MTRNR2L5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)6.25869378
2behavioral response to nicotine (GO:0035095)6.11638816
3nonmotile primary cilium assembly (GO:0035058)3.91559649
4preassembly of GPI anchor in ER membrane (GO:0016254)3.89111643
5regulation of cilium movement (GO:0003352)3.59775842
6negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.49129513
7synaptic transmission, cholinergic (GO:0007271)3.43850502
8protein polyglutamylation (GO:0018095)3.39905370
9negative regulation of transcription regulatory region DNA binding (GO:2000678)3.39363180
10cell proliferation in forebrain (GO:0021846)3.37629480
11negative regulation of telomere maintenance (GO:0032205)3.35866429
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.27092627
13positive regulation of sodium ion transmembrane transport (GO:1902307)3.25518460
14protein localization to cilium (GO:0061512)3.23767479
15pyrimidine nucleobase catabolic process (GO:0006208)3.17277271
16detection of light stimulus involved in sensory perception (GO:0050962)3.15190406
17detection of light stimulus involved in visual perception (GO:0050908)3.15190406
18sperm motility (GO:0030317)3.13760914
19DNA deamination (GO:0045006)3.13517042
20neuronal action potential (GO:0019228)3.07537980
21negative regulation of appetite (GO:0032099)2.99754034
22negative regulation of response to food (GO:0032096)2.99754034
23auditory receptor cell differentiation (GO:0042491)2.99662251
24energy coupled proton transport, down electrochemical gradient (GO:0015985)2.98905342
25ATP synthesis coupled proton transport (GO:0015986)2.98905342
26mitochondrial calcium ion transport (GO:0006851)2.97985968
27membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.96560829
28regulation of female receptivity (GO:0045924)2.95683488
29neuronal action potential propagation (GO:0019227)2.95535724
30membrane depolarization during action potential (GO:0086010)2.94982138
31somite development (GO:0061053)2.94576172
32kynurenine metabolic process (GO:0070189)2.92454643
33negative regulation of mast cell activation (GO:0033004)2.91648594
34oxygen transport (GO:0015671)2.90699424
35indolalkylamine metabolic process (GO:0006586)2.89931489
36DNA methylation involved in gamete generation (GO:0043046)2.89651923
37regulation of microtubule-based movement (GO:0060632)2.89380662
38negative regulation of protein localization to cell surface (GO:2000009)2.89305719
39platelet dense granule organization (GO:0060155)2.89211820
40negative regulation of heart rate (GO:0010459)2.87250625
41mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.87010714
42calcium ion import (GO:0070509)2.85306331
43negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.85013462
44water-soluble vitamin biosynthetic process (GO:0042364)2.84678338
45epithelial cilium movement (GO:0003351)2.80134927
46regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.77834783
47positive regulation of cAMP-mediated signaling (GO:0043950)2.77402848
48parturition (GO:0007567)2.75174331
49mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.72625776
50mitochondrial respiratory chain complex I assembly (GO:0032981)2.72625776
51NADH dehydrogenase complex assembly (GO:0010257)2.72625776
52cellular biogenic amine catabolic process (GO:0042402)2.70590021
53amine catabolic process (GO:0009310)2.70590021
54GPI anchor metabolic process (GO:0006505)2.69850758
55transmission of nerve impulse (GO:0019226)2.69687955
56cellular biogenic amine biosynthetic process (GO:0042401)2.66712569
57nucleobase catabolic process (GO:0046113)2.65961190
58intraciliary transport (GO:0042073)2.64992105
