MUC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axoneme assembly (GO:0035082)8.48182090
2COPI coating of Golgi vesicle (GO:0048205)7.81126976
3Golgi transport vesicle coating (GO:0048200)7.81126976
4left/right pattern formation (GO:0060972)6.88212821
5regulation of cilium movement (GO:0003352)6.25414468
6ventricular system development (GO:0021591)6.16077778
7left/right axis specification (GO:0070986)5.69113824
8diterpenoid biosynthetic process (GO:0016102)5.66576168
9endocrine pancreas development (GO:0031018)5.45495469
10interferon-gamma secretion (GO:0072643)5.34673219
11microtubule bundle formation (GO:0001578)5.33382954
12primary alcohol catabolic process (GO:0034310)5.26286465
13citrulline biosynthetic process (GO:0019240)5.22865343
14maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.21248676
15vitamin transmembrane transport (GO:0035461)5.16617816
16lung epithelium development (GO:0060428)4.98922880
17ethanol metabolic process (GO:0006067)4.90323398
18COPII vesicle coating (GO:0048208)4.87241094
19intestinal epithelial cell development (GO:0060576)4.81675218
20peptide hormone processing (GO:0016486)4.72085613
21protein maturation by protein folding (GO:0022417)4.63699122
22glandular epithelial cell differentiation (GO:0002067)4.58375638
23protein retention in ER lumen (GO:0006621)4.55345790
24retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.55104224
25cilium organization (GO:0044782)4.53229146
26negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.41065320
27hemidesmosome assembly (GO:0031581)4.40763521
28intraciliary transport (GO:0042073)4.34781327
29cilium assembly (GO:0042384)4.33315211
30lung vasculature development (GO:0060426)4.25153662
31bundle of His cell to Purkinje myocyte communication (GO:0086069)4.18124579
32sperm capacitation (GO:0048240)4.14640502
33intestinal absorption (GO:0050892)4.13797897
34one-carbon compound transport (GO:0019755)4.10954676
35keratinization (GO:0031424)4.07780347
36ethanol oxidation (GO:0006069)4.04714531
37columnar/cuboidal epithelial cell development (GO:0002066)4.02622062
38vitamin A metabolic process (GO:0006776)3.97497300
39positive regulation of glycoprotein metabolic process (GO:1903020)3.91298430
40pyrimidine-containing compound transmembrane transport (GO:0072531)3.89056976
41establishment of apical/basal cell polarity (GO:0035089)3.85887459
42microtubule-based movement (GO:0007018)3.85743654
43signal peptide processing (GO:0006465)3.85130078
444-hydroxyproline metabolic process (GO:0019471)3.84699909
45regulation of type B pancreatic cell apoptotic process (GO:2000674)3.83647908
46sequestering of metal ion (GO:0051238)3.81437559
47desmosome organization (GO:0002934)3.68126796
48activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.67746540
49microtubule depolymerization (GO:0007019)3.67343506
50regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.67069790
51positive regulation of osteoblast proliferation (GO:0033690)3.65432511
52regulation of interleukin-5 production (GO:0032674)3.65141879
53decidualization (GO:0046697)3.64545231
54terpenoid biosynthetic process (GO:0016114)3.63033585
55positive regulation of respiratory burst (GO:0060267)3.62520732
56negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.60349233
57vesicle coating (GO:0006901)3.59030264
58keratinocyte differentiation (GO:0030216)3.58377238
59negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.57729560
60regulation of protein glycosylation (GO:0060049)3.57597812
61cellular component assembly involved in morphogenesis (GO:0010927)3.57511069
62retinoic acid metabolic process (GO:0042573)3.57106677
63positive regulation of glycoprotein biosynthetic process (GO:0010560)3.55625126
64negative regulation of T cell differentiation in thymus (GO:0033085)3.50935711
65regulation of microtubule-based movement (GO:0060632)3.50306641
66oligosaccharide biosynthetic process (GO:0009312)3.47348529
67positive regulation of nuclease activity (GO:0032075)3.46819304
68multicellular organismal water homeostasis (GO:0050891)3.44798258
69* protein O-linked glycosylation (GO:0006493)3.44299690
70surfactant homeostasis (GO:0043129)3.42857096
71glomerular epithelial cell development (GO:0072310)3.41227068
72protein localization to cilium (GO:0061512)3.40171127
73regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.37776952
74negative regulation of keratinocyte proliferation (GO:0010839)3.37533272
75establishment of planar polarity (GO:0001736)3.35991065
76establishment of tissue polarity (GO:0007164)3.35991065
77cellular zinc ion homeostasis (GO:0006882)3.35648908
78lung lobe morphogenesis (GO:0060463)3.35411920
79cell projection assembly (GO:0030031)3.34364821
80UDP-N-acetylglucosamine metabolic process (GO:0006047)3.34231852
81centriole assembly (GO:0098534)3.33732172
82sulfate transmembrane transport (GO:1902358)3.33103135
83sodium ion homeostasis (GO:0055078)3.32457471
84endoplasmic reticulum unfolded protein response (GO:0030968)3.30560691
85apical protein localization (GO:0045176)3.27171730
86antibacterial humoral response (GO:0019731)3.26886697
87insulin secretion (GO:0030073)3.25881772
88cellular response to unfolded protein (GO:0034620)3.25006423
89striated muscle atrophy (GO:0014891)3.24308552
90microtubule polymerization or depolymerization (GO:0031109)3.23171974
91antimicrobial humoral response (GO:0019730)3.21243918
92regulation of nuclease activity (GO:0032069)3.20518778
93type B pancreatic cell development (GO:0003323)3.20136446
94negative regulation of humoral immune response (GO:0002921)3.20121911
95regulation of interleukin-13 production (GO:0032656)3.17952105
96establishment of monopolar cell polarity (GO:0061162)3.17685873
97establishment or maintenance of monopolar cell polarity (GO:0061339)3.17685873
98* O-glycan processing (GO:0016266)3.17487279
99regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.17124841
100glandular epithelial cell development (GO:0002068)3.16105262
101excretion (GO:0007588)3.15871083
102phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.15723282
103cytoplasmic microtubule organization (GO:0031122)3.15661463
104exocrine pancreas development (GO:0031017)3.15612521
105regulation of water loss via skin (GO:0033561)3.15567993
106skin morphogenesis (GO:0043589)3.15401814
107hormone catabolic process (GO:0042447)3.13499999
108cellular response to vitamin D (GO:0071305)3.10431552
109negative regulation of bone resorption (GO:0045779)3.09652654
110cellular response to topologically incorrect protein (GO:0035967)3.09246146
111ER-nucleus signaling pathway (GO:0006984)3.07481101
112signal transduction involved in regulation of gene expression (GO:0023019)3.06036898
113ER overload response (GO:0006983)3.05579239
114positive regulation of p38MAPK cascade (GO:1900745)3.04979014
115calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.02933568
116intestinal cholesterol absorption (GO:0030299)3.02815128
117positive regulation of insulin secretion (GO:0032024)3.02440836
1183-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.02037648
119purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.02037648
120lateral ventricle development (GO:0021670)2.97125431
121negative regulation of glycoprotein biosynthetic process (GO:0010561)2.95069541
122tolerance induction (GO:0002507)2.90946210
123skeletal muscle adaptation (GO:0043501)2.90843362
124mucosal immune response (GO:0002385)2.88666007
125negative regulation of immunoglobulin mediated immune response (GO:0002890)2.88351410
126negative regulation of B cell mediated immunity (GO:0002713)2.88351410
127muscle organ morphogenesis (GO:0048644)2.87586989
128tight junction assembly (GO:0070830)2.87391296
129hypotonic response (GO:0006971)2.83755171
130retinal rod cell development (GO:0046548)2.83389209
131water homeostasis (GO:0030104)2.82423481
132membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.80428299
133epidermal cell differentiation (GO:0009913)2.80298280
134regulation of insulin secretion (GO:0050796)2.79966099
135nitric oxide biosynthetic process (GO:0006809)2.79941993
136negative regulation of protein tyrosine kinase activity (GO:0061099)2.79367182
137positive regulation of smoothened signaling pathway (GO:0045880)2.78831907
138response to xenobiotic stimulus (GO:0009410)2.77558117
139peptide catabolic process (GO:0043171)2.76323486
140cilium morphogenesis (GO:0060271)2.74668081
141citrulline metabolic process (GO:0000052)2.73557160
142peptidyl-proline hydroxylation (GO:0019511)2.73509460
143retinol metabolic process (GO:0042572)2.73104742
144response to endoplasmic reticulum stress (GO:0034976)2.71972144
145negative regulation of insulin secretion (GO:0046676)2.71431144
146response to hepatocyte growth factor (GO:0035728)2.70605692
147cellular response to hepatocyte growth factor stimulus (GO:0035729)2.70605692
148establishment or maintenance of apical/basal cell polarity (GO:0035088)2.70528230
149establishment or maintenance of bipolar cell polarity (GO:0061245)2.70528230
150innate immune response in mucosa (GO:0002227)2.70058567
151organ or tissue specific immune response (GO:0002251)2.69575750
152phosphatidylserine acyl-chain remodeling (GO:0036150)2.69280016
153primary alcohol metabolic process (GO:0034308)2.68230080
154protein autoprocessing (GO:0016540)2.67297813
155asymmetric protein localization (GO:0008105)2.65886556
156positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.65618273
157* digestive system process (GO:0022600)2.65585568
158negative regulation of myotube differentiation (GO:0010832)2.64328057
159protein N-linked glycosylation via asparagine (GO:0018279)2.63829608
160muscle atrophy (GO:0014889)2.63689713
161positive regulation of tolerance induction (GO:0002645)2.63191890
162peptidyl-asparagine modification (GO:0018196)2.62618084
163positive regulation of Cdc42 GTPase activity (GO:0043089)2.61450980
164intra-Golgi vesicle-mediated transport (GO:0006891)2.59556503
165ear development (GO:0043583)2.59415754
166toxin metabolic process (GO:0009404)2.58792215
167membrane repolarization during action potential (GO:0086011)2.58716553
168exogenous drug catabolic process (GO:0042738)2.58410546
169embryonic retina morphogenesis in camera-type eye (GO:0060059)2.58310025
170establishment of skin barrier (GO:0061436)2.55450989
171lateral sprouting from an epithelium (GO:0060601)2.53047696
172protein depolymerization (GO:0051261)2.52977824
173regulation of germinal center formation (GO:0002634)2.52467307
174dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.50913945
175cellular anion homeostasis (GO:0030002)2.50534266
176drug catabolic process (GO:0042737)2.50502748
177cytoskeletal anchoring at plasma membrane (GO:0007016)2.49909820
178photoreceptor cell maintenance (GO:0045494)2.46668991
179negative regulation of inclusion body assembly (GO:0090084)2.45081945
180progesterone metabolic process (GO:0042448)2.42711504
181phosphatidylcholine biosynthetic process (GO:0006656)2.42550075
182positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.42144304
183vocalization behavior (GO:0071625)2.41803785
184regulation of respiratory burst (GO:0060263)2.37871276
185DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.33923079
186axonemal dynein complex assembly (GO:0070286)16.3184616
187cilium or flagellum-dependent cell motility (GO:0001539)15.9651924
188cilium movement (GO:0003341)12.7166055
189epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)11.8180709
190motile cilium assembly (GO:0044458)11.7015271
191epithelial cilium movement (GO:0003351)10.2016734

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.39154848
2ESR1_21235772_ChIP-Seq_MCF-7_Human3.85660314
