MTURN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.78920510
2central nervous system myelination (GO:0022010)5.75422653
3axon ensheathment in central nervous system (GO:0032291)5.75422653
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.73942644
5locomotory exploration behavior (GO:0035641)5.56392650
6layer formation in cerebral cortex (GO:0021819)5.45080374
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.42777289
8vocalization behavior (GO:0071625)5.37911047
9L-amino acid import (GO:0043092)5.13476031
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.03026886
11pyrimidine nucleobase catabolic process (GO:0006208)4.96431975
12synaptic vesicle exocytosis (GO:0016079)4.95643926
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.94219129
14glutamate secretion (GO:0014047)4.85272682
15neuron cell-cell adhesion (GO:0007158)4.82477551
16exploration behavior (GO:0035640)4.79675385
17protein localization to synapse (GO:0035418)4.79099420
18regulation of synaptic vesicle exocytosis (GO:2000300)4.76605844
19regulation of glutamate receptor signaling pathway (GO:1900449)4.60367932
20proline transport (GO:0015824)4.52615343
21neuronal ion channel clustering (GO:0045161)4.47748836
22amino acid import (GO:0043090)4.45665389
23synaptic vesicle docking involved in exocytosis (GO:0016081)4.41283037
24dendritic spine morphogenesis (GO:0060997)4.39313767
25regulation of synapse structural plasticity (GO:0051823)4.35634232
26potassium ion homeostasis (GO:0055075)4.31393640
27potassium ion import (GO:0010107)4.21585712
28dendrite morphogenesis (GO:0048813)4.19171173
29nucleobase catabolic process (GO:0046113)4.19041617
30regulation of synaptic vesicle transport (GO:1902803)4.18347776
31neurotransmitter secretion (GO:0007269)4.09227900
32neuron recognition (GO:0008038)4.09205245
33cell migration in hindbrain (GO:0021535)4.03215520
34ionotropic glutamate receptor signaling pathway (GO:0035235)3.98280871
35regulation of neuronal synaptic plasticity (GO:0048168)3.95887524
36regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.95027713
37regulation of long-term neuronal synaptic plasticity (GO:0048169)3.93948253
38positive regulation of synapse maturation (GO:0090129)3.93079137
39axonal fasciculation (GO:0007413)3.86963795
40gamma-aminobutyric acid transport (GO:0015812)3.86048370
41cellular sodium ion homeostasis (GO:0006883)3.77686468
42regulation of voltage-gated calcium channel activity (GO:1901385)3.76088992
43activation of protein kinase A activity (GO:0034199)3.76088157
44negative regulation of synaptic transmission, GABAergic (GO:0032229)3.74163116
45regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.69727683
46neurotransmitter-gated ion channel clustering (GO:0072578)3.69008513
47gamma-aminobutyric acid signaling pathway (GO:0007214)3.68267862
48central nervous system projection neuron axonogenesis (GO:0021952)3.64266922
49neurotransmitter uptake (GO:0001504)3.58442855
50glutamate receptor signaling pathway (GO:0007215)3.54478406
51synaptic transmission, glutamatergic (GO:0035249)3.52857148
52regulation of neurotransmitter transport (GO:0051588)3.51972416
53negative regulation of microtubule polymerization (GO:0031115)3.50222948
54postsynaptic membrane organization (GO:0001941)3.48537585
55presynaptic membrane organization (GO:0097090)3.45747332
56mitochondrion transport along microtubule (GO:0047497)3.42250968
57establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.42250968
58long-term memory (GO:0007616)3.39094813
59positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.38840835
60regulation of dendritic spine morphogenesis (GO:0061001)3.37940340
61positive regulation of membrane potential (GO:0045838)3.37885497
62negative regulation of dendrite morphogenesis (GO:0050774)3.36739345
63clathrin coat assembly (GO:0048268)3.36197833
64sodium ion export (GO:0071436)3.34197739
65cellular potassium ion homeostasis (GO:0030007)3.32906476
66organelle transport along microtubule (GO:0072384)3.32846292
67neuronal action potential propagation (GO:0019227)3.29231473
68presynaptic membrane assembly (GO:0097105)3.27933179
69neuron-neuron synaptic transmission (GO:0007270)3.27712557
70neurotransmitter transport (GO:0006836)3.27363318
71positive regulation of neurotransmitter transport (GO:0051590)3.26829934
72positive regulation of neurotransmitter secretion (GO:0001956)3.26586988
73cell communication by electrical coupling (GO:0010644)3.26539550
