MTRNR2L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.30883225
2establishment of protein localization to Golgi (GO:0072600)4.26413009
3synaptic vesicle docking involved in exocytosis (GO:0016081)4.02948639
4retrograde transport, vesicle recycling within Golgi (GO:0000301)3.78398129
5protein targeting to Golgi (GO:0000042)3.72654338
6nuclear pore organization (GO:0006999)3.66305162
7regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.55912237
8interkinetic nuclear migration (GO:0022027)3.39586913
9positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.23006975
10pore complex assembly (GO:0046931)3.20037878
11membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.09543754
12regulation of short-term neuronal synaptic plasticity (GO:0048172)3.09314377
13negative regulation of vascular permeability (GO:0043116)3.05578583
14cerebellar Purkinje cell differentiation (GO:0021702)3.04142269
15negative regulation of neurotransmitter secretion (GO:0046929)3.04061804
16negative regulation of protein localization to cell surface (GO:2000009)3.00168294
17regulation of synaptic vesicle exocytosis (GO:2000300)2.93096564
18regulation of cell communication by electrical coupling (GO:0010649)2.92985480
19cytoplasmic mRNA processing body assembly (GO:0033962)2.91116427
20negative regulation of neurotransmitter transport (GO:0051589)2.91114536
21glutamate secretion (GO:0014047)2.84533501
22negative regulation of cytosolic calcium ion concentration (GO:0051481)2.82364575
23regulation of sarcomere organization (GO:0060297)2.82019669
24phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.80084275
25positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.79721230
26L-amino acid import (GO:0043092)2.77534675
27regulation of cAMP-dependent protein kinase activity (GO:2000479)2.76510551
28nucleus localization (GO:0051647)2.76375766
29protein K48-linked deubiquitination (GO:0071108)2.73976176
30microtubule depolymerization (GO:0007019)2.67249800
31Golgi to endosome transport (GO:0006895)2.67103569
32microtubule polymerization or depolymerization (GO:0031109)2.66473684
33regulation of pigment cell differentiation (GO:0050932)2.63065995
34vesicle transport along microtubule (GO:0047496)2.62807412
35regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.61975415
36microtubule anchoring (GO:0034453)2.61223429
37regulation of synaptic vesicle transport (GO:1902803)2.60174847
38gamma-aminobutyric acid signaling pathway (GO:0007214)2.58252789
39protein localization to Golgi apparatus (GO:0034067)2.55960081
40regulation of clathrin-mediated endocytosis (GO:2000369)2.55495811
41positive regulation of cardiac muscle hypertrophy (GO:0010613)2.53975257
42positive regulation of muscle hypertrophy (GO:0014742)2.53975257
43synaptic vesicle maturation (GO:0016188)2.50015818
44regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.49810893
45artery development (GO:0060840)2.48775187
46bundle of His cell to Purkinje myocyte communication (GO:0086069)2.48094092
47cell communication involved in cardiac conduction (GO:0086065)2.46966274
48C4-dicarboxylate transport (GO:0015740)2.46746554
49synaptic vesicle exocytosis (GO:0016079)2.45976243
50protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.44064399
51ventricular cardiac muscle cell action potential (GO:0086005)2.42889891
52multicellular organismal movement (GO:0050879)2.42769829
53musculoskeletal movement (GO:0050881)2.42769829
54regulation of female receptivity (GO:0045924)2.41181274
55regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.41121372
56organelle transport along microtubule (GO:0072384)2.38376651