59response to pheromone (GO:0019236)2.64838960
60negative regulation of systemic arterial blood pressure (GO:0003085)2.58846034
61lipoxygenase pathway (GO:0019372)2.58799382
62snRNA transcription (GO:0009301)2.57905029
63tachykinin receptor signaling pathway (GO:0007217)2.56014999
64triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.55582487
65ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.55228707
66multicellular organism reproduction (GO:0032504)2.54148869
67axoneme assembly (GO:0035082)2.53751438
68calcium ion-dependent exocytosis (GO:0017156)2.52868918
69gamma-aminobutyric acid transport (GO:0015812)2.51714237
70regulation of action potential (GO:0098900)2.48046559
71amine biosynthetic process (GO:0009309)2.47324926
72cilium organization (GO:0044782)2.47272569
73phosphatidylserine acyl-chain remodeling (GO:0036150)2.45831358
74protein complex biogenesis (GO:0070271)2.45670784
75cilium assembly (GO:0042384)2.45013753
76male meiosis I (GO:0007141)2.44280235
77tryptophan catabolic process (GO:0006569)2.42431894
78indole-containing compound catabolic process (GO:0042436)2.42431894
79indolalkylamine catabolic process (GO:0046218)2.42431894
80sulfation (GO:0051923)2.41692053
81substrate-independent telencephalic tangential migration (GO:0021826)2.41029876
82substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.41029876
83C-terminal protein lipidation (GO:0006501)2.40227450
84cilium movement (GO:0003341)2.39961468
85head development (GO:0060322)2.38649526
86phosphatidylinositol acyl-chain remodeling (GO:0036149)2.38022377
87piRNA metabolic process (GO:0034587)2.36503814
88sleep (GO:0030431)2.35247149
89chaperone-mediated protein transport (GO:0072321)2.35149606
90adaptation of signaling pathway (GO:0023058)2.31400257
91glycosphingolipid biosynthetic process (GO:0006688)2.30148358
92endoderm formation (GO:0001706)2.29701513
93primary amino compound metabolic process (GO:1901160)2.26048415
94regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.25943879
95establishment of protein localization to Golgi (GO:0072600)2.25704685
96female mating behavior (GO:0060180)2.25438116
97C-terminal protein amino acid modification (GO:0018410)2.25378843
98gas transport (GO:0015669)2.24842652
99cellular ketone body metabolic process (GO:0046950)2.22705788
100mitochondrial calcium ion homeostasis (GO:0051560)2.21732023

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.66879778
2ZNF274_21170338_ChIP-Seq_K562_Hela2.89496423
3VDR_22108803_ChIP-Seq_LS180_Human2.75928159
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.74749607
5GBX2_23144817_ChIP-Seq_PC3_Human2.58213810
6IRF1_19129219_ChIP-ChIP_H3396_Human2.55986518
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.25615518
8IGF1R_20145208_ChIP-Seq_DFB_Human1.95720956
9FLI1_27457419_Chip-Seq_LIVER_Mouse1.93418638
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.93120531
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.88850282
12BMI1_23680149_ChIP-Seq_NPCS_Mouse1.85659948
13ZFP57_27257070_Chip-Seq_ESCs_Mouse1.84865077
14JARID2_20064375_ChIP-Seq_MESCs_Mouse1.82592967
15CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82541631
16CBX2_27304074_Chip-Seq_ESCs_Mouse1.75059659
17EED_16625203_ChIP-ChIP_MESCs_Mouse1.74108736
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.73521426
19RNF2_27304074_Chip-Seq_NSC_Mouse1.72384739
20REST_21632747_ChIP-Seq_MESCs_Mouse1.71957212
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71582194
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.69028384
23EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67887294
