MUM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)7.49504933
2cilium or flagellum-dependent cell motility (GO:0001539)6.83603541
3fusion of sperm to egg plasma membrane (GO:0007342)6.25861122
4DNA double-strand break processing (GO:0000729)6.23796699
5DNA methylation involved in gamete generation (GO:0043046)5.79634604
6male meiosis (GO:0007140)5.77771071
7axonemal dynein complex assembly (GO:0070286)5.68674412
8sperm motility (GO:0030317)5.62146805
9regulation of mitochondrial translation (GO:0070129)5.50115666
10synaptonemal complex organization (GO:0070193)5.43746894
11synaptonemal complex assembly (GO:0007130)5.43566245
12sperm-egg recognition (GO:0035036)5.36717648
13binding of sperm to zona pellucida (GO:0007339)5.20746669
14postsynaptic membrane organization (GO:0001941)5.19833560
15motile cilium assembly (GO:0044458)5.15388032
16acrosome assembly (GO:0001675)5.08596774
17acrosome reaction (GO:0007340)4.96732024
18epithelial cilium movement (GO:0003351)4.83097372
19cell-cell recognition (GO:0009988)4.80949428
20multicellular organism reproduction (GO:0032504)4.80102697
21spermatid development (GO:0007286)4.74883214
22regulation of short-term neuronal synaptic plasticity (GO:0048172)4.70974776
23male meiosis I (GO:0007141)4.67425135
24plasma membrane fusion (GO:0045026)4.60269431
25regulation of histone H3-K27 methylation (GO:0061085)4.52105858
26chromosome organization involved in meiosis (GO:0070192)4.51213834
27regulation of oxidative phosphorylation (GO:0002082)4.48535603
28translesion synthesis (GO:0019985)4.48014987
29meiotic nuclear division (GO:0007126)4.26692719
30synaptic vesicle docking involved in exocytosis (GO:0016081)4.25818421
31cilium movement (GO:0003341)4.22283583
32presynaptic membrane assembly (GO:0097105)4.16768599
33epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.16628261
34positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.11701710
35vocalization behavior (GO:0071625)4.06559178
36DNA catabolic process, exonucleolytic (GO:0000738)4.05409603
37meiotic cell cycle (GO:0051321)4.05337909
38neuron cell-cell adhesion (GO:0007158)4.04181270
39formation of translation preinitiation complex (GO:0001731)4.03627742
40presynaptic membrane organization (GO:0097090)4.01614220
41synaptic vesicle maturation (GO:0016188)3.93222123
42meiosis I (GO:0007127)3.92237466
43cell wall macromolecule catabolic process (GO:0016998)3.86301125
44cell wall macromolecule metabolic process (GO:0044036)3.86301125
45postreplication repair (GO:0006301)3.85359184
46regulation of meiosis I (GO:0060631)3.77887539
47regulation of histone H3-K9 methylation (GO:0051570)3.74879512
48glutamate secretion (GO:0014047)3.74281715
49reproduction (GO:0000003)3.71630784
50DNA strand elongation involved in DNA replication (GO:0006271)3.70573245
51protein localization to synapse (GO:0035418)3.68048328
52regulation of skeletal muscle cell differentiation (GO:2001014)3.66272245
53microtubule depolymerization (GO:0007019)3.66068695
54pyrimidine nucleobase catabolic process (GO:0006208)3.65521352
55intra-S DNA damage checkpoint (GO:0031573)3.63040005
56membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.59645275
57regulation of cilium movement (GO:0003352)3.56359375
58DNA synthesis involved in DNA repair (GO:0000731)3.53899320
59DNA replication-dependent nucleosome assembly (GO:0006335)3.51785573
60DNA replication-dependent nucleosome organization (GO:0034723)3.51785573
61DNA strand elongation (GO:0022616)3.50051697
62maturation of SSU-rRNA (GO:0030490)3.49634179
63histone exchange (GO:0043486)3.46090936
64single fertilization (GO:0007338)3.45945518
65gamma-aminobutyric acid transport (GO:0015812)3.45654970
66ionotropic glutamate receptor signaling pathway (GO:0035235)3.43656120
67spermatogenesis (GO:0007283)3.43296273
68telomere maintenance via semi-conservative replication (GO:0032201)3.43164198
69regulation of centriole replication (GO:0046599)3.42841589
70synaptic vesicle exocytosis (GO:0016079)3.42832643
71centriole replication (GO:0007099)3.42756082
72male gamete generation (GO:0048232)3.42693227
73DNA replication initiation (GO:0006270)3.41080776
74centriole assembly (GO:0098534)3.40695839
75cellular response to interleukin-15 (GO:0071350)3.40378003
76cellular copper ion homeostasis (GO:0006878)3.37404006
77establishment of mitochondrion localization (GO:0051654)3.37182766
78central nervous system myelination (GO:0022010)3.36911407
79axon ensheathment in central nervous system (GO:0032291)3.36911407
80dendritic spine morphogenesis (GO:0060997)3.36750071
81cell migration in hindbrain (GO:0021535)3.35023463
82synapsis (GO:0007129)3.34047923
83DNA methylation (GO:0006306)3.33543287
84DNA alkylation (GO:0006305)3.33543287
85DNA replication checkpoint (GO:0000076)3.31876898
86negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.31669399
87regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.31622836
88auditory behavior (GO:0031223)3.31187124
89single strand break repair (GO:0000012)3.29886227
90locomotory exploration behavior (GO:0035641)3.29031252
91neuronal action potential propagation (GO:0019227)3.27827856
92fertilization (GO:0009566)3.27200707
93regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.25550586
94neurotransmitter-gated ion channel clustering (GO:0072578)3.25435448
95neurotransmitter secretion (GO:0007269)3.25263049
96germ cell development (GO:0007281)3.20127601
97synaptic transmission, glutamatergic (GO:0035249)3.20110089
98transmission of nerve impulse (GO:0019226)3.17756287
99gamete generation (GO:0007276)3.16197768
100positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.15677099
101regulation of synaptic vesicle exocytosis (GO:2000300)3.13313056
102monoubiquitinated protein deubiquitination (GO:0035520)3.13258808
103neuronal ion channel clustering (GO:0045161)3.12534863
104regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.10521755
105negative regulation of synaptic transmission, GABAergic (GO:0032229)3.08268106
106negative regulation of mRNA processing (GO:0050686)3.05819859
107mechanosensory behavior (GO:0007638)3.05486131
108ventricular system development (GO:0021591)3.04907630
109ATP-dependent chromatin remodeling (GO:0043044)3.03490345
110DNA damage induced protein phosphorylation (GO:0006975)3.02403765
111nucleobase catabolic process (GO:0046113)3.02042936
112axonal fasciculation (GO:0007413)3.00778864
113meiotic cell cycle process (GO:1903046)3.00147666
114telomere maintenance via recombination (GO:0000722)2.99475802
115chromatin remodeling at centromere (GO:0031055)2.99305019
116neuron recognition (GO:0008038)2.97885519
