MP0004510_myositis1.34565581
69MP0008007_abnormal_cellular_replicative1.34344692
70MP0002177_abnormal_outer_ear1.34079349
71MP0005623_abnormal_meninges_morphology1.32965887
72MP0000569_abnormal_digit_pigmentation1.32340838
73MP0001119_abnormal_female_reproductive1.31189781
74MP0005595_abnormal_vascular_smooth1.29975476
75MP0000013_abnormal_adipose_tissue1.28864760
76MP0003950_abnormal_plasma_membrane1.28405159
77MP0002006_tumorigenesis1.28309675
78MP0001873_stomach_inflammation1.26028064
79MP0008058_abnormal_DNA_repair1.23378114
80MP0003315_abnormal_perineum_morphology1.22797138
81MP0009333_abnormal_splenocyte_physiolog1.21430632
82MP0004883_abnormal_blood_vessel1.17335222
83MP0005171_absent_coat_pigmentation1.16227087
84* MP0004270_analgesia1.16086495
85MP0005025_abnormal_response_to1.15563478
86MP0002398_abnormal_bone_marrow1.13972526
87MP0003880_abnormal_central_pattern1.13596590
88MP0002933_joint_inflammation1.12610085
89MP0006054_spinal_hemorrhage1.12580288
90MP0002148_abnormal_hypersensitivity_rea1.12075140
91MP0000689_abnormal_spleen_morphology1.10254183
92MP0010630_abnormal_cardiac_muscle1.10003897
93MP0002166_altered_tumor_susceptibility1.09864948
94MP0002932_abnormal_joint_morphology1.07704167
95MP0001800_abnormal_humoral_immune1.06535572
96MP0001545_abnormal_hematopoietic_system1.05309142
97MP0005397_hematopoietic_system_phenotyp1.05309142
98* MP0005369_muscle_phenotype1.03594297
99MP0002723_abnormal_immune_serum1.03067936
100MP0005464_abnormal_platelet_physiology1.01277836
101MP0002420_abnormal_adaptive_immunity1.00696306
102MP0002938_white_spotting0.99723741
103MP0001819_abnormal_immune_cell0.98924911
104MP0003011_delayed_dark_adaptation0.98535988
105MP0002452_abnormal_antigen_presenting0.96486459
106MP0001905_abnormal_dopamine_level0.96387208
107MP0009250_abnormal_appendicular_skeleto0.95592069
108MP0003866_abnormal_defecation0.94091073
109MP0010094_abnormal_chromosome_stability0.92995422
110MP0002210_abnormal_sex_determination0.92588320
111* MP0000759_abnormal_skeletal_muscle0.92330127
112MP0003137_abnormal_impulse_conducting0.91817350
113MP0002089_abnormal_postnatal_growth/wei0.91557773
114MP0003656_abnormal_erythrocyte_physiolo0.91274412
115MP0000681_abnormal_thyroid_gland0.90472076
116MP0003943_abnormal_hepatobiliary_system0.89401906
117MP0003786_premature_aging0.89254017
118MP0005647_abnormal_sex_gland0.88257953
119MP0002168_other_aberrant_phenotype0.87894767
120MP0005000_abnormal_immune_tolerance0.87218555
121MP0005164_abnormal_response_to0.86930883
122MP0005023_abnormal_wound_healing0.86836463
123MP0003699_abnormal_female_reproductive0.85677435
124* MP0004145_abnormal_muscle_electrophysio0.85430501
125MP0003806_abnormal_nucleotide_metabolis0.84302533
126MP0000716_abnormal_immune_system0.83680858
127MP0000762_abnormal_tongue_morphology0.83377576
128MP0010030_abnormal_orbit_morphology0.82768176
129MP0002722_abnormal_immune_system0.82627221
130MP0005408_hypopigmentation0.82337653
131MP0000767_abnormal_smooth_muscle0.82178762
132MP0000049_abnormal_middle_ear0.82144819
133MP0002127_abnormal_cardiovascular_syste0.82007300
134MP0001851_eye_inflammation0.81511242
135MP0001929_abnormal_gametogenesis0.79839035
136MP0002295_abnormal_pulmonary_circulatio0.79657423
137MP0000653_abnormal_sex_gland0.78813499
138MP0003091_abnormal_cell_migration0.78350590
139MP0001663_abnormal_digestive_system0.78205558