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58895019
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.58154078
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.56216935
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.48886664
28BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.48334780
29ER_23166858_ChIP-Seq_MCF-7_Human1.48148892
30MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46385366
31EWS_26573619_Chip-Seq_HEK293_Human1.46242380
32P300_19829295_ChIP-Seq_ESCs_Human1.45534169
33AR_21572438_ChIP-Seq_LNCaP_Human1.44681452
34TAF15_26573619_Chip-Seq_HEK293_Human1.44343377
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.43340633
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.40479262
37JARID2_20075857_ChIP-Seq_MESCs_Mouse1.39375309
38GATA3_21878914_ChIP-Seq_MCF-7_Human1.36548466
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35339615
40SMAD4_21799915_ChIP-Seq_A2780_Human1.34684210
41REST_18959480_ChIP-ChIP_MESCs_Mouse1.33460312
42AR_25329375_ChIP-Seq_VCAP_Human1.33448857
43TCF4_23295773_ChIP-Seq_U87_Human1.32165968
44SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.31763932
45TP53_22573176_ChIP-Seq_HFKS_Human1.31699639
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30689829
47UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30173050
48FUS_26573619_Chip-Seq_HEK293_Human1.29550589
49DROSHA_22980978_ChIP-Seq_HELA_Human1.28422992
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28072719
51LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.27847849
52STAT3_23295773_ChIP-Seq_U87_Human1.26845537
53AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24459191
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24445157
55NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24198244
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23329007
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21505855
58P53_22127205_ChIP-Seq_FIBROBLAST_Human1.20137453
59SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.19746458
60TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17010809
61SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.16600004
62RNF2_18974828_ChIP-Seq_MESCs_Mouse1.15924879
63EZH2_18974828_ChIP-Seq_MESCs_Mouse1.15924879
64SOX2_19829295_ChIP-Seq_ESCs_Human1.15628175
65NANOG_19829295_ChIP-Seq_ESCs_Human1.15628175
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12999049
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10529135
68BCAT_22108803_ChIP-Seq_LS180_Human1.10526888
69ERA_21632823_ChIP-Seq_H3396_Human1.08850418
70SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.08792404
71CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.08610921
72CBP_20019798_ChIP-Seq_JUKART_Human1.08266671
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08266671
74EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.06769601
75RNF2_27304074_Chip-Seq_ESCs_Mouse1.06068210
76TCF4_22108803_ChIP-Seq_LS180_Human1.05982203
77TAL1_26923725_Chip-Seq_HPCs_Mouse1.05673495
78HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.05257054
79POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04969319
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04969319
81ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03894663
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03172566
83SMAD4_21741376_ChIP-Seq_EPCs_Human1.03109079
84RUNX2_22187159_ChIP-Seq_PCA_Human1.02577230
85AR_20517297_ChIP-Seq_VCAP_Human1.02180707
86OCT1_27270436_Chip-Seq_PROSTATE_Human1.01674053
87FLI1_21867929_ChIP-Seq_TH2_Mouse1.01212529
88NCOR_22424771_ChIP-Seq_293T_Human1.00038917