74acidic amino acid transport (GO:0015800)3.25661956
75establishment of mitochondrion localization (GO:0051654)3.24371748
76regulation of excitatory postsynaptic membrane potential (GO:0060079)3.23640799
77neuromuscular process controlling balance (GO:0050885)3.23548075
78positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.23071735
79axon extension (GO:0048675)3.22616018
80cytoskeletal anchoring at plasma membrane (GO:0007016)3.19806162
81membrane depolarization (GO:0051899)3.18738667
82synaptic vesicle endocytosis (GO:0048488)3.17973770
83long-term synaptic potentiation (GO:0060291)3.17241929
84vesicle transport along microtubule (GO:0047496)3.16004504
85axon cargo transport (GO:0008088)3.15292967
86cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.15099628
87membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.14737587
88positive regulation of synaptic transmission, GABAergic (GO:0032230)3.13861673
89cell differentiation in hindbrain (GO:0021533)3.13394746
90regulation of postsynaptic membrane potential (GO:0060078)3.11053351
91innervation (GO:0060384)3.09767414
92synapse assembly (GO:0007416)3.09573385
93regulation of neurotransmitter secretion (GO:0046928)3.08889507
94regulation of synaptic transmission (GO:0050804)3.07667871
95regulation of cAMP-dependent protein kinase activity (GO:2000479)3.07035771
96auditory behavior (GO:0031223)3.03972439
97regulation of synaptic plasticity (GO:0048167)3.03956726
98transmission of nerve impulse (GO:0019226)3.02800137
99regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.02221932
100regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.02037075
101cell communication involved in cardiac conduction (GO:0086065)3.01916210
102positive regulation of dendritic spine development (GO:0060999)2.99724529
103regulation of vesicle fusion (GO:0031338)2.98760955
104neuromuscular process controlling posture (GO:0050884)2.98577837
105regulation of neurotransmitter levels (GO:0001505)2.97994207
106detection of calcium ion (GO:0005513)2.96767760
107positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.96765621
108positive regulation of dendritic spine morphogenesis (GO:0061003)2.95943095
109regulation of synapse maturation (GO:0090128)2.95319478
110positive regulation of axon extension (GO:0045773)2.95207927
111cerebellar Purkinje cell differentiation (GO:0021702)2.94289128
112G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.93784150
113regulation of dendritic spine development (GO:0060998)2.92846185
114dendritic spine organization (GO:0097061)2.92844662
115long-chain fatty acid biosynthetic process (GO:0042759)2.92445712
116neuromuscular process (GO:0050905)2.92135875
117response to auditory stimulus (GO:0010996)2.92102555
118cerebellar Purkinje cell layer development (GO:0021680)2.91823326
119regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.91632531
120establishment of nucleus localization (GO:0040023)2.91453070
121intraspecies interaction between organisms (GO:0051703)2.91429759
122social behavior (GO:0035176)2.91429759
123neuron projection extension (GO:1990138)2.91310911
124vesicle docking involved in exocytosis (GO:0006904)2.90982864
125regulation of ARF protein signal transduction (GO:0032012)2.90944252
126positive regulation of dendrite development (GO:1900006)2.89891752
127L-glutamate transport (GO:0015813)2.89856892
128glycine transport (GO:0015816)2.89433983
129synaptic transmission (GO:0007268)2.89102306
130central nervous system neuron axonogenesis (GO:0021955)2.87688158
131adult walking behavior (GO:0007628)2.86727022
132synapse organization (GO:0050808)2.85912879
133dopamine receptor signaling pathway (GO:0007212)2.85682631
134regulation of synaptic transmission, glutamatergic (GO:0051966)2.84140574
135cerebellum development (GO:0021549)2.83900610
136cerebellar granule cell differentiation (GO:0021707)2.80558544
137membrane depolarization during action potential (GO:0086010)2.80051626

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.96215473
2GBX2_23144817_ChIP-Seq_PC3_Human3.07360403
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.97808272
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.89911033
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.84108125
6REST_21632747_ChIP-Seq_MESCs_Mouse2.62699248
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.61917159
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.61917159
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.50090803
10SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.44983832
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.44465105
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.44122387
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.43347929
14DROSHA_22980978_ChIP-Seq_HELA_Human2.43047190
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.40795197
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37307520
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.29206781
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.27056714
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.22006458
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.18602689
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.17015742
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.12499228
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.08103137
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.06628877
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.04862659
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.04441218
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.99193389
28AR_21572438_ChIP-Seq_LNCaP_Human1.94109017
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88156089
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.84636167
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.72265954
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66984233
33ZNF274_21170338_ChIP-Seq_K562_Hela1.59943009
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48587645
35SMAD4_21799915_ChIP-Seq_A2780_Human1.48560472
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.46439231
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46272054
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44531819
39RING1B_27294783_Chip-Seq_ESCs_Mouse1.39681385
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.39672139
41NR3C1_23031785_ChIP-Seq_PC12_Mouse1.35513071
42SOX2_21211035_ChIP-Seq_LN229_Gbm1.34056475
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32724318
44TAF15_26573619_Chip-Seq_HEK293_Human1.31712608
45WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.30993892
46KDM2B_26808549_Chip-Seq_K562_Human1.28830119
47SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28709602
48ZFP281_18757296_ChIP-ChIP_E14_Mouse1.28041925
49SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.27646976
50TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.25546528
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.25407160
52RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.25264652
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25144132
54DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24436371
55RING1B_27294783_Chip-Seq_NPCs_Mouse1.22532272
56CTNNB1_20460455_ChIP-Seq_HCT116_Human1.22352512
57AR_19668381_ChIP-Seq_PC3_Human1.21601897
58WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21547888
59ESR2_21235772_ChIP-Seq_MCF-7_Human1.20225488
60AR_25329375_ChIP-Seq_VCAP_Human1.19900134
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18674994
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17875889
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16309967
64P300_19829295_ChIP-Seq_ESCs_Human1.15817875
65ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14838610
66EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14777720
67AHR_22903824_ChIP-Seq_MCF-7_Human1.14585345
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.14280139
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.14219896
70CBX2_27304074_Chip-Seq_ESCs_Mouse1.13090445
71IGF1R_20145208_ChIP-Seq_DFB_Human1.12940923
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12631823
73TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11940824
74SMAD_19615063_ChIP-ChIP_OVARY_Human1.09973969
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.09669740
76STAT3_23295773_ChIP-Seq_U87_Human1.09433610
77YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09430234
78ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09029561
79TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05738557
80TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04725542
81SMAD4_21741376_ChIP-Seq_HESCs_Human1.02424583
82ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.01280341
83P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01214877
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00910463
85EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.96834608
86RNF2_27304074_Chip-Seq_NSC_Mouse0.96798219
87SMAD3_21741376_ChIP-Seq_ESCs_Human0.96424846
88BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96324343
89TCF4_23295773_ChIP-Seq_U87_Human0.95433699
90GATA1_26923725_Chip-Seq_HPCs_Mouse0.94629333
91PRDM14_20953172_ChIP-Seq_ESCs_Human0.92085882
92NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91047566
93MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90947114
94ZFP281_27345836_Chip-Seq_ESCs_Mouse0.89813666
95GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89759124
96CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89666612
97RBPJ_22232070_ChIP-Seq_NCS_Mouse0.89201160
98ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89069303
99OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.88486572
100RUNX2_22187159_ChIP-Seq_PCA_Human0.87880775
101BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87876360
102TET1_21490601_ChIP-Seq_MESCs_Mouse0.87576114
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87119211
104TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87119211
105DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.86874451
106SMAD3_21741376_ChIP-Seq_HESCs_Human0.85751397
107TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84796483
108VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.84423050
109DPY_21335234_ChIP-Seq_ESCs_Mouse0.84089570
110SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83817598
111PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.83641131
112OCT4_19829295_ChIP-Seq_ESCs_Human0.83562211
113CTCF_27219007_Chip-Seq_Bcells_Human0.83329562
114KDM2B_26808549_Chip-Seq_SUP-B15_Human0.82825895
115TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.82083744
116RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.81772017
117LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80324224
118EP300_21415370_ChIP-Seq_HL-1_Mouse0.77112695
119LXR_22292898_ChIP-Seq_THP-1_Human0.75244075

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.36452908
2MP0004270_analgesia4.22371452
3MP0003880_abnormal_central_pattern4.09063005
4MP0003635_abnormal_synaptic_transmissio3.99503917
5MP0002063_abnormal_learning/memory/cond3.26758037
6MP0005423_abnormal_somatic_nervous3.14401863
7MP0001968_abnormal_touch/_nociception2.99159149
8MP0009745_abnormal_behavioral_response2.98615125
9MP0002734_abnormal_mechanical_nocicepti2.97794407
10MP0002735_abnormal_chemical_nociception2.77484883
11MP0002064_seizures2.73074164
12MP0009046_muscle_twitch2.54851837
13MP0002572_abnormal_emotion/affect_behav2.51980087
14MP0000778_abnormal_nervous_system2.51259554
15MP0009780_abnormal_chondrocyte_physiolo2.41965009
16MP0004858_abnormal_nervous_system2.35764425
17MP0002733_abnormal_thermal_nociception2.33757065
18MP0002736_abnormal_nociception_after2.24745860
19MP0001486_abnormal_startle_reflex2.22576212
20MP0002184_abnormal_innervation2.15441935
21MP0001440_abnormal_grooming_behavior2.14781238
22MP0002272_abnormal_nervous_system2.11818244
23MP0003329_amyloid_beta_deposits2.11789762
24MP0001970_abnormal_pain_threshold2.06889619
25MP0004811_abnormal_neuron_physiology2.02096673
26MP0006276_abnormal_autonomic_nervous2.00965597
27MP0002909_abnormal_adrenal_gland1.93083861
28MP0002067_abnormal_sensory_capabilities1.87736580
29MP0001501_abnormal_sleep_pattern1.81383928
30MP0002557_abnormal_social/conspecific_i1.78187220
31MP0004885_abnormal_endolymph1.76989599
32MP0000955_abnormal_spinal_cord1.76157767
33MP0004924_abnormal_behavior1.73984352
34MP0005386_behavior/neurological_phenoty1.73984352
35MP0008569_lethality_at_weaning1.72676128
36MP0002822_catalepsy1.66644627
37MP0000569_abnormal_digit_pigmentation1.63925154
38MP0002882_abnormal_neuron_morphology1.53352685
39MP0001984_abnormal_olfaction1.47754227
40MP0002066_abnormal_motor_capabilities/c1.42206957
41MP0003879_abnormal_hair_cell1.34236960
42MP0003787_abnormal_imprinting1.33493981
43MP0005645_abnormal_hypothalamus_physiol1.33128107
44MP0003633_abnormal_nervous_system1.26782955
45MP0002152_abnormal_brain_morphology1.25623966
46MP0000751_myopathy1.21315105
47MP0005167_abnormal_blood-brain_barrier1.20055682
48MP0003123_paternal_imprinting1.12226918
49MP0004130_abnormal_muscle_cell1.07105442
50MP0003631_nervous_system_phenotype1.07048162
51MP0005499_abnormal_olfactory_system1.06047192
52MP0005394_taste/olfaction_phenotype1.06047192
53MP0001502_abnormal_circadian_rhythm1.04648016