140MP0008995_early_reproductive_senescence0.77752032
141MP0002896_abnormal_bone_mineralization0.77288112
142MP0002876_abnormal_thyroid_physiology0.76694514
143MP0002405_respiratory_system_inflammati0.76632595
144MP0005385_cardiovascular_system_phenoty0.75787847
145MP0001544_abnormal_cardiovascular_syste0.75787847
146MP0002877_abnormal_melanocyte_morpholog0.75685387
147MP0005646_abnormal_pituitary_gland0.74847603
148MP0003077_abnormal_cell_cycle0.74448564
149MP0002419_abnormal_innate_immunity0.74362207
150MP0003828_pulmonary_edema0.74024147
151MP0002429_abnormal_blood_cell0.73978757
152MP0005367_renal/urinary_system_phenotyp0.73181380
153MP0000516_abnormal_urinary_system0.73181380
154MP0002282_abnormal_trachea_morphology0.70517240
155MP0008775_abnormal_heart_ventricle0.69425952
156MP0001485_abnormal_pinna_reflex0.69089842
157MP0005503_abnormal_tendon_morphology0.68939136
158MP0004484_altered_response_of0.68326798
159MP0002332_abnormal_exercise_endurance0.68036573
160MP0009384_cardiac_valve_regurgitation0.67742700
161MP0000230_abnormal_systemic_arterial0.65187462
162* MP0002114_abnormal_axial_skeleton0.64694907
163MP0003959_abnormal_lean_body0.63122785
164MP0003221_abnormal_cardiomyocyte_apopto0.60820561
165MP0000003_abnormal_adipose_tissue0.60677417
166MP0002133_abnormal_respiratory_system0.60538174
167MP0005388_respiratory_system_phenotype0.60538174
168MP0008789_abnormal_olfactory_epithelium0.59065410
169MP0000538_abnormal_urinary_bladder0.58503143
170MP0009053_abnormal_anal_canal0.58030407
171MP0005253_abnormal_eye_physiology0.55911780
172MP0005508_abnormal_skeleton_morphology0.52168607
173MP0003566_abnormal_cell_adhesion0.50187947
174MP0005165_increased_susceptibility_to0.49147287
175MP0010352_gastrointestinal_tract_polyps0.46219235
176MP0002128_abnormal_blood_circulation0.45678274
177MP0003385_abnormal_body_wall0.45646715
178MP0005395_other_phenotype0.45306681
179MP0000534_abnormal_ureter_morphology0.44561014
180MP0001849_ear_inflammation0.43925141
181MP0006138_congestive_heart_failure0.43331626
182MP0003755_abnormal_palate_morphology0.42718395

Predicted human phenotypes

RankGene SetZ-score
1* Type 2 muscle fiber atrophy (HP:0003554)5.32578032
2Pterygium (HP:0001059)5.25452631
3Amniotic constriction ring (HP:0009775)5.22661706
4Abnormality of placental membranes (HP:0011409)5.22661706
5* Nonprogressive disorder (HP:0003680)5.17741321
6Thin ribs (HP:0000883)4.70506055
7* Muscle fiber atrophy (HP:0100295)4.65963439
8Akinesia (HP:0002304)4.56950948
9Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.40715945
10Muscle fiber inclusion bodies (HP:0100299)4.31751412
11Aortic aneurysm (HP:0004942)4.10123562
12Aortic dissection (HP:0002647)3.95783820
13Fetal akinesia sequence (HP:0001989)3.90843160
14Nemaline bodies (HP:0003798)3.88922833
15Popliteal pterygium (HP:0009756)3.88151807
16Type I transferrin isoform profile (HP:0003642)3.87998550
17Long clavicles (HP:0000890)3.86519934
18Sudden death (HP:0001699)3.76730174
19Abnormal number of erythroid precursors (HP:0012131)3.71443454
20Exercise-induced myalgia (HP:0003738)3.68164313
21Abnormality of cells of the erythroid lineage (HP:0012130)3.66391259
22* Weak cry (HP:0001612)3.58733265
23Absent phalangeal crease (HP:0006109)3.56288690
24Hypoplastic ischia (HP:0003175)3.51123945
25Reduced antithrombin III activity (HP:0001976)3.50507799
26Distal arthrogryposis (HP:0005684)3.41294154
27Malignant hyperthermia (HP:0002047)3.35797896
