MTOR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)6.65559146
2pore complex assembly (GO:0046931)5.68981125
3mitotic chromosome condensation (GO:0007076)5.23866166
4DNA unwinding involved in DNA replication (GO:0006268)4.98283959
5mitotic sister chromatid cohesion (GO:0007064)4.77835476
6lysine metabolic process (GO:0006553)4.60325144
7lysine catabolic process (GO:0006554)4.60325144
8regulation of RNA export from nucleus (GO:0046831)4.53459024
9carnitine transport (GO:0015879)4.24951661
10amino-acid betaine transport (GO:0015838)4.24951661
11dicarboxylic acid biosynthetic process (GO:0043650)4.17149713
12histone H3-K36 demethylation (GO:0070544)4.14926499
13regulation of nucleobase-containing compound transport (GO:0032239)4.10520516
14carnitine transmembrane transport (GO:1902603)3.97298022
15carnitine shuttle (GO:0006853)3.95424999
16piRNA metabolic process (GO:0034587)3.82971396
17DNA synthesis involved in DNA repair (GO:0000731)3.81535361
18aspartate family amino acid catabolic process (GO:0009068)3.76651065
19quaternary ammonium group transport (GO:0015697)3.72437323
20regulation of translational fidelity (GO:0006450)3.71615832
21alpha-linolenic acid metabolic process (GO:0036109)3.68798491
22sister chromatid segregation (GO:0000819)3.65657542
23cell-substrate adherens junction assembly (GO:0007045)3.65558057
24focal adhesion assembly (GO:0048041)3.65558057
25sodium ion export (GO:0071436)3.65177768
26fatty acid transmembrane transport (GO:1902001)3.65143128
27negative regulation of histone methylation (GO:0031061)3.61208789
28adherens junction assembly (GO:0034333)3.61186050
29mitotic sister chromatid segregation (GO:0000070)3.60822647
30DNA replication initiation (GO:0006270)3.60227466
31DNA duplex unwinding (GO:0032508)3.57627248
32chromosome condensation (GO:0030261)3.56616214
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.51894788
34synaptonemal complex assembly (GO:0007130)3.49033916
352-oxoglutarate metabolic process (GO:0006103)3.48613912
36spliceosomal tri-snRNP complex assembly (GO:0000244)3.45989935
37heterochromatin organization (GO:0070828)3.45034136
38acetyl-CoA metabolic process (GO:0006084)3.43935838
39negative regulation of DNA repair (GO:0045738)3.43656188
40cellular protein complex localization (GO:0034629)3.40978563
41protein complex localization (GO:0031503)3.37831416
42protein export from nucleus (GO:0006611)3.37760509
43mitotic nuclear envelope disassembly (GO:0007077)3.37645431
44DNA geometric change (GO:0032392)3.34894045
45membrane disassembly (GO:0030397)3.32065447
46nuclear envelope disassembly (GO:0051081)3.32065447
47paraxial mesoderm development (GO:0048339)3.32052823
48organic cation transport (GO:0015695)3.32048238
49synaptonemal complex organization (GO:0070193)3.31725736
50macroautophagy (GO:0016236)3.29296675
51DNA packaging (GO:0006323)3.26121066
52positive regulation of fatty acid beta-oxidation (GO:0032000)3.25977766
53locomotory exploration behavior (GO:0035641)3.25378732
54cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.25044436
55histone H3-K9 demethylation (GO:0033169)3.23051342
56kynurenine metabolic process (GO:0070189)3.21847550
57glucocorticoid receptor signaling pathway (GO:0042921)3.19610195
58DNA conformation change (GO:0071103)3.18048263
59protein localization to chromosome, centromeric region (GO:0071459)3.14582707
60sperm motility (GO:0030317)3.12800093
61protein-DNA complex disassembly (GO:0032986)3.11926405
62nucleosome disassembly (GO:0006337)3.11926405
63cell-substrate junction assembly (GO:0007044)3.10125660
64tricarboxylic acid cycle (GO:0006099)3.09736612
65drug transmembrane transport (GO:0006855)3.07174532
66regulation of histone H3-K9 methylation (GO:0051570)3.06735210
67COPI coating of Golgi vesicle (GO:0048205)3.06340230
68Golgi transport vesicle coating (GO:0048200)3.06340230
69histone lysine demethylation (GO:0070076)3.02545423
70corticosteroid receptor signaling pathway (GO:0031958)3.02492405
71RNA stabilization (GO:0043489)3.01215121
72mRNA stabilization (GO:0048255)3.01215121
73cell communication by electrical coupling (GO:0010644)2.99147008
74CDP-diacylglycerol biosynthetic process (GO:0016024)2.98995255
75male meiosis (GO:0007140)2.98330298
76cysteine metabolic process (GO:0006534)2.97852423
77DNA topological change (GO:0006265)2.95350450
78peptidyl-lysine dimethylation (GO:0018027)2.94359645
79* regulation of fatty acid beta-oxidation (GO:0031998)2.94299285
80amino-acid betaine metabolic process (GO:0006577)2.93790132
81tricarboxylic acid metabolic process (GO:0072350)2.92142120
82glutamate metabolic process (GO:0006536)2.90652278
83regulation of cholesterol homeostasis (GO:2000188)2.90376084
84glyoxylate metabolic process (GO:0046487)2.89717321
85histone demethylation (GO:0016577)2.88945233
86fatty acid homeostasis (GO:0055089)2.88238128
87short-chain fatty acid metabolic process (GO:0046459)2.86324396
88phosphate ion transport (GO:0006817)2.86180672
89nuclear envelope organization (GO:0006998)2.85065931
90response to epidermal growth factor (GO:0070849)2.84438314
91regulation of sister chromatid cohesion (GO:0007063)2.83218248
92homocysteine metabolic process (GO:0050667)2.82674131
93phospholipid homeostasis (GO:0055091)2.81909531
94positive regulation of cell cycle checkpoint (GO:1901978)2.81073521
95regulation of DNA damage checkpoint (GO:2000001)2.80815209
96regulation of histone H3-K27 methylation (GO:0061085)2.79498156
97DNA strand elongation involved in DNA replication (GO:0006271)2.78271402
98cellular potassium ion homeostasis (GO:0030007)2.77524788
99regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.77172264
100cellular response to epidermal growth factor stimulus (GO:0071364)2.76022051
101cellular modified amino acid catabolic process (GO:0042219)2.75890288
102sister chromatid cohesion (GO:0007062)2.75813284
103negative regulation of organelle assembly (GO:1902116)2.74948592
104serine family amino acid catabolic process (GO:0009071)2.74582392
105positive regulation of chromosome segregation (GO:0051984)2.74421985
106phosphate ion transmembrane transport (GO:0035435)2.74131588
107layer formation in cerebral cortex (GO:0021819)2.73914743
108cilium or flagellum-dependent cell motility (GO:0001539)2.73751787
109CDP-diacylglycerol metabolic process (GO:0046341)2.71918783
