MUCL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of activation of Janus kinase activity (GO:0010533)9.28446953
2negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)8.41599714
3molting cycle (GO:0042303)8.07689351
4hair cycle (GO:0042633)8.07689351
5retina homeostasis (GO:0001895)7.65530540
6purine nucleotide transport (GO:0015865)7.54402469
7T-helper 1 type immune response (GO:0042088)7.36404388
8positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)7.33029048
9positive regulation of chemokine secretion (GO:0090197)7.10242928
10regulation of cytokine production involved in inflammatory response (GO:1900015)7.10196236
11linoleic acid metabolic process (GO:0043651)6.65195204
12regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)6.55179573
13positive regulation of keratinocyte differentiation (GO:0045618)6.55014309
14regulation of lipoprotein metabolic process (GO:0050746)6.36619238
15regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)6.34874648
16regulation of chemokine secretion (GO:0090196)6.20632051
17regulation of memory T cell differentiation (GO:0043380)6.19616615
18primary alcohol catabolic process (GO:0034310)5.98489138
19positive regulation of alpha-beta T cell proliferation (GO:0046641)5.97381921
20positive regulation of T-helper cell differentiation (GO:0045624)5.83634077
21keratinization (GO:0031424)5.72549504
22negative regulation of focal adhesion assembly (GO:0051895)5.72465261
23negative regulation of cell junction assembly (GO:1901889)5.72465261
24negative regulation of adherens junction organization (GO:1903392)5.72465261
25positive regulation of T-helper 1 type immune response (GO:0002827)5.58271073
26negative regulation of bone mineralization (GO:0030502)5.44363401
27short-chain fatty acid metabolic process (GO:0046459)5.42384844
28establishment of skin barrier (GO:0061436)5.33920075
29regulation of water loss via skin (GO:0033561)5.28709469
30positive regulation of immune response to tumor cell (GO:0002839)5.28060857
31regulation of immune response to tumor cell (GO:0002837)5.28060857
32regulation of response to tumor cell (GO:0002834)5.28060857
33positive regulation of response to tumor cell (GO:0002836)5.28060857
34negative regulation of chemokine production (GO:0032682)5.24553617
35positive regulation of monocyte chemotaxis (GO:0090026)5.22029599
36regulation of alpha-beta T cell proliferation (GO:0046640)5.20303865
37negative regulation of interleukin-17 production (GO:0032700)5.19972502
38sexual reproduction (GO:0019953)5.12131269
39defense response to protozoan (GO:0042832)5.11733593
40negative regulation of biomineral tissue development (GO:0070168)5.00356519
41regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)4.95435164
42positive regulation of interleukin-17 production (GO:0032740)4.92420427
43desmosome organization (GO:0002934)4.90710588
44positive regulation of epidermal cell differentiation (GO:0045606)4.90494394
45positive regulation of defense response to virus by host (GO:0002230)4.89443837
46positive regulation of interleukin-12 production (GO:0032735)4.80638863
47positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.71588454
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.64009229
49positive regulation of type 2 immune response (GO:0002830)4.59774507
50lipoxygenase pathway (GO:0019372)4.49825843
51ethanol metabolic process (GO:0006067)4.45389062
52response to peptidoglycan (GO:0032494)4.43982770
53regulation of T-helper 1 type immune response (GO:0002825)4.42680513
54positive regulation of interferon-alpha production (GO:0032727)4.42454915
55adhesion of symbiont to host cell (GO:0044650)4.41246476
56virion attachment to host cell (GO:0019062)4.41246476
57long-chain fatty acid biosynthetic process (GO:0042759)4.39757953
58production of molecular mediator involved in inflammatory response (GO:0002532)4.39114197
59regulation of female receptivity (GO:0045924)4.32007081
60positive regulation of interferon-gamma biosynthetic process (GO:0045078)4.31916227
61response to protozoan (GO:0001562)4.29241622
62regulation of T-helper cell differentiation (GO:0045622)4.27643201
63regulation of keratinocyte differentiation (GO:0045616)4.26055861
64neutrophil activation involved in immune response (GO:0002283)4.25567342
65negative regulation of smooth muscle cell proliferation (GO:0048662)4.23390111
66axon regeneration (GO:0031103)4.21784362
67regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)4.21104228
68peptide cross-linking (GO:0018149)4.20429082
69negative regulation of leukocyte migration (GO:0002686)4.20417479
70benzene-containing compound metabolic process (GO:0042537)4.19256588
71immunoglobulin mediated immune response (GO:0016064)4.14362016
72regulation of interferon-alpha production (GO:0032647)4.10150363
73multicellular organismal water homeostasis (GO:0050891)4.02962202
74regulation of interleukin-12 biosynthetic process (GO:0045075)3.99777033
75antigen processing and presentation of endogenous antigen (GO:0019883)3.96602920
76positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.95207583
77surfactant homeostasis (GO:0043129)3.94372905
78detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.92710817
79positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.92477817
80positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.90554051
81endothelial cell chemotaxis (GO:0035767)3.90026589
82positive regulation of macrophage cytokine production (GO:0060907)3.85507534
83positive regulation of response to biotic stimulus (GO:0002833)3.84461336
84positive regulation of interleukin-10 production (GO:0032733)3.82943357
85intermediate filament organization (GO:0045109)3.82191391
86positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.81825125
87positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.78307989
88T-helper cell differentiation (GO:0042093)3.77103260
89CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.77103260
90regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.76135572
91negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.75485287
92lymphocyte chemotaxis (GO:0048247)3.75226089
93positive regulation of T cell mediated cytotoxicity (GO:0001916)3.74245769
94regulation of T-helper 2 cell differentiation (GO:0045628)3.74108837
95cellular response to interferon-beta (GO:0035458)3.73129073
96adhesion of symbiont to host (GO:0044406)3.70468830
97positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.70012233
98positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)3.67413690
99regulation of monocyte chemotaxis (GO:0090025)3.67274419