28Hyporeflexia of lower limbs (HP:0002600)3.32302368
29Aplastic anemia (HP:0001915)3.22914546
30Aplasia of the musculature (HP:0100854)3.21724365
31* Abnormality of the neuromuscular junction (HP:0003398)3.19344077
32* Fatigable weakness (HP:0003473)3.19344077
33Abnormality of the ischium (HP:0003174)3.11898446
34Bell-shaped thorax (HP:0001591)3.02751910
35Abnormality of secondary sexual hair (HP:0009888)2.99791748
36Abnormality of the axillary hair (HP:0100134)2.99791748
37Arterial tortuosity (HP:0005116)2.99752958
38Wrist flexion contracture (HP:0001239)2.96150058
39Abnormal finger flexion creases (HP:0006143)2.91304160
40Neck muscle weakness (HP:0000467)2.89567300
41Exercise-induced muscle cramps (HP:0003710)2.86291427
42Vascular tortuosity (HP:0004948)2.84322667
43Bulbar palsy (HP:0001283)2.84285888
44Asymmetric septal hypertrophy (HP:0001670)2.77634184
45* Respiratory insufficiency due to muscle weakness (HP:0002747)2.76022353
46Thrombocytosis (HP:0001894)2.68412102
47Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.68368831
48Abnormal protein N-linked glycosylation (HP:0012347)2.68368831
49Abnormal protein glycosylation (HP:0012346)2.68368831
50Abnormal glycosylation (HP:0012345)2.68368831
51Mesomelia (HP:0003027)2.65462187
52Abnormality of the heme biosynthetic pathway (HP:0010472)2.60120717
53* Easy fatigability (HP:0003388)2.57546953
54Hypothermia (HP:0002045)2.51552401
553-Methylglutaconic aciduria (HP:0003535)2.50009789
56Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.49326410
57Abnormality of the columella (HP:0009929)2.49226393
58Myositis (HP:0100614)2.47700233
59True hermaphroditism (HP:0010459)2.47090345
60Lipoatrophy (HP:0100578)2.45019147
61Prolonged bleeding time (HP:0003010)2.43005377
62Absent rod-and cone-mediated responses on ERG (HP:0007688)2.42221211
63Acute myeloid leukemia (HP:0004808)2.42005056
64Calf muscle hypertrophy (HP:0008981)2.41697316
65Muscle hypertrophy of the lower extremities (HP:0008968)2.35040947
66Cerebral aneurysm (HP:0004944)2.34922146
67Diminished movement (HP:0002374)2.34042331
68Depressed nasal tip (HP:0000437)2.33024162
69Type 1 muscle fiber predominance (HP:0003803)2.32991893
70Microglossia (HP:0000171)2.31669784
71Calcaneovalgus deformity (HP:0001848)2.31153371
72Chromosomal breakage induced by crosslinking agents (HP:0003221)2.30585993
73Protrusio acetabuli (HP:0003179)2.29886724
74Chromsome breakage (HP:0040012)2.27749985
75Fibular aplasia (HP:0002990)2.25078202
76Increased hepatocellular lipid droplets (HP:0006565)2.24131839
77Parakeratosis (HP:0001036)2.24074783
78Short palpebral fissure (HP:0012745)2.23563517
79Hypoplasia of the iris (HP:0007676)2.21723032
80Prostate neoplasm (HP:0100787)2.20529698
81Deformed tarsal bones (HP:0008119)2.17988320
82Aplasia/Hypoplasia involving the musculature (HP:0001460)2.17214357
83Exertional dyspnea (HP:0002875)2.16963342
84Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.16294018
85Abnormality of the prostate (HP:0008775)2.14813744
86Spondylolisthesis (HP:0003302)2.12387857
87Hypergonadotropic hypogonadism (HP:0000815)2.12062028
88Abnormal pupillary function (HP:0007686)2.11732413
89Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.11148695
90Petechiae (HP:0000967)2.10839160
91Abnormality of the calf musculature (HP:0001430)2.09982277
92Premature rupture of membranes (HP:0001788)2.09902088