89NANOG_20526341_ChIP-Seq_ESCs_Human0.99928585
90SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99665226
91TDRD3_21172665_ChIP-Seq_MCF-7_Human0.99145974
92SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96906811
93MYC_19829295_ChIP-Seq_ESCs_Human0.94222854
94HTT_18923047_ChIP-ChIP_STHdh_Human0.94137494
95FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93347976
96FOXA1_25329375_ChIP-Seq_VCAP_Human0.93347976
97KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92824488
98MTF2_20144788_ChIP-Seq_MESCs_Mouse0.92800423
99OCT4_20526341_ChIP-Seq_ESCs_Human0.92227578
100PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91922539

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue3.23061261
2MP0006276_abnormal_autonomic_nervous2.56821531
3MP0006292_abnormal_olfactory_placode2.56811247
4MP0004885_abnormal_endolymph2.56223983
5MP0002736_abnormal_nociception_after2.52411017
6MP0003879_abnormal_hair_cell2.41235274
7MP0001968_abnormal_touch/_nociception2.23317129
8MP0003011_delayed_dark_adaptation2.21652170
9MP0004145_abnormal_muscle_electrophysio2.21061687
10MP0005646_abnormal_pituitary_gland2.20124974
11MP0003880_abnormal_central_pattern2.17188955
12MP0004043_abnormal_pH_regulation2.05015226
13MP0008872_abnormal_physiological_respon1.90595600
14MP0005377_hearing/vestibular/ear_phenot1.89552666
15MP0003878_abnormal_ear_physiology1.89552666
16MP0005551_abnormal_eye_electrophysiolog1.88936030
17MP0004147_increased_porphyrin_level1.87849476
18MP0009046_muscle_twitch1.86844695
19MP0000372_irregular_coat_pigmentation1.82542357
20MP0002653_abnormal_ependyma_morphology1.78082748
21MP0003195_calcinosis1.75864667
22MP0002102_abnormal_ear_morphology1.73384810
23MP0002735_abnormal_chemical_nociception1.73382640
24MP0004142_abnormal_muscle_tone1.69883005
25MP0005083_abnormal_biliary_tract1.68060716
26MP0002272_abnormal_nervous_system1.67808855
27MP0009379_abnormal_foot_pigmentation1.66941590
28MP0001188_hyperpigmentation1.60616583
29MP0000631_abnormal_neuroendocrine_gland1.55742571
30MP0002234_abnormal_pharynx_morphology1.54831447
31MP0001486_abnormal_startle_reflex1.53884571
32MP0005645_abnormal_hypothalamus_physiol1.53724301
33MP0002557_abnormal_social/conspecific_i1.53313167
34MP0003122_maternal_imprinting1.49270465
35MP0004742_abnormal_vestibular_system1.48964602
36MP0008789_abnormal_olfactory_epithelium1.48826307
37MP0002733_abnormal_thermal_nociception1.48550083
38MP0002876_abnormal_thyroid_physiology1.48022149
39MP0001919_abnormal_reproductive_system1.46920459
40MP0001485_abnormal_pinna_reflex1.46286592
41MP0008877_abnormal_DNA_methylation1.45947417
42MP0005423_abnormal_somatic_nervous1.45130443
43MP0001440_abnormal_grooming_behavior1.41224488
44MP0001970_abnormal_pain_threshold1.35556698
45MP0002822_catalepsy1.35127742
46MP0000230_abnormal_systemic_arterial1.32504298
47MP0009745_abnormal_behavioral_response1.31794650
48MP0005167_abnormal_blood-brain_barrier1.31704569
49MP0006072_abnormal_retinal_apoptosis1.30956523
50MP0004133_heterotaxia1.28804077
51MP0003635_abnormal_synaptic_transmissio1.27331384
52MP0005410_abnormal_fertilization1.25616658
53MP0002138_abnormal_hepatobiliary_system1.25466024
54MP0002572_abnormal_emotion/affect_behav1.24719966
55MP0001879_abnormal_lymphatic_vessel1.23936874
56MP0005499_abnormal_olfactory_system1.23763035
57MP0005394_taste/olfaction_phenotype1.23763035
58MP0005670_abnormal_white_adipose1.23493726
59MP0000026_abnormal_inner_ear1.22881813
60MP0005253_abnormal_eye_physiology1.21487625
61MP0002163_abnormal_gland_morphology1.17051947
62MP0002909_abnormal_adrenal_gland1.16481742
63MP0003787_abnormal_imprinting1.15107717
