MTRF1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene plays a role in mitochondrial translation termination, and is thought to be a release factor that is involved in the dissociation of the complete protein from the final tRNA, the ribosome, and the cognate mRNA. This protein acts upon UAA and UAG stop codons, but has no in vitro activity against UGA, which encodes tryptophan in human mitochondrion, or, the mitochondrial non-cognate stop codons, AGA and AGG. This protein shares sequence similarity to bacterial release factors. Pseudogenes of this gene are found on chromosomes 4, 8, and 11. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.22532525
2protein neddylation (GO:0045116)5.22070140
3ribosomal small subunit assembly (GO:0000028)5.00674305
4deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.50468897
5response to nitrosative stress (GO:0051409)4.44770609
6telomere maintenance via semi-conservative replication (GO:0032201)4.44654391
7DNA strand elongation involved in DNA replication (GO:0006271)4.35710353
8regulation of DNA endoreduplication (GO:0032875)4.34253629
9DNA replication initiation (GO:0006270)4.20878436
10DNA strand elongation (GO:0022616)4.16781898
11viral transcription (GO:0019083)4.09486271
12* translational termination (GO:0006415)4.00592006
13regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.96619845
14telomere maintenance via recombination (GO:0000722)3.90479192
15SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.76486512
16mitotic recombination (GO:0006312)3.76361000
17DNA unwinding involved in DNA replication (GO:0006268)3.70827477
18CENP-A containing nucleosome assembly (GO:0034080)3.70035425
19negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.69199135
20synapsis (GO:0007129)3.67166766
21cotranslational protein targeting to membrane (GO:0006613)3.64706763
22maturation of 5.8S rRNA (GO:0000460)3.64385915
23protein targeting to ER (GO:0045047)3.63067158
24DNA replication checkpoint (GO:0000076)3.55673666
25translational elongation (GO:0006414)3.54412351
26telomere maintenance via telomere lengthening (GO:0010833)3.51132713
27chromatin remodeling at centromere (GO:0031055)3.50354039
28negative regulation of thymocyte apoptotic process (GO:0070244)3.49351132
29establishment of protein localization to endoplasmic reticulum (GO:0072599)3.48794733
30regulation of oxidative stress-induced neuron death (GO:1903203)3.44363967
31kinetochore organization (GO:0051383)3.43799329
32protein localization to endoplasmic reticulum (GO:0070972)3.41488846
33mitochondrial calcium ion transport (GO:0006851)3.37657401
34negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.36786173
35translational initiation (GO:0006413)3.36310738
36DNA replication-independent nucleosome organization (GO:0034724)3.33756075
37DNA replication-independent nucleosome assembly (GO:0006336)3.33756075
38maturation of SSU-rRNA (GO:0030490)3.32813568
39protein K6-linked ubiquitination (GO:0085020)3.32549489
40nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.30583440
41ribosomal small subunit biogenesis (GO:0042274)3.23983033
42regulation of acyl-CoA biosynthetic process (GO:0050812)3.20662526
43nucleotide-excision repair, DNA gap filling (GO:0006297)3.17118733
44prenylation (GO:0097354)3.16758739
45protein prenylation (GO:0018342)3.16758739
46regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.15966245
47formation of translation preinitiation complex (GO:0001731)3.15369885
48regulation of cofactor metabolic process (GO:0051193)3.13666388
49regulation of coenzyme metabolic process (GO:0051196)3.13666388
50negative regulation of DNA-dependent DNA replication (GO:2000104)3.13397687
51proteasome assembly (GO:0043248)3.13048677
52polyamine metabolic process (GO:0006595)3.12687186
53negative regulation of norepinephrine secretion (GO:0010700)3.12187012
54protein localization to kinetochore (GO:0034501)3.10639224
55spindle assembly involved in mitosis (GO:0090307)3.08973204
56amine catabolic process (GO:0009310)3.08699124
57cellular biogenic amine catabolic process (GO:0042402)3.08699124
58protein K11-linked deubiquitination (GO:0035871)3.08373225
59ribosomal large subunit biogenesis (GO:0042273)3.08105848
60purine-containing compound salvage (GO:0043101)3.04279621
61regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.03997921
62regulation of nuclear cell cycle DNA replication (GO:0033262)3.03632173
63translesion synthesis (GO:0019985)3.02207691
64* cellular protein complex disassembly (GO:0043624)3.01998795
65viral life cycle (GO:0019058)3.01652919
66metaphase plate congression (GO:0051310)3.00475289
67exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.98318790
68telomere organization (GO:0032200)2.95512639
69telomere maintenance (GO:0000723)2.95443742
70histone mRNA metabolic process (GO:0008334)2.95175793
71L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.95095892
72folic acid-containing compound biosynthetic process (GO:0009396)2.94598701
73cysteine metabolic process (GO:0006534)2.94550547
74positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.93364147
75positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.93239500
76nuclear-transcribed mRNA catabolic process (GO:0000956)2.93091717
77antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.93048142
78methionine biosynthetic process (GO:0009086)2.90936429
79antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.89582891
80antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.89582891
81amino acid salvage (GO:0043102)2.89496843
82L-methionine salvage (GO:0071267)2.89496843
83L-methionine biosynthetic process (GO:0071265)2.89496843
84pteridine-containing compound biosynthetic process (GO:0042559)2.89249189
85regulation of penile erection (GO:0060405)2.89079158
86positive regulation of gamma-delta T cell activation (GO:0046645)2.89069896
87regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.85992921
88mitotic sister chromatid cohesion (GO:0007064)2.85147057