93Reticulocytopenia (HP:0001896)2.08899663
94Renal Fanconi syndrome (HP:0001994)2.08580152
95Pancreatic fibrosis (HP:0100732)2.07484287
96Hypoplastic heart (HP:0001961)2.04994354
97Increased intramyocellular lipid droplets (HP:0012240)2.01604899
98Optic neuritis (HP:0100653)2.01462381
99Retrobulbar optic neuritis (HP:0100654)2.01462381
100Ulnar deviation of the wrist (HP:0003049)1.99861123
101Abnormality of the umbilical cord (HP:0010881)1.99132719
102Hepatocellular necrosis (HP:0001404)1.98695815
103* Arthrogryposis multiplex congenita (HP:0002804)1.96555521
104Abnormalities of placenta or umbilical cord (HP:0001194)1.95200691
105Patchy hypopigmentation of hair (HP:0011365)1.95066055
106Distal lower limb muscle weakness (HP:0009053)1.94221290
107Decreased activity of mitochondrial respiratory chain (HP:0008972)1.92932193
108Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.92932193
109IgM deficiency (HP:0002850)1.92658024
110Progressive inability to walk (HP:0002505)1.90785546
111Respiratory difficulties (HP:0002880)1.90099355
112Hyperlipoproteinemia (HP:0010980)1.88897956
113Severe visual impairment (HP:0001141)1.88289012
114Short thorax (HP:0010306)1.87183670
115Generalized muscle weakness (HP:0003324)1.85533512
116Left ventricular hypertrophy (HP:0001712)1.85010162
117Delayed gross motor development (HP:0002194)1.84268640
118Orchitis (HP:0100796)1.84105947
119Limited hip movement (HP:0008800)1.83479424
120Stillbirth (HP:0003826)1.82762487
121Adrenal hypoplasia (HP:0000835)1.81617600
122Myelodysplasia (HP:0002863)1.81594861
123Lipid accumulation in hepatocytes (HP:0006561)1.79090417
124Supernumerary spleens (HP:0009799)1.77250434
125Elevated erythrocyte sedimentation rate (HP:0003565)1.76470277
126Myopathic facies (HP:0002058)1.75742859
127Hip contracture (HP:0003273)1.75054585
128Birth length less than 3rd percentile (HP:0003561)1.74218043
129Clubbing of toes (HP:0100760)1.72949383
130Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.72296933
131* Decreased muscle mass (HP:0003199)1.71622999
132Hypoplastic iliac wings (HP:0002866)1.71573635
133Pallor (HP:0000980)1.70152293
134Ventricular arrhythmia (HP:0004308)1.68780133
135Abnormality of the left ventricular outflow tract (HP:0011103)1.68408336
136Subaortic stenosis (HP:0001682)1.68408336
137Absent septum pellucidum (HP:0001331)1.68392725
138Congenital, generalized hypertrichosis (HP:0004540)1.68152341
139* Gowers sign (HP:0003391)1.67058990
140Abnormal rod and cone electroretinograms (HP:0008323)1.66143574
141Scapular winging (HP:0003691)1.65971239
142Epistaxis (HP:0000421)1.65581969
143Round ear (HP:0100830)1.63662332
144Mediastinal lymphadenopathy (HP:0100721)1.62328943
145Poor suck (HP:0002033)1.61975774
146Keratoconus (HP:0000563)1.61615322
147Increased corneal curvature (HP:0100692)1.61615322
148Thyroid-stimulating hormone excess (HP:0002925)1.61179322
149Cystic hygroma (HP:0000476)1.60865121
150Meningitis (HP:0001287)1.59880224
151Abnormal platelet function (HP:0011869)1.59344856
152Myotonia (HP:0002486)1.58975050
153Slender long bone (HP:0003100)1.58817469
154Soft skin (HP:0000977)1.57727503
155Limb-girdle muscle atrophy (HP:0003797)1.56003556
156Generalized amyotrophy (HP:0003700)1.54102397
157Vertebral fusion (HP:0002948)1.51542726
158EMG: myopathic abnormalities (HP:0003458)1.50775292
159Mitral stenosis (HP:0001718)1.50527197
160Webbed neck (HP:0000465)1.49957513