110chromatin assembly (GO:0031497)2.70893622
111urea metabolic process (GO:0019627)2.70671349
112urea cycle (GO:0000050)2.70671349
113positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.69728637
114regulation of mitotic spindle organization (GO:0060236)2.69328573
115DNA strand elongation (GO:0022616)2.69010542
116urate metabolic process (GO:0046415)2.67692455
117protein localization to kinetochore (GO:0034501)2.67309575
118NLS-bearing protein import into nucleus (GO:0006607)2.67015114
119positive regulation of fatty acid oxidation (GO:0046321)2.66350036
120fatty acid beta-oxidation (GO:0006635)2.65714048
121proline biosynthetic process (GO:0006561)2.64915185
122negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.64101114
123carnitine metabolic process (GO:0009437)2.63938023
124regulation of short-term neuronal synaptic plasticity (GO:0048172)2.62316516
125regulation of ARF protein signal transduction (GO:0032012)2.62238707
126cytoplasmic mRNA processing body assembly (GO:0033962)2.61907646
127synaptic vesicle maturation (GO:0016188)2.61231100
128establishment of nucleus localization (GO:0040023)2.60774040
129erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.60772410
130L-phenylalanine catabolic process (GO:0006559)2.60772410
131positive regulation of histone deacetylation (GO:0031065)2.60557814
132aromatic amino acid family catabolic process (GO:0009074)2.60021528
133pre-miRNA processing (GO:0031054)2.59703806
134positive regulation of gene expression, epigenetic (GO:0045815)2.59235842
135* regulation of fatty acid oxidation (GO:0046320)2.58594600
136COPII vesicle coating (GO:0048208)2.57726574
137cellular ketone body metabolic process (GO:0046950)2.56420941
138negative regulation of potassium ion transmembrane transport (GO:1901380)2.56371640
139gene silencing by RNA (GO:0031047)2.56332480
140nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.56168605
141protein demethylation (GO:0006482)2.56156314
142protein dealkylation (GO:0008214)2.56156314
143positive regulation of glycolytic process (GO:0045821)2.56056059
144activation of Rac GTPase activity (GO:0032863)2.55950731
145indole-containing compound catabolic process (GO:0042436)2.55930303
146indolalkylamine catabolic process (GO:0046218)2.55930303
147tryptophan catabolic process (GO:0006569)2.55930303
148nuclear pore complex assembly (GO:0051292)2.55829170
149acrosome assembly (GO:0001675)2.54668720
150negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.53142322
151dosage compensation (GO:0007549)2.52890982
152retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.51499992
153oxaloacetate metabolic process (GO:0006107)2.50166347
154embryonic process involved in female pregnancy (GO:0060136)2.49487676
155regulation of protein polyubiquitination (GO:1902914)2.49254614
156succinate metabolic process (GO:0006105)2.48810606
157cytoskeletal anchoring at plasma membrane (GO:0007016)2.48468957
158regulation of histone methylation (GO:0031060)2.47712791
159erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.47660253
160L-phenylalanine metabolic process (GO:0006558)2.47660253
161valine metabolic process (GO:0006573)2.47100902
162drug catabolic process (GO:0042737)2.46706946
163regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.45821602
164intracellular lipid transport (GO:0032365)2.45800670
165positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.45244566
166regulation of mammary gland epithelial cell proliferation (GO:0033599)2.45143241
167* peptidyl-threonine modification (GO:0018210)2.44778766
168mRNA transport (GO:0051028)2.44640203
169fructose metabolic process (GO:0006000)2.44296235
170acrosome reaction (GO:0007340)2.44219967
171NADH metabolic process (GO:0006734)2.44056576
172stress granule assembly (GO:0034063)2.43926479
173cellular sodium ion homeostasis (GO:0006883)2.43418216
174* peptidyl-threonine phosphorylation (GO:0018107)2.42714073
175fusion of sperm to egg plasma membrane (GO:0007342)2.42622637
176nucleus organization (GO:0006997)2.41953723
177regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.40639427
178regulation of early endosome to late endosome transport (GO:2000641)2.39806321
179planar cell polarity pathway involved in neural tube closure (GO:0090179)2.39226910
180negative regulation of histone modification (GO:0031057)2.38790318
181retrograde transport, vesicle recycling within Golgi (GO:0000301)2.37016776
182establishment of protein localization to Golgi (GO:0072600)2.36510366
183positive regulation of lipid catabolic process (GO:0050996)2.36435607
184meiotic chromosome segregation (GO:0045132)2.36211727
185* positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.35116469
186regulation of spindle organization (GO:0090224)2.34457731
187hippo signaling (GO:0035329)2.34405250
188biotin metabolic process (GO:0006768)2.34135974
189regulation of histone H3-K4 methylation (GO:0051569)2.33473296
190neural tube development (GO:0021915)2.32780375
191establishment of spindle localization (GO:0051293)2.32257507
192positive regulation of SMAD protein import into nucleus (GO:0060391)2.31929478
193hemidesmosome assembly (GO:0031581)2.30313448
194vesicle coating (GO:0006901)2.28588051

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.23504456
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.72694348
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.79606252
4EZH2_22144423_ChIP-Seq_EOC_Human3.77063297
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.46322725
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.72124503
7AR_21909140_ChIP-Seq_LNCAP_Human2.69853797
8EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.68963697
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.67005990
10* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.55761105
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.53643256
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.53331639
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.49329166
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.48487951
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.48381642
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.28371836
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.18757936
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.18393481