89IMP biosynthetic process (GO:0006188)2.84711503
90pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.84386535
91protein localization to chromosome, centromeric region (GO:0071459)2.84280304
92thrombin receptor signaling pathway (GO:0070493)2.84216529
93rRNA processing (GO:0006364)2.83847878
94mRNA catabolic process (GO:0006402)2.83434343
95angiogenesis involved in wound healing (GO:0060055)2.82741912
96microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.81745396
97ribonucleoprotein complex biogenesis (GO:0022613)2.81332707
98SMAD protein complex assembly (GO:0007183)2.81277532
99translation (GO:0006412)2.81250961
100attachment of spindle microtubules to kinetochore (GO:0008608)2.80155452
101pseudouridine synthesis (GO:0001522)2.79975576
102mitotic chromosome condensation (GO:0007076)2.79479374
103nucleobase biosynthetic process (GO:0046112)2.79191400
104nucleobase-containing small molecule interconversion (GO:0015949)2.79001039
105kinetochore assembly (GO:0051382)2.78694432
106RNA catabolic process (GO:0006401)2.78118543
107nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.76723689
108rRNA metabolic process (GO:0016072)2.76610228
109regulation of integrin-mediated signaling pathway (GO:2001044)2.74790904
110replication fork processing (GO:0031297)2.74204181
111establishment of chromosome localization (GO:0051303)2.72273656
112positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.71983166
113regulation of lipoprotein metabolic process (GO:0050746)2.71899448
114negative regulation of protein localization to cell surface (GO:2000009)2.71620034
115regulation of oxidative phosphorylation (GO:0002082)2.70519740
116histone mRNA catabolic process (GO:0071044)2.70383432
117negative regulation of RNA splicing (GO:0033119)2.70319836
118* protein complex disassembly (GO:0043241)2.69798989
119IMP metabolic process (GO:0046040)2.69739383
120methionine metabolic process (GO:0006555)2.69681629
121somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.69151838
122isotype switching (GO:0045190)2.69151838
123somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.69151838
124mitotic G2/M transition checkpoint (GO:0044818)2.68807577
125regulation of Golgi to plasma membrane protein transport (GO:0042996)2.67603390
126DNA damage response, detection of DNA damage (GO:0042769)2.66867645
127histone exchange (GO:0043486)2.65984742
128aspartate family amino acid biosynthetic process (GO:0009067)2.63813264
129postreplication repair (GO:0006301)2.62949449
130tRNA methylation (GO:0030488)2.60724573
131definitive hemopoiesis (GO:0060216)2.60526205
132protein maturation by protein folding (GO:0022417)2.60404860
133mitotic G2 DNA damage checkpoint (GO:0007095)2.58146288
1343-UTR-mediated mRNA stabilization (GO:0070935)2.57749192
135ribosome biogenesis (GO:0042254)2.57675436
136heart process (GO:0003015)2.57111160
137heart contraction (GO:0060047)2.57111160
138tRNA modification (GO:0006400)2.56770993
139DNA duplex unwinding (GO:0032508)2.55979724
140pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.55926609
141pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.55611155
142* macromolecular complex disassembly (GO:0032984)2.55477903
143negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.55152882
144cellular response to zinc ion (GO:0071294)2.54583294
145meiotic chromosome segregation (GO:0045132)2.53819578
146Arp2/3 complex-mediated actin nucleation (GO:0034314)2.53715669
147pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.52971790
148purine nucleobase biosynthetic process (GO:0009113)2.52878146
149deoxyribonucleotide biosynthetic process (GO:0009263)2.52319511
150ribosome assembly (GO:0042255)2.52215656
151DNA geometric change (GO:0032392)2.51932823
152establishment of integrated proviral latency (GO:0075713)2.51636095
153mitotic metaphase plate congression (GO:0007080)2.50799227
154negative regulation of heart rate (GO:0010459)2.50385919
155purine nucleotide salvage (GO:0032261)2.50357035
156DNA topological change (GO:0006265)2.49862961
157mitotic spindle organization (GO:0007052)2.49672800
158regulation of mitochondrial translation (GO:0070129)2.49291120
159negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.49283027
160regulation of centriole replication (GO:0046599)2.48990660
161protein-cofactor linkage (GO:0018065)2.47872432
162nuclear pore organization (GO:0006999)2.46462244
163microtubule depolymerization (GO:0007019)2.46411965
164snRNA transcription (GO:0009301)2.45009933
165regulation of type B pancreatic cell apoptotic process (GO:2000674)2.43571554
166spindle assembly (GO:0051225)2.42824161
167coenzyme A biosynthetic process (GO:0015937)2.42818366
168ether lipid metabolic process (GO:0046485)2.42004319
169response to redox state (GO:0051775)2.41751297
170pyrimidine nucleotide catabolic process (GO:0006244)2.41285972
171high-density lipoprotein particle remodeling (GO:0034375)2.40273395
172regulation of DNA-dependent DNA replication (GO:0090329)2.40225653
173skeletal muscle tissue regeneration (GO:0043403)2.37434366
174mitochondrial calcium ion homeostasis (GO:0051560)2.37288659

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.44352290
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.74328686
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.70387215
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.28590509
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.07650510
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.83747795
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.70041039
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.58105432
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.54573853
10* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.54486325
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.54109298
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.52474236
13EWS_26573619_Chip-Seq_HEK293_Human2.51988877
14* GABP_17652178_ChIP-ChIP_JURKAT_Human2.51734234
