MTRR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. This protein functions in the synthesis of methionine by regenerating methionine synthase to a functional state. Because methionine synthesis requires methyl-group transfer by a folate donor, activity of the encoded enzyme is important for folate metabolism and cellular methylation. Mutations in this gene can cause homocystinuria-megaloblastic anemia, cbl E type. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)5.10848126
2nucleobase biosynthetic process (GO:0046112)4.72620329
3purine nucleobase biosynthetic process (GO:0009113)4.56750749
4nuclear pore organization (GO:0006999)4.52081911
5maturation of SSU-rRNA (GO:0030490)4.48027584
6nuclear pore complex assembly (GO:0051292)4.45031087
7ribosome biogenesis (GO:0042254)4.32051173
8DNA replication checkpoint (GO:0000076)4.23635998
9DNA replication initiation (GO:0006270)4.15106883
10formation of translation preinitiation complex (GO:0001731)4.11376529
11ribonucleoprotein complex biogenesis (GO:0022613)4.06268081
12DNA strand elongation involved in DNA replication (GO:0006271)4.02124173
13mitotic metaphase plate congression (GO:0007080)4.01270915
14mitotic chromosome condensation (GO:0007076)3.98548375
15protein localization to kinetochore (GO:0034501)3.97298372
16regulation of nuclear cell cycle DNA replication (GO:0033262)3.95989843
17ribosomal small subunit biogenesis (GO:0042274)3.88873876
18ribosome assembly (GO:0042255)3.88344276
19mitotic nuclear envelope disassembly (GO:0007077)3.87206316
20ribosomal large subunit biogenesis (GO:0042273)3.86221222
21DNA strand elongation (GO:0022616)3.84455524
22regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.83407647
23telomere maintenance via semi-conservative replication (GO:0032201)3.82170748
24rRNA processing (GO:0006364)3.77539201
25rRNA modification (GO:0000154)3.77223411
26IMP biosynthetic process (GO:0006188)3.73902179
27rRNA metabolic process (GO:0016072)3.68004567
28DNA deamination (GO:0045006)3.62213145
29CENP-A containing nucleosome assembly (GO:0034080)3.57123579
30folic acid-containing compound biosynthetic process (GO:0009396)3.56203715
31non-recombinational repair (GO:0000726)3.54344315
32double-strand break repair via nonhomologous end joining (GO:0006303)3.54344315
33telomere maintenance via recombination (GO:0000722)3.53998767
34chromatin remodeling at centromere (GO:0031055)3.53117493
35membrane disassembly (GO:0030397)3.51975815
36nuclear envelope disassembly (GO:0051081)3.51975815
37sister chromatid segregation (GO:0000819)3.50003653
38pore complex assembly (GO:0046931)3.49811521
39maturation of 5.8S rRNA (GO:0000460)3.45511141
40Golgi transport vesicle coating (GO:0048200)3.45125359
41COPI coating of Golgi vesicle (GO:0048205)3.45125359
42regulation of translation in response to stress (GO:0043555)3.43819286
43transcription elongation from RNA polymerase I promoter (GO:0006362)3.38301609
44spliceosomal snRNP assembly (GO:0000387)3.36710788
45pseudouridine synthesis (GO:0001522)3.36587869
46protein K6-linked ubiquitination (GO:0085020)3.35143494
47tRNA aminoacylation for protein translation (GO:0006418)3.34799399
48termination of RNA polymerase I transcription (GO:0006363)3.34743934
49kinetochore organization (GO:0051383)3.33034145
50spliceosomal tri-snRNP complex assembly (GO:0000244)3.32172834
51mitotic recombination (GO:0006312)3.32078735
52DNA replication-independent nucleosome organization (GO:0034724)3.31203668
53DNA replication-independent nucleosome assembly (GO:0006336)3.31203668
54rRNA methylation (GO:0031167)3.30076540
55positive regulation of chromosome segregation (GO:0051984)3.27517874
56regulation of posttranscriptional gene silencing (GO:0060147)3.27321005
57regulation of gene silencing by miRNA (GO:0060964)3.27321005
58regulation of gene silencing by RNA (GO:0060966)3.27321005
59tRNA aminoacylation (GO:0043039)3.25730939
60amino acid activation (GO:0043038)3.25730939
61protein localization to chromosome, centromeric region (GO:0071459)3.25499335
62regulation of mitotic spindle organization (GO:0060236)3.23761076
63metaphase plate congression (GO:0051310)3.22654456
64ribosomal small subunit assembly (GO:0000028)3.22547346
65nucleotide-excision repair, DNA gap filling (GO:0006297)3.22495238
66DNA replication-dependent nucleosome assembly (GO:0006335)3.22221293
67DNA replication-dependent nucleosome organization (GO:0034723)3.22221293
68cellular protein complex localization (GO:0034629)3.21580324
69nuclear envelope organization (GO:0006998)3.21114347
70IMP metabolic process (GO:0046040)3.20765356
71telomere maintenance via telomere lengthening (GO:0010833)3.20316062
72translational termination (GO:0006415)3.19948866
73regulation of centriole replication (GO:0046599)3.19687270
74termination of RNA polymerase III transcription (GO:0006386)3.19593732
75transcription elongation from RNA polymerase III promoter (GO:0006385)3.19593732
76spliceosomal complex assembly (GO:0000245)3.19543352
77kinetochore assembly (GO:0051382)3.19312474
78DNA unwinding involved in DNA replication (GO:0006268)3.18174044
79transcription from mitochondrial promoter (GO:0006390)3.17397650
80regulation of spindle organization (GO:0090224)3.17155399
81regulation of double-strand break repair via homologous recombination (GO:0010569)3.16388513
82translational initiation (GO:0006413)3.16005097
83regulation of translational fidelity (GO:0006450)3.15526717
84establishment of chromosome localization (GO:0051303)3.15093844
85viral transcription (GO:0019083)3.14099130