117positive regulation of synapse maturation (GO:0090129)2.96985388
118microtubule severing (GO:0051013)2.96339507
119somatic diversification of immune receptors via somatic mutation (GO:0002566)2.94544602
120somatic hypermutation of immunoglobulin genes (GO:0016446)2.94544602
121regulation of respiratory system process (GO:0044065)2.92026600
122regulation of synapse structural plasticity (GO:0051823)2.91971261
123kinetochore organization (GO:0051383)2.91605601
124glutamate receptor signaling pathway (GO:0007215)2.90505114
125positive regulation of histone methylation (GO:0031062)2.90068180
126exploration behavior (GO:0035640)2.86146594
127cellular process involved in reproduction in multicellular organism (GO:0022412)2.85796057
128positive regulation of synapse assembly (GO:0051965)2.83657207
129ribosomal large subunit biogenesis (GO:0042273)2.83554203
130positive regulation of DNA repair (GO:0045739)2.82975282
131gene silencing by RNA (GO:0031047)2.82897222
132positive regulation of dendritic spine development (GO:0060999)2.82470847
133chromosome condensation (GO:0030261)2.81550825
134termination of RNA polymerase II transcription (GO:0006369)2.81055981
135positive regulation of dendritic spine morphogenesis (GO:0061003)2.81018677
136kinetochore assembly (GO:0051382)2.80180462
137DNA packaging (GO:0006323)2.80003171
138histone H4 deacetylation (GO:0070933)2.79626207
139regulation of synaptic vesicle transport (GO:1902803)2.79622182
140CENP-A containing nucleosome assembly (GO:0034080)2.79344022
141cytochrome complex assembly (GO:0017004)2.79071536
142cellular potassium ion homeostasis (GO:0030007)2.78066825
143regulation of neuronal synaptic plasticity (GO:0048168)2.77854631
144nucleotide-excision repair, DNA gap filling (GO:0006297)2.77155066
145mitotic recombination (GO:0006312)2.74545863
146ribosomal small subunit biogenesis (GO:0042274)2.74286547
147short-term memory (GO:0007614)2.74223589
148establishment of integrated proviral latency (GO:0075713)2.74039668
149regulation of glutamate receptor signaling pathway (GO:1900449)2.73712960
150prenylation (GO:0097354)2.72663944
151protein prenylation (GO:0018342)2.72663944
152protein polyglutamylation (GO:0018095)2.72561243
153positive regulation of membrane potential (GO:0045838)2.71415205
154somite development (GO:0061053)2.69725185
155spinal cord development (GO:0021510)2.68631624
156regulation of synapse maturation (GO:0090128)2.68468448
157behavioral response to nicotine (GO:0035095)2.66962826
158C4-dicarboxylate transport (GO:0015740)2.66025659
159limb bud formation (GO:0060174)2.65817609
160mitochondrion transport along microtubule (GO:0047497)2.64238474
161establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.64238474
162synapse assembly (GO:0007416)2.63443599
163neuron-neuron synaptic transmission (GO:0007270)2.62511716
164regulation of neurotransmitter levels (GO:0001505)2.62334532
165regulation of respiratory gaseous exchange (GO:0043576)2.62061373
166neurotransmitter transport (GO:0006836)2.58233812
167neuromuscular synaptic transmission (GO:0007274)2.57746991
168membrane depolarization during action potential (GO:0086010)2.57486635
169sodium ion export (GO:0071436)2.55116254
170central nervous system projection neuron axonogenesis (GO:0021952)2.52359340
171response to auditory stimulus (GO:0010996)2.51662457
172membrane hyperpolarization (GO:0060081)2.51473521
173positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.51321630
174G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.50433701
175regulation of synapse assembly (GO:0051963)2.49490741
176regulation of neurotransmitter uptake (GO:0051580)2.46976847
177regulation of excitatory postsynaptic membrane potential (GO:0060079)2.42993119
178negative regulation of cytosolic calcium ion concentration (GO:0051481)2.42705993
179chemosensory behavior (GO:0007635)2.42468142
180glial cell proliferation (GO:0014009)2.42325425
181nonmotile primary cilium assembly (GO:0035058)2.42032759
182regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.42001613
183cerebellar granule cell differentiation (GO:0021707)2.41620221
184regulation of dendritic spine morphogenesis (GO:0061001)2.39410644
185regulation of postsynaptic membrane potential (GO:0060078)2.38625727
186regulation of neurotransmitter transport (GO:0051588)2.38435125
187regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.36462570
188synapse organization (GO:0050808)2.35327686
189dendritic spine organization (GO:0097061)2.35152320
190regulation of neurotransmitter secretion (GO:0046928)2.35017898
191membrane depolarization (GO:0051899)2.33065970
192regulation of synapse organization (GO:0050807)2.32140046
193glycosphingolipid biosynthetic process (GO:0006688)2.31812418
194adult walking behavior (GO:0007628)2.30270200
195cellular response to cholesterol (GO:0071397)2.30099403
196regulation of dendritic spine development (GO:0060998)2.29128875
197synaptic vesicle endocytosis (GO:0048488)2.29072892
198regulation of long-term neuronal synaptic plasticity (GO:0048169)2.28836308
199negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.28743561
200behavioral defense response (GO:0002209)2.28654821

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.67248172
2* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.62505228
3STAT6_21828071_ChIP-Seq_BEAS2B_Human4.27208503
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.81573183
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.45243087
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.44295309
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.44295309
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.44295309
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.28845822
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.22979543
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.11792730
12EZH2_22144423_ChIP-Seq_EOC_Human3.00216048
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.91659338
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.77982937
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.64638943
16GBX2_23144817_ChIP-Seq_PC3_Human2.64111515
17REST_21632747_ChIP-Seq_MESCs_Mouse2.63267966
18DROSHA_22980978_ChIP-Seq_HELA_Human2.52347137
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.43012146
20JARID2_20064375_ChIP-Seq_MESCs_Mouse2.40169948
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.38651914
22SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.34001821
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.25518702
24ZNF274_21170338_ChIP-Seq_K562_Hela2.24199367
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.21788669
26* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.20001804
27* REST_18959480_ChIP-ChIP_MESCs_Mouse2.16184524
28MYC_18555785_ChIP-Seq_MESCs_Mouse2.16000121
29SUZ12_27294783_Chip-Seq_ESCs_Mouse2.15166884
30EZH2_18974828_ChIP-Seq_MESCs_Mouse2.11057467
31RNF2_18974828_ChIP-Seq_MESCs_Mouse2.11057467
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.08900200
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.08298332
34RNF2_27304074_Chip-Seq_ESCs_Mouse2.07966759
35MYC_19079543_ChIP-ChIP_MESCs_Mouse2.01868898
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.97534191
37SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.95115973
38JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.94943454
39VDR_22108803_ChIP-Seq_LS180_Human1.89244804
40CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.88637824
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.87138251
42ETS1_20019798_ChIP-Seq_JURKAT_Human1.85365364
43SOX2_18555785_ChIP-Seq_MESCs_Mouse1.83414939
44SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.79009387
45MTF2_20144788_ChIP-Seq_MESCs_Mouse1.77859795
46* RARB_27405468_Chip-Seq_BRAIN_Mouse1.74634995
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74232842
48GATA1_26923725_Chip-Seq_HPCs_Mouse1.74160988
49IGF1R_20145208_ChIP-Seq_DFB_Human1.72400919
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.72077633
51MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.68810057
52KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.67802010
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.67685716
54MYC_19030024_ChIP-ChIP_MESCs_Mouse1.65023936
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.64963834
56EST1_17652178_ChIP-ChIP_JURKAT_Human1.63894122
57SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.63361800
58RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.60680602
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.59196642
60GABP_17652178_ChIP-ChIP_JURKAT_Human1.55637204
61PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51840378
62FOXP3_21729870_ChIP-Seq_TREG_Human1.49676164
63ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45926896
64RING1B_27294783_Chip-Seq_ESCs_Mouse1.44479288
65VDR_23849224_ChIP-Seq_CD4+_Human1.43746436
66XRN2_22483619_ChIP-Seq_HELA_Human1.43663684
67* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.43564120
68CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43457363
69* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.42862932
70RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41712067
71SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39804374
72NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.37602946
73ERG_21242973_ChIP-ChIP_JURKAT_Human1.36099427
74RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.34652501
75OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.33032658
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.29751121
77IKZF1_21737484_ChIP-ChIP_HCT116_Human1.29487106
78EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.29037714
79CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.28779379
80HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.28654168
81E2F1_21310950_ChIP-Seq_MCF-7_Human1.25858952
82SALL1_21062744_ChIP-ChIP_HESCs_Human1.25207464
83EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.23895847
84NELFA_20434984_ChIP-Seq_ESCs_Mouse1.23148963
85PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22718096
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21579059
87POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21579059
88HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.21178158
89TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18835875
90SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.16344897
91RING1B_27294783_Chip-Seq_NPCs_Mouse1.15349512
92* CTCF_27219007_Chip-Seq_Bcells_Human1.14013550
93* YY1_22570637_ChIP-Seq_MALME-3M_Human1.13182736
94POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12955733
95AR_19668381_ChIP-Seq_PC3_Human1.09989476
96PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09963840
97SOX2_16153702_ChIP-ChIP_HESCs_Human1.06888937
98CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06041659
99KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05116391
100TTF2_22483619_ChIP-Seq_HELA_Human1.05096236
101BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04843153
102AR_21572438_ChIP-Seq_LNCaP_Human1.04486483
103TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04425338
104YY1_21170310_ChIP-Seq_MESCs_Mouse1.04421868
105SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04271591
106SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03637427
107NANOG_18555785_ChIP-Seq_MESCs_Mouse1.03270065
108FUS_26573619_Chip-Seq_HEK293_Human1.02928493
109CIITA_25753668_ChIP-Seq_RAJI_Human1.01886665
110RNF2_27304074_Chip-Seq_NSC_Mouse1.01809215
111WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00675768
112SMAD3_21741376_ChIP-Seq_ESCs_Human0.99573942
113ZFP281_18757296_ChIP-ChIP_E14_Mouse0.98637283
114CTCF_18555785_ChIP-Seq_MESCs_Mouse0.98010269
115P300_19829295_ChIP-Seq_ESCs_Human0.97265689
116SMAD4_21799915_ChIP-Seq_A2780_Human0.96756862
117GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96452736
118FLI1_27457419_Chip-Seq_LIVER_Mouse0.96028817
119SOX9_26525672_Chip-Seq_HEART_Mouse0.96027467
120PIAS1_25552417_ChIP-Seq_VCAP_Human0.95529736
121PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95328178
122MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95184385
123TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95145772
124WDR5_24793694_ChIP-Seq_LNCAP_Human0.95059092
125THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94872431
126* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94696675
127SOX2_21211035_ChIP-Seq_LN229_Gbm0.94536213
128POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94260376
129GABP_19822575_ChIP-Seq_HepG2_Human0.94017196
130CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93960730
131SMAD3_21741376_ChIP-Seq_EPCs_Human0.93898268
132POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93072648
133SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.93072019
134TCF4_23295773_ChIP-Seq_U87_Human0.92941080
135TP53_20018659_ChIP-ChIP_R1E_Mouse0.92463579
136SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91513825
137NFE2_27457419_Chip-Seq_LIVER_Mouse0.90892649
138HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.90445151
139PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90193591
140MYC_18940864_ChIP-ChIP_HL60_Human0.89660226
141AR_21909140_ChIP-Seq_LNCAP_Human0.89498367
142* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.89367527
143* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.88800498
144SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88297926
145TAF15_26573619_Chip-Seq_HEK293_Human0.87744718
146MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.85622839
147MYC_19829295_ChIP-Seq_ESCs_Human0.85435843
148STAT3_23295773_ChIP-Seq_U87_Human0.84813735
149ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.84480280
150AR_25329375_ChIP-Seq_VCAP_Human0.84304804
151SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84271208
152DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84232099
153TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.84188746
154TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83780797
155FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.83737026
156ZFP281_27345836_Chip-Seq_ESCs_Mouse0.83392995
157EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.83176486
158LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82409441
159STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.82310499
160ISL1_27105846_Chip-Seq_CPCs_Mouse0.81926698
161POU3F2_20337985_ChIP-ChIP_501MEL_Human0.81200375
162* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.80751972
163GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.79857062
164SUZ12_27294783_Chip-Seq_NPCs_Mouse0.78627625
165ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.77357361
166ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.76749169
167YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.76520560
168CBX2_27304074_Chip-Seq_ESCs_Mouse0.75951233
169SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.73999666
170STAT1_20625510_ChIP-Seq_HELA_Human0.73516513
171KAP1_22055183_ChIP-Seq_ESCs_Mouse0.72613839
172TET1_21451524_ChIP-Seq_MESCs_Mouse0.71264800
173GATA3_21867929_ChIP-Seq_CD8_Mouse0.71029304
174DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.70823939
175KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.68788574
176P300_18555785_Chip-Seq_ESCs_Mouse0.67756304
177DCP1A_22483619_ChIP-Seq_HELA_Human0.67337646
178MAF_26560356_Chip-Seq_TH2_Human0.66711943
179E2F1_18555785_ChIP-Seq_MESCs_Mouse0.66140289
180KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.66111354
181* STAT1_17558387_ChIP-Seq_HELA_Human0.65787727
182TP63_19390658_ChIP-ChIP_HaCaT_Human0.65081175
183* FLI1_21867929_ChIP-Seq_CD8_Mouse0.64904235
184E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.63697415
185NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.63403678
186SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.62820327

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.48007470
2MP0008877_abnormal_DNA_methylation4.46915849
3MP0008057_abnormal_DNA_replication4.28882255
4MP0003880_abnormal_central_pattern4.11517026
5MP0004859_abnormal_synaptic_plasticity3.64304842
6MP0003136_yellow_coat_color3.39150006
7MP0010094_abnormal_chromosome_stability3.38645482
8MP0001929_abnormal_gametogenesis3.21068536
9MP0008058_abnormal_DNA_repair3.07699284
10MP0003698_abnormal_male_reproductive3.05597240
11MP0002277_abnormal_respiratory_mucosa2.86354728
12MP0006292_abnormal_olfactory_placode2.84370984
13MP0002210_abnormal_sex_determination2.78232317
14MP0005423_abnormal_somatic_nervous2.77984778
15MP0004270_analgesia2.65211555
16MP0003635_abnormal_synaptic_transmissio2.64471011
17MP0005670_abnormal_white_adipose2.56825683
18MP0005408_hypopigmentation2.48267571
19MP0003111_abnormal_nucleus_morphology2.41132225
20MP0003077_abnormal_cell_cycle2.39983951
21MP0001145_abnormal_male_reproductive2.32274643
22MP0001486_abnormal_startle_reflex2.28624210
23MP0002064_seizures2.26813191
24MP0009745_abnormal_behavioral_response2.21308985
25MP0002063_abnormal_learning/memory/cond2.12419071
26MP0002272_abnormal_nervous_system2.11900320
27MP0000778_abnormal_nervous_system2.11208605
28MP0002734_abnormal_mechanical_nocicepti2.01216487
29MP0004272_abnormal_basement_membrane2.01095341
30MP0003122_maternal_imprinting2.00053914
31MP0000653_abnormal_sex_gland1.97634696
32MP0008932_abnormal_embryonic_tissue1.94479399
33MP0003693_abnormal_embryo_hatching1.93893774
34MP0002572_abnormal_emotion/affect_behav1.92337414
35MP0001968_abnormal_touch/_nociception1.91430180
36MP0009046_muscle_twitch1.89977585
37MP0001984_abnormal_olfaction1.88295135
38MP0002822_catalepsy1.84684245
39MP0000462_abnormal_digestive_system1.82430389
40MP0000566_synostosis1.71205671
41MP0002161_abnormal_fertility/fecundity1.64813596
42MP0002160_abnormal_reproductive_system1.64346835
43MP0002098_abnormal_vibrissa_morphology1.64214890
44MP0006276_abnormal_autonomic_nervous1.62428021
45MP0004381_abnormal_hair_follicle1.58662936
46MP0002557_abnormal_social/conspecific_i1.58277134
47MP0001529_abnormal_vocalization1.58040208
48MP0002653_abnormal_ependyma_morphology1.56666192
49MP0002184_abnormal_innervation1.56388533
50MP0006072_abnormal_retinal_apoptosis1.56310858
51MP0000955_abnormal_spinal_cord1.52599326
52MP0002735_abnormal_chemical_nociception1.50903188
53MP0002102_abnormal_ear_morphology1.49974923
54MP0009780_abnormal_chondrocyte_physiolo1.49502172
55MP0005646_abnormal_pituitary_gland1.47824983
56MP0002638_abnormal_pupillary_reflex1.47351911
57MP0001502_abnormal_circadian_rhythm1.46393023
58MP0001970_abnormal_pain_threshold1.45835341
59MP0004957_abnormal_blastocyst_morpholog1.42838442
60MP0005409_darkened_coat_color1.42813137
61MP0001186_pigmentation_phenotype1.40051480
62MP0004885_abnormal_endolymph1.39887900
63MP0002736_abnormal_nociception_after1.39870949
64MP0002733_abnormal_thermal_nociception1.39005449
65MP0005551_abnormal_eye_electrophysiolog1.36963658
66MP0000371_diluted_coat_color1.36457672
67MP0008995_early_reproductive_senescence1.36029750
68MP0002882_abnormal_neuron_morphology1.33341256
69MP0002396_abnormal_hematopoietic_system1.30389498
70MP0003315_abnormal_perineum_morphology1.30270875
71MP0001299_abnormal_eye_distance/1.30232803
72MP0003786_premature_aging1.28712207
73MP0000631_abnormal_neuroendocrine_gland1.27489233
74MP0002132_abnormal_respiratory_system1.26160887
75MP0001485_abnormal_pinna_reflex1.24840379
76MP0005174_abnormal_tail_pigmentation1.24075323
77MP0004811_abnormal_neuron_physiology1.23787558
78MP0002067_abnormal_sensory_capabilities1.23257261
79MP0008007_abnormal_cellular_replicative1.21254647
80MP0010030_abnormal_orbit_morphology1.19847401
81MP0002152_abnormal_brain_morphology1.19846487
82MP0003119_abnormal_digestive_system1.19323024
83MP0002075_abnormal_coat/hair_pigmentati1.18588661
84MP0008789_abnormal_olfactory_epithelium1.17496254
85MP0008569_lethality_at_weaning1.16796901