54MP0004147_increased_porphyrin_level1.02977781
55MP0005187_abnormal_penis_morphology1.02432575
56MP0003075_altered_response_to1.01635575
57MP0002069_abnormal_eating/drinking_beha0.97443117
58MP0003634_abnormal_glial_cell0.97202293
59MP0005646_abnormal_pituitary_gland0.96992687
60MP0008961_abnormal_basal_metabolism0.96827546
61MP0000604_amyloidosis0.96251638
62MP0002837_dystrophic_cardiac_calcinosis0.95885191
63MP0003283_abnormal_digestive_organ0.93667158
64MP0001348_abnormal_lacrimal_gland0.93582130
65MP0010386_abnormal_urinary_bladder0.92273580
66MP0001905_abnormal_dopamine_level0.92168308
67MP0000013_abnormal_adipose_tissue0.91173712
68MP0005535_abnormal_body_temperature0.90415764
69MP0002229_neurodegeneration0.89536045
70MP0001485_abnormal_pinna_reflex0.87661502
71MP0004742_abnormal_vestibular_system0.86578611
72MP0004085_abnormal_heartbeat0.84781537
73MP0002752_abnormal_somatic_nervous0.82881413
74MP0000631_abnormal_neuroendocrine_gland0.80758758
75MP0003122_maternal_imprinting0.80755420
76MP0003861_abnormal_nervous_system0.80563008
77MP0001177_atelectasis0.80363491
78MP0004142_abnormal_muscle_tone0.79238127
79MP0001299_abnormal_eye_distance/0.78774121
80MP0003137_abnormal_impulse_conducting0.76005600
81MP0004233_abnormal_muscle_weight0.75280585
82MP0003632_abnormal_nervous_system0.75003431
83MP0004145_abnormal_muscle_electrophysio0.74952819
84MP0001346_abnormal_lacrimal_gland0.73606749
85MP0004043_abnormal_pH_regulation0.71190042
86MP0008874_decreased_physiological_sensi0.70951939
87MP0004484_altered_response_of0.70854688
88MP0005409_darkened_coat_color0.70653529
89MP0001963_abnormal_hearing_physiology0.70401418
90MP0004215_abnormal_myocardial_fiber0.69729389
91MP0005551_abnormal_eye_electrophysiolog0.69545684
92MP0003045_fibrosis0.67959743
93MP0008872_abnormal_physiological_respon0.67553123
94MP0001986_abnormal_taste_sensitivity0.64436414
95MP0001188_hyperpigmentation0.63793407
96MP0008789_abnormal_olfactory_epithelium0.62877332
97MP0000920_abnormal_myelination0.62552578
98MP0003690_abnormal_glial_cell0.62273417
99MP0004510_myositis0.61808780
100MP0002090_abnormal_vision0.61262777
101MP0002638_abnormal_pupillary_reflex0.61150041
102MP0002876_abnormal_thyroid_physiology0.60880858
103MP0005623_abnormal_meninges_morphology0.60513805
104MP0001529_abnormal_vocalization0.59667793
105MP0010234_abnormal_vibrissa_follicle0.59351305
106MP0010769_abnormal_survival0.55871950
107MP0000579_abnormal_nail_morphology0.55163799
108MP0000537_abnormal_urethra_morphology0.54199754
109MP0010770_preweaning_lethality0.54147110
110MP0002082_postnatal_lethality0.54147110
111MP0000747_muscle_weakness0.54047611
112MP0002234_abnormal_pharynx_morphology0.52784925
113MP0010768_mortality/aging0.52508734
114MP0003172_abnormal_lysosome_physiology0.52175945
115MP0001943_abnormal_respiration0.51354067
116MP0005166_decreased_susceptibility_to0.48632245
117MP0003956_abnormal_body_size0.47632106
118MP0005388_respiratory_system_phenotype0.47403966
119MP0002133_abnormal_respiratory_system0.47403966

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.89099752
2Focal motor seizures (HP:0011153)5.23054260
3Visual hallucinations (HP:0002367)4.85113896
4Focal seizures (HP:0007359)4.67891423
5Supranuclear gaze palsy (HP:0000605)4.27453735
6Mutism (HP:0002300)4.07543219
7Epileptic encephalopathy (HP:0200134)3.84531936
8Ankle clonus (HP:0011448)3.80291091
9Progressive cerebellar ataxia (HP:0002073)3.66531142
10Action tremor (HP:0002345)3.65980833
11Amyotrophic lateral sclerosis (HP:0007354)3.51759135
12Papilledema (HP:0001085)3.43398741
13Atonic seizures (HP:0010819)3.29722720
14Febrile seizures (HP:0002373)3.26615670
15Broad-based gait (HP:0002136)3.23215122
16Termporal pattern (HP:0011008)3.21823941
17Insidious onset (HP:0003587)3.21823941
18Abnormality of the corticospinal tract (HP:0002492)3.21820952
19Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.18947168
20Degeneration of the lateral corticospinal tracts (HP:0002314)3.18947168
21Absence seizures (HP:0002121)3.18015242
22Urinary bladder sphincter dysfunction (HP:0002839)3.11145158
23Annular pancreas (HP:0001734)3.10883907
24Generalized tonic-clonic seizures (HP:0002069)3.08886931
25Poor eye contact (HP:0000817)3.07870466
26Drooling (HP:0002307)3.07835482
27Excessive salivation (HP:0003781)3.07835482
28Limb dystonia (HP:0002451)3.06745926
29Cerebral inclusion bodies (HP:0100314)3.06364071
30Tetraplegia (HP:0002445)3.06215346
31Urinary urgency (HP:0000012)3.05635058