57cyclic nucleotide catabolic process (GO:0009214)2.38117839
58neuronal action potential propagation (GO:0019227)2.37978915
59regulation of voltage-gated calcium channel activity (GO:1901385)2.37950500
60cardiac muscle cell action potential (GO:0086001)2.37525883
61long-chain fatty acid biosynthetic process (GO:0042759)2.37137987
62detection of calcium ion (GO:0005513)2.37077738
63membrane depolarization during action potential (GO:0086010)2.36447499
64embryonic retina morphogenesis in camera-type eye (GO:0060059)2.34795861
65cardiac muscle hypertrophy (GO:0003300)2.33564152
66negative regulation of translation, ncRNA-mediated (GO:0040033)2.31132331
67regulation of translation, ncRNA-mediated (GO:0045974)2.31132331
68negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.31132331
69cytoskeletal anchoring at plasma membrane (GO:0007016)2.29929544
70genitalia morphogenesis (GO:0035112)2.29567269
71clathrin coat assembly (GO:0048268)2.29431525
72regulation of establishment of cell polarity (GO:2000114)2.29400220
73intra-Golgi vesicle-mediated transport (GO:0006891)2.27476887
74calcium ion-dependent exocytosis (GO:0017156)2.27238226
75microtubule nucleation (GO:0007020)2.26958132
76carnitine shuttle (GO:0006853)2.26646893
77Golgi to plasma membrane protein transport (GO:0043001)2.26261590
78centrosome duplication (GO:0051298)2.25615854
79early endosome to late endosome transport (GO:0045022)2.25568115
80vesicle docking (GO:0048278)2.25522055
81gamma-aminobutyric acid transport (GO:0015812)2.25231303
82cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.24960115
83negative regulation of blood circulation (GO:1903523)2.24749655
84positive regulation of glycolytic process (GO:0045821)2.24504527
85cAMP catabolic process (GO:0006198)2.23144437
86regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.22573970
87striated muscle hypertrophy (GO:0014897)2.22364124
88regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.22135209
89serotonin metabolic process (GO:0042428)2.21935054
90amino acid import (GO:0043090)2.21654768
91Golgi to plasma membrane transport (GO:0006893)2.21313518
92peripheral nervous system axon ensheathment (GO:0032292)2.20803936
93myelination in peripheral nervous system (GO:0022011)2.20803936
94atrial cardiac muscle cell action potential (GO:0086014)2.20307889
95cardiac muscle cell action potential involved in contraction (GO:0086002)2.19620561
96pre-miRNA processing (GO:0031054)2.19102356
97fibroblast migration (GO:0010761)2.18592359
98cGMP-mediated signaling (GO:0019934)2.15681531
99neuron-neuron synaptic transmission (GO:0007270)2.15327788
100synaptic vesicle endocytosis (GO:0048488)2.14061220

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.38130127
2EZH2_22144423_ChIP-Seq_EOC_Human3.45272617
3GBX2_23144817_ChIP-Seq_PC3_Human3.21132829
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.71775867
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.70659188
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.67729181
7SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.51142657
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.50845367
9TAF15_26573619_Chip-Seq_HEK293_Human2.43138369
10IGF1R_20145208_ChIP-Seq_DFB_Human2.42622283
11AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.42234193
12SMAD4_21799915_ChIP-Seq_A2780_Human2.19642440
13AR_21572438_ChIP-Seq_LNCaP_Human2.14329390
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.13613212
15PIAS1_25552417_ChIP-Seq_VCAP_Human2.09980082
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.08584435
17STAT3_23295773_ChIP-Seq_U87_Human1.94839084
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.87710999