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.44243625
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.42577518
17GBX2_23144817_ChIP-Seq_PC3_Human2.36735205
18VDR_23849224_ChIP-Seq_CD4+_Human2.35115210
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.34764531
20TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.24826798
21FOXP3_21729870_ChIP-Seq_TREG_Human2.21495975
22MYC_22102868_ChIP-Seq_BL_Human2.21144293
23POU3F2_20337985_ChIP-ChIP_501MEL_Human2.16480389
24IRF8_22096565_ChIP-ChIP_GC-B_Human2.13503838
25MYC_19079543_ChIP-ChIP_MESCs_Mouse2.12518246
26IGF1R_20145208_ChIP-Seq_DFB_Human2.11532350
27TAF15_26573619_Chip-Seq_HEK293_Human2.10734691
28CREB1_15753290_ChIP-ChIP_HEK293T_Human2.09958401
29NOTCH1_21737748_ChIP-Seq_TLL_Human2.08699129
30IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.07334112
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.07264382
32SCL_19346495_ChIP-Seq_HPC-7_Human2.03237828
33CIITA_25753668_ChIP-Seq_RAJI_Human2.01867583
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.98964740
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.96816381
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.95588671
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.95340668
38* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.94973433
39* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.93928275
40SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.92764682
41FUS_26573619_Chip-Seq_HEK293_Human1.91201904
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.88261440
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.88019511
44SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.87384147
45* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.86057498
46DCP1A_22483619_ChIP-Seq_HELA_Human1.85441791
47AR_21909140_ChIP-Seq_LNCAP_Human1.84346976
48MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.81709938
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.81313076
50XRN2_22483619_ChIP-Seq_HELA_Human1.80082265
51VDR_21846776_ChIP-Seq_THP-1_Human1.76949372
52* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.75589505
53CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.74619362
54* GABP_19822575_ChIP-Seq_HepG2_Human1.70489320
55GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.66748784
56ELK1_19687146_ChIP-ChIP_HELA_Human1.66725794
57* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.66075861
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64594072
59* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.64315827
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.64188608
61SPI1_23547873_ChIP-Seq_NB4_Human1.63688503
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.62057047
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.58546461
64SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.56873438
65MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.54838636
66SRF_21415370_ChIP-Seq_HL-1_Mouse1.53599355
67MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.50554044
68* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49492589
69YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49203613
70MYCN_18555785_ChIP-Seq_MESCs_Mouse1.47964482
71TTF2_22483619_ChIP-Seq_HELA_Human1.46687533
72MYB_21317192_ChIP-Seq_ERMYB_Mouse1.44551857
73RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.40465737
74SALL1_21062744_ChIP-ChIP_HESCs_Human1.31463673
75RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31249311
76YY1_21170310_ChIP-Seq_MESCs_Mouse1.30989850
77* MYC_18940864_ChIP-ChIP_HL60_Human1.29391902
78MYB_26560356_Chip-Seq_TH2_Human1.28177268
79MYB_26560356_Chip-Seq_TH1_Human1.27878474
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27367675
81HTT_18923047_ChIP-ChIP_STHdh_Human1.26340644
82KDM5A_27292631_Chip-Seq_BREAST_Human1.24958539
83NANOG_18555785_ChIP-Seq_MESCs_Mouse1.23961574
84STAT4_19710469_ChIP-ChIP_TH1__Mouse1.23883788
85VDR_22108803_ChIP-Seq_LS180_Human1.22800682
86EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22042500
87* EZH2_27294783_Chip-Seq_NPCs_Mouse1.20949666
88PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20918393
89PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.19933852
90TFEB_21752829_ChIP-Seq_HELA_Human1.19920871
91P300_19829295_ChIP-Seq_ESCs_Human1.19405238
92GATA1_22025678_ChIP-Seq_K562_Human1.18898145
93E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17288195
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16773298
95ER_23166858_ChIP-Seq_MCF-7_Human1.15932548
96VDR_24763502_ChIP-Seq_THP-1_Human1.15883096
97GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15448942
98PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15190349
99GATA4_21415370_ChIP-Seq_HL-1_Mouse1.13372222
100STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.12043306
101MAF_26560356_Chip-Seq_TH1_Human1.11988691
102BRD4_25478319_ChIP-Seq_HGPS_Human1.11604976
103CDX2_22108803_ChIP-Seq_LS180_Human1.10792947
104KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.10497113
105CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10312931
106RUNX1_22412390_ChIP-Seq_EML_Mouse1.09815436
107CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09575547
108PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08805028
109BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.08131416
110FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.08050117
111SALL4_22934838_ChIP-ChIP_CD34+_Human1.07555191
112UTX_26944678_Chip-Seq_JUKART_Human1.06643889
113MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06309350
114GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06004775
115AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05871178
116POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.05104071
117TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04078272
118CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03450253
119SMAD4_21799915_ChIP-Seq_A2780_Human1.00459742
120* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98619809
121RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97969710
122* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97557899
123OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96633145
124DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96460379
125WT1_19549856_ChIP-ChIP_CCG9911_Human0.96314748
126SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95846096
127TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95815814
128CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95138193
129SALL4_18804426_ChIP-ChIP_XEN_Mouse0.94727966
130TP63_19390658_ChIP-ChIP_HaCaT_Human0.93569938
131FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.93359440
132NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93258847
133NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93258847
134* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.93182512
135CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.92299283
136CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92178016
137MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.91750317
138TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.91132287
139LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90827062
140FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.90609087
141* CRX_20693478_ChIP-Seq_RETINA_Mouse0.90417891
142TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89917980
143MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89814206
144ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89778166
145SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.89509466
146TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.89453518
147SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.87483259
148* GATA2_21666600_ChIP-Seq_HMVEC_Human0.86099502
149CBP_20019798_ChIP-Seq_JUKART_Human0.85696634
150IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.85696634
151JUN_21703547_ChIP-Seq_K562_Human0.84061558

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.68872412
2MP0010094_abnormal_chromosome_stability3.42904347
3MP0002396_abnormal_hematopoietic_system3.25104563
4MP0008057_abnormal_DNA_replication3.03694244
5MP0003111_abnormal_nucleus_morphology2.99687639
6MP0003077_abnormal_cell_cycle2.99048857
7MP0003763_abnormal_thymus_physiology2.91192636
8MP0004957_abnormal_blastocyst_morpholog2.83893096
9MP0008004_abnormal_stomach_pH2.77641743
10MP0008058_abnormal_DNA_repair2.46244901
11MP0004808_abnormal_hematopoietic_stem2.46138681
12MP0003950_abnormal_plasma_membrane2.42890613
13MP0002837_dystrophic_cardiac_calcinosis2.38058946
14MP0008007_abnormal_cellular_replicative2.34629123
15MP0001879_abnormal_lymphatic_vessel2.27302595
16MP0003656_abnormal_erythrocyte_physiolo2.21044593
17MP0000569_abnormal_digit_pigmentation2.20492349
18MP0002102_abnormal_ear_morphology2.14580236
19MP0005671_abnormal_response_to2.13630272
20MP0000490_abnormal_crypts_of2.12796271
21MP0002398_abnormal_bone_marrow2.11621304
22MP0005397_hematopoietic_system_phenotyp1.96021235
23MP0001545_abnormal_hematopoietic_system1.96021235
24MP0010368_abnormal_lymphatic_system1.94221295
25MP0005423_abnormal_somatic_nervous1.89475641
26MP0002009_preneoplasia1.86371453
27MP0000703_abnormal_thymus_morphology1.85966485
28MP0001800_abnormal_humoral_immune1.85885271
29MP0001835_abnormal_antigen_presentation1.83756595
30MP0002722_abnormal_immune_system1.80317934
31MP0000685_abnormal_immune_system1.79002491
32MP0000689_abnormal_spleen_morphology1.77827238
33MP0006054_spinal_hemorrhage1.72887097
34MP0004036_abnormal_muscle_relaxation1.71945399
35MP0003567_abnormal_fetal_cardiomyocyte1.70299849
36MP0002166_altered_tumor_susceptibility1.68882307
37MP0002420_abnormal_adaptive_immunity1.66015738
38MP0000716_abnormal_immune_system1.65449777
39MP0003718_maternal_effect1.64306926
40MP0001819_abnormal_immune_cell1.61565419
41MP0002429_abnormal_blood_cell1.60702543
42MP0002452_abnormal_antigen_presenting1.59992392
43MP0005075_abnormal_melanosome_morpholog1.58718079
44MP0004215_abnormal_myocardial_fiber1.55423847
45MP0009333_abnormal_splenocyte_physiolog1.54139334
46MP0003646_muscle_fatigue1.53871928
47MP0002723_abnormal_immune_serum1.52967830
48MP0002019_abnormal_tumor_incidence1.51553306
49MP0002876_abnormal_thyroid_physiology1.45879331
50MP0003136_yellow_coat_color1.45271340
51MP0001873_stomach_inflammation1.45214500
52MP0002160_abnormal_reproductive_system1.44658743
53MP0000230_abnormal_systemic_arterial1.43822846
54MP0006276_abnormal_autonomic_nervous1.42587768
55MP0005025_abnormal_response_to1.41536898
56MP0000465_gastrointestinal_hemorrhage1.40063550
57MP0002972_abnormal_cardiac_muscle1.39555382
58MP0000313_abnormal_cell_death1.38208507
59MP0005620_abnormal_muscle_contractility1.37285345
60MP0006072_abnormal_retinal_apoptosis1.37077923
61MP0009785_altered_susceptibility_to1.36719177
62MP0006036_abnormal_mitochondrial_physio1.36686465
63MP0008932_abnormal_embryonic_tissue1.36178312
64MP0001529_abnormal_vocalization1.35024780
65MP0001299_abnormal_eye_distance/1.34358729
66MP0003806_abnormal_nucleotide_metabolis1.32441662
67MP0005000_abnormal_immune_tolerance1.31483633
68MP0001293_anophthalmia1.31009754
69MP0003123_paternal_imprinting1.30140874
70MP0000350_abnormal_cell_proliferation1.29140363
71MP0000015_abnormal_ear_pigmentation1.27442061
72MP0009840_abnormal_foam_cell1.27235735
73MP0002132_abnormal_respiratory_system1.22972732
74MP0002095_abnormal_skin_pigmentation1.22393806
75MP0001730_embryonic_growth_arrest1.20091530
76MP0003436_decreased_susceptibility_to1.19385235
77MP0000749_muscle_degeneration1.19057379
78MP0002084_abnormal_developmental_patter1.18772573
79MP0004233_abnormal_muscle_weight1.18687195
80MP0000858_altered_metastatic_potential1.17911076
81MP0005174_abnormal_tail_pigmentation1.17045141
82MP0001188_hyperpigmentation1.16974870
83MP0009780_abnormal_chondrocyte_physiolo1.15700780
84MP0002332_abnormal_exercise_endurance1.15176687
85MP0010307_abnormal_tumor_latency1.14969916
86MP0005464_abnormal_platelet_physiology1.14261916