86MP0005171_absent_coat_pigmentation1.16168872
87MP0003283_abnormal_digestive_organ1.15546662
88MP0000026_abnormal_inner_ear1.15470280
89MP0001177_atelectasis1.14844818
90MP0004133_heterotaxia1.14661866
91MP0005645_abnormal_hypothalamus_physiol1.14306028
92MP0003121_genomic_imprinting1.12681178
93MP0001963_abnormal_hearing_physiology1.10626791
94MP0002066_abnormal_motor_capabilities/c1.07777066
95MP0002752_abnormal_somatic_nervous1.07337040
96MP0004924_abnormal_behavior1.06893489
97MP0005386_behavior/neurological_phenoty1.06893489
98MP0000049_abnormal_middle_ear1.01137159
99MP0002938_white_spotting1.00676914
100MP0001501_abnormal_sleep_pattern1.00485514
101MP0003385_abnormal_body_wall0.98841527
102MP0003938_abnormal_ear_development0.98814442
103MP0005394_taste/olfaction_phenotype0.97891558
104MP0005499_abnormal_olfactory_system0.97891558
105MP0001293_anophthalmia0.96915413
106MP0002282_abnormal_trachea_morphology0.95296553
107MP0000015_abnormal_ear_pigmentation0.94704527
108MP0003448_altered_tumor_morphology0.94503220
109MP0003937_abnormal_limbs/digits/tail_de0.93431139
110MP0004197_abnormal_fetal_growth/weight/0.93133585
111MP0005377_hearing/vestibular/ear_phenot0.92854202
112MP0003878_abnormal_ear_physiology0.92854202
113MP0003123_paternal_imprinting0.90914637
114MP0003329_amyloid_beta_deposits0.90037153
115MP0003787_abnormal_imprinting0.89349328
116MP0004742_abnormal_vestibular_system0.87338861
117MP0004142_abnormal_muscle_tone0.86454451
118MP0002234_abnormal_pharynx_morphology0.86299897
119MP0003633_abnormal_nervous_system0.85978779
120MP0004808_abnormal_hematopoietic_stem0.83654609
121MP0001986_abnormal_taste_sensitivity0.82793035
122MP0009379_abnormal_foot_pigmentation0.82723088
123MP0001730_embryonic_growth_arrest0.82257033
124MP0000372_irregular_coat_pigmentation0.80956834
125MP0002085_abnormal_embryonic_tissue0.80897953
126MP0002233_abnormal_nose_morphology0.80861244
127MP0002249_abnormal_larynx_morphology0.80274707
128MP0000313_abnormal_cell_death0.80180384
129MP0005391_vision/eye_phenotype0.79231469
130MP0002069_abnormal_eating/drinking_beha0.78374028
131MP0001905_abnormal_dopamine_level0.77789732
132MP0005167_abnormal_blood-brain_barrier0.77420735
133MP0000350_abnormal_cell_proliferation0.77150816
134MP0004043_abnormal_pH_regulation0.77074723
135MP0002909_abnormal_adrenal_gland0.76834645
136MP0003631_nervous_system_phenotype0.76710285
137MP0000703_abnormal_thymus_morphology0.74341246
138MP0005253_abnormal_eye_physiology0.74327588
139MP0002116_abnormal_craniofacial_bone0.73850003
140MP0003755_abnormal_palate_morphology0.73476290
141MP0005389_reproductive_system_phenotype0.73468202
142MP0002229_neurodegeneration0.73108461
143MP0003861_abnormal_nervous_system0.72458857
144MP0003718_maternal_effect0.71415649
145MP0000428_abnormal_craniofacial_morphol0.70912376
146MP0000685_abnormal_immune_system0.70517908
147MP0002751_abnormal_autonomic_nervous0.69015327
148MP0009703_decreased_birth_body0.68253947
149MP0004147_increased_porphyrin_level0.68185318
150MP0000537_abnormal_urethra_morphology0.67950202
151MP0000613_abnormal_salivary_gland0.67913972
152MP0008872_abnormal_physiological_respon0.67907264
153MP0001270_distended_abdomen0.67109878
154MP0003632_abnormal_nervous_system0.66697430
155MP0002092_abnormal_eye_morphology0.64773140
156MP0002084_abnormal_developmental_patter0.64308763
157MP0002095_abnormal_skin_pigmentation0.63610773
158MP0001697_abnormal_embryo_size0.61739719
159MP0000647_abnormal_sebaceous_gland0.61094381
160MP0005075_abnormal_melanosome_morpholog0.61061397
161MP0002932_abnormal_joint_morphology0.58291708
162MP0001661_extended_life_span0.57997067
163MP0002089_abnormal_postnatal_growth/wei0.51687827
164MP0003890_abnormal_embryonic-extraembry0.51660734
165MP0002114_abnormal_axial_skeleton0.51512276
166MP0003115_abnormal_respiratory_system0.51208575
167MP0001188_hyperpigmentation0.50342170
168MP0003699_abnormal_female_reproductive0.49813241
169MP0002080_prenatal_lethality0.49401406

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.79693902
2Dynein arm defect of respiratory motile cilia (HP:0012255)7.25026385
3Absent/shortened dynein arms (HP:0200106)7.25026385
4Abnormal respiratory motile cilium physiology (HP:0012261)5.30944966
5Abnormal respiratory motile cilium morphology (HP:0005938)5.27776546
6Abnormal respiratory epithelium morphology (HP:0012253)5.27776546
7Abnormal ciliary motility (HP:0012262)4.33560610
8Myokymia (HP:0002411)4.23675593
9Rhinitis (HP:0012384)4.15682114
10Chromosomal breakage induced by crosslinking agents (HP:0003221)3.97560453
11Chronic bronchitis (HP:0004469)3.95416057
12Focal motor seizures (HP:0011153)3.74532060
13Focal seizures (HP:0007359)3.69701769
14Chromsome breakage (HP:0040012)3.40421006
15Medulloblastoma (HP:0002885)3.38642779
16Supernumerary bones of the axial skeleton (HP:0009144)3.25996329
17Duplicated collecting system (HP:0000081)3.13920223
18Supernumerary ribs (HP:0005815)3.13233980
19Infertility (HP:0000789)3.01325402
20Meckel diverticulum (HP:0002245)2.97179537
21Epileptic encephalopathy (HP:0200134)2.91228794
22Breast hypoplasia (HP:0003187)2.90438814
23Supernumerary spleens (HP:0009799)2.87092894
24Febrile seizures (HP:0002373)2.84949344
25Nasal polyposis (HP:0100582)2.84492900
26Hyperventilation (HP:0002883)2.83878785
27Abnormality of the ileum (HP:0001549)2.80983937
28Hemiparesis (HP:0001269)2.79233761
29Nephronophthisis (HP:0000090)2.73041228
30Selective tooth agenesis (HP:0001592)2.69493748
31Abnormality of cells of the erythroid lineage (HP:0012130)2.67299472
32Abnormality of the renal collecting system (HP:0004742)2.62629700
33Abnormal spermatogenesis (HP:0008669)2.59730937
34Abnormality of the carotid arteries (HP:0005344)2.58750990
35Bronchiectasis (HP:0002110)2.57480214
36Limb dystonia (HP:0002451)2.56188655
37Action tremor (HP:0002345)2.53599851
38Aplastic anemia (HP:0001915)2.52759612
39Reticulocytopenia (HP:0001896)2.52556720
40Ectopic kidney (HP:0000086)2.50541737
41Abnormal number of erythroid precursors (HP:0012131)2.48249707
42Aplasia/Hypoplasia of the uvula (HP:0010293)2.46372706
43Gait imbalance (HP:0002141)2.45135430
44Amyotrophic lateral sclerosis (HP:0007354)2.41826482
45Gonadotropin excess (HP:0000837)2.40554653
46Ankle clonus (HP:0011448)2.38610697
47Amblyopia (HP:0000646)2.38446601
48Agnosia (HP:0010524)2.37970248
49Impulsivity (HP:0100710)2.37178768
50Overriding aorta (HP:0002623)2.35367617
51Bronchitis (HP:0012387)2.34962106
52Abnormality of the preputium (HP:0100587)2.33593644
53Retinal dysplasia (HP:0007973)2.32386401
54Drooling (HP:0002307)2.29432215