19ZNF263_19887448_ChIP-Seq_K562_Human2.13586211
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.11501817
21DROSHA_22980978_ChIP-Seq_HELA_Human2.01085913
22RARB_27405468_Chip-Seq_BRAIN_Mouse2.00350811
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.99239412
24E2F1_21310950_ChIP-Seq_MCF-7_Human1.97840537
25STAT6_21828071_ChIP-Seq_BEAS2B_Human1.95374803
26MYC_18555785_ChIP-Seq_MESCs_Mouse1.93316810
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.91797545
28PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.85171216
29* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.84192114
30ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.82881159
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.82539630
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.79313226
33ZFX_18555785_ChIP-Seq_MESCs_Mouse1.78010634
34FOXA2_19822575_ChIP-Seq_HepG2_Human1.77742351
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.75250319
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.74159163
37KDM2B_26808549_Chip-Seq_DND41_Human1.73532645
38CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.70635366
39EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.68774976
40MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67544772
41ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.64538102
42SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.62776809
43KDM2B_26808549_Chip-Seq_K562_Human1.61979981
44DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.59232070
45ZFP281_18757296_ChIP-ChIP_E14_Mouse1.58150297
46TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57131088
47KLF4_18555785_ChIP-Seq_MESCs_Mouse1.55811802
48DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.55722251
49* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.55488392
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.55392934
51* ELK3_25401928_ChIP-Seq_HUVEC_Human1.55056195
52MYC_19079543_ChIP-ChIP_MESCs_Mouse1.52251455
53FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.50677349
54KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.50620966
55VDR_21846776_ChIP-Seq_THP-1_Human1.50350191
56CHD1_26751641_Chip-Seq_LNCaP_Human1.48680948
57TCF7_22412390_ChIP-Seq_EML_Mouse1.44192426
58MYC_22102868_ChIP-Seq_BL_Human1.44162279
59* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.44155911
60NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.42577937
61RACK7_27058665_Chip-Seq_MCF-7_Human1.41731210
62ZFP281_27345836_Chip-Seq_ESCs_Mouse1.39884725
63TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.39489062
64SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.38301403
65PKCTHETA_26484144_Chip-Seq_BREAST_Human1.38045800
66REST_21632747_ChIP-Seq_MESCs_Mouse1.37317205
67TBX20_22080862_ChIP-Seq_HEART_Mouse1.37304812
68TBX20_22328084_ChIP-Seq_HEART_Mouse1.37304812
69YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33723240
70TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32653309
71CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.30129120
72KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.28405079
73CLOCK_20551151_ChIP-Seq_293T_Human1.28250934
74MYC_19030024_ChIP-ChIP_MESCs_Mouse1.27887337
75* LXR_22292898_ChIP-Seq_THP-1_Human1.25902200
76FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.25493183
77TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.25170886
78NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24447923
79* KDM2B_26808549_Chip-Seq_JURKAT_Human1.24078004
80RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.22737462
81TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.20938864
82TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.20584013
83SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.19936940
84* CREB1_26743006_Chip-Seq_LNCaP_Human1.17492880
85WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16281348
86POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.14535819
87REST_18959480_ChIP-ChIP_MESCs_Mouse1.14422936
88RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.13269295
89* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.12632976
90* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11605922
91SMC4_20622854_ChIP-Seq_HELA_Human1.11524518
92WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11362569
93ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.11348219
94NCOR1_26117541_ChIP-Seq_K562_Human1.09971598
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09182936
96STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08757261
97NANOG_21062744_ChIP-ChIP_HESCs_Human1.08189886
98SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.08151078
99CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08022184
100WDR5_24793694_ChIP-Seq_LNCAP_Human1.07612641
101AR_19668381_ChIP-Seq_PC3_Human1.07074371
102RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06374729
103SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06373343
104KLF4_19829295_ChIP-Seq_ESCs_Human1.05934924
105ESR2_21235772_ChIP-Seq_MCF-7_Human1.05916853
106WT1_19549856_ChIP-ChIP_CCG9911_Human1.05340710
107ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05336275
108* KDM5A_27292631_Chip-Seq_BREAST_Human1.05163767
109CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05098947
110FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.04841144
111HNF4A_19822575_ChIP-Seq_HepG2_Human1.04616062
112SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04576283
113ATF3_27146783_Chip-Seq_COLON_Human1.04218504
114NANOG_18555785_ChIP-Seq_MESCs_Mouse1.03572564
115* UBF1/2_26484160_Chip-Seq_HMECs_Human1.03115422
116TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03044960
117ELK4_26923725_Chip-Seq_MESODERM_Mouse1.02927739
118GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.02912165
119OCT4_19829295_ChIP-Seq_ESCs_Human1.02130149
120ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01715715
121FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01402191
122RUNX1_27514584_Chip-Seq_MCF-7_Human1.01074871
123TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00793177
124MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00263274
125ZNF274_21170338_ChIP-Seq_K562_Hela0.98787462
126NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.97746704
127UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.96805517
128* XRN2_22483619_ChIP-Seq_HELA_Human0.96716480
129SOX2_21211035_ChIP-Seq_LN229_Gbm0.96658412
130KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96217215
131HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96067951
132SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95346618
133EP300_21415370_ChIP-Seq_HL-1_Mouse0.94897963
134CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94509070
135THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94178535
136ISL1_27105846_Chip-Seq_CPCs_Mouse0.92512762
137NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.91021388
138CTCF_27219007_Chip-Seq_Bcells_Human0.90780960
139STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.89973962
140HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.89878350
141TFEB_21752829_ChIP-Seq_HELA_Human0.89748028
142MTF2_20144788_ChIP-Seq_MESCs_Mouse0.88647799
143TET1_21490601_ChIP-Seq_MESCs_Mouse0.88584280
144MYC_18358816_ChIP-ChIP_MESCs_Mouse0.88267065
145AHR_22903824_ChIP-Seq_MCF-7_Human0.87981641
146CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87804686
147P68_20966046_ChIP-Seq_HELA_Human0.87731632
148SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.86025635
149* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.85033517
150DNAJC2_21179169_ChIP-ChIP_NT2_Human0.85003895
151NFIB_24661679_ChIP-Seq_LUNG_Mouse0.84037059
152FOXO3_23340844_ChIP-Seq_DLD1_Human0.84024370
153CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.83622710
154MITF_21258399_ChIP-Seq_MELANOMA_Human0.83076566
155TP63_22573176_ChIP-Seq_HFKS_Human0.82702254
156TBX3_20139965_ChIP-Seq_ESCs_Mouse0.81798296
157ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.81607660
158ARNT_22903824_ChIP-Seq_MCF-7_Human0.81102162
159PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.80742393
160GATA1_26923725_Chip-Seq_HPCs_Mouse0.80668448
161* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.80418104
162SMAD4_21741376_ChIP-Seq_HESCs_Human0.80157470
163BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80002314
164TBX3_20139965_ChIP-Seq_MESCs_Mouse0.79631481

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.28117259
2MP0002139_abnormal_hepatobiliary_system3.90279046
3MP0005410_abnormal_fertilization3.63759932
4MP0008057_abnormal_DNA_replication3.40597507
5MP0003111_abnormal_nucleus_morphology2.98913891
6MP0004859_abnormal_synaptic_plasticity2.92899344
7MP0005365_abnormal_bile_salt2.72738651
8MP0008961_abnormal_basal_metabolism2.71541347
9MP0010094_abnormal_chromosome_stability2.66573089
10MP0008877_abnormal_DNA_methylation2.58619592
11MP0000569_abnormal_digit_pigmentation2.56685812
12MP0005409_darkened_coat_color2.50012480
13MP0003705_abnormal_hypodermis_morpholog2.48075370
14MP0005670_abnormal_white_adipose2.46125522
15MP0003693_abnormal_embryo_hatching2.41629921
16MP0005451_abnormal_body_composition2.40792064
17MP0005085_abnormal_gallbladder_physiolo2.36535555
18* MP0001730_embryonic_growth_arrest2.33151889
19MP0003077_abnormal_cell_cycle2.29693149
20MP0003566_abnormal_cell_adhesion2.28277423
21MP0004130_abnormal_muscle_cell2.27071947
22MP0003252_abnormal_bile_duct2.23117231
23MP0002877_abnormal_melanocyte_morpholog2.20042060
24MP0002837_dystrophic_cardiac_calcinosis2.19313395
25* MP0004957_abnormal_blastocyst_morpholog2.15460468
26MP0000537_abnormal_urethra_morphology2.01313961
27MP0000751_myopathy1.98370634
28MP0010329_abnormal_lipoprotein_level1.97506738
29MP0002009_preneoplasia1.96400513
30MP0005666_abnormal_adipose_tissue1.93798444
31MP0004043_abnormal_pH_regulation1.91364605
32MP0003941_abnormal_skin_development1.89506058
33* MP0001672_abnormal_embryogenesis/_devel1.87713768
34* MP0005380_embryogenesis_phenotype1.87713768
35MP0009780_abnormal_chondrocyte_physiolo1.85081076
36* MP0003984_embryonic_growth_retardation1.80457641
37MP0005332_abnormal_amino_acid1.80177395
38MP0000350_abnormal_cell_proliferation1.80053864
39MP0001915_intracranial_hemorrhage1.79738120
40MP0001849_ear_inflammation1.78351785
41MP0004084_abnormal_cardiac_muscle1.71201632
42* MP0002088_abnormal_embryonic_growth/wei1.70992539
43MP0003698_abnormal_male_reproductive1.68333744
44MP0004272_abnormal_basement_membrane1.63921703
45MP0003329_amyloid_beta_deposits1.59992739
46* MP0002086_abnormal_extraembryonic_tissu1.59677738
47MP0008875_abnormal_xenobiotic_pharmacok1.58494464
48* MP0002084_abnormal_developmental_patter1.58341480
49MP0003635_abnormal_synaptic_transmissio1.57420125
50MP0002269_muscular_atrophy1.53981281
51MP0008007_abnormal_cellular_replicative1.53854243
52* MP0002080_prenatal_lethality1.53612892
53MP0005076_abnormal_cell_differentiation1.51153305
54MP0002653_abnormal_ependyma_morphology1.47609747
55* MP0002085_abnormal_embryonic_tissue1.47458205
56* MP0008932_abnormal_embryonic_tissue1.46011703
57MP0001929_abnormal_gametogenesis1.44581945
58MP0000733_abnormal_muscle_development1.42387322
59MP0000428_abnormal_craniofacial_morphol1.42347826
60MP0009046_muscle_twitch1.41593383
61* MP0001697_abnormal_embryo_size1.41185500
62MP0005623_abnormal_meninges_morphology1.40099411
63MP0003890_abnormal_embryonic-extraembry1.39598042
64MP0005375_adipose_tissue_phenotype1.39448216
65MP0004270_analgesia1.38485368
66MP0004808_abnormal_hematopoietic_stem1.36935290
67* MP0004087_abnormal_muscle_fiber1.35227471
68MP0010234_abnormal_vibrissa_follicle1.33580689
69MP0002118_abnormal_lipid_homeostasis1.31306746
70MP0004885_abnormal_endolymph1.30107212
71MP0003091_abnormal_cell_migration1.29817026
72MP0004197_abnormal_fetal_growth/weight/1.29720675
73MP0002909_abnormal_adrenal_gland1.28895617
74MP0004215_abnormal_myocardial_fiber1.28129790
75MP0003453_abnormal_keratinocyte_physiol1.27736830
76MP0002063_abnormal_learning/memory/cond1.26752449
77MP0004185_abnormal_adipocyte_glucose1.25956670
78MP0003283_abnormal_digestive_organ1.25228212
79MP0005621_abnormal_cell_physiology1.24557669
80MP0002697_abnormal_eye_size1.20947750
81MP0004858_abnormal_nervous_system1.20217191
82MP0009672_abnormal_birth_weight1.20213560
83MP0002396_abnormal_hematopoietic_system1.18115348
84MP0000747_muscle_weakness1.17962801
85MP0004264_abnormal_extraembryonic_tissu1.17448992
86MP0010630_abnormal_cardiac_muscle1.16046190
87MP0002971_abnormal_brown_adipose1.15301089
88MP0003385_abnormal_body_wall1.15181094