100insulin-like growth factor receptor signaling pathway (GO:0048009)3.67165121
101T cell migration (GO:0072678)3.63033638
102bundle of His cell to Purkinje myocyte communication (GO:0086069)3.62899745
103regulation of interleukin-17 production (GO:0032660)3.61821347
104female mating behavior (GO:0060180)3.57467105
105regulation of interferon-gamma biosynthetic process (GO:0045072)3.56921894
106positive regulation of activated T cell proliferation (GO:0042104)3.55843519
107regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.54218197
108regulation of interleukin-12 production (GO:0032655)3.53706624
109water homeostasis (GO:0030104)3.53335283
110intestinal epithelial cell development (GO:0060576)3.52917030
111natural killer cell activation involved in immune response (GO:0002323)3.49971234
112regulation of interferon-beta biosynthetic process (GO:0045357)3.49096538
113lipopolysaccharide-mediated signaling pathway (GO:0031663)3.48603262
114nucleotide transport (GO:0006862)3.47726090
115regulation of type 2 immune response (GO:0002828)3.47569218
116keratinocyte differentiation (GO:0030216)3.46996215
117positive regulation of tumor necrosis factor production (GO:0032760)3.43215658
118positive regulation of interleukin-2 production (GO:0032743)3.40242856
119regulation of defense response to virus by host (GO:0050691)3.40023209
120B cell mediated immunity (GO:0019724)3.38633343
121regulation of T cell migration (GO:2000404)3.38086952
122interferon-gamma-mediated signaling pathway (GO:0060333)3.35209343
123glomerular filtration (GO:0003094)3.34851246
124negative regulation of cell-matrix adhesion (GO:0001953)3.33379386
125regulation of T cell chemotaxis (GO:0010819)3.32157914
126positive regulation of T cell chemotaxis (GO:0010820)3.32157914
127neuron projection regeneration (GO:0031102)3.30275825
128positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.27665898
129fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.26646809
130T cell differentiation involved in immune response (GO:0002292)3.23417026
131alpha-beta T cell differentiation involved in immune response (GO:0002293)3.23417026
132alpha-beta T cell activation involved in immune response (GO:0002287)3.23417026
133positive regulation of prostaglandin secretion (GO:0032308)3.22775407
134regulation of dendritic cell antigen processing and presentation (GO:0002604)3.22060080
135positive regulation of NF-kappaB import into nucleus (GO:0042346)3.22016186
136positive regulation of cell fate commitment (GO:0010455)3.20788152
137keratinocyte proliferation (GO:0043616)3.20078336
138detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.20008605
139regulation of T cell mediated cytotoxicity (GO:0001914)3.18993676
140neutrophil activation (GO:0042119)3.16143452
141type I interferon signaling pathway (GO:0060337)3.15993077
142cellular response to type I interferon (GO:0071357)3.15993077
143renal filtration (GO:0097205)3.15509260
144positive regulation of interferon-beta production (GO:0032728)3.15236350
145positive regulation of epidermis development (GO:0045684)3.15011015
146positive regulation of natural killer cell activation (GO:0032816)3.14549581
147fatty acid elongation (GO:0030497)3.13168532
148axon development (GO:0061564)3.12026949
149response to muramyl dipeptide (GO:0032495)3.11968442
150chemical homeostasis within a tissue (GO:0048875)3.11307018
151growth hormone receptor signaling pathway (GO:0060396)3.10695123
152response to type I interferon (GO:0034340)3.10253757
153positive regulation of antigen processing and presentation (GO:0002579)3.08046057
154negative regulation of T cell differentiation in thymus (GO:0033085)3.07771777
155myeloid dendritic cell differentiation (GO:0043011)3.07704551
156regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.07396555
157regulation of chemokine biosynthetic process (GO:0045073)3.06630855
158positive regulation of cytokine biosynthetic process (GO:0042108)3.05546111
159granulocyte activation (GO:0036230)3.05406677
160negative regulation of interleukin-10 production (GO:0032693)3.04973378
161positive regulation of tissue remodeling (GO:0034105)3.04956881
162hydrogen peroxide biosynthetic process (GO:0050665)3.04741321
163cellular response to interferon-gamma (GO:0071346)3.04211656
164regulation of T-helper 1 cell differentiation (GO:0045625)3.03698485
165monocyte chemotaxis (GO:0002548)3.02539215
166regulation of cellular extravasation (GO:0002691)3.01905541
167epidermis development (GO:0008544)2.99928069
168positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.97675899
169tissue regeneration (GO:0042246)2.90820373
170positive regulation of cholesterol efflux (GO:0010875)2.89331221
171angiotensin maturation (GO:0002003)2.88749420
172epidermal cell differentiation (GO:0009913)2.88621256
173one-carbon compound transport (GO:0019755)2.87433829
174keratinocyte development (GO:0003334)2.81790598
175positive regulation of sterol transport (GO:0032373)2.78391272
176positive regulation of cholesterol transport (GO:0032376)2.78391272
177keratan sulfate catabolic process (GO:0042340)2.75925463
178regulation of clathrin-mediated endocytosis (GO:2000369)2.75508426
179tissue homeostasis (GO:0001894)2.75375205
180hair follicle morphogenesis (GO:0031069)2.71931763
181primary alcohol metabolic process (GO:0034308)2.69022113
182cellular response to growth hormone stimulus (GO:0071378)2.67517975
183maintenance of gastrointestinal epithelium (GO:0030277)2.65208274
184negative regulation of granulocyte differentiation (GO:0030853)2.63756707
185lung lobe morphogenesis (GO:0060463)2.60168468
186digestive system process (GO:0022600)2.59628365
187regulation of epidermal cell differentiation (GO:0045604)2.59590633
188hemidesmosome assembly (GO:0031581)2.56580870
189regulation of lymphocyte migration (GO:2000401)2.55742491
190Rap protein signal transduction (GO:0032486)2.52753983
191intermediate filament cytoskeleton organization (GO:0045104)2.52308920
192negative regulation of cell-substrate adhesion (GO:0010812)2.50075181
193negative regulation of keratinocyte proliferation (GO:0010839)2.49475666
194carnitine metabolic process (GO:0009437)2.48843140
195epithelial structure maintenance (GO:0010669)2.44471141
196face development (GO:0060324)2.42211217
197intermediate filament-based process (GO:0045103)2.41754618
198biomineral tissue development (GO:0031214)2.38419298

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse7.86288052
2IRF8_22096565_ChIP-ChIP_GC-B_Human7.68147934
3ESR1_20079471_ChIP-ChIP_T-47D_Human6.57848674