32Abnormality of the lower motor neuron (HP:0002366)3.04558329
33Cerebral hypomyelination (HP:0006808)3.03790106
34Abnormal eating behavior (HP:0100738)3.01905331
35Neurofibrillary tangles (HP:0002185)3.01680579
36Impaired vibration sensation in the lower limbs (HP:0002166)2.95559252
37Abnormal social behavior (HP:0012433)2.88866773
38Impaired social interactions (HP:0000735)2.88866773
39Depression (HP:0000716)2.88029095
40Dialeptic seizures (HP:0011146)2.81661718
41Hyperventilation (HP:0002883)2.80858766
42Peripheral hypomyelination (HP:0007182)2.78957060
43Polyphagia (HP:0002591)2.76149893
44Amblyopia (HP:0000646)2.73893262
45Progressive inability to walk (HP:0002505)2.73314574
46Akinesia (HP:0002304)2.71604101
47Truncal ataxia (HP:0002078)2.68580778
48Status epilepticus (HP:0002133)2.63512520
49Genetic anticipation (HP:0003743)2.61328097
50Sleep apnea (HP:0010535)2.61045507
51Spastic gait (HP:0002064)2.60556656
52Megalencephaly (HP:0001355)2.59740973
53Torticollis (HP:0000473)2.58768404
54Abnormality of binocular vision (HP:0011514)2.57153105
55Diplopia (HP:0000651)2.57153105
56Inappropriate behavior (HP:0000719)2.57119227
57Anxiety (HP:0000739)2.55788387
58Delusions (HP:0000746)2.54607921
59Insomnia (HP:0100785)2.54165203
60Postural instability (HP:0002172)2.50903133
61Hemiparesis (HP:0001269)2.49891541
62Pheochromocytoma (HP:0002666)2.47229543
63Bundle branch block (HP:0011710)2.45451253
64Agitation (HP:0000713)2.45363872
65Obstructive sleep apnea (HP:0002870)2.43617413
66Lower limb muscle weakness (HP:0007340)2.40456793
67Fetal akinesia sequence (HP:0001989)2.40046137
68Rigidity (HP:0002063)2.38475705
69Apathy (HP:0000741)2.38222310
70Dysdiadochokinesis (HP:0002075)2.35229057
71Focal dystonia (HP:0004373)2.32897948
72Dysmetria (HP:0001310)2.32343303
73EEG with generalized epileptiform discharges (HP:0011198)2.31172354
74Epileptiform EEG discharges (HP:0011182)2.29730528
75Spastic tetraparesis (HP:0001285)2.28675451
76Hypsarrhythmia (HP:0002521)2.27768897
77Aplasia/Hypoplasia of the brainstem (HP:0007362)2.26600815
78Hypoplasia of the brainstem (HP:0002365)2.26600815
79Gaze-evoked nystagmus (HP:0000640)2.26249819
80Intention tremor (HP:0002080)2.22464079
81Stereotypic behavior (HP:0000733)2.19285454
82Bradykinesia (HP:0002067)2.17964256
83Choreoathetosis (HP:0001266)2.16778250
84Craniofacial dystonia (HP:0012179)2.14130191
85Pachygyria (HP:0001302)2.13745181
86Morphological abnormality of the pyramidal tract (HP:0002062)2.12139215
87Diminished motivation (HP:0000745)2.12078644
88Hepatoblastoma (HP:0002884)2.10629410
89Inability to walk (HP:0002540)2.09636787
90Aqueductal stenosis (HP:0002410)2.06919159
91Impaired smooth pursuit (HP:0007772)2.06166460
92Neuroendocrine neoplasm (HP:0100634)2.05945697
93Aplasia of the phalanges of the hand (HP:0009802)1.98561941
94Aplasia involving bones of the extremities (HP:0009825)1.98561941
95Aplasia involving bones of the upper limbs (HP:0009823)1.98561941
96Abnormality of salivation (HP:0100755)1.98155385
97Absent speech (HP:0001344)1.97187479
98Lissencephaly (HP:0001339)1.96897930
99Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.94506500
100CNS hypomyelination (HP:0003429)1.93379572
101Abnormality of saccadic eye movements (HP:0000570)1.92344568
102Heart block (HP:0012722)1.92016244
103Split foot (HP:0001839)1.90717929
104Ventricular fibrillation (HP:0001663)1.90167604
105Elfin facies (HP:0004428)1.90042530
106Clonus (HP:0002169)1.90007441
107Hemiplegia (HP:0002301)1.88390580
108Pointed chin (HP:0000307)1.87615143
109Hyperacusis (HP:0010780)1.87420201
110Dysmetric saccades (HP:0000641)1.87349469
111Abnormality of the periventricular white matter (HP:0002518)1.86839178
112Abnormality of ocular smooth pursuit (HP:0000617)1.84841507
113Lower limb asymmetry (HP:0100559)1.83692267
114Rapidly progressive (HP:0003678)1.82805025
115Impaired vibratory sensation (HP:0002495)1.81841656
116Lower limb amyotrophy (HP:0007210)1.81321873
117Increased circulating renin level (HP:0000848)1.80401966
118Decreased motor nerve conduction velocity (HP:0003431)1.79808305
119Neuronal loss in central nervous system (HP:0002529)1.78728440
120Scanning speech (HP:0002168)1.78108610
121Neoplasm of the peripheral nervous system (HP:0100007)1.78083195
122Macroorchidism (HP:0000053)1.74292711
123Sporadic (HP:0003745)1.74288364
124Sacral dimple (HP:0000960)1.70844576

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK16.38245515