64MP0001963_abnormal_hearing_physiology1.14597537
65MP0005084_abnormal_gallbladder_morpholo1.14254122
66MP0003119_abnormal_digestive_system1.14131985
67MP0001501_abnormal_sleep_pattern1.13716980
68MP0002638_abnormal_pupillary_reflex1.12172033
69MP0002063_abnormal_learning/memory/cond1.11673853
70MP0005389_reproductive_system_phenotype1.11107925
71MP0004130_abnormal_muscle_cell1.09904858
72MP0002938_white_spotting1.08693475
73MP0005174_abnormal_tail_pigmentation1.08517568
74MP0002095_abnormal_skin_pigmentation1.07465094
75MP0000049_abnormal_middle_ear1.06564973
76MP0000778_abnormal_nervous_system1.06464965
77MP0004859_abnormal_synaptic_plasticity1.06076039
78MP0002160_abnormal_reproductive_system1.05796183
79MP0005464_abnormal_platelet_physiology1.01326398
80MP0002837_dystrophic_cardiac_calcinosis0.99850725
81MP0002752_abnormal_somatic_nervous0.99137461
82MP0002064_seizures0.98424512
83MP0002067_abnormal_sensory_capabilities0.98016752
84MP0002184_abnormal_innervation0.96796969
85MP0008775_abnormal_heart_ventricle0.96289707
86MP0002928_abnormal_bile_duct0.94891779
87MP0001986_abnormal_taste_sensitivity0.89897610
88MP0001905_abnormal_dopamine_level0.89133715
89MP0005360_urolithiasis0.87910034
90MP0002734_abnormal_mechanical_nocicepti0.86726402
91MP0010329_abnormal_lipoprotein_level0.84964112
92MP0004085_abnormal_heartbeat0.81445467
93MP0003938_abnormal_ear_development0.79899431
94MP0004036_abnormal_muscle_relaxation0.78669247
95MP0003283_abnormal_digestive_organ0.77408924
96MP0002229_neurodegeneration0.76381575
97MP0001293_anophthalmia0.76256624
98MP0005195_abnormal_posterior_eye0.75995879
99MP0000015_abnormal_ear_pigmentation0.75959428
100MP0000955_abnormal_spinal_cord0.75804571

Predicted human phenotypes

RankGene SetZ-score
1Decreased central vision (HP:0007663)3.87991703
2Abnormality of midbrain morphology (HP:0002418)3.45306706
3Molar tooth sign on MRI (HP:0002419)3.45306706
4Pancreatic cysts (HP:0001737)3.43588430
5Type II lissencephaly (HP:0007260)3.26715524
6Pancreatic fibrosis (HP:0100732)3.25610147
7Nephronophthisis (HP:0000090)3.23603720
8Medial flaring of the eyebrow (HP:0010747)3.00053670
9Gait imbalance (HP:0002141)2.86737898
10Congenital stationary night blindness (HP:0007642)2.81540089
11Nephrogenic diabetes insipidus (HP:0009806)2.80321377
12True hermaphroditism (HP:0010459)2.79229391
13Abnormality of the renal medulla (HP:0100957)2.77551708
14Lipid accumulation in hepatocytes (HP:0006561)2.76759469
15Congenital primary aphakia (HP:0007707)2.73759923
16Acute encephalopathy (HP:0006846)2.73543016
17Thyroid-stimulating hormone excess (HP:0002925)2.69494590
18Abnormality of the renal cortex (HP:0011035)2.59879409
19Acute necrotizing encephalopathy (HP:0006965)2.58870901
20Genetic anticipation (HP:0003743)2.57863174
21Poor coordination (HP:0002370)2.55860577
22Abnormal hemoglobin (HP:0011902)2.48861295
23Hyperglycinemia (HP:0002154)2.47422311
24Abnormality of the heme biosynthetic pathway (HP:0010472)2.45391554
25Mitochondrial inheritance (HP:0001427)2.38523118
26Lissencephaly (HP:0001339)2.36539397
27Abnormality of macular pigmentation (HP:0008002)2.36319451
28Polydipsia (HP:0001959)2.33547775
29Abnormal drinking behavior (HP:0030082)2.33547775
30Prolonged bleeding time (HP:0003010)2.31321280
31Progressive cerebellar ataxia (HP:0002073)2.28420256
32Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.25811771
33Abnormal mitochondria in muscle tissue (HP:0008316)2.25028354
34Acanthocytosis (HP:0001927)2.23841946
35Abnormal respiratory motile cilium morphology (HP:0005938)2.22098484
36Abnormal respiratory epithelium morphology (HP:0012253)2.22098484