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.29708776
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.61668773
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.61486911
7IRF8_27001747_Chip-Seq_BMDM_Mouse4.57407162
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.33360959
9ESR1_21235772_ChIP-Seq_MCF-7_Human3.93065287
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.90264419
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.71583193
12RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.67785224
13ESR2_21235772_ChIP-Seq_MCF-7_Human3.52155523
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.45654975
15* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.28231777
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.16274607
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.10267063
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.08920586
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.88380081
20ZNF217_24962896_ChIP-Seq_MCF-7_Human2.71772507
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.67840841
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.44677806
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.34792929
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.31134206
25TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.26855901
26SMAD_19615063_ChIP-ChIP_OVARY_Human2.20461262
27CLOCK_20551151_ChIP-Seq_293T_Human2.18145391
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.14154363
29FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.01526784
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.90850571
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.90075151
32GATA3_24758297_ChIP-Seq_MCF-7_Human1.88912834
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.81154707
34VDR_24787735_ChIP-Seq_THP-1_Human1.80934770
35RUNX_20019798_ChIP-Seq_JUKART_Human1.80710996
36FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.79684239
37TP63_17297297_ChIP-ChIP_HaCaT_Human1.76418506
38FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.76212002
39* RUNX1_27514584_Chip-Seq_MCF-7_Human1.74926491
40FOXO3_23340844_ChIP-Seq_DLD1_Human1.74859834
41ZNF263_19887448_ChIP-Seq_K562_Human1.73827147
42SOX9_24532713_ChIP-Seq_HFSC_Mouse1.71714847
43P63_26484246_Chip-Seq_KERATINOCYTES_Human1.71109354
44EGR1_19374776_ChIP-ChIP_THP-1_Human1.71032075
45RACK7_27058665_Chip-Seq_MCF-7_Human1.70706605
46SOX2_27498859_Chip-Seq_STOMACH_Mouse1.70587371
47PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.69130508
48ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.68751143
49AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.65860916
50PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.64454441
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.63925959
52AHR_22903824_ChIP-Seq_MCF-7_Human1.63653263
53MYB_26560356_Chip-Seq_TH2_Human1.58787647
54SPI1_23547873_ChIP-Seq_NB4_Human1.58320529
55BRD4_27068464_Chip-Seq_AML-cells_Mouse1.56966186
56NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.56826927
57CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.56813267
58PU_27001747_Chip-Seq_BMDM_Mouse1.51994239
59SPI1_23127762_ChIP-Seq_K562_Human1.51127839
60* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.50504070
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.47349318
62GATA4_25053715_ChIP-Seq_YYC3_Human1.46924322
63CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44915971
64PPAR_26484153_Chip-Seq_NCI-H1993_Human1.44481355
65VDR_24763502_ChIP-Seq_THP-1_Human1.41219666
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.39181987
67AR_21909140_ChIP-Seq_LNCAP_Human1.38492562
68ELF5_23300383_ChIP-Seq_T47D_Human1.33624017
69NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.32023720
70CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30692661
71KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30583407
72PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.29690615
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.28240790
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27667236
75RXR_22108803_ChIP-Seq_LS180_Human1.24757602
76CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22161393
77MAF_26560356_Chip-Seq_TH1_Human1.21778368
78* GATA3_26560356_Chip-Seq_TH2_Human1.20024487
79PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19809131
80PPARA_22158963_ChIP-Seq_LIVER_Mouse1.16729562
81TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15609940
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15252231
83RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.13007353
84NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12687274
85NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12687274
86FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.10143011
87FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.09000911
88ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08931064
89FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.07849861
90FOXA1_25552417_ChIP-Seq_VCAP_Human1.07681319
91GATA2_21666600_ChIP-Seq_HMVEC_Human1.07371289
92ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06536928
93SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05257981
94LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04817589
95TCF4_18268006_ChIP-ChIP_LS174T_Human1.04429118
96BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.04240776
97TRIM28_21343339_ChIP-Seq_HEK293_Human1.04111500
98NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.04030632
99SOX2_20726797_ChIP-Seq_SW620_Human1.03889050
100PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03852228
101RUNX1_22412390_ChIP-Seq_EML_Mouse1.03480315
102CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02966533
103GATA3_27048872_Chip-Seq_THYMUS_Human1.01757211
104GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01463192
105RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.00962966
106PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00870241
107WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00869263
108EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00867267
109TBX20_22328084_ChIP-Seq_HEART_Mouse1.00511595
110TBX20_22080862_ChIP-Seq_HEART_Mouse1.00511595
111IKZF1_21737484_ChIP-ChIP_HCT116_Human1.00361431
112KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00279092
113GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99554163
114* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98651108
115BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98620661
116LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.96806707