3* SOX2_27498859_Chip-Seq_STOMACH_Mouse3.41743382
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.22618227
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.16871182
6ESR2_21235772_ChIP-Seq_MCF-7_Human2.76460207
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.68742019
8SOX2_20726797_ChIP-Seq_SW620_Human2.67894599
9CDX2_20551321_ChIP-Seq_CACO-2_Human2.67389721
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.59250498
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.37589010
12ZNF217_24962896_ChIP-Seq_MCF-7_Human2.33710091
13GATA4_25053715_ChIP-Seq_YYC3_Human2.33633457
14GATA6_25053715_ChIP-Seq_YYC3_Human2.21753201
15ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.20023800
16FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.17548117
17* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.11795688
18TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.07488923
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.07473439
20STAT6_21828071_ChIP-Seq_BEAS2B_Human2.04825508
21CDX2_19796622_ChIP-Seq_MESCs_Mouse2.01224581
22ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.97121992
23FOXO3_23340844_ChIP-Seq_DLD1_Human1.91085391
24PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.90741028
25RUNX1_27514584_Chip-Seq_MCF-7_Human1.88367428
26GATA1_22025678_ChIP-Seq_K562_Human1.87879180
27PPAR_26484153_Chip-Seq_NCI-H1993_Human1.82123569
28CLOCK_20551151_ChIP-Seq_293T_Human1.81040879
29SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.78912724
30ESR1_20079471_ChIP-ChIP_T-47D_Human1.78685531
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.75874392
32CTNNB1_20460455_ChIP-Seq_HCT116_Human1.73158016
33FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.73043607
34* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.72593005
35* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.70058443
36* SMC4_20622854_ChIP-Seq_HELA_Human1.68583771
37LXR_22158963_ChIP-Seq_LIVER_Mouse1.67685629
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59108847
39ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.54131331
40GATA3_24758297_ChIP-Seq_MCF-7_Human1.53470940
41AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.53316713
42KLF5_25053715_ChIP-Seq_YYC3_Human1.52880305
43BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.50164228
44ESR1_15608294_ChIP-ChIP_MCF-7_Human1.48835573
45ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.45839559
46FOXA1_25552417_ChIP-Seq_VCAP_Human1.45826696
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.44909956
48HIF1A_21447827_ChIP-Seq_MCF-7_Human1.42848533
49* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.42623748
50FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.42275387
51EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41677203
52RACK7_27058665_Chip-Seq_MCF-7_Human1.39386342
53NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.38682760
54CTCF_27219007_Chip-Seq_Bcells_Human1.34923763
55SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.33884271
56SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.33884271
57PPARA_22158963_ChIP-Seq_LIVER_Mouse1.32776436
58* RXR_22158963_ChIP-Seq_LIVER_Mouse1.32598685
59NFIB_24661679_ChIP-Seq_LUNG_Mouse1.30307559
60AHR_22903824_ChIP-Seq_MCF-7_Human1.28275368
61SOX9_24532713_ChIP-Seq_HFSC_Mouse1.27662868
62ATF3_27146783_Chip-Seq_COLON_Human1.27603234
63ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.26954446
64GATA2_21666600_ChIP-Seq_HMVEC_Human1.26877423
65GATA1_19941826_ChIP-Seq_K562_Human1.25368518
66FOXM1_26456572_ChIP-Seq_MCF-7_Human1.23353713
67TCF4_18268006_ChIP-ChIP_LS174T_Human1.22668593
68PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.19961671
69STAT1_20625510_ChIP-Seq_HELA_Human1.19904858
70STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19865135
71TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19729843
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.17600636
73TDRD3_21172665_ChIP-Seq_MCF-7_Human1.15907823
74* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.15125696
75ZNF263_19887448_ChIP-Seq_K562_Human1.11419953
76JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11367424
77FOXA2_19822575_ChIP-Seq_HepG2_Human1.10947115
78WDR5_24793694_ChIP-Seq_LNCAP_Human1.10929757
79CJUN_26792858_Chip-Seq_BT549_Human1.10264684
80ZNF274_21170338_ChIP-Seq_K562_Hela1.09823005
81P68_20966046_ChIP-Seq_HELA_Human1.09452109
82P63_26484246_Chip-Seq_KERATINOCYTES_Human1.08849723
83FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.07663041
84AR_21572438_ChIP-Seq_LNCaP_Human1.05486131
85NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05134670
86ARNT_22903824_ChIP-Seq_MCF-7_Human1.05018092
87ERG_21242973_ChIP-ChIP_JURKAT_Human1.04029241
88HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.03186679
89SMAD3_21741376_ChIP-Seq_HESCs_Human1.02576614
90CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00712810
91PHF8_20622854_ChIP-Seq_HELA_Human0.99690892
92NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.99267348
93TP63_23658742_ChIP-Seq_EP156T_Human0.98749934
94GATA2_19941826_ChIP-Seq_K562_Human0.98416526
95ERG_20517297_ChIP-Seq_VCAP_Human0.98386884
96WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96053824
97E2F1_20622854_ChIP-Seq_HELA_Human0.95469212
98ETV1_20927104_ChIP-Seq_GIST48_Human0.95413886
99TBX20_22328084_ChIP-Seq_HEART_Mouse0.95336775
100TBX20_22080862_ChIP-Seq_HEART_Mouse0.95336775
101EZH2_27294783_Chip-Seq_ESCs_Mouse0.94897858
102CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.94656751
103* LXR_22292898_ChIP-Seq_THP-1_Human0.92582567
104TP53_18474530_ChIP-ChIP_U2OS_Human0.92368530
105CTCF_20526341_ChIP-Seq_ESCs_Human0.91604131
106SMAD4_21741376_ChIP-Seq_HESCs_Human0.91192998
107* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91041202
108GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90845743