87MP0010155_abnormal_intestine_physiology1.14201234
88MP0005387_immune_system_phenotype1.13358212
89MP0001790_abnormal_immune_system1.13358212
90MP0002405_respiratory_system_inflammati1.12302462
91MP0002419_abnormal_innate_immunity1.12104460
92MP0001986_abnormal_taste_sensitivity1.11316322
93MP0004484_altered_response_of1.11029280
94MP0004085_abnormal_heartbeat1.11009351
95MP0003941_abnormal_skin_development1.09230407
96MP0003866_abnormal_defecation1.08654457
97MP0010352_gastrointestinal_tract_polyps1.08530227
98MP0005187_abnormal_penis_morphology1.08334249
99MP0002006_tumorigenesis1.06437621
100MP0001853_heart_inflammation1.06089038
101MP0003195_calcinosis1.04602856
102MP0004130_abnormal_muscle_cell1.03768419
103MP0002269_muscular_atrophy1.01729415
104MP0005220_abnormal_exocrine_pancreas1.01411599
105MP0002080_prenatal_lethality1.01064513
106MP0002177_abnormal_outer_ear1.01030818
107MP0009697_abnormal_copulation1.00125182
108MP0003221_abnormal_cardiomyocyte_apopto0.99435150
109MP0003172_abnormal_lysosome_physiology0.97549291
110MP0005330_cardiomyopathy0.96790840
111MP0000358_abnormal_cell_content/0.96665807
112MP0003828_pulmonary_edema0.96494410
113MP0003984_embryonic_growth_retardation0.95835698
114MP0004084_abnormal_cardiac_muscle0.95215072
115MP0002088_abnormal_embryonic_growth/wei0.93831479
116MP0003724_increased_susceptibility_to0.93121648
117MP0008877_abnormal_DNA_methylation0.93049057
118MP0003186_abnormal_redox_activity0.92436378
119MP0005385_cardiovascular_system_phenoty0.91311540
120MP0001544_abnormal_cardiovascular_syste0.91311540
121MP0000427_abnormal_hair_cycle0.90773722
122MP0001697_abnormal_embryo_size0.90623323
123MP0001845_abnormal_inflammatory_respons0.90318760
124MP0001286_abnormal_eye_development0.89507133
125MP0003786_premature_aging0.89462477
126MP0001672_abnormal_embryogenesis/_devel0.89082968
127MP0005380_embryogenesis_phenotype0.89082968
128MP0003787_abnormal_imprinting0.88354430
129MP0005389_reproductive_system_phenotype0.86798125
130MP0002210_abnormal_sex_determination0.84449051
131MP0001661_extended_life_span0.83962805
132MP0008469_abnormal_protein_level0.83418392
133MP0001929_abnormal_gametogenesis0.83095166
134MP0005410_abnormal_fertilization0.81417573
135MP0001784_abnormal_fluid_regulation0.80433306
136MP0003385_abnormal_body_wall0.79675706
137MP0006292_abnormal_olfactory_placode0.79377880
138MP0002877_abnormal_melanocyte_morpholog0.79038375
139MP0005084_abnormal_gallbladder_morpholo0.78956770
140MP0004087_abnormal_muscle_fiber0.78493371
141MP0000598_abnormal_liver_morphology0.78077042
142MP0002128_abnormal_blood_circulation0.77128117
143MP0009763_increased_sensitivity_to0.75997862
144MP0002086_abnormal_extraembryonic_tissu0.75721460
145MP0005332_abnormal_amino_acid0.74745787
146MP0005083_abnormal_biliary_tract0.74365962
147MP0004197_abnormal_fetal_growth/weight/0.74241027
148MP0003868_abnormal_feces_composition0.73300987
149MP0006035_abnormal_mitochondrial_morpho0.73029110
150MP0005266_abnormal_metabolism0.71929311
151MP0002933_joint_inflammation0.71918043
152MP0003943_abnormal_hepatobiliary_system0.71329640
153MP0004147_increased_porphyrin_level0.71027302
154MP0002148_abnormal_hypersensitivity_rea0.70699084
155MP0005365_abnormal_bile_salt0.68833244
156MP0008775_abnormal_heart_ventricle0.65491240
157MP0005384_cellular_phenotype0.64776335
158MP0009765_abnormal_xenobiotic_induced0.64650321
159MP0003300_gastrointestinal_ulcer0.63449106

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)5.45241554
2Birth length less than 3rd percentile (HP:0003561)4.42970923
3Hyperkalemia (HP:0002153)4.31176348
4IgM deficiency (HP:0002850)4.29053804
5Thrombocytosis (HP:0001894)3.95525631
6Increased mean platelet volume (HP:0011877)3.92159855
7Menorrhagia (HP:0000132)3.83615395
8Aplastic anemia (HP:0001915)3.82380111
9Decreased circulating renin level (HP:0003351)3.69564553
10Reticulocytopenia (HP:0001896)3.57179052
11Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.50353839
12Abnormality of the heme biosynthetic pathway (HP:0010472)3.45687696
13Hyperactive renin-angiotensin system (HP:0000841)3.44933782
14Muscle fiber inclusion bodies (HP:0100299)3.44434838
15Abnormal number of erythroid precursors (HP:0012131)3.43837934
16Abnormality of cells of the erythroid lineage (HP:0012130)3.41241957
17Nemaline bodies (HP:0003798)3.36073490
18Abnormal platelet volume (HP:0011876)3.34546591
19Chromsome breakage (HP:0040012)3.26294369
20Toxemia of pregnancy (HP:0100603)3.11242827
21Abnormality of B cell number (HP:0010975)3.08554799
22B lymphocytopenia (HP:0010976)3.08554799
23Papillary thyroid carcinoma (HP:0002895)3.05593081
24Chromosomal breakage induced by crosslinking agents (HP:0003221)3.04730957
25Abnormality of T cell physiology (HP:0011840)3.03062678
26Dyschromatopsia (HP:0007641)2.91865488
27Elevated erythrocyte sedimentation rate (HP:0003565)2.89830033
28Recurrent bronchitis (HP:0002837)2.82970703
29Myelodysplasia (HP:0002863)2.82735277
30Broad face (HP:0000283)2.77871081
31Amaurosis fugax (HP:0100576)2.76436176
32Lymphoma (HP:0002665)2.73061585
33Asplenia (HP:0001746)2.70783841
34Biliary tract neoplasm (HP:0100574)2.70683211
35Bundle branch block (HP:0011710)2.70564155
36Pallor (HP:0000980)2.70373212
37Petechiae (HP:0000967)2.70055840
38Chronic otitis media (HP:0000389)2.69048008
39Abnormality of T cells (HP:0002843)2.67623581
40Ventricular fibrillation (HP:0001663)2.66605867
41Nuclear cataract (HP:0100018)2.63560681
42IgG deficiency (HP:0004315)2.62798944
43Abnormality of chromosome stability (HP:0003220)2.61979698
44Decreased activity of mitochondrial respiratory chain (HP:0008972)2.61124974
45Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.61124974
46Acanthocytosis (HP:0001927)2.58132518
47Neoplasm of the small intestine (HP:0100833)2.55944008
48Abnormality of alanine metabolism (HP:0010916)2.55462180
49Hyperalaninemia (HP:0003348)2.55462180
50Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.55462180