117GATA6_25053715_ChIP-Seq_YYC3_Human0.95019607
118MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.94319449
119RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93214667
120HIF1A_21447827_ChIP-Seq_MCF-7_Human0.92545682
121MYB_26560356_Chip-Seq_TH1_Human0.91507808
122ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90705730
123CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.86857470
124CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.86168300
125TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83247062
126SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.83241634
127STAT6_21828071_ChIP-Seq_BEAS2B_Human0.82842373
128TP53_18474530_ChIP-ChIP_U2OS_Human0.81256781
129FOXA2_19822575_ChIP-Seq_HepG2_Human0.81033824
130SCL_19346495_ChIP-Seq_HPC-7_Human0.78864814
131EGR1_19032775_ChIP-ChIP_M12_Human0.78776941
132FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.78549806
133TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77447327
134ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.76799249
135KLF5_25053715_ChIP-Seq_YYC3_Human0.74162601
136TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.72725211
137CREB1_26743006_Chip-Seq_LNCaP_Human0.71683373
138UBF1/2_26484160_Chip-Seq_HMECs_Human0.70251621
139SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.69096034
140SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.69096034
141CDX2_20551321_ChIP-Seq_CACO-2_Human0.67854019
142ESR1_15608294_ChIP-ChIP_MCF-7_Human0.67828864
143SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.67616133
144ELK3_25401928_ChIP-Seq_HUVEC_Human0.66642979
145CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.65998302
146TCF7_22412390_ChIP-Seq_EML_Mouse0.65533769
147P300_27058665_Chip-Seq_ZR-75-30cells_Human0.64852000
148RXR_22158963_ChIP-Seq_LIVER_Mouse0.63412828
149ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.62575696
150ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.61966706
151GATA1_19941827_ChIP-Seq_MEL_Mouse0.61311778
152CJUN_26792858_Chip-Seq_BT549_Human0.58291523
153LXR_22158963_ChIP-Seq_LIVER_Mouse0.58065647
154JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.58040872
155GATA2_22383799_ChIP-Seq_G1ME_Mouse0.55439799
156VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.54010558
157JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.53385189
158SALL4_18804426_ChIP-ChIP_XEN_Mouse0.52681891
159CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.52654681
160CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.51891763
161GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.51700266
162NR3C1_23031785_ChIP-Seq_PC12_Mouse0.51532687
163KAP1_22055183_ChIP-Seq_ESCs_Mouse0.51096817
164ZFP57_27257070_Chip-Seq_ESCs_Mouse0.51096097
165TP63_23658742_ChIP-Seq_EP156T_Human0.51060068
166ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.50521372

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005275_abnormal_skin_tensile6.57399409
2MP0001835_abnormal_antigen_presentation5.37036249
3MP0002796_impaired_skin_barrier5.12601746
4MP0009785_altered_susceptibility_to5.05832576
5MP0002148_abnormal_hypersensitivity_rea4.51736629
6MP0003183_abnormal_peptide_metabolism4.51249434
7MP0005671_abnormal_response_to4.03800408
8MP0003436_decreased_susceptibility_to3.71845154
9MP0010234_abnormal_vibrissa_follicle3.71786133
10MP0004510_myositis3.37093988
11MP0005025_abnormal_response_to3.30110690
12MP0005000_abnormal_immune_tolerance3.23473404
13MP0000685_abnormal_immune_system3.19884484
14MP0002419_abnormal_innate_immunity3.11605951
15MP0006082_CNS_inflammation3.10041090
16MP0005503_abnormal_tendon_morphology2.93181842
17MP0002098_abnormal_vibrissa_morphology2.82881829
18MP0002009_preneoplasia2.81154933
19MP0003724_increased_susceptibility_to2.65578498
20MP0001853_heart_inflammation2.63995698
21MP0002452_abnormal_antigen_presenting2.52464134
22MP0005501_abnormal_skin_physiology2.51901517
23MP0005387_immune_system_phenotype2.51519906
24MP0001790_abnormal_immune_system2.51519906
25MP0001800_abnormal_humoral_immune2.50201568
26MP0004264_abnormal_extraembryonic_tissu2.42718831
27MP0002060_abnormal_skin_morphology2.38414354
28MP0002723_abnormal_immune_serum2.37266103
29MP0005310_abnormal_salivary_gland2.25906575
30MP0005167_abnormal_blood-brain_barrier2.22491503
31MP0009764_decreased_sensitivity_to2.18313645
32MP0000647_abnormal_sebaceous_gland2.15178248
33MP0009780_abnormal_chondrocyte_physiolo2.11270797
34MP0003690_abnormal_glial_cell2.10713483
35MP0003303_peritoneal_inflammation2.09635048
36MP0001819_abnormal_immune_cell2.08503443
37MP0002138_abnormal_hepatobiliary_system2.08259266
38MP0008438_abnormal_cutaneous_collagen2.05006183
39MP0000579_abnormal_nail_morphology2.04955701
40MP0002420_abnormal_adaptive_immunity2.03019757
41MP0002006_tumorigenesis2.01561914
42MP0003075_altered_response_to2.01223310
43MP0005670_abnormal_white_adipose2.00847602
44MP0009333_abnormal_splenocyte_physiolog1.99343580
45MP0004381_abnormal_hair_follicle1.96638518
46MP0000377_abnormal_hair_follicle1.89768806
47MP0001348_abnormal_lacrimal_gland1.89476031
48MP0003448_altered_tumor_morphology1.89330444
49MP0003279_aneurysm1.89235504
50MP0010155_abnormal_intestine_physiology1.89106375
51MP0000467_abnormal_esophagus_morphology1.87755004
52MP0002254_reproductive_system_inflammat1.86742074
53MP0001845_abnormal_inflammatory_respons1.86079246
54MP0001533_abnormal_skeleton_physiology1.85764127
55MP0001216_abnormal_epidermal_layer1.82173129
56MP0002405_respiratory_system_inflammati1.79882045
57MP0008469_abnormal_protein_level1.71757136
58MP0005166_decreased_susceptibility_to1.67449806
59MP0002108_abnormal_muscle_morphology1.64632963
60MP0003453_abnormal_keratinocyte_physiol1.58027669
61MP0000604_amyloidosis1.53143348
62MP0004947_skin_inflammation1.48687322
63MP0000569_abnormal_digit_pigmentation1.48231245
64MP0010678_abnormal_skin_adnexa1.43549022
65MP0000858_altered_metastatic_potential1.41245870
66MP0002876_abnormal_thyroid_physiology1.40934802
67MP0010771_integument_phenotype1.39823604
68MP0000343_altered_response_to1.37845349
69MP0003828_pulmonary_edema1.36739511
70MP0009763_increased_sensitivity_to1.35703491
71MP0002282_abnormal_trachea_morphology1.33142967
72MP0000716_abnormal_immune_system1.32642839
73MP0004036_abnormal_muscle_relaxation1.29578848
74MP0002166_altered_tumor_susceptibility1.27991529
75MP0005164_abnormal_response_to1.26208855
76MP0006138_congestive_heart_failure1.23950396
77MP0005464_abnormal_platelet_physiology1.23684919
78MP0005397_hematopoietic_system_phenotyp1.23677320