2MAP3K93.75065881
3NTRK33.35316868
4MAP3K42.90804945
5MINK12.89791710
6EPHA42.53857355
7MAP2K72.34731435
8NTRK22.33581323
9PHKG12.15682176
10PHKG22.15682176
11PAK62.12267141
12DAPK22.12106115
13MAPK131.92463869
14NTRK11.83033820
15KSR21.77992833
16SIK21.77474595
17LATS21.77033652
18MAP2K41.73948296
19PRKD31.67159313
20CAMKK11.65830338
21KSR11.56894826
22CDK51.50004102
23DYRK21.39571701
24MAP3K121.36229718
25ARAF1.35924427
26ERBB31.29763655
27GRK51.24526862
28CASK1.21376245
29PLK21.18410462
30MAP3K21.18340850
31UHMK11.14975982
32RET1.11562369
33CSNK1G21.08942964
34WNK31.08886498
35PNCK1.08627772
36DAPK11.08355581
37STK381.07461118
38LMTK21.07148138
39TYRO31.03711251
40PRKCG1.03409421
41LIMK10.96972443
42CAMK2G0.94834851
43PAK30.94084789
44MARK20.93613560
45TAOK10.92127187
46TNIK0.91746629
47NEK60.88958842
48MAP3K130.88529353
49STK110.87485791
50BMPR20.87087625
51SGK2230.84417125
52SGK4940.84417125
53CDK140.83092365
54DYRK1A0.82043143
55CDK180.81862488
56CDK150.81399045
57PRPF4B0.79835114
58SCYL20.79571472
59RIPK40.78777234
60PRKCH0.78690923
61PRKCZ0.74365447
62OXSR10.72966208
63CAMKK20.72156844
64MAP3K60.71302623
65CAMK2A0.71008080
66CAMK1G0.69768750
67RIPK10.69704464
68CDK11A0.69704253
69CAMK40.68942839
70RPS6KA20.65710599
71ALK0.64546441
72ROCK20.64378184
73SGK30.63519870
74TNK20.62675369
75PKN10.62587213
76CAMK2D0.61792393
77SGK20.61541337
78MAPK120.59719018
79MAP3K110.59184354
80FES0.57948522
81SGK10.57619983
82CAMK10.56532511
83FGFR20.56234016
84CDK190.56171000
85CSNK1G30.53751306
86EPHB20.52837024
87WNK40.52188059
88FYN0.51297577
89CAMK2B0.48784901
90MAPKAPK50.48610787
91MAP3K10.47483181
92PDK30.47030484
93PDK40.47030484
94PDK10.46973920
95CSNK1A1L0.46916761
96PRKCE0.46327098
97PINK10.46110299
98BRSK10.45635247
99NEK10.45150558
100TRIB30.43379952
101PDPK10.42558817
102CDC42BPA0.42179633
103DAPK30.41757266
104BRAF0.41587583
105RPS6KA30.41368044
106MAP2K10.40613549
107FER0.38936750
108PRKG10.37668802
109ICK0.37205859
110ERBB20.37204475
111PTK2B0.36882914
112MAP2K60.36569251
113PRKD10.36160975
114RAF10.35373729
115JAK20.34999546
116PDGFRA0.34908548
117MAPK100.33522596
118ROCK10.32990724
119WNK10.32848077
120PRKCA0.32790892
121MAPK40.31532614
122STK390.30934279
123CCNB10.30770033
124PRKCB0.28656708
125BMX0.27960179

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.01022634
2Nicotine addiction_Homo sapiens_hsa050333.00442736
3Olfactory transduction_Homo sapiens_hsa047402.46591746
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.43803939
5Circadian entrainment_Homo sapiens_hsa047132.43095319
6GABAergic synapse_Homo sapiens_hsa047272.40011827
7Long-term potentiation_Homo sapiens_hsa047202.34598982
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.32100963
9Glutamatergic synapse_Homo sapiens_hsa047242.26383902
10Morphine addiction_Homo sapiens_hsa050322.15021496
11Dopaminergic synapse_Homo sapiens_hsa047282.09843659
12Amphetamine addiction_Homo sapiens_hsa050311.95799618
13Cholinergic synapse_Homo sapiens_hsa047251.89389443
14Salivary secretion_Homo sapiens_hsa049701.87950836
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.87278484
16Gastric acid secretion_Homo sapiens_hsa049711.80582444
17Insulin secretion_Homo sapiens_hsa049111.76776441
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66272634
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.66058573
20Renin secretion_Homo sapiens_hsa049241.60696461
21Axon guidance_Homo sapiens_hsa043601.58815521
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.56001747
23Long-term depression_Homo sapiens_hsa047301.49770923
24Oxytocin signaling pathway_Homo sapiens_hsa049211.49590276
25Taste transduction_Homo sapiens_hsa047421.47207494
26Serotonergic synapse_Homo sapiens_hsa047261.43358471
27Gap junction_Homo sapiens_hsa045401.42987768
28GnRH signaling pathway_Homo sapiens_hsa049121.39381308
29Cocaine addiction_Homo sapiens_hsa050301.36655032
30Type II diabetes mellitus_Homo sapiens_hsa049301.33704180
31Glioma_Homo sapiens_hsa052141.29484795
32Estrogen signaling pathway_Homo sapiens_hsa049151.27370090
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26196248
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25540531
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.23314997
36Calcium signaling pathway_Homo sapiens_hsa040201.23099011
37ErbB signaling pathway_Homo sapiens_hsa040121.18761930
38cAMP signaling pathway_Homo sapiens_hsa040241.12477667
39Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.09499004