19ZNF217_24962896_ChIP-Seq_MCF-7_Human1.87597893
20P300_19829295_ChIP-Seq_ESCs_Human1.86688362
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85628421
22FUS_26573619_Chip-Seq_HEK293_Human1.81466589
23MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.74234849
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.70418089
25TCF4_23295773_ChIP-Seq_U87_Human1.69109835
26OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.68928017
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67804647
28TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.64591775
29SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64006386
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56955186
31PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.50485182
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49831344
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.48359782
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46889259
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46033912
36CTNNB1_20460455_ChIP-Seq_HCT116_Human1.46022598
37SMAD3_21741376_ChIP-Seq_EPCs_Human1.43434073
38NR3C1_21868756_ChIP-Seq_MCF10A_Human1.43102231
39TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.41800636
40ARNT_22903824_ChIP-Seq_MCF-7_Human1.41697407
41AR_25329375_ChIP-Seq_VCAP_Human1.40733377
42CBP_20019798_ChIP-Seq_JUKART_Human1.39419345
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39419345
44AHR_22903824_ChIP-Seq_MCF-7_Human1.37205148
45TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35805112
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34711492
47SOX2_21211035_ChIP-Seq_LN229_Gbm1.33310389
48FOXM1_26456572_ChIP-Seq_MCF-7_Human1.32853438
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.31690144
50NANOG_18555785_Chip-Seq_ESCs_Mouse1.28741692
51NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28230936
52POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28223382
53TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28223382
54VDR_22108803_ChIP-Seq_LS180_Human1.27010893
55EP300_21415370_ChIP-Seq_HL-1_Mouse1.23243752
56EWS_26573619_Chip-Seq_HEK293_Human1.21646920
57TP53_16413492_ChIP-PET_HCT116_Human1.21586978
58ER_23166858_ChIP-Seq_MCF-7_Human1.21517420
59E2F1_18555785_Chip-Seq_ESCs_Mouse1.20580639
60TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18823094
61NRF2_20460467_ChIP-Seq_MEFs_Mouse1.16877572
62NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.16877572
63TCF4_18268006_ChIP-ChIP_LS174T_Human1.16329677
64YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15713448
65AR_19668381_ChIP-Seq_PC3_Human1.14932430
66RUNX2_22187159_ChIP-Seq_PCA_Human1.14585289
67FLI1_21867929_ChIP-Seq_TH2_Mouse1.13256983
68ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.11206500
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.10063456
70TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.10050780
71CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09518463
72TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08982828
73TP53_18474530_ChIP-ChIP_U2OS_Human1.08321520
74RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07986736
75TCF4_22108803_ChIP-Seq_LS180_Human1.07791131
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06939418
77P53_22387025_ChIP-Seq_ESCs_Mouse1.06388222
78SOX9_26525672_Chip-Seq_HEART_Mouse1.05474073
79TAL1_26923725_Chip-Seq_HPCs_Mouse1.05155268
80SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04669804
81TBL1_22424771_ChIP-Seq_293T_Human1.04151252
82PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03882402
83RNF2_27304074_Chip-Seq_NSC_Mouse1.03489788
84BCAT_22108803_ChIP-Seq_LS180_Human1.03271355
85SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.01450561
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.00565479
87CDX2_22108803_ChIP-Seq_LS180_Human1.00154301
88KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99893303
89RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99647071
90KDM2B_26808549_Chip-Seq_REH_Human0.99618097
91LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99106517
92RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98848908
93SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.97171040
94CMYC_18555785_Chip-Seq_ESCs_Mouse0.94748100
95CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93699436
96ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93129666
97JUN_21703547_ChIP-Seq_K562_Human0.92777269
98DROSHA_22980978_ChIP-Seq_HELA_Human0.92490266
99ESR1_20079471_ChIP-ChIP_T-47D_Human0.92396816
100REST_21632747_ChIP-Seq_MESCs_Mouse0.91459105

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004270_analgesia3.00070065
2MP0000569_abnormal_digit_pigmentation2.82336545
3MP0004859_abnormal_synaptic_plasticity2.71304763
4MP0009046_muscle_twitch2.60699227
5MP0002009_preneoplasia2.58650600
6MP0008057_abnormal_DNA_replication2.50218926
7MP0003646_muscle_fatigue2.26361728
8MP0009780_abnormal_chondrocyte_physiolo2.22171604
9MP0010352_gastrointestinal_tract_polyps2.19037748
10MP0009697_abnormal_copulation2.12697397
11MP0004036_abnormal_muscle_relaxation2.09497186
12MP0003880_abnormal_central_pattern2.04174883
13MP0004084_abnormal_cardiac_muscle2.04156722
14MP0004130_abnormal_muscle_cell2.03380210
15MP0001486_abnormal_startle_reflex1.97518599
16MP0005670_abnormal_white_adipose1.88523901
17MP0003635_abnormal_synaptic_transmissio1.81477278
18MP0004215_abnormal_myocardial_fiber1.76524390
19MP0001984_abnormal_olfaction1.75407362
20MP0003879_abnormal_hair_cell1.73066051
21MP0006276_abnormal_autonomic_nervous1.71186067
22MP0003941_abnormal_skin_development1.70569056
23MP0002064_seizures1.65829169
24MP0002272_abnormal_nervous_system1.62773020
25MP0003890_abnormal_embryonic-extraembry1.57760807
26MP0002063_abnormal_learning/memory/cond1.56348146
27MP0008004_abnormal_stomach_pH1.55831966
28MP0005409_darkened_coat_color1.54414983
29MP0005646_abnormal_pituitary_gland1.53583223
30MP0001501_abnormal_sleep_pattern1.48820230
31MP0004145_abnormal_muscle_electrophysio1.48641152
32MP0005187_abnormal_penis_morphology1.46727474
33MP0009745_abnormal_behavioral_response1.41815850
34MP0004233_abnormal_muscle_weight1.41153158
35MP0001879_abnormal_lymphatic_vessel1.40761804
36MP0005167_abnormal_blood-brain_barrier1.38079013
37MP0004484_altered_response_of1.36726630
38MP0002572_abnormal_emotion/affect_behav1.34743079
39MP0004085_abnormal_heartbeat1.33205815
40MP0004924_abnormal_behavior1.30660159
41MP0005386_behavior/neurological_phenoty1.30660159
42MP0005423_abnormal_somatic_nervous1.30110848
43MP0001661_extended_life_span1.28599251
44MP0004134_abnormal_chest_morphology1.26004530
45MP0002734_abnormal_mechanical_nocicepti1.22301560
46MP0001299_abnormal_eye_distance/1.21735498
47MP0002638_abnormal_pupillary_reflex1.20761612
48MP0002557_abnormal_social/conspecific_i1.17666291
49MP0001188_hyperpigmentation1.17326690
50MP0004147_increased_porphyrin_level1.15551171
51MP0005410_abnormal_fertilization1.13637663
52MP0003633_abnormal_nervous_system1.10427352
53MP0002067_abnormal_sensory_capabilities1.09041126
54MP0002822_catalepsy1.08267635
55MP0008569_lethality_at_weaning1.06248862
56MP0000383_abnormal_hair_follicle1.05780560
57MP0006138_congestive_heart_failure1.05764638
58MP0005645_abnormal_hypothalamus_physiol1.05423951