109TP53_16413492_ChIP-PET_HCT116_Human0.90706769
110BCAT_22108803_ChIP-Seq_LS180_Human0.90688130
111FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.90218539
112MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.90132274
113AR_19668381_ChIP-Seq_PC3_Human0.88292449
114VDR_22108803_ChIP-Seq_LS180_Human0.88148561
115HNFA_21074721_ChIP-Seq_CACO-2_Human0.88148225
116NFYA_21822215_ChIP-Seq_K562_Human0.88137870
117* CEBPB_22108803_ChIP-Seq_LS180_Human0.86804545
118GATA1_19941827_ChIP-Seq_MEL_Mouse0.86604598
119RAD21_21589869_ChIP-Seq_MESCs_Mouse0.84794685
120VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.84342411
121SALL4_18804426_ChIP-ChIP_XEN_Mouse0.84308357
122* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.83794128
123BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.83422247
124CREB1_26743006_Chip-Seq_LNCaP_Human0.80606573
125PKCTHETA_26484144_Chip-Seq_BREAST_Human0.80545625
126NR3C1_23031785_ChIP-Seq_PC12_Mouse0.80087821
127EP300_21415370_ChIP-Seq_HL-1_Mouse0.79592617
128JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78967890
129KDM2B_26808549_Chip-Seq_K562_Human0.78877372
130SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.78548248
131TP63_22573176_ChIP-Seq_HFKS_Human0.77855660
132NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.75995064
133NRF2_20460467_ChIP-Seq_MEFs_Mouse0.75995064
134ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.74982331
135* DROSHA_22980978_ChIP-Seq_HELA_Human0.73842339
136EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.73770665
137BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.73679333
138CDX2_22108803_ChIP-Seq_LS180_Human0.72754613
139RUNX1_26923725_Chip-Seq_HPCs_Mouse0.72268349
140GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.71613005
141FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.70835310
142OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.70831209

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle7.96449141
2MP0004264_abnormal_extraembryonic_tissu4.67189999
3MP0002653_abnormal_ependyma_morphology4.53725501
4MP0002877_abnormal_melanocyte_morpholog3.62220894
5MP0002909_abnormal_adrenal_gland3.55605906
6MP0005377_hearing/vestibular/ear_phenot3.47942377
7MP0003878_abnormal_ear_physiology3.47942377
8MP0004043_abnormal_pH_regulation3.40279901
9MP0003283_abnormal_digestive_organ3.14388445
10MP0000462_abnormal_digestive_system2.81155680
11MP0002693_abnormal_pancreas_physiology2.79721766
12MP0009780_abnormal_chondrocyte_physiolo2.76884264
13MP0003866_abnormal_defecation2.74768403
14MP0002132_abnormal_respiratory_system2.66721519
15MP0000678_abnormal_parathyroid_gland2.49768705
16MP0002249_abnormal_larynx_morphology2.47862148
17MP0001666_abnormal_nutrient_absorption2.46412880
18MP0000013_abnormal_adipose_tissue2.45392437
19MP0001944_abnormal_pancreas_morphology2.40761908
20MP0002822_catalepsy2.24527964
21MP0006054_spinal_hemorrhage2.24001398
22MP0003300_gastrointestinal_ulcer2.11543090
23MP0010678_abnormal_skin_adnexa2.06691953
24MP0001765_abnormal_ion_homeostasis2.05879038
25MP0005623_abnormal_meninges_morphology2.00588839
26MP0010386_abnormal_urinary_bladder1.99474432
27MP0001984_abnormal_olfaction1.98809598
28MP0002277_abnormal_respiratory_mucosa1.96882194
29MP0005310_abnormal_salivary_gland1.96703911
30MP0004782_abnormal_surfactant_physiolog1.92864715
31MP0003183_abnormal_peptide_metabolism1.91323414
32MP0000465_gastrointestinal_hemorrhage1.88763954
33MP0004133_heterotaxia1.85819037
34MP0001849_ear_inflammation1.83209383
35MP0002098_abnormal_vibrissa_morphology1.76233462
36MP0005220_abnormal_exocrine_pancreas1.68159353
37MP0009643_abnormal_urine_homeostasis1.66868062
38MP0002234_abnormal_pharynx_morphology1.63409454
39MP0003045_fibrosis1.60987380
40MP0002138_abnormal_hepatobiliary_system1.60844787
41MP0002139_abnormal_hepatobiliary_system1.55931869
42MP0008004_abnormal_stomach_pH1.54510110
43MP0005083_abnormal_biliary_tract1.50405317
44MP0001664_abnormal_digestion1.50157029
45MP0008789_abnormal_olfactory_epithelium1.48962628
46MP0004019_abnormal_vitamin_homeostasis1.46963321
47MP0000537_abnormal_urethra_morphology1.41975865
48MP0002078_abnormal_glucose_homeostasis1.40142971
49MP0005379_endocrine/exocrine_gland_phen1.38380279
50MP0002896_abnormal_bone_mineralization1.34453609
51MP0000613_abnormal_salivary_gland1.33554020
52MP0001881_abnormal_mammary_gland1.32174247
53MP0002796_impaired_skin_barrier1.31785549
54MP0004885_abnormal_endolymph1.31174686
55MP0005257_abnormal_intraocular_pressure1.30835669
56MP0005636_abnormal_mineral_homeostasis1.30354972
57MP0001346_abnormal_lacrimal_gland1.27595464
58MP0010352_gastrointestinal_tract_polyps1.27595358
59MP0002254_reproductive_system_inflammat1.27399249
60MP0001348_abnormal_lacrimal_gland1.25774770
61MP0000003_abnormal_adipose_tissue1.23677380
62MP0005409_darkened_coat_color1.21715099
63MP0002876_abnormal_thyroid_physiology1.20756774
64MP0003195_calcinosis1.20560363
65MP0002735_abnormal_chemical_nociception1.17662726
66MP0005248_abnormal_Harderian_gland1.17651773
67MP0003566_abnormal_cell_adhesion1.13222177
68MP0003252_abnormal_bile_duct1.10813754
69MP0000538_abnormal_urinary_bladder1.09945621
70MP0004947_skin_inflammation1.09259581
71MP0006072_abnormal_retinal_apoptosis1.07759361
72MP0005085_abnormal_gallbladder_physiolo1.06169315
73MP0005381_digestive/alimentary_phenotyp1.04087512
74MP0005076_abnormal_cell_differentiation1.03725084
75MP0005670_abnormal_white_adipose1.03623492
76MP0003953_abnormal_hormone_level0.99961757
77MP0003879_abnormal_hair_cell0.97918386
78MP0000477_abnormal_intestine_morphology0.97389611
79MP0002136_abnormal_kidney_physiology0.97224642
80MP0005395_other_phenotype0.96700825
81MP0001216_abnormal_epidermal_layer0.96290499
82MP0005023_abnormal_wound_healing0.95644042
83MP0005365_abnormal_bile_salt0.95368551