89MP0004019_abnormal_vitamin_homeostasis1.14988561
90* MP0004233_abnormal_muscle_weight1.14689498
91MP0005187_abnormal_penis_morphology1.14598853
92MP0005535_abnormal_body_temperature1.11857344
93MP0008058_abnormal_DNA_repair1.11235568
94MP0000609_abnormal_liver_physiology1.10378908
95MP0001765_abnormal_ion_homeostasis1.07932389
96MP0002796_impaired_skin_barrier1.07372335
97MP0003300_gastrointestinal_ulcer1.07293368
98MP0000604_amyloidosis1.07154064
99MP0000003_abnormal_adipose_tissue1.05963416
100MP0008260_abnormal_autophagy1.04045325
101MP0002161_abnormal_fertility/fecundity1.03025302
102MP0005330_cardiomyopathy1.02608572
103MP0009745_abnormal_behavioral_response1.02564932
104MP0000579_abnormal_nail_morphology1.02540078
105MP0005584_abnormal_enzyme/coenzyme_acti1.02446800
106MP0009840_abnormal_foam_cell1.01934630
107* MP0001661_extended_life_span1.00094300
108MP0008438_abnormal_cutaneous_collagen0.99712128
109MP0002138_abnormal_hepatobiliary_system0.98637457
110MP0003935_abnormal_craniofacial_develop0.98575803
111MP0002925_abnormal_cardiovascular_devel0.97681731
112MP0010368_abnormal_lymphatic_system0.97199107
113* MP0004036_abnormal_muscle_relaxation0.96771770
114MP0003191_abnormal_cellular_cholesterol0.96648961
115MP0002060_abnormal_skin_morphology0.96587250
116MP0002064_seizures0.96218719
117MP0000432_abnormal_head_morphology0.94210462
118MP0004811_abnormal_neuron_physiology0.93345184
119MP0000678_abnormal_parathyroid_gland0.93016248
120MP0002822_catalepsy0.92756471
121MP0003045_fibrosis0.92702693
122MP0003937_abnormal_limbs/digits/tail_de0.92690895
123MP0000313_abnormal_cell_death0.92448398
124* MP0005384_cellular_phenotype0.92282321
125MP0001299_abnormal_eye_distance/0.92011867
126MP0003868_abnormal_feces_composition0.89043706
127* MP0000759_abnormal_skeletal_muscle0.88061479
128MP0002092_abnormal_eye_morphology0.87752675
129* MP0002078_abnormal_glucose_homeostasis0.87731024
130MP0001440_abnormal_grooming_behavior0.87597154
131MP0003195_calcinosis0.87240622
132MP0009643_abnormal_urine_homeostasis0.87021613
133MP0009697_abnormal_copulation0.86776050
134MP0003123_paternal_imprinting0.86612650
135MP0010678_abnormal_skin_adnexa0.86125436
136MP0010030_abnormal_orbit_morphology0.84997013
137MP0005319_abnormal_enzyme/_coenzyme0.84778358
138* MP0003861_abnormal_nervous_system0.83604672
139MP0003633_abnormal_nervous_system0.83299273
140MP0002249_abnormal_larynx_morphology0.83287758
141MP0006138_congestive_heart_failure0.83276327
142MP0010352_gastrointestinal_tract_polyps0.82506583
143MP0005501_abnormal_skin_physiology0.81625242
144MP0002210_abnormal_sex_determination0.81226119
145MP0003690_abnormal_glial_cell0.81078870
146MP0002572_abnormal_emotion/affect_behav0.79788723
147MP0008569_lethality_at_weaning0.79542136
148MP0001145_abnormal_male_reproductive0.79431079
149MP0000377_abnormal_hair_follicle0.79054192
150MP0000266_abnormal_heart_morphology0.77947788
151MP0003942_abnormal_urinary_system0.77484973
152MP0009053_abnormal_anal_canal0.77159739
153MP0001756_abnormal_urination0.76899265
154MP0005257_abnormal_intraocular_pressure0.76714398
155MP0003787_abnormal_imprinting0.75268518
156MP0008775_abnormal_heart_ventricle0.74603932
157MP0005647_abnormal_sex_gland0.73721736
158MP0003221_abnormal_cardiomyocyte_apopto0.73672876
159MP0008874_decreased_physiological_sensi0.73620533
160MP0001666_abnormal_nutrient_absorption0.73178989
161MP0003631_nervous_system_phenotype0.72410688
162MP0009703_decreased_birth_body0.72087435
163MP0010307_abnormal_tumor_latency0.71372165
164MP0000013_abnormal_adipose_tissue0.71258061
165MP0003115_abnormal_respiratory_system0.71083744
166MP0003943_abnormal_hepatobiliary_system0.70846197
167MP0005448_abnormal_energy_balance0.70329694
168MP0005023_abnormal_wound_healing0.70210597
169* MP0005620_abnormal_muscle_contractility0.70096247
170MP0002168_other_aberrant_phenotype0.69709382
171MP0002089_abnormal_postnatal_growth/wei0.69402757
172MP0003879_abnormal_hair_cell0.69221640
173MP0000762_abnormal_tongue_morphology0.68806782
174MP0001346_abnormal_lacrimal_gland0.68654182
175MP0004085_abnormal_heartbeat0.68573162
176MP0005334_abnormal_fat_pad0.68531607
177MP0002970_abnormal_white_adipose0.68333090
178MP0003315_abnormal_perineum_morphology0.67683461

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the lower motor neuron (HP:0002366)4.28996525
2Dysmetric saccades (HP:0000641)3.97067080
3Ketosis (HP:0001946)2.96789856
4Gout (HP:0001997)2.91158954
5Hand muscle atrophy (HP:0009130)2.88081496
6Distal upper limb amyotrophy (HP:0007149)2.75527437
7Upper limb amyotrophy (HP:0009129)2.75527437
8Ketoacidosis (HP:0001993)2.75349223
9Difficulty running (HP:0009046)2.74294718
10Ankyloglossia (HP:0010296)2.73899629
11Chromosomal breakage induced by crosslinking agents (HP:0003221)2.73608606
12Hyperglycinuria (HP:0003108)2.67450474
13Vertebral arch anomaly (HP:0008438)2.65050203
14Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.61562208
15Chromsome breakage (HP:0040012)2.60008541
16Postural instability (HP:0002172)2.57509446
17Deep venous thrombosis (HP:0002625)2.57434415
18Hyporeflexia of lower limbs (HP:0002600)2.55630203
19Long eyelashes (HP:0000527)2.50486921
20Increased nuchal translucency (HP:0010880)2.49805909
21Myoglobinuria (HP:0002913)2.46463187
22Lymphangioma (HP:0100764)2.43939702
23Abnormality of serine family amino acid metabolism (HP:0010894)2.43697416
24Abnormality of glycine metabolism (HP:0010895)2.43697416
25Resting tremor (HP:0002322)2.42564270
26Exercise-induced myalgia (HP:0003738)2.42405185
27Urinary urgency (HP:0000012)2.42013924
28Urinary bladder sphincter dysfunction (HP:0002839)2.40916309
29Myokymia (HP:0002411)2.34697873
30Ulnar bowing (HP:0003031)2.31697025
31Bundle branch block (HP:0011710)2.30744912
32Heterotopia (HP:0002282)2.30313467
33Abnormality of oral frenula (HP:0000190)2.29756060
34Abnormality of the distal phalanx of the thumb (HP:0009617)2.29302133
35Hyperammonemia (HP:0001987)2.29197059
36Abnormality of glutamine family amino acid metabolism (HP:0010902)2.26779624
37Impaired vibration sensation in the lower limbs (HP:0002166)2.25970675
38Hyperacusis (HP:0010780)2.21900108
39Global brain atrophy (HP:0002283)2.19191225
40Elfin facies (HP:0004428)2.17587908
41Absent/shortened dynein arms (HP:0200106)2.15613553