86transcription from RNA polymerase I promoter (GO:0006360)3.11310269
87transcription-coupled nucleotide-excision repair (GO:0006283)3.09856985
88maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.08730634
89establishment of integrated proviral latency (GO:0075713)3.04353123
90mitotic sister chromatid segregation (GO:0000070)3.02530540
91COPII vesicle coating (GO:0048208)3.01869318
92mitochondrial RNA metabolic process (GO:0000959)3.01215604
93somatic diversification of immune receptors via somatic mutation (GO:0002566)2.99969704
94somatic hypermutation of immunoglobulin genes (GO:0016446)2.99969704
95tRNA methylation (GO:0030488)2.99313419
96ncRNA processing (GO:0034470)2.98500235
97glutamine metabolic process (GO:0006541)2.97091674
98regulation of chromosome segregation (GO:0051983)2.96849713
99proteasome assembly (GO:0043248)2.96551757
100mitotic spindle checkpoint (GO:0071174)2.95885839
101DNA duplex unwinding (GO:0032508)2.95256321
102DNA geometric change (GO:0032392)2.94871124
103sister chromatid cohesion (GO:0007062)2.94180581
104* folic acid metabolic process (GO:0046655)2.93783445
105replication fork processing (GO:0031297)2.93739684
106regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.91908996
107histone exchange (GO:0043486)2.91187388
108transcription initiation from RNA polymerase I promoter (GO:0006361)2.90763692
109cellular component biogenesis (GO:0044085)2.90677052
110nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.90492128
111negative regulation of chromosome segregation (GO:0051985)2.88253992
112regulation of histone H3-K27 methylation (GO:0061085)2.87760526
113spindle checkpoint (GO:0031577)2.87745860
114ncRNA metabolic process (GO:0034660)2.87572222
115spindle assembly checkpoint (GO:0071173)2.86924869
116positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.86437979
117positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.86437979
118positive regulation of mitotic sister chromatid separation (GO:1901970)2.86437979
119attachment of spindle microtubules to kinetochore (GO:0008608)2.86248554
120viral mRNA export from host cell nucleus (GO:0046784)2.85955143
121translational elongation (GO:0006414)2.85257268
122negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.85126799
123negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.85126799
124negative regulation of mitotic sister chromatid separation (GO:2000816)2.85126799
125negative regulation of sister chromatid segregation (GO:0033046)2.85126799
126DNA-templated transcription, termination (GO:0006353)2.84587436
127mitotic spindle assembly checkpoint (GO:0007094)2.83780601
128protein export from nucleus (GO:0006611)2.83047585
129regulation of centrosome cycle (GO:0046605)2.82076850
130DNA synthesis involved in DNA repair (GO:0000731)2.82019571
131ncRNA catabolic process (GO:0034661)2.81723304
132regulation of mitotic metaphase/anaphase transition (GO:0030071)2.81329190
133protein complex localization (GO:0031503)2.81045372
134meiotic chromosome segregation (GO:0045132)2.80760579
135regulation of centrosome duplication (GO:0010824)2.80400427
136regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.80118983
137negative regulation of mitotic sister chromatid segregation (GO:0033048)2.79481923
138regulation of RNA export from nucleus (GO:0046831)2.77264315
139regulation of translational termination (GO:0006449)2.77247249
140regulation of sister chromatid segregation (GO:0033045)2.75476827
141regulation of mitotic sister chromatid separation (GO:0010965)2.75476827
142regulation of mitotic sister chromatid segregation (GO:0033047)2.75476827
143DNA conformation change (GO:0071103)2.70883036
144anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.70815835
145positive regulation of protein import into nucleus, translocation (GO:0033160)2.68939296
146regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.68514048
147negative regulation of DNA repair (GO:0045738)2.68154666
148mRNA transport (GO:0051028)2.58759079
149nucleobase-containing small molecule interconversion (GO:0015949)2.58367086
150chromosome condensation (GO:0030261)2.58305698
151DNA packaging (GO:0006323)2.58190386
152tricarboxylic acid cycle (GO:0006099)2.57840843
153cell cycle G1/S phase transition (GO:0044843)2.56547323
154G1/S transition of mitotic cell cycle (GO:0000082)2.56547323
155positive regulation of viral genome replication (GO:0045070)2.54862790

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.96638136
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.52058944
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.65170500
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.33542350
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.26811375
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.20247353
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.12544684
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.11580188
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.06368599
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.05143853
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.98611001
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.94166527
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.93983583
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.90670839
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.70098528
16VDR_23849224_ChIP-Seq_CD4+_Human2.38554150
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.37596534
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.34537641