51Microretrognathia (HP:0000308)2.55130133
52Double outlet right ventricle (HP:0001719)2.54699087
53Congenital malformation of the right heart (HP:0011723)2.54699087
54Recurrent viral infections (HP:0004429)2.52616579
55Aplasia/Hypoplasia of the sacrum (HP:0008517)2.50944287
56Microcytic anemia (HP:0001935)2.48341092
57Exertional dyspnea (HP:0002875)2.48163968
58Macrocytic anemia (HP:0001972)2.47857596
59Microvesicular hepatic steatosis (HP:0001414)2.47049061
60Thyroid-stimulating hormone excess (HP:0002925)2.42636590
61Hepatic necrosis (HP:0002605)2.41263179
62Neoplasm of the rectum (HP:0100743)2.39925119
63Poikilocytosis (HP:0004447)2.39618552
64Prolonged bleeding time (HP:0003010)2.39326489
65Metaphyseal dysplasia (HP:0100255)2.38626380
66Hepatocellular necrosis (HP:0001404)2.36148775
67Type I transferrin isoform profile (HP:0003642)2.35687273
68Aplasia/Hypoplasia of the spleen (HP:0010451)2.35341288
69Pancytopenia (HP:0001876)2.32601465
70Tinnitus (HP:0000360)2.32567377
71Neuroendocrine neoplasm (HP:0100634)2.31227783
72Abnormal number of incisors (HP:0011064)2.25790754
73Abnormal auditory evoked potentials (HP:0006958)2.22932085
74Abnormal delayed hypersensitivity skin test (HP:0002963)2.20336396
75Panhypogammaglobulinemia (HP:0003139)2.18993255
76Pancreatic islet-cell hyperplasia (HP:0004510)2.18934111
77Hyperlipoproteinemia (HP:0010980)2.18305191
78Lymphopenia (HP:0001888)2.18006442
79Reduced antithrombin III activity (HP:0001976)2.17256658
80Intestinal atresia (HP:0011100)2.16781625
81Abnormality of cells of the lymphoid lineage (HP:0012140)2.15701726
82T lymphocytopenia (HP:0005403)2.14923144
83Abnormality of the preputium (HP:0100587)2.12339224
84Generalized aminoaciduria (HP:0002909)2.12220893
85Hypoplasia of the thymus (HP:0000778)2.12024477
86Oral leukoplakia (HP:0002745)2.11479265
87Increased hepatocellular lipid droplets (HP:0006565)2.10611072
88Lipid accumulation in hepatocytes (HP:0006561)2.10273483
89Purpura (HP:0000979)2.09657616
90Renal cortical cysts (HP:0000803)2.09208394
91Gastrointestinal stroma tumor (HP:0100723)2.09006415
92Colon cancer (HP:0003003)2.06611444
93Bone marrow hypocellularity (HP:0005528)2.05702594
94Poikiloderma (HP:0001029)2.04262316
95Premature graying of hair (HP:0002216)2.03221985
96Entropion (HP:0000621)2.02535856
97Volvulus (HP:0002580)2.01950421
98Congenital cataract (HP:0000519)2.01822407
99Granulocytopenia (HP:0001913)2.01713500
100Conjunctival telangiectasia (HP:0000524)2.01023110
101Abnormality of lateral ventricle (HP:0030047)2.00987505
102Thyroid carcinoma (HP:0002890)2.00728471
103Exercise-induced muscle cramps (HP:0003710)2.00594983
104Aplasia/Hypoplasia of the thymus (HP:0010515)1.99726295
105Meckel diverticulum (HP:0002245)1.97875803
106Abnormality of potassium homeostasis (HP:0011042)1.97324502
107Abnormality of the columella (HP:0009929)1.97251652
108Recurrent fungal infections (HP:0002841)1.97103185
109Carpal bone hypoplasia (HP:0001498)1.96627318
110Epistaxis (HP:0000421)1.95351981
111Termporal pattern (HP:0011008)1.95111269
112Insidious onset (HP:0003587)1.95111269
113Aplasia/Hypoplasia of the uvula (HP:0010293)1.94927236
114Rimmed vacuoles (HP:0003805)1.92662285
115Abnormality of DNA repair (HP:0003254)1.92432833
116Abnormality of T cell number (HP:0011839)1.91706202
117Hypophosphatemic rickets (HP:0004912)1.90947381
118Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.89857702
119Abnormal protein N-linked glycosylation (HP:0012347)1.89857702
120Abnormal protein glycosylation (HP:0012346)1.89857702
121Abnormal glycosylation (HP:0012345)1.89857702
122Severe combined immunodeficiency (HP:0004430)1.89256295
123Beaking of vertebral bodies (HP:0004568)1.86779363
124Cellulitis (HP:0100658)1.86119758
125Sloping forehead (HP:0000340)1.85994266
126Abnormality of renin-angiotensin system (HP:0000847)1.84956821
127Abnormality of the ileum (HP:0001549)1.84931124
128Clubbing of toes (HP:0100760)1.84453349
129Neoplasm of the colon (HP:0100273)1.84397619
130Dicarboxylic aciduria (HP:0003215)1.83288320
131Abnormality of dicarboxylic acid metabolism (HP:0010995)1.83288320
132Rough bone trabeculation (HP:0100670)1.82734214
133Cortical dysplasia (HP:0002539)1.81934648
134Respiratory difficulties (HP:0002880)1.80197388
135Type 2 muscle fiber atrophy (HP:0003554)1.80079403
136Subaortic stenosis (HP:0001682)1.79611154
137Abnormality of the left ventricular outflow tract (HP:0011103)1.79611154
138Increased serum lactate (HP:0002151)1.79082741
139Central scotoma (HP:0000603)1.78502106
140Small intestinal stenosis (HP:0012848)1.77965917
141Duodenal stenosis (HP:0100867)1.77965917
142Abnormality of reticulocytes (HP:0004312)1.77929097
143Leukopenia (HP:0001882)1.76936378
144Muscle fiber atrophy (HP:0100295)1.76580978
145Progressive hearing impairment (HP:0001730)1.76344386
146Hyperaldosteronism (HP:0000859)1.75254742
147Increased CSF lactate (HP:0002490)1.74868278
148Neutropenia (HP:0001875)1.73543308
149Pheochromocytoma (HP:0002666)1.73266797
150Neoplasm of the pancreas (HP:0002894)1.73240938
151Acute myeloid leukemia (HP:0004808)1.73171746
152Nausea (HP:0002018)1.72420027
153Proximal tubulopathy (HP:0000114)1.72152029
154Basal cell carcinoma (HP:0002671)1.71397603
155Abnormality of the fingertips (HP:0001211)1.71147064
15611 pairs of ribs (HP:0000878)1.71118406
157Hypoglycemic coma (HP:0001325)1.70308263
158Muscle hypertrophy of the lower extremities (HP:0008968)1.69106622
159Progressive muscle weakness (HP:0003323)1.68556942
160Atrioventricular block (HP:0001678)1.66271886
161Triphalangeal thumb (HP:0001199)1.64704112
162Palpitations (HP:0001962)1.63986720
163Abnormality of the duodenum (HP:0002246)1.62563017
164Neoplasm of the peripheral nervous system (HP:0100007)1.62209154
165Calf muscle hypertrophy (HP:0008981)1.61805269
166EMG: myopathic abnormalities (HP:0003458)1.61497900
167Gastrointestinal atresia (HP:0002589)1.60881250
168Abnormal biliary tract morphology (HP:0012440)1.60625630
169Absent radius (HP:0003974)1.60530790