55Abnormality of the labia minora (HP:0012880)2.26702014
56Abnormality of the fetal cardiovascular system (HP:0010948)2.25788354
57Abnormal umbilical cord blood vessels (HP:0011403)2.25788354
58Single umbilical artery (HP:0001195)2.25788354
59Atonic seizures (HP:0010819)2.25706842
60Progressive cerebellar ataxia (HP:0002073)2.24825881
61Renovascular hypertension (HP:0100817)2.24274412
62Generalized tonic-clonic seizures (HP:0002069)2.23203511
63Sleep apnea (HP:0010535)2.19115618
64Abnormality of the nasal mucosa (HP:0000433)2.18562679
65Broad-based gait (HP:0002136)2.17573963
66Abnormality of chromosome stability (HP:0003220)2.16691278
67Medial flaring of the eyebrow (HP:0010747)2.15438906
68Median cleft lip (HP:0000161)2.15001360
69Type II lissencephaly (HP:0007260)2.14516756
70Hypoplasia of the radius (HP:0002984)2.13676284
71Abnormality of the parietal bone (HP:0002696)2.12645341
72Abnormality of midbrain morphology (HP:0002418)2.10911028
73Molar tooth sign on MRI (HP:0002419)2.10911028
74Renal tubular acidosis (HP:0001947)2.08742145
75Absent frontal sinuses (HP:0002688)2.08235105
76Fibular hypoplasia (HP:0003038)2.07209211
77Abnormality of the diencephalon (HP:0010662)2.06042385
78Genital tract atresia (HP:0001827)2.04949026
79Absent speech (HP:0001344)2.04614395
80Progressive external ophthalmoplegia (HP:0000590)2.04084743
81Ependymoma (HP:0002888)2.02382930
82Abnormality of the lower motor neuron (HP:0002366)2.02054209
83Poor speech (HP:0002465)2.01629483
8411 pairs of ribs (HP:0000878)2.01568581
85Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.00914139
86Short 4th metacarpal (HP:0010044)2.00914139
87Abnormality of the renal medulla (HP:0100957)2.00755857
88Congenital primary aphakia (HP:0007707)2.00071507
89Azoospermia (HP:0000027)2.00000600
90Short ribs (HP:0000773)1.99405792
91Small intestinal stenosis (HP:0012848)1.99244277
92Duodenal stenosis (HP:0100867)1.99244277
93Vaginal atresia (HP:0000148)1.98658468
94Duplication of thumb phalanx (HP:0009942)1.96420925
95Excessive salivation (HP:0003781)1.96395954
96Spastic gait (HP:0002064)1.96247145
97Intestinal atresia (HP:0011100)1.95437972
98Absent septum pellucidum (HP:0001331)1.94360827
99Abnormal eating behavior (HP:0100738)1.94226264
100Abnormal lung lobation (HP:0002101)1.92282111
101Flat cornea (HP:0007720)1.92002382
102Hyperacusis (HP:0010780)1.91654841
103Turricephaly (HP:0000262)1.91459924
104Insomnia (HP:0100785)1.91455417
105Abnormality of the dental pulp (HP:0006479)1.89873748
106Triphalangeal thumb (HP:0001199)1.89123249
107Aplasia/Hypoplasia of the sacrum (HP:0008517)1.89048700
108Vitreoretinal degeneration (HP:0000655)1.88671576
109Epileptiform EEG discharges (HP:0011182)1.88343900
110Absent radius (HP:0003974)1.87590795
111Lissencephaly (HP:0001339)1.87178856
112Shawl scrotum (HP:0000049)1.86319408
113Absent thumb (HP:0009777)1.85763986
114Torticollis (HP:0000473)1.85758275
115Nephroblastoma (Wilms tumor) (HP:0002667)1.85566412
116Abnormality of permanent molar morphology (HP:0011071)1.85516959
117Abnormality of the dental root (HP:0006486)1.85516959
118Taurodontia (HP:0000679)1.85516959
119Short thumb (HP:0009778)1.84762307
120Status epilepticus (HP:0002133)1.84658427
121Hypsarrhythmia (HP:0002521)1.83920861
122Hypoplastic ischia (HP:0003175)1.82919827
123EEG with generalized epileptiform discharges (HP:0011198)1.82822060
124Rib fusion (HP:0000902)1.81487909
125Abnormality of the aortic arch (HP:0012303)1.81318498
126Neoplasm of the oral cavity (HP:0100649)1.80951134
127Aplasia involving forearm bones (HP:0009822)1.80302905
128Absent forearm bone (HP:0003953)1.80302905
129Megalencephaly (HP:0001355)1.80133806
130Cerebellar dysplasia (HP:0007033)1.80083050
131Dialeptic seizures (HP:0011146)1.79741943
132Abnormality of molar (HP:0011077)1.79531144
133Abnormality of molar morphology (HP:0011070)1.79531144
134Short middle phalanx of the 5th finger (HP:0004220)1.79312562
135Nephrogenic diabetes insipidus (HP:0009806)1.77584719
136Optic nerve hypoplasia (HP:0000609)1.76815850
137Sloping forehead (HP:0000340)1.76561220
138Protruding tongue (HP:0010808)1.74440547
139Renal duplication (HP:0000075)1.74417536
140Abnormality of the ischium (HP:0003174)1.74251996
141Gaze-evoked nystagmus (HP:0000640)1.74148556
142Specific learning disability (HP:0001328)1.74030525
143Hepatoblastoma (HP:0002884)1.73632884
144Abnormality of the septum pellucidum (HP:0007375)1.73461395
145Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.73158922
146Pancreatic fibrosis (HP:0100732)1.72886969
147Pachygyria (HP:0001302)1.72795717
148Cystic liver disease (HP:0006706)1.72254822
149Abnormality of the astrocytes (HP:0100707)1.72128188
150Astrocytoma (HP:0009592)1.72128188
151Inability to walk (HP:0002540)1.70801955
152Aplasia/Hypoplasia of the earlobes (HP:0009906)1.69773771
153Elfin facies (HP:0004428)1.69478442
154Anophthalmia (HP:0000528)1.69423309
155Postaxial foot polydactyly (HP:0001830)1.69225405
156Anencephaly (HP:0002323)1.68700955
157Poor eye contact (HP:0000817)1.68410092
158Bronchomalacia (HP:0002780)1.68028597
159Focal dystonia (HP:0004373)1.67660965
160Polyphagia (HP:0002591)1.67655840
161Impaired vibration sensation in the lower limbs (HP:0002166)1.67283705
162Clubbing of toes (HP:0100760)1.67003151
163Recurrent otitis media (HP:0000403)1.67003073
164Occipital encephalocele (HP:0002085)1.66903932
165Abnormality of the corticospinal tract (HP:0002492)1.66785819
166Patellar aplasia (HP:0006443)1.66410621
167Septo-optic dysplasia (HP:0100842)1.66319742
168Embryonal renal neoplasm (HP:0011794)1.65716252
169Oligodactyly (hands) (HP:0001180)1.65616028
170Neoplasm of the heart (HP:0100544)1.64781283
171Gastrointestinal atresia (HP:0002589)1.64779286
172Poor coordination (HP:0002370)1.64026437
173Down-sloping shoulders (HP:0200021)1.63455831
174Truncal ataxia (HP:0002078)1.61998056
175Tubulointerstitial nephritis (HP:0001970)1.60606537
176Glioma (HP:0009733)1.58055411
177Pancreatic cysts (HP:0001737)1.57787285
178Preaxial foot polydactyly (HP:0001841)1.56985101
179Colon cancer (HP:0003003)1.56928591
180Urinary urgency (HP:0000012)1.56794479
181Alacrima (HP:0000522)1.56647176
182Akinesia (HP:0002304)1.55712753
183Renal hypoplasia (HP:0000089)1.55554981
184Renal dysplasia (HP:0000110)1.55149638
185Bell-shaped thorax (HP:0001591)1.54069095
186Obstructive sleep apnea (HP:0002870)1.53593054
187Cutaneous finger syndactyly (HP:0010554)1.52652778
188Thickened helices (HP:0000391)1.51421873
189Split foot (HP:0001839)1.50794247
190Aplasia/Hypoplasia of the patella (HP:0006498)1.50367215
191Coronal craniosynostosis (HP:0004440)1.49289191
192Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.48993809
193Postaxial hand polydactyly (HP:0001162)1.48583163
194Optic nerve coloboma (HP:0000588)1.48301552
195Peripheral hypomyelination (HP:0007182)1.48099721

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K104.51593791
2EPHA43.82218176
3TLK13.14637505
4PDK32.79317287
5PDK42.79317287
6NTRK32.73186456
7CASK2.72235981
8NTRK22.58053190
9CDC72.53940314
10DAPK22.45358791
11MAP3K42.30335716
12WNK32.29806835
13PAK62.26012560
14MAPK132.17354354
15PLK42.02671202
16CDK1912.5307830
17DYRK21.93804601
18PDK21.75816699
19UHMK11.71749920
20FGFR21.69198391
21MAP4K21.67593968
22NTRK11.64008075
23TESK11.62977462
24IRAK11.60636923
25MINK11.54347246
26PLK21.54229388
27PNCK1.44897123
28MAP2K71.42398452
29PINK11.42359228
30WEE11.41617072
31BUB11.39138806
32STK41.36227268
33NEK21.33925458
34PRKCG1.29764891
35MKNK21.27952077
36CAMKK11.27800291
37PAK31.23363477
38CAMK1G1.21519737
39STK161.20182818
40SIK21.18094439
41SGK4941.17895025
42SGK2231.17895025
43ICK1.17251029
44FRK1.14145771
45MAP2K31.13023842
46EPHB21.12175212
47SRPK11.11344835
48TTK1.08981693
49CAMK11.05758151
50CSNK1G21.04069224
51IRAK31.02716048
52DYRK31.02524169
53CDK41.00642141
54CLK10.99697429
55STK390.99547422
56CAMK1D0.95712845
57VRK20.95607396
58GRK10.94896699
59MKNK10.92376516
60CDK50.91137492
61ACVR1B0.87934933
62NEK60.87459960
63SGK20.87343114
64CDK11A0.86225180
65CHEK20.85762617
66ATR0.85120311
67CAMK2B0.83670118
68PASK0.79022601
69CAMK40.78971679
70CDK70.78623148
71PRKCE0.75354322
72STK110.72898249
73TNK20.72380465
74AKT30.71677104
75DAPK10.71429522
76IRAK20.70890236
77CAMK2A0.70870877
78PLK10.66322140
79PRKCH0.65163139
80MAP2K60.64345816
81CDK30.61370381
82LIMK10.61198722
83CAMK2G0.61101735
84PRKAA10.60051375
85IRAK40.59781107
86PRKCZ0.59682390
87INSRR0.59376507
88PRKD20.57759170
89NME10.56708042
90CAMK2D0.56158247
91BRD40.55702990
92PRKD30.54484226
93GRK50.53367507
94ZAK0.53175921
95BCKDK0.52698030
96WNK40.52652783
97EPHA30.52174357
98DDR20.51555275
99PKN10.50350588
100ATM0.49951639
101VRK10.49888855
102TAF10.49853680
103NUAK10.48388536
104ERBB20.47938065
105AURKA0.47399191
106MAPK150.47378069
107CHEK10.47245314
108TNIK0.47028805
109CDK140.46515810
110OXSR10.45932960
111CSNK1A10.45412981
112ROCK10.45316760
113PTK2B0.44904789
114FLT30.44168684
115ADRBK20.43436950
116SGK10.42794812
117BMPR1B0.42445871
118MAPK120.39567759
119CSNK1G30.37621694
120PLK30.37211636
121BRSK20.36156670
122CSNK1A1L0.35835780
123CDK20.35585934
124STK100.34176537
125BCR0.32767092
126MAP3K80.32328466
127TESK20.31846025
128MARK10.29740076
129EPHA20.29214056
130PRKCI0.28228763
131MAPK40.28008977
132EEF2K0.27365029
133AURKB0.26959603
134MAP2K40.25099376
135YES10.24579318
136CDK10.24359977
137FES0.24165856
138CSNK1G10.23957583
139PRKDC0.23730216
140CCNB10.23701741
141MAPK90.22596595
142STK380.21544420
143MARK20.21529203
144PAK10.19432592
145CSNK2A20.17401299
146CDK150.17172423
147PAK40.16593998
148CSNK1E0.16456868
149DYRK1A0.16359206
150CSNK1D0.16328254
151TSSK60.16298838
152GSK3B0.16024163
153WNK10.15757190
154CDK90.15637070
155MTOR0.15072969
156CSNK2A10.14664137
157CDK180.14341402
158TGFBR10.13928580
159TYRO30.13769053
160PHKG20.13341811
161PHKG10.13341811
162MAPKAPK50.12832636

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.48013653
2Mismatch repair_Homo sapiens_hsa034304.08434933
3Nicotine addiction_Homo sapiens_hsa050333.55007128
4Fanconi anemia pathway_Homo sapiens_hsa034603.32505051
5Renin-angiotensin system_Homo sapiens_hsa046143.18114206
6Ribosome_Homo sapiens_hsa030103.17989475
7Homologous recombination_Homo sapiens_hsa034403.00772909
8Spliceosome_Homo sapiens_hsa030402.73818467
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.63860156
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.60256370
11Basal transcription factors_Homo sapiens_hsa030222.56399783
12RNA transport_Homo sapiens_hsa030132.53795431
13Base excision repair_Homo sapiens_hsa034102.45190337
14Nucleotide excision repair_Homo sapiens_hsa034202.29745660
15Synaptic vesicle cycle_Homo sapiens_hsa047212.20690778
16RNA polymerase_Homo sapiens_hsa030202.18330945
17Insulin secretion_Homo sapiens_hsa049112.11266958
18Circadian entrainment_Homo sapiens_hsa047132.10015481
19Cell cycle_Homo sapiens_hsa041102.09162382
20Glutamatergic synapse_Homo sapiens_hsa047242.07571669
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.03049475
22Pyrimidine metabolism_Homo sapiens_hsa002402.01962728
23GABAergic synapse_Homo sapiens_hsa047271.98681536
24African trypanosomiasis_Homo sapiens_hsa051431.88264883
25mRNA surveillance pathway_Homo sapiens_hsa030151.82391765
26Dopaminergic synapse_Homo sapiens_hsa047281.74173723
27Amphetamine addiction_Homo sapiens_hsa050311.74159512
28Morphine addiction_Homo sapiens_hsa050321.71984558
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.71746684
30Cocaine addiction_Homo sapiens_hsa050301.70784286
31Non-homologous end-joining_Homo sapiens_hsa034501.70272416
32Vitamin B6 metabolism_Homo sapiens_hsa007501.61411466
33RNA degradation_Homo sapiens_hsa030181.60560547
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59930210
35Proteasome_Homo sapiens_hsa030501.56241590
36Butanoate metabolism_Homo sapiens_hsa006501.55639729
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.52528872
38Linoleic acid metabolism_Homo sapiens_hsa005911.52154696
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.52136033
40Systemic lupus erythematosus_Homo sapiens_hsa053221.51613883
41Oocyte meiosis_Homo sapiens_hsa041141.44208356
42Purine metabolism_Homo sapiens_hsa002301.42278714
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.41474083
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.35995882
45Taste transduction_Homo sapiens_hsa047421.33665260
46Mineral absorption_Homo sapiens_hsa049781.32350057
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.28923176
48Gastric acid secretion_Homo sapiens_hsa049711.23666955
49Huntingtons disease_Homo sapiens_hsa050161.18505734
50Cholinergic synapse_Homo sapiens_hsa047251.15851174
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.13303774
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.12062060
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.11157196
54Cyanoamino acid metabolism_Homo sapiens_hsa004601.08105404
55Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.07778967
56Salivary secretion_Homo sapiens_hsa049701.05727054
57Propanoate metabolism_Homo sapiens_hsa006400.99382672
58Melanogenesis_Homo sapiens_hsa049160.98683239
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98051230
60p53 signaling pathway_Homo sapiens_hsa041150.97614494
61Ether lipid metabolism_Homo sapiens_hsa005650.97438487