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33545588
20FOXP3_21729870_ChIP-Seq_TREG_Human2.20205233
21XRN2_22483619_ChIP-Seq_HELA_Human2.18587928
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.13724316
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.12375493
24MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.09596989
25GATA1_22025678_ChIP-Seq_K562_Human2.09531494
26* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.09189947
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.08465092
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.07276246
29DCP1A_22483619_ChIP-Seq_HELA_Human2.04949896
30KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.04356340
31KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.04356340
32KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.04356340
33E2F1_18555785_ChIP-Seq_MESCs_Mouse2.04058325
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.03467175
35* MYCN_18555785_ChIP-Seq_MESCs_Mouse2.02066614
36PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.97755300
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.92130423
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.91912584
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.88393289
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.85296583
41TTF2_22483619_ChIP-Seq_HELA_Human1.82610323
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.81337030
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78646698
44GABP_19822575_ChIP-Seq_HepG2_Human1.78068568
45SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.76887037
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.76744387
47AR_21909140_ChIP-Seq_LNCAP_Human1.74314043
48ELK1_19687146_ChIP-ChIP_HELA_Human1.73350859
49SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.73119530
50* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73119131
51EGR1_19374776_ChIP-ChIP_THP-1_Human1.71942269
52FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.69601521
53ELF1_17652178_ChIP-ChIP_JURKAT_Human1.65352335
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.64595022
55* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64205891
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.57543367
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53441432
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.50133210
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.48414425
60* KDM5A_27292631_Chip-Seq_BREAST_Human1.47019191
61POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.45486670
62SALL1_21062744_ChIP-ChIP_HESCs_Human1.45108090
63TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45074928
64MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40502496
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.40095909
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36765294
67HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33226008
68SOX2_18555785_ChIP-Seq_MESCs_Mouse1.32729349
69TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.31833239
70CIITA_25753668_ChIP-Seq_RAJI_Human1.30888893
71NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.28567796
72CLOCK_20551151_ChIP-Seq_293T_Human1.27361551
73SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.26880843
74MYB_21317192_ChIP-Seq_ERMYB_Mouse1.26220545
75FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.25212200
76SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23487493
77RBPJ_22232070_ChIP-Seq_NCS_Mouse1.22900244
78MYC_22102868_ChIP-Seq_BL_Human1.22743314
79ZNF263_19887448_ChIP-Seq_K562_Human1.22740209
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22721109
81SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.22338779
82TFEB_21752829_ChIP-Seq_HELA_Human1.20682716
83KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.19527781
84ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17163542
85PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16917490
86KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16196734
87CHD1_26751641_Chip-Seq_LNCaP_Human1.15357499
88ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12268737
89BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09662805
90TCF3_18692474_ChIP-Seq_MEFs_Mouse1.09070944
91HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07776615
92NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.06664682
93* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05497881
94E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04025145
95CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03242905
96* MYB_26560356_Chip-Seq_TH2_Human1.02847410
97EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.02742312
98CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.02483077
99FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01341078
100NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00219306
101CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99976396
102PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.99248994
103TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.98902398
104BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98417549
105MYB_26560356_Chip-Seq_TH1_Human0.98111232
106CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97908022
107TCF3_18692474_ChIP-Seq_MESCs_Mouse0.97212508
108STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97123079
109NANOG_21062744_ChIP-ChIP_HESCs_Human0.97085907
110ELK1_22589737_ChIP-Seq_MCF10A_Human0.95525281
111CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95284709
112HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94538463
113SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.94168579
114IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.93676176
115HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.93301320
116NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.93161135
117ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93014773
118MYC_18940864_ChIP-ChIP_HL60_Human0.92902297
119GATA4_21415370_ChIP-Seq_HL-1_Mouse0.91257018
120SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.90442032
121SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.90442032
122CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.89666435
123SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.89209353
124KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88812593
125* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.86175112
126GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86063944
127STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.84530563
128SOX17_20123909_ChIP-Seq_XEN_Mouse0.83494338
129POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.81003211
130OCT4_18692474_ChIP-Seq_MEFs_Mouse0.80191924

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.14706860
2MP0008057_abnormal_DNA_replication4.56269495
3MP0003111_abnormal_nucleus_morphology4.55914139
4MP0010094_abnormal_chromosome_stability4.48747877
5MP0004957_abnormal_blastocyst_morpholog4.20274347
6MP0003077_abnormal_cell_cycle3.66328526
7MP0008058_abnormal_DNA_repair3.61358537
8MP0008932_abnormal_embryonic_tissue2.82693437
9MP0004233_abnormal_muscle_weight2.77162381
10MP0008007_abnormal_cellular_replicative2.70433822
11MP0002877_abnormal_melanocyte_morpholog2.65340514
12MP0006292_abnormal_olfactory_placode2.50428800
13MP0003786_premature_aging2.31198047
14MP0002009_preneoplasia2.25919911
15MP0000350_abnormal_cell_proliferation2.14687917
16MP0001730_embryonic_growth_arrest2.12612758
17MP0002396_abnormal_hematopoietic_system2.08799207
18MP0005451_abnormal_body_composition1.99833459
19MP0003123_paternal_imprinting1.98447206
20MP0002166_altered_tumor_susceptibility1.95916451
21MP0001661_extended_life_span1.94254906
22MP0005380_embryogenesis_phenotype1.88476331
23MP0001672_abnormal_embryogenesis/_devel1.88476331
24MP0010234_abnormal_vibrissa_follicle1.87392692
25MP0003718_maternal_effect1.84960939
26MP0003890_abnormal_embryonic-extraembry1.81781956
27MP0008877_abnormal_DNA_methylation1.78103729
28MP0010307_abnormal_tumor_latency1.69883004
29MP0003136_yellow_coat_color1.65145269
30MP0010352_gastrointestinal_tract_polyps1.64111731
31MP0003984_embryonic_growth_retardation1.62712438
32MP0001697_abnormal_embryo_size1.62511701
33MP0001293_anophthalmia1.60972674
34MP0002088_abnormal_embryonic_growth/wei1.60778414
35MP0000490_abnormal_crypts_of1.60083293
36MP0003941_abnormal_skin_development1.53887801
37MP0002085_abnormal_embryonic_tissue1.51065794
38MP0009333_abnormal_splenocyte_physiolog1.50046429
39MP0002080_prenatal_lethality1.50002171
40MP0002006_tumorigenesis1.47219036
41MP0002086_abnormal_extraembryonic_tissu1.45808511
42MP0005408_hypopigmentation1.43485475
43MP0002277_abnormal_respiratory_mucosa1.42448983
44MP0000372_irregular_coat_pigmentation1.39742689
45MP0002084_abnormal_developmental_patter1.38399748
46MP0000313_abnormal_cell_death1.37596149
47MP0004808_abnormal_hematopoietic_stem1.34594470
48MP0003950_abnormal_plasma_membrane1.34374436
49MP0004197_abnormal_fetal_growth/weight/1.34018809
50MP0010030_abnormal_orbit_morphology1.33083972
51MP0002269_muscular_atrophy1.32617924
52MP0004185_abnormal_adipocyte_glucose1.32428680
53MP0010678_abnormal_skin_adnexa1.27722024
54MP0003763_abnormal_thymus_physiology1.26993886
55MP0002019_abnormal_tumor_incidence1.25372060
56MP0003567_abnormal_fetal_cardiomyocyte1.21952200
57MP0003121_genomic_imprinting1.21001381
58MP0003566_abnormal_cell_adhesion1.20243477
59MP0003656_abnormal_erythrocyte_physiolo1.19001831
60MP0005389_reproductive_system_phenotype1.16653756
61MP0004036_abnormal_muscle_relaxation1.16180718
62MP0003646_muscle_fatigue1.13240522
63MP0000703_abnormal_thymus_morphology1.09734031
64MP0003221_abnormal_cardiomyocyte_apopto1.09542295
65MP0005075_abnormal_melanosome_morpholog1.09224449
66MP0002210_abnormal_sex_determination1.08496478
67MP0001919_abnormal_reproductive_system1.07957343
68MP0009697_abnormal_copulation1.07614108
69MP0002160_abnormal_reproductive_system1.06478860
70MP0001188_hyperpigmentation1.05975935
71MP0005330_cardiomyopathy1.05289299
72MP0006036_abnormal_mitochondrial_physio1.04277003
73MP0005083_abnormal_biliary_tract1.04214700
74MP0003453_abnormal_keratinocyte_physiol1.03776175
75MP0001145_abnormal_male_reproductive0.98525730
76MP0002132_abnormal_respiratory_system0.97520647
77MP0000749_muscle_degeneration0.97501737
78MP0004264_abnormal_extraembryonic_tissu0.97029330
79MP0000383_abnormal_hair_follicle0.95053443
80MP0002796_impaired_skin_barrier0.94545925
81MP0004782_abnormal_surfactant_physiolog0.94356319
82MP0004133_heterotaxia0.93555148
83MP0004084_abnormal_cardiac_muscle0.92088367
84MP0000689_abnormal_spleen_morphology0.92062774
85MP0008260_abnormal_autophagy0.91895165
86MP0002722_abnormal_immune_system0.91117610
87MP0002398_abnormal_bone_marrow0.90487856
88MP0001853_heart_inflammation0.88517611
89MP0004087_abnormal_muscle_fiber0.88063155
90MP0001545_abnormal_hematopoietic_system0.87218352
91MP0005397_hematopoietic_system_phenotyp0.87218352
92MP0002970_abnormal_white_adipose0.86863601