37Arthropathy (HP:0003040)2.21913152
38Cystic liver disease (HP:0006706)2.21130813
39Petechiae (HP:0000967)2.21095075
40Hyperlipoproteinemia (HP:0010980)2.19818548
41Abnormality of the phalanges of the 5th finger (HP:0004213)2.18788050
42Cerebellar dysplasia (HP:0007033)2.18604913
43Febrile seizures (HP:0002373)2.17486121
44Abnormal rod and cone electroretinograms (HP:0008323)2.15890063
45Chronic hepatic failure (HP:0100626)2.15157899
46Polyphagia (HP:0002591)2.15080133
47Failure to thrive in infancy (HP:0001531)2.14415302
48Aplasia/Hypoplasia of the tibia (HP:0005772)2.13964344
49Absent rod-and cone-mediated responses on ERG (HP:0007688)2.12514313
50Anencephaly (HP:0002323)2.11903113
51Attenuation of retinal blood vessels (HP:0007843)2.11452302
52Abolished electroretinogram (ERG) (HP:0000550)2.10149622
53Vaginal atresia (HP:0000148)2.08131876
54Absent/shortened dynein arms (HP:0200106)2.06992839
55Dynein arm defect of respiratory motile cilia (HP:0012255)2.06992839
56Genital tract atresia (HP:0001827)2.06967114
57Pendular nystagmus (HP:0012043)2.06565943
58Progressive macrocephaly (HP:0004481)2.06096512
59Increased CSF lactate (HP:0002490)2.04352462
60Bony spicule pigmentary retinopathy (HP:0007737)2.04273304
61Abnormality of alanine metabolism (HP:0010916)2.03998164
62Hyperalaninemia (HP:0003348)2.03998164
63Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.03998164
64Agitation (HP:0000713)2.01162192
65Myokymia (HP:0002411)2.00508085
66Postaxial foot polydactyly (HP:0001830)2.00138865
67Congenital sensorineural hearing impairment (HP:0008527)1.99904656
68Sclerocornea (HP:0000647)1.99420076
69Pachygyria (HP:0001302)1.98692182
70Absent thumb (HP:0009777)1.98457485
71Tubulointerstitial nephritis (HP:0001970)1.97357626
72Renal cortical cysts (HP:0000803)1.96179246
73Enlarged kidneys (HP:0000105)1.95282149
74Poikilocytosis (HP:0004447)1.94476487
75Short tibia (HP:0005736)1.93703707
76Increased muscle lipid content (HP:0009058)1.90366962
77Abnormality of DNA repair (HP:0003254)1.87760467
78Decreased circulating renin level (HP:0003351)1.87673242
79Abnormality of the nasal septum (HP:0000419)1.87416996
80Pallor (HP:0000980)1.87038500
81Bulbous nose (HP:0000414)1.85248527
82Congenital hepatic fibrosis (HP:0002612)1.85123749
83Methylmalonic acidemia (HP:0002912)1.83178512
84Keratoconus (HP:0000563)1.81708342
85Increased corneal curvature (HP:0100692)1.81708342
86Dyskinesia (HP:0100660)1.78736606
87Epileptic encephalopathy (HP:0200134)1.78615883
88Severe visual impairment (HP:0001141)1.76881793
89Male pseudohermaphroditism (HP:0000037)1.76688045
90Tubular atrophy (HP:0000092)1.76616959
91Occipital encephalocele (HP:0002085)1.75927119
92Specific learning disability (HP:0001328)1.75536395
93Methylmalonic aciduria (HP:0012120)1.75400357
94Postaxial hand polydactyly (HP:0001162)1.74803063
95Abnormal ciliary motility (HP:0012262)1.74678378
96Menorrhagia (HP:0000132)1.74187555
97Renal Fanconi syndrome (HP:0001994)1.73932908
98Hepatocellular necrosis (HP:0001404)1.73596395
99Abnormality of dental color (HP:0011073)1.72732652
100Aplasia/Hypoplasia of the spleen (HP:0010451)1.72074639

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.62650812
2AKT33.22841351
3MAP4K23.22456823
4WNK43.03590528
5ADRBK22.95773609
6INSRR2.92457635
7FRK2.91451538
8TLK12.58981601
9GRK12.08133461
10MAP3K42.02777613
11STK391.91743959
12ZAK1.90406950
13CAMKK21.84134029
14PINK11.79103858
15MAPK131.72672898
16CASK1.65711636
17DYRK21.59066213
18WNK31.46002107
19MAP2K21.45699403
20BMPR1B1.45663754
21SIK21.43099706
22MAP2K71.38073372
23DAPK21.30443316
24ADRBK11.22781592