42Dynein arm defect of respiratory motile cilia (HP:0012255)2.15613553
43Flat acetabular roof (HP:0003180)2.15479226
44Deviation of the thumb (HP:0009603)2.15036483
45Increased purine levels (HP:0004368)2.14884013
46Hyperuricemia (HP:0002149)2.14884013
47Disproportionate tall stature (HP:0001519)2.13998161
48Relative macrocephaly (HP:0004482)2.11872188
49Macroorchidism (HP:0000053)2.11779203
50Insidious onset (HP:0003587)2.10323345
51Termporal pattern (HP:0011008)2.10323345
52Abnormal social behavior (HP:0012433)2.10169288
53Impaired social interactions (HP:0000735)2.10169288
54Astrocytoma (HP:0009592)2.08307181
55Abnormality of the astrocytes (HP:0100707)2.08307181
56Broad face (HP:0000283)2.07236708
57Sudden death (HP:0001699)2.06633513
58Abnormality of the calcaneus (HP:0008364)2.06048814
59Hamartoma of the eye (HP:0010568)2.05797926
60Sandal gap (HP:0001852)2.05240598
61Deep philtrum (HP:0002002)2.03575234
62Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.03448567
63Pseudobulbar signs (HP:0002200)2.02922236
64Shallow orbits (HP:0000586)2.02652226
65Neonatal hypoglycemia (HP:0001998)2.02633580
66High anterior hairline (HP:0009890)2.01412821
67Asymmetry of the thorax (HP:0001555)2.00555696
68Renovascular hypertension (HP:0100817)2.00366963
69Abnormal urine output (HP:0012590)2.00189618
70Hyperglycinemia (HP:0002154)1.99151337
71Bowel incontinence (HP:0002607)1.97514937
72Neoplasm of the heart (HP:0100544)1.96848220
73Increased connective tissue (HP:0009025)1.95788714
74Action tremor (HP:0002345)1.95773851
75Proximal placement of thumb (HP:0009623)1.95023742
76Xanthomatosis (HP:0000991)1.94232504
77EMG: neuropathic changes (HP:0003445)1.94178780
78Distal lower limb amyotrophy (HP:0008944)1.93981056
79Septate vagina (HP:0001153)1.93802979
80Infertility (HP:0000789)1.93720475
81Advanced eruption of teeth (HP:0006288)1.92920367
82Abnormality of purine metabolism (HP:0004352)1.92816221
83Spastic tetraparesis (HP:0001285)1.92359040
84Dislocated radial head (HP:0003083)1.91970715
85Hypoalphalipoproteinemia (HP:0003233)1.90230341
86Cerebral aneurysm (HP:0004944)1.89054132
87Abnormality of ocular smooth pursuit (HP:0000617)1.89031690
88Intrahepatic cholestasis (HP:0001406)1.88902302
89Centrally nucleated skeletal muscle fibers (HP:0003687)1.88848406
90Mitral valve prolapse (HP:0001634)1.88476056
91Abnormal drinking behavior (HP:0030082)1.87797298
92Polydipsia (HP:0001959)1.87797298
93Selective tooth agenesis (HP:0001592)1.87649014
94Increased circulating renin level (HP:0000848)1.86776799
95Metaphyseal cupping (HP:0003021)1.86268817
96Cortical dysplasia (HP:0002539)1.85570464
97Exercise-induced muscle cramps (HP:0003710)1.84387725
98Back pain (HP:0003418)1.84221906
99Hypoglycemic coma (HP:0001325)1.84194228
100Amyotrophic lateral sclerosis (HP:0007354)1.84148193
101Deep palmar crease (HP:0006191)1.84109218
102Abnormality of the salivary glands (HP:0010286)1.83993915
103Polyuria (HP:0000103)1.82956168
104Abnormal large intestine physiology (HP:0012700)1.82783191
105Cerebral inclusion bodies (HP:0100314)1.82528968
106Persistence of primary teeth (HP:0006335)1.82351296
107Abnormality of sulfur amino acid metabolism (HP:0004339)1.81405112
108Abnormality of the fingertips (HP:0001211)1.81157236
109Dysdiadochokinesis (HP:0002075)1.80501630
110Focal seizures (HP:0007359)1.80000029
111Status epilepticus (HP:0002133)1.79809622
112Urethral obstruction (HP:0000796)1.79743516
113Abnormality of renal excretion (HP:0011036)1.78938321
114Truncal obesity (HP:0001956)1.78485067
115Lower limb amyotrophy (HP:0007210)1.78422944
116Ependymoma (HP:0002888)1.78291352
117Skull defect (HP:0001362)1.78251357
118Short nail (HP:0001799)1.77222612
119Uterine leiomyosarcoma (HP:0002891)1.77058479
120Leiomyosarcoma (HP:0100243)1.77058479
121Spastic diplegia (HP:0001264)1.76622224
122Insomnia (HP:0100785)1.76176867
123Sparse lateral eyebrow (HP:0005338)1.76176530
124Chronic bronchitis (HP:0004469)1.75446026
125Obsessive-compulsive behavior (HP:0000722)1.75282732
126Protrusio acetabuli (HP:0003179)1.75277811
127Impaired vibratory sensation (HP:0002495)1.74841372
128Hypopigmentation of the fundus (HP:0007894)1.74678605
129Hypokalemic alkalosis (HP:0001949)1.74422533
130Impaired smooth pursuit (HP:0007772)1.74389772
131Upper motor neuron abnormality (HP:0002127)1.73927385
132Missing ribs (HP:0000921)1.73559067
133Long palpebral fissure (HP:0000637)1.73510150
134Overlapping toe (HP:0001845)1.73194505
135Abnormality of chromosome segregation (HP:0002916)1.72486647
136Genetic anticipation (HP:0003743)1.72355106
137Fibroma (HP:0010614)1.71015902
138Anal stenosis (HP:0002025)1.70825840
139Tetraplegia (HP:0002445)1.70168753
140Malignant gastrointestinal tract tumors (HP:0006749)1.70124273
141Gastrointestinal carcinoma (HP:0002672)1.70124273
142Abnormality of the radial head (HP:0003995)1.70061157
143Hemiplegia (HP:0002301)1.69869422
144Difficulty climbing stairs (HP:0003551)1.69552524
145Narrow palate (HP:0000189)1.69031196
146Patellar dislocation (HP:0002999)1.68270745
147Papillary thyroid carcinoma (HP:0002895)1.68063993
148Verrucae (HP:0200043)1.65930116
149Papilloma (HP:0012740)1.65930116
150Premature rupture of membranes (HP:0001788)1.65456980
151Rhinitis (HP:0012384)1.65035581
152Abnormality of fatty-acid metabolism (HP:0004359)1.63994581
153Epidermoid cyst (HP:0200040)1.63368359
154Progressive external ophthalmoplegia (HP:0000590)1.62955269
155Fibrous tissue neoplasm (HP:0012316)1.62817940
156Mitral stenosis (HP:0001718)1.62634386
157Cafe-au-lait spot (HP:0000957)1.62454935
158Male infertility (HP:0003251)1.62330244
159Pointed chin (HP:0000307)1.61835717
160Poor eye contact (HP:0000817)1.60923995
161Germ cell neoplasia (HP:0100728)1.60160367
162Broad distal phalanx of finger (HP:0009836)1.59533866
163Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.59289290
164Cubitus valgus (HP:0002967)1.58876328
165Capillary hemangiomas (HP:0005306)1.57272036
166Hammertoe (HP:0001765)1.56603523
167Osteolytic defects of the phalanges of the hand (HP:0009771)1.56556986
168Osteolytic defects of the hand bones (HP:0009699)1.56556986
169Spinal rigidity (HP:0003306)1.55190438
170Natal tooth (HP:0000695)1.54895418
171Acute myeloid leukemia (HP:0004808)1.54605551
172Broad thumb (HP:0011304)1.54230737
173Attention deficit hyperactivity disorder (HP:0007018)1.53586760