79MP0001545_abnormal_hematopoietic_system1.23677320
80MP0003705_abnormal_hypodermis_morpholog1.21545419
81MP0002398_abnormal_bone_marrow1.19094908
82MP0004084_abnormal_cardiac_muscle1.18985683
83MP0000678_abnormal_parathyroid_gland1.16924355
84MP0002998_abnormal_bone_remodeling1.16504398
85MP0000383_abnormal_hair_follicle1.10716903
86MP0001243_abnormal_dermal_layer1.09928298
87MP0004043_abnormal_pH_regulation1.08456025
88MP0002877_abnormal_melanocyte_morpholog1.07583209
89MP0002163_abnormal_gland_morphology1.06153674
90MP0009931_abnormal_skin_appearance1.05271168
91MP0000767_abnormal_smooth_muscle1.03935020
92MP0009765_abnormal_xenobiotic_induced1.02905285
93MP0000367_abnormal_coat/_hair1.02801142
94MP0003941_abnormal_skin_development1.02604518
95MP0004883_abnormal_blood_vessel1.02563543
96MP0005666_abnormal_adipose_tissue1.02211196
97MP0001346_abnormal_lacrimal_gland0.98133177
98MP0000689_abnormal_spleen_morphology0.97812255
99MP0005248_abnormal_Harderian_gland0.96331112
100MP0003191_abnormal_cellular_cholesterol0.96170952
101MP0005508_abnormal_skeleton_morphology0.95943919
102MP0002429_abnormal_blood_cell0.92889654
103MP0003329_amyloid_beta_deposits0.92882154
104MP0010386_abnormal_urinary_bladder0.92174561
105MP0002722_abnormal_immune_system0.88966700
106MP0001958_emphysema0.88954122
107MP0000566_synostosis0.88448706
108MP0003868_abnormal_feces_composition0.87206844
109MP0001542_abnormal_bone_strength0.86714279
110MP0000762_abnormal_tongue_morphology0.85661870
111MP0002933_joint_inflammation0.84390111
112MP0004019_abnormal_vitamin_homeostasis0.84367266
113MP0005023_abnormal_wound_healing0.83797051
114MP0005647_abnormal_sex_gland0.82295592
115MP0010307_abnormal_tumor_latency0.81778328
116MP0000249_abnormal_blood_vessel0.81586035
117MP0005390_skeleton_phenotype0.81432262
118MP0003638_abnormal_response/metabolism_0.80605089
119MP0005451_abnormal_body_composition0.80563130
120MP0004885_abnormal_endolymph0.80399657
121MP0003186_abnormal_redox_activity0.78877851
122MP0000427_abnormal_hair_cycle0.78010811
123MP0000613_abnormal_salivary_gland0.77876337
124MP0001727_abnormal_embryo_implantation0.77373359
125MP0003300_gastrointestinal_ulcer0.76222734
126MP0000751_myopathy0.75620907
127MP0002938_white_spotting0.75080094
128MP0005058_abnormal_lysosome_morphology0.74244944
129MP0000920_abnormal_myelination0.73070415
130MP0000750_abnormal_muscle_regeneration0.72316741
131MP0002896_abnormal_bone_mineralization0.72218654
132MP0000465_gastrointestinal_hemorrhage0.71695053
133MP0002295_abnormal_pulmonary_circulatio0.69850646
134MP0003938_abnormal_ear_development0.68596535
135MP0000627_abnormal_mammary_gland0.67999874
136MP0002136_abnormal_kidney_physiology0.67860774
137MP0001756_abnormal_urination0.67577843
138MP0003091_abnormal_cell_migration0.67186134
139MP0005375_adipose_tissue_phenotype0.67017390
140MP0003866_abnormal_defecation0.66382677
141MP0008004_abnormal_stomach_pH0.65916482
142MP0004782_abnormal_surfactant_physiolog0.64245253
143MP0005409_darkened_coat_color0.63535561
144MP0008057_abnormal_DNA_replication0.63124494
145MP0001851_eye_inflammation0.63040198
146MP0002127_abnormal_cardiovascular_syste0.62533897
147MP0005076_abnormal_cell_differentiation0.60475238
148MP0001879_abnormal_lymphatic_vessel0.59197614
149MP0003936_abnormal_reproductive_system0.59119290
150MP0009379_abnormal_foot_pigmentation0.58873605
151MP0001191_abnormal_skin_condition0.57963643
152MP0002693_abnormal_pancreas_physiology0.57301195
153MP0001340_abnormal_eyelid_morphology0.56211047
154MP0003252_abnormal_bile_duct0.55802873
155MP0005330_cardiomyopathy0.55474625
156MP0001881_abnormal_mammary_gland0.55392696
157MP0005408_hypopigmentation0.54917316
158MP0005171_absent_coat_pigmentation0.54846597
159MP0003566_abnormal_cell_adhesion0.54593565
160MP0003045_fibrosis0.54113005
161MP0002168_other_aberrant_phenotype0.53462600
162MP0003656_abnormal_erythrocyte_physiolo0.53422616
163MP0000470_abnormal_stomach_morphology0.52694753
164MP0003633_abnormal_nervous_system0.51439806
165MP0003763_abnormal_thymus_physiology0.49607796
166MP0009840_abnormal_foam_cell0.48656285
167MP0004130_abnormal_muscle_cell0.48464137
168MP0002277_abnormal_respiratory_mucosa0.48435502
169MP0000371_diluted_coat_color0.47247256
170MP0003795_abnormal_bone_structure0.45153790
171MP0009278_abnormal_bone_marrow0.44337332
172MP0003631_nervous_system_phenotype0.43755676
173MP0008874_decreased_physiological_sensi0.43440363
174MP0005083_abnormal_biliary_tract0.41783976

Predicted human phenotypes

RankGene SetZ-score
1Gastrointestinal infarctions (HP:0005244)7.68122411
2Systemic lupus erythematosus (HP:0002725)7.08039248
3Recurrent abscess formation (HP:0002722)6.84581018
4Recurrent bacterial skin infections (HP:0005406)6.69617930
5Abnormality of nail color (HP:0100643)6.44961567
6Eczematoid dermatitis (HP:0000976)5.99418722
7Recurrent gram-negative bacterial infections (HP:0005420)5.88281526
8Woolly hair (HP:0002224)5.71339595
9Elevated erythrocyte sedimentation rate (HP:0003565)5.50754431
10Right ventricular cardiomyopathy (HP:0011663)5.45025276
11Hypotrichosis (HP:0001006)5.16272090
12Pili torti (HP:0003777)5.03595635
13Increased IgE level (HP:0003212)4.98017595
14Mediastinal lymphadenopathy (HP:0100721)4.79751362
15Congenital ichthyosiform erythroderma (HP:0007431)4.49286986
16Vasculitis (HP:0002633)4.46414397
17Lip pit (HP:0100267)4.43678288
18Breast carcinoma (HP:0003002)4.35578053
19Increased IgM level (HP:0003496)4.33414337
20Recurrent skin infections (HP:0001581)4.22485497
21Retrobulbar optic neuritis (HP:0100654)4.16089183
22Optic neuritis (HP:0100653)4.16089183
23Onycholysis (HP:0001806)4.13500502
24Abnormality of secondary sexual hair (HP:0009888)4.12459025
25Abnormality of the axillary hair (HP:0100134)4.12459025
26Petechiae (HP:0000967)4.12357760
27Alopecia of scalp (HP:0002293)4.03959818
28Pulmonary artery stenosis (HP:0004415)4.01721037
29Gingivitis (HP:0000230)3.87360668
30Orchitis (HP:0100796)3.84464619
31Myositis (HP:0100614)3.72591000
32Slow-growing hair (HP:0002217)3.72000663
33Abnormality of hair growth rate (HP:0011363)3.72000663
34Thick nail (HP:0001805)3.66532901
35Abnormality of complement system (HP:0005339)3.61380664
36Pustule (HP:0200039)3.59922594
37Basal ganglia calcification (HP:0002135)3.57535812
38Palmoplantar hyperkeratosis (HP:0000972)3.53553607
39Follicular hyperkeratosis (HP:0007502)3.50509022
40Amaurosis fugax (HP:0100576)3.47684707
41Hemoptysis (HP:0002105)3.46467558
42Ependymoma (HP:0002888)3.44861502
43Purpura (HP:0000979)3.42024631
44Hypertensive crisis (HP:0100735)3.38703891