170Delayed puberty (HP:0000823)1.58933704
171Ectopic kidney (HP:0000086)1.58925719
172Severe visual impairment (HP:0001141)1.58678427
173Sensory axonal neuropathy (HP:0003390)1.58313700
174Abnormality of the intrinsic pathway (HP:0010989)1.57639132
175Decreased central vision (HP:0007663)1.57181752
176Hyperthyroidism (HP:0000836)1.57178553
177Abnormal lung lobation (HP:0002101)1.56425945
178Megaloblastic anemia (HP:0001889)1.53317490

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK23.35635277
2WEE13.32043612
3NME23.20657700
4BRSK22.87411947
5MST42.84570085
6MAP4K12.75102009
7EIF2AK12.68118602
8CDC72.67425403
9OBSCN2.49718369
10BMPR1B2.44871676
11EIF2AK32.21894908
12FLT32.13502624
13PNCK2.13497539
14MYLK2.04984769
15ACVR1B2.02684406
16BUB12.00794619
17DYRK32.00332087
18PINK11.94845674
19BCKDK1.85485928
20ZAP701.80958152
21MAP3K91.78844117
22TLK11.78179640
23TEC1.76585739
24TESK21.73991781
25JAK31.71378213
26STK161.70994290
27TIE11.70340418
28PLK21.63988447
29STK391.62073930
30NEK21.59900732
31CDK81.59350505
32BRSK11.59311373
33TXK1.55059876
34WNK31.54746452
35PBK1.53375961
36RPS6KA41.51439707
37ERBB31.48881493
38KIT1.48186396
39FRK1.46130684
40MOS1.42230214
41SRPK11.41858639
42WNK41.41557414
43BTK1.39805002
44NEK11.35321447
45STK31.34899895
46PHKG21.30407416
47PHKG11.30407416
48KDR1.26751955
49ZAK1.23205209
50TRIM281.22508009
51PASK1.20323790
52SIK31.17916254
53AURKB1.16698765
54STK101.16104685
55TNIK1.15987545
56NLK1.15935646
57STK38L1.15742932
58STK41.15345992
59VRK11.14455498
60MKNK11.14311567
61ATR1.14181365
62MAP3K101.13098123
63MAP2K61.13017316
64MAP3K81.12874984
65PIM21.12156075
66IRAK41.11739621
67PIK3CG1.08930486
68PLK11.08475165
69CDK41.07461115
70MAP2K31.02687458
71ILK0.98960536
72MAP2K70.98480414
73CDK70.98453641
74MKNK20.98342689
75PKN20.97642398
76RPS6KB20.97351820
77CDK190.97013247
78PDK20.95700548
79TGFBR10.95490753
80BRD40.95440948
81IKBKE0.94521448
82TBK10.93509869
83LATS10.90893065
84CSF1R0.90564391
85CCNB10.90450739
86CAMKK20.89825537
87BMX0.89748922
88MARK30.88034854
89MAP3K120.86166463
90CHEK20.82500361
91TTK0.82229156
92TYK20.80400116
93CDK30.79920091
94TSSK60.76692447
95PLK40.76258411
96MAP3K40.75489594
97ERN10.75284960
98CAMK1G0.75283438
99NUAK10.75186161
100EEF2K0.74970681
101PAK40.74649838
102CASK0.74189068
103RPS6KA50.73721024
104EIF2AK20.73386406
105LCK0.73367146
106BMPR20.71974718
107DYRK1B0.71198655
108CLK10.71031070
109AKT20.70013294
110PIM10.68692713
111CDK120.68650351
112DMPK0.68090467
113SYK0.67873204
114SCYL20.66839031
115MAP3K50.65127862
116CDK60.63496223
117LRRK20.62699161
118ERBB40.61949381
119OXSR10.61750401
120MINK10.60185351
121TRPM70.57691056
122KSR20.57518023
123NEK90.56842319
124AURKA0.55936113
125CSNK1A1L0.55494798
126MAP3K110.55030543
127LYN0.53499484
128MAPK110.51991029
129MAPKAPK30.50915468
130ATM0.48032669
131STK240.48008347
132MAP3K140.47753438
133CDK90.47741512
134HIPK20.46827478
135IRAK20.46319455
136KSR10.44887369
137CHEK10.43948268
138TAOK30.43663830
139IRAK30.43115211
140PLK30.42184669
141CSNK2A20.41525662
142FES0.41275997
143GRK50.39598195
144CDK20.38471486
145SGK10.38252617
146CSNK1E0.38144119
147ABL20.36871153
148BLK0.36823753
149IRAK10.36689664
150IKBKB0.36605697
151CSNK2A10.36573440
152ARAF0.36038080
153AKT30.36022693
154PAK30.35957875
155FGFR40.35614089
156TGFBR20.35498135
157CDK140.35330939
158PTK2B0.34762970
159BCR0.34722241

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.81522228
2Ribosome_Homo sapiens_hsa030103.65110924
3Mismatch repair_Homo sapiens_hsa034303.61200915
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.85697323
5Homologous recombination_Homo sapiens_hsa034402.77342911
6Spliceosome_Homo sapiens_hsa030402.70682801
7Base excision repair_Homo sapiens_hsa034102.70561552
8Pyrimidine metabolism_Homo sapiens_hsa002402.46228082
9Nucleotide excision repair_Homo sapiens_hsa034202.40112332
10RNA polymerase_Homo sapiens_hsa030202.31987746
11Cell cycle_Homo sapiens_hsa041102.31267302
12Fanconi anemia pathway_Homo sapiens_hsa034602.28629890
13Proteasome_Homo sapiens_hsa030502.19456712
14RNA transport_Homo sapiens_hsa030132.10316274
15Primary immunodeficiency_Homo sapiens_hsa053402.06285725
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.99587362
17One carbon pool by folate_Homo sapiens_hsa006701.95000225
18Non-homologous end-joining_Homo sapiens_hsa034501.88841008
19RNA degradation_Homo sapiens_hsa030181.85985164
20Sulfur relay system_Homo sapiens_hsa041221.74701682
21Protein export_Homo sapiens_hsa030601.65617719
22Circadian rhythm_Homo sapiens_hsa047101.64921820
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.59747011
24Folate biosynthesis_Homo sapiens_hsa007901.52959000
25Antigen processing and presentation_Homo sapiens_hsa046121.50331546
26Sulfur metabolism_Homo sapiens_hsa009201.44810455
27Systemic lupus erythematosus_Homo sapiens_hsa053221.44639374
28Glutathione metabolism_Homo sapiens_hsa004801.40969762
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.40493124
30Herpes simplex infection_Homo sapiens_hsa051681.38782828
31Nitrogen metabolism_Homo sapiens_hsa009101.34129836
32p53 signaling pathway_Homo sapiens_hsa041151.29072436
33Oxidative phosphorylation_Homo sapiens_hsa001901.25078351
34Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.23632484
35Basal transcription factors_Homo sapiens_hsa030221.23247907
36Purine metabolism_Homo sapiens_hsa002301.22183331
37Measles_Homo sapiens_hsa051621.21180145
38Fatty acid elongation_Homo sapiens_hsa000621.18917850
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.17059867
40Steroid biosynthesis_Homo sapiens_hsa001001.16760729
41Epstein-Barr virus infection_Homo sapiens_hsa051691.15919282
42NF-kappa B signaling pathway_Homo sapiens_hsa040641.12319934
43Other glycan degradation_Homo sapiens_hsa005111.08223863
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.04608010
45Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.04228195
46mRNA surveillance pathway_Homo sapiens_hsa030151.03726764
47N-Glycan biosynthesis_Homo sapiens_hsa005100.97392398