161Pulmonary hypoplasia (HP:0002089)1.49522959
162Dyschromatopsia (HP:0007641)1.49098815
163Atrial fibrillation (HP:0005110)1.48878499
164Dilatation of the ascending aorta (HP:0005111)1.48700898

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK24.44977506
2TNIK4.16474332
3LIMK14.14898032
4MKNK13.38283466
5MOS3.22717822
6MAPKAPK52.42113042
7STK162.40573867
8FRK2.38487494
9NME22.32268607
10TESK22.22037300
11KIT2.18756751
12SRPK12.12227921
13OBSCN2.00318096
14MAP3K61.97952432
15NLK1.94586395
16CASK1.91105436
17MAP3K121.91070301
18PLK41.89989101
19NEK11.83275797
20MAPKAPK31.76254261
21MELK1.75329027
22CDK81.73939947
23CDK191.72878674
24EEF2K1.69856346
25RAF11.69542732
26TEC1.62860728
27PIM21.62590725
28TAF11.59367753
29CAMKK21.50871986
30ERBB41.47721127
31PIK3CG1.44435223
32VRK11.43696505
33TXK1.39658441
34ACVR1B1.32663706
35MAP4K21.30389937
36MAP2K71.29668447
37TIE11.28084039
38TAOK31.24170869
39DDR21.23106933
40IKBKB1.22678751
41NEK61.21833770
42ILK1.20699002
43* MUSK1.20016706
44PRKD31.19014403
45TGFBR11.18441213
46CSNK1G11.17613499
47PAK41.17234961
48PINK11.16675224
49CDK31.15234351
50PLK21.13993571
51VRK21.13786739
52PRKG21.13044995
53IRAK41.12037165
54ROCK11.12004260
55MAP3K131.11978017
56WEE11.10976614
57TGFBR21.08654269
58PBK1.08418599
59FER1.07654851
60MAPK131.06300213
61STK391.03929542
62BMPR1B1.02990946
63BTK1.01371803
64IKBKE0.99754429
65PIM10.99373034
66BRAF0.98191792
67EIF2AK30.98104622
68MAP4K10.97598591
69PRKD20.97468812
70MAP3K50.97353656
71CDK90.96065900
72DMPK0.95527570
73DAPK30.94218260
74CAMK2D0.93513724
75EPHA30.93483862
76PAK60.92327794
77ROCK20.91905457
78TRPM70.91287342
79CAMK10.90823201
80DYRK30.85768723
81IRAK30.82849413
82HIPK20.82045340
83RPS6KB20.79856670
84ADRBK20.79629872
85EIF2AK20.78930446
86FGFR20.78748933
87BRSK20.77524084
88PAK20.77518227
89MAP3K100.77370392
90RIPK10.75797225
91CSNK1G30.69249641
92JAK30.68361556
93FLT30.68297743
94SIK30.67548857
95MAP2K10.67486997
96AKT20.65385505
97DYRK20.64413538
98TNK20.63932620
99MINK10.62754896
100ARAF0.62634372
101MARK20.62409903
102PAK30.61645713
103TRIM280.61604423
104GRK10.60946945
105JAK10.59444149
106LATS10.58962993
107LMTK20.57456151
108PRKAA20.56585449
109IRAK10.56438394
110MAPK120.56115593
111MAP3K30.55535649
112PTK20.55174416
113CSF1R0.54706739
114LYN0.54424577
115MAPK40.53086670
116PRKCE0.52299573
117CDK70.52100794
118TYK20.51589859
119GRK70.50389684
120SYK0.49283779
121TBK10.46617578
122KDR0.46499113
123MATK0.45925857
124PRKACB0.43461521
125PTK2B0.43430572
126RPS6KA50.43240645
127CAMK2B0.42691881
128MET0.42573885
129MAP2K30.42100754
130MAP2K60.41621440
131BRD40.41049066
132STK240.40257569
133STK30.40159203
134FGFR40.40096598
135ABL10.39915419
136NEK90.39874223
137YES10.39490137
138PIK3CA0.38814093
139MYLK0.37994722
140CDC42BPA0.36936829
141CCNB10.36796845
142AURKB0.36516658
143CSNK1G20.36362343
144CAMK2G0.35751641
145FES0.34128380
146PHKG10.33790619
147PHKG20.33790619
148MAP3K70.33124709
149PDGFRA0.31635643
150BCKDK0.31441590
151CHUK0.31211969
152PDGFRB0.29746833
153PRKD10.29714753
154ABL20.28677459
155NUAK10.28390437
156SGK20.28091038
157IGF1R0.27172448
158LCK0.26456556
159PLK30.26280830
160INSR0.25725919
161ERBB30.25153686
162TTN0.24939135
163MARK30.24560997
164STK38L0.23337001
165OXSR10.22978978
166MAPK70.22244011
167AKT30.22102218
168SGK30.21767803
169GSK3A0.21740170
170CAMK2A0.20940854
171EGFR0.19564292

Predicted pathways (KEGG)

RankGene SetZ-score