93MP0005501_abnormal_skin_physiology0.85656012
94MP0002938_white_spotting0.85507789
95MP0000358_abnormal_cell_content/0.84712533
96MP0005171_absent_coat_pigmentation0.84186965
97MP0009115_abnormal_fat_cell0.83768763
98MP0009703_decreased_birth_body0.82957675
99MP0002111_abnormal_tail_morphology0.81305720
100MP0004381_abnormal_hair_follicle0.81208012
101MP0002092_abnormal_eye_morphology0.81018335
102MP0001286_abnormal_eye_development0.80612199
103MP0000003_abnormal_adipose_tissue0.80006945
104MP0003119_abnormal_digestive_system0.79720436
105MP0000653_abnormal_sex_gland0.79166483
106MP0003806_abnormal_nucleotide_metabolis0.78800689
107MP0003943_abnormal_hepatobiliary_system0.77518043
108MP0002060_abnormal_skin_morphology0.77382343
109MP0000432_abnormal_head_morphology0.76601685
110MP0000759_abnormal_skeletal_muscle0.76570274
111MP0005384_cellular_phenotype0.76217685
112MP0001216_abnormal_epidermal_layer0.75256456
113MP0003937_abnormal_limbs/digits/tail_de0.73614668
114MP0001929_abnormal_gametogenesis0.73354097
115MP0000015_abnormal_ear_pigmentation0.73117191
116MP0005266_abnormal_metabolism0.72602660
117MP0006138_congestive_heart_failure0.72581663
118MP0002075_abnormal_coat/hair_pigmentati0.70869737
119MP0001186_pigmentation_phenotype0.70845680
120MP0002971_abnormal_brown_adipose0.70053223
121MP0000858_altered_metastatic_potential0.69895679
122MP0001243_abnormal_dermal_layer0.69765250
123MP0000747_muscle_weakness0.68543861
124MP0003186_abnormal_redox_activity0.67780665
125MP0005621_abnormal_cell_physiology0.67746915
126MP0000750_abnormal_muscle_regeneration0.67624659
127MP0005666_abnormal_adipose_tissue0.67597990
128MP0003315_abnormal_perineum_morphology0.67305661
129MP0006035_abnormal_mitochondrial_morpho0.67213366
130MP0002332_abnormal_exercise_endurance0.67162370
131MP0005623_abnormal_meninges_morphology0.66993571
132MP0002429_abnormal_blood_cell0.66823460
133MP0010630_abnormal_cardiac_muscle0.66219420
134MP0000428_abnormal_craniofacial_morphol0.64114449
135MP0005076_abnormal_cell_differentiation0.63528233
136MP0003936_abnormal_reproductive_system0.63173111
137MP0001119_abnormal_female_reproductive0.63132553
138MP0003787_abnormal_imprinting0.62127402
139MP0001915_intracranial_hemorrhage0.60906950
140MP0000371_diluted_coat_color0.60865344
141MP0002095_abnormal_skin_pigmentation0.60377883
142MP0009672_abnormal_birth_weight0.60208773
143MP0009278_abnormal_bone_marrow0.59487853
144MP0000516_abnormal_urinary_system0.59187708
145MP0005367_renal/urinary_system_phenotyp0.59187708
146MP0001542_abnormal_bone_strength0.59037987
147MP0008789_abnormal_olfactory_epithelium0.58616932
148MP0009379_abnormal_foot_pigmentation0.58141264
149MP0000733_abnormal_muscle_development0.56797992
150MP0002653_abnormal_ependyma_morphology0.55335530

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.70017285
2Birth length less than 3rd percentile (HP:0003561)4.57866945
3Breast hypoplasia (HP:0003187)4.57019202
4Chromsome breakage (HP:0040012)4.54269058
5Absent radius (HP:0003974)3.73358086
6Aplasia involving forearm bones (HP:0009822)3.50709550
7Absent forearm bone (HP:0003953)3.50709550
8Reticulocytopenia (HP:0001896)3.50621433
9Patellar aplasia (HP:0006443)3.41426312
10Aplasia/Hypoplasia of the patella (HP:0006498)3.19322067
11Exercise-induced muscle cramps (HP:0003710)3.18512994
12Abnormality of chromosome stability (HP:0003220)3.16094763
13Nemaline bodies (HP:0003798)3.15944910
14Meckel diverticulum (HP:0002245)3.14432823
15Impulsivity (HP:0100710)3.13242891
16Cerebral hypomyelination (HP:0006808)3.10480615
17Hypokinesia (HP:0002375)3.08888013
18Abnormality of the preputium (HP:0100587)3.07565409
19Aplasia/Hypoplasia of the uvula (HP:0010293)3.06368258
20Abnormality of the ileum (HP:0001549)3.06122595
21Insidious onset (HP:0003587)3.03056055
22Termporal pattern (HP:0011008)3.03056055
23Fatigue (HP:0012378)3.02462151
24Abnormality of cells of the erythroid lineage (HP:0012130)2.99946505
25Submucous cleft hard palate (HP:0000176)2.98163294
26Selective tooth agenesis (HP:0001592)2.91316736
27Rough bone trabeculation (HP:0100670)2.90445242
28Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.90030425
29Muscle fiber inclusion bodies (HP:0100299)2.89001506
30Myelodysplasia (HP:0002863)2.85629265
31Deep philtrum (HP:0002002)2.83967215
32Abnormality of DNA repair (HP:0003254)2.82871316
33Abnormality of glycolysis (HP:0004366)2.80357099
34Degeneration of anterior horn cells (HP:0002398)2.79268607
35Abnormality of the anterior horn cell (HP:0006802)2.79268607
36Absent thumb (HP:0009777)2.76261386
37Osteolytic defects of the phalanges of the hand (HP:0009771)2.71225956
38Osteolytic defects of the hand bones (HP:0009699)2.71225956
39Duplicated collecting system (HP:0000081)2.70388423
40Entropion (HP:0000621)2.68717719
41Progressive external ophthalmoplegia (HP:0000590)2.65461380
42Prominent nose (HP:0000448)2.65227146
43Abnormal auditory evoked potentials (HP:0006958)2.65039793
44Abnormal number of erythroid precursors (HP:0012131)2.64919946
45Ragged-red muscle fibers (HP:0003200)2.64371603
46Cutaneous melanoma (HP:0012056)2.64243274
47Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.62652157
48Abnormality of the labia minora (HP:0012880)2.61767484
49Autoamputation (HP:0001218)2.59548061
50Rhabdomyosarcoma (HP:0002859)2.56522701
51Triphalangeal thumb (HP:0001199)2.53864816
52Aplasia/hypoplasia of the humerus (HP:0006507)2.53208823
53Medulloblastoma (HP:0002885)2.52568674
54Ankyloglossia (HP:0010296)2.49014683