25TXK1.21767393
26NUAK11.16291486
27PAK31.12816175
28SGK21.10323448
29CAMK11.04615342
30TNK21.03415490
31MST41.02049682
32CSNK1A1L1.00656060
33CSNK1G21.00609318
34SGK2230.99264616
35SGK4940.99264616
36CDK80.98505018
37TNIK0.96530596
38NTRK20.96316075
39MARK10.89992058
40DYRK30.89568920
41CSNK1G30.89322393
42BCKDK0.88724122
43STK110.84329312
44NTRK30.83017173
45TIE10.81718085
46PRKCG0.81682480
47ERN10.81500386
48CAMK40.80977369
49CAMKK10.76987213
50MAP3K90.76360232
51OXSR10.75871793
52CSNK1G10.75156095
53OBSCN0.75101553
54EPHA30.71704130
55PHKG20.70743525
56PHKG10.70743525
57PRKACA0.70692501
58IKBKB0.70369654
59PRKCQ0.70035806
60PIK3CG0.68380947
61PKN10.68194325
62ERBB20.65757418
63MYLK0.65111301
64BCR0.65070264
65PIK3CA0.65008873
66TEC0.62009032
67EPHA40.61810184
68ACVR1B0.61786938
69GRK50.61033094
70MAP2K10.60433867
71PLK20.60253177
72CAMK2A0.59006641
73RPS6KA50.57937829
74BTK0.56582115
75DYRK1A0.56427092
76PRKCZ0.56157788
77WNK10.55531611
78PTK2B0.54795706
79MATK0.52936186
80PRKACG0.52140721
81AURKA0.51933316
82CAMK1D0.49409848
83PRKCA0.49249708
84PRKCE0.48762325
85CAMK1G0.48749499
86PDK20.48024584
87SYK0.47698673
88MARK20.46515524
89GRK60.45617733
90PLK40.45595179
91PRKG10.45101030
92MAP2K40.45069860
93STK38L0.44838685
94BRAF0.43283981
95DAPK30.42835172
96SGK30.42037003
97CSNK1A10.41411942
98PRKD30.39964986
99DYRK1B0.38122927
100BMX0.37513457

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.20562602
2Nicotine addiction_Homo sapiens_hsa050332.54352498
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.51683446
4Linoleic acid metabolism_Homo sapiens_hsa005912.46146826
5Oxidative phosphorylation_Homo sapiens_hsa001902.40525067
6Phototransduction_Homo sapiens_hsa047442.21465739
7Olfactory transduction_Homo sapiens_hsa047402.13729861
8Morphine addiction_Homo sapiens_hsa050321.99599549
9Sulfur relay system_Homo sapiens_hsa041221.94496784
10Parkinsons disease_Homo sapiens_hsa050121.90031282
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.81080694
12Primary bile acid biosynthesis_Homo sapiens_hsa001201.80612567
13Maturity onset diabetes of the young_Homo sapiens_hsa049501.79419409
14Cardiac muscle contraction_Homo sapiens_hsa042601.71167256
15Ribosome_Homo sapiens_hsa030101.69173556
16Serotonergic synapse_Homo sapiens_hsa047261.68659341
17Arachidonic acid metabolism_Homo sapiens_hsa005901.68615301
18GABAergic synapse_Homo sapiens_hsa047271.67946566
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.64107372
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.57057579
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.46297396
22Huntingtons disease_Homo sapiens_hsa050161.45489975
23Nitrogen metabolism_Homo sapiens_hsa009101.42643094
24Alzheimers disease_Homo sapiens_hsa050101.40898970
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.39884544
26Taste transduction_Homo sapiens_hsa047421.39405126
27Circadian entrainment_Homo sapiens_hsa047131.38938850
28Chemical carcinogenesis_Homo sapiens_hsa052041.38187562
29Sulfur metabolism_Homo sapiens_hsa009201.37793979
30Basal transcription factors_Homo sapiens_hsa030221.36908802
31Butanoate metabolism_Homo sapiens_hsa006501.34057419
32Steroid biosynthesis_Homo sapiens_hsa001001.32588972
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.32145417
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.30850507
35Insulin secretion_Homo sapiens_hsa049111.29105606
36Retinol metabolism_Homo sapiens_hsa008301.27692476
37Fat digestion and absorption_Homo sapiens_hsa049751.24465626
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24032328
39Collecting duct acid secretion_Homo sapiens_hsa049661.23269051