45Brittle hair (HP:0002299)3.32697671
46Recurrent fungal infections (HP:0002841)3.29002628
47Gangrene (HP:0100758)3.28794245
48Stomach cancer (HP:0012126)3.28409990
49Palmar hyperkeratosis (HP:0010765)3.27886381
50Abnormal hair laboratory examination (HP:0003328)3.24426163
51Erythroderma (HP:0001019)3.22590484
52Anorexia (HP:0002039)3.20141868
53Periodontitis (HP:0000704)3.19322906
54Interstitial pulmonary disease (HP:0006530)3.18347294
55Vascular tortuosity (HP:0004948)3.17956079
56Hypokinesia (HP:0002375)3.17656278
57Abnormality of macrophages (HP:0004311)3.16630829
58Chest pain (HP:0100749)3.10691418
59Poor head control (HP:0002421)3.03779409
60Erythema (HP:0010783)3.03458191
61Plantar hyperkeratosis (HP:0007556)3.01162600
62Glomerulonephritis (HP:0000099)3.00466640
63Oral leukoplakia (HP:0002745)3.00255732
64Pulmonary infiltrates (HP:0002113)2.99985190
65Prolonged neonatal jaundice (HP:0006579)2.95986728
66Recurrent viral infections (HP:0004429)2.94497648
67Stomatitis (HP:0010280)2.92882522
68Hypergammaglobulinemia (HP:0010702)2.90649217
69Recurrent bronchitis (HP:0002837)2.89311052
70Abnormality of glycolipid metabolism (HP:0010969)2.88529104
71Abnormality of liposaccharide metabolism (HP:0010968)2.88529104
72Abnormality of glycosphingolipid metabolism (HP:0004343)2.88529104
73Autoimmune thrombocytopenia (HP:0001973)2.85013398
74Arterial tortuosity (HP:0005116)2.84901669
75Chronic mucocutaneous candidiasis (HP:0002728)2.84111053
76Recurrent cutaneous fungal infections (HP:0011370)2.84111053
77Aortic aneurysm (HP:0004942)2.81292227
78Nail dystrophy (HP:0008404)2.79569754
79Nephritis (HP:0000123)2.78851188
80Axonal loss (HP:0003447)2.74368268
81Porencephaly (HP:0002132)2.74148384
82Arterial thrombosis (HP:0004420)2.74061720
83Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.73806695
84Spontaneous abortion (HP:0005268)2.72654471
85Abnormal cartilage morphology (HP:0002763)2.71074335
86Abnormality of the pericardium (HP:0001697)2.69490955
87Sparse lateral eyebrow (HP:0005338)2.67318216
88Lower limb hyperreflexia (HP:0002395)2.64047414
89Keratoconjunctivitis sicca (HP:0001097)2.61710917
90Chronic obstructive pulmonary disease (HP:0006510)2.60050464
91Obstructive lung disease (HP:0006536)2.60050464
92Abnormality of permanent molar morphology (HP:0011071)2.53820818
93Abnormality of the dental root (HP:0006486)2.53820818
94Taurodontia (HP:0000679)2.53820818
95Pigmentary retinal degeneration (HP:0001146)2.53140721
96Recurrent pneumonia (HP:0006532)2.52859121
97Vacuolated lymphocytes (HP:0001922)2.50808871
98Peritonitis (HP:0002586)2.48672310
99Hemorrhage of the eye (HP:0011885)2.48104132
100Joint swelling (HP:0001386)2.47976834
101Absent eyelashes (HP:0000561)2.47531911
102Ectropion (HP:0000656)2.45144960
103Cellulitis (HP:0100658)2.45129863
104Osteolytic defects of the hand bones (HP:0009699)2.44709030
105Osteolytic defects of the phalanges of the hand (HP:0009771)2.44709030
106Abnormality of molar (HP:0011077)2.43748929
107Abnormality of molar morphology (HP:0011070)2.43748929
108Sparse eyelashes (HP:0000653)2.43267966
109Gingival bleeding (HP:0000225)2.43255489
110Distal lower limb muscle weakness (HP:0009053)2.40098010
111Conjunctival hamartoma (HP:0100780)2.39436426
112Keratoconjunctivitis (HP:0001096)2.39356505
113Abnormality of the dental pulp (HP:0006479)2.37960906
114Vertebral compression fractures (HP:0002953)2.37590414
115Arthralgia (HP:0002829)2.37298159
116Chronic sinusitis (HP:0011109)2.37050994
117Cerebral ischemia (HP:0002637)2.37016102
118Tetraparesis (HP:0002273)2.33563000
119Abnormality of the pleura (HP:0002103)2.33180951
120Urticaria (HP:0001025)2.33132745
121Aplasia cutis congenita (HP:0001057)2.32420412
122Meningitis (HP:0001287)2.30658735
123Mitral stenosis (HP:0001718)2.29904385
124Autoamputation (HP:0001218)2.27556700
125Absent hair (HP:0002298)2.25251694
126Aortic dissection (HP:0002647)2.24511762
127Leukocytosis (HP:0001974)2.24215563
128Myocardial infarction (HP:0001658)2.21306258
129Alveolar cell carcinoma (HP:0006519)2.19954132
130Hypohidrosis (HP:0000966)2.17690978
131Bronchitis (HP:0012387)2.16964071
132Premature loss of primary teeth (HP:0006323)2.16820844
133Recurrent lower respiratory tract infections (HP:0002783)2.16141428
134Frequent falls (HP:0002359)2.14370270
135Skin ulcer (HP:0200042)2.13806958
136Astrocytoma (HP:0009592)2.13649146
137Abnormality of the astrocytes (HP:0100707)2.13649146
138Acanthosis nigricans (HP:0000956)2.13188753
139Abnormality of T cell number (HP:0011839)2.11684524
140Palmoplantar keratoderma (HP:0000982)2.11408374
141Increased connective tissue (HP:0009025)2.10832885
142Cerebral aneurysm (HP:0004944)2.10520952
143Neoplasm of the tracheobronchial system (HP:0100552)2.10173631
144Disinhibition (HP:0000734)2.07404585
145Hyporeflexia of lower limbs (HP:0002600)2.07385230
146Corneal erosion (HP:0200020)2.05460124
147Villous atrophy (HP:0011473)2.04784262
148Abnormality of small intestinal villus morphology (HP:0011472)2.04784262
149Complement deficiency (HP:0004431)2.04777708
150Germ cell neoplasia (HP:0100728)2.04566724
151Deep philtrum (HP:0002002)2.03775839
152Natal tooth (HP:0000695)2.03736093
153Abnormality of the endocardium (HP:0004306)2.03703920
154Congenital, generalized hypertrichosis (HP:0004540)2.02927884
155Severe Myopia (HP:0011003)2.02854660
156Progressive visual loss (HP:0000529)2.01975863
157Congenital sensorineural hearing impairment (HP:0008527)2.00771706
158Abnormality of the basal ganglia (HP:0002134)2.00365759
159Autoimmune hemolytic anemia (HP:0001890)1.99997966
160Bulbar palsy (HP:0001283)1.98625449
161Hyperactive renin-angiotensin system (HP:0000841)1.97561989
162Dehydration (HP:0001944)1.97512359
163Hematochezia (HP:0002573)1.96378303
164Amyloidosis (HP:0011034)1.95300214
165Increased neuronal autofluorescent lipopigment (HP:0002074)1.95260933
166Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.95167090
167Nasal speech (HP:0001611)1.94890559
168Chondrocalcinosis (HP:0000934)1.93637307
169Chronic otitis media (HP:0000389)1.92563673
170Obstructive sleep apnea (HP:0002870)1.91316223
171Osteomyelitis (HP:0002754)1.90888000
172Cleft eyelid (HP:0000625)1.89744249
173Prostate neoplasm (HP:0100787)1.89672436
174Acrocyanosis (HP:0001063)1.89527831
175Abnormal blistering of the skin (HP:0008066)1.88607676
176Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.87029684
177Hamartoma of the eye (HP:0010568)1.86874609
178Heterochromia iridis (HP:0001100)1.86517383
179Abnormality of Sharpey fibers (HP:0100685)1.85844686