55Premature graying of hair (HP:0002216)2.47618230
56Bone marrow hypocellularity (HP:0005528)2.46963227
57Ependymoma (HP:0002888)2.46633536
58Small intestinal stenosis (HP:0012848)2.44016534
59Duodenal stenosis (HP:0100867)2.44016534
60Facial cleft (HP:0002006)2.43670377
61Fibular aplasia (HP:0002990)2.43667994
62Increased serum pyruvate (HP:0003542)2.43631475
63Acute myeloid leukemia (HP:0004808)2.43536122
64Pallor (HP:0000980)2.42050421
65Supernumerary spleens (HP:0009799)2.41617867
66Ureteral duplication (HP:0000073)2.41561117
67Reduced antithrombin III activity (HP:0001976)2.38096083
68Myoglobinuria (HP:0002913)2.37228564
69Abnormality of the renal collecting system (HP:0004742)2.36287840
70Basal cell carcinoma (HP:0002671)2.35460573
71Rhabdomyolysis (HP:0003201)2.33888438
72Abnormal trabecular bone morphology (HP:0100671)2.29774119
73* Macrocytic anemia (HP:0001972)2.25577514
74Absent hand (HP:0004050)2.25372543
75Hypobetalipoproteinemia (HP:0003563)2.24685985
76Abnormality of oral frenula (HP:0000190)2.24344893
77Agnosia (HP:0010524)2.24342062
78Sloping forehead (HP:0000340)2.22627312
79Trismus (HP:0000211)2.21698065
80Squamous cell carcinoma (HP:0002860)2.21430559
81Horizontal nystagmus (HP:0000666)2.20765733
82Increased nuchal translucency (HP:0010880)2.20067113
83Rib fusion (HP:0000902)2.19306216
84Sparse lateral eyebrow (HP:0005338)2.17705678
85Exercise-induced myalgia (HP:0003738)2.17338634
86Ectopic kidney (HP:0000086)2.16592503
87Oral leukoplakia (HP:0002745)2.16163777
88Short humerus (HP:0005792)2.15746009
89Aplasia/Hypoplasia of the sacrum (HP:0008517)2.14593892
90Poikiloderma (HP:0001029)2.13439071
91Overlapping toe (HP:0001845)2.13428366
92Horseshoe kidney (HP:0000085)2.12311226
9311 pairs of ribs (HP:0000878)2.10743675
94Neoplasm of the pancreas (HP:0002894)2.10285669
95Impaired pain sensation (HP:0007328)2.09450275
96Abnormality of pain sensation (HP:0010832)2.09450275
97Reduced subcutaneous adipose tissue (HP:0003758)2.08784525
98Carpal bone hypoplasia (HP:0001498)2.08426449
99Freckling (HP:0001480)2.08352997
100Abnormality of the duodenum (HP:0002246)2.07843518
101Aplastic anemia (HP:0001915)2.07386079
102Cortical dysplasia (HP:0002539)2.06860476
103Impaired proprioception (HP:0010831)2.06242710
104Lymphoma (HP:0002665)2.04223890
105Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.03907265
106Abnormal protein N-linked glycosylation (HP:0012347)2.03907265
107Abnormal protein glycosylation (HP:0012346)2.03907265
108Abnormal glycosylation (HP:0012345)2.03907265
109Abnormal number of incisors (HP:0011064)2.03478106
110Relative macrocephaly (HP:0004482)2.03351696
111Type I transferrin isoform profile (HP:0003642)2.03046738
112Progressive muscle weakness (HP:0003323)2.01765388
113Breast aplasia (HP:0100783)2.01196631
114Autoimmune hemolytic anemia (HP:0001890)2.01131681
115Abnormal hemoglobin (HP:0011902)1.99616764
116Missing ribs (HP:0000921)1.98835302
117Abnormality of the umbilical cord (HP:0010881)1.97810384
118Shoulder girdle muscle weakness (HP:0003547)1.97227856
119Duplication of thumb phalanx (HP:0009942)1.95471064
120Hypoplasia of the radius (HP:0002984)1.95154453
121Glioma (HP:0009733)1.94727414
122Papillary thyroid carcinoma (HP:0002895)1.92923374
123Tracheoesophageal fistula (HP:0002575)1.92150848
124Abnormal lung lobation (HP:0002101)1.91937445
125Centrally nucleated skeletal muscle fibers (HP:0003687)1.91638401
126Aplasia/Hypoplasia involving the musculature (HP:0001460)1.91602758
127Prominent metopic ridge (HP:0005487)1.90852691
128Short thumb (HP:0009778)1.89441271
129Deviation of the thumb (HP:0009603)1.89315980
130Atresia of the external auditory canal (HP:0000413)1.88626632
131Neoplasm of the rectum (HP:0100743)1.84796470
132EMG: myopathic abnormalities (HP:0003458)1.84731012
133Abnormality of the left ventricular outflow tract (HP:0011103)1.84682039
134Subaortic stenosis (HP:0001682)1.84682039
135Progressive hearing impairment (HP:0001730)1.84167113
136Embryonal renal neoplasm (HP:0011794)1.83800873
137Supernumerary bones of the axial skeleton (HP:0009144)1.83783037
138Aplasia/Hypoplasia of the breasts (HP:0010311)1.83412638
139Hypergonadotropic hypogonadism (HP:0000815)1.83083384
140Neoplasm of the small intestine (HP:0100833)1.83061413
141Urethral obstruction (HP:0000796)1.82829655
142Cleft eyelid (HP:0000625)1.82508457
143Colon cancer (HP:0003003)1.82340441
144Proximal placement of thumb (HP:0009623)1.81740577
145Median cleft lip (HP:0000161)1.81534710
146Upper limb muscle weakness (HP:0003484)1.81405821
147Multiple enchondromatosis (HP:0005701)1.81333080
148Glucose intolerance (HP:0000833)1.80013892
149Slender long bone (HP:0003100)1.79508930
150Nephroblastoma (Wilms tumor) (HP:0002667)1.79095067
151Abnormality of the astrocytes (HP:0100707)1.78042117
152Astrocytoma (HP:0009592)1.78042117
153Secondary amenorrhea (HP:0000869)1.77748506
154Tongue fasciculations (HP:0001308)1.77139871
155Neck muscle weakness (HP:0000467)1.76669406
156Tetraparesis (HP:0002273)1.76514049
157Clubbing of toes (HP:0100760)1.75129837
158Spastic diplegia (HP:0001264)1.75109625
159Dysmetric saccades (HP:0000641)1.74636666
160Septate vagina (HP:0001153)1.74347214
161Areflexia of lower limbs (HP:0002522)1.74031991
162Hypochromic anemia (HP:0001931)1.72342325
163Increased connective tissue (HP:0009025)1.71657295
164Microvesicular hepatic steatosis (HP:0001414)1.71630509
165Orthostatic hypotension (HP:0001278)1.71331310
166Pancreatic fibrosis (HP:0100732)1.71241534
167Cafe-au-lait spot (HP:0000957)1.70457478