59MP0002735_abnormal_chemical_nociception1.04171761
60MP0010386_abnormal_urinary_bladder1.01652936
61MP0005620_abnormal_muscle_contractility0.99971833
62MP0005551_abnormal_eye_electrophysiolog0.99896655
63MP0003787_abnormal_imprinting0.98277125
64MP0005666_abnormal_adipose_tissue0.98066136
65MP0003868_abnormal_feces_composition0.96800881
66MP0003137_abnormal_impulse_conducting0.95106637
67MP0000465_gastrointestinal_hemorrhage0.93990274
68MP0004811_abnormal_neuron_physiology0.91136146
69MP0005253_abnormal_eye_physiology0.91038878
70MP0005083_abnormal_biliary_tract0.90611793
71MP0000751_myopathy0.90011284
72MP0000778_abnormal_nervous_system0.88343546
73MP0003631_nervous_system_phenotype0.87745710
74MP0010678_abnormal_skin_adnexa0.87659096
75MP0000230_abnormal_systemic_arterial0.85936907
76MP0001968_abnormal_touch/_nociception0.85812904
77MP0000013_abnormal_adipose_tissue0.85636393
78MP0008877_abnormal_DNA_methylation0.84697279
79MP0002332_abnormal_exercise_endurance0.84234391
80MP0000631_abnormal_neuroendocrine_gland0.83748020
81MP0010329_abnormal_lipoprotein_level0.82410634
82MP0004043_abnormal_pH_regulation0.81876434
83MP0002876_abnormal_thyroid_physiology0.79972130
84MP0002733_abnormal_thermal_nociception0.79871911
85MP0002972_abnormal_cardiac_muscle0.78391702
86MP0009115_abnormal_fat_cell0.78271171
87MP0000427_abnormal_hair_cycle0.78269531
88MP0002106_abnormal_muscle_physiology0.78171117
89MP0008775_abnormal_heart_ventricle0.76680071
90MP0002971_abnormal_brown_adipose0.76184758
91MP0003698_abnormal_male_reproductive0.76093241
92MP0002882_abnormal_neuron_morphology0.75978416
93MP0001502_abnormal_circadian_rhythm0.75305072
94MP0000955_abnormal_spinal_cord0.74095278
95MP0001485_abnormal_pinna_reflex0.73762824
96MP0000647_abnormal_sebaceous_gland0.72229794
97MP0002234_abnormal_pharynx_morphology0.72177844
98MP0002184_abnormal_innervation0.70583519
99MP0002066_abnormal_motor_capabilities/c0.69909638
100MP0008961_abnormal_basal_metabolism0.69364396

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)4.19237171
2Febrile seizures (HP:0002373)3.51102940
3Progressive cerebellar ataxia (HP:0002073)3.11500709
4Tubulointerstitial nephritis (HP:0001970)3.10766159
5Genetic anticipation (HP:0003743)3.08527760
6Atonic seizures (HP:0010819)3.00521842
7Hyperventilation (HP:0002883)2.90195241
8Hyperkalemia (HP:0002153)2.86474726
9Drooling (HP:0002307)2.85588199
10Chronic hepatic failure (HP:0100626)2.75406771
11Urinary bladder sphincter dysfunction (HP:0002839)2.73618110
12Gaze-evoked nystagmus (HP:0000640)2.72609947
13Truncal obesity (HP:0001956)2.71762660
14Urinary urgency (HP:0000012)2.62892616
15Hepatoblastoma (HP:0002884)2.60113939
16Termporal pattern (HP:0011008)2.59685511
17Insidious onset (HP:0003587)2.59685511
18Acanthocytosis (HP:0001927)2.55235360
19Excessive salivation (HP:0003781)2.50461558
20Impaired vibration sensation in the lower limbs (HP:0002166)2.47496497
21Thyroid carcinoma (HP:0002890)2.47305340
22Astrocytoma (HP:0009592)2.45678391
23Abnormality of the astrocytes (HP:0100707)2.45678391
24Dysmetric saccades (HP:0000641)2.45064073
25Broad-based gait (HP:0002136)2.41024581
26Epileptiform EEG discharges (HP:0011182)2.35567957
27Fair hair (HP:0002286)2.33962567
28Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.32654805
29Degeneration of the lateral corticospinal tracts (HP:0002314)2.32654805
30Bundle branch block (HP:0011710)2.31712598
31Aplasia/Hypoplasia of the tibia (HP:0005772)2.30110312
32Focal seizures (HP:0007359)2.25843675
33Insulin-resistant diabetes mellitus (HP:0000831)2.22778825
34EEG with generalized epileptiform discharges (HP:0011198)2.22772773
35Sudden death (HP:0001699)2.22586306