1Dilated cardiomyopathy_Homo sapiens_hsa054144.74265863
2Ribosome_Homo sapiens_hsa030103.71536244
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.59203547
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.56140721
5DNA replication_Homo sapiens_hsa030302.97153393
6Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.60132418
7Selenocompound metabolism_Homo sapiens_hsa004502.56770034
8Focal adhesion_Homo sapiens_hsa045102.56162563
9RNA polymerase_Homo sapiens_hsa030202.55155789
10Homologous recombination_Homo sapiens_hsa034402.52439784
11RNA degradation_Homo sapiens_hsa030182.51733097
12Cardiac muscle contraction_Homo sapiens_hsa042602.36441128
13Base excision repair_Homo sapiens_hsa034102.26643875
14ECM-receptor interaction_Homo sapiens_hsa045122.26465653
15Basal transcription factors_Homo sapiens_hsa030222.22156101
16Protein export_Homo sapiens_hsa030602.21843974
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.18339393
18Mineral absorption_Homo sapiens_hsa049782.13136089
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.05935492
20Sulfur metabolism_Homo sapiens_hsa009201.93952449
21Pyrimidine metabolism_Homo sapiens_hsa002401.91235539
22Mismatch repair_Homo sapiens_hsa034301.87811340
23Fanconi anemia pathway_Homo sapiens_hsa034601.87769507
24Tight junction_Homo sapiens_hsa045301.87647455
25Nucleotide excision repair_Homo sapiens_hsa034201.76674298
26Cell cycle_Homo sapiens_hsa041101.76369073
27Viral myocarditis_Homo sapiens_hsa054161.75694340
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.75524558
29Proteoglycans in cancer_Homo sapiens_hsa052051.69523232
30Adherens junction_Homo sapiens_hsa045201.68749152
31Ovarian steroidogenesis_Homo sapiens_hsa049131.64735234
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.64433299
33Non-homologous end-joining_Homo sapiens_hsa034501.64242693
34Purine metabolism_Homo sapiens_hsa002301.59569358
35Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.56696768
36Transcriptional misregulation in cancer_Homo sapiens_hsa052021.45606277
37Circadian rhythm_Homo sapiens_hsa047101.44590073
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.42835178
39Regulation of actin cytoskeleton_Homo sapiens_hsa048101.42777991
40One carbon pool by folate_Homo sapiens_hsa006701.40598293
41Primary immunodeficiency_Homo sapiens_hsa053401.40018545
42Dorso-ventral axis formation_Homo sapiens_hsa043201.39525813
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.38803162
44Vascular smooth muscle contraction_Homo sapiens_hsa042701.32687597
45p53 signaling pathway_Homo sapiens_hsa041151.28206063
46Propanoate metabolism_Homo sapiens_hsa006401.26813485
47Galactose metabolism_Homo sapiens_hsa000521.23191239
48Hippo signaling pathway_Homo sapiens_hsa043901.22919133
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.22550896
50Spliceosome_Homo sapiens_hsa030401.22225502
51Arachidonic acid metabolism_Homo sapiens_hsa005901.18999778
52NF-kappa B signaling pathway_Homo sapiens_hsa040641.18907485
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17324431
54Histidine metabolism_Homo sapiens_hsa003401.14282001
55Hematopoietic cell lineage_Homo sapiens_hsa046401.13774149
56Protein digestion and absorption_Homo sapiens_hsa049741.13762956
57Melanoma_Homo sapiens_hsa052181.11583938
58Jak-STAT signaling pathway_Homo sapiens_hsa046301.11314654
59Malaria_Homo sapiens_hsa051441.11166177