168Spinal muscular atrophy (HP:0007269)1.70341248
169Stillbirth (HP:0003826)1.70233607
170Sparse eyelashes (HP:0000653)1.69243364
171Dyschromatopsia (HP:0007641)1.68694147
172Menstrual irregularities (HP:0000858)1.68313672
173Abnormality of the intrinsic pathway (HP:0010989)1.68233261
174Pelvic girdle muscle weakness (HP:0003749)1.67387192
175Neoplasm of the colon (HP:0100273)1.66924922
176Resting tremor (HP:0002322)1.65319003

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.41894187
2SRPK14.19148754
3WEE13.74092224
4PLK43.39257491
5PDK23.24724903
6PBK3.12308098
7EIF2AK12.92398310
8CDC72.91163805
9MST1R2.79581313
10STK162.69592457
11NEK22.49988804
12TTK2.48774973
13AKT32.46392771
14MST42.43418824
15EPHA22.30635549
16TSSK62.29753741
17TLK12.15710204
18MKNK22.11067287
19ZAK2.10180538
20NME21.98079036
21PLK11.91503468
22VRK11.85163520
23CDK71.78843053
24CDK121.76204758
25MKNK11.75926928
26TRIM281.68474747
27DYRK31.65249239
28PLK31.57802165
29TAOK21.55824970
30MET1.53795476
31ATR1.49844406
32RPS6KB21.49555181
33EIF2AK31.45730210
34CHEK21.44947808
35ERBB31.39196836
36ACVR1B1.37596398
37PIM11.36897329
38AURKB1.31932265
39BRSK21.29428147
40AURKA1.29194424
41SIK31.25027682
42MELK1.22670334
43PIM21.19889596
44MAP3K81.19524733
45CHEK11.19477129
46STK101.19357023
47PAK41.15014304
48PNCK1.10935543
49CDK41.09682916
50NEK61.08875851
51BMPR21.08102131
52TTN1.06459725
53BRAF1.03214730
54RPS6KA41.02123944
55NEK11.01620802
56IRAK21.00033395
57BRD40.97892693
58EIF2AK20.95447233
59CAMKK20.95211664
60BRSK10.92645264
61MAP3K140.91322497
62ERBB40.90952111
63ATM0.90498641
64PASK0.89668754
65CDK20.83135780
66STK40.81939855
67MAPK110.80550129
68OBSCN0.80478247
69ALK0.80021918
70IKBKB0.79480522
71RAF10.78933365
72MAP4K10.77345795
73IRAK10.74507151
74MAP3K50.74451308
75CSNK2A20.72749600
76ICK0.71782178
77NEK90.70849310
78PRKCI0.68592126
79RPS6KA50.68170770
80NME10.67676227
81CSNK2A10.67582674
82DYRK20.66837022
83JAK10.66120230
84TRPM70.65794753
85STK30.65495220
86YES10.65375925
87TXK0.61328034
88LATS10.60714929
89PIK3CG0.60682152
90IRAK30.59689839
91PAK10.58440473
92CDK10.56971593
93BLK0.55937336
94CAMK1G0.55308240
95CDK60.54343983
96CAMK1D0.53717576
97KSR20.53368498
98AKT20.52468747
99CDK80.52168804
100FGFR10.52038186
101EEF2K0.51735871
102PINK10.49270906
103MAP3K120.49123882
104FGFR30.47976003
105STK38L0.47605259
106MAP3K20.46868442
107MAP2K30.44574494
108LATS20.43693383
109FER0.43377191
110STK240.41377625
111MAP3K130.41350621
112PRPF4B0.40868726
113TGFBR20.40523544
114CSNK1E0.40488391
115TYK20.40205344
116CCNB10.39554428
117FLT30.39283193
118ABL20.37520054
119MAP3K90.36051643
120MAPK100.35683831
121PDGFRA0.34066245
122CHUK0.33938139
123MTOR0.33215848
124PRKAA20.31341463
125MAP3K100.31287131
126TESK20.30112547
127PRKDC0.29639885
128CLK10.29565944
129FGFR40.29251022
130SCYL20.28921957
131RPS6KB10.27456390
132CSF1R0.27301294
133NLK0.27021527
134LYN0.25921466
135GRK60.25728497
136MAPK140.23784101
137ZAP700.23130207
138TEC0.23060601
139PAK20.22245519
140TGFBR10.22085907
141MARK30.21950632
142IRAK40.21828588
143MAP3K110.21796149
144JAK30.21308765

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.21142363
2DNA replication_Homo sapiens_hsa030304.06812387
3Mismatch repair_Homo sapiens_hsa034303.79926580
4RNA polymerase_Homo sapiens_hsa030203.66644975
5Ribosome_Homo sapiens_hsa030103.32208199
6RNA transport_Homo sapiens_hsa030133.19434586
7Spliceosome_Homo sapiens_hsa030403.10687956
8Nucleotide excision repair_Homo sapiens_hsa034203.00652904
9Homologous recombination_Homo sapiens_hsa034402.95490096
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.84267435
11Proteasome_Homo sapiens_hsa030502.80092567
12One carbon pool by folate_Homo sapiens_hsa006702.76113243
13Base excision repair_Homo sapiens_hsa034102.74581096
14Fanconi anemia pathway_Homo sapiens_hsa034602.67368967
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.58760314
16Vitamin B6 metabolism_Homo sapiens_hsa007502.49871713
17Cell cycle_Homo sapiens_hsa041102.41358264
18Pyrimidine metabolism_Homo sapiens_hsa002402.38299788
19RNA degradation_Homo sapiens_hsa030182.07091611
20Basal transcription factors_Homo sapiens_hsa030222.04798640
21Non-homologous end-joining_Homo sapiens_hsa034501.95678251
22mRNA surveillance pathway_Homo sapiens_hsa030151.76401856
23p53 signaling pathway_Homo sapiens_hsa041151.60887295
24Carbon metabolism_Homo sapiens_hsa012001.54352276
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49568344
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.40905620
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.33254396
28Purine metabolism_Homo sapiens_hsa002301.32949526
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.23652291
30Propanoate metabolism_Homo sapiens_hsa006401.18024753
31Circadian rhythm_Homo sapiens_hsa047101.16710549
32N-Glycan biosynthesis_Homo sapiens_hsa005101.16656212
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.13733502
34Pyruvate metabolism_Homo sapiens_hsa006201.13163729
35Epstein-Barr virus infection_Homo sapiens_hsa051691.12020715
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09635427
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.05058369
38Central carbon metabolism in cancer_Homo sapiens_hsa052301.02583922
39Arginine biosynthesis_Homo sapiens_hsa002201.01299506
40Folate biosynthesis_Homo sapiens_hsa007900.98227012
41Systemic lupus erythematosus_Homo sapiens_hsa053220.96027517
42Herpes simplex infection_Homo sapiens_hsa051680.94480611
43Pancreatic cancer_Homo sapiens_hsa052120.88679762