84MP0005499_abnormal_olfactory_system0.94571452
85MP0005394_taste/olfaction_phenotype0.94571452
86MP0005187_abnormal_penis_morphology0.94157765
87MP0001873_stomach_inflammation0.93892808
88MP0001756_abnormal_urination0.92070319
89MP0000383_abnormal_hair_follicle0.91622312
90MP0010155_abnormal_intestine_physiology0.91325860
91MP0009046_muscle_twitch0.90287208
92MP0002734_abnormal_mechanical_nocicepti0.90108304
93MP0003453_abnormal_keratinocyte_physiol0.89959929
94MP0004272_abnormal_basement_membrane0.88288637
95MP0003091_abnormal_cell_migration0.86387591
96MP0002928_abnormal_bile_duct0.86099009
97MP0003119_abnormal_digestive_system0.84862939
98MP0004147_increased_porphyrin_level0.82534963
99MP0000470_abnormal_stomach_morphology0.81844510
100MP0002060_abnormal_skin_morphology0.80881200
101MP0005408_hypopigmentation0.80809359
102MP0005503_abnormal_tendon_morphology0.79489697
103MP0005360_urolithiasis0.78803908
104MP0008872_abnormal_physiological_respon0.76981809
105MP0000579_abnormal_nail_morphology0.76892464
106MP0008875_abnormal_xenobiotic_pharmacok0.76061307
107MP0000432_abnormal_head_morphology0.75376292
108MP0000467_abnormal_esophagus_morphology0.74073240
109MP0000627_abnormal_mammary_gland0.73831299
110MP0000026_abnormal_inner_ear0.72724589
111MP0005167_abnormal_blood-brain_barrier0.72529748
112MP0000681_abnormal_thyroid_gland0.72445490
113MP0001270_distended_abdomen0.71490064
114MP0004185_abnormal_adipocyte_glucose0.70538191
115MP0004145_abnormal_muscle_electrophysio0.70472792
116MP0008961_abnormal_basal_metabolism0.69643946
117MP0000427_abnormal_hair_cycle0.69031149
118MP0002089_abnormal_postnatal_growth/wei0.68975345
119MP0002282_abnormal_trachea_morphology0.68083285
120MP0002118_abnormal_lipid_homeostasis0.67491230
121MP0003868_abnormal_feces_composition0.67449792
122MP0005375_adipose_tissue_phenotype0.67050482
123MP0000762_abnormal_tongue_morphology0.67033953
124MP0000566_synostosis0.66356868
125MP0010030_abnormal_orbit_morphology0.65794313
126MP0003705_abnormal_hypodermis_morpholog0.65437494
127MP0001485_abnormal_pinna_reflex0.65003720
128MP0001663_abnormal_digestive_system0.64952989
129MP0002116_abnormal_craniofacial_bone0.64908249
130MP0010368_abnormal_lymphatic_system0.63738412
131MP0002733_abnormal_thermal_nociception0.63652323
132MP0001188_hyperpigmentation0.63516447
133MP0002295_abnormal_pulmonary_circulatio0.63470720
134MP0003950_abnormal_plasma_membrane0.61311559
135MP0001963_abnormal_hearing_physiology0.59959929
136MP0003795_abnormal_bone_structure0.59108306
137MP0003943_abnormal_hepatobiliary_system0.59046391
138MP0002233_abnormal_nose_morphology0.58672119
139MP0010329_abnormal_lipoprotein_level0.58355460
140MP0002837_dystrophic_cardiac_calcinosis0.58220435
141MP0000377_abnormal_hair_follicle0.57885572
142MP0003656_abnormal_erythrocyte_physiolo0.57432159
143MP0001970_abnormal_pain_threshold0.56614394
144MP0005165_increased_susceptibility_to0.56391779
145MP0004270_analgesia0.55643313
146MP0005501_abnormal_skin_physiology0.54765960
147MP0000609_abnormal_liver_physiology0.54632341
148MP0002168_other_aberrant_phenotype0.54011645

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.82122336
2Abnormal respiratory motile cilium morphology (HP:0005938)9.82122336
3Abnormal ciliary motility (HP:0012262)9.60718403
4Abnormal respiratory motile cilium physiology (HP:0012261)9.51466656
5Rhinitis (HP:0012384)8.49169948
6Bronchiectasis (HP:0002110)6.81925463
7Nasal polyposis (HP:0100582)6.30783562
8Hyperinsulinemic hypoglycemia (HP:0000825)5.84888738
9Symptomatic seizures (HP:0011145)5.45808749
10Hypoglycemic seizures (HP:0002173)5.44671100
11Abnormality of the nasal mucosa (HP:0000433)5.36392487
12Elevated circulating parathyroid hormone (PTH) level (HP:0003165)5.02517072
13Hypoglycemic coma (HP:0001325)4.91305736
14Hyperactive renin-angiotensin system (HP:0000841)4.66049327
15Bronchitis (HP:0012387)4.55936835
16Congenital sensorineural hearing impairment (HP:0008527)4.53745918
17Gout (HP:0001997)4.45608517
18Abnormal pancreas size (HP:0012094)4.15750792
19Onycholysis (HP:0001806)4.15214267
20Hyperglycemia (HP:0003074)4.06426567
21Right ventricular cardiomyopathy (HP:0011663)4.04520239
22Decreased circulating renin level (HP:0003351)3.99420335
23Insulin-resistant diabetes mellitus (HP:0000831)3.95768359
24Recurrent sinusitis (HP:0011108)3.93136419
25Hyperparathyroidism (HP:0000843)3.89037223
26Abnormality of small intestinal villus morphology (HP:0011472)3.80805365
27Villous atrophy (HP:0011473)3.80805365
28Recurrent otitis media (HP:0000403)3.77610135
29Male infertility (HP:0003251)3.70432412
30Late onset (HP:0003584)3.63355418
31Chronic sinusitis (HP:0011109)3.59961874
32Infertility (HP:0000789)3.55726277
33Chronic bronchitis (HP:0004469)3.52991650
34Milia (HP:0001056)3.46208554
35Pili torti (HP:0003777)3.40379175
36Abdominal distention (HP:0003270)3.31001791
37Abnormality of chloride homeostasis (HP:0011422)3.25817567
38Abnormality of the pancreatic islet cells (HP:0006476)3.22656904
39Abnormality of endocrine pancreas physiology (HP:0012093)3.22656904
40Atrophic scars (HP:0001075)3.22361365
41Abnormality of renin-angiotensin system (HP:0000847)3.19549813
42Large for gestational age (HP:0001520)3.18636263
43Ketoacidosis (HP:0001993)3.18344590
44Abnormality of calcium-phosphate metabolism (HP:0100530)3.11746324
45Hypokalemia (HP:0002900)3.05677632
46Urinary glycosaminoglycan excretion (HP:0003541)2.90371758
47Mucopolysacchariduria (HP:0008155)2.90371758
48Progressive sensorineural hearing impairment (HP:0000408)2.86138307
49Curly hair (HP:0002212)2.85476262
50Pancreatic islet-cell hyperplasia (HP:0004510)2.84479504
51Atelectasis (HP:0100750)2.84139275
52Dysostosis multiplex (HP:0000943)2.81931827
53Hypoplasia of dental enamel (HP:0006297)2.80099228
54Insulin resistance (HP:0000855)2.76591102