60Other glycan degradation_Homo sapiens_hsa005111.09267324
61Herpes simplex infection_Homo sapiens_hsa051681.08907170
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.06626745
63Arginine and proline metabolism_Homo sapiens_hsa003301.05963605
64Proteasome_Homo sapiens_hsa030501.04670357
65Tryptophan metabolism_Homo sapiens_hsa003801.04641151
66Sphingolipid metabolism_Homo sapiens_hsa006001.03208128
67Caffeine metabolism_Homo sapiens_hsa002321.01475863
68SNARE interactions in vesicular transport_Homo sapiens_hsa041301.01174681
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.00694393
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00506374
71Hedgehog signaling pathway_Homo sapiens_hsa043400.99554812
72Ether lipid metabolism_Homo sapiens_hsa005650.98195638
73Vitamin digestion and absorption_Homo sapiens_hsa049770.97875065
74N-Glycan biosynthesis_Homo sapiens_hsa005100.97210931
75Linoleic acid metabolism_Homo sapiens_hsa005910.95667825
76Platelet activation_Homo sapiens_hsa046110.94236701
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91998980
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91870233
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89618820
80Allograft rejection_Homo sapiens_hsa053300.88455867
81Measles_Homo sapiens_hsa051620.87193226
82Acute myeloid leukemia_Homo sapiens_hsa052210.84301944
83Amoebiasis_Homo sapiens_hsa051460.82853086
84Small cell lung cancer_Homo sapiens_hsa052220.80797748
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79720775
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.79662070
87Salivary secretion_Homo sapiens_hsa049700.79020184
88B cell receptor signaling pathway_Homo sapiens_hsa046620.79012058
89Complement and coagulation cascades_Homo sapiens_hsa046100.77785516
90Renin secretion_Homo sapiens_hsa049240.77395999
91Fatty acid degradation_Homo sapiens_hsa000710.74694217
92ABC transporters_Homo sapiens_hsa020100.73943790
93Pyruvate metabolism_Homo sapiens_hsa006200.73922271
94Taste transduction_Homo sapiens_hsa047420.72516776
95Folate biosynthesis_Homo sapiens_hsa007900.70794271
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69631326
97Oxytocin signaling pathway_Homo sapiens_hsa049210.69529724
98Gap junction_Homo sapiens_hsa045400.68755943
99RNA transport_Homo sapiens_hsa030130.67561224
100Notch signaling pathway_Homo sapiens_hsa043300.65721549
101Glucagon signaling pathway_Homo sapiens_hsa049220.64307045
102Hepatitis B_Homo sapiens_hsa051610.63578389
103Fat digestion and absorption_Homo sapiens_hsa049750.61392225
104Lysine degradation_Homo sapiens_hsa003100.58986102
105beta-Alanine metabolism_Homo sapiens_hsa004100.58976506
106Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58259031
107Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58214266
108NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57955709
109Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.57730401
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57327325
111Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57147425
112Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55701931
113Leishmaniasis_Homo sapiens_hsa051400.54731918
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54551470
115Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54468251
116Thyroid cancer_Homo sapiens_hsa052160.54437155
117Asthma_Homo sapiens_hsa053100.53310020
118Sulfur relay system_Homo sapiens_hsa041220.53274139