44Protein export_Homo sapiens_hsa030600.88574124
45Non-small cell lung cancer_Homo sapiens_hsa052230.85476685
46Viral carcinogenesis_Homo sapiens_hsa052030.84980310
47Lysine degradation_Homo sapiens_hsa003100.84687215
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.82053002
49Fatty acid elongation_Homo sapiens_hsa000620.77231895
50Primary immunodeficiency_Homo sapiens_hsa053400.76040699
51Antigen processing and presentation_Homo sapiens_hsa046120.75806907
52Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74133584
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.65838852
54Oocyte meiosis_Homo sapiens_hsa041140.64572647
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64049563
56HTLV-I infection_Homo sapiens_hsa051660.63613218
57Biosynthesis of amino acids_Homo sapiens_hsa012300.63238492
58Selenocompound metabolism_Homo sapiens_hsa004500.62460740
59NF-kappa B signaling pathway_Homo sapiens_hsa040640.61837427
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.61554627
61Pentose phosphate pathway_Homo sapiens_hsa000300.61491080
62MicroRNAs in cancer_Homo sapiens_hsa052060.59743708
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.58784112
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58633829
65Regulation of autophagy_Homo sapiens_hsa041400.57893338
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56886966
67Thyroid cancer_Homo sapiens_hsa052160.55916195
68Insulin signaling pathway_Homo sapiens_hsa049100.53548770
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53170856
70Fructose and mannose metabolism_Homo sapiens_hsa000510.53146923
71Small cell lung cancer_Homo sapiens_hsa052220.52694217
72mTOR signaling pathway_Homo sapiens_hsa041500.51954243
73Glucagon signaling pathway_Homo sapiens_hsa049220.51796850
74FoxO signaling pathway_Homo sapiens_hsa040680.51638691
75Renal cell carcinoma_Homo sapiens_hsa052110.51434003
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50371967
77Legionellosis_Homo sapiens_hsa051340.50244815
78Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50005342
79Sulfur relay system_Homo sapiens_hsa041220.48726917
80Fatty acid metabolism_Homo sapiens_hsa012120.48720038
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48321746
82Measles_Homo sapiens_hsa051620.48316715
83Apoptosis_Homo sapiens_hsa042100.47673284
84Sulfur metabolism_Homo sapiens_hsa009200.46360267
85Endometrial cancer_Homo sapiens_hsa052130.45315850
86Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44614069
87Fatty acid biosynthesis_Homo sapiens_hsa000610.44124382
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44028081
89Shigellosis_Homo sapiens_hsa051310.43337474
90Insulin resistance_Homo sapiens_hsa049310.41628042
91Arginine and proline metabolism_Homo sapiens_hsa003300.41495367
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41050056
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40708764
94Inositol phosphate metabolism_Homo sapiens_hsa005620.40560575
95Galactose metabolism_Homo sapiens_hsa000520.39907161
96Glioma_Homo sapiens_hsa052140.38897254
97TGF-beta signaling pathway_Homo sapiens_hsa043500.38209222
98Renin-angiotensin system_Homo sapiens_hsa046140.37972404
99Allograft rejection_Homo sapiens_hsa053300.35784637
100Hematopoietic cell lineage_Homo sapiens_hsa046400.35569263
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35441380
102Hepatitis B_Homo sapiens_hsa051610.35179665
103Acute myeloid leukemia_Homo sapiens_hsa052210.34603097
104Proteoglycans in cancer_Homo sapiens_hsa052050.34383021
105TNF signaling pathway_Homo sapiens_hsa046680.33067520
106Intestinal immune network for IgA production_Homo sapiens_hsa046720.32753756
107Arachidonic acid metabolism_Homo sapiens_hsa005900.31817171
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31320685
109Glutathione metabolism_Homo sapiens_hsa004800.30779463
110NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30158775
111Prostate cancer_Homo sapiens_hsa052150.29673981
112Hippo signaling pathway_Homo sapiens_hsa043900.27956102
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27335210
114Linoleic acid metabolism_Homo sapiens_hsa005910.26573783
115Chronic myeloid leukemia_Homo sapiens_hsa052200.24636311
116Graft-versus-host disease_Homo sapiens_hsa053320.24008594
117Metabolic pathways_Homo sapiens_hsa011000.22072037
118Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.21238351
119Notch signaling pathway_Homo sapiens_hsa043300.21212522
120Viral myocarditis_Homo sapiens_hsa054160.21086405
121Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19663931
122Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.19650387
123Autoimmune thyroid disease_Homo sapiens_hsa053200.19545787
124Vitamin digestion and absorption_Homo sapiens_hsa049770.19131078
125Bladder cancer_Homo sapiens_hsa052190.18396088
126Huntingtons disease_Homo sapiens_hsa050160.18384032
127T cell receptor signaling pathway_Homo sapiens_hsa046600.17646516
128Pathways in cancer_Homo sapiens_hsa052000.17231243
129Influenza A_Homo sapiens_hsa051640.16595398
130Jak-STAT signaling pathway_Homo sapiens_hsa046300.15553627
131HIF-1 signaling pathway_Homo sapiens_hsa040660.15090925
132Melanoma_Homo sapiens_hsa052180.14985469
133Adherens junction_Homo sapiens_hsa045200.13763274
134Hedgehog signaling pathway_Homo sapiens_hsa043400.11868863
135Alcoholism_Homo sapiens_hsa050340.11721485
136Colorectal cancer_Homo sapiens_hsa052100.11270480
137PI3K-Akt signaling pathway_Homo sapiens_hsa041510.10529375

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