62Histidine metabolism_Homo sapiens_hsa003400.97339820
63Long-term depression_Homo sapiens_hsa047300.96899610
64cAMP signaling pathway_Homo sapiens_hsa040240.96857001
65Thyroid hormone synthesis_Homo sapiens_hsa049180.96759864
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.96041864
67Long-term potentiation_Homo sapiens_hsa047200.96016943
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.94407314
69Arginine and proline metabolism_Homo sapiens_hsa003300.94350825
70Oxytocin signaling pathway_Homo sapiens_hsa049210.93242995
71Calcium signaling pathway_Homo sapiens_hsa040200.92999760
72Hippo signaling pathway_Homo sapiens_hsa043900.92338073
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91612373
74Basal cell carcinoma_Homo sapiens_hsa052170.90137869
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89075215
76Olfactory transduction_Homo sapiens_hsa047400.88389560
77Hedgehog signaling pathway_Homo sapiens_hsa043400.88130595
78Bile secretion_Homo sapiens_hsa049760.87878370
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87776039
80Epstein-Barr virus infection_Homo sapiens_hsa051690.87387669
81Serotonergic synapse_Homo sapiens_hsa047260.84245463
82Alcoholism_Homo sapiens_hsa050340.83757071
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82478350
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81780936
85Renin secretion_Homo sapiens_hsa049240.81398627
86Sulfur relay system_Homo sapiens_hsa041220.80470615
87Arachidonic acid metabolism_Homo sapiens_hsa005900.80010545
88Fatty acid metabolism_Homo sapiens_hsa012120.79894930
89Arginine biosynthesis_Homo sapiens_hsa002200.76809021
90ABC transporters_Homo sapiens_hsa020100.76141732
91Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72573537
92Fatty acid degradation_Homo sapiens_hsa000710.69891002
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.68968856
94HTLV-I infection_Homo sapiens_hsa051660.67311638
95beta-Alanine metabolism_Homo sapiens_hsa004100.66261783
96Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66043953
97Steroid biosynthesis_Homo sapiens_hsa001000.65721068
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65231034
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65173286
100Primary immunodeficiency_Homo sapiens_hsa053400.63308556
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63251289
102Cardiac muscle contraction_Homo sapiens_hsa042600.63166274
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62870471
104Sphingolipid metabolism_Homo sapiens_hsa006000.62812314
105Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61930191
106Estrogen signaling pathway_Homo sapiens_hsa049150.61506059
107Regulation of autophagy_Homo sapiens_hsa041400.61029999
108Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60640843
109Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60314434
110Oxidative phosphorylation_Homo sapiens_hsa001900.60167371
111Tryptophan metabolism_Homo sapiens_hsa003800.59468695
112Herpes simplex infection_Homo sapiens_hsa051680.59452661
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.59270971
114Viral carcinogenesis_Homo sapiens_hsa052030.58113358
1152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56840030
116Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56041126
117Wnt signaling pathway_Homo sapiens_hsa043100.55599426
118Notch signaling pathway_Homo sapiens_hsa043300.54895773
119Gap junction_Homo sapiens_hsa045400.54082657
120Parkinsons disease_Homo sapiens_hsa050120.54072563
121Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53830769
122AMPK signaling pathway_Homo sapiens_hsa041520.53532396
123Dorso-ventral axis formation_Homo sapiens_hsa043200.53476724
124Vascular smooth muscle contraction_Homo sapiens_hsa042700.49065748
125Caffeine metabolism_Homo sapiens_hsa002320.47944987
126Peroxisome_Homo sapiens_hsa041460.47219069
127Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46989221
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.46675927
129Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46334010
130Axon guidance_Homo sapiens_hsa043600.45860899
131Glucagon signaling pathway_Homo sapiens_hsa049220.43265096
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42653730
133Antigen processing and presentation_Homo sapiens_hsa046120.41996331
134Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41945602
135One carbon pool by folate_Homo sapiens_hsa006700.36921293
136Alzheimers disease_Homo sapiens_hsa050100.34052996
137Vitamin digestion and absorption_Homo sapiens_hsa049770.32873572
138T cell receptor signaling pathway_Homo sapiens_hsa046600.28836054
139Phototransduction_Homo sapiens_hsa047440.28396533
140MicroRNAs in cancer_Homo sapiens_hsa052060.27578268
141Pentose phosphate pathway_Homo sapiens_hsa000300.26379117
142Glutathione metabolism_Homo sapiens_hsa004800.26357231
143Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.24698713
144Pyruvate metabolism_Homo sapiens_hsa006200.23611396
145MAPK signaling pathway_Homo sapiens_hsa040100.23146652
146Fatty acid biosynthesis_Homo sapiens_hsa000610.23068723
147Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.22613893
148Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.20657637
149Autoimmune thyroid disease_Homo sapiens_hsa053200.19861023
150Lysine degradation_Homo sapiens_hsa003100.18015446
151Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.17791328
152Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.17521552
153Selenocompound metabolism_Homo sapiens_hsa004500.17403843
154Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16919724
155Metabolic pathways_Homo sapiens_hsa011000.16314691
156Pathways in cancer_Homo sapiens_hsa052000.15490094
157ECM-receptor interaction_Homo sapiens_hsa045120.15205139
158Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.14768603
159Protein digestion and absorption_Homo sapiens_hsa049740.14176816
160Shigellosis_Homo sapiens_hsa051310.13134900
161VEGF signaling pathway_Homo sapiens_hsa043700.12883683
162Ovarian steroidogenesis_Homo sapiens_hsa049130.12748666
163NF-kappa B signaling pathway_Homo sapiens_hsa040640.12472444
164Measles_Homo sapiens_hsa051620.12310818
165Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.11935346
166Glycerolipid metabolism_Homo sapiens_hsa005610.11538514
167NOD-like receptor signaling pathway_Homo sapiens_hsa046210.11492408
168RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.11437838
169Phospholipase D signaling pathway_Homo sapiens_hsa040720.10843764
170Hematopoietic cell lineage_Homo sapiens_hsa046400.10316728

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