36Right ventricular cardiomyopathy (HP:0011663)2.21616770
37Focal motor seizures (HP:0011153)2.19468534
38Subaortic stenosis (HP:0001682)2.17552501
39Abnormality of the left ventricular outflow tract (HP:0011103)2.17552501
40Medulloblastoma (HP:0002885)2.17372226
41Hypsarrhythmia (HP:0002521)2.16458711
42Abnormality of the ischium (HP:0003174)2.13803813
43Hypoplastic labia majora (HP:0000059)2.12631880
44Blue irides (HP:0000635)2.09405170
45Myokymia (HP:0002411)2.07439982
46Abnormality of the corticospinal tract (HP:0002492)2.06970181
47Overgrowth (HP:0001548)2.06770746
48Abnormality of the labia majora (HP:0012881)2.04499324
49Spastic gait (HP:0002064)2.02449269
50Absence seizures (HP:0002121)2.02143621
51Impaired social interactions (HP:0000735)2.02125859
52Abnormal social behavior (HP:0012433)2.02125859
53Dialeptic seizures (HP:0011146)1.99654026
54Syncope (HP:0001279)1.98923692
55Biliary tract neoplasm (HP:0100574)1.97105170
56Action tremor (HP:0002345)1.97056262
57Neoplasm of the heart (HP:0100544)1.97036859
58Generalized hypopigmentation of hair (HP:0011358)1.96477473
59Poor eye contact (HP:0000817)1.96184749
60Epileptic encephalopathy (HP:0200134)1.95487286
61Abnormal auditory evoked potentials (HP:0006958)1.93058644
62Poor coordination (HP:0002370)1.92806472
63Glioma (HP:0009733)1.92553117
64Nemaline bodies (HP:0003798)1.89649429
65Protruding tongue (HP:0010808)1.88776859
66Abnormality of potassium homeostasis (HP:0011042)1.88286924
67Renal cortical cysts (HP:0000803)1.87698995
68Impaired vibratory sensation (HP:0002495)1.87633578
69Decreased circulating renin level (HP:0003351)1.86736682
70Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.85081562
71Thyroid-stimulating hormone excess (HP:0002925)1.84756100
72Abnormality of the axillary hair (HP:0100134)1.83886618
73Abnormality of secondary sexual hair (HP:0009888)1.83886618
74Hyporeflexia of lower limbs (HP:0002600)1.83487017
75Absent eyebrow (HP:0002223)1.83247265
76Neoplasm of striated muscle (HP:0009728)1.82930104
77Genital tract atresia (HP:0001827)1.82901529
78Abnormality of the fingertips (HP:0001211)1.82372706
79Lower limb muscle weakness (HP:0007340)1.82088394
80Rhabdomyosarcoma (HP:0002859)1.80730605
81Muscle fiber inclusion bodies (HP:0100299)1.80361829
82Absent eyelashes (HP:0000561)1.79768453
83Postural instability (HP:0002172)1.78271352
84Volvulus (HP:0002580)1.78056623
85Acute myeloid leukemia (HP:0004808)1.77370602
86Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.77133716
87Papilledema (HP:0001085)1.76866128
88Vaginal atresia (HP:0000148)1.76030254
89Decreased lacrimation (HP:0000633)1.74181910
90Abnormality of the renal cortex (HP:0011035)1.72086243
91Short chin (HP:0000331)1.71450607
92Autoamputation (HP:0001218)1.71265936
93Short tibia (HP:0005736)1.70665062
94Calf muscle hypertrophy (HP:0008981)1.70056635
95Cystic hygroma (HP:0000476)1.69257750
96Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.67267189
97Neoplasm of the small intestine (HP:0100833)1.66544109
98Failure to thrive in infancy (HP:0001531)1.66123316
99Hypoalphalipoproteinemia (HP:0003233)1.65823179
100Difficulty running (HP:0009046)1.65577921

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT33.37824678
2MAP3K43.14292812
3CAMK1G2.67979307
4FRK2.55728649
5ZAK2.34260499
6CAMK1D2.30794582
7CASK2.20733006
8OBSCN2.16020509
9SGK22.09488012
10MAP2K71.98803707
11STK391.96293570
12TLK11.78296350
13EPHA31.72583701
14SGK2231.67950391
15SGK4941.67950391
16EPHA41.67049972
17BRD41.63070338
18NTRK31.61228947
19CSNK1A1L1.52293137
20MARK11.45282997
21FER1.41409230
22NLK1.40831765
23SGK31.38807072
24CDK121.37642579