55Hyperkalemia (HP:0002153)2.73260499
56Abnormality of purine metabolism (HP:0004352)2.70792692
57Interstitial pulmonary disease (HP:0006530)2.69994938
58Conjugated hyperbilirubinemia (HP:0002908)2.66576969
59Abnormality of polysaccharide metabolism (HP:0011012)2.62646196
60Abnormality of glycosaminoglycan metabolism (HP:0004371)2.62646196
61Abnormality of mucopolysaccharide metabolism (HP:0011020)2.62646196
62Chronic hepatic failure (HP:0100626)2.62618727
63Lip pit (HP:0100267)2.62180781
64Bell-shaped thorax (HP:0001591)2.60220478
65Occipital encephalocele (HP:0002085)2.59868835
66Renal salt wasting (HP:0000127)2.59671415
67Chronic otitis media (HP:0000389)2.59518473
68Abnormal biliary tract morphology (HP:0012440)2.58021356
69Progressive hearing impairment (HP:0001730)2.57501515
70Fragile nails (HP:0001808)2.57230872
71Genetic anticipation (HP:0003743)2.56328148
72Abnormality of potassium homeostasis (HP:0011042)2.55983104
73Cystic liver disease (HP:0006706)2.54539557
74Hypotension (HP:0002615)2.44592825
75Mildly elevated creatine phosphokinase (HP:0008180)2.44249407
76Osteomalacia (HP:0002749)2.40898755
77Micronodular cirrhosis (HP:0001413)2.39957884
78Widely patent fontanelles and sutures (HP:0004492)2.32994258
79Ileus (HP:0002595)2.32194719
80Hyperaldosteronism (HP:0000859)2.31849822
81Goiter (HP:0000853)2.31375756
82Vacuolated lymphocytes (HP:0001922)2.29284330
83Increased purine levels (HP:0004368)2.26549218
84Hyperuricemia (HP:0002149)2.26549218
85Hyperphosphatemia (HP:0002905)2.26227478
86Nephronophthisis (HP:0000090)2.25495750
87True hermaphroditism (HP:0010459)2.22998714
88Recurrent bronchitis (HP:0002837)2.22722203
89Generalized aminoaciduria (HP:0002909)2.21666043
90Hypoplastic labia majora (HP:0000059)2.18388781
91Pancreatic fibrosis (HP:0100732)2.17717994
92Thoracolumbar scoliosis (HP:0002944)2.15123224
93Plantar hyperkeratosis (HP:0007556)2.09466598
94Abnormal hair laboratory examination (HP:0003328)2.09110936
95Abnormality of the fovea (HP:0000493)2.06478254
96Unilateral renal agenesis (HP:0000122)2.05742590
97Protuberant abdomen (HP:0001538)2.03563881
98Abnormality of cochlea (HP:0000375)2.03459775
99Cone-rod dystrophy (HP:0000548)2.02999596
100Abnormality of the fingertips (HP:0001211)2.01542968
101Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.8421074
102Dynein arm defect of respiratory motile cilia (HP:0012255)10.0832168
103Absent/shortened dynein arms (HP:0200106)10.0832168
104Hyponatremia (HP:0002902)1.99910638
105Abnormality of the renal medulla (HP:0100957)1.98422509
106Biliary tract neoplasm (HP:0100574)1.95231312
107Abnormality of the intrinsic pathway (HP:0010989)1.94314186
108Abnormality of the labia majora (HP:0012881)1.93910391
109Aplasia/Hypoplasia of the fovea (HP:0008060)1.93406811
110Hypoplasia of the fovea (HP:0007750)1.93406811
111Abnormality of the gastric mucosa (HP:0004295)1.92846346
112Flat acetabular roof (HP:0003180)1.90030926
113Pustule (HP:0200039)1.88428260
114Thin bony cortex (HP:0002753)1.88011910
115Abnormality of midbrain morphology (HP:0002418)1.87152952
116Molar tooth sign on MRI (HP:0002419)1.87152952
117Arterial tortuosity (HP:0005116)1.84986085
118Tubular atrophy (HP:0000092)1.84408285
119Dehydration (HP:0001944)1.84207376
120Abnormality of the distal phalanges of the toes (HP:0010182)1.82957488
121Obstructive sleep apnea (HP:0002870)1.81688121
122Exocrine pancreatic insufficiency (HP:0001738)1.81533743
123Alopecia of scalp (HP:0002293)1.80995064
124Congenital glaucoma (HP:0001087)1.79095896
125Hoarse voice (HP:0001609)1.77576586
126Glomerulosclerosis (HP:0000096)1.75623406
127Severe short stature (HP:0003510)1.74896412
128Hypokalemic alkalosis (HP:0001949)1.73391567
129Rectal prolapse (HP:0002035)1.72908262
130Tubulointerstitial fibrosis (HP:0005576)1.72413498
131Adrenal overactivity (HP:0002717)1.71514623
132Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.70549435
133Syncope (HP:0001279)1.68578903
134Pancreatic cysts (HP:0001737)1.66514268
135Malnutrition (HP:0004395)1.65948815
136Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.65883711
137Tubulointerstitial nephritis (HP:0001970)1.64696784
138Abnormality of renal excretion (HP:0011036)1.64031327
139Abnormality of alkaline phosphatase activity (HP:0004379)1.63220935
140Aplasia/hypoplasia of the uterus (HP:0008684)1.62703962
141Spinal muscular atrophy (HP:0007269)1.61161133
142Postaxial foot polydactyly (HP:0001830)1.60447789
143Congenital hepatic fibrosis (HP:0002612)1.56853857
144Short nail (HP:0001799)1.56771904
145Abnormality of the dental pulp (HP:0006479)1.48857452
146Tubulointerstitial abnormality (HP:0001969)1.47385168
147Absent frontal sinuses (HP:0002688)1.45336482
148Abnormality of sodium homeostasis (HP:0010931)1.45299951
149Abnormality of the dental root (HP:0006486)1.43112628
150Taurodontia (HP:0000679)1.43112628
151Abnormality of permanent molar morphology (HP:0011071)1.43112628
152Abnormality of monocarboxylic acid metabolism (HP:0010996)1.42379230
153Anencephaly (HP:0002323)1.40343252
154Progressive cerebellar ataxia (HP:0002073)1.39518161
155Distal upper limb amyotrophy (HP:0007149)1.35648782
156Upper limb amyotrophy (HP:0009129)1.35648782
157Self-mutilation (HP:0000742)1.35162155
158Oligodontia (HP:0000677)1.34698819
159Abnormal vertebral ossification (HP:0100569)1.34574886
160Absent rod-and cone-mediated responses on ERG (HP:0007688)1.34487618
161Dysmetric saccades (HP:0000641)1.34438451
162Abnormality of molar (HP:0011077)1.32586218
163Abnormality of molar morphology (HP:0011070)1.32586218
164Down-sloping shoulders (HP:0200021)1.31770528
165Hemorrhage of the eye (HP:0011885)1.31768857
166Short thorax (HP:0010306)1.30493627
167Stage 5 chronic kidney disease (HP:0003774)1.27395285
168Hand muscle atrophy (HP:0009130)1.22755617
169Male pseudohermaphroditism (HP:0000037)1.20210722