48Pentose phosphate pathway_Homo sapiens_hsa000300.93887356
49Viral carcinogenesis_Homo sapiens_hsa052030.93528971
50Selenocompound metabolism_Homo sapiens_hsa004500.90369386
51Hematopoietic cell lineage_Homo sapiens_hsa046400.88705691
52Olfactory transduction_Homo sapiens_hsa047400.88204779
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88123430
54Gap junction_Homo sapiens_hsa045400.86770167
55Phototransduction_Homo sapiens_hsa047440.86535193
56Propanoate metabolism_Homo sapiens_hsa006400.86217944
57Thyroid cancer_Homo sapiens_hsa052160.85943088
58Leishmaniasis_Homo sapiens_hsa051400.85409650
59Adherens junction_Homo sapiens_hsa045200.85323386
60Regulation of autophagy_Homo sapiens_hsa041400.82238252
61Pyruvate metabolism_Homo sapiens_hsa006200.81379241
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.81233981
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.80650120
64TGF-beta signaling pathway_Homo sapiens_hsa043500.80489700
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79806990
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78543446
67B cell receptor signaling pathway_Homo sapiens_hsa046620.78226821
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.78067431
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77006608
70Caffeine metabolism_Homo sapiens_hsa002320.76646741
71HTLV-I infection_Homo sapiens_hsa051660.73862736
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72122696
73Legionellosis_Homo sapiens_hsa051340.71648641
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69604061
75Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.69500258
76T cell receptor signaling pathway_Homo sapiens_hsa046600.68344127
77Small cell lung cancer_Homo sapiens_hsa052220.67707565
78Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67263326
79Hepatitis B_Homo sapiens_hsa051610.65597990
80Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65166966
81Melanoma_Homo sapiens_hsa052180.63514611
82Collecting duct acid secretion_Homo sapiens_hsa049660.63394213
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63297017
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63138222
85Sphingolipid metabolism_Homo sapiens_hsa006000.62147444
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.62088635
87Acute myeloid leukemia_Homo sapiens_hsa052210.61932890
88Cardiac muscle contraction_Homo sapiens_hsa042600.61317388
89Glucagon signaling pathway_Homo sapiens_hsa049220.60782061
90Apoptosis_Homo sapiens_hsa042100.59889472
91Bladder cancer_Homo sapiens_hsa052190.58283699
92Alzheimers disease_Homo sapiens_hsa050100.56949753
93Shigellosis_Homo sapiens_hsa051310.56783355
94Parkinsons disease_Homo sapiens_hsa050120.55779669
95Dilated cardiomyopathy_Homo sapiens_hsa054140.55602955
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55480552
97Osteoclast differentiation_Homo sapiens_hsa043800.54652074
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54212591
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48273134
100Influenza A_Homo sapiens_hsa051640.48246384
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47676548
102Serotonergic synapse_Homo sapiens_hsa047260.47288034
103Renal cell carcinoma_Homo sapiens_hsa052110.46329636
104Dorso-ventral axis formation_Homo sapiens_hsa043200.45743012
105Arginine and proline metabolism_Homo sapiens_hsa003300.44803056
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44634829
107Chronic myeloid leukemia_Homo sapiens_hsa052200.44121262
108Alcoholism_Homo sapiens_hsa050340.43396332
109Biosynthesis of amino acids_Homo sapiens_hsa012300.43231994
110NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42641726
111Toxoplasmosis_Homo sapiens_hsa051450.41893231
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.41296441
113Butanoate metabolism_Homo sapiens_hsa006500.40327844
114Toll-like receptor signaling pathway_Homo sapiens_hsa046200.39470360
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39244652
116Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39127294
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39068663
118Long-term potentiation_Homo sapiens_hsa047200.38357719
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37416421
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35473929
121Prostate cancer_Homo sapiens_hsa052150.35439837
122Ras signaling pathway_Homo sapiens_hsa040140.35338155
123Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34655057
124Carbon metabolism_Homo sapiens_hsa012000.34576478
125Oxytocin signaling pathway_Homo sapiens_hsa049210.33978183
126Platelet activation_Homo sapiens_hsa046110.33642990
127MicroRNAs in cancer_Homo sapiens_hsa052060.32511282
128Lysine degradation_Homo sapiens_hsa003100.32503722
129Calcium signaling pathway_Homo sapiens_hsa040200.32041777
130Insulin signaling pathway_Homo sapiens_hsa049100.31283692
131Vascular smooth muscle contraction_Homo sapiens_hsa042700.30843131
132Hippo signaling pathway_Homo sapiens_hsa043900.30800094
133Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30474548
134Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.29369928
135Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.28980250
136Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28750119
137Fatty acid biosynthesis_Homo sapiens_hsa000610.27321106
138Huntingtons disease_Homo sapiens_hsa050160.26812241
139Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26549143
140Pancreatic cancer_Homo sapiens_hsa052120.26363422
141Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25964612
142Colorectal cancer_Homo sapiens_hsa052100.25422443
143Galactose metabolism_Homo sapiens_hsa000520.23699221
144Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22874569
145Metabolic pathways_Homo sapiens_hsa011000.21884505
146Hepatitis C_Homo sapiens_hsa051600.21077572
147Oocyte meiosis_Homo sapiens_hsa041140.20320550
148Notch signaling pathway_Homo sapiens_hsa043300.20023939

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