25PIK3CG1.34106258
26CAMKK21.26684500
27ACVR1B1.24037425
28CAMK41.18707023
29CSNK1G11.17854686
30WNK11.17730459
31PLK21.14710052
32MAPK131.13511595
33MAP4K21.13292251
34CAMK11.10607612
35STK381.09258785
36PINK11.08193949
37PIK3CA1.07434474
38PLK41.07016077
39PRKAA21.05322209
40BMPR1B1.05048128
41LATS11.02022868
42PRKAA10.99467724
43MAP2K40.98070134
44MST40.96295470
45MET0.95659881
46SCYL20.93396341
47CSNK1G20.92925760
48BCR0.90825114
49MARK20.90505488
50CSNK1G30.90414894
51ERBB30.87581596
52PAK60.86276916
53PHKG20.86160585
54PHKG10.86160585
55STK38L0.86159361
56RPS6KA50.84082820
57SGK10.83748303
58TNIK0.83181683
59WNK30.83037426
60NEK60.82736216
61PAK30.81181881
62PKN10.79949102
63NTRK20.79283915
64OXSR10.75571156
65MAP3K20.74453778
66TAOK30.74261601
67MAP3K60.73250943
68INSRR0.72781903
69PRKCE0.70446992
70CDK50.67194544
71TEC0.65680548
72WNK40.65523266
73BRSK20.62288916
74RPS6KA30.60539906
75MYLK0.59546445
76CAMK2A0.57001438
77MST1R0.56449968
78MAPK100.55758373
79PRKD30.55636015
80TIE10.54738267
81DAPK20.53313958
82DMPK0.51973683
83PRKG10.50281917
84BMPR20.50137213
85MELK0.49640181
86DAPK30.48331479
87RET0.47029467
88CDK30.46519763
89MINK10.46175235
90CSNK1D0.45514387
91STK110.45428433
92CAMK2B0.45005511
93VRK10.44981345
94PDGFRB0.43852961
95ERBB20.43138478
96JAK10.42756830
97GSK3B0.41976208
98PRKCB0.41704196
99MAP3K70.41315360
100PRKACB0.40416405

Predicted pathways (KEGG)

RankGene SetZ-score
1Alcoholism_Homo sapiens_hsa050343.27365826
2Systemic lupus erythematosus_Homo sapiens_hsa053223.05845637
3Nicotine addiction_Homo sapiens_hsa050332.79941444
4Fatty acid biosynthesis_Homo sapiens_hsa000612.20637193
5Circadian rhythm_Homo sapiens_hsa047102.11430409
6GABAergic synapse_Homo sapiens_hsa047271.91120798
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.86342131
8Morphine addiction_Homo sapiens_hsa050321.80461717
9Circadian entrainment_Homo sapiens_hsa047131.68415233
10Glutamatergic synapse_Homo sapiens_hsa047241.57171008
11Long-term potentiation_Homo sapiens_hsa047201.43178261
12Insulin secretion_Homo sapiens_hsa049111.42460505
13Synaptic vesicle cycle_Homo sapiens_hsa047211.40883395
14Serotonergic synapse_Homo sapiens_hsa047261.40125245
15Dopaminergic synapse_Homo sapiens_hsa047281.38957252
16Amphetamine addiction_Homo sapiens_hsa050311.35026539
17Taste transduction_Homo sapiens_hsa047421.33827927
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.33369931
19Olfactory transduction_Homo sapiens_hsa047401.32564968
20Adherens junction_Homo sapiens_hsa045201.30049703
21Phosphatidylinositol signaling system_Homo sapiens_hsa040701.27831884
22Renin secretion_Homo sapiens_hsa049241.24289459
23Salivary secretion_Homo sapiens_hsa049701.21450197
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.18640515
25Long-term depression_Homo sapiens_hsa047301.14872748
26Vascular smooth muscle contraction_Homo sapiens_hsa042701.14447963
27Calcium signaling pathway_Homo sapiens_hsa040201.13916689
28Pancreatic secretion_Homo sapiens_hsa049721.11712570
29Renin-angiotensin system_Homo sapiens_hsa046141.11118433
30Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.08999442
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.06019513
32Arginine biosynthesis_Homo sapiens_hsa002201.04167063
33Gap junction_Homo sapiens_hsa045401.03602046
34Cholinergic synapse_Homo sapiens_hsa047251.02666324
35cAMP signaling pathway_Homo sapiens_hsa040241.00753574
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.00657213
37Gastric acid secretion_Homo sapiens_hsa049710.97501641
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95861190
39Dilated cardiomyopathy_Homo sapiens_hsa054140.95656110