170Popliteal pterygium (HP:0009756)1.18585600
171Abnormality of dentin (HP:0010299)1.17566577
172Alkalosis (HP:0001948)1.13815335
173Nephropathy (HP:0000112)1.11459055
174Aplasia/Hypoplasia of the tongue (HP:0010295)1.10626341
175Sclerocornea (HP:0000647)1.10339483
176Bifid scrotum (HP:0000048)1.10146497
177Aplasia/Hypoplasia of the spleen (HP:0010451)1.08270303
178Spinal cord compression (HP:0002176)1.07974418
179Decreased central vision (HP:0007663)1.07153843

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA27.28254641
2INSRR4.38437818
3FRK4.33922847
4MAPK153.82620940
5RIPK13.68971911
6MAP3K23.02079276
7PASK3.00081562
8MST1R2.89614037
9CDK122.45764706
10MAP2K22.34236480
11MST42.32837139
12TAOK32.32818785
13ERN12.24222838
14PIK3CA2.19821116
15PTK22.10725171
16SMG11.80903549
17PRKD31.80257174
18HIPK21.77147045
19MET1.74889534
20ICK1.72760594
21PTK61.72720101
22MAPKAPK31.68816611
23MAP3K71.57843166
24LMTK21.57763290
25FER1.52449976
26MAP3K31.51322048
27SIK21.50629932
28TESK11.49535403
29WNK41.49391235
30MAP3K11.40056248
31EPHA31.38612440
32EPHB11.33657894
33MARK21.33041281
34EEF2K1.29855020
35LATS11.29037101
36PRKG21.20041673
37CAMKK11.19076103
38CAMK1G1.17282073
39STK241.17024174
40EPHB21.15205097
41NLK1.09087966
42SIK11.07131753
43CAMK1D1.05778419
44BCR1.04204993
45ACVR1B1.02595872
46FLT30.94368808
47PRKCI0.93873539
48TRIB30.91922969
49WNK10.85562713
50PDGFRA0.84418219
51NEK20.83480682
52NME10.80760484
53NTRK10.80389482
54PAK30.78933638
55STK390.78834415
56MAP2K10.77771861
57PDGFRB0.74489316
58ERBB30.74483221
59CDC42BPA0.70530789
60DMPK0.70288447
61ZAP700.69913890
62CHUK0.68232203
63PTK2B0.67805962
64IRAK30.67567558
65TTK0.65825476
66FGFR40.65068164
67AKT30.64589353
68STK380.62822612
69TAOK10.61790897
70DYRK1B0.61110722
71MAP3K100.61011009
72KSR20.60181307
73MAP3K60.58874942
74PNCK0.57218055
75MAP2K60.56336309
76NEK60.56093247
77ERBB20.55261370
78MAP3K130.52982474
79CAMK2D0.52587255
80LRRK20.52178782
81GSK3A0.46992196
82PRKCH0.45811128
83PAK40.45614878
84TYK20.44840391
85PRKCE0.43861545
86BRD40.42850357
87CASK0.41180376
88TBK10.40495662
89ERBB40.39538873
90MAP3K90.39311708
91RPS6KB20.38205195
92MAP3K140.37555796
93PBK0.36836439
94PRKAA10.35304267
95RIPK40.34894723
96TRPM70.34749085
97MAPK110.34106294
98PRKD10.33601366
99BLK0.33085770
100JAK20.32328826
101PKN20.32322668
102CSNK1A10.31849886
103RET0.31633125
104RPS6KA20.31508860
105CSK0.31484865
106SRC0.31093343
107ITK0.30868992
108PRKD20.30851827
109FGFR30.30630153
110STK100.30499218
111BMX0.30194589
112PRKAA20.29804029
113NUAK10.28635321
114SCYL20.28540974
115PRKCD0.27756768
116JAK10.27300541
117SGK20.26987012
118STK38L0.26842991
119TGFBR20.26671165
120TNK20.25354097
121IRAK10.23689740
122DDR20.23440404
123MTOR0.23365583
124IGF1R0.23051328
125FYN0.23011037
126OXSR10.20871625
127EGFR0.19781961
128ADRBK10.19562672
129GRK10.19523935
130JAK30.19275497
131CDK90.19247838
132PRKCA0.19128257
133CDK80.18721961
134PDPK10.18691062
135SGK2230.17750251
136SGK4940.17750251
137MELK0.16740591
138SGK10.16601072
139PIK3CG0.16573983
140SGK30.16005954
141EIF2AK30.15861500
142PRKACG0.14246122
143PAK20.13972511
144MATK0.13501477

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049507.24121879
2Sulfur metabolism_Homo sapiens_hsa009203.65684119
3Protein export_Homo sapiens_hsa030603.32721650
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.53972291
5Mineral absorption_Homo sapiens_hsa049782.49459990
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.47864320
7Carbohydrate digestion and absorption_Homo sapiens_hsa049732.21333618
8Insulin secretion_Homo sapiens_hsa049112.07682303
9Retinol metabolism_Homo sapiens_hsa008302.05035656
10Fat digestion and absorption_Homo sapiens_hsa049752.03366324
11Vibrio cholerae infection_Homo sapiens_hsa051101.95259697
12Notch signaling pathway_Homo sapiens_hsa043301.90047950
13Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.85411529
14Type II diabetes mellitus_Homo sapiens_hsa049301.63910015
15beta-Alanine metabolism_Homo sapiens_hsa004101.62645921
16Thyroid hormone synthesis_Homo sapiens_hsa049181.58662452
17Cyanoamino acid metabolism_Homo sapiens_hsa004601.57628261
18Linoleic acid metabolism_Homo sapiens_hsa005911.56998130
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.56139775
20Histidine metabolism_Homo sapiens_hsa003401.51430686
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.46646901
22Galactose metabolism_Homo sapiens_hsa000521.41954251
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.39639704
24N-Glycan biosynthesis_Homo sapiens_hsa005101.36785444
25Pancreatic secretion_Homo sapiens_hsa049721.34488552
26Glycosaminoglycan degradation_Homo sapiens_hsa005311.33233621
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26249033
28Other glycan degradation_Homo sapiens_hsa005111.24743274
29Tight junction_Homo sapiens_hsa045301.21385373
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.17816239
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.16171537
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.14604767
33Bile secretion_Homo sapiens_hsa049761.13179487
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.09212920
35Selenocompound metabolism_Homo sapiens_hsa004501.08665967
36Choline metabolism in cancer_Homo sapiens_hsa052311.07283192
37Lysine degradation_Homo sapiens_hsa003101.02565373
38Nitrogen metabolism_Homo sapiens_hsa009101.02538739
39Pentose and glucuronate interconversions_Homo sapiens_hsa000400.99361061
40Renin-angiotensin system_Homo sapiens_hsa046140.98463180
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.98076568
42Huntingtons disease_Homo sapiens_hsa050160.96886819
43Folate biosynthesis_Homo sapiens_hsa007900.96235351
44Adherens junction_Homo sapiens_hsa045200.94601595
45Starch and sucrose metabolism_Homo sapiens_hsa005000.94081889