174Arnold-Chiari malformation (HP:0002308)1.53488340
175Precocious puberty (HP:0000826)1.53221371
176Nephroblastoma (Wilms tumor) (HP:0002667)1.52750770
177Syringomyelia (HP:0003396)1.52633104
178Spinal cord lesions (HP:0100561)1.52633104
179Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.52338986
180Ectopic kidney (HP:0000086)1.51622522
181Limited elbow extension (HP:0001377)1.51592869
18211 pairs of ribs (HP:0000878)1.51304874

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK33.82070461
2PDK43.82070461
3PRKD33.18702938
4ICK3.12242930
5SMG13.00470681
6TRIB32.82616103
7CDK122.65026810
8PKN22.55898042
9MAP3K102.52010938
10CAMK1G2.44253893
11EEF2K2.43432027
12CAMK1D2.13225450
13PRPF4B1.98141213
14MAP3K41.95005344
15PDK21.94428377
16TTK1.91860335
17WNK41.80271759
18MET1.78441650
19SIK11.76646108
20MAP3K91.74670960
21STK381.69599556
22WNK31.60478442
23PNCK1.56286111
24RIPK11.55194426
25NEK11.53546899
26NTRK31.38042152
27TYRO31.37885812
28TESK11.31695831
29CAMKK11.29648249
30NTRK21.29333695
31PAK61.27995207
32WNK11.26624508
33DAPK21.25606139
34MST1R1.25240111
35SIK21.24440707
36LMTK21.24342413
37TSSK61.22953155
38IRAK31.20617461
39SCYL21.17121949
40CHEK11.11117191
41* MTOR1.08829558
42FGFR21.08189055
43SGK31.08174458
44PTK21.07993650
45KSR21.07913763
46TTN1.04282862
47MAP3K71.03960188
48NEK21.00601473
49MINK10.99460637
50MAP2K40.99157996
51CDK70.98378868
52PTK60.96583928
53PDK10.96415037
54PDGFRA0.96197787
55RPS6KB20.96148395
56PTK2B0.95728743
57PHKG20.95279626
58PHKG10.95279626
59MAP3K80.92483358
60RET0.92109442
61MELK0.92103515
62BCKDK0.91370326
63ERN10.91009397
64KSR10.87477557
65TAF10.87289321
66STK110.87252910
67CHEK20.86130156
68ALK0.82498050
69ATR0.82056102
70BRAF0.81450927
71MARK10.81045704
72PDGFRB0.80691854
73EPHA40.78642461
74* PRKAA10.75892659
75RAF10.75037525
76TAOK10.74732001
77AKT30.74701519
78PDPK10.74246507
79PBK0.73626448
80BRSK10.72707074
81SRPK10.72126868
82NEK90.71937838
83MAP3K130.71891355
84SGK20.71588833
85LATS20.71319021
86FGFR40.70521134
87LATS10.70108374
88CDK20.64955887
89PRKCH0.64207297
90CDK10.64081030
91PAK40.63945627
92NTRK10.63093647
93ATM0.62862906
94DMPK0.62338525
95SGK2230.62180156
96SGK4940.62180156
97CDK90.61549256
98BRD40.57066980
99DYRK1B0.55824000
100BMX0.53148813
101PAK30.53072675
102PAK20.52650930
103FGFR10.52456960
104BRSK20.51902607
105CDK40.51552270
106SGK10.50817637
107STK30.50708603
108CDK50.50394218
109CAMK40.50246611
110CDC42BPA0.50088603
111CLK10.49718135
112MAP3K20.49562590
113CDK60.48885016
114MARK20.48507078
115AURKB0.48300528
116MAPK110.47982862
117PRKAA20.47300291
118* RPS6KA30.47271639
119AKT20.47163131
120FGFR30.46594774
121PASK0.44472033
122PINK10.43595369
123BUB10.42526084
124PRKCZ0.42085393
125CDC70.42021841
126CSNK1D0.41864733
127STK40.41345346
128PLK10.41014789
129MAP3K60.40973003
130MAP2K30.40961892
131GSK3B0.39904041
132STK390.39441638
133DAPK10.39250412
134PRKDC0.38993535
135NEK60.38680562
136MAPK140.38113529
137CDK80.38073732
138MAPK100.37386838
139YES10.37197922
140IRAK20.36818313
141OXSR10.36225830
142WEE10.36209538
143MAPK120.36169927
144PRKCG0.35351449
145GRK60.35109474
146INSRR0.35090097
147RPS6KA20.34856716
148CAMK10.33299681
149JAK10.32843580

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.47115923
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.33469475
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.65555426
4Propanoate metabolism_Homo sapiens_hsa006402.54519199
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.49242733
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.48943283
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.20471262
8Fatty acid degradation_Homo sapiens_hsa000712.19341657
9Chronic myeloid leukemia_Homo sapiens_hsa052202.18719532
10Pyruvate metabolism_Homo sapiens_hsa006202.06870867
11Cell cycle_Homo sapiens_hsa041101.99868239
12Fatty acid metabolism_Homo sapiens_hsa012121.99781458
13Arginine biosynthesis_Homo sapiens_hsa002201.99035042
14DNA replication_Homo sapiens_hsa030301.97809426
15Butanoate metabolism_Homo sapiens_hsa006501.89286215
16Adherens junction_Homo sapiens_hsa045201.85514851
17Thyroid cancer_Homo sapiens_hsa052161.84416595
18PPAR signaling pathway_Homo sapiens_hsa033201.81786141
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.80500431
20Lysine degradation_Homo sapiens_hsa003101.78086750
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.76490028
22Bile secretion_Homo sapiens_hsa049761.74348882
23Fatty acid biosynthesis_Homo sapiens_hsa000611.70215444
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.68153633
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.65844112
26Non-homologous end-joining_Homo sapiens_hsa034501.62512023
27Carbon metabolism_Homo sapiens_hsa012001.62280392
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.58687575
29mRNA surveillance pathway_Homo sapiens_hsa030151.56122070
30Tryptophan metabolism_Homo sapiens_hsa003801.53567144
31Glucagon signaling pathway_Homo sapiens_hsa049221.46358578
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.45839515
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.43994720
34Pancreatic cancer_Homo sapiens_hsa052121.42966422
35* MicroRNAs in cancer_Homo sapiens_hsa052061.42795384
36Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.42134983
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.39180587
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.34619717
39* Prostate cancer_Homo sapiens_hsa052151.33830422
40* ErbB signaling pathway_Homo sapiens_hsa040121.32895764
41Small cell lung cancer_Homo sapiens_hsa052221.31647421
42Dorso-ventral axis formation_Homo sapiens_hsa043201.26450080
43Biosynthesis of amino acids_Homo sapiens_hsa012301.26114091
44Colorectal cancer_Homo sapiens_hsa052101.24741669
45Renal cell carcinoma_Homo sapiens_hsa052111.24594163
46RNA transport_Homo sapiens_hsa030131.22126486
47Notch signaling pathway_Homo sapiens_hsa043301.18341738
48Focal adhesion_Homo sapiens_hsa045101.16345480
49Bladder cancer_Homo sapiens_hsa052191.16342555
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.15983019
51Glycerolipid metabolism_Homo sapiens_hsa005611.15471307
52* Acute myeloid leukemia_Homo sapiens_hsa052211.15215624
53Carbohydrate digestion and absorption_Homo sapiens_hsa049731.12963334