40Glutamatergic synapse_Homo sapiens_hsa047241.20883072
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.19560457
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.15808296
43Ether lipid metabolism_Homo sapiens_hsa005651.15456978
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.11240911
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.09808937
46Alcoholism_Homo sapiens_hsa050341.09512363
47beta-Alanine metabolism_Homo sapiens_hsa004101.03616948
48Tryptophan metabolism_Homo sapiens_hsa003801.01401155
49Caffeine metabolism_Homo sapiens_hsa002321.00570596
50Protein export_Homo sapiens_hsa030600.99174661
51Peroxisome_Homo sapiens_hsa041460.96978444
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.95993770
53Regulation of autophagy_Homo sapiens_hsa041400.92586232
54RNA polymerase_Homo sapiens_hsa030200.90146611
55Ovarian steroidogenesis_Homo sapiens_hsa049130.89653741
56Salivary secretion_Homo sapiens_hsa049700.89593520
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86867796
58Propanoate metabolism_Homo sapiens_hsa006400.84924651
59Cholinergic synapse_Homo sapiens_hsa047250.84237152
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.83763332
61Calcium signaling pathway_Homo sapiens_hsa040200.83446201
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82967614
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82577914
64Arginine and proline metabolism_Homo sapiens_hsa003300.82573815
65Dopaminergic synapse_Homo sapiens_hsa047280.82276085
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80159803
67Fatty acid biosynthesis_Homo sapiens_hsa000610.79226402
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74987882
69Systemic lupus erythematosus_Homo sapiens_hsa053220.69146476
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67088206
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66165606
72Synaptic vesicle cycle_Homo sapiens_hsa047210.64196428
73Fanconi anemia pathway_Homo sapiens_hsa034600.63770900
74ABC transporters_Homo sapiens_hsa020100.63184232
75Selenocompound metabolism_Homo sapiens_hsa004500.60861688
76Phenylalanine metabolism_Homo sapiens_hsa003600.60612060
77Pancreatic secretion_Homo sapiens_hsa049720.57954232
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57744733
79Gastric acid secretion_Homo sapiens_hsa049710.57404254
80Metabolic pathways_Homo sapiens_hsa011000.57276665
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56827916
82Glycerolipid metabolism_Homo sapiens_hsa005610.56651868
83Bile secretion_Homo sapiens_hsa049760.54994834
84Amphetamine addiction_Homo sapiens_hsa050310.54864572
85Long-term depression_Homo sapiens_hsa047300.54448951
86cAMP signaling pathway_Homo sapiens_hsa040240.54401493
87Cocaine addiction_Homo sapiens_hsa050300.53051577
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51383458
89Oxytocin signaling pathway_Homo sapiens_hsa049210.51037130
90Tyrosine metabolism_Homo sapiens_hsa003500.48418133
91Starch and sucrose metabolism_Homo sapiens_hsa005000.47636796
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.47075136
93Homologous recombination_Homo sapiens_hsa034400.45495357
94Renin secretion_Homo sapiens_hsa049240.43901313
95Platelet activation_Homo sapiens_hsa046110.43213887
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.42267006
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40021803
98Hedgehog signaling pathway_Homo sapiens_hsa043400.39804445
99Ras signaling pathway_Homo sapiens_hsa040140.38891855
100One carbon pool by folate_Homo sapiens_hsa006700.38865852

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