119Glycerolipid metabolism_Homo sapiens_hsa005610.50996328
120Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50618077
121Retinol metabolism_Homo sapiens_hsa008300.50340770
122Steroid hormone biosynthesis_Homo sapiens_hsa001400.49929022
123Serotonergic synapse_Homo sapiens_hsa047260.49710319
124PPAR signaling pathway_Homo sapiens_hsa033200.49572778
125Huntingtons disease_Homo sapiens_hsa050160.49338492
126TGF-beta signaling pathway_Homo sapiens_hsa043500.49165051
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49053156
128Basal cell carcinoma_Homo sapiens_hsa052170.48496337
129Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48277117
130Wnt signaling pathway_Homo sapiens_hsa043100.47608051
131Leukocyte transendothelial migration_Homo sapiens_hsa046700.47451246
132Parkinsons disease_Homo sapiens_hsa050120.46318064
133Starch and sucrose metabolism_Homo sapiens_hsa005000.45118933
134Long-term depression_Homo sapiens_hsa047300.45031795
135AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44615551
136Autoimmune thyroid disease_Homo sapiens_hsa053200.44409285
137Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43377219
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43246784
139Endocytosis_Homo sapiens_hsa041440.42941162
140Prolactin signaling pathway_Homo sapiens_hsa049170.42886143
141Epstein-Barr virus infection_Homo sapiens_hsa051690.39719668
142Influenza A_Homo sapiens_hsa051640.38849236
143Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37625246
144Oxidative phosphorylation_Homo sapiens_hsa001900.37300684
145Shigellosis_Homo sapiens_hsa051310.36614083
146MicroRNAs in cancer_Homo sapiens_hsa052060.35913579
147Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35598241
148Antigen processing and presentation_Homo sapiens_hsa046120.35292535
149Apoptosis_Homo sapiens_hsa042100.34630309
150Pancreatic secretion_Homo sapiens_hsa049720.33909612
151Graft-versus-host disease_Homo sapiens_hsa053320.32683843
152Pancreatic cancer_Homo sapiens_hsa052120.32650557
153FoxO signaling pathway_Homo sapiens_hsa040680.31709917
154Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.31311727
155African trypanosomiasis_Homo sapiens_hsa051430.31165330
156HTLV-I infection_Homo sapiens_hsa051660.31137321
157Butanoate metabolism_Homo sapiens_hsa006500.30672393
158Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29784125
159Calcium signaling pathway_Homo sapiens_hsa040200.29137020
160Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.27866380
161Phototransduction_Homo sapiens_hsa047440.27722779
162Primary bile acid biosynthesis_Homo sapiens_hsa001200.27544910
163Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27501256
164Olfactory transduction_Homo sapiens_hsa047400.27267559
165Pathways in cancer_Homo sapiens_hsa052000.27262154
166Fatty acid elongation_Homo sapiens_hsa000620.27261312
167GnRH signaling pathway_Homo sapiens_hsa049120.27133888
168Alzheimers disease_Homo sapiens_hsa050100.27127763
169Salmonella infection_Homo sapiens_hsa051320.27040736
170Chemical carcinogenesis_Homo sapiens_hsa052040.26788350
171TNF signaling pathway_Homo sapiens_hsa046680.26710778
172Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26318515
173Cyanoamino acid metabolism_Homo sapiens_hsa004600.25271080
174Insulin resistance_Homo sapiens_hsa049310.24204615

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