54Mismatch repair_Homo sapiens_hsa034301.11224371
55Selenocompound metabolism_Homo sapiens_hsa004501.05964932
56* Proteoglycans in cancer_Homo sapiens_hsa052051.03778502
57Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.03136905
58Long-term potentiation_Homo sapiens_hsa047201.02675420
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00820310
60Viral carcinogenesis_Homo sapiens_hsa052031.00479760
61* Type II diabetes mellitus_Homo sapiens_hsa049300.99893937
62Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.99130096
63Gastric acid secretion_Homo sapiens_hsa049710.96447131
64* Insulin resistance_Homo sapiens_hsa049310.95816719
65Prion diseases_Homo sapiens_hsa050200.94688244
66* AMPK signaling pathway_Homo sapiens_hsa041520.92227855
67* mTOR signaling pathway_Homo sapiens_hsa041500.91608436
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90911500
69Synaptic vesicle cycle_Homo sapiens_hsa047210.90897086
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89222338
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88829445
72* Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87249257
73Aldosterone synthesis and secretion_Homo sapiens_hsa049250.85720092
74* Choline metabolism in cancer_Homo sapiens_hsa052310.85268777
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84941524
76* Central carbon metabolism in cancer_Homo sapiens_hsa052300.84442971
77beta-Alanine metabolism_Homo sapiens_hsa004100.84062680
78Renin secretion_Homo sapiens_hsa049240.83518182
79ECM-receptor interaction_Homo sapiens_hsa045120.82981219
80* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81410375
81Insulin secretion_Homo sapiens_hsa049110.81151920
82Olfactory transduction_Homo sapiens_hsa047400.80999899
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.80654035
84* Adipocytokine signaling pathway_Homo sapiens_hsa049200.78651391
85Salivary secretion_Homo sapiens_hsa049700.77923371
86* Insulin signaling pathway_Homo sapiens_hsa049100.77856885
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77825315
88Amphetamine addiction_Homo sapiens_hsa050310.77733243
89Peroxisome_Homo sapiens_hsa041460.77637148
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77389624
91Circadian entrainment_Homo sapiens_hsa047130.76670066
92One carbon pool by folate_Homo sapiens_hsa006700.76319549
93Estrogen signaling pathway_Homo sapiens_hsa049150.76158049
94Prolactin signaling pathway_Homo sapiens_hsa049170.74899092
95Vitamin B6 metabolism_Homo sapiens_hsa007500.73872343
96Spliceosome_Homo sapiens_hsa030400.73624708
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73355602
98Base excision repair_Homo sapiens_hsa034100.73244599
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73125846
100Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.72110000
101Thyroid hormone synthesis_Homo sapiens_hsa049180.71782123
102Hippo signaling pathway_Homo sapiens_hsa043900.70744114
103FoxO signaling pathway_Homo sapiens_hsa040680.70539331
104Tight junction_Homo sapiens_hsa045300.70332999
105cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69486639
106Melanoma_Homo sapiens_hsa052180.68623760
107N-Glycan biosynthesis_Homo sapiens_hsa005100.68579291
108GABAergic synapse_Homo sapiens_hsa047270.68379565
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67850067
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66744558
111Nucleotide excision repair_Homo sapiens_hsa034200.66673595
112* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66006451
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65235570
114Fat digestion and absorption_Homo sapiens_hsa049750.64775710
115* Glioma_Homo sapiens_hsa052140.62977636
116Glutamatergic synapse_Homo sapiens_hsa047240.62921709
117TGF-beta signaling pathway_Homo sapiens_hsa043500.62755166
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62345323
119ABC transporters_Homo sapiens_hsa020100.61857824
120Hepatitis B_Homo sapiens_hsa051610.61205957
121Dopaminergic synapse_Homo sapiens_hsa047280.60640050
122Oxytocin signaling pathway_Homo sapiens_hsa049210.60169985
123Alcoholism_Homo sapiens_hsa050340.58158141
124Dilated cardiomyopathy_Homo sapiens_hsa054140.57270654
125* Pathways in cancer_Homo sapiens_hsa052000.56259057
126Amoebiasis_Homo sapiens_hsa051460.55699477
127Morphine addiction_Homo sapiens_hsa050320.54688045
128Inositol phosphate metabolism_Homo sapiens_hsa005620.54494726
129HTLV-I infection_Homo sapiens_hsa051660.54129560
130Phenylalanine metabolism_Homo sapiens_hsa003600.53184603
131B cell receptor signaling pathway_Homo sapiens_hsa046620.53020689
132Wnt signaling pathway_Homo sapiens_hsa043100.52943576
133Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52107934
134Melanogenesis_Homo sapiens_hsa049160.51232718
135Apoptosis_Homo sapiens_hsa042100.50840617
136cAMP signaling pathway_Homo sapiens_hsa040240.50723087
137Starch and sucrose metabolism_Homo sapiens_hsa005000.50604918
138Oocyte meiosis_Homo sapiens_hsa041140.50066567
139Non-small cell lung cancer_Homo sapiens_hsa052230.49947085
140Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48862518
141Cholinergic synapse_Homo sapiens_hsa047250.48641455
142Endometrial cancer_Homo sapiens_hsa052130.47612031
143Nicotine addiction_Homo sapiens_hsa050330.45344787
144Complement and coagulation cascades_Homo sapiens_hsa046100.44642269
145Cardiac muscle contraction_Homo sapiens_hsa042600.42751955
146Glycerophospholipid metabolism_Homo sapiens_hsa005640.41667929
147Fructose and mannose metabolism_Homo sapiens_hsa000510.40969490
148Pentose phosphate pathway_Homo sapiens_hsa000300.39691868
149Calcium signaling pathway_Homo sapiens_hsa040200.38597965
150Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.36839013
151VEGF signaling pathway_Homo sapiens_hsa043700.36381063
152GnRH signaling pathway_Homo sapiens_hsa049120.35833888
153Neurotrophin signaling pathway_Homo sapiens_hsa047220.34103021
154Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34022180
155Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33767742
156Gap junction_Homo sapiens_hsa045400.32492900
157* Phospholipase D signaling pathway_Homo sapiens_hsa040720.31927146
158Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30900768
159Cocaine addiction_Homo sapiens_hsa050300.29722350

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