46Lysosome_Homo sapiens_hsa041420.93293817
47Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91900762
48Insulin resistance_Homo sapiens_hsa049310.91001417
49Cocaine addiction_Homo sapiens_hsa050300.90512911
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.89912141
51Sphingolipid metabolism_Homo sapiens_hsa006000.87722351
52Tryptophan metabolism_Homo sapiens_hsa003800.86404580
53Prolactin signaling pathway_Homo sapiens_hsa049170.85707903
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85445143
55Caffeine metabolism_Homo sapiens_hsa002320.80671461
56Phenylalanine metabolism_Homo sapiens_hsa003600.80613384
57ABC transporters_Homo sapiens_hsa020100.78257976
58Type I diabetes mellitus_Homo sapiens_hsa049400.73249889
59Circadian rhythm_Homo sapiens_hsa047100.69980577
60Protein digestion and absorption_Homo sapiens_hsa049740.67776725
61Bladder cancer_Homo sapiens_hsa052190.67508561
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67401780
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67168583
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67071347
65Thyroid cancer_Homo sapiens_hsa052160.66251827
66Antigen processing and presentation_Homo sapiens_hsa046120.66109207
67Glucagon signaling pathway_Homo sapiens_hsa049220.66077652
68ECM-receptor interaction_Homo sapiens_hsa045120.65897524
69Ether lipid metabolism_Homo sapiens_hsa005650.64487555
70Toxoplasmosis_Homo sapiens_hsa051450.64130717
71Nicotine addiction_Homo sapiens_hsa050330.64084029
72Legionellosis_Homo sapiens_hsa051340.64057647
73Estrogen signaling pathway_Homo sapiens_hsa049150.62255995
74Fructose and mannose metabolism_Homo sapiens_hsa000510.62252085
75Glycerolipid metabolism_Homo sapiens_hsa005610.60028545
76Salivary secretion_Homo sapiens_hsa049700.59381212
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.58404123
78Amoebiasis_Homo sapiens_hsa051460.57883973
79Arachidonic acid metabolism_Homo sapiens_hsa005900.56651685
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55089115
81Arginine biosynthesis_Homo sapiens_hsa002200.55031301
82Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54845610
83Taste transduction_Homo sapiens_hsa047420.53548590
84Serotonergic synapse_Homo sapiens_hsa047260.52756971
85Hepatitis C_Homo sapiens_hsa051600.51629056
86Dorso-ventral axis formation_Homo sapiens_hsa043200.51621382
87Tyrosine metabolism_Homo sapiens_hsa003500.51026091
88Inositol phosphate metabolism_Homo sapiens_hsa005620.49757163
89TNF signaling pathway_Homo sapiens_hsa046680.49514647
90PPAR signaling pathway_Homo sapiens_hsa033200.48689747
91Pertussis_Homo sapiens_hsa051330.46783625
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46631175
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44648363
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44605184
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.44202558
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.43748776
97Prostate cancer_Homo sapiens_hsa052150.42739042
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.42689285
99Vitamin digestion and absorption_Homo sapiens_hsa049770.42066379
100Amphetamine addiction_Homo sapiens_hsa050310.42038569
101Renal cell carcinoma_Homo sapiens_hsa052110.41525246
102Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41119382
103Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40443144
104Gastric acid secretion_Homo sapiens_hsa049710.40429959
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39531481
106Arginine and proline metabolism_Homo sapiens_hsa003300.39153328
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.38647173
108Influenza A_Homo sapiens_hsa051640.38529620
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35955286
110Focal adhesion_Homo sapiens_hsa045100.35813640
111Ovarian steroidogenesis_Homo sapiens_hsa049130.35503534
112Calcium signaling pathway_Homo sapiens_hsa040200.34505363
113Fatty acid biosynthesis_Homo sapiens_hsa000610.34357857
114Salmonella infection_Homo sapiens_hsa051320.33056269
115Small cell lung cancer_Homo sapiens_hsa052220.32542037
116Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.32303236
117cAMP signaling pathway_Homo sapiens_hsa040240.32210332
118Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31615579
119GnRH signaling pathway_Homo sapiens_hsa049120.31512272
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30117486
121Glutathione metabolism_Homo sapiens_hsa004800.29817402
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29296175
123Insulin signaling pathway_Homo sapiens_hsa049100.28760771
124Peroxisome_Homo sapiens_hsa041460.28619777
125Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.28541424
126Graft-versus-host disease_Homo sapiens_hsa053320.28529929
127Renin secretion_Homo sapiens_hsa049240.27955976
128Autoimmune thyroid disease_Homo sapiens_hsa053200.27283615
129Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.27004228
130Fatty acid degradation_Homo sapiens_hsa000710.26738863
131Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.26220413
132Proteoglycans in cancer_Homo sapiens_hsa052050.25679290
133Endometrial cancer_Homo sapiens_hsa052130.25591267
134Leishmaniasis_Homo sapiens_hsa051400.25368112
135Hippo signaling pathway_Homo sapiens_hsa043900.24889224
136Chemical carcinogenesis_Homo sapiens_hsa052040.24741009
137Melanogenesis_Homo sapiens_hsa049160.23936311
138AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.23864337
139Axon guidance_Homo sapiens_hsa043600.23860731
140Allograft rejection_Homo sapiens_hsa053300.23756434
141Complement and coagulation cascades_Homo sapiens_hsa046100.23486277
142cGMP-PKG signaling pathway_Homo sapiens_hsa040220.22663519
143Glutamatergic synapse_Homo sapiens_hsa047240.22570992
144Chronic myeloid leukemia_Homo sapiens_hsa052200.21627984

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