180Advanced eruption of teeth (HP:0006288)1.85419031
181Hepatosplenomegaly (HP:0001433)1.85007860
182Fine hair (HP:0002213)1.84811435
183Cerebral hemorrhage (HP:0001342)1.84811154
184Bilateral sensorineural hearing impairment (HP:0008619)1.84787646
185Thin bony cortex (HP:0002753)1.83616887
186Seborrheic dermatitis (HP:0001051)1.81803584
187Sparse scalp hair (HP:0002209)1.78960827
188Ulnar claw (HP:0001178)1.78747751
189Segmental peripheral demyelination/remyelination (HP:0003481)1.78216091
190Milia (HP:0001056)1.75495022
191Parakeratosis (HP:0001036)1.73489026
192Hypoplasia of the iris (HP:0007676)1.73377952

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK5.81343365
2MAP3K144.96194798
3EPHA24.83694345
4RIPK44.16240444
5PIM24.01738710
6TBK13.59349898
7BRSK23.35978417
8TYK23.20556284
9NEK93.04496638
10IKBKB2.94399801
11RIPK12.92123623
12PBK2.85218120
13JAK32.60359107
14IRAK42.49747429
15FER2.25717533
16STK38L2.24940622
17JAK12.18894034
18PIK3CA2.11866350
19MAP4K12.10572549
20LATS12.10084310
21CHUK2.03095105
22MAPKAPK32.02772357
23IKBKE2.01921383
24TXK1.97263369
25IRAK31.87566803
26ERBB21.76018305
27MAPK151.74023807
28BMPR21.70343941
29PTK21.68063098
30TNK21.66000919
31MYLK1.61532498
32JAK21.49376479
33MAP3K61.44510870
34SIK31.41483916
35CDK121.41395897
36MST1R1.36576707
37ABL21.33288622
38SYK1.26818902
39PRKCI1.25487751
40DMPK1.24237212
41CDK61.24000234
42MAP3K31.20769934
43MST41.18124501
44STK41.17319139
45NME21.12997466
46BTK1.10885753
47ZAP701.09610018
48CLK11.07447788
49TGFBR21.07351368
50CSF1R1.06783303
51MAP3K51.05336913
52KIT1.04889400
53MAP3K131.03173964
54LATS20.98423928
55FES0.97086931
56HCK0.96772281
57LYN0.96445056
58PDGFRA0.94118787
59OXSR10.93670844
60PIM10.92862564
61DAPK30.91793805
62STK240.90869542
63BCR0.90162383
64MAP3K110.89748056
65ERBB30.89679689
66SCYL20.87446607
67FGR0.87183694
68DAPK20.87022524
69CSK0.86217445
70TEC0.85491110
71CASK0.85378817
72ARAF0.84206998
73DDR20.83981347
74CDK70.83824476
75LCK0.83803995
76EEF2K0.83661691
77EIF2AK30.83148744
78TESK10.81950841
79MAP3K40.81630103
80RET0.80427091
81TAOK30.78357691
82MET0.75910859
83MAP3K120.72803639
84EIF2AK20.72558874
85PRKCQ0.69621590
86GRK70.69454543
87SIK20.67779724
88PRKAA20.67143000
89ILK0.66647999
90DYRK1B0.66615200
91MAPK70.66187785
92BMX0.65071500
93YES10.64535957
94PRKCD0.63976190
95PRKD10.63881156
96STK380.63697947
97MARK30.63359621
98ABL10.62535295
99WEE10.61018752
100CAMKK20.59737108
101EPHB10.58865356
102EGFR0.58654903
103RPS6KB20.58174610
104OBSCN0.57270413
105FGFR30.57053732
106EPHA30.56237102
107CDC42BPA0.55716565
108FGFR40.54879914
109BRSK10.54217176
110ADRBK20.53336356
111CDK30.51264358
112TRPM70.50629109
113NUAK10.49217310
114MARK20.48995272
115ICK0.46890966
116TRIB30.45974246
117MTOR0.45811375
118GRK10.45766611
119SIK10.44530498
120PAK40.44456702
121TIE10.43165442
122LRRK20.41779542
123PKN10.41705752
124PIK3CG0.40081780
125RPS6KA20.39063237
126MAP2K60.38310718
127CSNK1E0.37745036
128MAPK30.37687904
129AKT30.37205805
130ROCK10.36787444
131SGK10.36626064
132MAPKAPK20.35714573
133MAPK90.34757845
134MAPK80.34487290
135STK30.34371704
136PKN20.33452639
137STK390.32857410
138ERN10.32474355
139ITK0.32028898
140PAK30.31816349
141DAPK10.31496817
142NTRK10.30513178
143WNK10.27740065
144CAMKK10.26200945
145FYN0.26101501
146SRC0.24652905
147PDK10.24517363
148MAPK40.22578266
149NTRK20.21733185
150PTK60.21179896
151PRKCE0.19220898
152MAP3K80.18392757
153IGF1R0.18293122
154TAOK10.17878265
155PTK2B0.17838822
156PRKCA0.17681184
157PDPK10.16693962
158NEK60.15726115
159PDGFRB0.15655626
160MATK0.15467661

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053304.96225678
2Graft-versus-host disease_Homo sapiens_hsa053324.12526452
3Type I diabetes mellitus_Homo sapiens_hsa049403.83180992
4ABC transporters_Homo sapiens_hsa020103.60841288
5Leishmaniasis_Homo sapiens_hsa051403.14925929
6Staphylococcus aureus infection_Homo sapiens_hsa051503.14058781
7African trypanosomiasis_Homo sapiens_hsa051433.10616297
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.00035528
9Pertussis_Homo sapiens_hsa051332.94404626
10Legionellosis_Homo sapiens_hsa051342.91074342
11Fatty acid biosynthesis_Homo sapiens_hsa000612.77718316
12Toll-like receptor signaling pathway_Homo sapiens_hsa046202.76008937
13Salivary secretion_Homo sapiens_hsa049702.74277595
14Tyrosine metabolism_Homo sapiens_hsa003502.62187250
15Intestinal immune network for IgA production_Homo sapiens_hsa046722.59894749
16Butanoate metabolism_Homo sapiens_hsa006502.48195740
17NF-kappa B signaling pathway_Homo sapiens_hsa040642.41564827
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.20485697
19Malaria_Homo sapiens_hsa051442.20373041
20NOD-like receptor signaling pathway_Homo sapiens_hsa046212.17086248
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.12527979
22Rheumatoid arthritis_Homo sapiens_hsa053232.10928603
23Tuberculosis_Homo sapiens_hsa051522.09095421
24Measles_Homo sapiens_hsa051622.05714148
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.03776934
26Renin secretion_Homo sapiens_hsa049241.98122459
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.92752506
28beta-Alanine metabolism_Homo sapiens_hsa004101.91688594
29Viral myocarditis_Homo sapiens_hsa054161.86479137
30Autoimmune thyroid disease_Homo sapiens_hsa053201.86260542
31Influenza A_Homo sapiens_hsa051641.83804707
32PPAR signaling pathway_Homo sapiens_hsa033201.74030103
33Salmonella infection_Homo sapiens_hsa051321.65522663
34Osteoclast differentiation_Homo sapiens_hsa043801.63947921
35Circadian rhythm_Homo sapiens_hsa047101.62622400
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.61573468
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.55235998
38Toxoplasmosis_Homo sapiens_hsa051451.53968568
39Herpes simplex infection_Homo sapiens_hsa051681.51132552
40TNF signaling pathway_Homo sapiens_hsa046681.47355444
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.46828103
42Phagosome_Homo sapiens_hsa041451.44234496
43Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.43109811
44Chemical carcinogenesis_Homo sapiens_hsa052041.37746192
45Asthma_Homo sapiens_hsa053101.35225836
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.34665017
47Jak-STAT signaling pathway_Homo sapiens_hsa046301.30891980
48Prion diseases_Homo sapiens_hsa050201.29001322
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.28882319
50Estrogen signaling pathway_Homo sapiens_hsa049151.28055842
51Sphingolipid metabolism_Homo sapiens_hsa006001.24755120
52Apoptosis_Homo sapiens_hsa042101.23559806
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.22839556