40Collecting duct acid secretion_Homo sapiens_hsa049661.09475949
41Vitamin B6 metabolism_Homo sapiens_hsa007501.04052599
42Melanogenesis_Homo sapiens_hsa049161.03637539
43Endometrial cancer_Homo sapiens_hsa052131.01749261
44Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99478333
45cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97449120
46Neurotrophin signaling pathway_Homo sapiens_hsa047220.90137453
47Dorso-ventral axis formation_Homo sapiens_hsa043200.89493932
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87189825
49Phospholipase D signaling pathway_Homo sapiens_hsa040720.87003554
50Oocyte meiosis_Homo sapiens_hsa041140.84737272
51Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82895274
52Choline metabolism in cancer_Homo sapiens_hsa052310.82444013
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82171015
54VEGF signaling pathway_Homo sapiens_hsa043700.81006279
55Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80471295
56mTOR signaling pathway_Homo sapiens_hsa041500.79842948
57Cardiac muscle contraction_Homo sapiens_hsa042600.78558036
58Histidine metabolism_Homo sapiens_hsa003400.78213905
59Phototransduction_Homo sapiens_hsa047440.77533747
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.76865987
61Colorectal cancer_Homo sapiens_hsa052100.75747265
62Insulin signaling pathway_Homo sapiens_hsa049100.72327813
63Thyroid hormone synthesis_Homo sapiens_hsa049180.72097633
64Renal cell carcinoma_Homo sapiens_hsa052110.71248374
65Vibrio cholerae infection_Homo sapiens_hsa051100.69632280
66MAPK signaling pathway_Homo sapiens_hsa040100.69530443
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69312750
68Dilated cardiomyopathy_Homo sapiens_hsa054140.68255301
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68029175
70Pancreatic secretion_Homo sapiens_hsa049720.67553753
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67181418
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66747727
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.65095220
74Glucagon signaling pathway_Homo sapiens_hsa049220.64986768
75Ras signaling pathway_Homo sapiens_hsa040140.64887462
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64282657
77Endocytosis_Homo sapiens_hsa041440.62410138
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60590869
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59598220
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59516903
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59291417
82Rap1 signaling pathway_Homo sapiens_hsa040150.58637290
83Non-small cell lung cancer_Homo sapiens_hsa052230.56893515
84Circadian rhythm_Homo sapiens_hsa047100.56382028
85Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55376627
86Butanoate metabolism_Homo sapiens_hsa006500.54094370
87Alcoholism_Homo sapiens_hsa050340.51946140
88Bile secretion_Homo sapiens_hsa049760.51428744
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49831221
90beta-Alanine metabolism_Homo sapiens_hsa004100.49789595
91Wnt signaling pathway_Homo sapiens_hsa043100.48824188
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46805413
93Arginine and proline metabolism_Homo sapiens_hsa003300.46707783
94Prion diseases_Homo sapiens_hsa050200.46466720
95Nitrogen metabolism_Homo sapiens_hsa009100.46061132
96AMPK signaling pathway_Homo sapiens_hsa041520.45544803
97Platelet activation_Homo sapiens_hsa046110.43473296
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.42931972
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42739323
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42666240
101Prolactin signaling pathway_Homo sapiens_hsa049170.41524345
102Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40066201
103Mineral absorption_Homo sapiens_hsa049780.39369005
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38297995
105Inositol phosphate metabolism_Homo sapiens_hsa005620.37438710
106Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37241077
107Chemokine signaling pathway_Homo sapiens_hsa040620.35651603
108Tight junction_Homo sapiens_hsa045300.33903735
109Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.32251247
110Ovarian steroidogenesis_Homo sapiens_hsa049130.30812705
111Fatty acid biosynthesis_Homo sapiens_hsa000610.30489296
112Arginine biosynthesis_Homo sapiens_hsa002200.29607271
113Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.26175185

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