40Type II diabetes mellitus_Homo sapiens_hsa049300.95249166
41cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95197482
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.93107415
43Oxytocin signaling pathway_Homo sapiens_hsa049210.90913849
44Inositol phosphate metabolism_Homo sapiens_hsa005620.89877577
45Cocaine addiction_Homo sapiens_hsa050300.88988690
46Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87661474
47Tight junction_Homo sapiens_hsa045300.87636609
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85393102
49Glioma_Homo sapiens_hsa052140.83906394
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83852373
51Platelet activation_Homo sapiens_hsa046110.81812111
52Fat digestion and absorption_Homo sapiens_hsa049750.81777402
53Lysine degradation_Homo sapiens_hsa003100.81417739
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81368990
55ABC transporters_Homo sapiens_hsa020100.80526271
56Propanoate metabolism_Homo sapiens_hsa006400.77982962
57Steroid hormone biosynthesis_Homo sapiens_hsa001400.76950800
58Glucagon signaling pathway_Homo sapiens_hsa049220.76356196
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.75998011
60Vitamin B6 metabolism_Homo sapiens_hsa007500.75069702
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73670393
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73594057
63Choline metabolism in cancer_Homo sapiens_hsa052310.71976164
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71877770
65Fatty acid metabolism_Homo sapiens_hsa012120.71503687
66Butanoate metabolism_Homo sapiens_hsa006500.71054929
67Viral carcinogenesis_Homo sapiens_hsa052030.69444198
68Oocyte meiosis_Homo sapiens_hsa041140.69394391
69ErbB signaling pathway_Homo sapiens_hsa040120.68536979
70PPAR signaling pathway_Homo sapiens_hsa033200.68426308
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68292854
72Linoleic acid metabolism_Homo sapiens_hsa005910.67775240
73Nitrogen metabolism_Homo sapiens_hsa009100.67501579
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64659061
75Dorso-ventral axis formation_Homo sapiens_hsa043200.64551478
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63755814
77AMPK signaling pathway_Homo sapiens_hsa041520.63423840
78ECM-receptor interaction_Homo sapiens_hsa045120.63154525
79Bile secretion_Homo sapiens_hsa049760.61708762
80Glycerolipid metabolism_Homo sapiens_hsa005610.61107296
81TGF-beta signaling pathway_Homo sapiens_hsa043500.59074725
82Sphingolipid metabolism_Homo sapiens_hsa006000.58822474
83Thyroid cancer_Homo sapiens_hsa052160.58725667
84Insulin signaling pathway_Homo sapiens_hsa049100.58590732
85beta-Alanine metabolism_Homo sapiens_hsa004100.58580971
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56636690
87Ovarian steroidogenesis_Homo sapiens_hsa049130.56516238
88Arginine and proline metabolism_Homo sapiens_hsa003300.55854940
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.54774536
90Thyroid hormone synthesis_Homo sapiens_hsa049180.54439809
91FoxO signaling pathway_Homo sapiens_hsa040680.53440855
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.52643156
93Hippo signaling pathway_Homo sapiens_hsa043900.52311373
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50952843
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50934731
96Insulin resistance_Homo sapiens_hsa049310.49713138
97GnRH signaling pathway_Homo sapiens_hsa049120.48670764
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48150481
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47728739
100Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47066574

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