54Amoebiasis_Homo sapiens_hsa051461.19524258
55Chemokine signaling pathway_Homo sapiens_hsa040621.12925731
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09949286
57ECM-receptor interaction_Homo sapiens_hsa045121.07387561
58Pancreatic secretion_Homo sapiens_hsa049721.06836594
59Arachidonic acid metabolism_Homo sapiens_hsa005901.04582453
60Hematopoietic cell lineage_Homo sapiens_hsa046401.01864112
61Prostate cancer_Homo sapiens_hsa052150.99557880
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.97681097
63Adherens junction_Homo sapiens_hsa045200.94869216
64Shigellosis_Homo sapiens_hsa051310.94855121
65Primary immunodeficiency_Homo sapiens_hsa053400.93680373
66Retinol metabolism_Homo sapiens_hsa008300.90904319
67B cell receptor signaling pathway_Homo sapiens_hsa046620.88692066
68Starch and sucrose metabolism_Homo sapiens_hsa005000.88278083
69Endometrial cancer_Homo sapiens_hsa052130.87218016
70Lysosome_Homo sapiens_hsa041420.82339583
71Focal adhesion_Homo sapiens_hsa045100.81826738
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80224585
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.78135258
74Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77968970
75Cocaine addiction_Homo sapiens_hsa050300.77054055
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76974292
77Tight junction_Homo sapiens_hsa045300.74522159
78Antigen processing and presentation_Homo sapiens_hsa046120.73775158
79Fatty acid degradation_Homo sapiens_hsa000710.72456183
80Amphetamine addiction_Homo sapiens_hsa050310.71072845
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70624694
82AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69616561
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69278238
84Hepatitis B_Homo sapiens_hsa051610.69210410
85Complement and coagulation cascades_Homo sapiens_hsa046100.69156300
86Fatty acid metabolism_Homo sapiens_hsa012120.68933267
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67263798
88Bladder cancer_Homo sapiens_hsa052190.66701167
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65768868
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.64440689
91Notch signaling pathway_Homo sapiens_hsa043300.62065502
92Fatty acid elongation_Homo sapiens_hsa000620.60071221
93Prolactin signaling pathway_Homo sapiens_hsa049170.59171305
94AMPK signaling pathway_Homo sapiens_hsa041520.58972824
95GnRH signaling pathway_Homo sapiens_hsa049120.58658034
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.57161518
97Dorso-ventral axis formation_Homo sapiens_hsa043200.56707698
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56529916
99Peroxisome_Homo sapiens_hsa041460.55926259
100Hepatitis C_Homo sapiens_hsa051600.54492637
101Insulin signaling pathway_Homo sapiens_hsa049100.52332106
102Ovarian steroidogenesis_Homo sapiens_hsa049130.51973240
103Choline metabolism in cancer_Homo sapiens_hsa052310.48796143
104ErbB signaling pathway_Homo sapiens_hsa040120.48715364
105Glutathione metabolism_Homo sapiens_hsa004800.47489128
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46376850
107mTOR signaling pathway_Homo sapiens_hsa041500.44939889
108Phenylalanine metabolism_Homo sapiens_hsa003600.43166936
109cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42024219
110Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40452864
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.40177993
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.39642298
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39634729
114Other glycan degradation_Homo sapiens_hsa005110.39396611
115Steroid biosynthesis_Homo sapiens_hsa001000.39259796
116T cell receptor signaling pathway_Homo sapiens_hsa046600.38406466
117VEGF signaling pathway_Homo sapiens_hsa043700.37959392
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.37380617
119Glucagon signaling pathway_Homo sapiens_hsa049220.36396630
120Renal cell carcinoma_Homo sapiens_hsa052110.36189448
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.34313626
122Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34098929
123Vibrio cholerae infection_Homo sapiens_hsa051100.33226349
124Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32940836
125Dilated cardiomyopathy_Homo sapiens_hsa054140.32277783
126Platelet activation_Homo sapiens_hsa046110.31680659
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31369013
128Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29204092
129HIF-1 signaling pathway_Homo sapiens_hsa040660.28487738
130Epstein-Barr virus infection_Homo sapiens_hsa051690.25478431
131Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24302079
132Tryptophan metabolism_Homo sapiens_hsa003800.24104360
133Chronic myeloid leukemia_Homo sapiens_hsa052200.22120811
134Proteoglycans in cancer_Homo sapiens_hsa052050.17064574
135Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.16506977
136Neurotrophin signaling pathway_Homo sapiens_hsa047220.16348444
137Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.13662551
138Mineral absorption_Homo sapiens_hsa049780.13447343
139Insulin resistance_Homo sapiens_hsa049310.13402296
140Collecting duct acid secretion_Homo sapiens_hsa049660.12953992
141Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.12203392
142Ether lipid metabolism_Homo sapiens_hsa005650.12114975
143Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.11003308
144Acute myeloid leukemia_Homo sapiens_hsa052210.10897175
145Regulation of actin cytoskeleton_Homo sapiens_hsa048100.10611390
146Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.10576235
147Histidine metabolism_Homo sapiens_hsa003400.10270700
148Nitrogen metabolism_Homo sapiens_hsa009100.10188927
149Endocytosis_Homo sapiens_hsa041440.10012073
150MAPK signaling pathway_Homo sapiens_hsa040100.09215219
151Renin-angiotensin system_Homo sapiens_hsa046140.08720208
152HTLV-I infection_Homo sapiens_hsa051660.08681168
153Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.07343253
154Viral carcinogenesis_Homo sapiens_hsa052030.05877936
155Proteasome_Homo sapiens_hsa030500.05772028
156Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.04966536
157Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.03975045
158Small cell lung cancer_Homo sapiens_hsa052220.03441266
159Arginine biosynthesis_Homo sapiens_hsa002200.03424052
160Pancreatic cancer_Homo sapiens_hsa052120.02969178
161Sulfur metabolism_Homo sapiens_hsa009200.02772666
162FoxO signaling pathway_Homo sapiens_hsa04068-0.0077862
163Type II diabetes mellitus_Homo sapiens_hsa04930-0.0005553

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